Polycyclo Ring System Patents (Class 562/466)
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Publication number: 20130261122Abstract: The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.Type: ApplicationFiled: December 16, 2011Publication date: October 3, 2013Applicant: N30 Pharmaceuticls, Inc.Inventors: Xicheng Sun, Jian Qiu, Adam Stout
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Patent number: 8546392Abstract: The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.Type: GrantFiled: March 27, 2008Date of Patent: October 1, 2013Assignee: Universitaet des SaarlandesInventors: Rolf Hartmann, Martin Frotscher, Sandrine Oberwinkler, Erika Ziegler, Josef Messinger, Heinrich-Hubert Thole
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Patent number: 8524939Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: GrantFiled: August 24, 2011Date of Patent: September 3, 2013Assignee: Chirogate International Inc.Inventors: Shih-Yi Wei, Min-Kuan Hsu, Ming-Kun Hsu
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Publication number: 20130217768Abstract: Processes for preparing water soluble and oil soluble antioxidant compositions extracted together from Labiatae herbs in a single extraction using an alcohol and water solvent, followed by a simple, yet effective purification step that allows the separation of the water soluble antioxidative fractions containing mainly rosmarinic acid from antioxidative fractions containing mainly carnosic acid and carnosol, without cumbersome acid/base partitioning steps.Type: ApplicationFiled: October 25, 2011Publication date: August 22, 2013Applicant: KALAMAZOO HOLDINGS, INC.Inventors: Roger Nahas, Elizabeth Barren, Gregory S. Reynhout
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Patent number: 8513456Abstract: A carnosic acid-rich plant extract can be produced by extracting a dried and comminuted plant material containing carnosic acid with supercritical CO2 at a pressure of at least 200 bar and at a temperature of at most 100° C. In a first step, supercritical CO2 in a quantity of 10 to 50 kg of CO2 per kg of plant material is passed through the plant material to obtain a first CO2 extract. In a second step, additional supercritical CO2 is passed through the plant material to obtain a second CO2 extract, and a carnosic acid-rich plant extract is separated from the second CO2 extract by lowering the pressure.Type: GrantFiled: October 12, 2010Date of Patent: August 20, 2013Assignee: Evonik Degussa GmbHInventors: Johann Wiesmueller, Franz Michlbauer, Ralf Kahleyss, Helmut Hausner
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Publication number: 20130203727Abstract: The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).Type: ApplicationFiled: July 1, 2011Publication date: August 8, 2013Applicant: GILEAD SCIENCES, INC.Inventors: Kerim Babaoglu, Elizabeth Bacon, Kyla Bjornson, Hongyan Guo, Randall L. Halcomb, Paul Hrvatin, John O. Link, Hongtao Liu, Ryan McFadden, Michael L. Mitchell, Paul Roethle, James Taylor, James D. Trenkle, Randall W. Vivian, Lianhong Xu
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Patent number: 8497393Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.Type: GrantFiled: July 13, 2012Date of Patent: July 30, 2013Assignee: United Therapeutics CorporationInventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
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Patent number: 8481782Abstract: The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.Type: GrantFiled: June 2, 2011Date of Patent: July 9, 2013Assignee: United Therapeutics CorporationInventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
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Patent number: 8399507Abstract: Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.Type: GrantFiled: October 27, 2008Date of Patent: March 19, 2013Assignee: Merck Sharp & Dohme Corp.Inventors: Gui-Bai Liang, Xibin Liao, Weiguo Liu, Paul E. Finke, Dooseop Kim, Lihu Yang, Songnian Lin
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Publication number: 20130053581Abstract: Novel processes for preparing optically active cyclopentanones 1 which are useful for the preparation of benzindene Prostaglandins and novel cyclopentanones are provided. The invention also provides novel processes of preparing benzindene Prostaglandins and novel intermediates for benzindene Prostaglandins.Type: ApplicationFiled: August 24, 2011Publication date: February 28, 2013Inventors: Shih-Yi WEI, Min-Kuan Hsu, Ming-Kun Hsu
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Patent number: 8383852Abstract: Compounds comprising cyclic moiety and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: February 19, 2008Date of Patent: February 26, 2013Assignee: Emisphere Technologies, Inc.Inventors: Pingwah Tang, Steven Dinh
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Patent number: 8350079Abstract: There is provided a stable monohydrate form of treprostinil and pharmaceutical formulation comprising the same, method of making and using the same.Type: GrantFiled: May 7, 2009Date of Patent: January 8, 2013Assignee: United Therapeutics CorporationInventor: David A. Walsh
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Publication number: 20120283470Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.Type: ApplicationFiled: July 13, 2012Publication date: November 8, 2012Inventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
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Patent number: 8299296Abstract: The spiro compound represented by the following general formula [Ia], its pharmaceutically acceptable salt or a solvate thereofType: GrantFiled: October 24, 2008Date of Patent: October 30, 2012Assignee: Japan Tobacco Inc.Inventors: Takashi Shimada, Hiroshi Ueno, Kazuhiro Tsutsumi, Kouichi Aoyagi, Tomoyuki Manabe, Shin-Ya Sasaki, Susumu Katoh
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Publication number: 20120245366Abstract: The present invention relates to arylated camphenes, processes for their preparation and uses thereof for the manufacture of medicaments for the treatment of diseases, disorders or conditions associated with, or benefiting from stimulation of CB2 receptors.Type: ApplicationFiled: November 18, 2010Publication date: September 27, 2012Inventors: Raphael Mechoulam, Lital Magid, Esther Shohami, Itai Bab
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Publication number: 20120214869Abstract: Novel ligand compounds having the structural formula (I): in which: Ar is a radical selected from among the radicals of formulae (a)-(c) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, or, alternatively into cosmetic compositions.Type: ApplicationFiled: April 30, 2012Publication date: August 23, 2012Applicant: GALDERMA RESEARCH & DEVELOPMENTInventors: Thibaud BIADATTI, Jean-Marie Arlabosse
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Publication number: 20120209026Abstract: A carnosic acid-rich plant extract can be produced by extracting a dried and comminuted plant material containing carnosic acid with supercritical CO2 at a pressure of at least 200 bar and at a temperature of at most 100° C. In a first step, super-critical CO2 in a quantity of 10 to 50 kg of CO2 per kg of plant material is passed through the plant material to obtain a first CO2 extract. In a second step, additional supercritical CO2 is passed through the plant material to obtain a second CO2 extract, and a carnosic acid-rich plant extract is separated from the second CO2 extract by lowering the pressure.Type: ApplicationFiled: October 12, 2010Publication date: August 16, 2012Applicant: EVONIK DEGUSSA GMBHInventors: Johann Wiesmueller, Franz Michlbauer, Ralf Kahleyss, Helmut Hausner
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Patent number: 8242305Abstract: This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.Type: GrantFiled: December 15, 2008Date of Patent: August 14, 2012Assignee: United Therapeutics CorporationInventors: Hitesh Batra, Sudersan M. Tuladhar, Raju Penmasta, David A. Walsh
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Publication number: 20120197041Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.Type: ApplicationFiled: March 30, 2012Publication date: August 2, 2012Inventors: Hitesh BATRA, Raju PENMASTA, Vijay SHARMA, Sudersan M. TULADHAR, David A. WALSH
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Publication number: 20120190888Abstract: The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.Type: ApplicationFiled: March 30, 2012Publication date: July 26, 2012Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
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Publication number: 20120184622Abstract: The present invention provides compositions comprising a prostacyclin or prostacyclin analogue, or a pharmaceutically acceptable salt thereof for use in preventing or treating cystic fibrosis. The invention also provides the use of a kit comprising a prostacyclin or prostacyclin analogue for treating or preventing a condition associated with cystic fibrosis in a subject.Type: ApplicationFiled: August 5, 2010Publication date: July 19, 2012Applicant: SCIPHARM SaRLInventors: Michael Freissmuth, Xaver Koenig, Christina Gloeckel
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Publication number: 20120170118Abstract: Presently described are multilayer optical films, oriented polyester films, negatively birefringent copolyester polymers, fluorene monomers, and polyester polymers prepared from such fluorene monomers. In one embodiment, the multilayer optical film comprises at least one first birefringent optical layer; and at least one second optical layer having a lower birefringence than the first optical layer; wherein at least one of the optical layers comprises a negatively birefringent polyester polymer comprising a backbone and repeat units comprising at least one pendent aromatic group that is conformationally locked relative to the backbone.Type: ApplicationFiled: November 23, 2011Publication date: July 5, 2012Inventors: Lei Wang, David T. Yust, George W. Griesgraber, Stephen A. Johnson, David S. Hays
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Publication number: 20120116094Abstract: The present invention generally relates to compositions comprising and methods for forming functionalized carbon-based nanostructures.Type: ApplicationFiled: November 3, 2011Publication date: May 10, 2012Applicant: Massachusetts Institute of TechnologyInventors: Timothy M. Swager, William R. Collins, Wiktor Lewandowski, Ezequiel Schmois, Stefanie Sydlik, Joseph Walish, John B. Goods
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Publication number: 20120116112Abstract: Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: ApplicationFiled: December 30, 2011Publication date: May 10, 2012Applicants: LES LABORATOIRES SERVIER, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Jean-Louis PEGLION, Olivier Baudoin, Nicolas Audic, Manon Chaumontet, Riccardo Piccardi
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Patent number: 8168679Abstract: The present invention concerns salts of Tramadol and Naproxen and their crystalline forms, and compositions thereof, for the treatment of pain, as well as their process for preparation.Type: GrantFiled: July 31, 2008Date of Patent: May 1, 2012Assignee: Laboratorios del Dr. Esteve, S.A.Inventors: Helmut Heinrich Buschmann, Antoni Torrens-Jover, Josep Mas-Prio, Jordi Benet-Buchholz, Lluis Sola-Carandell, Jordi Carles Ceron-Bertran
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Patent number: 8148572Abstract: The invention relates to substituted phenylacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.Type: GrantFiled: October 5, 2006Date of Patent: April 3, 2012Assignee: AstraZeneca ABInventors: Timothy Jon Luker, Rukhsana Tasneem Mohammed, Stephen Thom, Anil Patel
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Publication number: 20120035196Abstract: [Problem] The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes. [Means for Solution] The present inventors have extensively studied a compound having a GPR40 agonistic activity, and as a result, they have found that the compound (I) of the present invention or a pharmaceutically acceptable salt thereof, in which a carboxylic acid is bonded to a bicyclic or tricyclic moiety through methylene, and further, a benzene ring substituted with a monocyclic 6-membered aromatic ring is bonded to a bicyclic or tricyclic moiety through —O-methylene or —NH-methylene, has an excellent GPR40 agonistic activity. They have also found that the compound has an excellent insulin secretion promoting action and strongly inhibits increase in the blood glucose after glucose loading, thereby completing the present invention.Type: ApplicationFiled: April 21, 2010Publication date: February 9, 2012Inventors: Kenji Negoro, Kei Ohnuki, Yasuhiro Yonetoku, Kazuyuki Kuramoto, Yasuharu Urano, Hideyuki Watanabe
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Publication number: 20120029226Abstract: The present invention provides a method for the synthesis of optically pure ?-aryl propionic acid derivatives comprising subjecting the corresponding racemic ?-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.Type: ApplicationFiled: February 4, 2010Publication date: February 2, 2012Inventors: Bernardus Kaptein, Elias Vlieg, Willem Lieuwe Noorduin
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Patent number: 8106235Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.Type: GrantFiled: June 16, 2008Date of Patent: January 31, 2012Assignee: Galderma Research & DevelopmentInventors: Thibaud Biadatti, Etienne Thoreau
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Patent number: 8106232Abstract: The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: December 10, 2008Date of Patent: January 31, 2012Assignee: Theravance, Inc.Inventors: Sean G. Trapp, Michael R. Leadbetter, Daniel D. Long, John R. Jacobsen, Priscilla Van Dyke, Pierre-Jean Colson, Miroslav Rapta, Ying Yu
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Patent number: 8101793Abstract: Are described compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.Type: GrantFiled: July 18, 2002Date of Patent: January 24, 2012Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Lucio Merlini, Sabrina Dallavalle, Sergio Penco, Giuseppe Giannini, Claudio Pisano, Loredana Vesci
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Patent number: 8101791Abstract: The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.Type: GrantFiled: December 10, 2008Date of Patent: January 24, 2012Assignee: Theravance, Inc.Inventors: Michael R. Leadbetter, Sean G. Trapp, Daniel D. Long, John R. Jacobsen, Sabine Axt
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Publication number: 20120016031Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.Type: ApplicationFiled: September 23, 2011Publication date: January 19, 2012Applicant: GALDERMA Research & DevelopmentInventors: Thibaud BIADATTI, Etienne Thoreau
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Publication number: 20110319641Abstract: The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.Type: ApplicationFiled: June 2, 2011Publication date: December 29, 2011Inventors: Hitesh Batra, Raju Penmasta, Vijay Sharma, Sudersan M. Tuladhar, David A. Walsh
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Publication number: 20110306498Abstract: The present invention provides a method and a composition for restoring pollen fertility by suppressing formation insufficiency in a pollen formation process due to a high-temperature or low-temperature stress. The present invention provides a fertility restorative agent comprising an auxin as an active ingredient, and a method for restoring the fertility of a plants of the family Poaceae, comprising spreading an auxin. Moreover, the present invention provides a fertility restorative agent containing as an active ingredient a substance which inhibits auxin action, and a method for restoring the fertility of rice plant, including spreading a substance which inhibits auxin action.Type: ApplicationFiled: July 8, 2011Publication date: December 15, 2011Inventors: Atsushi Higashitani, Masao Watanabe, Tadashi Sakata
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Publication number: 20110294815Abstract: This invention relates to novel prostacyclin analogs and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel prostacyclin analogs that are derivatives of treprostinil. This invention also provides compositions comprising a compound of this invention and a carrier and the use disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering analogues of prostacyclin, such as treprostinil.Type: ApplicationFiled: June 26, 2009Publication date: December 1, 2011Inventor: Scott L. Harbeson
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Publication number: 20110288066Abstract: The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.Type: ApplicationFiled: February 9, 2010Publication date: November 24, 2011Applicant: MERCK SERONO S.A.Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Christophe Cleva, Adeline Pretre
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Publication number: 20110288057Abstract: The invention relates to the use of and mainly novel compounds of the formula I wherein the moieties are as defined in the description, which are useful as farnesyl pyrophosphate synthase modulators and e.g. in the treatment of proliferative diseases.Type: ApplicationFiled: October 12, 2009Publication date: November 24, 2011Applicant: Novartis AGInventors: Simona Cotesta, Joseph Fraser Glickman, Wolfgang Jahnke, Andreas Marzinzik, Silvio Ofner, Jean-Michel Rondeau, Thomas Zoller
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Publication number: 20110281948Abstract: The invention relates to the use of calixarenes for preventing or limiting the transfer of an actinide in the body from a site of skin contamination.Type: ApplicationFiled: December 17, 2009Publication date: November 17, 2011Applicant: INSTITUT DE RADIOPROTECTION ET DE SURETE NUCLEAIREInventors: Aurélie Spagnul, François Rebiere, Guillaume Phan, Céline Bouvier-Capely, Elias Fattal
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Patent number: 8049032Abstract: A solid acid having a core of calixarene or calix resorcinarene. The solid acid is an ion conducting compound in which at least one of the hydroxyl groups is substituted by an organic group having a cation exchange group at a terminal end, a polymer electrolyte membrane including the same, and a fuel cell using the polymer electrolyte membrane. The polymer electrolyte membrane can provide low methanol crossover and high ionic conductivity. Accordingly, a fuel cell having high efficiency can be obtained by using the polymer electrolyte membrane.Type: GrantFiled: October 12, 2006Date of Patent: November 1, 2011Assignee: Samsung SDI Co., Ltd.Inventors: Jae-jun Lee, Myung-sup Jung, Do-yun Kim, Jin-gyu Lee, Sang-kook Mah
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Patent number: 8049034Abstract: Biphenyl compounds having the formula (I): are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell differentiation and/or proliferation disorder, for treating acne, for treating psoriasis.Type: GrantFiled: June 16, 2008Date of Patent: November 1, 2011Assignee: Galderma Research & DevelopmentInventors: Thibaud Biadatti, Etienne Thoreau
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Patent number: 8044099Abstract: Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules are further characterized in that they exhibit at least one modulated pharmacokinetic property upon administration to a host as compared to a free drug control. The subject bifunctional molecules find use in a variety of therapeutic applications.Type: GrantFiled: December 13, 2004Date of Patent: October 25, 2011Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Roger Briesewitz, Gerald R. Crabtree, Thomas J. Wandless
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Publication number: 20110257374Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: January 19, 2011Publication date: October 20, 2011Applicant: Sirigen, Inc.Inventors: Brent S. Gaylord, Jean M. Wheeler, Glenn P. Bartholomew, Yongchao Liang, Janice W. Hong, William H. Huisman, Frank Peter Uckert, Lan T. Tran, Adrian Charles Vernon Palmer, Trung Nguyen, Russell A. Baldocchi
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Publication number: 20110256550Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 17, 2011Publication date: October 20, 2011Applicant: Sirigen, Inc.Inventors: Brent S. Gaylord, Jean M. Wheeler, Glenn P. Bartholomew, Frank Peter Uckert, Janice W. Hong, William H. Huisman, Yongchao Liang
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Publication number: 20110256549Abstract: Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.Type: ApplicationFiled: March 17, 2011Publication date: October 20, 2011Applicant: Sirigen, Inc.Inventors: Brent S. Gaylord, Jean M. Wheeler, Glenn P. Bartholomew, Frank Peter Uckert, Janice W. Hong, William H. Huisman
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Publication number: 20110190330Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I?A or I?B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.Type: ApplicationFiled: October 13, 2009Publication date: August 4, 2011Applicant: AMGEN INC.Inventors: Sean P. Brown, Paul Dransfield, Xiaohui Du, Zice Fu, Jonathan Houze, XianYun Jiao, Sujen Lai, An-Rong Li, Jiwen Liu, Zhihua Ma, Julio C. Medina, Vatee Pattaropong, Wang Shen, Marc Vimolratana, Yingcai Wang, Zhongyu Wang, Ming Yu, Liusheng Zhu
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Publication number: 20110172460Abstract: There is described a process for the manufacture of a racemic 2-aryl propionic acid compound, or a pharmaceutically acceptable salt thereof, which comprises reacting the S- or R-enantiomer of the corresponding 2-aryl propionic acid compound with a base.Type: ApplicationFiled: June 30, 2009Publication date: July 14, 2011Applicant: AESICA PHARMACEUTICALS LIMITEDInventors: Stephen John Martin, Scott Dale Makin
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Publication number: 20110144207Abstract: The invention particularly discloses a process for preparing aryl alkyl carboxylic acid salts by preparing aqueous alkali solution, adding aryl alkyl carboxylic acid to said alkali solution at a temperature ranging from 4° to 121° C. for obtaining a clear solution, preferably by heating and/or stirring and concentrating and cooling to obtain aryl alkyl carboxylic acid salt The invention therefore discloses solid oral dosage forms and compositions of aryl alkyl carboxylic acid salts which are free of organic solvent/so. The solid oral dose compositions of aryl alkyl carboxylic acid salts of the invention are prepared in situ from aryl alkyl carboxylic acids and bases to obtain aryl acid alkyl carboxylic acid sails in crystalline/powder form with or without the use of pharmaceutical excipients.Type: ApplicationFiled: August 14, 2009Publication date: June 16, 2011Applicant: SHASUN CHEMICALS AND DRUGS LIMITEDInventors: Nandkumar Chodankar, Milind Biyani, Mohan Muthunarayanan, Selvaraju Radhakrishnan, Sathish Kumar Santhanampillai, Rajendran Paul Nadar, Vivekanandan Sundaramurthy, Sakthivel Lakshamana Prabu
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Publication number: 20110105443Abstract: The present invention relates to salts of Memantine and COX-INHIBITORs, their crystal form, the processes for preparation of the same and their uses for the treatment of various disorders, including pain.Type: ApplicationFiled: March 6, 2009Publication date: May 5, 2011Applicant: LABORATORIES DEL DR. ESTEVE, S.A.Inventors: Helmut Heinrich Buschmann, Nicolas Tesson, Joan Farran, Llorenc Rafecas
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Publication number: 20110065129Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.Type: ApplicationFiled: February 11, 2009Publication date: March 17, 2011Inventors: Derek B. Lowe, Philip L. Wickens, Xin Ma, Mingbao Zhang, William H. Bullock, Philip D. G. Coish, Ingo A. Mugge, Andreas Stolle, Ming Wang, Yamin Wang, Chengzhi Zhang, Hai-Jun Zhang, Lei Zhu, Manami Tsutsumi, James N. Livingston