And Sulfur Or Oxygen Bonded Indirectly To Phosphorus Patents (Class 568/15)
  • Patent number: 11898046
    Abstract: A photopolymerization initiator which is a compound having a structure in which one or more carbonyl groups that link to a carbon atom are further directly bonded to an aromatic ring of an aromatic acyl group that bonds to a phosphorus atom in an acylphosphine oxide structure. A producing method of a photopolymerization initiator produces the photopolymerization initiator. In a polymerizable composition and an ink jet recording method, the photopolymerization initiator is used. Furthermore, an acylphosphine oxide compound has a partial structure represented by Formula 1 or Formula 2.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: February 13, 2024
    Assignee: FUJIFILM CORPORATION
    Inventors: Hiroaki Tsuyama, Kazuhiro Yokoi, Kouki Nakamura, Kenjiro Araki
  • Patent number: 11466041
    Abstract: The present subject matter provides a safe alternative for producing an important intermediate useful for preparing the herbicide glufosinate, without need for chlorine components in the manufacturing process. In particular, a process for preparing alkyl phosphinic aid alkyl ester is provided, including the step of alkylating alkyl phosphinic acid ester in a non-polar solvent in the same apparatus as used to first produce the alkyl phosphinic acid ester, and without isolating the alkyl phosphinic acid ester before the alkylation step is conducted. More specifically, a process is presented for preparing methyl phosphinic acid butyl ester, by alkylating butyl phosphinic acid ester in a non-polar solvent, in the same apparatus as used previously to first produce the butyl phosphinic acid ester and without isolating the butylphosphinic acid ester before alkylation.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: October 11, 2022
    Assignee: ADAMA AGAN LTD.
    Inventors: Avihai Yacovan, Alexander Shterenberg, Leonid Erchov, Sveta Fronton, Gerd-Volker Roeschenthaler, Mykhailo Shevchuk, Olesya Stubbmann-Kazakova, Nataliya Kalinovich
  • Patent number: 10183959
    Abstract: The invention relates to compounds which correspond to the general formula (I) below: in which: R1 and R2 represent, independently of one another, a C4 to C12 acyclic hydrocarbon group; R3 represents H; a C1 to C12 acyclic hydrocarbon group with optionally one or more heteroatoms; a C5 or C6 cyclic hydrocarbon group; or a 5- or 6-membered heterocyclic group; R4 represents H or a C1 to C12 acyclic hydrocarbon group with optionally one or more heteroatoms; R5 and R6 represent, independently of one another, H; a C1 to C12 acyclic hydrocarbon group with optionally one or more heteroatoms; a C5 or C6 cyclic hydrocarbon group; or a 5- or 6-membered heterocyclic group; on the condition however that R5 and R6 do not each represent H.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: January 22, 2019
    Assignees: COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stéphane Pellet-Rostaing, Antoine Leydier, Guilhem Arrachart, Raphaël Turgis, Véronique Dubois
  • Publication number: 20150065738
    Abstract: The present invention provides a phosphorous compound represented by general formula (1), and transition metal complexes containing such phosphorous compounds as ligands: wherein R1 to R7, A, B, Y, and Z have the same meanings as those defined in the specification.
    Type: Application
    Filed: August 22, 2014
    Publication date: March 5, 2015
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Naota YOKOYAMA, Yuji NAKAYAMA
  • Patent number: 8962600
    Abstract: Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: February 24, 2015
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Balaraman Kalyanaraman, Joy Joseph, Anumantha Kanthasamy
  • Patent number: 8957236
    Abstract: The compounds represented by the following general formula have excellent properties as a charge transport material. In the formula, R1 to R3 represent a substituent, n1 and n2 indicate an integer of from 0 to 5, n3 indicates an integer of from 0 to 4, X represents a linking group of —O—, —S—, —SO2—, —CS—, —R4—, —C(R5)(R6)—, —PO(R7)—, —Si(R8)(R9)—, >PO—, >Si(R10)— or >Si<, m is an integer of from 2 to 4, R4 represents an aliphatic cyclic linking group, and R5 to R10 represent a hydrogen atom, an alkyl group, an aryl group, etc.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: February 17, 2015
    Assignee: Kyushu University National University Corporation
    Inventors: Qisheng Zhang, Chihaya Adachi, Shigeyuki Matsunami, Kei Sakanoue
  • Publication number: 20150018579
    Abstract: The 5? and 3?-thiol modified oligonucleotides are attractive tools with a vast number of potential applications in the field of nucleic acid chemistry. There is a strong interest in developing new disulfide compounds or to optimize synthesis of existing disulfide modifiers, which are efficient in generating the 3?- or 5?-end reactive thiol group. Various synthetic protocols have been employed to synthesize pure 3-((3-(bis(4-dimethoxytrityl)propyl)di-sulfanyl)propyl 2-cyanoethyl diisopropylphosphoramidite (compound 2) starting from 3-(dimethoxytrityl)propyl)disulfanyl)pro-pan-1-ol, (compound 1). Herein, we describe an efficient, reproducible synthetic and purification protocol for target compound 2 from the compound 1. It is noteworthy that our reaction conditions were reproducible even at multi-gram scale (27 g) with a purity level as achieved in a small scale.
    Type: Application
    Filed: February 22, 2012
    Publication date: January 15, 2015
    Inventors: Suresh C. Srivastava, Santhosh K. Thatikonda, Praveen Shukla, Sant Kumar Srivastav
  • Publication number: 20140353649
    Abstract: The present invention relates to an organic electronic device, comprising a first electrode, a second electrode, and a substantially organic layer comprising a compound according to formula (I) between the first and the second electrode: wherein A1 is a C6-C20 arylene and each of A2-A3 is independently selected from a C6-C20 aryl, wherein the aryl or arylene may be unsubstituted or substituted with groups comprising C and H or with a further LiO group, provided that the given C count in an aryl or arylene group includes also all substituents present on the said group.
    Type: Application
    Filed: November 30, 2012
    Publication date: December 4, 2014
    Inventors: Sascha Dorok, Carsten Rothe, Omrane Fadhel, Francois Cardinali
  • Patent number: 8816112
    Abstract: Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: August 26, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Zhengxu Han, Chris Hugh Senanayake
  • Publication number: 20140234703
    Abstract: An electro lye includes a compound of Formula I or IA: where each instance of R1 is independently H, alkyl, alkoxy, alkenyl, aryl, heteroaryl, or cycloalkyl; each instance of R2 is independently H, alkyl, alkoxy, alkenyl, aryl, heteroaryl, or cycloalkyl; each instance of R3 is independently H, alkyl, alkenyl, aryl, or cycloalkyl; each instance of R4 is independently H, halogen, CN, NO2, phosphate, alkyl, alkenyl, aryl, heteroaryl, or cycloalkyl; x is 1, 2, 3, 4, or 5; y is 1 or 2; and z is 0, 1, 2, 3, or 4.
    Type: Application
    Filed: July 20, 2012
    Publication date: August 21, 2014
    Applicant: UChicago Argonne, LLC
    Inventors: Lu Zhang, Zhengcheng Zhang, Khalil Amine
  • Publication number: 20140221632
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: April 7, 2014
    Publication date: August 7, 2014
    Inventors: Chun-Hsu LIN, Chian-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Publication number: 20140135506
    Abstract: Disclosed are methods for making chiral phosphorus ligands including chiral phosphines, chiral phosphine oxides, phosphonamides, and aminophosphines. The chiral phosphorus ligands prepared by the methods of the invention are useful as components of chiral catalysts, e.g., transition metal complexes.
    Type: Application
    Filed: November 14, 2013
    Publication date: May 15, 2014
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Zhengxu HAN, Chris Hugh SENANAYAKE
  • Publication number: 20140135530
    Abstract: The compounds represented by the following general formula have excellent properties as a charge transport material. In the formula, R1 to R3 represent a substituent, n1 and n2 indicate an integer of from 0 to 5, n3 indicates an integer of from 0 to 4, X represents a linking group of —O—, —S—, —SO2—, —CS—, —R4—, —C(R5)(R6)—, —PO(R7)—, —Si(R8)(R9)—, >PO—, >Si(R10)— or >Si<, m is an integer of from 2 to 4, R4 represents an aliphatic cyclic linking group, and R5 to R10 represent a hydrogen atom, an alkyl group, an aryl group, etc.
    Type: Application
    Filed: June 22, 2012
    Publication date: May 15, 2014
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Qisheng Zhang, Chihaya Adachi, Shigeyuki Matsunami, Kei Sakanoue
  • Publication number: 20140011986
    Abstract: The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to shorten the reaction time as a result of minimized the byproduct(s) formation, and obtain high purity (>99.0%) of parylene AF4 product under high concentrated reaction mixture.
    Type: Application
    Filed: September 21, 2012
    Publication date: January 9, 2014
    Inventors: Chun-Hsu LIN, Chien-Yi SUN, Yung-Yu YIN, Chun-Shih LI, Yo-Chun CHOU
  • Publication number: 20130310606
    Abstract: Method produces polyprenyl phosphates of formula, where each isoprene unit contains 5 carbon atoms, W is ?-end isoprene, T is trans-isoprene, C is cis-isoprene, S is 2,3-dihydroisoprene, a=0-10, b=0-39, c=0-1, a+b+c=4-40, and X is of formula OPO3MM?, wherein M and M? are identical or different and are a hydrogen cation or monovalent inorganic or organic cation, or M and M? together are divalent inorganic or organic cation, the phosphorylation of the relevant polyprenol or a mixture of oligomer homologues, where X is hydroxyl group, using a substituted ammonium salt of phosphoric acid in presence of condensing agent, is carried out in a medium of first aprotic organic solvent; and a polyprenyl phosphate of mono- or disubstituted salts thereof with monovalent cations or in form of salts thereof with divalent cations is isolated by extraction and precipitation.
    Type: Application
    Filed: December 28, 2011
    Publication date: November 21, 2013
    Applicant: Obschestvo S Ogranichennoy Otvetstvennostyu Gamavetfarm (OOO GAMAVETFARM)
    Inventor: Leonid Leonidovich Danilov
  • Patent number: 8492593
    Abstract: Amido-fluorophosphite compounds and catalyst systems comprising at least one amido-fluorophosphite ligand compound in combination with a transition metal are described. Moreover, the use of amido-fluorophosphite containing catalysts for transition metal catalyzed processes, especially to the hydroformylation of various olefins to produce aldehydes are also described.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: July 23, 2013
    Assignee: Eastman Chemical Company
    Inventor: Thomas Allen Puckette
  • Patent number: 8410313
    Abstract: Provided herein are ruthenium complexes of Formula I, and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: April 2, 2013
    Assignee: Idenix Pharmaceuticals, Inc.
    Inventors: Christophe Claude Parsy, Francois-Rene Alexandre, Florence Marie-Emilie Bonnaterre, Dominique Surleraux
  • Publication number: 20130004840
    Abstract: A non-aqueous electrolyte additive for a lithium secondary battery, a non-aqueous electrolyte for a lithium secondary battery, and a lithium secondary battery, the additive including a bidentate phosphorus compound represented by the following Chemical Formula 1.
    Type: Application
    Filed: February 1, 2012
    Publication date: January 3, 2013
    Inventors: Jung-Yi YU, Woo-Cheol Shin, Sang-Il Han, Mi-Hyun Lee, Tae-Hyun Bae
  • Patent number: 8236980
    Abstract: The principal object of the invention is to provide a lithium salt having excellent ion conductivity. The invention solves the problem by providing a lithium salt having a structure represented by the general formula (1): in which “M” represents B, Si, Ge, P, As or Sb; “X” represents the valence of “M”; “R1” represents —CmH2m— whereupon “m” is an integer of 1 to 4; “R2” represents —CkH2k+1 whereupon “k” is an integer of 1 to 8; and “n” represents 0 to 12.
    Type: Grant
    Filed: September 13, 2007
    Date of Patent: August 7, 2012
    Assignees: National University Corporation Shizuoka University, Toyota Jidosha Kabushiki Kaisha
    Inventors: Tatsuo Fujinami, Ruoyuan Tao, Masaki Matsui
  • Publication number: 20120157418
    Abstract: This invention discloses 2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-2-methylene-19-nor-vitamin D3 and (20R)-25-hydroxy-2-methylene-19-nor-vitamin D3, as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. Although these compounds have relatively low calcemic activities they may also be useful in the treatment of bone diseases due to their ability to act as prodrugs in vivo.
    Type: Application
    Filed: October 21, 2011
    Publication date: June 21, 2012
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hector F. DeLuca, Izabela Sibilska, Lori A. Plum, Margaret Clagett-Dame, Rafal R. Sicinski, Katarzyna M. Barycka, Katarzyna Plonska-Ocypa, Rafal Barycki
  • Publication number: 20120142805
    Abstract: The invention pertains to an oligomer or polymer substituted by one or more bisacylphosphine oxide moieties, characterized in that said bisacylphosphine oxide moiety is linked via the phosphorous atom, optionally via a spacer group, to the oligomer or polymer backbone; as well as to specifically functionalized bisacylphosphine oxides, suitable to prepare said polymers or oligomers.
    Type: Application
    Filed: June 29, 2010
    Publication date: June 7, 2012
    Applicant: BASF SE
    Inventors: Hansjorg Grutzmacher, Timo Ott, Kurt Dietliker
  • Patent number: 8193384
    Abstract: The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, ?-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: June 5, 2012
    Assignee: Board of Governors for Higher Education, State of Rhode Island and Providence Plantation
    Inventors: Keykavous Parang, Yousef Ahamdibeni
  • Publication number: 20120115963
    Abstract: A process for the preparation of a polymer nanoparticle by a photoinduced emulsion polymerization includes preparing an emulsion comprising at least one surfactant, a dispersed phase and a continuous phase. The dispersed phase comprises at least one polymerizable monomer and the continuous phase comprises water and at least one photoinitiator. The at least one polymerizable monomer is polymerized by exposing the emulsion to an electromagnetic radiation having a wavelength so as to induce a generation of radicals from the at least one photoinitiator.
    Type: Application
    Filed: April 16, 2010
    Publication date: May 10, 2012
    Applicant: ETH ZUERICH
    Inventors: Hansjoerg Gruetzmacher, Timo Ott
  • Patent number: 8119617
    Abstract: The present invention relates to compounds of formula wherein the residues have various meanings and their use as pharmaceuticals.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: February 21, 2012
    Assignee: Novartis AG
    Inventors: Karl Baumann, Andreas Billich, Berndt Oberhauser
  • Publication number: 20120041191
    Abstract: Provided herein are ruthenium complexes of Formula (I), and processes of preparation thereof. Also provided are methods of their use as a metathesis catalyst.
    Type: Application
    Filed: February 2, 2010
    Publication date: February 16, 2012
    Applicant: Idenix Pharmaceuticals, Inc.
    Inventors: Christophe Claude Parsy, Francois-Rene Alexandre, Florence Marie-Emilie Bonnaterre, Dominique Surleraux
  • Publication number: 20110294709
    Abstract: The present invention provides an anti-wear compound selected from phosphorus compounds as represented by the following General Formula (2) or metal salts thereof as represented by the following General Formula (3).
    Type: Application
    Filed: January 28, 2010
    Publication date: December 1, 2011
    Inventors: Eiji Nagatomi, Tetsuo Wakizono
  • Patent number: 8039676
    Abstract: A process for producing a compound of the formula: including reacting of a compound of the formula: with diphenyl phosphine oxide using a binary phase reaction mixture including diphenyl phosphine oxide in an organic solvent, a basic aqueous solution, and a phase transfer catalyst, to obtain the compound of formula 1, wherein Ph is phenyl, X1 and X2 are both hydrogen or X1 and X2 taken together are CH2, R1 is a protecting group, R2 is fluorine, hydrogen, or OR3, wherein R3 is a protecting group, and the squiggly line represents a bond that results in the adjacent double bond being in either the E or Z configuration, is disclosed.
    Type: Grant
    Filed: May 29, 2008
    Date of Patent: October 18, 2011
    Assignee: Cytochroma Inc.
    Inventor: Uttam Saha
  • Publication number: 20110218345
    Abstract: [Problem to be Solved] To provide an axially asymmetric optically active biarylphosphorus compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. [Means for Solving the Problems] A method for producing an axially asymmetric phosphorus compound represented by the general formula (1), comprising a cycloaddition reaction of a compound having a triple bond with the use of a catalyst containing rhodium metal and an optically active bisphosphine. (In the formula (1), R1 and R2 may be the same or different and independently are an alkyl group optionally having a substituent group, a cycloalkyl group optionally having a substituent group, an aryl group optionally having a substituent group, an alkoxy group optionally having a substituent group or an aryloxy group optionally having a substituent group; * is axial asymmetry.
    Type: Application
    Filed: March 7, 2011
    Publication date: September 8, 2011
    Inventors: Ken TANAKA, Tohru Yokozawa, Tomohiko Hakamata
  • Publication number: 20110129871
    Abstract: A specific culture medium for growth, detection, identification and/or counting of Staphylococcus aureus bacteria, said medium includes at least one fluorogenic, chromogenic or luminescent substrate of phospholipase C. Said medium permits differentiation between Staphylococcus aureus and coagulase-negative staphylococci.
    Type: Application
    Filed: August 13, 2009
    Publication date: June 2, 2011
    Applicant: BIOMERIEUX
    Inventors: David Mosticone, Sylvain Orenga, Antoine Vimont, Yuping Guo, Martine Dhedin
  • Publication number: 20110118482
    Abstract: Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z1-Q-P*R0R1 (I) in which Z1 is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z1 is the —P*R0R1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group Z1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*R0R1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally i
    Type: Application
    Filed: November 14, 2008
    Publication date: May 19, 2011
    Inventors: Benoît Pugin, Matthias Lotz, Heidi Landert, Adrian Wyss, Raphael Aardoom, Bjõrn Gschwend, Andreas Pfaltz, Felix Spindler
  • Publication number: 20110098485
    Abstract: Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(?O)HR1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group —P(R)2; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C1-C4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C1-C4-alkylene group, and in which base skeletons a P-chiral group —P*(O)HR1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R1 is a hydrocarbon radi
    Type: Application
    Filed: November 14, 2008
    Publication date: April 28, 2011
    Inventors: Benoît Pugin, Heidi Landert, Björn Gschwend, Andreas Pfaltz, Felix Spindler
  • Publication number: 20110082121
    Abstract: This invention discloses 1-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.
    Type: Application
    Filed: September 30, 2010
    Publication date: April 7, 2011
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hector F. DeLuca, Katarzyna M. Barycka, Izabela Sibilska, Lori A. Plum, Margaret Clagett-Dame, Rafal Barycki, Rafal R. Sicinski, Katarzyna Plonska-Ocypa
  • Patent number: 7902403
    Abstract: The present invention relates to oligomeric or polymer dithiophosphate di- or poly-sulfides and their utility in rubbers. Another aspect of the invention is a method for making oligomeric or polymeric dithiophosphates by reacting phosphorous pentasulfide with a di- or polyol and a mono alcohol to produce a dithiophosphoric acid, and then oxidizing the dithiophosphoric acid with an oxidizing agent to produce an oligomeric or polymeric dithiophosphate.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: March 8, 2011
    Assignee: R.T. Vanderbilt Company, Inc.
    Inventors: Thomas J. Karol, Ronald J. Tepper
  • Patent number: 7838706
    Abstract: The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4?-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3?-position of their B aryl ring. Similarly, 3?-amino combretastatin is 4?-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: November 23, 2010
    Assignee: Zhejiang Dade Pharmaceutical Group Co. Ltd
    Inventors: Weiping Shen, Jianping Wang, Jianguo Wang
  • Publication number: 20100291185
    Abstract: This application discloses compositions containing synthetic threitol phosphates, in particular threitol monophosphate, threitol-bis-phosphate, threitol diphosphate, and/or threitol triphosphate. The threitol phosphates are useful in treating wounds, for cosmetic applications, and for bone and periodontal regeneration.
    Type: Application
    Filed: November 17, 2009
    Publication date: November 18, 2010
    Applicant: SUNNY BIODISCOVERY, INC.
    Inventors: Hui Zhao, Krzysztof Bojanowski, Fariba Aria, Reza Mortezaei
  • Patent number: 7820862
    Abstract: Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R1 and R2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A1-A4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A2 and A3 combine together to form a ring.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: October 26, 2010
    Assignee: The University of Tokyo
    Inventors: Masakatsu Shibasaki, Motomu Kanai, Ikuo Fujimori, Kenzo Yamatsugu, Shin Kamijo
  • Publication number: 20100221180
    Abstract: A molecular probe for labeling myelin includes a fluorescent stilbenzene derivative.
    Type: Application
    Filed: September 2, 2008
    Publication date: September 2, 2010
    Inventors: Yanming Wang, Chunying Wu
  • Patent number: 7777080
    Abstract: The invention relates to carboxylic acid derivates which contain at least one organically polymerisable group and at least one group which contains phosphorous and is reactive or that modulates the properties of the molecule. The invention also relates to a method for production of the inventive molecules and the use thereof in dentistry and for influencing the properties of materials.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: August 17, 2010
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung E.V.
    Inventors: Herbert Wolter, Somchith Nique
  • Publication number: 20100204184
    Abstract: The invention concerns novel phosphonate derivatives, preparation method, use thereof as ligands modulating T ?9?2 lymphocyte activity and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 14, 2010
    Publication date: August 12, 2010
    Applicants: LABORATOIRES MAYOLY SPINDLER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE MONTPELLIER II
    Inventors: Jean-Louis Montero, Ibrahim Zgani, Chantal Menut, Valérie Gallois
  • Patent number: 7772439
    Abstract: An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure: is provided. Such building block may be introduced in the 5? end position of an amino acid under standard coupling conditions. Such building block allows in-line coupling control, “trityl-on” purification, and solid support functionalization/derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: August 10, 2010
    Assignee: Operon Biotechnologies, Inc.
    Inventors: Patrick A. Weiss, Violette Y. Weiss, Stefan Pitsch
  • Patent number: 7772440
    Abstract: A novel process for preparing in a high purity and in a high yield phosphonates having a secondary and/or tertiary alcoholic hydroxyl group at the end of a P—C bond chain thereof with the use of a phosphite and a carbonyl compound as raw materials.
    Type: Grant
    Filed: October 18, 2005
    Date of Patent: August 10, 2010
    Assignee: Daihachi Chemical Industry Co., Ltd.
    Inventors: Makoto Kyoda, Manabu Hirata
  • Publication number: 20100190901
    Abstract: The invention relates to alkylphosphonous acids, salts and esters of formula (I) A-P(?O)(OX)—H (I) wherein A is C2-C20alkyl, C2-C20alkylene, and C8-C20 alkaryl are optionally substituted, and X is H, alkyl, aryl, alkylaryl, alkenyl, substituted alkyl, aryl, alkaryl, alkenyl, ammonium, primary, secondary, tertiary, quaternary alkyl and/or aryl ammonium, an alkali metal, an alkaline earth metal, a metal of the third and fourth main group and the second, fourth and eight sub-group or a metal of the lanthanoid group. The invention also relates to methods for producing same and to the uses of said compounds.
    Type: Application
    Filed: July 2, 2008
    Publication date: July 29, 2010
    Applicant: CLARIANT FINANCE (BVI) LIMITED
    Inventors: Michael Hill, Harald Bauer, Werner Krause
  • Publication number: 20100174079
    Abstract: Disclosed is a process for producing an optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus in a simple manner and at high efficiency, while avoiding racemization. An optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus represented by the general formula (III) can be produced by reacting an optically active phosphorus compound having an R- or S-type absolute configuration on phosphorus represented by the general formula (I) with a metal compound represented by the general formula (II) and water. (I) wherein R1 represents a hydrogen atom, analkyl group, a cycloalkyl group, an aralkyl group or an aryl group; and R2 represents a hydrogen, an alkyl group, a cycloalkyl group, an aryl group, an aralkyl group, alkenyl group, an alkoxy group, an aryloxy group, a heterocyclic ring residue or a silyl-containing group. R3M (II) wherein R3 is the same as R2; and M represents a lithium or magnesium halide MgX (X?Cl, Br or I).
    Type: Application
    Filed: August 20, 2007
    Publication date: July 8, 2010
    Applicant: National Institute of Advanced Industrial Science Technology
    Inventors: Li-Biao Han, Qing Xu
  • Publication number: 20100152491
    Abstract: Processes for preparing (E)-2,4,6-(Trimethoxystyryl)-3-O-Phosphate Disodium-4-Methoxybenzyl Sulfones and uses thereof as antiproliferative agents, including, for example, anticancer agents, and as radioprotective and chemoprotective agents.
    Type: Application
    Filed: December 17, 2008
    Publication date: June 17, 2010
    Inventor: REDDY SIRIGIREDDY
  • Publication number: 20100144678
    Abstract: Small molecule bradykinin inhibitor bisphosphonate amide derivatives useful for inhibiting cancer growth and treating cancer residing in and around bone are disclosed. These compounds and pharmaceutical compositions containing these compounds are particularly useful for the treatment of prostate cancer bone metastases.
    Type: Application
    Filed: April 9, 2008
    Publication date: June 10, 2010
    Applicant: The Regents of the University of colorado, a body corporate
    Inventors: Lajos Gera, John M. Stewart, Leland W.K. Chung, Daqing Wu
  • Publication number: 20100098641
    Abstract: A mutual prodrug of an AISTM and a ?-agonist in formulation for delivery by aerosolization to inhibit pulmonary inflammation and bronchoconstriction is described. The mutual prodrug is preferably formulated in a small volume solution (10-500 ?L) dissolved in a quarter normal saline having pH between about 5.0 and 7.0 for the treatment of respiratory tract inflammation and bronchoconstriction by an aerosol having mass median average diameter predominantly between about 1 to 5?, produced by nebulization or by dry powder inhaler.
    Type: Application
    Filed: December 12, 2007
    Publication date: April 22, 2010
    Inventors: William Baker, Marcin Stasiak, Sundaramoorthi Swaminathan, Musong Kim
  • Publication number: 20100081634
    Abstract: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.
    Type: Application
    Filed: May 26, 2006
    Publication date: April 1, 2010
    Applicant: METABASIS THERAPEUTICS, INC.
    Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
  • Patent number: 7687632
    Abstract: Process for the preparation of substituted pyridine derivatives of formula (I) comprising reaction of a ?-?-unsaturated carbonyl compound of formula (II) R3—C(O)—C(R1)?C(R2)-G with a Wittig reagent or Horner-Wadsworth-Emmons reagent in the presence of a base and optionally subsequent cyclization.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 30, 2010
    Assignee: Dow AgroSciences LLC
    Inventors: Joachim Gebhardt, Norbert Götz, Hagen Jaedicke, Guido Mayer, Michael Rack
  • Patent number: 7687657
    Abstract: The invention relates to a process for the preparation of (bis)acylphosphanes of formula I, wherein n and m are each independently of the other 1 or 2; R1 if n=1, is e.g. unsubstituted or substituted C1-C18alkyl or C2-C18alkenyl, or phenyl, R1 if n=2, is e.g. a divalent radical of the monovalent radical defined above; R2 is e.g. C1-C18alkyl, C3-C12cycloalkyl, C2-C18alkenyl, mesityl, phenyl, naphthyl; R3 is one of the radicals defined under R1; the process comprises the steps a) contacting e.g.
    Type: Grant
    Filed: November 14, 2005
    Date of Patent: March 30, 2010
    Assignee: Ciba Speciality Chemicals Corporation
    Inventors: Peter Murer, Jean-Pierre Wolf, Stephan Burkhardt, Hansjörg Grützmacher, Daniel Stein, Kurt Dietliker
  • Publication number: 20100075926
    Abstract: The invention provides methods and compounds for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (Amyotrophic Lateral Sclerosis), traumatic brain injury, ischemic brain injury or a stroke. In one aspect the compounds are HDAC1 activators. Exemplary HDAC1 activators include metal chelators, iron chelators, deferoxamin, flavonoids, compounds comprising a catechol moity, ginkgetin K, Chembridge 5104434, sciadopilysin, tetrahydrogamboic acid, TAM-11, LY 235959, CGS 19755, SK&F 97541, etidronic acid, levonordefrin, methyldopa, ampicillin trihydrate, D-aspartic acid, gamma-D-glutamylaminomethylsulfonic acid, phenazopyridine to hydrochloride, oxalamine citrate salt, podophyllotoxin, SK&F 97541, (+-)-4-amino-3-(5-chloro-2-thienyl)-butanoic acid, (RS)-(tetrazol-5-yl) glycine, R(+)-SKF-81297, gambogic acid, and derivatives thereof.
    Type: Application
    Filed: July 23, 2009
    Publication date: March 25, 2010
    Inventors: Li-Huei Tsai, Stephen J. Haggarty, Dohoon Kim