Two Carboxamido Carbonyls Having No Carboxamido Nitrogen Between The Carbonyls Patents (Class 564/160)
  • Patent number: 5420324
    Abstract: Fumaramide-containing monomers are disclosed which are especially useful in the preparation of biocompatible devices, especially contact lenses.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: May 30, 1995
    Assignee: Bausch & Lomb Incorporated
    Inventors: Yu-Chin Lai, Ronald E. Bambury
  • Patent number: 5419894
    Abstract: Compounds of the general formula I: ##STR1## wherein R.sup.1 signifies a COOX group or the group ##STR2## R.sup.2 and R.sup.3 are the same or different and signify a hydrogen atom, a lower straight- or branched-chain, hydrocarbon radical, a phenyl or benzyl group or either R.sup.2 or R.sup.3 signifies the group ##STR3## or R.sup.2 or R.sup.3 together signify a trimethylene or tetramethylene radical, R.sup.4 represents a straight- or branched-chain mono- or poly-hydroxyalkyl radical, R.sup.5 represents a hydrocarbon atom, a lower straight- or branched-chain, optionally mono- or poly-hydroxylated, hydrocarbon radical, Q signifies an oxygen or sulfur atom or the group ##STR4## and X represents hydrogen atoms and/or metal ion equivalents, and their salts with physiologically harmless organic bases, are valuable complexing agents, complexes and complex salts for diagnostic imaging.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: May 30, 1995
    Assignee: Schering Aktiengesellschaft
    Inventors: Heinz Gries, Franz-Josef Renneke, Hanns-Joachim Weinmann
  • Patent number: 5411989
    Abstract: The invention concerns nitric acid esters of cyclohexanol of formula I ##STR1## in which A signifies a valency bond or a C.sub.1 -C.sub.6 -alkylene chain and B the group --NR.sup.1 --CO--Z, --NR.sup.1 --SO.sub.2 --Z or --CO--NR.sup.2 --Z, whereby R.sup.1 signifies hydrogen or a C.sub.1 -C.sub.6 -alkyl alkyl group R.sup.2 hydrogen, a hydroxyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.2 -C.sub.6 -alkynyl group and Z signifies hydrogen a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.2 -C.sub.6 -alkynyl group which may optionally be substituted for the case that B is an --NR.sup.1 --CO--Z group, Z can also signify a C.sub.1 -C.sub.6 -alkoxy group.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: May 2, 1995
    Assignee: Boehringer Mannheim, GmbH
    Inventors: Helmut Michel, Wolfgang Bartsch
  • Patent number: 5405987
    Abstract: The present invention pertains to a method of preparing substituted and unsubstituted N-hydroxy-2-aminobutane diacid derivatives which can be dehydrated to 2-aminobut-2-ene dioic acid derivatives, which can be subsequently converted to pyridine and quinoline derivatives.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: April 11, 1995
    Assignee: Hoechst Celanese Corporation
    Inventors: Varadaraj Elango, Donald R. Larkin, John R. Fritch, Michael P. Bodman, Werner H. Mueller, Bernard F. Gupton, John C. Saukaitis
  • Patent number: 5405936
    Abstract: Liquid-melt aliphatic dicarboxylic acids tend to undergo undesirable discoloration during prolonged storage. The discoloration can be avoided by an addition of 0.1 to 3.0% by weight of a primary amine.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: April 11, 1995
    Assignee: Huels Aktiengesellschaft
    Inventors: Salih Mumcu, Franz-Erich Baumann
  • Patent number: 5397489
    Abstract: A lubricating oil soluble compound suitable for use as a dispersant additive is obtainable by reacting at elevated temperature a polyacrylate with a dispersant having at least one reactive nitrogen--containing moiety.Intermediates of the general formula IV ##STR1## where Y.sup.1 is a group derived from the reaction of the polyacrylate with the reactive nitrogen-containing moieties (i.e. primary or secondary amine) are novel.The process for preparing the lubricating oil soluble compounds can be a one step or multistep process.Lubricating oil compositions comprise a major proportion of lubricating oil and a minor proportion of the lubricating oil soluble compounds.
    Type: Grant
    Filed: October 26, 1992
    Date of Patent: March 14, 1995
    Assignee: BP Chemicals (Additives) Limited
    Inventor: William D. Carlisle
  • Patent number: 5395971
    Abstract: A process for making unsaturated .alpha.-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general formula LL'MoO.sub.2, L.sub.2 L'MoO.sub.2, or LL'MoO(X--Y).
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: March 7, 1995
    Assignee: The Board of Regents of The University of Oklahoma
    Inventors: Kenneth M. Nicholas, Anurag S. Srivastava
  • Patent number: 5393319
    Abstract: Oxamide granules are produced by (A) feed-mixing ammonia to a starting material comprising 60 to 100 weight % of a diester of oxalic acid with a C.sub.1-6 aliphatic alcohol, and 0 to 40 weight % of the same aliphatic alcohol as mentioned above, to produce oxamide and the aliphatic alcohol as by-product, while controlling the aliphatic alcohol content to 5 to 40% based on the weight of the reaction mixture to provide the resultant oxamide wetted by the aliphatic alcohol; (B) granulating the wetted product while maintaining the content of the aliphatic alcohol at a level of 5 to 40% based on the weight of the wetted reaction product; (C) heat-evaporating away the aliphatic alcohol from the wetted granules; and optionally (D) re-wetting the resultant dry oxamide granules with water in an amount of 5 to 20% based on the weight of the dry oxamide granules; and (E) re-drying the re-wetted oxamide granules, to provide oxamide granules having an enhanced mechanical strength and form-stability in water.
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: February 28, 1995
    Assignee: Ube Industries, Ltd.
    Inventors: Yukio Inaba, Tomohiko Yamamoto, Genji Koga, Hideki Noguchi, Joji Funatsu
  • Patent number: 5391811
    Abstract: .alpha.-fluoro-.beta.-dicarbonyl compounds are prepared by reacting a halogenated dicarbonyl compound at temperatures of 20.degree. to 100.degree. C. with an addition product of hydrogen fluoride and a trialkylamine. This process is easy to carry out in technical terms and can also be carried out on a large scale.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: February 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Stefan Bohm, Albrecht Marhold
  • Patent number: 5391826
    Abstract: Diamidopolyamines are prepared by reacting glutamic acid with two moles, per mole of glutamic acid, of a defined class of diamines, including oxyethyelene diamines, oxypropylenediamines, oxyethylene/propylene diamines, oxypropylene triamines, 1,2-diaminocyclohexane and isophorone diamine, whereby each of the carboxyl groups of the glutamic acid will react with an amine group of the amine reactant to thereby provide primary amine terminated amidopolyamines containing, internally, the unreacted primary amine group of the glutamic acid.
    Type: Grant
    Filed: May 4, 1990
    Date of Patent: February 21, 1995
    Assignee: Huntsman Corporation
    Inventors: George P. Speranza, Jiang-Jen Lin
  • Patent number: 5380873
    Abstract: A coupling agent useful in conducting immunoassays, particularly assays for B12, is disclosed. The coupling agent has the formula ##STR1## Z and Z' can be the same or different and each is ##STR2## k, m and n are integers from 1 to 10, X is an alkylene group, a cycloalkylene group, an alkylcycloalkylene group, a bivalent aromatic group, or an aminoalkylene group, R and R' can be the same or different, and each is a substituted or unsubstituted aminoalkylene group having from 1 to 10 carbon atoms or a cycloalkylene or alkylcycloalkylene group having from 5 to 20 carbon atoms. Z and Z' are the same except that they can be the same or different when both are ##STR3## A method for purifying an aqueous intrinsic factor solution which contains R-protein is disclosed.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 10, 1995
    Assignee: Abbott Laboratories
    Inventors: Christopher Bieniarz, Christopher Welch
  • Patent number: 5369108
    Abstract: The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: November 29, 1994
    Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia
    Inventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic
  • Patent number: 5349109
    Abstract: A process for making unsaturated .alpha.-amines from olefins wherein the process includes adding an aminating agent, an olefin and a molybdenum based catalyst to a reaction vessel having a nitrogen atmosphere. The catalyst may be described by the general formula LL'MoO.sub.2, L.sub.2 L'MoO.sub.2, or LL'MoO(X-Y).
    Type: Grant
    Filed: August 26, 1993
    Date of Patent: September 20, 1994
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Kenneth M. Nicholas, Anurag S. Srivastava
  • Patent number: 5312617
    Abstract: Novel complexes of paramagnetic ions and compounds bearing long acyl chains have been synthesized as magnetic resonance imaging contrast agents. These novel liposoluble contrast agents may be administered alone, or with lipids, suspending agents or other additives. The lipids may be in the form of liposomes, micelles or lipid emulsions. The contrast agents of the invention have particular use in magnetic resonance imaging of the liver, blood pool and reticuloendothelial system.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: May 17, 1994
    Inventors: Evan C. Unger, DeKang Shen
  • Patent number: 5306844
    Abstract: A d- or l-tartaric acid amide derivative serving as a host compound and a method of producing the amide derivative which combines with a guest compound to form a clathrate compound and which is expressed by the following Formula (A) or (B): ##STR1##
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: April 26, 1994
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Fumio Toda, Koichi Tanaka
  • Patent number: 5300584
    Abstract: A low viscosity, diprimary amine-terminated reactive liquid polymer with low residual amine content, comprising the reaction product of a diprimary amine having the following formulaH.sub.2 N--R--NH.sub.2wherein --NH.sub.2 is a primary terminal amine group; andwherein R is(1) a C.sub.4 -C.sub.12 aliphatic chain having alkyl branches containing 2 to 4 carbons, wherein the positions of said alkyl branches within the C.sub.4 -C.sub.12 aliphatic chain are such that they impart relatively different rates of reactivity to the terminal primary amine groups; or(2) a carbon to carbon backbone containing at least one non-reactive heteroatom, comprising(a) a C.sub.2 -C.sub.20 aliphatic or cycloaliphatic moiety containing at least one tertiary amine; or(b) a polyoxyalkylene wherein the alkyl portion of said polyoxyalkylene contains 2 to 4 carbon atoms;and a functional-terminated reactive liquid polymer useful as an epoxy resin modifier employed with a curing agent.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: April 5, 1994
    Assignee: The B. F. Goodrich Company
    Inventor: Julius Farkas
  • Patent number: 5292924
    Abstract: .alpha.-Fluoro-substituted N-acryloylamino acid derivatives of the formula ##STR1## are used to make polymers optionally for chromatographic resolution of racemates into their enantiomers. The fluorine atom improves performance in many instances.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: March 8, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Rolf Grosser, Walter Lange, Bruno Bomer, Dieter Arlt, Dietmar Bielefeldt
  • Patent number: 5286899
    Abstract: An efficient and commercially-viable method for the stereoselective transformation of a diol to an alcohol is disclosed. The present method is particularly well-suited for the preparation of the unnatural D-isomer of malic acid or its derivatives from the abundant naturally occurring L-tartaric acid or derivatives thereof.
    Type: Grant
    Filed: August 27, 1992
    Date of Patent: February 15, 1994
    Assignee: Sepracor, Inc.
    Inventor: Yun Gao
  • Patent number: 5274062
    Abstract: A polymer comprising a carbon-carbon backbone chain and at least one N-(substituted oxalyl)carbamoyl group of the formula: --CO--NH--CO--CO--OR wherein R is a hydrocarbon group as a side chain attached to said backbone chain.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: December 28, 1993
    Assignee: Nippon Paint Co., Ltd.
    Inventors: Yuji Suzuki, Satoshi Urano, Hirotoshi Umemoto, Ryuzo Mizuguchi, Kei Aoki, Noriyuki Tsuboniwa
  • Patent number: 5274051
    Abstract: Novel carbonyl containing compositions are prepared by contacting, in the presence of a free radical initiator, a first compound selected from the group consisting of saturated hydrocarbons, substituted saturated hydrocarbons, polymers and mixtures thereof with a carbonyl containing compound or mixtures thereof having the structure: ##STR1## where X and Y are independently selected from OH, OR.sub.1, NR.sub.1 R.sub.2 and R.sub.1 wherein R.sub.1 and R.sub.2 are selected independently from the group consisting of aryl radicals or alkyl radicals of from 1 to 18 carbon atoms.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: December 28, 1993
    Assignee: Exxon Research & Engineering Company
    Inventors: Stanley J. Brois, Jacqueline Ogletree
  • Patent number: 5247125
    Abstract: Novel thiol-terminated hydroxyamides, and processes for their preparation and use are provided. These hydroxyamide compounds may be prepared by the reaction of a mercapto-functional alkyl ester, such as methylmercaptopropionate, with a molar excess of an alcohol-substituted amine, such as a b-hydroxyalkyl amine. The thiol-terminated hydroxyamides are useful as polymerization chain transfer agents, particularly when it is desirable to form polymers or oligomers containing functional hydroxyamide end groups. By chain terminating such polymers or oligomers with reactive hydroxyamide end groups the polymers or oligomers can be further reacted with acid-containing monomers or polymers to form block or graft copolymers.
    Type: Grant
    Filed: February 28, 1991
    Date of Patent: September 21, 1993
    Assignee: Rohm and Haas Company
    Inventors: Andrew W. Gross, William D. Emmons
  • Patent number: 5217634
    Abstract: A material useful as a dispersant additive in oleaginous compositions selected from fuels and lubricating oils comprising the reaction products of:(i) at least one intermediate adduct comprised of the reaction products of(a) at least one polyepoxide, and(b) at least one member selected from the group consisting of polyamines, polyols, and amino alcohols; and(ii) at least one of (a) hydrocarbyl substituted C.sub.3 -C.sub.10 monocarboxylic or C.sub.4 -C.sub.10 dicarboxylic acid producing material; (b) an aldehyde and a hydrocarbyl substituted hydroxy aromatic compound; or (c) an aldehyde and the reaction product of a hydrocarbyl substituted C.sub.3 -C.sub.10 monocarboxylic or C.sub.4 -C.sub.10 dicarboxylic acid or anhydride and an amine substituted hydroxy aromatic compound.Also included is a process for preparing said material and an oleaginous composition containing said material.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: June 8, 1993
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Jacob Emert, Antonio Gutierrez, Robert D. Lundberg
  • Patent number: 5189200
    Abstract: An efficient and commerically-viable method for the stereoselective transformation of a diol to an alcohol is disclosed. The present method is particularly well-suited for the preparation of the unnatural D-isomer of malic acid or its derivatives from the abundant naturally occurring L-tartaric acid or derivatives thereof.
    Type: Grant
    Filed: December 21, 1990
    Date of Patent: February 23, 1993
    Assignee: Sepracor, Inc.
    Inventor: Yun Gao
  • Patent number: 5169975
    Abstract: Binary azulenesquaric acid dyes of the formula ##STR1## where X is a bridging member, Y is hydrogen, cyano or formula CO--OR.sup.5, CO--NHR.sup.5, OR.sup.5, O--CO--OR.sup.5, NH--CO--R.sup.5, NH--CO--OR.sup.5 or NH--SO.sub.2 --R.sup.5, where R.sup.5 is hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.12 -alkenyl, C.sub.5 -C.sub.7 -cycloalkyl or unsubstituted or substituted phenyl, L.sup.1 and L.sup.2 are each, independently of one another, a chemical bond or unsubstituted or substituted C.sub.1 -C.sub.12 -alkylene and R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q.sup.1, Q.sup.2, Q.sup.3 and Q.sup.4 are each, independently of one another, hydrogen or unsubstituted or substituted C.sub.1 -C.sub.12 -alkyl, their intermediates and an optical recording medium containing the novel dyes are described.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: December 8, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Schmitt, Bernhard Albert, Sibylle Brosius, Klaus D. Schomann, Harald Kuppelmaier
  • Patent number: 5139706
    Abstract: Surfactant composition prepared by reacting dicarboxylic acids and esters thereof, such as adipic acid, diethyl oxalate, etc.; a polyoxyalkyleneamine residue, such as an alkylene glycol diamine bottoms product, and fatty acids and esters thereof, such as tallow acid or coconut acid, are described. These nonionic surfactant compositions are useful for preparing surfactant bars, or other molded or shaped articles such as toys.
    Type: Grant
    Filed: February 12, 1991
    Date of Patent: August 18, 1992
    Assignee: Texaco Chemical Company
    Inventors: George P. Speranza, Wei-Yang Su
  • Patent number: 5117058
    Abstract: Novel cationic amide compositions having the structure ##STR1## where R.sup.1 represents an alkylene group of the formula C.sub.n H.sub.2n, and alkenyl group of the formula C.sub.n H.sub.n, or a phenyl group, or mixtures thereof, where n equals 0 to 10; R.sup.2 represents C.sub.m H.sub.2m, where m equals 1 to 4; R.sup.3 independently represents methyl, ethyl or propyl; and the combination of R.sup.4 and X.sup.- represents the remnant from a quaternizing agent have been discovered and have been found useful as demulsifiers in breaking petroleum emulsions as might be produced during fireflooding petroleum recovery procedures. In one embodiment, the cationic amide/ester compositions are made by reacting (1) a dicarboxylic acid of the formula: ##STR2## where R.sup.1 represents C.sub.n H.sub.
    Type: Grant
    Filed: November 9, 1990
    Date of Patent: May 26, 1992
    Assignee: Baker Hughes Incorporated
    Inventors: Robert G. Chen, Adelina J. Son
  • Patent number: 5103056
    Abstract: Disclosed is a method for selective formation of amidoamines which comprises reacting a carboxylic acid group, such as, for example, a diacid or an aliphatic acid terminated amide with an aminopropylated disecondary amine which contains a secondary amine terminus in the same molecule at a temperature of about 150.degree. C. to about 260.degree.0 C.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: April 7, 1992
    Assignee: Texaco Chemical Company
    Inventors: George P. Speranza, Donald H. Champion
  • Patent number: 5101036
    Abstract: The invention relates to a process for the preparation of N-hydroxy-alpha-amino acids and the derivatives thereof by reacting a derivative of an alpha-amino acid with an aromatic aldehyde to form a Schiff base, oxidizing the Schiff base to an oxaziridine and converting the oxaziridine into the corresponding N-hydroxy-alpha-amino acid derivative and, if so desired, converting that derivative into the acid or a different derivative, in which an alpha-amino acid amide is used as starting material.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: March 31, 1992
    Assignee: Stamicarbon B.V.
    Inventors: Johan Kamphuis, Wilhelmus H. J. Boesten
  • Patent number: 5091573
    Abstract: Novel thiol-terminated hydroxyamides, and processes for their preparation and use are provided. These hydroxyamide compounds may be prepared by the reaction of a mercapto-functional alkyl ester, such as methylmercaptopropionate, with a molar excess of an alcohol-substituted amine, such as a .beta.-hydroxyalkyl amine. The thiol-terminated hydroxyamides are useful as polymerization chain transfer agents, particularly when it is desirable to form polymers or oligomers containing functional hydroxyamide end groups. By chain terminating such polymers or oligomers with reactive hydroxyamide end groups the polymers or oligomers can be further reacted with acid-containing monomers or polymers to form block or graft copolymers.
    Type: Grant
    Filed: August 27, 1990
    Date of Patent: February 25, 1992
    Assignee: Rohm and Haas Company
    Inventors: Andrew W. Gross, William D. Emmons
  • Patent number: 5072041
    Abstract: The invention relates to new pure D- or L-N-hydroxy-alpha-amino acids and the derivatives thereof, including optically active N-hydroxy-phenylglycine amide, which has antibiotic and antitumor activity.
    Type: Grant
    Filed: November 1, 1989
    Date of Patent: December 10, 1991
    Assignee: Stamicarbon B.V.
    Inventors: Johan Kamphuis, Wilhelmus H. J. Boesten
  • Patent number: 5068429
    Abstract: A method of removing copper from oxamide obtained through a process which involves the use of copper catalysts, by contacting it with an aqueous solution of a suitable complexing agent, which is capable of forming copper-containing water-soluble complexes and imparts to the aqueous solution a pH comprised between 2 and 8, optionally repeating the contacting step and, finally, recovering the purified oxamide by solid-liquid separation techniques.The claimed process affords oxamide containing less than 25 ppm of copper.
    Type: Grant
    Filed: October 24, 1989
    Date of Patent: November 26, 1991
    Assignee: Enichem Anic S.p.A.
    Inventors: Loreno Lorenzoni, Nino Dessantis, Angelo Virdis
  • Patent number: 5047587
    Abstract: A process is disclosed for the purification of the diamide of oxalic acid obtained by means a process wherein copper catalysts are used, by means of the washing with aqueous solutions of an ammonium salt of an organic or inorganic acid, operating at a pH value comprised within the range of from 2 to 8, and at a temperature comprised within the range of from 40.degree. to 150.degree. C.
    Type: Grant
    Filed: December 8, 1987
    Date of Patent: September 10, 1991
    Assignee: Enichem Anic S.p.A.
    Inventors: Loreno Lorenzoni, Giuseppe Messina, Vittorio Bruzzi
  • Patent number: 5047585
    Abstract: The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per liter solution.The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also uncoverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino-acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/liter solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20.degree.-60.degree. C.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: September 10, 1991
    Assignee: Stamicarbon B.V.
    Inventors: Wilhelmus H. J. Boesten, Hans E. Schoemaker, Bernardus H. N. Dassen
  • Patent number: 5041659
    Abstract: Disclosed is a method which comprises introducing into a reaction zone a feed which comprises a hydroxyl compound reactant, R"OH, at least one amide reactant selected from R-CONH.sub.2 and R-CONHR', and an inorganic catalyst, thereby reacting R"OH with said amide reactant to produce a rection mixture containing at least one disubstituted amide selected from R-CONHR".sub.2 and R-CONHR'R", whereineach of R, R' and R" contains no acetylenic unsaturation and 1 to 30 carbon atoms,each of R, R' and R" is selected from a hydrocarbyl group and a hydrocarbyl group that is substituted with a group selected from carbamoyl, hydrocarbylcarbamoyl, dihydrocarbylcarbamoyl, and hydroxyl,wherein said inorganic catalyst is selected from phosphates and sulfates of a Group 13 element and of a Group 2 metal having an atomic weight less than 145, and mixtures thereof.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: August 20, 1991
    Assignee: The Standard Oil Company
    Inventors: Mark C. Cesa, Sandra L. Denman
  • Patent number: 5015773
    Abstract: An amine is produced by reacting in the presence of hydrogen at elevated temperature a first reactant which is a compound substantially involatile at the elevated temperature employed and having either one, two or more hydroxyl functions, each of which is independently either a primary or secondary hydroxyl function, with a second reactant which is either ammonia or a primary or a secondary amine in the presence of a reductive amination catalyst wherein the reaction is effected in either a continuously or periodically open system.
    Type: Grant
    Filed: August 4, 1989
    Date of Patent: May 14, 1991
    Assignee: BP Chemicals Limited
    Inventor: Ian D. Dobson
  • Patent number: 4996348
    Abstract: Novel N-alkenoyl enamide of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or halogen, andR.sub.3 and R.sub.4 are each independently of the other C.sub.1 -C.sub.4 alkanolyl, C.sub.1 -C.sub.18 alkoxycarbonyl, benzoyl, phenyl, cyano or carbamoyl, and R.sub.4 can also be hydrogen,are used for photocrosslinkable compositions suitable for use in photographic solutions, as UV absorbers and as textile finishing agents.
    Type: Grant
    Filed: July 19, 1988
    Date of Patent: February 26, 1991
    Assignee: Ciba-Geigy Corporation
    Inventors: Martin Kuhn, Philippe Ouziel
  • Patent number: 4987257
    Abstract: Disclosed is a diacetylene compound comprising, as structural units, (a) at least one member selected from diacetylene group-containing organic groups of the formulae (I) and (II):R.sup.I --C.tbd.C--C.tbd.C--R.sup.II -- (I)and--R.sup.III --C.tbd.C--C.tbd.C--R.sup.IV -- (II)wherein R.sup.I is hydrogen or a (C1-16) monovalent organic group, and R.sup.II, R.sup.III and R.sup.IV are a (C1-13) divalent organic group, (b) at least one organic group having at least one carbon-to-carbon double bond, and (c) at least one connecting group connecting the units (a) and (b), which connecting group is selected from amide, imide, ester, ether, amino, imino, urethane, sulfonyl and carbonyl bonds. A cured shaped article made of this compound exhibits isotropically a high elastic modulus and has excellent mechanical properties.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: January 22, 1991
    Assignee: Director-General of Agency of Industrial Science and Technology
    Inventors: Katsuyuki Nakamura, Satoru Yamazaki, Jinichiro Kato, Kensaku Tokushige
  • Patent number: 4981963
    Abstract: A new process is described for the preparation of oxalic acid esters and amides of general formula (I) ##STR1## wherein Z designates an --OR or --NR.sup.1 R.sup.2 group, wherein R represents substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, R.sup.1 is hydrogen or substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, R.sup.2 represents substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or aryl-alkyl, or R.sup.1 and R.sup.2 taken together with the adjacent nitrogen atom represent a saturated 5-, 6-, 7-, or 8-membered heterocyclic ring, which may contain an additional heteroatom selected from --O--, --S--, and --N(H, Alkyl)--, and optionally bear one or more alkyl or alkenyl substituents, andZ.sup.1 designates an --OR or --NR.sup.1 R.sup.2 group, wherein R, R.sup.1, and R.sup.2 are as defined before, or a group --NHCOCH.sub.3, which comprises the base-catalysed reaction of diacetyloxamide with an alcohol ROH or/and an amine HNR.sup.1 R.sup.2.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 1, 1991
    Assignee: Enichem Anic S.p.A.
    Inventors: Giuseppe Messina, Giovanni M. Sechi, Loreno Lorenzoni, Giovanni Chessa
  • Patent number: 4978786
    Abstract: A process is described for the preparation of oxamide derivatives wherein one or both --NH.sub.2 groups are replaced by primary or secondary amino groups, through reaction of oxamide with a suitably selected amine of formula RR.sup.1 NH wherein R represents a substituted straight or branched (C.sub.2 -C.sub.12)alkyl radical wherein the substituent(s) or at least one of the substituents is selected from the group consisting of hydroxy, amino, mono-substituted amino, and di-substituted amino, and R.sup.1 represents hydrogen or an optionally substituted (C.sub.1 -C.sub.6)alkyl radical; representative oxamide derivatives which can thus be obtained useful as corrosion inhibitors, intermediates for polymers, polymer stabilizers, and slow-release fertilizers, are also described.
    Type: Grant
    Filed: April 5, 1990
    Date of Patent: December 18, 1990
    Assignee: Enichem Anic S.p.A.
    Inventors: Giuseppe Messina, Giovanni Sechi, Loreno Lorenzoni, Vittorio Bruzzi
  • Patent number: 4946625
    Abstract: The present invention involves new anti-foam compositions which control foaming in aqueous systems and by nature of their unique cloud point characteristics are insoluble and particulate above their inverse cloud point, and soluble below it. This property makes them non-depositing defoamers. As the defoamed aqueous system cools down these novel products become soluble, preventing insoluble material (pitch) from depositing on process equipment and matter being processed. The compounds of this invention allow for the formulation of mineral oil free defoamers.
    Type: Grant
    Filed: March 27, 1989
    Date of Patent: August 7, 1990
    Assignee: Siltech Inc.
    Inventor: Anthony J. O'Lenick, Jr.
  • Patent number: 4938871
    Abstract: The invention relates to the preparation and use of novel extracting agents and novel propane diamides for the recovery of actinides and/or lanthanides.These extracting agents are constituted by propane diamides of formula: ##STR1## For example, the extracting agent can be 2-hexyl-N,N'-dimethyl-N,N'-dibutyl-propane diamide or 2-ethoxyethyl-N,N'-dimethyl-N,N'-dibutyl-propane diamide.They are more particularly used for the recovery of actinides and/or lanthanides present in the trivalent state in an acid aqueous solution, particularly in a nitric solution.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: July 3, 1990
    Assignees: Commissariat a l'Energie Atomique, Institut National de Recherche Chimique Appliquee
    Inventors: Claude Musikas, Pierre Hoel, Gerard Thiollet, Louisette Lafosse
  • Patent number: 4931591
    Abstract: Compounds of the formula ##STR1## in which R.sub.1 represents hydrogen or acyl, A represents an optionally N-alkylated .alpha.-amino acid residue which is bonded N-terminally to R.sub.1 and C-terminally to the group --NR.sub.2 --, R.sub.2 represents hydrogen or lower alkyl, R.sub.3 represents hydrogen, lower alkyl, optionally etherified or esterified hydroxy-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, tricycloalkyl-lower alkyl, aryl or aryl-lower alkyl, R.sub.4 represents hydroxy or etherified or esterified hydroxy, R.sub.5 represents lower alkyl having 2 or more carbon atoms, optionally etherified or esterified hydroxy-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl, bicycloalkyl-lower alkyl, tricycloalkyl, tricycloalkyl-lower alkyl, aryl, aryl-lower alkyl, optionally substituted carbamoyl, optionally substituted amino, optionally substituted hydroxy or optionally substituted mercapto and R.sub.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: June 5, 1990
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Buhlmayer, Vittorio Rasetti, Walter Fuhrer, James L. Stanton, Richard Goschl
  • Patent number: 4908385
    Abstract: The present invention provides pharmaceutical compositions containing at least one .alpha.-halogenated dicarboxylic acid of the general formula: ##STR1## wherein Hal is a chlorine, bromine or fluorine atom, R is a hydrogen atom or Hal and m is a number of from 4 to 16, and/or at least one pharmacologically acceptable salt, ester or amide thereof.The present invention also provides new compounds of general formula (I) but in which m is a number of from 8 to 16 and processes for the preparation thereof.
    Type: Grant
    Filed: October 6, 1987
    Date of Patent: March 13, 1990
    Assignee: Epis S.A.
    Inventors: Jacob Bar-Tana, Yoelit Migron, Jochanan Blum, Bruno Dreckmann, Johannes Pill
  • Patent number: 4847412
    Abstract: The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per liter solution.The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino-acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/liter solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20.degree.-60.degree. C.
    Type: Grant
    Filed: April 10, 1986
    Date of Patent: July 11, 1989
    Assignee: Stamicarbon B.V.
    Inventors: Wilhelmus H. J. Boesten, Hans E. Schoemaker, Bernardus H. N. Dassen
  • Patent number: 4789742
    Abstract: Novel Isomaleimido and isophthalimido derivatives of chromophoric compounds are provided which are useful in analytic techniques for the detection and measurement of biological compounds such as bacteria, enzymes, hormones and the like.
    Type: Grant
    Filed: July 14, 1986
    Date of Patent: December 6, 1988
    Inventor: Spyros Theodoropulos
  • Patent number: 4780535
    Abstract: Conjugates of isomaleimides and isophthalimides and organic chromophoric compounds exhibiting fluorescence, luminescence, chemiluminescence or absorption of analytical value having the structural formula I and II ##STR1## wherein R is an organic aromatic molecule which may be substituted, heteroaromatic which may be substituted, aliphatic having 1 to 50 carbon atoms and which may be substituted or an organic chromophoric molecule exhibiting fluorescence, luminescence, chemiluminiescence or absorption of analytical value. R' is an organic chromophoric molecule exhibiting fluorescence, luminescence, chemiluminescence, or absorption of analytical value; R.sub.1 is hydrogen, halogen, carboxylic, alkyl, aryl, hydroxyl, amino group which may be substituted, nitro or sulfonic group. R.sub.2, R.sub.3 and R.sub.4 have the same meaning as R.sub.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: October 25, 1988
    Inventor: Spyros Theodoropulos
  • Patent number: 4770807
    Abstract: The invention relates to novel extracting agents and novel propane diamides, their use for the recovery of actinides and/or lanthanides and their preparation process. These extracting agents are constituted by propane diamides of formula: ##STR1## For example, the extracting agent can be 2-hexyl-N,N'-dimethyl-N,N'-dibutyl-propane diamide or 2-ethoxyethyl-N,N'-dimethyl-N,N'-dibutyl-propane diamide. They are more particularly used for the recovery of actinides and/or lanthanides present in the trivalent state in an acid aqueous solution, particularly in a nitric solution.
    Type: Grant
    Filed: July 21, 1986
    Date of Patent: September 13, 1988
    Assignees: Commissariat a l'Energie Atomique, Institut National de Recherche Chimique Appliquee
    Inventors: Claude Musikas, Pierre Hoel, Gerard Thiollet, Louisette Lafosse
  • Patent number: 4755623
    Abstract: A sterically unhindered, trifunctional primary amine is provided. This compound is useful as a crosslinking agent for a composition containing an amine-reactive polymer. Also provided is a low temperature cure composition containing the amine-reactive polymer and the trifunctional primary amine, and a crosslinked coating obtained by curing such a composition. Additionally, there is provided a process of synthesizing the novel trifunctional primary amine.
    Type: Grant
    Filed: September 6, 1983
    Date of Patent: July 5, 1988
    Assignee: American Cyanamid Company
    Inventor: Roland Dileone
  • Patent number: 4716226
    Abstract: Novel 2-azetidinones of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, --OH, protected hydroxy and --OCH.sub.2 --COOR', R' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sub.2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and hydroxyl protective group and a novel process and novel intermediates for their preparation and a process for the preparation of compounds of the formula ##STR2## wherein R has the above definition, R'd is selected from the group consisting of hydrogen, --OH and protected hydroxyl and R.sub.3 is selected from the group consisting of hydrogen and R.sub.3 ', R.sub.3 ' is amino protective group which are useful intermediates.
    Type: Grant
    Filed: October 28, 1985
    Date of Patent: December 29, 1987
    Assignee: Roussel Uclaf
    Inventors: Stephane Gero, Jeanine Cleophax, Alice Gateau-Olesker
  • Patent number: H1043
    Abstract: Novel bis-hydroxy diamides having the formula: ##STR1## where R is an alkyl or aryl moiety having from 3 to 10 carbon atoms and where x ranges from 1 to 6 may be produced by reacting dicarboxylic acids with polyethylene glycol monoamines. Suitable dicarboxylic acids include adipic acid, terephthalic acid, isophthalic acid, t-butyl isophthalic acid, 1,1,3-trimethyl-5-carboxy-3-(p-carboxyphenyl)indane, and mixtures thereof. Suitable monoamines include diethylene glycol monoamine, also known as Diglycolamine.RTM. amine (DGA); triethylene glycol monoamine (TEGMA) and tetraethylene glycol monoamine (T.sub.4 EGMA), among others. The resulting bis-hydroxy diamides are useful to make hydroxy-terminated polyamides and as fuel additive corrosion inhibitors. The diamides have unusual solubility properties.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: April 7, 1992
    Assignee: Texaco Chemical Company
    Inventors: George P. Speranza, Jiang-Jen Lin