Monocyclic Patents (Class 562/493)
  • Patent number: 10011555
    Abstract: This invention is directed to novel compounds isolated or derived from Alpiniae oxyphyllae fructus, chemically synthesized novel compounds, methods of preparing the novel compounds and uses thereof as neuroprotectants or drugs for treating neurodegenerative diseases such as Parkinson's disease.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: July 3, 2018
    Assignee: University of Macau
    Inventors: Ming Yuen Lee, Zaijun Zhang, Guohui Li
  • Patent number: 9255070
    Abstract: The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: February 9, 2016
    Assignee: WAKO PURE CHEMICAL INDUSTRIES, LTD.
    Inventors: Nobuhiro Ito, Tsuneaki Maesawa, Kazushige Muto, Kosaku Hirota, Hironao Sajiki
  • Publication number: 20150105338
    Abstract: The invention provides compositions comprising a therapeutically effective amount of a compound of general formula (I): wherein R1, R2 and R3 may be independently selected from H, OH and OMe; wherein X is C1 or C2 and wherein for C2 each carbon is linked by a single or multiple bond (preferably a double bond) and is substituted with one or more H or OH, for use as a medicament for treating or preventing the development of medical conditions characterised by inappropriate platelet aggregation. The compositions of the invention may be used to maintain heart health by reducing platelet aggregation; benefit the circulation; and/or normalize or otherwise benefit blood flow.
    Type: Application
    Filed: July 17, 2014
    Publication date: April 16, 2015
    Applicant: PROVEXIS NATURAL PRODUCTS LIMITED
    Inventor: Niamh O'Kennedy
  • Patent number: 9000209
    Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: April 7, 2015
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: George A. Kraus
  • Patent number: 8969554
    Abstract: Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides. The compounds are triazine derivatives represented by following Formula 1 or salts thereof, and the herbicides containing them: [Chem. 28] wherein in the formula, R1 represents a hydrogen atom; a C1-C12 alkyl group; a C2-C6 alkenyl group, etc., R2 represents a C1-C12 alkyl group, etc., Y and Z represent an oxygen atom or a sulfur atom, and A represents a 5- or 6-membered cyclic group which may contain a nitrogen atom, an oxygen atom, or a sulfur atom.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 3, 2015
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Atsushi Shibayama, Ryu Kajiki, Masami Kobayashi, Takashi Mitsunari, Atsushi Nagamatsu
  • Patent number: 8962014
    Abstract: The present invention relates to a transdermal therapeutic system for administering an active substance through the skin, comprising: a) a cover layer, b) a reservoir present on the cover layer, comprising a polymer matrix comprising the active substance, c) an adhesive layer present on the reservoir comprising a contact adhesive, and d) a removable layer present on the adhesive layer, the active substance being rivastigmine, a physiologically compatible salt, hydrate, solvate or derivative thereof, characterized in that the polymer matrix of the reservoir comprises neither hydroxyl groups nor carboxyl groups.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: February 24, 2015
    Assignee: Acino AG
    Inventors: Heike Prinz, Björn Schurad, Thomas Beckert, Kristina Linder
  • Publication number: 20150038731
    Abstract: The present invention relates to a process of making a compound of formula (XII) or (XIIA): wherein R1, R2, R4 and X are as defined herein.
    Type: Application
    Filed: March 15, 2012
    Publication date: February 5, 2015
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Jean-Nicolas Desrosiers, Joe Ju Gao, Jason Alan Mulder, Jinhua J. Song, Xingzhong Zeng
  • Publication number: 20150025264
    Abstract: Objects are to provide efficient methods for producing hydrogen or heavy hydrogens and for hydrogenating (protiating, deuterating or tritiating) an organic compound, and to provide an equipment and the like used therefor. A method for producing hydrogen or heavy hydrogens, containing subjecting water or heavy water to mechanochemical reaction in the presence of a catalyst metal, in which an energy density of a rotational acceleration of 75 G or more is applied to water or heavy water for 25 minutes or more, a method for producing a hydrogenated (protiated, deuterated or tritiated) organic compound, a method for hydrogenating (protiating, deuterating or tritiating) an organic compound, a method for dehalogenating an organic compound having halogen, and a ball for mechanochemical reaction are provided.
    Type: Application
    Filed: February 8, 2013
    Publication date: January 22, 2015
    Applicant: Shiono Chemical Co., Ltd.
    Inventors: Hironao Sajiki, Yasunari Monguchi, Yoshinari Sawama, Shinichi Kondo, Yasushi Sasai
  • Publication number: 20140364631
    Abstract: The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and dehydrative aromatization of dienes and dienophiles containing oxygenated substituents to form substituted benzene products. In some embodiments, the processes comprise contacting biomass-derived substrates with ethylene to form terephthalic acid and its derivatives.
    Type: Application
    Filed: May 20, 2014
    Publication date: December 11, 2014
    Inventors: MARK E. DAVIS, JOSHUA PACHECO
  • Patent number: 8846085
    Abstract: A directly tabletable ibuprofen formulation comprising a) 50-99% by weight of crystalline ibuprofen, b) 1-15% by weight of a finely divided excipient with a surface area of at least 100 m2/g, and c) 0-40% by weight of further excipients, with the proviso that the total amount of components a) to c) corresponds to 100% by weight, where at least 50% of the surface of the ibuprofen crystals are covered with the finely divided excipient.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: September 30, 2014
    Assignee: BASF SE
    Inventors: Kathrin Meyer-Boehm, Karl Kolter, Anisul Quadir
  • Publication number: 20140288324
    Abstract: A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.
    Type: Application
    Filed: June 21, 2012
    Publication date: September 25, 2014
    Inventor: George A. Kraus
  • Patent number: 8835409
    Abstract: 3-Alkenyl-6-halo-4-aminopicolinic acids and their derivatives are potent herbicides demonstrating a broad spectrum of weed control.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: September 16, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Joseph D. Eckelbarger, Jeffrey B. Epp, Paul R. Schmitzer, Thomas L. Siddall
  • Publication number: 20140235722
    Abstract: The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 21, 2014
    Applicant: NOVARTIS AG
    Inventors: Guido Jordine, Michael Mutz
  • Patent number: 8802892
    Abstract: The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R?]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: August 12, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Patent number: 8759571
    Abstract: A process for oxidizing an alkyl-aromatic compound is described. The process includes oxidizing the alkyl-aromatic compound to produce a first oxidation product; contacting at least a portion of the first oxidation product, a solvent comprising an ionic liquid, a bromine source, a catalyst, and an oxidizing agent to produce a second oxidation product comprising at least one of an aromatic alcohol, an aromatic aldehyde, an aromatic ketone, and an aromatic carboxylic acid.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: June 24, 2014
    Assignee: UOP LLC
    Inventors: Alakananda Bhattacharyya, Joel T. Walenga
  • Publication number: 20140163257
    Abstract: An object of the present invention is to provide a method for reducing a halogenobenzoic acid ester, in which dehalogenation is inhibited, by using a readily available catalyst. The method comprises reducing an ester with hydrogen gas by using an aromatic hydrocarbon as a solvent in the presence of a ruthenium complex represented by the following general formula (1): RuXY(CO)(L)??(1) where X and Y represent monovalent anionic ligands, and L represents a tridentate aminodiphosphine ligand represented by the following general formula (2): where RZ1 represents an alkyl group having 1 to 4 carbon atoms, each RZ2 represents an alkyl group having 1 to 4 carbon atoms or a halogen atom, any adjacent two RZ2s may form a ring, Hal represents a halogen atom, and n represents 0 to 4.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 12, 2014
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Kiyoto HORI, Osamu OGATA, Wataru KURIYAMA
  • Patent number: 8741956
    Abstract: The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: June 3, 2014
    Assignee: Nuvo Research Inc.
    Inventors: Jagat Singh, Joseph Zev Shainhouse, Bradley S. Galer, Robert Dominic King-Smith, Lisa Marie Grierson, Maria Burian, Jonathan Wilkin, Edward Kisak, John M. Newsam
  • Patent number: 8692018
    Abstract: The present invention relates to a preparation method of carboxylic acids with optical activity, particularly, publishes that very useful chiral carboxylic acids can be obtained by the asymmetric catalytic hydrogenation of tri-substituted ?,?-unsaturated carboxylic acids, with the complexes of the chiral phosphor nitrogen ligands and iridium used as the catalysts which show high activity and enantioselectivity (up to 99.8% ee), thus provides a more efficient method with higher enantioselectivity for asymmetric catalytic hydrogenation of chiral carboxylic acid-like compounds, and has important application value to asymmetric hydrogenation of chiral carboxylic acids.
    Type: Grant
    Filed: January 20, 2009
    Date of Patent: April 8, 2014
    Assignee: Zheijiang Jiuzhou Pharmaceutical Co., Ltd.
    Inventors: Qilin Zhou, Shen Li, Shoufei Zhu, Canming Zhang, Lixin Wang
  • Publication number: 20140087978
    Abstract: A method of converting an inactive biocide into an active biocide comprises: contacting the inactive biocide with an activating agent, wherein the activating agent is capable of chemically reacting with the inactive biocide; and causing or allowing a chemical reaction to take place between the inactive biocide and the activating agent, wherein the chemical reaction produces the active biocide. The methods can also include deactivating the active biocide via a chemical reaction between the active biocide and a deactivating agent.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 27, 2014
    Applicant: HALLIBURTON ENERGY SERVICES, INC
    Inventor: Jay P. DEVILLE
  • Patent number: 8680146
    Abstract: The present invention relates to salts, polymorphs and hydrates of 2-Amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diol, and to the use thereof, in particular in the treatment or prevention of various autoimmune conditions.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: March 25, 2014
    Assignee: Novartis AG
    Inventors: Guido Jordine, Michael Mutz
  • Patent number: 8669210
    Abstract: This invention relates to a high-strength, aqueous herbicidal concentrate containing the clopyralid dimethylamine salt. The formulation is stable to storage and exhibits lower viscosity than other clopyralid amine salt formulations.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: March 11, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventor: Robert M. Buttimor
  • Patent number: 8669209
    Abstract: Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: March 11, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Franklin N. Keeney, Neil A. Foster, Martin C. Logan, Maria G. Perry
  • Publication number: 20130296432
    Abstract: Disclosed herein are benzoic acid-enriched plant extracts and uses thereof Specifically, benzoic acid-enriched plant extracts free of toxic substances and organic solvents and use thereof are disclosed. More specifically, a benzoic acid-enriched lingonberry extract free of toxic substances and organic solvents and its use as a preservative is provided.
    Type: Application
    Filed: March 13, 2013
    Publication date: November 7, 2013
    Applicant: EPC (Beijing) Natural Products Co., Ltd.
    Inventors: Jingang Shi, Wenchao Lu, Feng Sun
  • Publication number: 20130296429
    Abstract: Disclosed herein are forms of L-ornithine phenyl acetate and methods of making the same. A crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
    Type: Application
    Filed: July 8, 2013
    Publication date: November 7, 2013
    Inventors: Keith Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
  • Publication number: 20130281664
    Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 24, 2013
    Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
  • Patent number: 8552050
    Abstract: The invention described herein features methods, compositions, and kits for the use of activators of PKM2 for the treatment, prevention, or amelioration of diseases related to PKM2 function, including, e.g., cancer, diabetes, atherosclerosis, restenosis, obesity, autoimmune disorders, and proliferative disorders.
    Type: Grant
    Filed: August 18, 2008
    Date of Patent: October 8, 2013
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: Lewis C. Cantley, Matthew G. Vander Heiden, Heather R. Christofk
  • Patent number: 8546450
    Abstract: The field involves compositions useful for pain relief, including diclofenac solution and gel formulations, in particular methods of use thereof, articles of manufacture and kits that provide novel preclinical, clinical and other information to users.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: October 1, 2013
    Assignee: Nuvo Research Inc.
    Inventors: Jagat Singh, Joseph Zev Shainhouse, Bradley S. Galer, Robert Dominic King-Smith, Lisa Marie Grierson, Maria Burian, Jonathan Wilkin, Edward T. Kisak, John M. Newsam
  • Publication number: 20130211135
    Abstract: Disclosed herein are processes for making L-ornithine phenyl acetate. The process may include, for example, inter-mixing a halide salt of L-ornithine with silver phenyl acetate. The process may also include forming a phenyl acetate salt in situ. The present application also relates to various compositions obtained from these processes, including crystalline forms.
    Type: Application
    Filed: October 5, 2011
    Publication date: August 15, 2013
    Applicant: Ocera Therapeutics, Inc.
    Inventors: Keith H. Anderson, Jim Behling, Christine Henderson Dougan, Stephen William Watt, Peter Manini, Attilia Figini
  • Patent number: 8481596
    Abstract: The present invention relates to a novel crystalline form L of (±)-desvenlafaxine benzoate and process for the preparing of the same. Further, the present invention also relates to pharmaceutical composition of novel crystalline form L of desvenlafaxine benzoate and one or more pharmaceutically acceptable excipient.
    Type: Grant
    Filed: September 21, 2011
    Date of Patent: July 9, 2013
    Assignee: Lupin Limited
    Inventors: Gurvinder Pal Singh, Dabeer Rauf Karnalkar, Hemraj Mahadeorao Lande, Girij Pal Singh
  • Publication number: 20130172612
    Abstract: A process for oxidizing an alkyl-aromatic compound is described. The process includes oxidizing the alkyl-aromatic compound to produce a first oxidation product; contacting at least a portion of the first oxidation product, a solvent comprising an ionic liquid, a bromine source, a catalyst, and an oxidizing agent to produce a second oxidation product comprising at least one of an aromatic alcohol, an aromatic aldehyde, an aromatic ketone, and an aromatic carboxylic acid.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 4, 2013
    Applicant: UOP LLC
    Inventors: Alakananda Bhattacharyya, Joel T. Walenga
  • Publication number: 20130161228
    Abstract: A plastic container containing a pharmaceutical composition comprising benzoic acid or a derivative or a pharmaceutically acceptable salt thereof and a COX-inhibitor of the oxicam-type or a pharmaceutical acceptable salt thereof, wherein the container material selected from one or more members of the group consisting of a homopolymer of polypropylene (PP), a copolymer of polypropylene (PP), a homopolymer of polyethylene terephthalate (PET) and a copolymer of polyethylene terephthalate (PET), and optionally one or more non-polymeric components.
    Type: Application
    Filed: March 13, 2013
    Publication date: June 27, 2013
    Applicant: BOEHRINGER INGELHEIM VETMEDICA GMBH
    Inventors: Martin A. Folger, Samuel C. Crowley, Amy J. Wilson
  • Publication number: 20130144084
    Abstract: The present invention relates to a method for preparing carboxylic acids comprising the step of contacting an aromatic hydrocarbon comprising at least one group including an ? C-atom that is oxidizable to a carboxylic group in liquid phase with an oxygen containing gas in the presence of a heterogeneous catalyst with perovskite structure ABO3 with A being selected from at least one element of groups 1 to 3 of the Periodic Table, lanthanides or actinides, and B being selected from at least one element of the groups 4 to 15 of the periodic table or an oxygen-defective derivative of that catalyst having the formula ABO3?? with 0<?<1.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 6, 2013
    Applicant: KING SAUD UNIVERSITY
    Inventors: Saeed Mohammed AI-Zahrani, Horacio Falcon Richeni, Ainara Aguadero Garin, Jose Antonio Alonso Alonso, Jose Miguel Campos Martin, Jose Luis Garcia Fierro
  • Patent number: 8440711
    Abstract: The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PMN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the treatment of damages caused by ischemia and reperfusion.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: May 14, 2013
    Assignee: Dompe Pha.r.ma S.p.A.
    Inventors: Marcello Allegretti, Andrea Aramini, Maria Candida Cesta
  • Publication number: 20130115654
    Abstract: A method for utilizing agricultural biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from agricultural biomass for producing derivative products while minimizing waste products.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: Thesis Chemistry, LLC
    Inventors: John R. Peterson, Christopher M. Yost, Jian Wu
  • Publication number: 20130115653
    Abstract: A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: Thesis Chemistry, LLC
    Inventors: John R. Peterson, Christopher M. Yost, Jian Wu
  • Publication number: 20130096326
    Abstract: A method of purification and production of value-added, biobased chemicals and derivative products from crude bioglycerin is described herein. The present method provides methods for desalinating, decolorizing, and concentrating bioglycerin for the production of biobased chemicals or purified bioglycerin.
    Type: Application
    Filed: October 12, 2011
    Publication date: April 18, 2013
    Applicant: THESIS CHEMISTRY, LLC
    Inventors: John R. Peterson, Christopher M. Yost
  • Publication number: 20130096209
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Application
    Filed: April 15, 2011
    Publication date: April 18, 2013
    Applicants: Kraft Foods Global Brands LLC, Chromocell Corporation
    Inventors: David Hayashi, William P. Jones, Jane V. Leland, Peter H. Brown, Joseph Gunnet, Daniel Lavery, Louise Slade, Kambiz Shekdar, Jessica Langer
  • Patent number: 8410309
    Abstract: Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: July 18, 2006
    Date of Patent: April 2, 2013
    Assignee: Emisphere Technologies, Inc.
    Inventors: Andrea Leone-Bay, Kelly Kraft, Destardi Moye-Sherman, David Gschneidner, Maria Aurora P. Boyd, Puchun Liu, Pingwah Tang, Jun Liao, John Smart, John J. Freeman, Jr.
  • Patent number: 8394986
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: March 12, 2013
    Assignee: AstraZeneca AB
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • Publication number: 20130055632
    Abstract: The invention relates to a method for producing coal, asphalt, liquid hydrocarbon, organic acids, methane gas and/or hydrogen from a waste material comprising: a) providing a waste material; b) subjecting the waste material to irradiation with low frequency macro waves, with a wavelength of between 700 nm and 1 mm, whereby the temperature is between 2050 C and 9000 C and the pressure is between 1.0 bar and 19.0 bar, thereby producing coal; c) optionally subjecting the residual materials in gaseous state from step b) to a physicochemical reaction in the presence of a solid metal identified as DPP B102, whereby the temperature is between 1800 C and 5000 C and the pressure is between 0.98 bar and 5.5 bar, thereby producing asphalt; d) optionally subjecting the residual materials in gaseous state from step b) or c) to a physicochemical reaction and/or condensation, whereby the temperature is between 1500 C and 7500 C and the pressure is between 0.
    Type: Application
    Filed: February 21, 2011
    Publication date: March 7, 2013
    Inventors: Dieter Peter Petry, Aldo Mario Higinio Acosta Ayala, Andres Anastacio Barrios Maciel, Leon Isaac Vera Vera
  • Patent number: 8362234
    Abstract: The present invention relates to a compound according to the formula: wherein R1, R2, R3, R4, R5, R6, R7, R8, Y, Z, n, s, and t are as defined herein. These compounds are useful for methods of solid phase synthesis.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: January 29, 2013
    Inventors: Paul J. Hatala, Markus Kurz
  • Patent number: 8354555
    Abstract: This invention provides a method for increasing the activity of catalysts. The method requires the introduction of the catalyst into nano-structured surfaces. The catalysts are introduced as functional groups in molecules forming a monolayer on a surface. A mixed monolayer of catalyst and inert molecules generates ordered domains of molecules on the surface. The catalyst is confined in regions of 0.5 nm to 3 nm in size and is surrounded by an inert material. The presence of such ordered domains that commensurate in size with the reactants, enhance the performance of the catalyst and increase the rate of the reaction.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: January 15, 2013
    Assignee: Massachusetts Institute of Technology
    Inventors: Francesco Stellacci, Benjamin Wunsch
  • Publication number: 20130012699
    Abstract: The present invention relates to a carbon dioxide absorbent, an ionic liquid obtained by reacting amide and an organic acid and a method of using the same. The amidium-based ionic liquid of the present invention has excellent CO2 absorption capability, which is hardly reduced even with repeated use, is easy to synthesize and has low manufacturing cost thus being useful as a CO2 absorbent.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicants: Kia Motors Corporation, Hyundai Motor Company
    Inventors: Seok Jin Choi, Jelliarko Palgunadi, Je Eun Kang, Hoon Sik Kim, Sung Yeup Chung
  • Publication number: 20120330056
    Abstract: A method for preparing aromatic carboxylic acid derivatives by nucleophilic aromatic substitution, involves reacting an aromatic carboxylic acid derivative supporting only one carboxyl function, or one of the salts thereof, the carboxylic acid derivative supporting, orthogonally to the carboxyl function, a leaving group which is a fluorine or chlorine atom or an alkoxy group, chiral or otherwise and, in the latter case, preferably a methoxy group; the carboxylic acid derivative being substituted by at least one electro-attractive group other than the leaving group, preferably by a fluorine atom, with a MNu reagent, wherein M is a metal and Nu an optionally chiral nucleophile, the nucleophilic aromatic substitution reaction being carried out without a catalyst and without a step of protecting/unprotecting the acid function of the initial compound, the method being selective in that the reaction leads to the formation of ketone derivatives in a very minority fashion during the reaction.
    Type: Application
    Filed: February 18, 2011
    Publication date: December 27, 2012
    Applicants: UNIVERSITE DU MAINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jacques Mortier, Anne-Sophie Castanet, Arnaud Nourry, Mickael Belaud-Rotureau
  • Publication number: 20120316238
    Abstract: The present invention relates to a novel crystalline form L of (±)-desvenlafaxine benzoate and process for the preparing of the same. Further, the present invention also relates to pharmaceutical composition of novel crystalline form L of desvenlafaxine benzoate and one or more pharmaceutically acceptable excipient.
    Type: Application
    Filed: September 21, 2011
    Publication date: December 13, 2012
    Applicant: Lupin Limited
    Inventors: Gurvinder Pal SINGH, Dabeer Rauf Karnalkar, Hemraj Mahadeorao Lande, Girij Pal Singh
  • Patent number: 8318975
    Abstract: The present invention provides a method for producing a phenylalanine derivative(s) having a quinazolinedione ring of formula (5), including steps comprising of reacting an acylphenylalanine derivative(s) of formula (1) with a carbonyl group-introducing reagent(s) and a derivative(s) of anthranilic acid to form an asymmetric urea intermediate(s); making the asymmetric urea intermediate(s) into a quinazolinedione compound(s) of formula (4) in the presence of a base(s); and N-alkylating quinazolinedione ring amide of the obtained quinazolinedione compounds with N-alkylation agents. This production method is an industrially applicable method for producing phenylalanine derivatives having a quinazolinedione skeleton, which are compounds highly useful as drugs having ? 4 integrin inhibiting activity.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: November 27, 2012
    Assignee: Ajinomoto Co., Inc.
    Inventors: Noriyasu Kataoka, Akinori Tatara, Masanobu Yatagai, Junko Yamanaka
  • Patent number: 8314268
    Abstract: 1-Phenylalkanecarboxylic acid derivatives, the processes for the preparation thereof and the use thereof in the treatment and/or prevention of neurodegenerative diseases such as Alzheimer's disease.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: November 20, 2012
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Luca Raveglia, Ilaria Peretto, Stefano Radaelli, Bruno Pietro Imbimbo, Andrea Rizzi, Gino Villetti
  • Patent number: 8314045
    Abstract: A porous solid acid catalyst having high concentration of acidic sites and a large surface area includes a porous silica support and a sulfonated carbon layer disposed within the pores of the silica support. The catalyst, in certain embodiments, has a concentration of —SO3H groups of at least about 0.5 mmol/g and a predominant pore size of at least about 300 ?. The catalyst is used to catalyze a variety of acid-catalyzed reactions, including but not limited to alkylation, acylation, etherification, olefin hydration and alcohol dehydration, dimerization of olefin and bicyclic compounds, esterification and transesterification. For example, the catalyst can be used to catalyze esterification of free fatty acids (FFAs) and, in certain embodiments, to catalyze transesterification of triglycerides in fats and oils.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: November 20, 2012
    Assignee: Entreprises Sinoncelli S.A.R.L.
    Inventors: Jacques Sinoncelli, Sergey V. Gurevich
  • Publication number: 20120264660
    Abstract: A traceable treatment composition for treating a subterranean formation having multiple zones penetrated by a well bore comprising a homogenous blend of a tracking composition and a resin composition. The tracking composition comprises a substantially non-radioactive tracking material selected from the group consisting of a metal salt. The metal portion of the metal salt may be selected from the group consisting of gold, silver, lithium, molybdenum, and vanadium.
    Type: Application
    Filed: June 27, 2012
    Publication date: October 18, 2012
    Applicant: Halliburton Energy Seervices, Inc.
    Inventors: Philip D. Nguyen, Jimmie D. Weaver, Johnny A. Barton
  • Publication number: 20120245132
    Abstract: The present invention relates to the use of low content of benzoic acid and/or sodium salt thereof in combination with one or more organic acid preservatives as active ingredients in the manufacture of a vaginal composition, wherein the composition has weak inhibition effect on normal vaginal lactobacilli while has strong inhibition effect on vaginal fungi and/or pathogenic vaginal lactobacilli, the organic acid preservatives are selected from the group consisting of dehydroacetic acid and/or sodium salt thereof, propionic acid and/or a salt thereof, sorbic acid and/or a salt thereof. The composition of the present invention is particularly useful in inhibiting vaginal fungi, and/or inhibiting pathogenic vaginal lactobacilli, and/or promoting normal vaginal lactobacilli, and/or maintaining normal vaginal acidity, and/or modulating vaginal microecosystem, and/or modulating vaginal microbials, and/or selectively decontaminating vagina.
    Type: Application
    Filed: October 8, 2010
    Publication date: September 27, 2012
    Inventors: Zhongming Zeng, Ruyun Zhou