Citric Acid Per Se Or Salt Thereof Patents (Class 562/584)
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Patent number: 6875891Abstract: This invention relates to a novel process for preparing highly water soluble alkaline earth metal and alkali metal double salts of hydroxycitric acid. These salts are practically odourless and has negligible taste and are therefor useful as nutraceuticals. Aqueous extract of the fruits belonging to Garcinia species are treated to precipitate its alkaline earth metal salts such as the calcium salt. This sparingly soluble product is dissolved in alkali hydroxide and the pH of the solution is adjusted by adding purified extract of the fruit rind. Ca/Na or Ca/K double salts are particularly useful.Type: GrantFiled: March 19, 2004Date of Patent: April 5, 2005Assignee: Laila ImpexInventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Sridhar Pratha
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Publication number: 20040229953Abstract: This invention relates to a novel process for preparing highly water soluble alkaline earth metal and alkali metal double salts of hydroxycitric acid. These salts are practically odourless and has negligible taste and are therefor useful as nutraceuticals. Aqueous extract of the fruits belonging to Garcinia species are treated to precipitate its alkaline earth metal salts such as the calcium salt. This sparingly soluble product is dissolved in alkali hydroxide and the pH of the solution is adjusted by adding purified extract of the fruit rind. Ca/Na or Ca/K double salts are particularly useful.Type: ApplicationFiled: March 19, 2004Publication date: November 18, 2004Inventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Sridhar Pratha
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Patent number: 6777213Abstract: A process for recovering carboxylic acids from an aqueous mixture such as a fermentation broth using a solvent containing at least one olefin without the need for first removing the spent microorganism cells is provided. A co-solvent which increases the partition coefficient of the solvent relative to the carboxylic acid may optionally be included. The resulting carboxylic acid is hydrogenated to produce a saturated carboxylic acid.Type: GrantFiled: August 13, 2003Date of Patent: August 17, 2004Assignee: Cognis CorporationInventor: Michael D. Staley
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Patent number: 6770782Abstract: The present invention provides a new process for the isolation of hydroxy citric acid in the form of a potassium salt from Garcinia fruit. The present invention also provides compositions containing the potassium hydroxy citrate for use as appetite suppressants.Type: GrantFiled: May 22, 1998Date of Patent: August 3, 2004Assignee: Sabinsa CorporationInventors: Muhammed Majeed, Vladimir Badmaev, Ramaswamy Rajendran
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Patent number: 6670505Abstract: A process for recovering a desired organic acid from a solution includes the steps of: providing an aqueous solution including at least one desired organic acid or its acid anion; adjusting the proton concentration in the aqueous solution to a desired level, with the desired proton concentration being selected, at least in part, by the amount of available protons needed to associate with the acid anions of the desired organic acid(s) to be recovered and/or acid anions that are weaker than the desired organic acids; and recovering at least a portion of the at least one desired organic acid from the aqueous phase. The desired proton concentration can be based on the amount of available protons being greater than, less than or substantially equal, to the amount of protons needed to associate with the anion of the desired organic acid(s) and acid anions that are weaker than the desired organic acid(s).Type: GrantFiled: March 7, 2000Date of Patent: December 30, 2003Assignee: Eastman Chemical CompanyInventors: Nick Allen Collins, Mark Robert Shelton, George William Tindall, Steven Thomas Perri, Ruairi Seosamh O'Meadhra, Chester Wayne Sink, Bhaskar Krishna Arumugam, John Clark Hubbs
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Patent number: 6652820Abstract: A method of making a cesium salt is described and involves reacting a cesium sulfate containing solution with lime to form 1) a solution containing at least cesium hydroxide and 2) a residue comprising calcium sulfate. The method further involves removing the residue from the solution and converting the cesium hydroxide that is present in the solution to at least one type of cesium salt. The present invention further relates to uses of the cesium salt as well as methods of making cesium hydroxide using lime. Also, methods of making alkali metal salts and alkali metal hydroxides are also described.Type: GrantFiled: April 2, 2001Date of Patent: November 25, 2003Assignee: Cabot CorporationInventor: Bart F. Bakke
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Publication number: 20030207942Abstract: Disclosed is a hydroxycitric acid salt composition comprising calcium and potassium salts of hydroxycitric acid, preferably in a defined proportion which yields a very pure, stabilized preparation that is substantially tasteless for optimal use in a variety of foods items. The HCA salts are prepared by a process that includes treating an aqueous extract of Garcinia cambogia or Garcinia indica fruit with a liquid quaternizing agent such as a trialkylamine in which the alkyl groups are octyl, caprylyl, isooctyl, lauryl or decyl.Type: ApplicationFiled: April 29, 2003Publication date: November 6, 2003Applicant: Unibar CorporationInventors: Sunil Bhaskaran, Sevanti Mehta
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Patent number: 6569075Abstract: Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed.Type: GrantFiled: October 1, 2001Date of Patent: May 27, 2003Assignee: Brigham and Women's HospitalInventor: Charles N. Serhan
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Patent number: 6555078Abstract: The present invention provides an inexpensive process for the preparation of lithium salts of formula LiX having a desired or required level of purity using lithium chloride and lithium sulfate. In the process of the invention, a lithium salt selected from lithium chloride, lithium sulfate, and combinations thereof is reacted with NaX or KX in a aqueous, semiaqueous, or organic solution and the precipitated salts are removed to obtain the LiX solution of desired purity. Preferably, a semiaqueous solution containing water and an organic solvent is used at some point in the reaction. The process of the invention eliminates the use of highly acidic materials and thus reduces the cost of raw materials and the need for specialized equipment.Type: GrantFiled: September 16, 1997Date of Patent: April 29, 2003Assignee: FMC CorporationInventor: Vijay Chandrakant Mehta
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Patent number: 6433163Abstract: The present invention provides a novel process for the removal and recovery of penicillin and organic acids from process streams and waste waters. The process of the present invention utilizes a combination of a supported liquid membrane (SLM) and a strip dispersion to improve extraction of the penicillin and organic acids while increasing membrane stability and reducing processing costs.Type: GrantFiled: April 3, 2000Date of Patent: August 13, 2002Assignee: Commodore Separation Technoligies, Inc.Inventor: W. S. Winston Ho
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Patent number: 6395179Abstract: Described are preferred processes separating desired chemical products from impurities in solution utilizing thermally-managed chromatography over solid adsorbents. The preferred processes involve chromatographic principles which are assisted by varying the temperature of operation in separation and elution phases. Also described are processes for treating aqueous acids to dewater and recover the acids in an organic solvent such as an alcohol.Type: GrantFiled: August 25, 2000Date of Patent: May 28, 2002Assignee: Reilly Industries, Inc.Inventors: Martin Grendze, Frank Verhoff
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Patent number: 6395061Abstract: A process for leaching an ore that contains nickel and magnesium includes mixing a microorganism that is capable of producing an organic acid, a nutrient, and an ore that contains nickel and magnesium for a period of time to dissolve the nickel and form a solution containing a nickel salt and a magnesium salt, separating the nickel from the magnesium in the salt solution.Type: GrantFiled: December 27, 2000Date of Patent: May 28, 2002Assignee: BHP Minerals International Inc.Inventors: Willem P. C. Duyvesteyn, Houyuan Liu
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Patent number: 6395296Abstract: The present invention is directed to a new soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of general formula I: where X is IA group metal: Li or Na or K or Rb or Cs or Fr where Y is IIA group metal: Be or Mg or Ca or Sr or Ba or Ra where the concentration of X in the salt varies from 1.5-51.0%, the concentration of Y in the salts varies from 2.0-50.9%, the concentration of HCA in the salt varies from 31.0-93.0% depending on the nature of X and Y. This invention more particularly relates to new soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of general formula II.Type: GrantFiled: August 11, 2000Date of Patent: May 28, 2002Inventors: Karanam Balasubramanyam, Bhaskaran Chandrasekhar, Candadai Seshadri Ramadoss, Pillarisetti Venkata Subba Rao
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Patent number: 6376223Abstract: Polycarboxylic acids are purified by contacting a crude polycarboxylic acid with a solvent to produce a substantially pure polycarboxylic acid. The solvent is chosen so that the impurities are soluble in the solvent and the polycarboxylic acid is insoluble in the solvent.Type: GrantFiled: August 3, 2000Date of Patent: April 23, 2002Assignee: Cognis CorporationInventor: Michael D. Staley
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Patent number: 6211407Abstract: A dicreatine citrate or tricreatine citrate, comprising two and three creatine cations per citrate anion, respectively. The dicreatine citrate has a melting point of about 146° F., and the tricreatine citrate has a melting point of about 154° F.Type: GrantFiled: May 3, 2000Date of Patent: April 3, 2001Assignee: Pfanstiehl Laboratories, Inc.Inventor: James Kenneth Thomson
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Patent number: 6160172Abstract: The present invention is directed to a new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula I:where X is IA group metal: Li or Na or K or Rb or Cs or Frwhere Y is IIA group metal: Be or Mg or Ca or Sr or Ba or Rawhere the concentration of X in the salt varies from 1.5-51.0%,the concentration of Y in the salts varies from 2.0-50.9%,the concentration of HCA in the salt varies from 31.0-93.0% depending on the nature of X and Y.This invention more particularly relates to new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula II.Type: GrantFiled: April 14, 1998Date of Patent: December 12, 2000Assignee: Vittal Mallya Scientific Research FoundationInventors: Karanam Balasubramanyam, Bhaskaran Chandrasekhar, Candadai Seshadri Ramadoss, Pillarisetti Venkata Subba Rao
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Patent number: 6146534Abstract: Described are preferred processes separating desired chemical products from impurities in solution utilizing thermally-managed chromatography over solid adsorbents. The preferred processes involve chromatographic principles which are assisted by varying the temperature of operation in separation and elution phases. Also described are processes for treating aqueous acids to dewater and recover the acids in an organic solvent such as an alcohol.Type: GrantFiled: August 19, 1996Date of Patent: November 14, 2000Assignee: Reilly Industries, Inc.Inventors: Martin Grendze, Frank Verhoff
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Patent number: 6114577Abstract: Described are preferred processes and apparatuses for thermally desorbing desired chemical products from resins to which they are adsorbed. The processes and apparatuses provide highly efficient use of applied heat throughout resin preheat, desorption and cooling phases.Type: GrantFiled: October 23, 1996Date of Patent: September 5, 2000Assignee: Reilly Industries, Inc.Inventors: Francis H. Verhoff, Martin Grendze
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Patent number: 6022992Abstract: A cation exchange membrane mediated acid-salt metathetic process. An aqueous salt solution is placed into a first compartment on one side of the membrane together with an organic amine extractant of limited water miscibility, and an aqueous acid solution is placed into a second compartment on the other side of the membrane. Product acid forms in the first compartment and collects in the organic amine extractant from where it is recovered. The process is particularly suitable for the recovery of a carboxylic acid from its salt.Type: GrantFiled: May 28, 1998Date of Patent: February 8, 2000Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Aharon Eyal
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Patent number: 5965028Abstract: A process for treating a liquid comprising subjecting a liquid containing, in solution, citric acid as well as a less desirable component having a similar molecular weight to citric acid, to nanofiltration in a filtration step. From the filtration step, a permeate in which the ratio of the concentration of the citric acid to that of the less desirable component is greater than the ratio of the concentration of the citric acid to that of the less desirable component in the solution, is obtained.Type: GrantFiled: March 4, 1997Date of Patent: October 12, 1999Assignee: Reilly Industries, Inc.Inventors: Francis H. Verhoff, Sanet Grond, Fadl Hendricks, Lakshminarayanan Pattabiraman Raman
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Patent number: 5928911Abstract: Process for the manufacture of citric acid, characterized in that at least part of the carbohydrate raw material consists of a wheat starch B hydrolysate.Type: GrantFiled: May 21, 1996Date of Patent: July 27, 1999Assignee: Roquette FreresInventor: Marie-Helene Saniez
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Patent number: 5929276Abstract: The invention relates to a process for producing anhydrous trisodium citrate the structure of which is unchanged as compared to a crystalline hydrate form, the anhydrous trisodium citrate, as well as its use as a carrier for inorganic and/or organic substances, in particular after being impregnated with liquids.Type: GrantFiled: April 6, 1998Date of Patent: July 27, 1999Inventors: August Ernst Kirkovits, Josef Gass
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Patent number: 5911992Abstract: A method of controlling weight in mammals by orally administering to the mammal an amount of a pharmaceutical composition containing Hypericum perforatum or active components thereof effective to control the weight of the mammal is described. The pharmaceutical composition also preferably further contains at least one thermogenic agent and at least one agent inhibiting lipogenesis. The at least one thermogenic agent includes one or more of N-acetyl-L-carnitine, cayenne extract, inositol hexanicotinate, niacin or salicin. The at least one agent inhibiting lipogenesis may be hydroxy citric acid. When the pharmaceutical composition includes Hypericum perforatum, at least one thermogenic agent and at least one agent inhibiting lipogenesis, the composition acts to control the weight of the mammal by simultaneously suppressing appetite, inducing thermogenesis and inhibiting lipogenesis.Type: GrantFiled: June 12, 1997Date of Patent: June 15, 1999Assignee: A. Glenn BraswellInventors: A. Glenn Braswell, Aftab J. Ahmed
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Patent number: 5831123Abstract: A process for producing a granulated material from a powder mixture containing at least two components, one of which is in crystal or crystalline form and at least one contains water of crystallization and/or is reactive, granulation is carried out in an inclined drum. Powder is fed in at one end and granulate removed at the other, after being transported inside the drum for a desired period while the drum is rocked in a way which largely eliminates shear forces. A quantity of liquid at least approximately equal to the quantity of water of crystallization present and sufficient for the formation of a superficially active solution adhesive is released inside the drum, where appropriate by partial reaction of the reactive component(s), after which the powder mixture components are granulated by surface adhesion.Type: GrantFiled: June 4, 1996Date of Patent: November 3, 1998Assignee: Gerhard GergelyInventors: Gerhard Gergely, Wolfram Tritthart
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Patent number: 5780276Abstract: Recovery of carboxylic acid from an amine-based, water-immiscible organic extractant solution thereof that contains an enhancer, by extraction of the acid into an aqueous phase. A low molecular, at least partly water-miscible organic compound being a C.sub.2 -C.sub.5 alkanol, an acetate of a C.sub.1 -C.sub.3 alkanol and acetone is used as enhancer. In operation, the enhancer is recovered and recycled. The process is applicable, among others, to the recovery of carboxylic acid from a fermentation broth.Type: GrantFiled: November 25, 1996Date of Patent: July 14, 1998Assignee: Innova S.A.Inventor: Avraham Matityahu Baniel
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Patent number: 5762951Abstract: The present invention relates to an acidic effervescent component for direct tableting of effervescent tablets and a process for its preparation.Type: GrantFiled: July 26, 1993Date of Patent: June 9, 1998Assignee: Bayer AktiengesellschaftInventors: Joachim Maasz, Christian Fritsch, Werner Grawingholt, Bernhard Streuff, Georg Frank
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Patent number: 5693359Abstract: A dry food acidulent composition, reminiscent of vinegar when hydrated, comprises a dry food acid, a buffering salt and a fully dissociatable salt. The dry food acid preferably comprises adipic, citric, fumaric, malic acid or a mixture. The buffering salt is preferably a sodium or potassium salt of a food-grade acid such as sodium citrate, potassium citrate, disodium phosphate, dipostassium phosphate, and mixtures. The fully dissociatable salt is preferably sodium chloride or potassium chloride. The preferred weight ratio of the buffering salt to the acid is within the range of from about 0.1:1 to about 0.3:1, that of the fully dissociatable salt to the acid is within the range of from about 1:1 to about 6:1, and that of the fully dissociatable salt to the buffering salt is within the range of from about 10:1 to about 30:1. These compositions are admixed with other dry ingredients to prepare dry sauce and dressing mixes.Type: GrantFiled: December 19, 1995Date of Patent: December 2, 1997Inventor: Robert W. Wood
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Patent number: 5665307Abstract: There is provided a disinfecting material effective against Hepatitis B, including citric acid and optionally malic acid and/or lactic acid. This viricidal material is not only environmentally acceptable and has low human toxicity, but has high effectiveness at relatively low temperatures for comparatively short times. This disinfecting material containing aqueous citric acid is particularly effective in critical clinical areas.Type: GrantFiled: June 7, 1995Date of Patent: September 9, 1997Assignee: Fresenius AGInventors: Ulrich Kirschner, Thomas Pohl
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Patent number: 5412126Abstract: Carboxylic acids are sorbed from aqueous feedstocks into an organic liquid phase or onto a solid adsorbent. The acids are freed from the sorbent phase by treating it with aqueous alkylamine thus forming an alkylammonium carboxylate which is dewatered and decomposed to the desired carboxylic acid and the alkylamine.Type: GrantFiled: March 12, 1993Date of Patent: May 2, 1995Assignee: The Regents of the University of CaliforniaInventors: C. Judson King, Loree J. Poole
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Patent number: 5411933Abstract: Antimicrobial compounds of the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are selected according to the following:A. R is (C.sub.11 -C.sub.16) alkyl (straight or branched), and R.sup.1 and R.sup.2 are joined to form a morpholine, pyrrolidine, or piperidine ring with the N;B. R is (C.sub.11 -C.sub.16) and R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.3) alkyl which in the case of C.sub.3 can be branched; andC. R.sup.1 and R.sup.2 are the same and are (C.sub.6 -C.sub.12) alkyl, straight or branched, and R is (C.sub.1 -C.sub.16) alkyl, straight or branched; andX.sup.- =an anion preferably selected from chlorine, bromine, iodine, phosphate, acetate, benzoate, citrate, tartrate, alkyl- or aryl-sulfonate, and alkylsulfate.Type: GrantFiled: March 11, 1994Date of Patent: May 2, 1995Assignee: Rohm & Haas CompanyInventor: Adam C. Hsu
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Patent number: 5391771Abstract: A process for the preparation of propane-1,2,3-tricarboxylic acid, tetrahydrofurfurylacetic acid and the C.sub.1 - to C.sub.20 -alkyl or C.sub.7 - to C.sub.12 -aralkyl esters thereof, propane-1,2,3-trimethanol, 3-methyltetrahydrofuran, 3-(2'-hydroxyethyl)tetrahydrofuran, 4-hydroxymethyltetrahydropyran, 2-methyl-.gamma.-butyrolactone and/or 3-methyl-.gamma.-butyrolactone, comprises reacting citric acid or the C.sub.1 - to C.sub.20 -alkyl or C.sub.7 - to C.sub.12 -aralkyl esters thereof on hydrogenation catalysts in non-aqueous solvents at from 50.degree. to 400.degree. C. and at from 1 to 400 bar.Type: GrantFiled: September 30, 1993Date of Patent: February 21, 1995Assignee: BASF AktiengesellschaftInventors: Hans-Juergen Weyer, Rolf Fischer, Christoph Sigwart
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Patent number: 5382681Abstract: A process for the preparation of an alkali metal citrate which comprises:(a) adjusting the pH of an aqueous solution containing citric acid to a value greater than 5.4;(b) contacting the aqueous solution with a polymeric adsorbent;(c) eluting the resulting charged polymeric adsorbent with an eluant comprising an aqueous solution of a soluble alkali metal hydroxide or alkali metal salt in which the alkali metal corresponds to the alkali metal of the alkali metal citrate to be produced; and(d) recovering an aqueous solution of the alkali metal citrate, is disclosed.Type: GrantFiled: September 17, 1993Date of Patent: January 17, 1995Assignee: Cerestar Holding B.V.Inventors: Frank G. H. Derez, Patrick L. J. Vandervondelen
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Patent number: 5349084Abstract: The present invention relates to a process for inexpensively and effectively recovering a high-purity organic acid, according to which a crude organic acid is subjected to extraction treatment with an organic solvent to obtain an organic solvent extract containing an organic acid; the organic solvent extract is mixed with a high-pressure gas to precipitate and separate impurities thereby obtaining a solution containing a high-purity organic acid; and the organic acid is separated from the solution to obtain a high-purity organic acid.Type: GrantFiled: September 25, 1991Date of Patent: September 20, 1994Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Akihiro Shishikura, Hiroshi Kimbara, Katsuhisa Yamaguchi, Kunio Arai
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Patent number: 5278256Abstract: The depolymerization of poly(hydroxyacids) in a liquid medium is enhanced by the presence of a quaternary ammonium compound. Poly(hydroxyacid) polymers containing a quaternary ammonium salt are more readily depolymerized.Type: GrantFiled: September 16, 1992Date of Patent: January 11, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventor: Harold E. Bellis
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Patent number: 5237098Abstract: A water-immiscible organic extractant system can economically be used to recover citric acid from molasses fermenter beer containing a high salt content by using a process combination of passing the aqueous raffinate from the citric acid extraction step through a basic anion-exchange resin to adsorb residual citric acid and release citrate anions from previously formed salt cation-citrate compounds. Trisodium citrate is then eluted from the resin by passing aqueous sodium hydroxide therethrough.Type: GrantFiled: October 9, 1992Date of Patent: August 17, 1993Assignee: Miles, Inc.Inventors: Timothy A. Bemish, John P. Chiang, Bhalchandra H. Patwardhan, David J. Solow
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Patent number: 5231225Abstract: The known liming sulfuric acid process for the recovery of crystalline citric acid from a fermentation broth is modified by subjecting the mother liquor from the crystallization to extraction with a water-immiscible organic extraction that contains an amine. The resulting extract is neutralized with a recycled brine with alkali citrate and alkali citrate is crystallized from the concentrated brine obtained this way.Type: GrantFiled: September 17, 1992Date of Patent: July 27, 1993Assignee: Innova S.A.Inventors: Avraham M. Baniel, Aharon M. Eyal
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Patent number: 5219602Abstract: An aqueous dispersion containing a finely divided reaction product of a calcium compound with citric acid having a mole ratio of calcium to citric acid from 2.5:2 to 2.95:2 is provided to be used for opacifying and whitening aqueous food compositions.Type: GrantFiled: December 20, 1991Date of Patent: June 15, 1993Assignee: Kraft General Foods, Inc.Inventors: Fouad Z. Saleeb, Susan M. Vidal
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Patent number: 5208372Abstract: A new and useful calcium salt of citric acid is prepared and is used as an anticaking agent in furctose-sweetened powdered soft drinks. Also included are the processes for preparing the new calcium salt and powdered beverage mixes containing the new salt.Type: GrantFiled: May 18, 1992Date of Patent: May 4, 1993Assignee: Kraft General Foods, Inc.Inventors: Susan Vidal, Fouad Z. Saleeb
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Patent number: 5189212Abstract: Nonsteroidal estrogenic triarylethylene carboxylic acids of the formula ##STR1## wherein R is (CH.sub.2).sub.m O or (CH.sub.2).sub.n, where m is an integer from 1 to 4 and n is an integer from 0 to 4, X is hydrogen or hydroxyl, Y is methyl, ethyl, chlorine, or bromine, and wherein the RCOOH and X moieties are either meta or para to the phenyl ethylene linkage. Examples of active compounds include 4-hydroxytamoxifen acid, 3-hydroxytamoxifen acid, 4-[1-(p-hydroxyphenyl)-2-phenyl-1-butenyl]benzoic acid and 4-[1-(p-hydroxyphenyl)-2-phenyl-1-butenyl]phenylacetic acid. Compositions containing these triarylethylene carboxylic acids can be administered to patients to alleviate medical conditions associated with a deficiency of estrogen, including osteoporosis, premenstrual syndrome, vasomotor symptoms associated with menopause, atrophic vaginitis, Kraurosis vulvae, female hypogonadism, primary ovarian failure, excessive hair growth and prThe U.S.Type: GrantFiled: September 7, 1990Date of Patent: February 23, 1993Assignee: University of Georgia Research Foundation, Inc.Inventor: Peter C. Ruenitz
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Patent number: 5186965Abstract: A metastable complex of calcium, citrate and malate is disclosed. This material is highly bioavailable, and is soluble in both neutral and acid solutions. The salt is prepared by the reaction of calcium carbonate, calcium hydroxide or calcium oxide with citric and malic acids in aqueous solution. The reaction mixture is dried at a temperature of less than 100.degree. C., and the resultant solid is a metastable solid. The solid can be ground to reduce the particle size for easier tabletting or adding to foods and beverages. Preferred salts are neutral and acidic salts which can be expressed by molar ratios.Type: GrantFiled: December 16, 1991Date of Patent: February 16, 1993Assignee: The Procter & Gamble CompanyInventors: Mary M. Fox, David C. Heckert, Kenneth R. Luhrsen
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Patent number: 5149552Abstract: A new and useful calcium salt of citric acid is prepared and is used as an anticaking agent in fructose-sweetened powdered soft drinks. Also included are the processes for preparing the new calcium salt and powdered beverage mixes containing the new salt.Type: GrantFiled: May 23, 1991Date of Patent: September 22, 1992Assignee: Kraft General Foods, Inc.Inventors: Susan Vidal, Fouad Z. Saleeb
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Patent number: 5108761Abstract: Acidic beverages, e.g. juices and carbonated beverages containing calcium citrate malate are disclosed. These beverages inhibit the erosion of tooth enamel that normally occurs during consumption of acidic beverages. A nutritional regimen of administering an acid beverage (pH below 5.5) containing from 35 mg to 270 mg calcium per 6 ounce (180 ml) serving (0.02% to 0.15% w/v of calcium) in the form of calcium citrate malate, for preventing tooth enamel erosion is disclosed. This beverage comprises water, sweetener and flavor or juice.Type: GrantFiled: October 1, 1990Date of Patent: April 28, 1992Assignee: The Procter & Gamble CompanyInventors: Mark B. Andon, Robert L. Kanerva, John T. Rotruck, Kenneth T. Smith
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Patent number: 5071874Abstract: L-carnitine magnesium citrate and a process for its production, starting from a magnesium compound, citric acid and L-carnitine, as well as the use of the product as a combination preparation in sports nutrition or as a pharmacological active ingredient.Type: GrantFiled: June 13, 1990Date of Patent: December 10, 1991Assignee: Lonza Ltd.Inventors: Thomas Scholl, Willibald F. Kohl
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Patent number: 5041645Abstract: Alkali metal citrates are prepared by the addition of an alkaline alkali metal base or salt to citric acid solutions and recovered in solid form by the addition of a C.sub.1 to C.sub.5 alcohol to the solution to cause precipitation.Type: GrantFiled: December 12, 1988Date of Patent: August 20, 1991Assignee: Haarmann & Reimer Corp.Inventors: Alexander Alon, Philip W. Staal
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Patent number: 5032686Abstract: Method for the recovery of citric acid from a liquor containing the same, wherein successively,in a first step, the liquor containing the citric acid is put into contact with a cationic resin in the hydrogen form during a duration sufficient to reach an optimal adsorption of the citric acid,in a second step, the resin is treated by means of an elution agent and the fraction of eluate rich in purified citric acid is recovered.Type: GrantFiled: June 5, 1989Date of Patent: July 16, 1991Assignee: Roquette FreresInventors: Pierrick Duflot, Jean-Bernard Leleu
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Patent number: 4997489Abstract: The invention relates to a process for recovering sugar, sugar alcohol and organic acids comprising citric, malic and quinic acids from a juice extracted from almond hulls. Residues from the extraction is also recovered.Type: GrantFiled: May 8, 1989Date of Patent: March 5, 1991Inventor: Israel N. Rabinowitz
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Patent number: 4994609Abstract: Recovery of citric acid from a citric acid fermentation broth.Type: GrantFiled: June 6, 1990Date of Patent: February 19, 1991Assignee: Innova S.A.Inventors: Avraham M. Baniel, David Gonen
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Patent number: 4985593Abstract: A dual mineral salt consisting essentially of magnesium, potassium and citrate. A method for manufacturing the subject salt in a form having a bulk density ranging from about 1.0 g/cc to about 1.3 g/cc is also disclosed, and the use of the subject salt as a dietary supplement are also disclosed.Type: GrantFiled: January 5, 1988Date of Patent: January 15, 1991Assignee: Mission Pharmacal Company, Inc.Inventors: Neill B. Walsdorf, George Alexandrides
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Patent number: 4950783Abstract: Compositions containing (-)-5-{(R)-1-Hydroxy-2[(R)-1-methyl-3-phenylpropyl)amino]ethyl}salicylamid e exhibit potent vasodilating .beta.-adrenergic blocking properties and are useful for the treatment of hypertension.Type: GrantFiled: October 24, 1986Date of Patent: August 21, 1990Assignee: Schering CorporationInventors: Elijah H. Gold, Wei K. Chang
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Patent number: 4895842Abstract: A phenylalanine derivative having the formula (I): ##STR1## where R.sup.1 and R.sup.2 are independently hydrogen provided that both R.sup.1 and R.sup.2 are not hydrogen at the same time;C.sub.1 -C.sub.8 alkyl which may be substituted with hydroxy, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, C.sub.1 -C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkoxy, carbamoyl, sulfamoyl, pyridyl, or phenyl which may further be substituted with nitro, C.sub.1 -C.sub.4 alkoxy, or halogen;C.sub.6 -C.sub.8 cycloalkyl which may be substituted with hydroxy, C.sub.1 -C.sub.4 alkoxy, hydroxylcarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, or C.sub.1 -C.sub.4 alkyl;phenyl which may be substituted with halogen, nitro, trifluoromethyl, C.sub.1 -C.sub.4 alkoxy C.sub.1 C.sub.4 alkylmercapto, C.sub.1 -C.sub.4 alkylcarbonyl, phenylcarbonyl, hydroxycarbonyl, C.sub.1 -C.sub.4 alkoxycarbonyl, carbamoyl, sulfamoyl, amidino, pyridylcarbonyl, or C.sub.1 -C.sub.6 alkyl which may further be substituted with C.sub.1 -C.sub.Type: GrantFiled: September 29, 1986Date of Patent: January 23, 1990Assignees: Shosuke Okamoto, Showa Denko Kabushiki KaishaInventors: Shosuke Okamoto, Yoshio Okada, Akiko Okunomiya, Taketoshi Naito, Yoshio Kimura, Morihiko Yamada, Norio Ohno, Yasuhiro Katsuura, Yumi Seki