Halogen Patents (Class 562/596)
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Patent number: 8834743Abstract: Aliphatic dicarboxylate Gemini surfactants and lyotropic liquid crystal compositions formed thereby are disclosed. The Gemini surfactants are capable of robustly forming Q phase morphologies over broad ranges of temperature and concentration.Type: GrantFiled: May 16, 2012Date of Patent: September 16, 2014Assignee: Wisconsin Alumni Research FoundationInventors: Mahesh Kalyana Mahanthappa, Gregory Paul Sorenson, Keiva LaNee Coppage
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Patent number: 8536269Abstract: The present invention provides peroxidic fluoropolyether and a fluorine-containing dispersion obtained from polymerization of fluorine-containing monomers in the presence of peroxidic fluoropolyether as a surfactant. The peroxidic fluoropolyether can be used as surfactant for producing aqueous dispersion of fluorine-containing monomer in place of PFOA or the salts thereof. Thus the amount of PFOA or the salts thereof is reduced and the natural environment is protected. In addition, applying peroxidic fluoropolyether as surfactant and combining it with adjuvants, such as initiator, can induce the reaction moderate and can be beneficial to the polymerization control, thus reducing the amount of initiator or shortening the reaction time.Type: GrantFiled: August 15, 2008Date of Patent: September 17, 2013Assignee: Nova-Duct Technologies Pty LtdInventors: Xueduan Xie, Jun Qu, Rong Bai, Jianxin Zhang, Xucang Yang, Bo Chen, Jingang Zhang, Ming Zhang, Xianquan Hu, Yu Cheng
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Publication number: 20130108610Abstract: The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.Type: ApplicationFiled: October 28, 2011Publication date: May 2, 2013Inventors: James Robert SCHWARTZ, Charles Winston Saunders, Robert Scott Youngquist, Jun Xu
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Publication number: 20130071332Abstract: Imaging agents are described that comprise labeled substrates capable of being introduced into cells via the cystine/glutamate antiporter. The substrates may be used for imaging or detecting oxidative stress in cells by introducing the labeled agents into cells via the cystine/glutamate antiporter and subsequent detection.Type: ApplicationFiled: September 16, 2011Publication date: March 21, 2013Applicant: GENERAL ELECTRIC COMPANYInventors: Jack Mathew Webster, Bruce Fletcher Johnson, Brian Duh-Lan Lee, Chittari Pabba, Michael James Rishel
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Publication number: 20130052585Abstract: Provided are novel symmetrical and asymmetrical bifunctional photodecomposable bases (PDBs) with dicarboxylate anion groups that show increased imaging performance. Also provided are photoresist compositions prepared with the bifunctional dicarboxylated PDBs and lithography methods that use the photoresist compositions of the present invention.Type: ApplicationFiled: August 26, 2011Publication date: February 28, 2013Applicants: JSR CORPORATION, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Ramakrishnan Ayothi, William D. Hinsberg, Sally A. Swanson, Gregory M. Wallraff
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Publication number: 20110257434Abstract: The invention relates to compounds that selectively bind to cells undergoing perturbations and alterations of their normal plasma membrane organization, i.e., cells undergoing cell death, apoptotic cells or activated platelets. The invention further provides methods for utilizing the compounds in medical practice, for diagnostic and therapeutic purposes.Type: ApplicationFiled: April 14, 2011Publication date: October 20, 2011Inventors: Ilan ZIV, Anat Shirvan
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Publication number: 20110110854Abstract: The present application discloses compositions and methods of synthesis and use of 68Ga, 18F or 19F labeled molecules of use in PET or MRI imaging. Preferably, the 18F or 19F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a chelating moiety, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 68Ga, 18F or 19F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. In more preferred embodiments, a chelating moiety or targetable construct may be conjugated to a targeting molecule, such as an antibody or antibody fragment.Type: ApplicationFiled: December 2, 2010Publication date: May 12, 2011Applicant: IMMUNOMEDICS, INC.Inventors: William J. McBride, Christopher A. D'Souza, David M. Goldenberg
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Publication number: 20100324330Abstract: The composition for preventing development-defects containing (1) an ammonium salt, a tetraalkylammonium salt or a C1 to C4 alkanolamine salt of C4 to C15 perfluoroalkylcarboxylic acid, C4 to C10 perfluoroalkylsulfonic acid and perfluoroadipic acid, or (2) a fluorinated alkyl quaternary ammonium salt of inorganic acid, wherein said surfactant is formed at the equivalent ratio of acid to base of 1:1-1:3 is applied on a chemically amplified photoresist coating on a substrate having a diameter of 8 inches or more. The chemically amplified photoresist coating is baked before and/or after applying the composition for preventing development-defects described above. Then, the baked coating with the development-defect preventing composition coating is exposed to light, post-exposure-baked, and developed.Type: ApplicationFiled: August 10, 2010Publication date: December 23, 2010Inventors: Yasushi Akiyama, Yusuke Takano, Kiyohisa Takahashi, Sung-Eun Hong, Tetsuo Okayasu
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Publication number: 20100022771Abstract: The present invention is directed at obtaining a high yield of a target substance and simultaneously securing high productivity. A reaction apparatus 10 has: a main flow channel 12 having an inner diameter of 3 mm, in which a raw material M1 flows; an introduction flow channel 14 in which a raw material M2 that causes a chemical reaction with the raw material M1 flows; and five branch introduction flow channels 16a to 16e which are branched from the introduction flow channel 14 and introduce the raw material M2 to the main flow channel 12, at predetermined introduction points 12o to 12s in the main flow channel 12. Here, in the main flow channel 12, the flow channel lengths of the flow channels 12b to 12d between adjacent introduction points 12p to 12s are not longer than those of the flow channels 12a to 12c between the next previous adjacent introduction points 12o to 12r in a flow direction of the raw material M1.Type: ApplicationFiled: September 14, 2007Publication date: January 28, 2010Inventors: Noriyuki Yoneda, Yuichi Oda, Yasuo Nakanishi
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Patent number: 7247747Abstract: An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formu (I): where X1 and X2, which may be the same or different, are hydroxy, C1-C4 alkoxy, phenoxy, halogen, or X1 and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.Type: GrantFiled: July 7, 2005Date of Patent: July 24, 2007Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Piero Melloni, Alberto Cerri, Marco Santagostino
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Patent number: 6984739Abstract: An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): where X1 and X2, which may be the same or different, are hydroxy, C1–C4 alkoxy, phenoxy, halogen, or X1 and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, a mesyloxy or a tosyloxy group, and subsequent treatment with water, then with a base and then with trimethylamine.Type: GrantFiled: November 20, 2003Date of Patent: January 10, 2006Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Piero Melloni, Alberto Cerri, Marco Santagostino
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Patent number: 6677476Abstract: An inner salt of L-carnitine is prepared by reduction, with a suitable reducing agent, of a compound of formula (I): where X1 and X2, which may be the same or different, are hydroxy, C1-C4 alkoxy, phenoxy, halogen, or X1 and X2, when taken together are an oxygen atom and the resulting compound is a derivative of succinic anhydride; Y is halogen, the mesyloxy or the tosyloxy group: and subsequent treatment with water, then with a base and then with trimethylamine.Type: GrantFiled: November 6, 2001Date of Patent: January 13, 2004Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Piero Melloni, Alberto Cerri, Marco Santagostino
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Patent number: 6046292Abstract: Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the carboxylic acid results in mesogens that are capable of forming thermotropic and single-phase lyotropic mesophases over a broad range of compositions. The mesophases can be polymerized to lock in the ordered phases.Type: GrantFiled: February 3, 1999Date of Patent: April 4, 2000Assignee: The Univeristy of Southern MississippiInventors: Robert Y Lochhead, Lon J Mathias
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Patent number: 5905127Abstract: Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the carboxylic acid results in mesogens that are capable of forming thermotropic and single-phase lyotropic mesophases over a broad range of compositions. The mesophases can be polymerized to lock in the ordered phases.Type: GrantFiled: April 8, 1997Date of Patent: May 18, 1999Assignee: The University of Southern MississippiInventors: Robert Y Lochhead, Lon J Mathias
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Patent number: 5463111Abstract: Dialkyl 2-haloethyl malonates are prepared from a dialkyl cyclopropane-1,1-dicarboxylate by reaction with a hydrogen halide in the presence of a 1,2-dialkoxy ethane as a solvent and of a Friedel-Crafts catalyst.Type: GrantFiled: August 8, 1994Date of Patent: October 31, 1995Assignee: Huls AktiengesellschaftInventor: Klaus-Dieter Steffen
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Patent number: 5414095Abstract: An anhydride-functional primary alkyl halide having the structure: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.2 are each individually hydrogen or methyl, and the total number of carbon atoms in R.sup.1 and R.sup.2 and R.sup.3 combined is two or less. The compounds are useful in the synthesis of polymers, etc.Type: GrantFiled: January 3, 1994Date of Patent: May 9, 1995Assignee: The Sherwin-Williams CompanyInventor: Rodney M. Harris
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Patent number: 5112507Abstract: Novel copolymers of unsaturated acidic reactants and high molecular weight olefins wherein at least 20 percent of the total high molecular weight olefin comprises the alkylvinylidene isomer are useful as dispersants in lubricating oils and fuels and also may be used to prepare polysuccinimides and other post-treated additives useful in lubricating oils and fuels.Type: GrantFiled: September 29, 1989Date of Patent: May 12, 1992Assignee: Chevron Research and Technology CompanyInventor: James J. Harrison
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Patent number: 5101068Abstract: The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.Type: GrantFiled: February 16, 1990Date of Patent: March 31, 1992Assignee: Prototek Inc.Inventor: James T. Palmer
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Patent number: 4990652Abstract: The reaction products of the alpha-halogenated half esters or amides of succinic acid and thiadiazole dimercaptides as new compositions of matter and their use as lubricant additives possessing multifunctional properties such as extreme pressure, antiwear, antioxidant and anticorrosion.Type: GrantFiled: November 21, 1989Date of Patent: February 5, 1991Assignee: Atochem North America, Inc.Inventors: James P. King, Sameeh S. Toukan
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Patent number: 4927962Abstract: A fluorocarbon carboxylic acid Rf(COOH).sub.m (Rf is C.sub.1 -C.sub.10 perfluoroalkyl group, m is 1 or 2) is prepared by the steps of hydrolyzing Rf(COF).sub.m with water to obtain an acidic solution, neutralizing the acidic solution with aqueous solution of KOH to form Rf(COOK).sub.m, precipitating and separating Rf(COOK).sub.m from the solution and converting Rf(COOK).sub.m into Rf(COOH).sub.m by acid decomposition. The content of free fluorine can extremely be reduced by treating Rf(COOK).sub.m with sulfuric acid and silica. The mother liquor is recycled after removing KF by treatment with a metal hydroxide and replenishing with KOH. In preparing a fluorocarbon sulfonic acid RfSO.sub.3 H (Rf is C.sub.1 -C.sub.3 perfluoroalkyl group) in substantially the same way, RfSO.sub.3 K is formed in aqueous solution of KOH by bringing gaseous RfSO.sub.2 F into contact with the KOH solution under normal pressure, while controlling the feed rate of RfSO.sub.Type: GrantFiled: August 29, 1988Date of Patent: May 22, 1990Assignee: Central Glass Company, LimitedInventors: Minoru Aramaki, Hiroaki Sakaguchi, Tamio Nakamura
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Patent number: 4908385Abstract: The present invention provides pharmaceutical compositions containing at least one .alpha.-halogenated dicarboxylic acid of the general formula: ##STR1## wherein Hal is a chlorine, bromine or fluorine atom, R is a hydrogen atom or Hal and m is a number of from 4 to 16, and/or at least one pharmacologically acceptable salt, ester or amide thereof.The present invention also provides new compounds of general formula (I) but in which m is a number of from 8 to 16 and processes for the preparation thereof.Type: GrantFiled: October 6, 1987Date of Patent: March 13, 1990Assignee: Epis S.A.Inventors: Jacob Bar-Tana, Yoelit Migron, Jochanan Blum, Bruno Dreckmann, Johannes Pill
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Patent number: 4736059Abstract: The present process produces the meso dialkyl 2,5-dihaloadipate from a mixture of the racemic dialkyl 2,5-dihaloadipate and meso 2,5-dihaloadipate. In the disclosed process, a 2,5-dihaloadipoyl halide is formed under conditions which result in the formation of an acidic compound. The 2,5-dihaloadipoyl halide is then esterified under conditions wherein the ester of the dihaloadipoyl halide is allowed to remain in contact with the acidic compound, thus allowing the racemic diester to epimerize in the presence of the acidic compound to the meso form and then the meso diester spontaneously crystallizes. In the last stage, the meso diester produced is removed.Type: GrantFiled: August 7, 1987Date of Patent: April 5, 1988Assignee: Pfizer Inc.Inventors: Brian T. O'Neill, Harry A. Watson, Jr.
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Patent number: 4689344Abstract: A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism, useful for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. The active compounds have the general formula ##STR1## or in-vivo hydrolyzable functional derivatives of the carboxylic groups thereof,whereinR.sub.1 and R.sub.2 each independently represents an unsubstituted or substituted hydrocarbyl or hetercyclyl radical;X and Y each independently represents hydrogen, optionally substituted lower alkyl, halogen, cyano, carboxy, lower alkoxycarbonyl or carbamoyl; andQ represents a diradical consisting of a linear chain of 8 to 14 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteratom chain members optionally forming part of a ring structure.Type: GrantFiled: June 22, 1984Date of Patent: August 25, 1987Assignee: Epis S.A.Inventor: Jacob Bar-Tana
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Patent number: 4634795Abstract: A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism. The active compounds have the general formula ##STR1## or in-vivo hydrolysable functional derivatives of the carboxylic groups thereof, whereinR.sub.1 and R.sub.2 each independently represents an unsubstituted or substituted hydrocarbyl or heterocyclyl radical;X and Y each independently represent hydrogen, optionally substituted lower alkyl, halogen, cyano, carboxy, lower alkoxycarbonyl or carbamoyl; andQ represents a diradical consisting of a linear chain of 8 to 14 carbon atoms, one or more of which may be replaced by heteroatoms, said chain being optionally substituted by inert substituents and one or more of said carbon or heteroatom chain members optionally forming part of a ring structure.Type: GrantFiled: August 27, 1985Date of Patent: January 6, 1987Assignee: Epis S.A.Inventor: Jacob Bar-Tana
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Patent number: 4578503Abstract: An alkylated or alkenylated malonic ester having a fluorine containing aliphatic substituent and derivatives thereof as expressed by the following general formula: ##STR1## where R.sub.f is a fluorine containing aliphatic group, R is an aliphatic group, or hydrogen or alkali metal atom, and R' is an unsubstituted or substituted aliphatic group.And a method to trap the enolate ion of a malonic ester having a fluorine containing aliphatic substituent as expressed by the following general formula,R.sub.f CH(CO.sub.2 R).sub.2where R.sub.f is a fluorine containing aliphatic group and R is an aliphatic group, hydrogen or alkali metal atom, wherein said malonic ester is converted under the action of a weaker base and/or fluoride ion to a fluorine containing enolate ion to be trapped as expressed by the following general formula:R.sub.f C.sup..crclbar. (CO.sub.2 R).sub.2where R.sub.f and R are the same as above.Type: GrantFiled: August 31, 1983Date of Patent: March 25, 1986Assignee: Daikin Kogyo Co., Ltd.Inventors: Nobuo Ishikawa, Takeshi Nakai, Yoshio Inouye
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Patent number: 4503206Abstract: Tetrafluoroethylene is reacted in an aqueous environment with hydroxyl radicals, generating a mixture of water soluble and water insoluble .alpha.,.omega.-perfluorodicarboxylic acids.Type: GrantFiled: December 22, 1982Date of Patent: March 5, 1985Assignee: Indiana University FoundationInventor: Ivan M. Robinson
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Patent number: 4479901Abstract: Process for fluorinating an organic carbanion, which process comprises contacting and reacting, in a dry inert atmosphere, the compound of the formula selected from ##STR1## wherein ##STR2## is the carbanion, M is a counter ion, and X is a halide and a selected N-flouro-N-alkylsulfonamide.Type: GrantFiled: August 15, 1983Date of Patent: October 30, 1984Assignee: E. I. Du Pont de Nemours and CompanyInventor: William E. Barnette
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Patent number: 4346235Abstract: A novel fluorine-containing compound of the formulaR.sub.1 --A--R.sub.2whereinA is ##STR1## R.sub.1 and R.sub.2 are each hydrogen or R.sub.3 OOC--CH.sub.2).sub.n, while R.sub.1 and R.sub.2 may not be hydrogen at the same time; X is hydrogen or halogen; R.sub.3 is hydrogen or a lower alkyl group; m is an integer of 1 to 5; and n is an integer of 4 to 11, and a process for preparing the same.Type: GrantFiled: June 10, 1980Date of Patent: August 24, 1982Assignees: Okamura Oil Mill Limited, Daikin Kogyo Co., Ltd.Inventors: Noboru Sonoda, Shinji Murai, Kazuhisa Takii
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Patent number: 4282156Abstract: Novel polyfunctional compounds and a process for their preparation are disclosed. These compounds and their alkali metal salts are useful metal sequestrants and/or detergent builders. Selected compounds are also intermediates useful in the syntheses of aconitic acid as well as isocitric and alloisocitric acids and their lactones. The novel polyfunctional compounds are obtained from the reaction of maleic anhydride with selected active methylene or methane containing compounds.Type: GrantFiled: April 1, 1980Date of Patent: August 4, 1981Assignee: Lever Brothers CompanyInventor: Eddie N. Gutierrez
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Patent number: 4281119Abstract: An apparatus and process useful in direct fluorination of a variety of compositions, as well as the fluorinated compositions themselves, are disclosed.The apparatus comprises a cryogenic zone reactor, such as a packed column reactor, suitably divided into a plurality of independently controllable cryogenic temperature zones. Means are also provided to introduce a reactant to be fluorinated as well as to introduce a mixture of fluorine gas and an inert gas.New fluorinated compounds are also disclosed. These include: perfluoro-2-methoxyethyl ether; perfluoro-1,4-dioxane; perfluoro-2,5-diketohexane; perfluorohexamethylethane; and monohydropentadecafluoroadamantane.Additionally, new syntheses for trifluoroacetic acid, a commercially significant bulk chemical, are disclosed. One synthesis comprises producing perfluoroethyl acetate by direct fluorination using a cryogenic zone reactor, followed by hydrolysis of perfluoroethyl acetate. Two moles of the acid are produced for each mole of ester.Type: GrantFiled: June 23, 1976Date of Patent: July 28, 1981Assignee: Massachusetts Institute of TechnologyInventors: Richard J. Lagow, James L. Adcock, Norma J. Maraschin
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Patent number: 4241223Abstract: F-phenylalkylene oxide acetylenes having the formula C.sub.6 F.sub.5 C.tbd.C(CF.sub.2 OCF.sub.2).sub.n C.tbd.CC.sub.6 F.sub.5, where n ranges from 3 to 8, inclusive. The diacetylenes are useful as monomers for preparing fluorinated polyether elastomers.Type: GrantFiled: August 28, 1979Date of Patent: December 23, 1980Assignee: The United States of America as represented by the Secretary of the Air ForceInventor: Keith B. Baucom
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Patent number: 4201876Abstract: A fluorinated polyether is synthesized by (1) reacting perfluoroglutryl chloride and 1,5-hexafluoropentane diol to provide a fluorinated polyester and (2) converting ester groups of the polyester to ether groups by SF.sub.4 reduction. The product obtained is a thermally stable polyether which is particularly useful in providing an elastomeric material for aircraft fuel tank sealants, tire valves, O-rings, hose, gaskets, and the like.Type: GrantFiled: December 8, 1976Date of Patent: May 6, 1980Assignee: The United States of America as represented by the Secretary of the Air ForceInventor: Warren R. Griffin