Halogen Patents (Class 562/472)
  • Patent number: 8962527
    Abstract: A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: February 24, 2015
    Assignee: Nufarm Australia Limited
    Inventor: Eduard Kravets
  • Publication number: 20150051410
    Abstract: Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: wherein R2, R3 and R4 are as defined in the specification are provided. Novel intermediates for the preparations of isomer free Prostaglandins and derivatives thereof are also provided.
    Type: Application
    Filed: August 15, 2013
    Publication date: February 19, 2015
    Applicant: CHIROGATE INTERNATIONAL INC.
    Inventors: Shih-Yi Wei, Yu-Chih Yeh, Min-Kuan Hsu, Li-Ta Kao
  • Publication number: 20140336258
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 13, 2014
    Inventor: Menachem Shoham
  • Publication number: 20140173780
    Abstract: A method is disclosed for the Agrobacterium-mediated germline transformation of soybean, comprising infecting split soybean seeds, with a portion of the embryonic axis, with Agrobacterium tumefaciens containing a transgene. The method can further comprise regenerating the explants produced from the transformation of the split soybean seeds comprising a portion of embryonic axis in vitro on selection medium.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 19, 2014
    Inventors: Dayakar Pareddy, Sivarama R. Chennareddy, Tatyana Minnicks, Olga Karpova, David Griffin, Jayakumar P. Samuel, Kelley A. Smith, Rodrigo Sarria-Millan, Tejinder Kumar Mall
  • Publication number: 20140135518
    Abstract: A compound of formula (I) wherein Rf is —CF3, —C2F5, or —CF2CFXCF3; X is —F, or —OC3F7; Y is —H, —Cl, or —Br; R is —OH, —(CH2)nOH, —(OCH2CH2)mOH, —(CH2)n(OCH2CH2)mOH, —O—C(O)—R1, —(CH2)nO—C(O)R1, —(OCH2CH2)mOC(O)—R1, —C(O)NHw(CH2CH2OH)2-w, —C?N, —C?CH, or —C(O)R2; n is 1 to 10; m is 1 to 10; R1 is C1 to C10 alkyl; R2 is —H, C1 to C10 alkyl, —Cl, or —OCH2CH2OH; a is 1 to 5; b is 1 to 5; and w is 0, 1 or 2.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 15, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Neville Everton Drysdale
  • Patent number: 8722741
    Abstract: The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: May 13, 2014
    Assignee: AstraZeneca AB
    Inventors: Timothy Jon Luker, Timothy Nicholas Birkinshaw, Rukhsana Tasneem Mohammed
  • Patent number: 8669209
    Abstract: Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: March 11, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Franklin N. Keeney, Neil A. Foster, Martin C. Logan, Maria G. Perry
  • Publication number: 20130316907
    Abstract: A process for the preparation of solid amine salts of aromatic substituted carboxylic acid herbicides by reaction of the aromatic substituted carboxylic acid herbicide with an amine comprising reacting the aromatic substituted carboxylic acid herbicide in an ether solvent with an amine to form the amine salt and collecting the amine salt of the aromatic substituted carboxylic acid herbicide as a precipitate from the ether solvent reaction mixture wherein the ether is a dialiphatic ether comprising at least one primary aliphatic group.
    Type: Application
    Filed: May 11, 2011
    Publication date: November 28, 2013
    Applicant: NUFARM AUSTRALIA LIMITED
    Inventor: Eduard Kravets
  • Patent number: 8399518
    Abstract: Methods and compositions are disclosed for stimulating weight loss and/or lowering triglyceride levels in an individual mammal in need thereof. In an exemplary method, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or more lipid-reducing agents, is administered to an individual mammal to stimulate weight loss, and/or reduce levels of triglyceride and/or lipoprotein in the mammal.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: March 19, 2013
    Assignees: University of Arizona Office of Technology Transfer, The United States of America as Represented by the Department of Veterans Affairs
    Inventors: Eugene Morkin, Louis R. Bucalo, Steven Goldman
  • Publication number: 20130045869
    Abstract: Complexes of herbicidal carboxylic acids and amine-containing polymers or oligomers are provided. These herbicidal complexes are useful for controlling unwanted plant growth. The herbicidal complexes have low solubility in water, low volatility relative to commercial compositions of the corresponding herbicidal carboxylic acids, and offer similar or improved herbicidal performance when compared to existing salts of the herbicidal carboxylic acids.
    Type: Application
    Filed: August 15, 2012
    Publication date: February 21, 2013
    Applicant: Dow AgroSciences LLC
    Inventors: Lei Liu, Hong Zhang, Alex Kennedy, Holger Tank, David G. Ouse, James M. Gifford, Min Zhao
  • Publication number: 20130035446
    Abstract: The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals comprising a main chain and a side chain, wherein the side chain comprises a difluoromethylene group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).
    Type: Application
    Filed: April 19, 2011
    Publication date: February 7, 2013
    Applicant: ROLIC AG
    Inventors: Jean-Francois Eckert, Satish Palika, Andreas Schuster
  • Patent number: 8350099
    Abstract: Disclosed are fluorovinyl ether functionalized aromatic diesters and derivatives thereof. The compounds disclosed have utility as functionalized monomers and comonomers in polyesters, polyamides, and the like. It has been found that incorporation of the monomers into polymers provides improved soil resistance to shaped articles produced from the polymers.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: January 8, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Neville Everton Drysdale, Surbhi Mahajan, Kenneth Gene Moloy, Fredrik Nederberg, Joel M. Pollino, Joachim C. Ritter
  • Patent number: 8338637
    Abstract: Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: December 25, 2012
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Vinh X. Ngo
  • Publication number: 20120264603
    Abstract: The invention encompasses formulations for increased attachment and retention systems of biologically active organic compounds and methods for the preparation and use thereof.
    Type: Application
    Filed: October 7, 2011
    Publication date: October 18, 2012
    Inventors: David S. Soane, Gangadhar Jogikalmath
  • Publication number: 20120245213
    Abstract: Methods and compositions are provided for modulating the activity of human type I taste receptor subunit 3 (hT1R3). Such materials and methods are useful for the screening and preparation of compositions and methods for the treatment of carbohydrate and lipid metabolic diseases and disorders.
    Type: Application
    Filed: October 1, 2010
    Publication date: September 27, 2012
    Inventors: Bedrich Mosinger, Emeline Maillet, Robert Margolskee
  • Publication number: 20120232079
    Abstract: The invention relates to novel acylpiperazinone compounds, to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.
    Type: Application
    Filed: October 20, 2010
    Publication date: September 13, 2012
    Inventors: Vincent Gerusz, Sonia Escaich, Mayalen Oxoby, Francois Moreau
  • Publication number: 20120225940
    Abstract: The present invention provides the use of (?) (3-trihalomethylphenoxy) (4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.
    Type: Application
    Filed: March 28, 2012
    Publication date: September 6, 2012
    Inventors: Kenneth L. Luskey, Jian Luo
  • Publication number: 20120184434
    Abstract: The present invention relates to a salt comprising an anionic pesticide and a cationic polyamine of the formula (A) or (B) as described in the description. The invention further relates to an agrochemical composition comprising said salt. It also relates to a method for preparing said salt comprising combining the pesticide in its neutral form or as salt, and the polyamine in its neutral form or as salt. In addition, the invention relates to a method of combating harmful insects and/or phytopathogenic fungi. It also relates to a method of controlling undesired vegetation. Finally, the invention relates to seed comprising said salt.
    Type: Application
    Filed: September 28, 2010
    Publication date: July 19, 2012
    Applicant: BASF SE
    Inventors: Wen Xu, Paul Ch. Kierkus, Steven Brunt, Steven Bowe, Adam Hixson, Terrance M. Cannan
  • Publication number: 20120165566
    Abstract: The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6 , n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.
    Type: Application
    Filed: March 5, 2012
    Publication date: June 28, 2012
    Inventors: Eric Marsault, Luc Ouellet, Hamid R. Hoveyda
  • Patent number: 8188148
    Abstract: The present invention concerns substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, particularly in the field of human and animal health.
    Type: Grant
    Filed: June 21, 2007
    Date of Patent: May 29, 2012
    Assignee: Genfit
    Inventors: Jean-François Delhomel, Rémy Hanf, Karine Caumont-Bertrand
  • Patent number: 8173704
    Abstract: The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: October 9, 2006
    Date of Patent: May 8, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Stephan Bartel, Michael Hahn, Wahed Ahmed Moradi, Eva-Maria Becker, Thomas Rölle, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Andreas Knorr
  • Publication number: 20120076952
    Abstract: A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.
    Type: Application
    Filed: December 1, 2011
    Publication date: March 29, 2012
    Applicant: ROLIC AG
    Inventors: Thomas BACHELS, Zoubair Mohammed CHERKAOUI, Guy MARCK, Olivier MULLER, Joachim REICHARDT, Andreas SCHUSTER, Hubert SEIBERLE, Peggy STUDER, Thomas PEGLOW, Jean-François ECKERT
  • Publication number: 20110306498
    Abstract: The present invention provides a method and a composition for restoring pollen fertility by suppressing formation insufficiency in a pollen formation process due to a high-temperature or low-temperature stress. The present invention provides a fertility restorative agent comprising an auxin as an active ingredient, and a method for restoring the fertility of a plants of the family Poaceae, comprising spreading an auxin. Moreover, the present invention provides a fertility restorative agent containing as an active ingredient a substance which inhibits auxin action, and a method for restoring the fertility of rice plant, including spreading a substance which inhibits auxin action.
    Type: Application
    Filed: July 8, 2011
    Publication date: December 15, 2011
    Inventors: Atsushi Higashitani, Masao Watanabe, Tadashi Sakata
  • Publication number: 20110281898
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: July 26, 2011
    Publication date: November 17, 2011
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • Patent number: 8049035
    Abstract: This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: November 1, 2011
    Assignee: Bayer Pharma AG
    Inventors: Tilo Haag, Danja Grossbach, Gabriele Winter, Michael Sander, Wolfgang Beckmann, Klaus Bartel, Christian Dinter
  • Patent number: 8008525
    Abstract: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
    Type: Grant
    Filed: November 26, 2004
    Date of Patent: August 30, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Kohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
  • Patent number: 8008523
    Abstract: A process for preparing monocarboxylic perfluoropolyethers of formula: A-O—(RF)z—(CFY)t—C(O)OX (I) wherein: X is H, C1-C10 alkyl, or an aryl group; Y=F, CF3; t=1, 2 or 3; A is a C1-C4 perfluoroalkyl end group; z=0 or 1; RF is a perfluorooxyalkylene chain; having a number average molecular weight in the range 180-8,000; comprising the following steps: a) one or more distillations of perfluoropolyethers (PFPE) of formula T-O—(RF)z-T? (II) wherein: z and RF are as above defined; T, T?, equal to or different from each other, are selected from acyl fluoride or carbonyl-containing functional end groups and non functional end groups to obtain one PFPE fraction of formula (II) wherein the difference between the minimum and the maximum molecular weight of the components is lower than or equal to 600; b) partial fluorination of the fraction obtained in a); c) esterification c1) and/or hydrolysis c2) of the mixture obtained in b); d) distillation of the product obtained in c2) or in c1).
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: August 30, 2011
    Assignee: Solvay Solexis S.p.A.
    Inventors: Giuseppe Marchionni, Ugo De Patto, Pier Antonio Guarda
  • Publication number: 20110166117
    Abstract: The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 30, 2010
    Publication date: July 7, 2011
    Inventors: Roger Bonnert, Stephen Brough, Andrew Davies, Timothy Luker, Thomas McInally, Ian Millichip, Garry Pairaudeau, Anil Patel, Rukhsana Rasul, Stephen Thom
  • Publication number: 20110152373
    Abstract: The present invention provides a new pharmaceutical application of a 15,15-difluoroprostaglandin F2? derivative. As a result of intensive studies in order to find a new pharmaceutical application of a 15,15-difluoroprostaglandin F2? derivative, it was found that, in a European Phase III clinical trial for tafluprost, one of the 15,15-difluoroprostaglandin F2? derivatives, with patients with open-angle glaucoma or ocular hypertension, tafluprost has actions of growing eyelashes, making eyelashes thicker, and changing the color thereof, that is, has an effect of promoting the growth of hair (eyelashes). Therefore, a 15,15-difluoroprostaglandin F2? derivative is useful as a hair growth promoting agent, and is expected to be useful as an active ingredient of a preventive or therapeutic agent for a disease associated with hair such as alopecia and a hair care product or a hair cosmetic product for regrowing hair, growing hair, increasing hair density, nourishing hair, or the like.
    Type: Application
    Filed: September 4, 2009
    Publication date: June 23, 2011
    Applicant: SANTAN PHARMACEUTICAL CO., LTD.
    Inventor: Auli Ropo
  • Publication number: 20110152374
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: December 20, 2010
    Publication date: June 23, 2011
    Inventors: Timothy Jon Luker, Rukhsana Tasneem Mohammed, Mark Dickinson, Stephen Thom
  • Patent number: 7906678
    Abstract: This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.
    Type: Grant
    Filed: December 3, 2007
    Date of Patent: March 15, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Tilo Haag, Danja Grossbach, Gabriele Winter, Michael Sander, Wolfgang Beckmann, Klaus Bartel, Christian Dinter
  • Publication number: 20110060116
    Abstract: New fluorinated ethers of aromatic acids and diesters are disclosed. These compositions can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 10, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, Surbhi Mahajan Du, Kenneth Gene Moloy, Joel M. Pollino, Joachim C. Ritter
  • Publication number: 20100286276
    Abstract: The present invention concerns substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, particularly in the field of human and animal health.
    Type: Application
    Filed: June 21, 2007
    Publication date: November 11, 2010
    Applicant: GENFIT
    Inventors: Jean-Fancois Delhomel, Rémy Hanf, Karine Caumont-Bertrand
  • Publication number: 20100234464
    Abstract: 3-(2,4-Bis(trifluoromethyl)benzyloxy)phenylacetic acid, 4-(2,6-Dimethylbenzyloxy)-phenylacetic acid, and their pharmaceutically acceptable salts are useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis.
    Type: Application
    Filed: June 8, 2007
    Publication date: September 16, 2010
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 7737176
    Abstract: The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: June 15, 2010
    Assignee: Merck Patent GmbH
    Inventors: Michel Brunet, Jean-Jacques Zeiller, Gérard Ferrand, Yves Bonhomme
  • Publication number: 20100105775
    Abstract: The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.
    Type: Application
    Filed: October 29, 2008
    Publication date: April 29, 2010
    Inventors: Mitchell A. DeLong, Jill Marie Sturdivant
  • Patent number: 7635718
    Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: December 22, 2009
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan R. DeAngelis
  • Patent number: 7547729
    Abstract: The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a method for preparing said derivatives.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: June 16, 2009
    Assignee: Genfit
    Inventors: Karine Caumont-Bertrand, Jean-François Delhomel
  • Publication number: 20090111859
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Application
    Filed: April 10, 2008
    Publication date: April 30, 2009
    Applicant: Amgen Inc.
    Inventors: Sean P. Brown, Paul Dransfield, Zice Fu, Jonathan Houze, Xian Yun Jiao, Todd J. Kohn, Vatee Pattaropong, Marc Vimolratana, Michael J. Schmitt
  • Patent number: 7504435
    Abstract: Administration of a therapeutically effective amount of 3,5-diiodothyropropionic acid stimulates weight loss in patients, lowers triglyceride levels and reduces risk of death or progression of coronary heart disease in patients with metabolic syndrome.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: March 17, 2009
    Assignee: The Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Cynthia R. Adamson, legal representative, Steven Goldman, Eugene Morkin
  • Publication number: 20090048257
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPAR? and should be useful for treating conditions mediated by the same.
    Type: Application
    Filed: March 7, 2007
    Publication date: February 19, 2009
    Inventor: Per Sauerberg
  • Patent number: 7465752
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: December 16, 2008
    Assignee: Merck Patent GmbH
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Patent number: 7465804
    Abstract: The present invention provides compounds useful, for example, for modulating insulin levels in a subject, having the general formula I: wherein Q is an optionally substituted phenyl; L is a bond or O; P is a benzene or an optionally substituted thiazole ring; and R1 has the values provided herein. The present invention also provides compositions, uses, and methods for use of the compounds, for instance, for treatment of type II diabetes.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: December 16, 2008
    Assignee: Amgen Inc.
    Inventors: Jonathan Houze, Jiwen Liu, Zhihua Ma, Julio C. Medina, Michael J. Schmitt, Rajiv Sharma, Ying Sun, Yingcai Wang, Liusheng Zhu
  • Publication number: 20080275270
    Abstract: A process for preparing a quaternary ammonium salt of a fibric acid, represented by the following reaction scheme: is carried out in a single operation starting from a phenol of formula (I), an ?-halogenated ester of formula (II) and a quaternary ammonium hydroxide of formula (III). This process makes it possible economically to prepare a choline salt of fenofibric acid in high purity that can be used directly as the active substance in a pharmaceutical composition intended for human consumption.
    Type: Application
    Filed: April 28, 2008
    Publication date: November 6, 2008
    Applicant: Fournier Laboratories Ireland Ltd
    Inventors: Philippe Dellis, Kamel Nasar
  • Patent number: 7432394
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: October 7, 2008
    Assignee: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • Patent number: 7429669
    Abstract: Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: September 30, 2008
    Assignee: Allergan, Inc.
    Inventors: David W. Old, Vinh X. Ngo
  • Publication number: 20080233606
    Abstract: Provided herein are assays for detecting enzyme activity using Raman Spectroscopy.
    Type: Application
    Filed: April 22, 2008
    Publication date: September 25, 2008
    Inventors: Mustapha Haddach, Gregory S. Naeve
  • Publication number: 20080167378
    Abstract: An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.
    Type: Application
    Filed: November 26, 2004
    Publication date: July 10, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Kohji Fukatsu, Ryo Fujii, Makoto Kobayashi, Jinichi Yonemori, Toshio Tanaka
  • Patent number: 7385082
    Abstract: The invention relates to a method for the preparation of de 1,3-diphenylprop-2-en-1-one substituted on one of the two phenyl groups by a carboxyalkyloxy group or a carboxyalkylthio group.
    Type: Grant
    Filed: July 8, 2004
    Date of Patent: June 10, 2008
    Assignee: GENFIT
    Inventors: Jean-François Delhomel, Karine Caumont-Bertrand
  • Publication number: 20080064748
    Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of ?-aminobutyric acid (GABA) on the GABAA receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABAA receptor complex.
    Type: Application
    Filed: May 5, 2005
    Publication date: March 13, 2008
    Inventors: Derk J. Hogenkamp, Timothy B.C. Johnstone, Kelvin W. Gee