Purification Or Recovery Per Se Patents (Class 562/593)
  • Patent number: 10179758
    Abstract: A method for crystallizing succinic acid includes agitating a succinic acid reaction solution with a jet-flow agitator that is rotated at low speed and has a low volume power density; compared with the conventional agitators, the jet-flow agitator helps increase the uniformity of succinic acid particles, shorten the time required for crystallizing succinic acid, and raise the yield of the crystallized succinic acid as well as purity of crystallized succinic acid having a purity of 99.8-99.9%.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: January 15, 2019
    Assignee: NAN YA PLASTICS CORPORATION
    Inventors: Te-Chao Liao, Jung-Jen Chuang, Cheng-Hsun Chen, Chia-Ruey Tsai, Chung-Yu Chen
  • Patent number: 10071947
    Abstract: The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 11, 2018
    Assignee: INVISTA North America S.à.r.l.
    Inventors: Gary J. Smith, Paul S. Pearlman, Gregory S. Kirby
  • Patent number: 9926255
    Abstract: High-purity dibasic acid compositions are generally disclosed. In some embodiments, the dibasic acid compositions are solutions or suspensions. In some other embodiments, the compositions are solid-state compositions. In some such embodiments, the solid-state compositions include a dibasic acid as a crystalline solid and further include a low quantity of certain impurities, such as monobasic acids, various esters, and the like. Methods and systems for making such high-purity dibasic acid compositions are also disclosed.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: March 27, 2018
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Alpeshkumar K. Patel, Brian Pease, Bradon J. Dreyer, Yenamandra Viswanath, Brian Albert, Steven A. Cohen
  • Patent number: 9879289
    Abstract: The present invention refers to a method for the preparation of 2-keto carboxylic acid having the general formula R1—CO—COOH, wherein R1 is a branched alkyl group having 3 to 7 carbon atoms, or a salt thereof, comprising a fermentation step wherein a microorganism is grown in a culture medium in order to provide a culture broth containing 2-keto carboxylic acid or a salt thereof.
    Type: Grant
    Filed: May 10, 2010
    Date of Patent: January 30, 2018
    Assignee: Evonik Degussa GmbH
    Inventors: Andreas Karau, Nicolas Morin, Robert Gerstmeir
  • Patent number: 9783833
    Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: October 10, 2017
    Assignee: INVISTA NORTH AMERICA S.A.R.L.
    Inventors: Paul S. Pearlman, Changlin Chen, Adriana Leonora Botes
  • Patent number: 9517996
    Abstract: A process for purifying a polycarboxylic acid from a mixture is provided. Optionally, the mixture is an aqueous solution and optionally the process comprises an acidification step and/or the use of one or more organic solvents. Also provided in part are compositions of polycarboxylic acids.
    Type: Grant
    Filed: June 12, 2015
    Date of Patent: December 13, 2016
    Assignee: Verdezyne, Inc.
    Inventors: Jose Laplaza, William Andrew Evanko, Jason H. Radany
  • Patent number: 9035095
    Abstract: Provided are processes for producing high-purity succinic acid from a succinic-acid-containing liquid through crystallization.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 19, 2015
    Assignee: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yoshiaki Mori, Go Takahashi, Hideki Suda, Shuji Yoshida
  • Patent number: 8987511
    Abstract: A method for producing crystals of adipic acid is described. In particular, a method for recovering adipic acid in the form of crystals with low impurity content, obtained by crystallization steps in particular using reaction media for synthesizing adipic acid is described. A purification method including a step of crushing the crystals for easier removal or the migration of the impurities in the crystals is also described.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: March 24, 2015
    Assignee: Rhodia Operations
    Inventors: Philippe Carvin, Stéphanie Foucher
  • Patent number: 8957249
    Abstract: A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which includes the following steps: 1) removal of the biomass and any solids present from the fermentation broth in two successive stages, 2) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, 3) fine purification of the dicarboxylic acid solution, 4) multistage evaporative concentration and crystallization, and 5) separation and drying of the crystals.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: February 17, 2015
    Assignee: Thyssenkrupp UHDE GmbH
    Inventors: Wolfgang Tietz, Joachim Schulze
  • Patent number: 8940934
    Abstract: An object of the present invention is to provide a production process of an ?-hydroxy acid having a sufficient quality as a polymer raw material, which process does not produce a large amount of waste as a byproduct and is economical. The present invention provides a production process of an ?-hydroxy acid having a step of adding a basic metal to an ?-hydroxy acid ammonium salt to yield an ?-hydroxy acid metal salt and a step of desalting the ?-hydroxy acid metal salt to yield the ?-hydroxy acid.
    Type: Grant
    Filed: June 20, 2008
    Date of Patent: January 27, 2015
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Makoto Okamoto, Hideki Date
  • Publication number: 20140371486
    Abstract: Disclosed is a method for removing and purifying carboxylic acids from fermentation broths, comprising removing biomass and any solids present from the fermentation broth, finely cleaning up the biomass-free and solids-free fermentation broth by nanofiltration, and removing the carboxylic acid from the finely cleaned, biomass-free, and solids free fermentation broth by adsorption to one or more solid phases having tertiary amino groups.
    Type: Application
    Filed: November 15, 2012
    Publication date: December 18, 2014
    Applicant: THYSSENKRUPP INDUSTRIAL SOLUTIONS AG
    Inventors: Joachim Schulze, Wolfgang Tietz, Isabel Waengler, Klaus Kuehlein
  • Publication number: 20140364632
    Abstract: The invention provides a method for preparing a carboxylic acid, which method includes the steps of providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate has a solubility in water at 20° C. of 80 g/100 g water or less; acidifying the magnesium carboxylate with HCl, thereby obtaining a solution comprising carboxylic acid and magnesium chloride (MgCl2); optionally a concentration step, wherein the solution comprising carboxylic acid and MgCl2 is concentrated; precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCl2, thereby obtaining a carboxylic acid precipitate and a MgCl2 solution.
    Type: Application
    Filed: August 16, 2012
    Publication date: December 11, 2014
    Applicant: PURAC BIOCHEM B.V.
    Inventors: André Banier De Haan, Jan Van Breugel, Paulus Loduvicus Johannes Van Der Weide, Peter Paul Jansen, José María Vidal Lancis, Agustín Cerdà Baró
  • Publication number: 20140349355
    Abstract: The invention pertains to method for recovering polycarboxylic acid from an aqueous mixture including the steps of: providing an aqueous mixture including polycarboxylic acid and at least 5 wt. % dissolved halide salt, based on the total weight of water and dissolved material in the aqueous mixture; extracting the polycarboxylic acid from the aqueous mixture into a first organic liquid including an organic solvent selected from the group consisting of ketones and ethers, thereby obtaining an organic polycarboxylic acid solution and an aqueous waste liquid including the halide salt; and extracting the polycarboxylic acid from the organic carboxylic acid solution into an aqueous liquid, thereby obtaining an aqueous polycarboxylic acid solution and a second organic liquid. The method according to the invention allows a combined purification and concentration step for feed solutions of polycarboxylic acids.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 27, 2014
    Applicant: PURAC BIOCHEM BV
    Inventors: André Banier De Haan, Jan Van Krieken, Tanja Dekic Zivkovic
  • Patent number: 8895779
    Abstract: A process for making MAA from a clarified DAA-containing fermentation broth includes (a) distilling the broth to form an overhead that includes water and ammonia, and a liquid bottoms that includes MAA, at least some DAA, and at least about 20 wt. % water; (b) cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a DAA-containing liquid portion in contact with a MAA-containing solid portion that is substantially free of DAA; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: November 25, 2014
    Assignee: BioAmber Inc.
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Patent number: 8895778
    Abstract: The invention provides energy efficient depolymerization of polyesters such as post-consumer polylactic acid. Ultrasonic induced implosions can be used to facilitate the depolymerization. The expanding market of polylactic acid-based plastic products, such as water bottles and packaging materials, has raised concerns of contaminating the recycling stream, which is largely filled with petroleum-based plastics. Thus the development of an energy efficient and economically viable PLA recycling process is urgently needed. Post consumer PLA was exposed to methanol as the suspension media in the presence of organic or ionic salts of alkali metals such a potassium carbonate and sodium hydroxide as depolymerization catalysts to provide high quality lactic acid monomers in high yield.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: November 25, 2014
    Assignee: Iowa State University Research Foundation
    Inventors: Gowrishankar Srinivasan, David Grewell
  • Publication number: 20140343317
    Abstract: A process for removing free carboxylic acid from an aqueous solution including a mass fraction of less than 1% wt of the free carboxylic acid. The process includes the steps of: (a) contacting the aqueous solution with a depleted solvent including a polyamine extractant to obtain an extract enriched in free carboxylic acid and a raffinate having a reduced free carboxylic acid content; and (b) separating the raffinate from the extract, wherein the polyamine extractant is a compound containing at least two nitrogen atoms, and at least one double bond between a nitrogen atom and a carbon atom.
    Type: Application
    Filed: January 17, 2013
    Publication date: November 20, 2014
    Inventors: André Banier De Haan, Agnieszka Krzyzaniak, Boelo Schuur
  • Patent number: 8829237
    Abstract: This invention provide processes for producing carboxylic acid product, along with useful salts. The carboxylic acid product that is produced according to this invention is preferably a C2-C12 carboxylic acid. Among the salts produced in the process of the invention are ammonium salts.
    Type: Grant
    Filed: March 3, 2011
    Date of Patent: September 9, 2014
    Assignee: The Michigan Biotechnology Institute
    Inventors: Robert J. Hanchar, Susanne Kleff, Michael V. Guettler
  • Publication number: 20140200365
    Abstract: The invention provides a method for preparing a succinic acid, which method includes the steps of: providing magnesium succinate; acidifying the magnesium succinate with hydrochloric acid (HCl), thereby obtaining a solution including succinic acid and magnesium chloride (MgCl2); optionally a concentration step, wherein the solution including succinic acid and MgCl2 is concentrated; precipitating succinic acid from the solution including succinic acid and MgCl2, thereby obtaining a succinic acid precipitate and a MgCl2 solution. The addition of HCl to a magnesium salt of succinic acid and subsequent precipitation of succinic acid from the solution leads to a very efficient separation of succinic acid from a magnesium succinate solution.
    Type: Application
    Filed: August 16, 2012
    Publication date: July 17, 2014
    Applicant: PURAC BIOCHEM B.V.
    Inventors: André Banier De Haan, Jan Van Breugel, Paulus Loduvicus Johannes Van Der Weide, Peter Paul Jansen, José MarÍa Vidal Lancis, AgustÍn Cerdà Baró
  • Publication number: 20140171614
    Abstract: By subjecting an organic acid derived from a biomass resource to oxidation treatment using an oxidizing agent such as hydrogen peroxide, tert-butylhydroperoxide, ozone, sodium hypochlorite or sodium chlorite, colored impurities contained in the organic acid derived from a biomass resource can be removed.
    Type: Application
    Filed: July 20, 2012
    Publication date: June 19, 2014
    Applicant: TORAY INDUSTRIES, INC.
    Inventors: Tetsuya Yamada, Masateru Ito, Katsushige Yamada, Kenji Kawamura
  • Patent number: 8729298
    Abstract: A method for the separation and purification of at least one long-chain diacid, comprising: introducing an impure preparation comprising at least one long-chain diacid to a stationary phase of a chromatograph; and eluting the at least one long-chain diacid from the stationary phase with at least one eluent.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: May 20, 2014
    Assignee: Cathay Industrial Biotech Ltd.
    Inventors: Huiqing Zang, Guang Lei, Bingbing Qin
  • Publication number: 20140081038
    Abstract: The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a plurality of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.
    Type: Application
    Filed: January 13, 2011
    Publication date: March 20, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Rafael Wilhelmus Elisabeth Ghislain Reintjens, Mehul Thathagar
  • Patent number: 8624059
    Abstract: Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: January 7, 2014
    Assignee: BioAmber S.A.S.
    Inventors: Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
  • Publication number: 20130184492
    Abstract: A process for making HOOC—R—COOH compound acid from a clarified NH4+?OOC—R—COO?NH4+ compound-containing fermentation broth including distilling the broth under super atmospheric pressure at a temperature of >I00° C. to about 250° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that Includes HOOC—R—COOH compound acid, and at least about 20 wt %. water; cooling the. bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion in contact with a solid portion that is substantially pure HOOC—R—COOH compound acid; separating the solid portion from the liquid portion; and recovering the solid portion.
    Type: Application
    Filed: April 15, 2011
    Publication date: July 18, 2013
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Publication number: 20130150621
    Abstract: Processes for removing color bodies from crude succinic acid comprising distillation of crude succinic acid and collecting the distillate in a water-containing receiver. The color bodies substantially remain in the distillation bottoms and the purified succinic acid in the water-containing receiver is substantially free of color bodies.
    Type: Application
    Filed: December 12, 2012
    Publication date: June 13, 2013
    Applicant: BioAmber S.A.S.
    Inventor: BioAmber S.A.S.
  • Publication number: 20130116471
    Abstract: An organic solvent free method for purifying and refining of a long-chain dicarboxylic acid or a salt thereof is disclosed. This method avoids problems caused by organic solvents which have been used in the purifying process of the prior art. This method reduces effectively the content of such impurities as proteins and coloring materials in the product. The purity of the crystallized long-chain dicarboxylic acid product is greater than 99 wt %.
    Type: Application
    Filed: April 26, 2012
    Publication date: May 9, 2013
    Applicants: SHANDONG HILEAD BIOTECHNOLOGY CO., LTD., INSTITUTE OF MICROBIOLOGY CHINESE ACADEMY OF SCIENCES
    Inventors: LIMING YAN, Yong Yang, Shenzhan Fu, Yuantong Chen, Zhizhou Wang, Wubo Cao
  • Publication number: 20130096343
    Abstract: A process for removing, isolating and purifying dicarboxylic acid from fermentation broths, which includes the following steps: 1) removal of the biomass and any solids present from the fermentation broth in two successive stages, 2) removal of the dicarboxylic acid solution from the biomass-free fermentation broth by simulated moving bed (SMB) chromatography, 3) fine purification of the dicarboxylic acid solution, 4) multistage evaporative concentration and crystallization, and 5) separation and drying of the crystals.
    Type: Application
    Filed: May 31, 2011
    Publication date: April 18, 2013
    Applicant: THYSSENKRUPP UHDE GMBH
    Inventors: Wolfgang Tietz, Joachim Schulze
  • Publication number: 20130018206
    Abstract: Provided are processes for producing high-purity succinic acid from a succinic-acid-containing liquid through crystallization.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: MITSUBISHI CHEMICAL CORPORATION
    Inventors: Yoshiaki MORI, Go Takahashi, Hideki Suda, Shuji Yoshida
  • Publication number: 20120289742
    Abstract: This present invention relates to the processes for the purification of succinic acid from a fermentation broth containing ammonium succinate. The process for the purification of succinic acid described in this invention involves the use of ion exchange resins for splitting the ammonium succinate in the fermentation broth. During the passage of the fermentation broth through a cationic ion exchange resin, the ammonium succinate is split into ammonium cation and the succinate anion. The proton on the resin surface is exchanged for the ammonium ions and the succinate anion is reduced to succinic acid with the protons released from the ion exchange resin. The bound ammonium is released from the resin with the addition of a strong acid such as sulfuric acid and thereby the ion exchange resin is regenerated for subsequent use. The ammonium sulfate by-product resulting from the regeneration step of this process can be used as a source of fertilizer.
    Type: Application
    Filed: December 31, 2010
    Publication date: November 15, 2012
    Inventors: Steven J. Gerberding, Ramnik Singh
  • Publication number: 20120253069
    Abstract: A method for the separation and purification of at least one long-chain diacid, comprising: introducing an impure preparation comprising at least one long-chain diacid to a stationary phase of a chromatograph; and eluting the at least one long-chain diacid from the stationary phase with at least one eluent.
    Type: Application
    Filed: February 13, 2012
    Publication date: October 4, 2012
    Inventors: Huiqing ZANG, Guang Lei, Bingbing Qin
  • Publication number: 20120238722
    Abstract: The present invention relates to a process for recovering succinic acid in crystal form from a fermentation broth comprising succinic acid, comprising the steps of a) bringing the fermentation broth to a pH of between 1 and 4, b) crystallizing the succinic acid from the fermentation broth to form succinic acid crystals, c) dissolving the succinic acid crystals at a temperature of between 30 and 90 degrees Celsius to form an aqueous solution comprising dissolved succinic acid, d) crystallizing the succinic acid from the solution to recover succinic acid in crystal form. The invention further relates to succinic acid in crystal form, comprising a sugar content of 1 to 100 ppm and a nitrogen content of 1 to 80 ppm.
    Type: Application
    Filed: November 19, 2010
    Publication date: September 20, 2012
    Applicants: ROQUETTE FRERES SA, DSM IP ASSETS B.V.
    Inventors: Maarten Job Van De Graaf, Fredoen Vallianpoer, Guillaume Fiey, Loic Delattre, Elisabeth Agnes Michèle Schulten
  • Patent number: 8263804
    Abstract: Hydrocarbon compounds having at least one nitrile function are converted into compounds having at least one carboxylic function by hydrating the nitrile functions into amide functions by reaction with water in the presence of a strong inorganic acid, and then hydrolyzing the amide functions into carboxylic functions by reaction with water and a strong inorganic acid; the carboxylic compounds thus obtained can be esterified into diesters, advantageously diester solvents.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: September 11, 2012
    Assignee: Rhodia Operations
    Inventors: Olivier Buisine, Philippe Leconte, Melanie Agati
  • Patent number: 8203021
    Abstract: Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: June 19, 2012
    Assignee: BioAmber S.A.S.
    Inventors: Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
  • Publication number: 20120095263
    Abstract: A method for producing crystals of adipic acid is described. In particular, a method for recovering adipic acid in the form of crystals with low impurity content, obtained by crystallization steps in particular using reaction media for synthesizing adipic acid is described. A purification method including a step of crushing the crystals for easier removal or the migration of the impurities in the crystals is also described.
    Type: Application
    Filed: June 7, 2010
    Publication date: April 19, 2012
    Inventors: Philippe Carvin, Stéphanie Foucher
  • Publication number: 20120040422
    Abstract: The present invention relates to a process for the production of a dicarboxylic acid and ethanol which comprises fermenting a genetically modified yeast in a suitable fermentation medium under anaerobic conditions at a pH value of between 1 and 5 and producing the dicarboxylic acid and ethanol.
    Type: Application
    Filed: March 23, 2010
    Publication date: February 16, 2012
    Applicant: DSM IP ASSET B.V.
    Inventors: Mickel Leonardus August Jansen, Maarten Job Van De Graaf, René Verwaal
  • Publication number: 20110269993
    Abstract: Processes for making AA from either a clarified DAA-containing fermentation broth or a clarified MAA-containing fermentation broth that include distilling the broth under super atmospheric pressure at a temperature of >100° C. to about 300° C. to form an overhead that comprises water and ammonia, and a liquid bottoms that includes AA, and at least about 20 wt % water; cooling the bottoms to a temperature sufficient to cause the bottoms to separate into a liquid portion and a solid portion that is substantially pure AA; and separating the solid portion from the liquid portion. A method also reduces the broth distillation temperature and pressure by adding an ammonia separating and/or water azeotroping solvent to the broth.
    Type: Application
    Filed: April 14, 2011
    Publication date: November 3, 2011
    Applicant: BIOAMBER S.A.S.
    Inventors: Olan S. Fruchey, Leo E. Manzer, Dilum Dunuwila, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Bernard D. Dombek
  • Patent number: 8034975
    Abstract: The present invention provides a method of manufacturing a highly pure ammonium succinate solution including the steps of (A) producing calcium succinate trihydrate by crystallization fermentation of a microorganism; (B) converting calcium succinate trihydrate to calcium succinate monohydrate by transition crystallization; (C) separating the calcium succinate monohydrate crystals; (D) substituting the calcium salt in the calcium succinate monohydrate with ammonium salt resulting in an ammonium succinate solution; and (E) removing the solid calcium carbonate from the ammonium succinate solution.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: October 11, 2011
    Assignee: Ajinomoto Co., Inc.
    Inventors: Kiyohiko Nishi, Hiroshi Kaneko, Hirofumi Tasaki, Masaki Koga, Tetsuo Tanegawa, Seisaku Furuya, Kenji Fujiwara, Takeru Sato
  • Publication number: 20110244534
    Abstract: A process for the preparation of a monovalent succinate salt includes: a) fermenting a carbohydrate source to succinic acid by means of a micro-organism, b) adding a alkaline earth metal hydroxide, carbonate and/or hydrogencarbonate, the alkaline earth metal being calcium or magnesium, as neutralising agent during the fermentation in an aqueous medium and causing the formation of calcium succinate or magnesium succinate, c) reacting the alkaline earth metal succinate salt in an aqueous medium with a monovalent hydroxide, carbonate and/or hydrogencarbonate base to form an alkaline earth metal hydroxide, carbonate and/or hydrogencarbonate and a monovalent succinate salt, d) separating the monovalent succinate salt from the alkaline earth metal hydroxide, carbonate and/or hydrogencarbonate, and e) recycling the alkaline earth metal hydroxide, carbonate and/or hydrogencarbonate to step b.
    Type: Application
    Filed: December 2, 2009
    Publication date: October 6, 2011
    Applicant: Purac Biochem BV
    Inventors: Jan Van Krieken, Jan Van Breugel
  • Publication number: 20110237831
    Abstract: Processes for making monoammonium succinate (MAS) and/or succinic acid (SA) from either a clarified diammonium succinate (DAS)-containing fermentation broth or a clarified MAS-containing fermentation broth include (a) distilling the broth to form an overhead that includes water and optionally ammonia and a liquid bottoms that includes MAS or SA; (b) cooling and/or evaporating the bottoms and optionally adding an antisolvent to the bottoms to attain a temperature and composition sufficient to cause the bottoms to produce a solid portion that contains MAS or SA in contact with a liquid portion; (c) separating the solid portion from the liquid portion; and (d) recovering the solid portion.
    Type: Application
    Filed: March 18, 2011
    Publication date: September 29, 2011
    Applicant: BioAmber S.A.S.
    Inventors: Olan S. Fruchey, Brian T. Keen, Brooke A. Albin, Nye A. Clinton, Dilum Dunuwila, Bernard D. Dombek
  • Patent number: 7915447
    Abstract: The present invention is intended to provide a process capable of efficiently producing highly purified succinic acid from an alkali metal succinate by a simple separation and purification process. The process for producing succinic acid in the present invention comprises (1) the step to add sulfuric acid into a solution containing an alkali metal succinate, (2) the step to precipitate and remove the crystal of an alkali metal sulfate from said solution, and (3) the step to precipitate and recover the crystal of succinic acid. The removal of the crystal of an alkali metal sulfate in the step (2) is performed by a solid-liquid separation in a state that the crystal of alkali metal sulfate is precipitated by concentrating and heating the solution that is obtained by adding sulfuric acid in the step (1) and succinic acid is dissolved in the solution.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: March 29, 2011
    Assignee: Showa Denko K.K.
    Inventors: Ichiro Fujita, Kouichi Wada
  • Patent number: 7896944
    Abstract: Methods for extracting molecules of fulvic acid from a humus material such as oxidized lignite are disclosed. The humus material is mixed with water to solubilize at least some of the fulvic acid molecules. A first filtration apparatus (which may be an ultrafiltration apparatus) may be used to separate at least some of the solubilized fulvic acid molecules from the humin and at least some of the humic acid molecules. A second filtration apparatus (which may be an ultrafiltration apparatus or a nanfiltration apparatus) may be used to then separate the fulvic acid molecules from most of the water and any remaining impurities. A digestion step may also be carried out where microorganisms are brought into contact with the mixture in the presence of oxygen in order to oxidize any unoxidized organic compounds in the humus material. Iron and aluminum may be precipitated and removed by the addition of a phosphate to improve the purity of the end-product.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: March 1, 2011
    Assignee: Lone Knight Limited
    Inventor: Michael Charles Karr
  • Publication number: 20110015434
    Abstract: The invention relates to a method for producing 1,2-dodeca-2,10-diene diacid and 1,12-dodecanoic acid whereby cyclooctene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting unsaturated dicarboxylic acid being precipitated and being hydrated in a second reaction step.
    Type: Application
    Filed: April 16, 2009
    Publication date: January 20, 2011
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Peter Hannen, Martin Roos, Harald Haeger
  • Publication number: 20100297715
    Abstract: The invention relates to methods for producing succinic acid and/or succinate ions by fermentation under anaerobic conditions.
    Type: Application
    Filed: December 15, 2008
    Publication date: November 25, 2010
    Applicant: ROQUETTE FRERES
    Inventors: Frederic Dehay, Laurent Segueilha, Olivier Calande, Caroline Varlamoff
  • Publication number: 20100137639
    Abstract: The present invention provides an improved method for preparing, purifying, precipitating, etc., a subject compound for use in a subsequent reaction carried out in suspension. The present invention relies on a precipitating solvent being added to an aqueous solution comprising the subject compound to form a precipitate of the subject compound, which may be further dried and/or purified. Compositions made according to present methods have improved characteristics and properties, such as increased surface and/or reduced density, resulting in a higher reactivity in a subsequent reaction carried out in suspension.
    Type: Application
    Filed: November 24, 2009
    Publication date: June 3, 2010
    Applicant: Innovative Technologies, L.L.C.
    Inventor: Keith R. LATHAM
  • Publication number: 20100105925
    Abstract: An improved process for synthesis of duloxetine hydrochloride (1) having chiral purity greater than 99.
    Type: Application
    Filed: March 5, 2008
    Publication date: April 29, 2010
    Applicant: LUPIN LIMITED
    Inventors: Rajinder Singh Siyan, Sunil Kumar Vinubhai Gohel, Girij Pal Singh
  • Publication number: 20090234160
    Abstract: The present invention is intended to provide a process capable of efficiently producing highly purified succinic acid from an alkali metal succinate by a simple separation and purification process. The process for producing succinic acid in the present invention comprises (1) the step to add sulfuric acid into a solution containing an alkali metal succinate, (2) the step to precipitate and remove the crystal of an alkali metal sulfate from said solution, and (3) the step to precipitate and recover the crystal of succinic acid. The removal of the crystal of an alkali metal sulfate in the step (2) is performed by a solid-liquid separation in a state that the crystal of alkali metal sulfate is precipitated by concentrating and heating the solution that is obtained by adding sulfuric acid in the step (1) and succinic acid is dissolved in the solution.
    Type: Application
    Filed: June 12, 2007
    Publication date: September 17, 2009
    Inventors: Ichiro Fujita, Kouichi Wada
  • Patent number: 7504536
    Abstract: A process for producing a calcium citrate malate composition by the steps of: combining a calcium source, a citrate source, a malate source and water to form a calcium citrate malate mixture. The mixture is reacted until reaching a peak temperature of from about 45° C. to about 70° C., and then cooled at a rate of from about 1° C./minute to about 4° C./minute to reach a final temperature of less than about 40° C. A calcium citrate malate precipitate is formed and then dried to obtain the calcium citrate malate composition.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: March 17, 2009
    Assignee: The Procter & Gamble Company
    Inventors: Ashok Premchand Luhadiya, Timothy William Dake, Glenn Richard Hudepohl, Donald Brown Compton
  • Patent number: 7470370
    Abstract: A process is disclosed that relates to the recovery of a metal catalyst from an oxidizer purge stream produced in the synthesis of carboxylic acid, typically terephthalic. More particularly, the process involves recovery of a metal catalyst from an oxidizer purge stream through the use of a pressure filter, the combining of water with a mother liquor to recover the metal catalyst and then subjecting an aqueous mixture so formed to a single stage extraction with an extraction solvent to produce an extract stream comprising organic impurities and a raffinate stream comprising the metal catalyst.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: December 30, 2008
    Assignee: Eastman Chemical Company
    Inventors: Kenny Randolph Parker, Robert Lin
  • Patent number: 7411090
    Abstract: The invention provides a process for the recovery of citric acid from an aqueous solution feed stream originating in fermentation of carbohydrates and utilizing an amine solvent extraction step for separation of impurities comprising: subjecting said aqueous solution feed stream A to a treatment for partial recovery of citric acid, wherein said treatment is other than amine solvent extraction, to form a first portion of purified citric acid B and a secondary feed stream F; subjecting at least a portion G of said secondary feed stream F to a treatment consisting of amine solvent extraction to form a second portion of purified citric acid solution and to reject substantial of impurities initially present in said portion of said secondary feed stream; subjecting said second portion of purified citric acid solution to crystallization; and recycling mother liquor from said crystallization.
    Type: Grant
    Filed: March 3, 2004
    Date of Patent: August 12, 2008
    Assignee: A.E. Staley Manufacturing Company
    Inventors: Avraham Baniel, Asher Vitner, David Gonen, David Heidel
  • Patent number: 7371890
    Abstract: A process for continuously preparing a compound which bears at least two functional groups which are each independently selected from the group consisting of nitrile group, carboxylic acid group, carboxylic ester group and carboxamide group.
    Type: Grant
    Filed: June 11, 2004
    Date of Patent: May 13, 2008
    Assignee: BASF Aktiengesellschaft
    Inventors: Wolfram Stüer, Jens Scheidel, Hartwig Voβ, Peter Baβler, Michael Röper
  • Patent number: 7282151
    Abstract: A process is disclosed that relates to the recovery of a metal catalyst from an oxidizer purge stream produced in the synthesis of carboxylic acid, typically terephthalic. More particularly, the process involves recovery of a metal catalyst from an oxidizer purge stream through the use of a pressure filter, the combining of water with a mother liquor to recover the metal catalyst and then subjecting an aqueous mixture so formed to a single stage extraction with an extraction solvent to produce an extract stream comprising organic impurities and a raffinate stream comprising the metal catalyst.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: October 16, 2007
    Assignee: Eastman Chemical Company
    Inventors: Kenny Randolph Parker, Robert Lin