Polycyclo Ring System Patents (Class 562/466)
  • Patent number: 4193931
    Abstract: Novel 7-(substituted indanyl or naphthyl)-3-methyl-octa-2,4,6-triene derivatives useful as anti-tumor agents are disclosed.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: March 18, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Peter Loeliger
  • Patent number: 4175209
    Abstract: A process, and intermediates for the preparation of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid are described. The acid possesses antiinflammatory and analgesic activity.
    Type: Grant
    Filed: September 5, 1978
    Date of Patent: November 20, 1979
    Assignee: American Hoechst Corporation
    Inventors: Arthur R. McFadden, Richard C. Allen, Thomas B. K. Lee
  • Patent number: 4174306
    Abstract: Detergent compositions containing self-requestering surfactants the molecules of which contain both a hydrophilic structure and a lipophilic structure are disclosed. The compositions comprise at least 5% by weight, of hydrosoluble salts having the formula ##STR1## in which R is alkyl, arylalkyl or alkylaryl of from 6 to 18 carbon atoms;at least one of the groups represented by Z is a --CH.sub.2 --COO.sup.- Me.sup.+ carboxymethylene group in which Me.sup.+ represents an ion selected from sodium, potassium and ammonium ions and from quaternary onium cations, and combinations thereof, and the remaining Z groups, which may be the same or different, represent H or a carboxymethylene as defined above.
    Type: Grant
    Filed: February 27, 1978
    Date of Patent: November 13, 1979
    Assignee: Montedison S.p.A.
    Inventors: Salvatore Gafa, Fulvio Burzio
  • Patent number: 4168385
    Abstract: This invention discloses .alpha.-aryloxy or .alpha.-arylthio para substituted phenyl acetic acid compounds that are useful in lowering sterol and triglyceride serum levels.
    Type: Grant
    Filed: February 17, 1977
    Date of Patent: September 18, 1979
    Assignee: American Cyanamid Company
    Inventors: Ronald I. Trust, Francis J. McEvoy, Jay D. Albright
  • Patent number: 4152527
    Abstract: The 15-substituted-.omega.-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue specificity of action.
    Type: Grant
    Filed: December 27, 1973
    Date of Patent: May 1, 1979
    Assignee: Pfizer Inc.
    Inventors: Hans-Jurgen E. Hess, Thomas K. Schaaf
  • Patent number: 4144397
    Abstract: Valuable 2-aryl-propionic acids are prepared by the direct coupling of aryl magnesium bromides with a mixed magnesium halide complex of alpha-bromopropionic acid.
    Type: Grant
    Filed: December 19, 1977
    Date of Patent: March 13, 1979
    Assignee: Syntex Corporation
    Inventors: Gary J. Matthews, Robert A. Arnold
  • Patent number: 4142054
    Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. A continuous process using a Scheibel column is disclosed. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 - to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as an anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: February 27, 1979
    Assignee: The Upjohn Company
    Inventors: Sanjay I. Amin, Jerry A. Walker
  • Patent number: 4135051
    Abstract: 2-Aryl-C.sub.3 to C.sub.6 -alkanoate esters are prepared economically by reacting an enol ether of an aryl alkyl ketone with a trivalent thallium salt in an organic solvent. The trivalent thallium ions can be regenerated by adding a peracid and a reactive form of manganese, ruthenium, cobalt, iridium, hafnium, osmium or neobium to oxidize monovalent thallium ions to the trivalent state, in a sequential, continuous or stoichiometric procedure. The ester intermediate product is then converted to the corresponding 2-aryl-C.sub.3 - to C.sub.6 -alkanoic acid or salt thereof. The aryl group is selected so the resulting acid product will be a useful compound such as anti-inflammatory, analgesic and anti-pyretic drug or agriculturally useful product. Examples of drug acids which can be made by this process include ibuprofen, flurbiprofen, fenoprofen and naproxen and the like.
    Type: Grant
    Filed: June 16, 1977
    Date of Patent: January 16, 1979
    Assignee: The Upjohn Company
    Inventor: Jerry A. Walker
  • Patent number: 4131748
    Abstract: p-Terphenylene-dicarboxylic acids in which aromatic groups are attached to the middle phenyl group of the terphenylene moiety. The compounds are useful as monomers in the preparation of rod-like, para-ordered aromatic heterocyclic polymers.
    Type: Grant
    Filed: June 29, 1977
    Date of Patent: December 26, 1978
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Fred E. Arnold, James F. Wolfe
  • Patent number: 4125731
    Abstract: Novel indan compounds of the formula ##STR1## wherein A and X are each ethylene or vinylene; B is C.sub.2-4 alkylene; R and R.sub.2 are each hydrogen or C.sub.1-4 alkyl; R.sub.1 is C.sub.1-8 alkyl; <C = Z is <C = O, or ##STR2## and its non-toxic salts, which are useful as antiulcers, gastric secretion inhibitors, and hypotensors.
    Type: Grant
    Filed: December 8, 1976
    Date of Patent: November 14, 1978
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Akihiko Sugie, Hiromi Shimomura, Junki Katsube, Hisao Yamamoto
  • Patent number: 4123457
    Abstract: Invention relates to improved processes for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-indenyl-3-acetic acid, to intermediates thereof, and to the preparation of said intermediates.
    Type: Grant
    Filed: September 22, 1976
    Date of Patent: October 31, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Roger J. Tull, David G. Melillo
  • Patent number: 4118420
    Abstract: Organic compounds having a substituent represented by the formula ##STR1## wherein M is alkali metal or ammonium are useful complexing agents for metal and/or alkaline earth metal ions.
    Type: Grant
    Filed: March 25, 1976
    Date of Patent: October 3, 1978
    Assignee: Monsanto Company
    Inventor: Kent P. Lannert