Polyoxy Alcohol Moiety Patents (Class 560/63)
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Patent number: 4227009Abstract: Phenoxyphenoxy-propionic acid derivatives of the formula ##STR1## exhibit an outstanding herbicidal activity against a wide variety of weed grasses and are well tolerated by dicotyledonous crop plants and various cereals.Type: GrantFiled: May 24, 1977Date of Patent: October 7, 1980Assignee: Hoechst AktiengesellschaftInventors: Manfred Koch, Reinhard Handte, Gerhard Horlein, Heinrich Leditschke, Helmut Kocher, Peter Langeluddeke
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Patent number: 4225533Abstract: Novel esters of ether and thioether substituted cyclopropanecarboxylic acids, synthesis thereof, and intermediates therefor, such esters being useful as pesticides.Type: GrantFiled: June 1, 1979Date of Patent: September 30, 1980Assignee: Zoecon CorporationInventor: Clive A. Henrick
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Patent number: 4182761Abstract: Acyloxy-substituted aryloxyalkyl diketones, useful as anti-viral agents, are prepared either by esterification of the corresponding hydroxy-substituted compounds or by reacting a haloalkyl diketone with an alkali metal salt of an acyloxy-substituted phenol.Type: GrantFiled: June 7, 1978Date of Patent: January 8, 1980Assignee: Sterling Drug Inc.Inventors: Joseph C. Collins, Guy D. Diana
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Patent number: 4175947Abstract: Phenoxy-phenoxypropionic acid derivatives of the formula ##STR1## wherein R is hydrogen or halogen, and R.sub.1 is substituted alkyl, cyclohexenyl, phenylalkenyl or (substituted) alkinyl, are interesting selective herbicides having a special activity against weed grasses. They are obtained for example by reaction of corresponding phenoxypropionic acid halides with hydroxy compounds of the formula HO--R.sub.1.Type: GrantFiled: April 21, 1977Date of Patent: November 27, 1979Assignee: Hoechst AktiengesellschaftInventors: Manfred Koch, Reinhard Handte, Gerhard Horlein, Hermann Bieringer, Peter Langeluddeke
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Patent number: 4169720Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, chlorine or fluorine; andR.sub.3 is --CH.sub.2 OH, --CH.sub.2 --O--COR.sub.4, --CH.sub.2 --O--CONHR.sub.5, --COOH, --COOCat, --COOR.sub.6, --CONR.sub.7 R.sub.8 or --CO--SR.sub.9 ;where Cat is one equivalent of an inorganic or organic cation;R.sub.4 is hydrogen or alkyl of 1 to 10 carbon atoms;R.sub.5 is alkyl of 1 to 4 carbon atoms, phenyl or halo-substituted phenyl;R.sub.6 is alkyl of 1 to 10 carbon atoms which may optionally have a chloro, hydroxyl, lower alkoxy, lower alkoxy-lower alkoxy, lower alkylthio, amino, mono-lower alkyl-amino, di-lower alkyl-amino, allyloxy or phenoxy substituent attached thereto; phenyl; benzyl; monochloro-benzyl; dichloro-benzyl; cyclohexyl; 1-ethynyl-cyclohexyl; lower alkenyl; lower alkynyl; --N.dbd.C(CH.sub.3).sub.2 ; 2--(2',4',5'-trichloro-phenoxy)-ethyl, 2-(2', 5'-dichloro-4'-bromo-phenoxy)-ethyl; or ##STR2## R.sub.Type: GrantFiled: July 28, 1977Date of Patent: October 2, 1979Assignee: Celamerck GmbH & Co. KGInventors: Erich Schacht, Gunter Lauterbach, Werner Mehrhof, Jurgen Curtze, Gerbert Linden, Siegmund Lust, Klaus Thomas
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Patent number: 4168385Abstract: This invention discloses .alpha.-aryloxy or .alpha.-arylthio para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.Type: GrantFiled: February 17, 1977Date of Patent: September 18, 1979Assignee: American Cyanamid CompanyInventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
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Patent number: 4168386Abstract: The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-13,14-didehydro-16-phenyl-17,18,19,20- tetranor-PGF.sub.1 compounds. These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.Type: GrantFiled: July 12, 1978Date of Patent: September 18, 1979Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4166912Abstract: The present invention relates to novel 9-deoxy-9-methylene-inter-phenylene-16-phenyl-PGF compounds.These compounds are useful pharmacological agents, and are useful for the same purposes as the corresponding PGE-type compounds.Type: GrantFiled: July 12, 1978Date of Patent: September 4, 1979Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4156011Abstract: The sulphur- and oxygen-containing diaryl compounds of the formula: ##STR1## in which A and B, which may be the same or different, represent O, S, SO or SO.sub.2,Alk is a C.sub.1 -C.sub.4 hydrocarbon radical with a straight or branched chain, R represents COOH, an esterified COOH group, a carboxylic amide group, OH, O-SO.sub.2 CH.sub.3, NH.sub.2, NHR.sub.1, NR.sub.1 R.sub.2, NHZOH, NHZNR.sub.1 R.sub.2, C(.dbd.NH)NH.sub.2, C(.dbd.NH)NHOH or 2-.DELTA..sup.2 -imidazolinyl, Z is a C.sub.2 -C.sub.4 hydrocarbon radical with a straight or branched chain, and R.sub.1 and R.sub.2 each represent a C.sub.1 -C.sub.Type: GrantFiled: April 5, 1977Date of Patent: May 22, 1979Assignee: Societe Anonyme dite: Laboratoire L. LafonInventors: Victor Lafon, Louis Lafon
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Patent number: 4153803Abstract: Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: ##STR1## wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms;A.sup.1 and A.sup.2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A.sup.1 and A.sup.Type: GrantFiled: March 1, 1977Date of Patent: May 8, 1979Assignee: Siegfried AktiengesellschaftInventors: Kurt Thiele, Quazi Ahmed, Rudolf Adrian, Ulrich Jahn
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Patent number: 4118583Abstract: Therapeutically active compounds of the general formula: ##STR1## wherein Ac.sub.1 is a first acyl group, Ac.sub.2 is a second acyl group different from Ac.sub.1, A is a C--C bond or a divalent organic residue; R.sub.1, R.sub.2 are a hydrogen atom or a lower alkyl group, R.sub.1 and R.sub.2 together being able to take part in the formation of a ring having up to 6 atoms, A, R.sub.1 and R.sub.2 may be substituted by -OH groups esterified or not by acyl groups.Type: GrantFiled: December 6, 1976Date of Patent: October 3, 1978Assignee: Laboratories om Societe AnonymeInventors: Pierre Baudet, Jean-Paul Ricard, Adrian Schulthess
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Patent number: 4113966Abstract: This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: August 1, 1977Date of Patent: September 12, 1978Assignee: The Upjohn CompanyInventor: Herman W. Smith
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Patent number: 4113965Abstract: This invention comprises certain analogs of the prostaglandins in which the double bond between C-13 and C-14 is replaced by a triple bond. Also provided in this invention, are novel chemical processes and novel chemical intermediates useful in the preparation of the above prostaglandin analogs. These prostaglandin analogs exhibit prostaglandin-like activity, and are accordingly useful for the same pharmacological purposes as the prostaglandins. Among these purposes are blood pressure lowering, labor induction at term, reproductive-cycle regulation, gastric antisecretory action, and the like.Type: GrantFiled: August 1, 1977Date of Patent: September 12, 1978Assignee: The Upjohn CompanyInventor: Herman W. Smith
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Patent number: 4073876Abstract: In the preparation of glycol esters by the oxidation of an olefin in the presence of a catalyst comprising tellurium, wherein the accumulation of foreign metals in association with the tellurium catalyst component has an adverse effect upon the reaction, such foreign metals are maintained at low levels while the tellurium catalyst values are recovered for recycling in high yield by purging a portion of a high-boiling residual fraction produced in the distillation treatment of the reaction mixture and treating the purged portion with water and/or an aqueous alkaline solution.Type: GrantFiled: July 1, 1976Date of Patent: February 14, 1978Assignee: Halcon International, Inc.Inventor: Vijai P. Gupta
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Patent number: 4072754Abstract: Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.Type: GrantFiled: November 25, 1974Date of Patent: February 7, 1978Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
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Patent number: 4065432Abstract: Thermally stable, rigid bisphenols of the formula ##STR1## WHERE R is ##STR2## or ##STR3## where R.sup.2 is arylene or substituted arylene, andR.sup.1 is hydrogen or acyl,Are used to prepare thermally stable, rigid, ordered polyesters of the formula ##STR4## where R.sup.4 is arylene or substituted arylene, andn is at least about 10.Type: GrantFiled: December 16, 1976Date of Patent: December 27, 1977Assignee: E. I. Du Pont de Nemours and CompanyInventor: August Henry Frazer
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Patent number: 4055595Abstract: Derivatives of 2-hydroxy-3,3,3-trifluoro-2-(alkyl or trifluoromethyl)propionic acid bearing a phenyl or naphthyl group linked to the 2-hydroxy group either directly or via an intermediate methylene group. The compounds reduce the concentrations of cholesterol, total esterified fatty acids or fibrinogen in the blood plasma of test animals and some compounds show anti-arthritic properties.Type: GrantFiled: November 10, 1975Date of Patent: October 25, 1977Assignee: Imperial Chemical Industries LimitedInventors: David Bryan Haydock, Thomas Patrick Cunningham Mulholland, Jeffrey Meyrick Thorp