Plural Rings Patents (Class 562/488)
-
Patent number: 4783548Abstract: A process for preparing a 3,4-dihydro 2-naphthanoic acid or an ester thereof comprises heating an alpha-vinyl cinnamic acid or a (C.sub.1 -C.sub.12)alkyl, (C.sub.6 -C.sub.12)aryl, (C.sub.6 -C.sub.12)aralkyl or (C.sub.6 -C.sub.12)alkylaryl ester thereof at a temperature effective to cyclize said acid or ester thereof and obtain the corresponding 3,4-dihydro 2-naphthanoic acid or ester thereof. The alpha-vinyl cinnamic acid or ester thereof may be obtained by contacting crotonic anhydride and a benzaldehyde substituted with halo or (C.sub.1 -C.sub.12)alkyl, acyl, acyloxy, carboxy, carbalkoxy, alkylthiol or alkoxy.A process for preparing 2-naphthanoic acid or an ester thereof comprises the above steps to prepare a 3,4-dihydro-2-naphthanoic acid, and dehydrogenating said 3,4-dihydro 2-naphthanoic acid or ester thereof to obtain the 2-naphthanoic acid.Type: GrantFiled: September 16, 1987Date of Patent: November 8, 1988Assignee: Eastman Kodak CompanyInventor: Joseph R. Zoeller
-
Patent number: 4727185Abstract: When a 4-halogenoorthophthalic acid salt is dissolved together with a base in an alkaline aqueous solution and the solution is heated in the presence of a catalyst comprising a noble metal supported on a carrier, a formic acid salt and a small amount of an aliphatic compound containing a hydroxyl group, a 3,3',4,4'-biphenyltetracarboxylic acid salt is obtained in a high yield.Type: GrantFiled: January 21, 1986Date of Patent: February 23, 1988Assignee: Hitachi, Ltd.Inventors: Fusaji Shoji, Fumio Kataoka
-
Patent number: 4720576Abstract: A process for dehalogeno-dimerization reaction of an aromatic halide compound which comprises dimerizing aromatic halide compound having at least one halogen atom attached to a carbon atom in the aromatic nucleus, and optionally having a substituent other than the halogen atom, in the presence of a platinum group metal catalyst, carbon monoxide, and an alkali metal compound and/or an alkaline earth metal compound.Type: GrantFiled: September 18, 1986Date of Patent: January 19, 1988Assignee: Mitsubishi Chemical Industries LimitedInventors: Keisuke Wada, Keiichi Sato
-
Patent number: 4716245Abstract: A process for producing 2,6-naphthalenedicarboxylic acid which comprises oxidizing 2,6-diisopropylnaphthalene or its oxidation derivative with molecular oxygen in a reaction medium containing at least 70% by weight of an aliphatic monocarboxylic acid selected from actic acid, propionic acid and a mixture of these in the presence of an oxidation catalyst comprising (A) at least one compound of a heavy metal element selected from cobalt and manganese and (B) bromine or a bromine compound; characterized in that said oxidation is carried out in the presence of 1.1 to 15 gram-atoms, per gram-atom of bromine, of an alkali metal.Type: GrantFiled: April 18, 1986Date of Patent: December 29, 1987Assignee: Teijin Petrochemical Industries, Ltd.Inventor: Isao Hirose
-
Patent number: 4689344Abstract: A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism, useful for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. The active compounds have the general formula ##STR1## or in-vivo hydrolyzable functional derivatives of the carboxylic groups thereof,whereinR.sub.1 and R.sub.2 each independently represents an unsubstituted or substituted hydrocarbyl or hetercyclyl radical;X and Y each independently represents hydrogen, optionally substituted lower alkyl, halogen, cyano, carboxy, lower alkoxycarbonyl or carbamoyl; andQ represents a diradical consisting of a linear chain of 8 to 14 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteratom chain members optionally forming part of a ring structure.Type: GrantFiled: June 22, 1984Date of Patent: August 25, 1987Assignee: Epis S.A.Inventor: Jacob Bar-Tana
-
Patent number: 4684744Abstract: Stilbene derivatives of the formula ##STR1## wherein X is chlorine or bromine, R.sub.1 is hydrogen, carboxyl, cyano, C.sub.1 -C.sub.6 -alkyl or a non-chromophorically esterified carboxyl group, and R.sub.2 and R.sub.3 independently of one another are each hydrogen, unsubstituted or non-chromophorically substituted C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.4 -alkenyl, or a non-chromophoric substituent of the 2nd order.They are valuable intermediates for producing optical brighteners of the 4,4'-disubstituted stilbene series.Type: GrantFiled: March 21, 1985Date of Patent: August 4, 1987Assignee: Ciga-Geiby CorporationInventors: Klaus Artz, Hans R. Meyer, Dieter Reinehr, Kurt Weber
-
Patent number: 4628125Abstract: A class of polyesters comprising recurring units having certain bis(trifluoromethyl)biphenylene radicals is disclosed. The polyesters exhibit favorable solubility properties in certain organic solvents so as to facilitate the production of the polyesters via polycondensation methods to film- and fiber-forming molecular weights. Monomeric compounds comprising a bis(trifluoromethyl)biphenylene radical and useful for the production of the polyesters are also disclosed.Type: GrantFiled: February 9, 1984Date of Patent: December 9, 1986Assignee: Polaroid Corporation, Patent Dept.Inventors: Howard G. Rogers, Russell A. Gaudiana, Richard A. Minns
-
Patent number: 4607116Abstract: Provided is a process for preparing a diaryl or a mixture of diaryls represented by any or a combination of the following formulae (II), (III) and (V), characterized in that a diaryliodonium salt represented by the following formula (I) is reacted in a solvent in the presence of a transition metal catalyst and a reducing metal at a temperature in the range of room temperature to 100.degree. C.:[Ar.sub.1 -I.sup..sym. -Ar.sub.2 ]X.sup..crclbar. (I)Ar.sub.1 -Ar.sub.1 (II)Ar.sub.1 -Ar.sub.2 (III)Ar.sub.2 -Ar.sub.2 (IV)wherein Ar.sub.1 and Ar.sub.2, which may be alike or different, are each an aryl group which may have a substituent group or groups and X.sup..crclbar. is a counter ion which is inert to said reaction.Type: GrantFiled: March 8, 1984Date of Patent: August 19, 1986Assignee: Nippon Petrochemicals Company LimitedInventors: Yasuo Yamazaki, Takehiko Suzuki, Masaharu Uchiyama
-
Patent number: 4600798Abstract: Aryl-diethers are provided which are produced by reacting a halogenated xylene compound, preferably 4-chloro-ortho-xylene, and an alkali metal salt of a bisphenol compound, preferably bisphenol-A. These aryl-diethers serve as precursors in a process for producing polyetherimide polymers.Type: GrantFiled: March 18, 1985Date of Patent: July 15, 1986Assignee: General Electric CompanyInventor: James A. Cella
-
Patent number: 4582925Abstract: 2,2',6,6'-Tetramethyl-4,4'-dicarboxylic acid is prepared by the oxidation of bimesityl and derivatives of the dicarboxylic acid are used in the preparation of polyesters of high molecular weight.Type: GrantFiled: May 15, 1981Date of Patent: April 15, 1986Assignee: Standard Oil Company (Indiana)Inventor: John A. Donohue
-
Patent number: 4570011Abstract: The invention is a process for the preparation of an aromatic hydrocarbon with a cyclobutene ring fused to the aromatic hydrocarbon which comprises, dissolving an ortho alkyl halomethyl aromatic hydrocarbon in an inert solvent and pyrolyzing the solution of ortho alkyl halomethyl aromatic hydrocarbon in the inert solvent under conditions such that the ortho alkyl and halomethyl substituents form a cyclobutene ring thereby forming an aromatic hydrocarbon having a fused cyclobutene ring.Type: GrantFiled: May 21, 1984Date of Patent: February 11, 1986Assignee: The Dow Chemical CompanyInventor: Ying-Hung So
-
Patent number: 4568757Abstract: A group of retinoids having "vitamin A type" activity which have the structure ##STR1## wherein R3 is a trimethylcyclohexenylethylene, tetramethyltetrahydronaphthalene or methoxytrimethylphenylethylene group;R1 and R2 which are different are selected from --OH, --OR4 and --NHR, provided one of R1 and R2 is OH; R4 is alkyl of 1 to 20 carbons; and R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbons, hydroxyalkyl of 1 to 4 carbons, alkylhydroxyalkyl of 1 to 4 carbons, phenyl, hydroxyphenyl and carboxyphenyl, and R5 is a lactone or lactam of the structure ##STR2## and X is oxygen or NR where R is as above, and the pharmaceutically acceptable salts thereof.Type: GrantFiled: January 30, 1984Date of Patent: February 4, 1986Assignee: Research Triangle InstituteInventors: Frank I. Carroll, Anita H. Lewin
-
Patent number: 4542233Abstract: Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.Type: GrantFiled: July 20, 1983Date of Patent: September 17, 1985Assignee: Biaschim S.p.A.Inventors: Oreste Piccolo, Aldo Belli, Giovanni Villa, Enrico Zen, Attilio Citterio
-
Patent number: 4449001Abstract: Oxy- and thio-aryl-phenylated aromatic biscyclopentadienones are prepared from aromatic bis-benzils and benzylketones.Type: GrantFiled: March 8, 1983Date of Patent: May 15, 1984Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Bruce A. Reinhardt, Fred E. Arnold
-
Patent number: 4433132Abstract: A class of polyesters comprising recurring units having certain bis(trifluoromethyl)biphenylene radicals is disclosed. The polyesters exhibit favorable solubility properties in certain organic solvents so as to facilitate the production of the polyesters via polycondensation methods to film- and fiber-forming molecular weights. Monomeric compounds comprising a bis(trifluoromethyl)biphenylene radical and useful for the production of the polyesters are also disclosed.Type: GrantFiled: September 2, 1982Date of Patent: February 21, 1984Assignee: Polaroid CorporationInventors: Howard G. Rogers, Russell A. Gaudiana, Richard A. Minns
-
Patent number: 4421929Abstract: Novel tetracarboxylic acids are described of the formula ##STR1## wherein Ar, R.sub.1 and R.sub.2 are named substituents, and both n's are zeros or ones.Type: GrantFiled: December 2, 1981Date of Patent: December 20, 1983Assignee: The Dow Chemical CompanyInventor: Edmund P. Woo
-
Patent number: 4410716Abstract: Novel compounds, dibenzo[a,d]cycloheptene derivatives, of the general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom or a lower alkyl group, R.sub.2 and R.sub.3 each represent a hydrogen atom or a lower alkyl group, and Z represents a group of the formula ##STR2## These novel compounds are useful as non-steroidal anti-inflammatory agents free from gastrointestinal lesions. The compounds of formula (I) can be prepared, for example, by cyclizing a compound of the general formula ##STR3## wherein R.sub.1 and R.sub.2 are as defined above, X represents a hydroxyl group or a halogen atom, one Y represents a group of the formula --CH.sub.2 COX and the other Y represents a hydrogen atom; optionally hydrolyzing the cyclized product; and optionally esterifying the product, and/or etherifying its enol group.Type: GrantFiled: September 24, 1980Date of Patent: October 18, 1983Assignee: Toa Eiyo Kagaku Kogyo Co. Ltd.Inventors: Tetsutaro Hayasaka, Kuniro Saito, Sen-ichi Narita, Takao Goto, Shin-ichi Yamada, Teruo Saito, Kazuyoshi Okutani
-
Patent number: 4400540Abstract: Oxy- and thio-aryl-phenylated aromatic biscyclopentadienones are prepared from aromatic bis-benzils and benzylketones.Type: GrantFiled: April 8, 1982Date of Patent: August 23, 1983Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Bruce A. Reinhardt, Fred E. Arnold
-
Patent number: 4390476Abstract: Phosphonium compounds of the formula(R).sub.3 P.sup..sym. --CH.sub.2 --X--CH.dbd.CH--R.sub.1 --Y.sup..crclbar.in which R is preferably alkyl having 1 to 4 C atoms, cyclohexyl or phenyl, R.sub.1 is a substituted or unsubstituted aromatic radical, especially a phenyl radical, X is phenylene, 4,4'-biphenylene or 1,4- or 2,6-naphthylene and Y.sup..crclbar. is SO.sub.3.sup..crclbar., SO.sub.2.sup..crclbar. or COO.sup..crclbar., a process for their preparation and a process for the preparation of asymetrically substituted fluorescent brightening agents of the formulaZ--CH.dbd.CH--X--CH.dbd.CH--R.sub.1 --Y.sup..crclbar. M.sup..sym.in which R.sub.1, X and Y.sup..crclbar. are as defined above, M.sup..sym. is a cation and Z is preferably a substituted or unsubstituted phenyl or 2-phenyl-triazol-4-yl radical, by reacting a bis-phosphonium compound of the formula ##STR1## in which Q.sup..crclbar. is an anion, with an aldehyde of the formula M.sup..sym. Y.sup..crclbar. --R.sub.Type: GrantFiled: November 5, 1981Date of Patent: June 28, 1983Assignee: Ciba-Geigy CorporationInventor: Michael Marky
-
Patent number: 4339595Abstract: Hexa(meta-,para-carboxyphenyl)benzene compounds. The esters are useful as plasticizers for polyvinylchloride, heat transfer agents, hydraulic fluids, and insulating oils. The acid is suitable as a cross-linking agent for polymers containing hydroxyl or amine groups.Type: GrantFiled: June 27, 1980Date of Patent: July 13, 1982Assignee: Standard Oil Company (Indiana)Inventors: Carl A. Udovich, Ellis K. Fields
-
Patent number: 4334091Abstract: This invention relates to new compositions particularly suited for producing insecticidal intermediates.Type: GrantFiled: August 14, 1978Date of Patent: June 8, 1982Assignee: Air Products and Chemicals, Inc.Inventor: Robert J. Tedeschi
-
Patent number: 4324904Abstract: The invention concerns the novel compounds dialkyl 2-(3-fluoro-4-nitrophenyl)-2-methylmalonate IIIa and dialkyl 2-(3-fluoro-4-aminophenyl)-2-methylmalonate IVa useful as intermediates in an improved process for making 2-(2-fluoro-4-biphenylyl)propionic acid, known as flurbiprofen, having the formula ##STR1## and ester thereof. It has anti-inflammatory activity which is about 240 times that of aspirin and analgesic activity which is about 180 times that of aspirin in standard laboratory tests. However, despite this high activity, the toxicity (LD.sub.50) is only 1.2 to 2.4 times greater than that of aspirin in standard laboratory tests.Also within the invention is a novel method of making the above intermediates and analogs thereof useful to prepare corresponding biaryl compounds which have pharmaceutical uses.Type: GrantFiled: December 19, 1979Date of Patent: April 13, 1982Assignee: The Upjohn CompanyInventors: Thomas A. Hylton, Jerry A. Walker
-
Patent number: 4316860Abstract: Phosphonium compounds of the formula(R).sub.3 P.sup..sym. --CH.sub.2 --X--CH.dbd.CH--R.sub.1 --Y.sup..crclbar.in which R is preferably alkyl having 1 to 4 C atoms, cyclohexyl or phenyl, R.sub.1 is a substituted or unsubstituted aromatic radical, especially a phenyl radical, X is phenylene, 4,4'-biphenylene or 1,4- or 2,6-naphthylene and Y.sup..crclbar. is SO.sub.3.sup..crclbar., SO.sub.2.sup..crclbar. or COO.sup..crclbar., a process for their preparation and a process for the preparation of asymetrically substituted fluorescent brightening agents of the formulaZ--CH.dbd.CH--X--CH.dbd.CH--R.sub.1 Y.sup..crclbar. M.sup..sym.in which R.sub.1, X and Y.sup..crclbar. are as defined above, M.sup.61 is a cation and Z is preferably a substituted or unsubstituted phenyl or 2-phenyl-triazol-4-yl radical, by reacting a bis-phosphonium compound of the formula ##STR1## in which Q.sup..crclbar. is an anion, with an aldehyde of the formula M.sup..sym. Y.sup..crclbar. --R.sub.Type: GrantFiled: May 15, 1980Date of Patent: February 23, 1982Assignee: Ciba-Geigy CorporationInventor: Michael Marky
-
Patent number: 4288588Abstract: Methyl-substituted polyphenylacyl compounds are prepared by selective oxidation of oligomers of mesitylene. These methyl-substituted polyphenylacyl compounds are useful as intermediates for polyamides and polyesters. The esters are useful as plasticizers for polyvinylchloride.Type: GrantFiled: July 13, 1978Date of Patent: September 8, 1981Assignee: Standard Oil Company (Indiana)Inventor: John A. Donohue
-
Patent number: 4249022Abstract: The present invention provides a new process for the manufacture of 1,4-disubstituted bicyclic or tricyclic compounds by reacting a 1,2-bis-cyanomethyl-benzene or 2,3-bis-cyanomethyl-naphthalene with glyoxal in the presence of a base and a solvent as well as new 1,4-disubstituted bicyclic compounds.Type: GrantFiled: July 23, 1979Date of Patent: February 3, 1981Assignee: Ciba-Geigy CorporationInventor: Leonardo Guglielmetti
-
Patent number: 4232042Abstract: The invention relates to novel compounds of general formula I: ##STR1## and salts, esters and amides thereof, in which R.sub.1 and R.sub.2 represent hydrogen, alkyl or alkenyl (1-4 C),R.sub.3 represents hydrogen, halogen, hydroxy, alkyl (1-4 C) or alkoxy (1-4 C),n has the value 0, 1 or 2 andALK is a saturated or unsaturated hydrocarbon radical with 3-12 carbon atoms, in which a straight carbon chain in between the benzene rings is present, containing 3-8 carbon atoms, andthe dotted line indicates an optional extra bond between the first and second carbon counted from the phenyl ring, in case of an extra bond the group R.sub.2 and one hydrogen attached to said second carbon being absent, having valuable hypocholesterolaemic and hypotriglyceriolaemic properties.Type: GrantFiled: October 4, 1976Date of Patent: November 4, 1980Assignee: Akzona IncorporatedInventors: Alexander C. Campbell, Colin L. Hewett, Filippus J. Zeelen
-
Patent number: 4227016Abstract: Glyoxylic acid and hydrochloric acid are reacted with an aromatic compound having at least one substituent group selected from among the alkyl, aryl, hydroxy, alkoxy and aryloxy groups. The glyoxylic acid is used in a concentration comprised between 60 and 100% and the hydrochloric acid is used in as concentrated an aqueous solution as possible, e.g. in an organic solvent medium such as acetic acid. An acid catalyst such as zinc chloride may be used. The reaction may be carried out under pressure. The products are useful in various syntheses e.g. to produce amino acids or arylacetic acids with medicinal uses.Type: GrantFiled: December 28, 1977Date of Patent: October 7, 1980Assignee: Hoechst FranceInventors: Emmanuel Herman, Helmut Diery, Michel Soreau, Yani Christidis
-
Patent number: 4179578Abstract: Stilbene derivatives having at least one further phenyl substituent in the para-position to a benzene ring in the stilbene are optical brighteners particularly suitable for incorporation on spinning masses.Type: GrantFiled: April 14, 1977Date of Patent: December 18, 1979Assignee: Sandoz Ltd.Inventors: Fritz Fleck, Hans Kittl, Salvatore Valenti
-
Patent number: 4175207Abstract: A composition of matter for use in a visual-type instrument which includes a polarizer for a light beam and an analyzer for a light beam, the chemical composition being birefringent at a first relative humidity and nonbirefringent at a second relative humidity.Type: GrantFiled: May 9, 1977Date of Patent: November 20, 1979Inventor: Stanley B. Elliott
-
Patent number: 4154922Abstract: Methyl-substituted polyphenylacyl compounds are prepared by selective oxidation of oligomers of mesitylene. These methyl-substituted polyphenylacyl compounds are useful as intermediates for polyamides and polyesters. The esters are useful as plasticizers for polyvinylchloride.Type: GrantFiled: October 15, 1975Date of Patent: May 15, 1979Assignee: Standard Oil Company (Indiana)Inventor: John A. Donohue
-
Patent number: 4154951Abstract: A compound of the formula (1) ##STR1## in which X and X' stand for an optionally functionally modified carboxy or sulfo group and wherein the naphthalene nuclei may carry further non- chromophoric substituents and a process for their preparation. These compounds are valuable optical brighteners and can be applied by the methods known in this field.Type: GrantFiled: December 16, 1974Date of Patent: May 15, 1979Assignee: Hoechst AktiengesellschaftInventor: Ulrich Pintschovius
-
Patent number: 4142036Abstract: Adamantane compounds having 2 to 4 bridgehead positions substituted with phenylacyl moieties are prepared by oxidizing poly(phenylalkyl) adamantanes. The polyacyl adamantane compounds are useful as intermediates for polyesters, polyamides and polyimides. The esters are useful as plasticizers for polyvinylchloride.Type: GrantFiled: June 1, 1976Date of Patent: February 27, 1979Assignee: Standard Oil Company (Indiana)Inventors: Allen I. Feinstein, Ellis K. Fields
-
Patent number: 4131748Abstract: p-Terphenylene-dicarboxylic acids in which aromatic groups are attached to the middle phenyl group of the terphenylene moiety. The compounds are useful as monomers in the preparation of rod-like, para-ordered aromatic heterocyclic polymers.Type: GrantFiled: June 29, 1977Date of Patent: December 26, 1978Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Fred E. Arnold, James F. Wolfe