Unsaturated Patents (Class 562/595)
  • Patent number: 9266898
    Abstract: A reaction product of the co-dehydration of a sugar alcohol and a reactant polyol having a number average hydroxyl functionality less than 4.0 is disclosed. In some aspects the sugar alcohol comprises mannitol, sorbitol, xylitol, erythritol, or mixtures thereof. In some preferred aspects the sugar alcohol comprises sorbitol. In some aspects the reactant polyol has an average molecular weight of from 40 to 500 Daltons. In some aspects, the reaction product may be suitable for the manufacture of polyisocyanurate foam. In some aspects the reaction product may be mixed with diluent polyols, such as diols, glycols, ethylene glycol, diethylene glycol, dipropylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol and mixtures thereof.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: February 23, 2016
    Assignee: Cargill, Incorporated
    Inventors: Timothy Walter Abraham, Donald Michael Ference, Wei Zhang
  • Patent number: 9126922
    Abstract: Efficient methods for the production of long-chain unsaturated dicarboxylic compounds are disclosed. Unsaturated dicarboxylic compounds may be prepared from a reaction mixture containing unsaturated carboxylic compounds in the presence of one or more catalysts. In addition to the unsaturated dicarboxylic compounds, alkene compounds may also be produced. The alkene compounds may be removed from the reaction mixture under reduced pressure. The method may also use a wiped-film still as a means to remove the alkene compounds from the reaction mixture. Reaction conditions may be monitored and/or controlled through the use of one or more electronic system(s) in communication with a variety of sensors and controllable devices.
    Type: Grant
    Filed: March 26, 2012
    Date of Patent: September 8, 2015
    Assignee: Empire Technology Development LLC
    Inventor: Tapsak Mark Allan
  • Publication number: 20150064111
    Abstract: The invention relates to compounds and use thereof in the diagnosis and/or in treatment of medical disorders. In some embodiments, the compounds may be used for detecting a cancer. The compound may include a di-acid moiety. In some embodiments the di-acid moiety comprises a di-carboxylic acid and in some embodiments the di-acid moiety comprises a di-tetrazole.
    Type: Application
    Filed: April 3, 2013
    Publication date: March 5, 2015
    Applicant: APOSENSE LTD.
    Inventors: Joel M. Van Gelder, Menashe Levy, Mirit Argov, Miri Ben-Ami, Ilan Ziv
  • Publication number: 20150018574
    Abstract: A self-metathesis process for the production of unsaturated dicarboxylic fatty diacids and/or unsaturated dicarboxylic fatty diesters, wherein unsaturated carboxylic fatty acids and/or esters of unsaturated carboxylic fatty acids are reacted in the presence of at least one defined ruthenium based catalyst compound. A catalyst enhancer compound selected from a sacrificial catalyst or a non-catalyst enhancer may also be used. The process exhibits improved reaction times and/or the catalyst can be used at very low concentrations.
    Type: Application
    Filed: March 18, 2013
    Publication date: January 15, 2015
    Applicant: CRODA INTERNATIONAL PLC
    Inventors: Bastiaan Wels, Hans Ridderikhoff, Tanja Van Bergen-Brenkman, Dessy Liminto
  • Patent number: 8916610
    Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: December 23, 2014
    Assignees: Ramot at Tel-Aviv University Ltd., Bar-Ilan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul, Efrat Halbfinger
  • Publication number: 20140357877
    Abstract: A method for preparing a carboxylic acid, includes the steps of: providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate is selected from the group made of 2,5-furandicarboxylic acid, fumaric acid, adipic acid, itaconic acid, citric acid, glutaric acid, maleic acid, malonic acid, oxalic acid and fatty acids having more than 10 carbon atoms; acidifying the magnesium carboxylate with hydrogen chloride (HCl), thereby obtaining a solution including carboxylic acid and magnesium chloride (MgCl2); optionally a concentration step, wherein the solution including carboxylic acid and MgCl2 is concentrated; and precipitating the carboxylic acid from the solution including the carboxylic acid and MgCl2, thereby obtaining a carboxylic acid precipitate and a MgCl2 solution.
    Type: Application
    Filed: August 16, 2012
    Publication date: December 4, 2014
    Applicant: PURAC BIOCHEM B.V.
    Inventors: André Banier De Haan, Jan Van Breugel, Paulus Loduvicus Johannes Van Der Weide, Peter Paul Jansen, José María Vidal Lancis, Agustín Cerdà Baró
  • Publication number: 20140309433
    Abstract: Described herein are compounds and methods of catalyzing ethenolysis reactions, optionally on an industrial scale. In certain embodiments, the catalysts bear cyclic alkyl amino carbene (CAAC) ligands with an ortho substituent, such as a methyl substituent, on an N-aryl ring. When used to catalyze ethenolysis reactions, certain such compounds produce a turnover number greater than 50,000.
    Type: Application
    Filed: April 10, 2014
    Publication date: October 16, 2014
    Inventors: Vanessa M. Marx, Mohand-Ameziane Melaimi, Scott C. Virgil, Benjamin K. Keitz, Robert H. Grubbs, Guy Bertrand
  • Publication number: 20140243549
    Abstract: The present invention relates to novel non-aqueous gels of natural oils and their derivatives and provides a novel process for the gelation of natural oils and their derivatives that does not require the addition of gellants or the irreversible heat bodying of the oil. The gels and method of the present invention are applicable to a wide range of natural oils, and the method is easily tailored to provide thermoreversible gels of any desired viscosity. The natural oil based gels of the present invention and the method of their preparation have many advantages over the prior art. The natural oil based gels provided have exemplary properties and find use in a variety of applications.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 28, 2014
    Inventor: James T. Tanner
  • Publication number: 20140243550
    Abstract: Novel natural oil derived ink vehicles are provided by a two step process that does not require the addition of gelants or the irreversible heat bodying or polymerization of the oil. The gelled natural oil may be used as the vehicle/carrier in the ink formulation or alternatively used as a carrier or dispersant for additives in ink formulations. The gelled ink vehicles disclosed have many advantages over ink vehicles disclosed in the prior art.
    Type: Application
    Filed: February 25, 2013
    Publication date: August 28, 2014
    Inventor: James T. Tanner
  • Publication number: 20130323193
    Abstract: The present invention provides an oil-soluble deodorant composition that is highly safe, efficienctly eliminates odors of ammonia, amines and the like and is free of an irritant odor and the like. The present invention relates to an oil-soluble deodorant composition containing at least one of a dimer acids and a trimer acids as an active ingredient.
    Type: Application
    Filed: March 2, 2012
    Publication date: December 5, 2013
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Takashi Kawano, Takahiro Ishikawa, Sadahiko Yamazaki, Kunihide Hoshino
  • Publication number: 20130289112
    Abstract: Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
    Type: Application
    Filed: March 21, 2011
    Publication date: October 31, 2013
    Applicant: TIANJIN CHASESUN PHARMACEUTICAL CO., LTD
    Inventors: Jiang Zheng, Xinchuan Zheng, Xin Liu, Hong Zhou, Ning Wang, Hongwei Cao, Yan Li, Yongling Lu, Kecen Zhao, Jingcheng Yang, Yang Yang, Yuanfeng Zhu, Guo Wei, Min Huang
  • Publication number: 20130237626
    Abstract: The invention relates to radiation curable compositions comprising a liquid 0/s(acyl)phosphine photo initiators of formula (I): wherein each of Ar1, Ar2 and Ar3 is independently a substituted or unsubstituted aryl group. The invention also relates to stabilized forms of liquid bis(acyl)phosphines of formula (I) and radiation curable composition comprising said stabilized photoinitiators. The radiation curable compositions are selected from the group consisting of an optical fiber coating composition and a coating composition capable of radiation cure on concrete and a coating composition capable of radiation cure on metal.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 12, 2013
    Applicant: DSM IP Assets B.V.
    Inventors: Timothy Edward BISHOP, Edward Joseph Murphy, John Edmond Southwell, Satyendra Sarmah, TaiYeon Lee
  • Publication number: 20130231300
    Abstract: A fraction separated from crude crocetin by preparative HPLC, and identified using LC/MS and NMR as crocetinic acid, markedly regressed the proliferation and increased apoptosis in pancreatic cancer cells. Purified crocetinic acid showed more potency than 15 commercial or crude crocetin using proliferation and apoptosis as markers. Purified crocetinic acid also showed significant anti-tumorigenic activity against pancreatic cancer cells in a mouse model of pancreatic cancer. Given crocetinic acid's low toxicity, crocetinic acid could be used as a chemotherapeutic or chemopreventative agent for pancreatic cancer.
    Type: Application
    Filed: October 7, 2011
    Publication date: September 5, 2013
    Applicant: U.S. Department of Veterans Affairs
    Inventors: Animesh Dhar, William G. Gutheil
  • Publication number: 20130190417
    Abstract: The disclosure provides anionic Gemini surfactants comprising at least two carbonyl moieties and at least two aliphatic moieties. In some aspects, at least two of the aliphatic moieties comprise at least seven carbon atoms and at least one pair of conjugated carbon-to-carbon double bonds. The anionic Gemini surfactants are polymerizable and may be used to prepare triply periodic multiply continuous lyotropic phase and polymers thereof that substantially retain triply periodic multiply continuous lyotropic phase structure.
    Type: Application
    Filed: January 23, 2013
    Publication date: July 25, 2013
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventor: Wisconsin Alumni Research Foundation
  • Publication number: 20130184347
    Abstract: An acid addition salt of a nortriptyline-GABA conjugate, a novel crystalline form of a fumaric acid addition salt of a nortriptyline-GABA conjugate, and processes of preparing the forgoing are disclosed. Uses of the above-indicated forms of a nortriptyline-GABA conjugate in the treatment of CNS disorders, and in the treatment of pain in particular, are also disclosed. Further disclosed in a large-scale process of preparing a nortriptyline-GABA conjugate.
    Type: Application
    Filed: September 22, 2011
    Publication date: July 18, 2013
    Applicants: Ramot at Tel-Aviv University Ltd., BioLineRX Ltd., Bar-llan University
    Inventors: Abraham Nudelman, Ada Rephaeli, Irit Gil-Ad, Abraham Weizman, Mazal Shaul
  • Patent number: 8450519
    Abstract: The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: May 28, 2013
    Assignee: Reuter Chemischer Apparatebau KG
    Inventors: Milan Soukup, Karl Reuter, Florian Stolz, Viktor Meier, Jofzsef Balint, Mark Kantor
  • Patent number: 8445720
    Abstract: The invention relates to a method for producing ?,?-unsaturated dicarboxylic acids and the corresponding saturated dicarboxylic acids, whereby the corresponding cycloalkene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting dicarboxylic acid being precipitated.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: May 21, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Peter Hannen, Martin Roos, Harald Haeger
  • Patent number: 8431742
    Abstract: The invention relates to a method for producing 1,2-dodeca-2,10-diene diacid and 1,12-dodecanoic acid whereby cyclooctene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting unsaturated dicarboxylic acid being precipitated and being hydrated in a second reaction step.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: April 30, 2013
    Assignee: Evonik Degussa GmbH
    Inventors: Peter Hannen, Martin Roos, Harald Haeger
  • Patent number: 8420840
    Abstract: A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives.
    Type: Grant
    Filed: December 2, 2011
    Date of Patent: April 16, 2013
    Inventor: Edwin S. Olson
  • Publication number: 20130090314
    Abstract: Provided herein are novel solid state forms of tapentadol salts, process for their preparation, pharmaceutical compositions, and method of treating thereof. The tapentadol salts include an L-(?)-camphorsulfonate salt, a dibenzoyl-(L)-tartrate salt, a dibenzoyl-(D)-tartrate salt, a malate salt, a maleate salt, or a salicylate salt.
    Type: Application
    Filed: September 11, 2012
    Publication date: April 11, 2013
    Applicant: ACTAVIS GROUP PTC EHF
    Inventors: Mayur Devjibhai Khunt, Sandipan Prabhurao Bondge, Nitin Sharadchandra Pradhan, Depashri Vikas Ahirao
  • Publication number: 20120315681
    Abstract: The patent application relates to a method of producing a monomer component from a genetically modified polyhydroxyalkanoate (PHA) biomass, wherein the biomass is heated in the presence of a catalyst to release a monomer component from the PHA.
    Type: Application
    Filed: February 11, 2011
    Publication date: December 13, 2012
    Inventors: Johan van Walsem, Erik Anderson, John Licata, Kevin A. Sparks, Christopher Mirley, M.S. Sivasubramanian
  • Publication number: 20120309842
    Abstract: The present invention provides processes and intermediates for preparing cinacalcet base and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: September 16, 2010
    Publication date: December 6, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Sayeed Mukhtar, Dinesh Shashidharan Nair, Roshan Ramesh Medhane, Nitin Maheshwari, Hashim Nizar Poovanathil Nagoor Meeran, Neera Tewari, Mohan Prasad
  • Publication number: 20120178959
    Abstract: The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned.
    Type: Application
    Filed: March 16, 2012
    Publication date: July 12, 2012
    Inventors: Milan SOUKUP, Karl Reuter, Florian Stolz, Viktor Meier, Jofzsef Balint, Mark Kantor
  • Publication number: 20120178809
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: March 14, 2012
    Publication date: July 12, 2012
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Publication number: 20120129969
    Abstract: The invention relates to radiation curable compositions comprising a liquid 0/s(acyl)phosphine photo initiators of formula (Ï): wherein each of Ar1, Ar2 and Ar3 is independently a substituted or unsubstituted aryl group. The invention also relates to stabilized forms of liquid bis(acyl)phosphines of formula (I) and radiation curable composition comprising said stabilized photoinitiators. The radiation curable compositions are selected from the group consisting of an optical fiber coating composition and a coating composition capable of radiation cure on concrete and a coating composition capable of radiation cure on metal.
    Type: Application
    Filed: June 21, 2011
    Publication date: May 24, 2012
    Inventors: Timothy Edward Bishop, Edward Joseph Murphy, John Edmond Southwell, Satyendra Sarmah, TaiYeon Lee
  • Publication number: 20120130125
    Abstract: An improved process for preparing ammonium salts from fumaric or succinic acid, is described. The method consists of neutralizing the corresponding acid carbonate or ammonium bicarbonate at a molar stoichiometric or greater than the stoichiometric ratio of 4-5% in a saturated aqueous solution of the synthesized salt at a temperature not exceeding 40° C., followed by separation of the product and drying at a temperature not exceeding 70° C. After separation of the ammonium salts, the filtrate can be re-used. Isolation of the product is usually carried out by cooling the reaction mixture to a temperature of 15-18C°. The product comes out in almost crystalline form. Saturated aqueous solution of the synthesized salt is formed by the interaction of carbonate or ammonium bicarbonate with the appropriate acid at a temperature not exceeding 40° C. It is possible to obtain cleaner salt concentration weighing more than 99% and not yielding lower than 98%.
    Type: Application
    Filed: August 24, 2009
    Publication date: May 24, 2012
    Inventors: Roman Anatolievich Trunin, Mikhail Lvovich Uchitel, Evgenij Iljich Maevskij, Vladimir Izrailevich Heifets, Svetlana Yakovlevna Chernitzkaya, Donna Kasseinova, Galina Nikolaevna Ermakova
  • Publication number: 20120101168
    Abstract: The subject invention provides deuterated rasagiline, its salts and uses.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 26, 2012
    Inventors: Eliezer Bahar, Anton Frenkel, Victor Piryatinsky
  • Publication number: 20120095099
    Abstract: The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.
    Type: Application
    Filed: August 5, 2011
    Publication date: April 19, 2012
    Applicant: Diffusion Pharmaceuticals LLC
    Inventors: John L. Gainer, Marc Lanz
  • Publication number: 20120071457
    Abstract: A new metallo-?-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of ?-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-?-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of ?-lactam antibiotics against metallo-?-lactamase producing bacteria by combining the compound of the general formula (I) with ?-lactam antibiotics.
    Type: Application
    Filed: November 29, 2011
    Publication date: March 22, 2012
    Inventors: Ken Chikauchi, Mizuyo Ida, Takao Abe, Yukiko Hiraiwa, Akihiro Morinaka, Toshiaki Kudo
  • Patent number: 8071799
    Abstract: A method comprising providing a starting composition comprising a polyunsaturated fatty acid, a polyunsaturated fatty ester, a carboxylate salt of a polyunsaturated fatty acid, a polyunsaturated triglyceride, or a mixture thereof; self-metathesizing the starting composition or cross-metathesizing the starting composition with at least one short-chain olefin in the presence of a metathesis catalyst to form self-/cross-metathesis products comprising: cyclohexadiene; at least one olefin; and one or more acid-, ester-, or salt-functionalized alkene; and reacting cyclohexadiene to produce at least one cycloalkane or cycloalkane derivatives.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: December 6, 2011
    Assignee: Energy & Environmental Research Center Foundation
    Inventor: Edwin S. Olson
  • Publication number: 20110251286
    Abstract: Salts and/or co-crystals of (+)-3-[2-(dimethylamino)-methyl-1-hydroxycyclohexyl]-phenol or of (?)-3-[2-(dimethylamino)methyl-1-hydroxy-cyclohexyl]phenol, present in crystalline form, with cinnamic acid, C8- to C10-alkane-monocarboxylic acids, C6- to C10-alkanedicarboxylic acids, C15- to C17-alkane-monocarboxylic acids, fumaric acid, tartaric acid, mandelic acid, hippuric acid and/or embonic acid, a process for their production, and the use of such salts and/or co-crystals as medicaments.
    Type: Application
    Filed: March 9, 2011
    Publication date: October 13, 2011
    Applicant: GRUENENTHAL GmbH
    Inventors: Michael GRUSS, Oswald Zimmer
  • Patent number: 7964743
    Abstract: Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: June 21, 2011
    Assignee: Japan Science and Technology Agency
    Inventors: Norio Miyaura, Yasunori Yamamoto
  • Publication number: 20110137047
    Abstract: The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially rennin inhibitors such as Aliskiren. The invention describes a preparation of enantiomerically pure 8-aryloctanoic acids of general formula I from readily available key intermediate, chiral cis-diacid of formula II, aziridine of formula XI and a monocyclic compound of formula III.
    Type: Application
    Filed: October 15, 2010
    Publication date: June 9, 2011
    Applicant: CarboDesign LLC
    Inventor: Milan Soukup
  • Publication number: 20110124889
    Abstract: A process for the oxidation of alcohol and/or aldehyde groups with a peroxo compound in the presence of a heterogeneous rhenium based catalyst, and a co-catalyst. The process of the invention may, for example, be applied to the manufacture of maleic acid which can be dehydrated to lead to maleic anhydride.
    Type: Application
    Filed: July 16, 2009
    Publication date: May 26, 2011
    Applicant: SOLVAY SA
    Inventors: Raffaele Saladino, Angela Farina
  • Publication number: 20110111994
    Abstract: A polyalkenyl succinic anhydride is prepared with low amounts of resinous or chlorinated byproducts in a two-step process whereby a polyalkene is first reacted with an unsaturated organic acid in a thermal ene reaction, followed with exposure to a gaseous halogen in presence of an additional amount of the unsaturated organic acidic reagent. The foregoing process produces a polyisobutenyl succinic anhydride having a high ratio of succinic anhydride functional groups to polyisobutenyl backbone groups. Such a polyisobutenyl succinic anhydride is particular suitable for the production of oil-soluble hydrocarbyl succinimides that have good dispersant properties when added to lubricating oil compositions.
    Type: Application
    Filed: January 19, 2011
    Publication date: May 12, 2011
    Applicant: AFTON CHEMICAL CORPORATION
    Inventors: Chente Huang, John T. Loper
  • Publication number: 20110112200
    Abstract: The present invention provides crystalline and amorphous salts of O-desmethylvenlafaxine and processes for preparing said salts of O-desmethylvenlafaxine. The present invention further provides pharmaceutical compositions comprising said salts of O-desmethylvenlafaxine.
    Type: Application
    Filed: June 16, 2009
    Publication date: May 12, 2011
    Inventors: Valerie Niddam-Hildesheim, Tamar Nidam, Eli Lancry
  • Publication number: 20110046230
    Abstract: Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 24, 2011
    Applicant: Gruenenthal GmbH
    Inventors: Michael GRUSS, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
  • Publication number: 20110015434
    Abstract: The invention relates to a method for producing 1,2-dodeca-2,10-diene diacid and 1,12-dodecanoic acid whereby cyclooctene and acrylic acid are reacted with a ruthenium catalyst by way of a metathesis reaction at high substrate concentrations until the reaction takes place in substance, the resulting unsaturated dicarboxylic acid being precipitated and being hydrated in a second reaction step.
    Type: Application
    Filed: April 16, 2009
    Publication date: January 20, 2011
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Peter Hannen, Martin Roos, Harald Haeger
  • Publication number: 20100310467
    Abstract: The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fumarate and imaging media comprising hyperpolarised 13C-fumarate for use in said method.
    Type: Application
    Filed: December 18, 2008
    Publication date: December 9, 2010
    Inventors: Anna Gisselsson, Georg Hansson, Sven Mansson, Rene In't Zandt, Magnus Karlsson, Pernille R. Jensen, Mathilde H. Lerche
  • Publication number: 20100184998
    Abstract: The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 22, 2010
    Inventors: Beatriz Dominguez, Alan Dyke, William Hems, Christian Mathes, Anthony C. O'Sullivan, Gottfried Sedelmeier
  • Publication number: 20100150851
    Abstract: Novel compositions comprising anionic-cationic complexes as conditioning agents for use in products that improve the appearance and feel of skin and hair are well known. This invention describes the use of additional cationic surfactant in combination with an anionic-cationic complex made from a fatty alkyl dialkylamine and a “dicarboxylic acid”, preferably a dimer acid. This combination provides exceptional conditioning for hair, improving both wet and dry combing. It also makes very stable oil-in-water emulsions, and adds a slippery feel and lubricity to shaving and skin cleaning products.
    Type: Application
    Filed: April 11, 2008
    Publication date: June 17, 2010
    Applicant: ALZO INTERNATIONAL, INC.
    Inventors: Albert A. Zofchak, John Carson, Paul Slavashevich
  • Publication number: 20100048696
    Abstract: The present invention provides a disinfectant comprising as an active ingredient maleic acid and/or maleic anhydride.
    Type: Application
    Filed: January 11, 2008
    Publication date: February 25, 2010
    Applicant: Idemitsu Kosan Co., Ltd.
    Inventors: Kazuo Sumi, Kazuyoshi Koike, Shinji Ito
  • Patent number: 7622597
    Abstract: Method of preparation of maleimides by thermal cyclization of maleamic acids in the presence of a catalyst consists in that reaction of a substituted maleic anhydride with a primary amine is performed in an organic solvent in the presence of betaine at a temperature of 100 to 180° C., at a ratio of the primary amine to the substituted maleic anhydride of 0.6:1.6. Maleimides, obtained in this way, are further purified by extraction, and finally, they are crystallized. As a catalyst, there may be also used betaine in a mixture with inorganic and organic acids, or betaine may be deposited on a solid carrier, or possibly, betaine may be deposited on a carrier in combination with inorganic acids.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: November 24, 2009
    Assignee: Vucht A.S.
    Inventors: Zsolt Vegh, Jozef Balko
  • Publication number: 20090264672
    Abstract: Described are methods of making organic compounds by metathesis chemistry. The methods of the invention are particularly useful for making industrially-important organic compounds beginning with starting compositions derived from renewable feedstocks, such as natural oils. The methods make use of a cross-metathesis step with an olefin compound to produce functionalized alkene intermediates having a pre-determined double bond position. Once isolated, the functionalized alkene intermediate can be self-metathesized or cross-metathesized (e.g., with a second functionalized alkene) to produce the desired organic compound or a precursor thereto. The method may be used to make bifunctional organic compounds, such as diacids, diesters, dicarboxylate salts, acid/esters, acid/amines, acid/alcohols, acid/aldehydes, acid/ketones, acid/halides, acid/nitriles, ester/amines, ester/alcohols, ester/aldehydes, ester/ketones, ester/halides, ester/nitriles, and the like.
    Type: Application
    Filed: April 10, 2009
    Publication date: October 22, 2009
    Applicant: Elevance Renewable Sciences, Inc.
    Inventors: Timothy W. Abraham, Hiroki Kaido, Choon Woo Lee, Richard L. Pederson, Yann Schrodi, Michael John Tupy
  • Publication number: 20090163715
    Abstract: A compound represented by the general formula below or a salt thereof is a useful intermediate in the production of a [2-(3,3,5,5-tetramethylcyclohexyl)phenyl]piperazine compound that has excellent cell adhesion inhibitory effect and cell invasion inhibitory effect and therefore is useful as a therapeutic or prophylactic agent for various inflammatory diseases and autoimmune diseases induced by the adhesion and invasion of leukocytes, such as inflammatory bowel diseases (particularly ulcerative colitis or Crohn's disease), irritable bowel syndrome, rheumatoid arthritis, psoriasis, multiple sclerosis, asthma and atopic dermatitis. wherein R1 and R2 independently represent hydrogen or a protecting group for an amino group, or R1 and R2 bond together to form an optionally substituted pyrrole ring.
    Type: Application
    Filed: May 25, 2006
    Publication date: June 25, 2009
    Applicant: EISAI R&D MANAGEMENT CO., LTD.
    Inventors: Mitsuo Nagai, Kazumasa Nara, Kazunori Wakasugi, Toshihiko Naito
  • Publication number: 20090156849
    Abstract: Compounds represented by the following general formula (1a) or (1b). A complex comprising a center metal of rhodium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for optically active beta-substituted carbonyl compound synthesis and catalyst for asymmetric 1, 2 addition reaction being composed of the complex. A method of production of an optically active beta-aryl compound from an alpha, beta-unsaturated compound and an aryl-boronic acid derivative and method of production of an optically active aryl alcohol compound from an aldehyde compound and aryl boronic acid derivatives using the catalyst. A complex comprising a center metal of palladium and a compound represented by the following general formula (1a) or (1b) as a ligand. A catalyst for asymmetric allylic substitution reaction being composed of the complex.
    Type: Application
    Filed: February 17, 2006
    Publication date: June 18, 2009
    Inventors: Norio Miyaura, Yasunori Yamamoto
  • Patent number: 7534917
    Abstract: A method of producing dicarboxylic acids (e.g., ?,? dicarboxylic acids) by reacting a compound having a terminal COOH (e.g., unsaturated fatty acid such as oleic acid) and containing at least one carbon-carbon double bond with a second generation Grubbs catalyst in the absence of solvent to produce dicarboxylic acids. The method is conducted in an inert atmosphere (e.g., argon, nitrogen). The process also works well with mixed unsaturated fatty acids obtained from soybean, rapeseed, tall, and linseed oils.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: May 19, 2009
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Helen Ngo, Thomas A. Foglia
  • Publication number: 20090095200
    Abstract: The present invention relates to a modified colored pigment comprising a colored pigment having an attached organic group. The organic group is attached to the colored pigment via at least one carbon atom of a C—C single bond or double bond, wherein the C—C single bond or double bond is not a component of an aromatic system. The organic group further comprises at least one activating group on at least one carbon atom of the C—C single bond or double bond. A method of preparing a modified colored pigment is also disclosed, as are aqueous and non-aqueous dispersions, e.g., including ink jet inks, comprising the modified colored pigments.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 16, 2009
    Inventors: James A. Belmont, Elizabeth G. Burns
  • Publication number: 20080269459
    Abstract: A process for the preparation of a saturated dicarboxylic acid, comprising the steps of (a) contacting a conjugated diene with carbon monoxide and water to obtain a mixture containing an ethylenically unsaturated acid product and one or more reversible adducts of the conjugated diene and the ethylenically unsaturated acid; and (b) reacting the ethylenically unsaturated acid product further with carbon monoxide and water to obtain the dicarboxylic acid, wherein step (a) and (b) are performed in the presence of a catalyst system including a source of palladium, a source of an anion and a bidentate phosphine ligand, and wherein in step (a) the water concentration is maintained at a range of from 0.001 to less than 3% by weight of water, calculated on the overall weight of the liquid reaction medium, and wherein in step (b) the water concentration is maintained at a range of from 3% to 50% by weight of water, calculated on the overall weight of the liquid reaction medium.
    Type: Application
    Filed: February 10, 2006
    Publication date: October 30, 2008
    Inventors: Eit Drent, Rene Ernst, Willem Wabe Jager, Cornelia Alida Krom
  • Patent number: 7348455
    Abstract: A process for producing (meth)acrylic acid or (meth)acrylic acid esters, which comprises a reaction step comprising vapor phase catalytic oxidation of propylene, propane or isobutylene and, if necessary, a reaction step comprising an esterification step, characterized in that at the time when a high boiling mixture (hereinafter referred to as a high boiling material) containing a Michael addition product, is decomposed in a decomposition reactor to recover (meth)acrylic acids, while forcibly imparting a liquid flow in the circumferential direction to a liquid reaction residue in the decomposition reactor, the liquid reaction residue is discharged. In a process for recovering a valuable substance by thermally decomposing the high boiling material containing the Michael addition product of (meth)acrylic acids, it is possible to transfer the decomposition residue from the decomposition reactor to the storage tank without clogging, whereby a long-term continuous operation is possible.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: March 25, 2008
    Assignee: Mitsubishi Chemical Corporation
    Inventors: Shuhei Yada, Yasushi Ogawa, Yoshiro Suzuki, Kiyoshi Takahashi, Kenji Takasaki