Plural Carboxamide Groups Containing Or Containing Plural Carbonyls Bonded Directly To The Same Nitrogen Patents (Class 564/152)
- Two carboxamido carbonyls having benzene ring between the carbonyls and no carboxamido nitrogen between the carbonyls (Class 564/156)
- Amino nitrogen, not bonded directly to carbonyl, containing (Class 564/157)
- Hydroxy, bonded directly to carbon, or ether containing (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) (Class 564/158)
-
Patent number: 8168579Abstract: The invention is directed to a fluid detergent composition comprising a di-amido gellant and a surfactant, and a method for structuring said composition.Type: GrantFiled: March 11, 2011Date of Patent: May 1, 2012Assignee: The Procter and Gamble CompanyInventors: Susana Fernandez Prieto, Johan Smets, Beatriu Escuder Gil, Juan Felipe Miravet Celades, Vincent Josep Nebot Carda
-
Patent number: 8158827Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable for transfection or delivery of compounds to target cells, either in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules, particularly polyanions such as nucleic acids. These compounds have the property, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.Type: GrantFiled: January 14, 2009Date of Patent: April 17, 2012Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Publication number: 20120071528Abstract: The invention is directed to novel compounds of Formula I: as well as its stereoisomers and/or pharmaceutically acceptable salts, for the treatment of diabetes and diabetes associated dyslipidemia.Type: ApplicationFiled: September 20, 2011Publication date: March 22, 2012Applicant: KAREUS THERAPEUTICS, SAInventors: Ish Khanna, Sivaram Pillarisetti
-
Publication number: 20120071664Abstract: Disclosed are ?-amino acids that are unsubstituted in the ? position; that are substituted in the ? position with an aryl group; that are substituted in the ? position with an aryl group; that bear two substituents in the ? position; and/or that are substituted in the ? and ? positions with groups which, together with the carbon atoms at the ? and ? positions, form a ring. Also disclosed are methods for making the above-mentioned ?-amino acids and other ?-amino acids which involve providing an ?,?-unsaturated imide; converting the ?,?-unsaturated imide to a 2-substituted-isoxazolidin-5-one; and converting the 2-substituted-isoxazolidin-5-one to a ?-amino acid.Type: ApplicationFiled: September 20, 2011Publication date: March 22, 2012Applicant: NDSU Research FoundationInventors: Mukund P. SIBI, Craig P. Jasperse, Prabagaran Narayanasamy, Sandeep R. Ghorpade
-
Patent number: 8124817Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.Type: GrantFiled: October 19, 2010Date of Patent: February 28, 2012Assignee: Merck Patent GmbHInventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
-
Publication number: 20120027844Abstract: Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compound or a composition comprising a compound are also described.Type: ApplicationFiled: February 9, 2010Publication date: February 2, 2012Applicants: XAVIER UNIVERSITY OF LOUISIANA, TULANE UNIVERSITYInventors: Barbara S. Beckman, Maryam Foroozesh, Jiawang Liu
-
Publication number: 20120022263Abstract: The present invention herein provides a 3-aminooxalylaminobenzamide derivative which is used as an insecticide or miticide. The 3-aminooxalylaminobenzamide derivative is one represented by the following general formula [1]: (R1 and R2 each represent, for instance, a C1 to C3 alkoxy group or a C1 to C3 haloalkoxy group; R3 and R4 each represent, for instance, a C1 to C8 alkyl group or a C1 to C8 haloalkyl group; R5 represents, for instance, a C1 to C5 haloalkyl group; R6 and R7 each represent, for instance, a hydrogen atom or a C1 to C5 alkyl group; Y represents, for instance, a hydrogen atom or a halogen atom; Z represents, for instance, a hydrogen atom; n is an integer ranging from 0 to 4 and m is an integer ranging from 0 to 2).Type: ApplicationFiled: February 5, 2010Publication date: January 26, 2012Applicant: AGRO-KANESHO Co., Ltd.Inventors: Shuichi Usui, Toshiki Fukuchi, Sachiko Kinoshita
-
Patent number: 8088763Abstract: Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including these compounds and related methods of treating or inhibiting certain diseases or conditions.Type: GrantFiled: November 9, 2006Date of Patent: January 3, 2012Assignee: Gruenenthal GmbHInventors: Corinna Sundermann, Bernd Sundermann
-
Publication number: 20110319454Abstract: The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.Type: ApplicationFiled: June 24, 2011Publication date: December 29, 2011Applicant: ALLERGAN, INC.Inventors: Richard L. Beard, John E. Donello, Vidyasagar Voligonda, Michael E. Garst
-
Patent number: 8066974Abstract: The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing urea or urethane functions allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.Type: GrantFiled: May 10, 2007Date of Patent: November 29, 2011Assignee: GE Healthcare ASInventors: Duncan Wynn, Harry John Wadsworth, Ian Martin Newington
-
Patent number: 8034840Abstract: The invention relates to pharmaceutically acceptable salts of guanylhydrazone-containing compounds, for example, Semapimod. The invention also relates to pharmaceutically acceptable compositions comprising the salts and methods for their use.Type: GrantFiled: June 22, 2007Date of Patent: October 11, 2011Assignee: Cytokine PharmaSciences, Inc.Inventor: Thais M. Seilecki-Dzurdz
-
Publication number: 20110224459Abstract: The invention relates to new ?-hydroxyalkylamides, to a method for production of same and to the use of same.Type: ApplicationFiled: March 12, 2010Publication date: September 15, 2011Applicant: EVONIK DEGUSSA GmbHInventors: Werner Grenda, Emmanouil Spyrou
-
Patent number: 8013183Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: GrantFiled: February 23, 2010Date of Patent: September 6, 2011Assignee: ViroBay, Inc.Inventors: Michael Graupe, John O. Link, Michael G. Roepel
-
Publication number: 20110152466Abstract: The invention is based on the discovery that a remarkable improvement in the performance of maleimide thermosets can be achieved by incorporating amide-extended maleimides into an adhesive formulation. Amide-extended maleimides described herein can be used to toughen bismaleimide thermosetting materials without sacrificing any thermal stability. Amide-extended maleimides are readily prepared by reacting a bismaleimide with an appropriate amine via the well-known Michael addition reaction. Acylation of the resulting secondary amines provides the amide-extended maleimide. The acylating agent can also be used to introduce polymerizable functional groups into the backbones of these thermoset monomers. Amide-extended acrylate and methacrylate monomers can also be prepared.Type: ApplicationFiled: August 13, 2009Publication date: June 23, 2011Applicant: DESIGNER MOLECULES, INC.Inventor: Stephen M. Dershem
-
Patent number: 7964687Abstract: An oxylamino group-containing compound represented by the following formula: R1—B-A-B—R2, wherein R1 represents a polymerizable group, R2 represents an oxylamino group-containing group or an oxylamino derivative-containing group, B represents an ester linkage or an amide linkage, and A represents an optionally substituted alkylene group having 2 to 12 carbon atoms.Type: GrantFiled: July 7, 2005Date of Patent: June 21, 2011Assignees: Sumitomo Bakelite Company, Ltd., National University Corporation Hokkaido UniversityInventors: Shinichiro Nishimura, Hideyuki Shimaoka
-
Patent number: 7947151Abstract: A paper softening composition that is capable of providing paper with excellent flexibility while suppressing decrease in paper strength. The paper softening composition contains a specific diamide diamine compound or a salt thereof and a specific amide amine compound or a salt thereof in a mass ratio of 5/95 to 90/10.Type: GrantFiled: February 15, 2007Date of Patent: May 24, 2011Assignee: NOF CorporationInventors: Tetsuya Tamai, Kazumichi Asakura, Yasuyuki Nakamura, Takashi Matsufuji
-
Patent number: 7943799Abstract: It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group and * represents an asymmetric center, a method for producing it and a method for producing an optically active cycloalkylidenebisoxazoline compound represented by the formula (4): wherein R1, R2 and * are as defined above, using thereof.Type: GrantFiled: October 20, 2010Date of Patent: May 17, 2011Assignee: Sumitomo Chemical Company, LimitedInventor: Makoto Itagaki
-
Patent number: 7932303Abstract: A material contains at least a polymerizable N,O-functionalized acrylic acid hydroxyamide of the Formula (I) in which A is an n+m-valent linear or branched aliphatic C1 to C50 radical, in which the carbon chain can be interrupted by O, S, —CO—O—, CO—NH, O—CO—NH or NH—CO—NH, an n+m-valent aromatic C6 to C18 radical or an n+m-valent cycloaliphatic or heterocyclic C3 to C18 radical, wherein the radicals can carry one or more substituents, Y is not present, or is O, S, an ester, amide or urethane group, R1 is hydrogen, an aliphatic C1 to C20 alkyl or C3 to C8 cycloalkyl radical which can carry one or more substituents, R2 is H or a C1 to C10 alkyl radical, R3 is not present or is a C1 to C16 alkylene radical which can be interrupted by O, HG is not present, is —COOH, —P?O(OH)2; —P?O(OH)(OR4); —O—P?O(OH)2, —SO2OH or —O—P?O(OH)(OR4), R4 is a C1 to C15 alkyl radical, phenyl or benzyl radical and n is a number from 1 to 5 and m a number from 0 to 3.Type: GrantFiled: September 11, 2007Date of Patent: April 26, 2011Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Iris Lamparth, Urs Karl Fischer, Frank Zeuner, Armin de Meijere, Volker M. Rheinberger
-
Publication number: 20110092601Abstract: Polyamine, polyamine/guanidino, and polyamine/biguanide compounds bearing allene, propargyl, cyclopropyl, and other reactive moieties are disclosed. The compounds are useful as irreversible inhibitors of the enzyme lysine-specific demethylase-1 and for the treatment of cancer.Type: ApplicationFiled: April 14, 2008Publication date: April 21, 2011Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Patrick M. Woster, Robert A. Casero
-
Patent number: 7923576Abstract: The invention relates to tuned multifunctional linker molecules for charge transport through organic-inorganic composite structures. The problem underlying the present invention is to provide multifunctional linker molecules for tuning the conductivity in nanoparticle-linker assemblies which can be used in the formation of electronic networks and circuits and thin films of nanoparticles. The problem is solved according to the invention by providing a multifunctional linker molecule of the general structure CON1-FUNC1-X-FUNC2-CON2 in which X is the central body of the molecule, FUNC1 and FUNC2 independently of each other are molecular groups introducing a dipole moment and/or capable of forming intermolecular and/or intramolecular hydrogen bonding networks, and CON1 and CON2 independently of each other are molecular groups binding to nanostructured units comprising metal and semiconductor materials.Type: GrantFiled: January 3, 2006Date of Patent: April 12, 2011Assignee: Sony Deutschland GmbHInventors: Jurina Wessels, William Ford, Akio Yasuda
-
Patent number: 7915450Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds lo prepare liposomes and other lipid aggregates suitable for iransfcclion or delivery of compounds to target cells, cither in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules. particularly polyanions such as nucleic acids. These compounds have the properly, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.Type: GrantFiled: December 15, 2009Date of Patent: March 29, 2011Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Publication number: 20110065850Abstract: Disclosed herein are ink compositions including an ink vehicle and a colorant, wherein the ink vehicle comprises a compound having a formula of: R1—CONH—R6—CONH—R3, R1—NHCO—R6—CONH—R3, R1—CONH—R6—NHCO—R3, R1—NHCO—R6—NHCO—R3, R1—CONH—R6—CONH—C36H64+n—CONH—R6—CONH—R3, R1—NHCO—R6—NHCO—C36H64+n—NHCO—R6—NHCO—R3, R1—CONH—R6—NHCO—C36H64+n—CONH—R6—NHCO—R3, R1—NHCO—R6—CONH—C36H64+n—NHCO—R6—CONH—R3, R1—CONH—R4—CONH—C36H64+n—CONH—R5—CONH—R3, R1—CONH—R4—NHCO—C36H64+n—CONH—R5—NHCO—R3, R1—NHCO—R4—CONH—C36H64+n—NHCO—R5—CONH—R3, R1—NHCO—R4—NHCO—C36H64+n—CONH—R5—CONH—R3, or R1—CONH—R4—CONH—C36H64+n—NHCO—R5—NHCO—R3, wherein n is an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, R6 is a cyclic group having from 5 to 8 carbon atoms, R1 and R3 each comprise a branched alkyl group derived from isostearic acid, and R4 and R5 are the same or different and comprise an alkylene having from 1 to about 200 carbon atoms orType: ApplicationFiled: November 17, 2010Publication date: March 17, 2011Applicant: Xerox CorporationInventors: Jeffrey H. BANNING, Stephan V. Drappel, Michael B. Meinhardt, Randall R. Bridgeman, Alex J. Kugel
-
Publication number: 20110060081Abstract: Disclosed herein are compounds having a formula of: R1—CONH—R6—CONH—C36H64+n—CONH—R6—CONH—R3, R1—NHCO—R6—NHCO—C36H64+n—NHCO—R6—NHCO—R3, R1—CONH—R6—NHCO—C36H64+n—CONH—R6—NHCO—R3, R1—NHCO—R6—CONH—C36H64+n—NHCO—R6—CONH—R3, R1—CONH—R4—CONH—C36H64+n—CONH—R5—CONH—R3, R1—CONH—R4—NHCO—C36H64+n—CONH—R5—NHCO—R3, R1—NHCO—R4—CONH—C36H64+n—NHCO—R5—CONH—R3, R1—NHCO—R4—NHCO—C36H64+n—CONH—R5—CONH—R3, or R1—CONH—R4—CONH—C36H64+n—NHCO—R5—NHCO—R3, wherein n is an integer of 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, R6 is the same or different cyclic group having from 5 to 8 carbon atoms, R4 and R5 are the same or different and comprise an alkylene having from 1 to about 200 carbon atoms, and R1 and R3 are the same or different and comprise a straight chain or branched alkyl group having from about 3 carbon atoms to about 200 carbon atoms and one or both of R1 and R3 include at least one hydroxyl group substituent, and ink compositions including the compounds as an ink vehicle.Type: ApplicationFiled: November 17, 2010Publication date: March 10, 2011Applicant: XEROX CORPORATIONInventors: Jeffrey H. Banning, Stephan V. Drappel, Michael B. Meinhardt, Randall R. Bridgeman, Alex J. Kugel
-
Publication number: 20110046415Abstract: It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group and * represents an asymmetric center, a method for producing it and a method for producing an optically active cycloalkylidenebisoxazoline compound represented by the formula (4): wherein R1, R2 and * are as defined above, using thereof.Type: ApplicationFiled: October 20, 2010Publication date: February 24, 2011Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Makoto ITAGAKI
-
Patent number: 7875268Abstract: The present disclosure relates to specific dimercaptoamides, reducing compositions for permanently reshaping keratin fibers comprising the dimercaptoamides, for instance, human keratin fibers such as the hair; and processes for reshaping keratin fibers comprising the application of said reducing compositions. The present disclosure also relates to processes for preparing the dimercaptoamides.Type: GrantFiled: April 6, 2005Date of Patent: January 25, 2011Assignee: L'Oreal S.A.Inventors: Michel Philippe, Gérard Malle, Christian Blaise
-
Patent number: 7842839Abstract: It is provided to an optically active cycloalkylidenebisamidoalcohol compound represented by the formula (3): wherein R1 represents a C1-6 alkyl group, an optionally substituted phenyl group, an optionally substituted aralkyl group or a hydrogen atom, or two R1s, which are bonded to the same carbon atom, are bonded to form a ring together with the carbon atom to which they are bonded, R2 represents a C1-6 alkyl group, an optionally substituted aralkyl group or an optionally substituted phenyl group and * represents an asymmetric center, a method for producing it and a method for producing an optically active cycloalkylidenebisoxazoline compound represented by the formula (4): wherein R1, R2 and * are as defined above, using thereof.Type: GrantFiled: December 21, 2004Date of Patent: November 30, 2010Assignee: Sumitomo Chemical Company, LimitedInventor: Makoto Itagaki
-
Patent number: 7790926Abstract: Alpha, omega-difunctional aldaramides, in particular diaminoaldaramides, dihydroxyaldaramides, bis(alkoxycarbonylalkyl)aldaramides, and bis(carboxyalkyl)aldaramides, and processes for preparing the aldaramides are provided.Type: GrantFiled: January 31, 2008Date of Patent: September 7, 2010Assignee: E. I. du Pont de Nemours and CompanyInventors: Mark Allen Andrews, Henry Keith Chenault, Garret D. Figuly
-
Patent number: 7786332Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling, subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.Type: GrantFiled: August 8, 2008Date of Patent: August 31, 2010Assignee: Merck Patent GmbHInventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
-
Patent number: 7786321Abstract: The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin ageing caused by decrease of skin elasticity and/or by collagen degradation in the structure for tissues.Type: GrantFiled: August 4, 2008Date of Patent: August 31, 2010Assignee: L'Oreal S.A.Inventors: Maria Dalko, Yann Mahe, Lionel Breton
-
Patent number: 7759377Abstract: Compounds of formula (I) as defined herein: inhibit the formation of the ?-amyloid peptide (?-A4) and are, therefore, useful in the treatment of pathologies in which a ?-amyloid peptide (?-A4) formation inhibitor provides a therapeutic benefit. Particular such pathologies are senile dementia, Alzheimer's disease, Down's syndrome, Parkinson's disease, amyloid angiopathy, cerebrovascular disorders, frontotemporal dementias and Pick's disease, post-traumatic dementias, pathologies linked to neuroinflammatory processes, Huntington's disease and Korsakov's syndrome.Type: GrantFiled: March 20, 2008Date of Patent: July 20, 2010Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Marc Pascal, Viviane Van Dorsselaer
-
Patent number: 7754898Abstract: An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH?N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.Type: GrantFiled: January 24, 2005Date of Patent: July 13, 2010Assignee: Japan Science and Technology AgencyInventor: Shu Kobayashi
-
Patent number: 7750044Abstract: The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an alkanolamine to make an ester quaternary compound. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications. These materials are dimethylaminopropyl amine free, which is highly desirable in personal care applications.Type: GrantFiled: April 1, 2008Date of Patent: July 6, 2010Assignee: SurfaTech CorporationInventors: Kevin A. O'Lenick, Anthony J. O'Lenick, Jr.
-
Publication number: 20100152254Abstract: Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided.Type: ApplicationFiled: February 19, 2008Publication date: June 17, 2010Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventors: Meir Bialer, Boris Yagen, Neta Pessah
-
Patent number: 7714167Abstract: The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxidation employs a catalyst system composed of a metal and a chiral bishydroxamic acid ligand, which, in the presence of a stoichiometric oxidation reagent, serves to asymmetrically oxidize a variety of substrates.Type: GrantFiled: January 22, 2007Date of Patent: May 11, 2010Assignees: University of Chicago, Japan Science & Technology AgencyInventors: Hisashi Yamamoto, Arindrajit Basak, Wei Zhang
-
Publication number: 20100093867Abstract: An object of the present invention is to provide compounds having read-through activity for use in treatment methods of genetic diseases caused by nonsense mutation, to provide pharmaceutical compositions comprising the compound, and to provide a treatment method of genetic diseases caused by nonsense mutation comprising administering the compound. The present invention can provide a method of producing wild type normal protein in a living body of a mammal from a gene with a premature termination codon being generated by a mutation, wherein the method comprises administering a compound expressed by the following formula (VI): (wherein R1, R2, R3, R4, R5 and X1 in the formula are as defined in description) or the like to the mammal.Type: ApplicationFiled: July 5, 2007Publication date: April 15, 2010Inventors: Ryoichi Matsuda, Masataka Shiozuka, Alexander MacKerell, JR.
-
Patent number: 7696380Abstract: Disclosed are a mixture of at least two amide-based compounds represented by General Formula (1): wherein a represents an integer of 2 to 6, R1 represents a C2-30 saturated or unsaturated aliphatic polycarboxylic acid residue, and the aliphatic polycarboxylic acid has a valency of 2 to 6, and two to six R2 groups are the same or different, and each represent a trans-2-alkylcyclohexylamine residue or a cis-2-alkylcyclohexylamine residue, the mixture having a content of a trans-2-alkylcyclohexylamine residue of at least 70 mole % but less than 100 mole % of the total 2-alkylcyclohexylamine residues in the mixture, or an all-trans amide-based compound wherein all of the 2 to 6 R2 groups represent a trans-2-alkylcyclohexylamine residue; a polyolefin resin nucleating agent comprising the mixture or the all-trans amide-based compound; a polyolefin resin composition containing the amide-based compound or the mixture; a molded article obtainable by molding the composition.Type: GrantFiled: October 8, 2004Date of Patent: April 13, 2010Assignee: New Japan Chemical Co., Ltd.Inventors: Hiroshi Kitagawa, Masahide Ishikawa, Chiaki Ueoka, Sukehiro Niga, Yohei Uchiyama
-
Patent number: 7662999Abstract: Small molecule polycationic agents are used to modulate or interrupt biological processes by binding to oligosaccharide-based biomolecules. Compounds that inhibit nitric oxide, TNF? or other immunomodulators are provided and are useful for treating immunological disease and disease of an infectious disorder.Type: GrantFiled: March 30, 2007Date of Patent: February 16, 2010Assignees: National Institutes of Health (NIH), The United States of America as represented by the Department of Health and Human Services (DHHS)Inventors: Mark R. Burns, Sunil A. David
-
Patent number: 7572790Abstract: Compound of formula (I): or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.Type: GrantFiled: April 7, 2004Date of Patent: August 11, 2009Assignee: SmithKline Beecham CorporationInventors: Nicola Mary Aston, Paul Bamborough, Katherine Louise Jones, Vipulkumar Kantibhai Patel, Stephen Swanson, Ann Louise Walker
-
Patent number: 7569706Abstract: (wherein R represents a residue comprising a reactive group or a group capable of being transformed into the reactive group; n represents an integer of 3 or more; and X represents a residue capable of having the following structure by n in number: R1s each represent a hydrogen atom or a group capable of being transformed into a hydrogen atom, and 6 or more of R1s may be the same or different) The compound represented by the above formula (1), which is capable of modifying a physiologically active polypeptide or a derivative thereof, or a low molecular compound while maintaining the physiological activity, or which is useful for improving the stability or water-solubility of the low molecular compound, are provided.Type: GrantFiled: September 2, 2003Date of Patent: August 4, 2009Assignees: Kyowa Hakko Kirin Co., Ltd., Tecno Network Shikoku Co., Ltd.Inventors: Hisao Nemoto, Motoo Yamasaki, Toshiyuki Suzawa, Hiroyuki Yamaguchi
-
Publication number: 20090131674Abstract: The present invention relates to polyamide oligomers with linear or branched chain structure with a number average molar mass of 800 to 5000 g/mol, with basic end groups which are at least partially NH2 end groups and carboxyl end groups, produced by condensation of polyamide-forming monomers, the concentration of NH2 end groups being at most 300 mmol/kg and in that these end groups are present in excess in a ratio to the carboxyl end groups.Type: ApplicationFiled: April 24, 2006Publication date: May 21, 2009Inventors: Eduard Schmid, Botho Hoffmann
-
Publication number: 20090111834Abstract: The present invention relates to the discovery that certain non-naturally occurring, non-peptide amide compounds and amide derivatives, such as oxalamides, ureas, and acrylamides, are useful flavor or taste modifiers, such as a flavoring or flavoring agents and flavor or taste enhancer, more particularly, savory (the “umami” taste of monosodium glutamate) or sweet taste modifiers, —savory or sweet flavoring agents and savory or sweet flavor enhancers, for food, beverages, and other comestible or orally administered medicinal products or compositions.Type: ApplicationFiled: October 23, 2008Publication date: April 30, 2009Inventors: Catherine Tachdjian, Andrew P. Patron, Sara L. Adamski-Werner, Farid Bakir, Qing Chen, Vincent Darmohusodo, Stephen Terrence Hobson, Xiaodong Li, Ming Qi, Daniel Harry Rogers, Marketa Rinnova, Guy Servant, Xiao-Qing Tang, Mark Zoller, David Wallace, Amy Xing, Klaus Gubernator
-
Patent number: 7511077Abstract: Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain.Type: GrantFiled: February 8, 2006Date of Patent: March 31, 2009Assignee: Neuromed Pharmaceuticals Ltd.Inventors: Hassan Pajouhesh, Hossein Pajouhesh, Yanbing Ding, Terrance P. Snutch, Francesco Belardetti
-
Publication number: 20090076115Abstract: The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.Type: ApplicationFiled: February 28, 2006Publication date: March 19, 2009Applicants: The General Hospital Corporation, Lynntech, Inc.Inventors: Tim Wharton, Hariprasad Gali, Michael R. Hamblin
-
Publication number: 20090048226Abstract: The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1? converting enzyme (“ICE”) inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1-(“IL-1”), apoptosis-, interferon-? inducing factor-(IGIF), or interferon-?-(“IFN-?”) mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-? production and methods for treating interleukin-1, apoptosis-, and interferon-?-mediated diseases using the compounds and compositions of this invention.Type: ApplicationFiled: January 22, 2008Publication date: February 19, 2009Inventors: Marion W. Wannamaker, Guy W. Bemis, Paul S. Charifson, David J. Lauffer, Michael D. Mullican, Mark A. Murcko, Keith P. Wilson, James W. Janetka, Robert J. Davies, Anne-Laure Grillot, Zhan Shi, Cornelia J. Forster
-
Patent number: 7491817Abstract: Universal supports for oligonucleotide synthesis include a support material represented by the following formula: In this formula, substituent A is selected from H, alkyl, aryl, or a polymeric or silica base material; substituent B is selected from acyl, aroyl, or a polymeric or silica base material; and substituent C is selected from a dimethoxytrityl group or a protecting group removable under acidic or neutral conditions. For the supports, one of substituents A or B constitutes the polymeric or silica base material. In use, an oligonucleotide is attached to the support at substituent C.Type: GrantFiled: May 24, 2004Date of Patent: February 17, 2009Assignee: Glen Research CorporationInventors: Alex Azhayev, Maxim Antopolskii
-
Patent number: 7488848Abstract: The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.Type: GrantFiled: March 17, 2006Date of Patent: February 10, 2009Assignee: Virobay, Inc.Inventors: Michael Graupe, John O. Link, Michael G. Roepel
-
Publication number: 20090030232Abstract: The present invention is directed to the labeled compounds, wherein C* is each either 13C and 12C where at least one C* is 13C, each hydrogen of the methylene group is hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is sulfide, sulfinyl, or sulfone, Z is an aryl group such as 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, or a phenyl group wherein R1, R2, R3, R4 and R5 are each independently either hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group such as NH2, NHR and NRR? where R and R? are each independently either a C1-C4 lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.Type: ApplicationFiled: July 22, 2008Publication date: January 29, 2009Inventors: Rodolfo A. Martinez, Clifford J. Unkefer, Marc A. Alvarez
-
Publication number: 20090018143Abstract: The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, X, Y, R1, R2, R3, and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder (“ADHD”), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.Type: ApplicationFiled: November 8, 2007Publication date: January 15, 2009Applicants: Cephalon, Inc., Cephalon FranceInventors: Brigitte Lesur, Philippe Louvet, Rabindranath Tripathy
-
Patent number: 7442558Abstract: The present invention provides luminescent lanthanide metal chelates comprising a metal ion of the lanthanide series and a complexing agent comprising at least one phthalamidyl moiety. Also provided are probes incorporating the phthalamidyl ligands of the invention and methods utilizing the ligands of the invention and probes comprising the ligands of the invention.Type: GrantFiled: June 14, 2004Date of Patent: October 28, 2008Assignee: The Regents of the University of CaliforniaInventors: Kenneth N. Raymond, Stephane Petoud, Seth Cohen, Jide Xu
-
Patent number: RE43327Abstract: The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.Type: GrantFiled: January 8, 2002Date of Patent: April 24, 2012Assignee: Aminex Therapeutics, Inc.Inventors: Mark R. Burns, Gerard F. Graminski, Nand Baindur