Plural Rings Patents (Class 562/488)
  • Patent number: 11161960
    Abstract: A method for rotary die cutting. The method may include providing, to an accumulator, an input comprising a melt. The method may include processing, by the accumulator utilizing a set of rolls, the melt to form a sheet of material. The method may include providing, from the accumulator, the sheet of material to a dandy roll. The method may include providing, from the dandy roll, the sheet of material to a rotary die. The method may include cutting, by the rotary die, a product from the sheet of material. The method may include providing, from the rotary die, the product to a stacker.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: November 2, 2021
    Assignee: OCTAL SAOC FZC
    Inventors: Tarun Joshi, Muteeb Siddiqui, Klaus Haarmann, Jerry Bradnam, Sean Brown, Mohammed Razeem, William J. Barenberg, Nicholas P. Barakat
  • Patent number: 10598658
    Abstract: A reduced graphene oxide-based biosensor includes a nano-structure field-effect transistor including a channel region which includes a reduced graphene oxide having a linking moiety to be bonded to a receptor specific to an analyte, and which is represented by a formula of —(C?O)—X—COOH, wherein X represents a C1-C3 alkenylene group or a C1-C3 alkylene group.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: March 24, 2020
    Assignee: Chang Gung University
    Inventors: Mu-Yi Hua, Hsiao-Chien Chen, Yi-Ting Chen, Rung-Ywan Tsai, Min-Cheng Chen, Chien-Lun Chen
  • Patent number: 10029215
    Abstract: The present invention relates to a technology for manufacturing a nanocomposite membrane comprising a graphene oxide coating layer with a thickness of 1 nm to 50 nm, which is formed on various supports and has nanopores, and a reduced graphene oxide nanocomposite membrane, and applying the membranes to gas separation. The graphene oxide nanocomposite membrane for gas separation of the present invention has excellent gas permeability and selectivity at the same time, and especially, excellent hydrogen gas permeability and hydrogen gas selectivity compared with carbon dioxide, and the reduced graphene oxide nanocomposite membrane has remarkably enhanced hydrogen gas permeability and hydrogen gas selectivity compared with carbon dioxide, and thus the membranes are applicable as a gas separation membrane in an industrial field involving a hydrogen separation process.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: July 24, 2018
    Assignee: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
    Inventors: Ho Bum Park, Hyo Won Kim, Myung Jin Yoo, Byung Min Yoo, Byungkook Ahn
  • Patent number: 10016725
    Abstract: A forward osmosis process is provided, which includes separating a feed part and a draw solution part by a semi-permeable film. An ionic liquid is introduced into the draw solution part, and brine is introduced into the feed part. The brine has an osmotic pressure lower than that of the ionic liquid, so that pure water of the brine permeates through the semi-permeable film, enters the draw solution part, and mixes with the ionic liquid to form a draw solution. The draw solution was obtained out of the draw solution part to be left to stand at room temperature, so that the draw solution separated into a water layer and an ionic liquid layer.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: July 10, 2018
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Po-I Liu, Li-Ching Chung, Chih-Hsiang Fang, Chia-Hua Ho, Hsin Shao, Meng-Shun Huang, Ren-Yang Horng, Teh-Ming Liang, Min-Chao Chang, Tsui Jung Yang
  • Patent number: 9738591
    Abstract: A compound for use as an antimicrobial having a formula (A).
    Type: Grant
    Filed: January 8, 2015
    Date of Patent: August 22, 2017
    Inventor: Ramiz Boulos
  • Publication number: 20150135993
    Abstract: A method of treating particles by disaggregating, deagglomerating, exfoliating, cleaning, functionalising, doping, decorating and/or repairing said particles, in which the particles are subjected to plasma treatment in a treatment chamber containing a plurality of electrodes which project therein and wherein plasma is generated by said electrodes which are moved during the plasma treatment to agitate the particles.
    Type: Application
    Filed: November 12, 2014
    Publication date: May 21, 2015
    Inventors: John Buckland, Dylan Walters
  • Publication number: 20150126773
    Abstract: Synthetic alkylated graphenes of well chosen structure are prepared and used for mimicking indigenous asphaltenes. The mixtures can be used as multiphase flow test fluids in general and specifically in the Oil and gas industry.
    Type: Application
    Filed: April 25, 2013
    Publication date: May 7, 2015
    Inventor: Vincent Olivier Pauchard
  • Publication number: 20150065711
    Abstract: Disclosed are linear discrete PEG constructs, which can be created and produced in a precise and reproducible way. Key to being able to do these things, where x in the discrete PEGx can vary from about 2 to about 64, is that the processes used to make each linear portion is controlled to give essentially one oligomer/one compound. Having a variable length linear discrete PEG construct that is (a) primarily an linear discrete PEG construct with diagnostic or therapeutic groups attached along a chain of attachment cores, which is attached to a preferential locator; (b) is an m-discrete PEG as the terminal construct on the linear portion, and “hidden”; (c or linear discrete PEG with a terminus group that can be either negatively or positively charged, or neutral; and any of the discrete PEG portions can be designed to be cleaved after entering the cell.
    Type: Application
    Filed: August 15, 2014
    Publication date: March 5, 2015
    Applicant: EquIP, LLC
    Inventor: Paul D. Davis
  • Patent number: 8969554
    Abstract: Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides. The compounds are triazine derivatives represented by following Formula 1 or salts thereof, and the herbicides containing them: [Chem. 28] wherein in the formula, R1 represents a hydrogen atom; a C1-C12 alkyl group; a C2-C6 alkenyl group, etc., R2 represents a C1-C12 alkyl group, etc., Y and Z represent an oxygen atom or a sulfur atom, and A represents a 5- or 6-membered cyclic group which may contain a nitrogen atom, an oxygen atom, or a sulfur atom.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 3, 2015
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Atsushi Shibayama, Ryu Kajiki, Masami Kobayashi, Takashi Mitsunari, Atsushi Nagamatsu
  • Publication number: 20140319404
    Abstract: The present invention relates to the use of certain substituted fullerenes in optoelectronic devices, preferably in photovoltaic cells, preferably in organic photovoltaic cells especially preferred in a two-component electron-selective buffer layer of an organic photovoltaic cell to improve the efficiency of solar cells for energy generation.
    Type: Application
    Filed: July 3, 2012
    Publication date: October 30, 2014
    Applicant: LANXESS DEUTSCHLAND GMBH
    Inventors: Roman Evgenievich Levin, Alexey Borisovich Kornev, Pavel Anatolyevich Troshin, Vladimir Fedorovich Razumov
  • Publication number: 20140275605
    Abstract: A composition is described comprising a mixture of (methylcyclohexyl)toluene isomers having the following formula: wherein the mixture comprises at least 50 wt % in total of the 3,3, 3,4 4,3 and 4,4-isomers of (methylcyclohexyl)toluene.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Inventors: Jihad M. Dakka, Lorenzo C. DeCaul, Wei Tang
  • Publication number: 20140163107
    Abstract: A pharmaceutical composition for treating viral infections by an influenza type A virus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein. A pharmaceutical composition for treating viral infections by an orthomyxovirus, includes a compound capable of acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of orthomyxoviruses, and capable of binding to the viral-RNA-binding domain on the nucleoprotein of the viruses. A compound acting as an inhibitor of the binding of the viral RNA to the nucleoprotein of influenza type A viruses, and binding to the viral-RNA-binding domain on the nucleoprotein of influenza type A viruses and a method for identifying such a compound having these properties are also described.
    Type: Application
    Filed: April 20, 2012
    Publication date: June 12, 2014
    Applicant: Institut National de la Recherche Agronimique
    Inventors: Anny Slama Schwok, Bernard Delmas, Stephane Quideau, Helene Bertrand, Bogdan Tarus
  • Publication number: 20140005428
    Abstract: A metal organic framework (MOF) material including a Brunauer-Emmett-Teller (BET) surface area greater than 7,010 m2/g. Also a metal organic framework (MOF) material including hexa-carboxylated linkers including alkyne bond. Also a metal organic framework (MOF) material including three types of cuboctahedron cages fused to provide continuous channels. Also a method of making a metal organic framework (MOF) material including saponifying hexaester precursors having alkyne bonds to form a plurality of hexa-carboxylated linkers including alkyne bonds and performing a solvothermal reaction with the plurality of hexa-carboxylated linkers and one or more metal containing compounds to form the MOF material.
    Type: Application
    Filed: June 18, 2013
    Publication date: January 2, 2014
    Applicant: Northwestern University
    Inventors: Omar K. Farha, Joseph T. Hupp, Christopher E. Wilmer, Ibrahim Eryazici, Randall Q. Snurr, Diego A. Gomez-Gualdron, Bhaskarjyoti Borah
  • Publication number: 20130345249
    Abstract: The invention encompasses pharmaceutical formulations for the prevention and treatment of Wolbachia-related disease wherein the formulations comprise a compound previously unknown and unused for such a purpose, the compound being one or more of: Pararosaniline Pamoate, Pyrvinium Pamoate, Clofoctol, and Isoreserpine, derivatives, metabolites, precursors, pro-drugs and variants thereof.
    Type: Application
    Filed: January 13, 2012
    Publication date: December 26, 2013
    Applicant: The Regents of the University of California
    Inventors: Alain Debec, Laura Serbus, Frederic Landmann, William Sullivan
  • Patent number: 8609727
    Abstract: The present application relates to novel dicarboxylic acid derivatives, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: December 17, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Stephan Bartel, Michael Hahn, Wahed Ahmed Moradi, Eva-Maria Becker, Thomas Rölle, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Andreas Knorr, Dieter Lang
  • Publication number: 20130237723
    Abstract: Provided are a fluorinated graphene oxide and a preparation method thereof. In the fluorinated graphene oxide, the mass percent of fluorine is 0.5%<F %<40%; the mass percent of carbon is 50%<C %<80%, and the mass percent of oxygen is 0.5%<0%<30%. The preparation method comprises the following steps: providing graphite; preparing graphene oxide by using the graphite; and subjecting the graphene oxide to reacting with a mixed gas of N2 and F2 at 20˜200° C. for 0.5˜24 h, to prepare the fluorinated graphene oxide. The preparation method is simple, has fewer steps, and has better prospect of application.
    Type: Application
    Filed: December 22, 2010
    Publication date: September 12, 2013
    Inventors: Mingjie Zhou, Daxi Liu, Yaobing Wang
  • Publication number: 20130232853
    Abstract: The present invention is directed generally to a method of production of biobased chemicals, biofuels, and lignin residues from lignin sources, including waste lignin. This method may allow for selectively producing biobased chemicals, biofuels, and lignin residues from lignin sources using certain processing methods. The methods for production of these biobased chemicals, biofuels, and lignin residues may be provided by chemical-induced processing, catalytic oxidative lignin depolymerisation processing, and catalytic hydroprocessing. Further, the catalytic hydroprocessing from processes including catalytic reduction processing, catalytic hydrodeoxygenation processing, and/or catalytic/dehydrogenation processing may also be used. The method described herein also provides a means in which waste from the process(es) may be reduced and/or recycled.
    Type: Application
    Filed: May 14, 2012
    Publication date: September 12, 2013
    Applicant: THESIS CHEMISTRY, LLC
    Inventors: John R. Peterson, Jignesh S. Patel, Vladimir Romakh, Benjamin M.T. Scott
  • Patent number: 8470075
    Abstract: Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: June 25, 2013
    Assignee: Northwestern University
    Inventors: Omar K. Farha, Joseph T. Hupp
  • Publication number: 20130137894
    Abstract: A chemically-modified graphene includes a graphene layer and a plurality of functional groups that are grafted to the graphene layer and each of which is represented by —CO—R—COOH, wherein R is an optionally substituted C1-C5 alkylene group or an optionally substituted C1-C5 alkenylene group. A method for producing a chemically-modified grapheme includes subjecting a cyclic anhydride and graphite to a Friedel-Crafts reaction in the presence of a Lewis acid.
    Type: Application
    Filed: September 14, 2012
    Publication date: May 30, 2013
    Applicant: Chang Gung University
    Inventors: Mu-Yi Hua, Shi-Liang Chen, Hsiao-Chien Chen, Rung-Ywan Tsai, Wu-Shiung Feng, Ming-Jer Jeng
  • Patent number: 8426636
    Abstract: A sterically bulky stabilizer that is associated non-covalently with a benzimidazolone pigment. The sterically bulky stabilizer compound includes an aromatic acid derivative, and the presence of the sterically bulky stabilizer limits an extent of particle growth and aggregation, to afford nanoscale pigment particles.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: April 23, 2013
    Assignees: Xerox Corporation, National Research Council of Canada
    Inventors: Rina Carlini, Darren Andrew Makeiff
  • Publication number: 20130079552
    Abstract: The present invention relates to a novel graphene oxide reducing agent and a method for manufacturing a reduced graphene oxide from graphene oxide using same. More particularly, in the present invention, the reduced graphene oxide is manufactured by reducing a graphene oxide using a reducing agent containing a halogen element, and is applicable as an electric conductor, a semiconductor, and an insulator in various fields.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 28, 2013
    Inventors: Hyo Young Lee, In Kyu Moon, Jung Hyun Lee
  • Publication number: 20130072669
    Abstract: The present invention is directed to carbon nanostructures, e.g., carbon nanotubes, methods of covalently functionalizing carbon nanostructures, and methods of separating and isolating covalently functionalized carbon. In some embodiments, carbon nanotubes are reacted with alkylating agents to provide water soluble covalently functionalized carbon nanotubes. In other embodiments, carbon nanotubes are reacted with a thermally-responsive agent and exposed to light in order to separate carbon nanotubes of a specific chirality from a mixture of carbon nanotubes.
    Type: Application
    Filed: April 4, 2012
    Publication date: March 21, 2013
    Applicant: University of Maryland, College Park
    Inventors: YuHuang Wang, Alexandra H. Brozena, Shunliu Deng, Yin Zhang
  • Publication number: 20130061752
    Abstract: Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation.
    Type: Application
    Filed: September 10, 2012
    Publication date: March 14, 2013
    Applicant: Northwestern University
    Inventors: Omar K. Farha, Joseph T. Hupp
  • Publication number: 20130053573
    Abstract: New triaminophenol compositions and related compounds are disclosed, as are processes for their preparation and for the preparation of novel salts and diacid complexes from such compounds. Polymers prepared from these compositions can be made into high strength fiber, film, and tape and are useful in applications such as protective apparel, aircraft, automotive components, personal electronics, and sports equipment.
    Type: Application
    Filed: December 21, 2010
    Publication date: February 28, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8383545
    Abstract: A linking ligand compound includes three bidentate chemical moieties distributed about a central chemical moiety. Another linking ligand compound includes a bidentate linking ligand and a monodentate chemical moiety. Coordination polymers include a plurality of metal clusters linked together by residues of the linking ligand compounds.
    Type: Grant
    Filed: August 30, 2007
    Date of Patent: February 26, 2013
    Assignee: The Regents of the University of Michigan
    Inventors: Adam J. Matzger, Antek G. Wong-Foy, Olivier Lebel
  • Patent number: 8362295
    Abstract: Drilling fluids comprising graphenes and nanoplatelet additives and methods for production thereof are disclosed. Graphene includes graphite oxide, graphene oxide, chemically-converted graphene, and functionalized chemically-converted graphene. Derivatized graphenes and methods for production thereof are disclosed. The derivatized graphenes are prepared from a chemically-converted graphene through derivatization with a plurality of functional groups. Derivatization can be accomplished, for example, by reaction of a chemically-converted graphene with a diazonium species. Methods for preparation of graphite oxide are also disclosed.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: January 29, 2013
    Assignee: William Marsh Rice University
    Inventors: James M. Tour, Howard K. Schmidt, Condell D. Doyle, Dmitry V. Kosynkin, Jay R. Lomeda
  • Publication number: 20120329871
    Abstract: A compound for use as an antimicrobial having a formula (A).
    Type: Application
    Filed: December 21, 2010
    Publication date: December 27, 2012
    Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA
    Inventors: Allan James McKinley, Thomas V. Riley, Nigel Lengkeek, Scott Stewart, Ramiz Boulos
  • Publication number: 20120309833
    Abstract: The present invention relates to analogs of bexarotene and methods of use thereof.
    Type: Application
    Filed: February 17, 2011
    Publication date: December 6, 2012
    Inventors: Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall, Arjan van der Vaart
  • Publication number: 20120289711
    Abstract: The present invention relates to a method for producing carbon nanomaterials and/or carbon micromaterials, in particular multi-wall carbon nanotubes. This method is characterized according to the invention in that the materials, in particular the side walls of the materials, undergo microwave-assisted functionalization. In addition, a correspondingly modified material is described.
    Type: Application
    Filed: October 25, 2010
    Publication date: November 15, 2012
    Applicant: FUTURECARBON GMBH
    Inventors: Jens Helbig, Christian Zenkel
  • Patent number: 8262775
    Abstract: Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: September 11, 2012
    Assignee: Northwestern University
    Inventors: Omar K. Farha, Joseph T. Hupp
  • Publication number: 20120183770
    Abstract: The present invention relates to the exfoliation and dispersion of carbon nanotubes resulting in high aspect ratio, surface-modified carbon nanotubes that are readily dispersed in various media. A method is disclosed for their production in high yield. Further modifications by surface active or modifying agents are also disclosed. Application of the carbon nanotubes of this invention as composites with materials such as elastomers, thermosets and thermoplastics are also described.
    Type: Application
    Filed: June 20, 2011
    Publication date: July 19, 2012
    Inventors: Clive P. Bosnyak, Kurt W. Swogger
  • Publication number: 20120170118
    Abstract: Presently described are multilayer optical films, oriented polyester films, negatively birefringent copolyester polymers, fluorene monomers, and polyester polymers prepared from such fluorene monomers. In one embodiment, the multilayer optical film comprises at least one first birefringent optical layer; and at least one second optical layer having a lower birefringence than the first optical layer; wherein at least one of the optical layers comprises a negatively birefringent polyester polymer comprising a backbone and repeat units comprising at least one pendent aromatic group that is conformationally locked relative to the backbone.
    Type: Application
    Filed: November 23, 2011
    Publication date: July 5, 2012
    Inventors: Lei Wang, David T. Yust, George W. Griesgraber, Stephen A. Johnson, David S. Hays
  • Patent number: 8173351
    Abstract: A compound shown by the following formula (1) can be used as a material for a radiation-sensitive composition capable of forming a resist film which effectively responds to electron beams or the like, exhibits low roughness, and can form a high precision minute pattern in a stable manner.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: May 8, 2012
    Assignee: JSR Corporation
    Inventors: Daisuke Shimizu, Ken Maruyama, Toshiyuki Kai, Tsutomu Shimokawa
  • Publication number: 20120101250
    Abstract: A dehydroabietic acid polymer includes a repeating unit containing a dehydroabietic acid skeleton, and a composite material including the same.
    Type: Application
    Filed: June 24, 2010
    Publication date: April 26, 2012
    Applicant: FUJIFILM CORPORATION
    Inventors: Toshimitsu Sakuma, Kozo Sato
  • Patent number: 8106236
    Abstract: The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of ?-secretase activity.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: January 31, 2012
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Francis Wilson, Alison Reid, Valerie Reader, Richard John Harrison, Mihiro Sunose, Remedios Hernandez-Perni, Jeremy Major, Cyrille Boussard, Kathryn Smelt, Jess Taylor, Adeline LeFormal, Andrew Cansfield, Svenja Burckhardt, Yan Zhang, Chih Yung Ho
  • Publication number: 20110301305
    Abstract: According to the present invention, a polymer is obtained by polycondensation of a fluorinated dicarboxylic acid derivative of the general formula (M-1) or an acid anhydride of the fluorinated dicarboxylic acid with a polyfunctional compound having two to four reactive groups corresponding in reactivity to carbonyl moieties of the fluorinated dicarboxylic acid derivative or acid anhydride. [Chem. 134] AOCF2C-Q-CF2COA???(M-1) In the above formula, Q represents a divalent organic group having a substituted or unsubstituted aromatic ring; and A and A? each independently represent an organic group. This polymer exhibits a sufficiently low dielectric constant for use as a semiconductor protection film and has the capability of forming a film at a relatively low temperature of 250° C. or lower.
    Type: Application
    Filed: February 18, 2010
    Publication date: December 8, 2011
    Applicant: CENTRAL GLASS COMPANY, LIMITED
    Inventors: Yoshimi Isono, Satoru Narizuka, Hidehisa Nanai, Kazuhiro Yamanaka
  • Patent number: 8067466
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: November 29, 2011
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Daniela Carmen Oniciu
  • Patent number: 7985876
    Abstract: The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
    Type: Grant
    Filed: March 15, 2008
    Date of Patent: July 26, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Michael Hahn, Eva-Maria Becker, Andreas Knorr, Dirk Schneider, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Dieter Lang
  • Publication number: 20110144386
    Abstract: Drilling fluids comprising graphenes and nanoplatelet additives and methods for production thereof are disclosed. Graphene includes graphite oxide, graphene oxide, chemically-converted graphene, and functionalized chemically-converted graphene. Derivatized graphenes and methods for production thereof are disclosed. The derivatized graphenes are prepared from a chemically-converted graphene through derivatization with a plurality of functional groups. Derivatization can be accomplished, for example, by reaction of a chemically-converted graphene with a diazonium species. Methods for preparation of graphite oxide are also disclosed.
    Type: Application
    Filed: January 8, 2009
    Publication date: June 16, 2011
    Applicant: William Marsh Rice University
    Inventors: James M. Tour, Howard K. Schmidt, Condell D. Doyle, Dmitry V. Kosynkin, Jay R. Lomeda
  • Publication number: 20110110886
    Abstract: Autotaxin (ATX) is a prometastatic enzyme initially isolated from the conditioned media of human melanoma cells that stimulates a myriad of biological activities including angiogenesis and the promotion of cell growth, survival, and differentiation through the production of lysophosphatidic acid (LPA). ATX increases the aggressiveness and invasiveness of transformed cells, and ATX levels directly correlate with tumor stage and grade in several human malignancies. To study the role of ATX in the pathogenesis of malignant melanoma, we developed antibodies and small molecule inhibitors against recombinant human protein. Immunohistochemistry of paraffin embedded human tissue demonstrates that ATX levels are markedly increased in human primary and metastatic melanoma relative to benign nevi. Chemical screens identified several small molecule inhibitors with binding constants ranging from nanomolar to low micromolar.
    Type: Application
    Filed: June 15, 2009
    Publication date: May 12, 2011
    Inventor: Demetrios Braddock
  • Publication number: 20110077298
    Abstract: The invention relates to a retinoid derivative and pharmaceutical composition and use thereof. The compound of the invention is capable of preventing or treating hematological tumours, such as acute leukemia, chronic leukemia, multiple myeloma and lymphoma, solid tumours, such as liver cancer, rectal cancer, mammary cancer and esophagus cancer, and skin disorders, such as psoriasis and acne.
    Type: Application
    Filed: May 31, 2009
    Publication date: March 31, 2011
    Applicants: ANHUI MEDICAL UNIVERSITY, Anhui New Star Pharmaceutical Development Co., Ltd
    Inventors: Feihu Chen, Jingbo Shi, Yuan Wang, Jun Li, Juan Shen, Jingjing Ruan, Fanrong Wu
  • Publication number: 20110068290
    Abstract: Compounds, compositions, systems and methods for the chemical and electrochemical modification of the electronic structure of graphene and especially epitaxial graphene (EG) are presented. Beneficially, such systems and methods allow the large-scale fabrication of electronic EG devices. Vigorous oxidative conditions may allow substantially complete removal of the EG carbon atoms and the generation of insulating regions; such processing is equivalent to that which is currently used in the semiconductor industry to lithographically etch or oxidize silicon and thereby define the physical features and electronic structure of the devices. However graphene offers an excellent opportunity for controlled modification of the hybridization of the carbon atoms from sp2 to sp3 states by chemical addition of organic functional groups.
    Type: Application
    Filed: May 29, 2009
    Publication date: March 24, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Robert C. Haddon, Mikhail E. Itkis, Palanisamy Ramesh, Elena Bekyarova, Sakhrat Khizroev, Jeongmin Hong
  • Publication number: 20110064892
    Abstract: This invention relates to polycyclic organic compounds of general structural formula (I): wherein Y is a predominantly planar polycyclic system being at least partially aromatic, W1, W2, and W3 are different groups providing solubility in an organic solvent, and sum (n1+n2+n3) is 1, 2, 3, 4, 5, 6, 7 or 8. The polycyclic organic compounds are substantially transparent for electromagnetic radiation in the visible spectral range and are capable of forming supramolecules in the organic solvent.
    Type: Application
    Filed: March 4, 2009
    Publication date: March 17, 2011
    Inventors: Alexey Nokel, Pavel I. Lazarev
  • Patent number: 7901745
    Abstract: 3,4-Dicarboxy-1,2,3,4-tetrahydro-6-t-butyl-1-naphthalene-succinic dianhydride is provided. The tetracarboxylic dianhydride is represented by Formula 1, which is described in the specification. Further provided is a liquid crystal aligning agent comprising a polyimide prepared using the tetracarboxylic dianhydride and a solvent. Further provided is a liquid crystal alignment layer formed using the liquid crystal aligning agent. The liquid crystal alignment layer exhibits excellent electro-optical properties and good processability in terms of printability.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 8, 2011
    Assignee: Cheil Industries Inc.
    Inventors: Jae Min Oh, Tae Hyoung Kwak, Ji Young Jeong
  • Publication number: 20110015426
    Abstract: A liquid crystalline compound has excellent liquid crystal properties, particularly high phase transition temperature. Diamantane compounds are represented by the general formula (I): (I) wherein A and B are each a six-membered, saturated or unsaturated, carbo- or hetero-cycle, and these cycles may have substituents, which substituents may be united to form a ring; and R1 and R2 are each a hydrocarbon group having 1 to 18 carbon atoms, and part of the carbon atoms of the hydrocarbon group may be replaced by heteroatoms or heteroatom-containing groups, while part of the hydrogen atoms thereof may be replaced by halogen atoms or heteroatom-containing groups.
    Type: Application
    Filed: March 11, 2008
    Publication date: January 20, 2011
    Applicants: NATIONAL UNIVERSITY CORPORATION YOKOHAMA, JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Yasushi Yokoyama, Tsuyoshi Gushiken, Takashi Ubukata
  • Publication number: 20100298347
    Abstract: Substituted 2-naphthoic acids of structural formula are effective as antagonists of the biological activity of GPR105 protein. They are useful for the treatment, control or prevention of disorders responsive to antagonism of this receptor, such as diabetes, particularly, Type 2 diabetes, insulin resistance, hyperglycemia, lipid disorders, obesity, atherosclerosis, and conditions associated with the Metabolic Syndrome.
    Type: Application
    Filed: December 1, 2008
    Publication date: November 25, 2010
    Applicant: MERCK FROSST CANADA LTD
    Inventors: Michel Belley, Denis Deschenes, Rejean Fortin, Jean-Francois Fournier, Sebastien Gagne, Yves Gareau, Jacques Yves Gauthier, Lianhai Li, Joel Robichaud, Michel Therien, Geoffrey K. Tranmer, Zhaoyin Wang
  • Patent number: 7816385
    Abstract: A novel class of dicarboxylic acid derivatives, the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator -Activated Receptors (PPAR).
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 19, 2010
    Assignee: High Point Pharmaceuticals, LLC
    Inventors: Per Sauerberg, Lone Jeppesen, Zdenek Polivka, Karel Sindelar
  • Publication number: 20100222543
    Abstract: Improved process for the continuous production of slow crystallizing polyester resin comprising esterification of at least one dicarboxylic acid or mono-esters thereof or di-esters thereof with at least one polyol, melt polymerizing the esterified mixture, preparing uniform crystalline hemispherical prepolymer by particle former process, adding at least one diol having tertiary or quaternary carbon atoms with pendant groups such as neopentyl glycol or 2-methyl-1,3-propanediol or any suitable diol at any stage during esterification or melt polymerization but before the particle former process; and solid state polymerizing the prepolymer to obtain high molecular weight slow crystallizing polyester. Slow crystallizing low molecular weight crystalline hemispherical prepolymer having IV of about 0.1 dl/g to about 0.45 and uniform hemispherical shape, uniform particle size, uniform crystallinity prepared by the above process and is used as precursor to prepare high molecular weight resin.
    Type: Application
    Filed: August 14, 2006
    Publication date: September 2, 2010
    Applicant: Reliance Industries Ltd
    Inventors: Vikas Madhusudan Nadkarni, Srinivasacharya Ramacharya Ayodhya, Shreeram Ashok Wadekar, Ashwin Kumar Jain, Sachin Narayan Rane, Chetan Vijay Limaye
  • Publication number: 20100204199
    Abstract: Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure: enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.
    Type: Application
    Filed: April 14, 2010
    Publication date: August 12, 2010
    Inventors: Xiang-Yang Ye, Jeffrey A. Robl, Ronald L. Hanson, Zhiwei Guo, Ramesh N. Patel
  • Publication number: 20100170395
    Abstract: Disclosed are tetratopic carboxylic acid phenyl for use in metal-organic framework compounds. These compounds are useful in catalysis, gas storage, sensing, biological imaging, drug delivery and gas adsorption separation.
    Type: Application
    Filed: October 13, 2009
    Publication date: July 8, 2010
    Inventors: Omar K. Farha, Joseph T. Hupp