Sulfur Or Oxygen Bonded Directly To A Ring Patents (Class 568/23)
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Patent number: 9359294Abstract: The invention provides a compound of formula A, B, C or D, methods for making them, intermediates therefor, and their use in making organic biologically active compounds: Wherein: X=F, Cl, Br, I, sulfonate esters, phosphate esters or another leaving group R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 are each individually selected from H, alkyl, aryl, alkynyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxy, nitro, halogen or amino; or are selected from H, C1-C10 alkyl, aryl, C1-C10 alkynyl, C1-C10 alkenyl, C1-C10cycloalkyl, C1-C10 cycloalkenyl, C1-C10 alkoxy, nitro, halogen or amino R11=tetrafluoroborate, triflate, halogen, perclorate, sulfates, phosphates or carbonates Excluding the case when: X=F and R1=R2=R3=R4=R5=H and R6=R7=R8=R9=methyl, R10=H and R11=triflate or tetrafluoroborate; or Wherein: X=F, Cl, Br, I, sulfonate esters, phosphate esters or other another leaving group; and R1, R2, R3, R4, R5 are each individually selected from H, alkyl, aryl, alkynyl, alkenyl, cycloalkyl, cycloalkenyl, alkoxType: GrantFiled: January 20, 2016Date of Patent: June 7, 2016Assignee: Hovione Inter LimitedInventor: Emilia Perpetua Tavares Leitao
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Patent number: 9290446Abstract: The invention provides electrophilic monohalomethylating reagents, methods for their preparation and methods for preparation of monohalomethylated biologically active compounds using such reagents. Typical monohalomethyl groups transferred are FH2C—, CIH2C— and others. The reagents used for transferal of the groups are described by Formulae A-D: wherein: X=F, Cl, Br, I, sulfonate esters, phosphate esters or another leaving group; R11=tetrafluoroborates, inflates, halogen, perchlorate, sulfates, phosphates or carbonates The other variables are as defined in the claims.Type: GrantFiled: October 27, 2011Date of Patent: March 22, 2016Assignee: Hovione Inter LimitedInventor: Emilia Perpetua Tavares Leitao
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Publication number: 20150029577Abstract: A surfactant includes a hydrophobic functional group, a hydrophilic functional group and a linker disposed between the hydrophobic functional group and the hydrophilic functional group. The linker is connected to the hydrophobic functional group and the hydrophilic functional group. The linker has a cleavable bond with a bond energy lower than a bond energy of a bond included in the hydrophilic functional group and a bond included in the hydrophobic functional group.Type: ApplicationFiled: October 6, 2014Publication date: January 29, 2015Inventors: Sung-Chan Jo, Jae-Cheol Park, Sang-Ji Park, Hye-Young Park, Yiying Jia, Min-Jeong Oh, Hee-June Kwak
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Publication number: 20140235565Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.Type: ApplicationFiled: May 1, 2014Publication date: August 21, 2014Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: EDWARD TUROS, KEVIN D. REVELL
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Patent number: 8759264Abstract: The invention relates to water-based hydraulic fluids comprising a) water, b) at least one glycol, a polyglycol, or both, and c) 0.1 to 30 wt % of at least one compound of formula 1, where M is hydrogen, an alkali metal, an alkali earth metal, or ammonia, Ar1 and Ar2 are independently monocyclic or polycyclic aromatic groups that can have substituents or can comprise heteroatoms.Type: GrantFiled: December 2, 2009Date of Patent: June 24, 2014Assignee: Clarient Finance (BVI) LimitedInventors: Rainer Kupfer, Carsten Cohrs
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Patent number: 8722937Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and method of their use as anti-bacterial agents.Type: GrantFiled: February 27, 2007Date of Patent: May 13, 2014Assignee: University of South FloridaInventors: Edward Turos, Kevin D. Revell
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Publication number: 20140120159Abstract: Cyanide antidote compositions and methods of use are described herein. A cyanide antidote composition may include a sulfur analog, sulfur analog derivative, or a pharmaceutically acceptable derivative of a sulfur analog.Type: ApplicationFiled: October 30, 2013Publication date: May 1, 2014Applicant: Sam Houston UniversityInventors: Ilona Petrikovics, Csaba Jaszberenyi
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Publication number: 20140038871Abstract: Described are multi-ring antioxidant products comprising at least one sulfur-bridged aromatic hydrocarbon compound substituted on at least one of its aromatic rings by at least one sterically hindered 3,5-dihydrocarbyl-4-hydroxybenzyl moiety. Such products have the formula: R—Sn—R[—S—R]m wherein each R is, independently, an aromatic hydrocarbon group having 6-12 carbon atoms, wherein m is 0-20, wherein n is 1-6 when m is 0, and when n is 1, m is 1-20; and wherein at least one of R, R1, and R2 is substituted by at least one such sterically hindered moiety. The preparation of such products and their use as antioxidants in compositions normally susceptible to oxidative degradation in oxygen or air, e.g., liquid fuel and lubricants, are also described.Type: ApplicationFiled: October 8, 2013Publication date: February 6, 2014Applicant: Albemarle CorporationInventor: Mahmood Sabahi
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Patent number: 8617791Abstract: The present invention relates to a fluorine-free photoacid generator (PAG) and a photoresist composition containing the same. The PAG is characterized by the presence of an onium cationic component and a fluorine-free fused ring heteroaromatic sulfonate anionic component containing one or more electron withdrawing substituents. The onium cationic component of the PAG is preferably a sulfonium or an iodonium cation. The photoresist composition further contains an acid sensitive imaging polymer. The photoresist composition is especially useful for forming material patterns on a semiconductor substrate using 193 nm (ArF) lithography.Type: GrantFiled: September 13, 2012Date of Patent: December 31, 2013Assignee: International Business Machines CorporationInventors: Sen Liu, Pushkara R. Varanasi
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Patent number: 8518630Abstract: The present invention relates to a fluorine-free photoacid generator (PAG) and a photoresist composition containing the same. The PAG is characterized by the presence of an onium cationic component and a fluorine-free fused ring heteroaromatic sulfonate anionic component containing one or more electron withdrawing substituents. The onium cationic component of the PAG is preferably a sulfonium or an iodonium cation. The photoresist composition further contains an acid sensitive imaging polymer. The photoresist composition is especially useful for forming material patterns on a semiconductor substrate using 193 nm (ArF) lithography.Type: GrantFiled: September 13, 2012Date of Patent: August 27, 2013Assignee: International Business Machines CorporationInventors: Sen Liu, Pushkara R. Varanasi
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Patent number: 8470197Abstract: A crosslinked polysulfide-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: [(CaH2a-)mG1(-CbH2bSx—)n?m]o[CcH2c-G2-CdH2dSy—]p[R]q wherein G1 is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; G2 is a saturated, divalent cyclic aliphatic group of valence 2 containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; each R independently is a selected from the group consisting of a hydrogen atom, monovalent hydrocarbon of up to 20 carbon atoms and a halogen atom; each occurrence of subscripts a, b, c, d, m, n, o, p, q, x and y independently is an integer wherein a is 2 to 6; b is 2 to 6; c is 1 to 6; d is 1 to 6; m is 1 or 2; n is 3 to 5; o is a positiveType: GrantFiled: October 30, 2008Date of Patent: June 25, 2013Assignee: Momentive Performance Materials Inc.Inventors: Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
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Publication number: 20130123514Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.Type: ApplicationFiled: May 27, 2011Publication date: May 16, 2013Applicant: GRAPHEA, INC.Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
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Patent number: 8080605Abstract: Polymer-filler coupling compounds with the formula B-A-Sx—N are claimed. In these compounds, B is an azaheterocyclic oxygen or sulfur containing moiety, or an allyltin moiety; Sx is a polysulfide, where x is between 2 and about 10; A is a linking atom or group that forms a bridge between B and Sx; and N is a blocking group. Sx can be a disulfide. N can be a conventional blocking group or other group such as -A-B. Methods for using the polymer-filler coupling compounds to modify polymers containing unsaturated carbon-carbon bonds and promote filler dispersion are also claimed. Additionally, vulcanizable rubber compositions containing the polymer-filler coupling compounds and methods for making vulcanized rubber compositions using the polymer-filler coupling compounds are also claimed.Type: GrantFiled: December 28, 2006Date of Patent: December 20, 2011Assignee: Bridgestone CorporationInventors: Yasuo Fukushima, William L. Hergenrother, Russell W. Koch
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Publication number: 20110124540Abstract: Described are multi-ring antioxidant products comprising at least one sulfur-bridged aromatic hydrocarbon compound substituted on at least one of its aromatic rings by at least one sterically hindered 3,5-dihydrocarbyl-4-hydroxybenzyl moiety. Such products have the formula: R—Sn—R[—S—R]m wherein each R is, independently, an aromatic hydrocarbon group having 6-12 carbon atoms, wherein m is 0-20, wherein n is 1-6 when m is 0, and when n is 1, m is 1-20; and wherein at least one of R, R1, and R2 is substituted by at least one such sterically hindered moiety. The preparation of such products and their use as antioxidants in compositions normally susceptible to oxidative degradation in oxygen or air, e.g., liquid fuel and lubricants, are also described.Type: ApplicationFiled: July 13, 2009Publication date: May 26, 2011Applicant: ALBEMARLE CORPORATIONInventor: Mahmood Sabahi
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Patent number: 7919635Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: February 6, 2009Date of Patent: April 5, 2011Assignee: UBE Industries, Ltd.Inventor: Teruo Umemoto
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Publication number: 20100204337Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: ApplicationFiled: April 22, 2010Publication date: August 12, 2010Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: Edward Turos, Praveen Ramaraju
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Publication number: 20100147770Abstract: A composition and process are described that provide for selective capture of targeted materials, including metals and chemical targets. The composition includes an activated carbon scaffold that is chemically modified to include ligands with a high affinity for selective capture of metals and chemical targets. The invention finds use, e.g., as heavy metal sorbents, as catalyst supports, in analytical applications such as ion chromatography, and in devices such as analytical instruments and chemical sensors.Type: ApplicationFiled: December 12, 2008Publication date: June 17, 2010Inventors: Glen E. Fryxell, William D. Samuels
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Publication number: 20090203924Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: ApplicationFiled: February 6, 2009Publication date: August 13, 2009Applicant: IM&T RESEARCH, INC.Inventor: TERUO UMEMOTO
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Patent number: 7501543Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: April 21, 2008Date of Patent: March 10, 2009Assignee: IM&T Research, Inc.Inventors: Teruo Umemoto, Rajendra Singh
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Publication number: 20080233606Abstract: Provided herein are assays for detecting enzyme activity using Raman Spectroscopy.Type: ApplicationFiled: April 22, 2008Publication date: September 25, 2008Inventors: Mustapha Haddach, Gregory S. Naeve
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Publication number: 20080221364Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: ApplicationFiled: April 21, 2008Publication date: September 11, 2008Applicant: IM&T RESEARCH, INC.Inventors: TERUO UMEMOTO, RAJENDRA P. SINGH
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Patent number: 7381846Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: GrantFiled: July 25, 2007Date of Patent: June 3, 2008Assignee: IM&T Research, Inc.Inventors: Teruo Umemoto, Rajendra P. Singh
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Publication number: 20080039660Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds. Finally, various intermediate compounds for use in preparing substituted phenylsulfur trifluorides are provided.Type: ApplicationFiled: July 25, 2007Publication date: February 14, 2008Applicant: IM&T RESEARCH, INC.Inventors: TERUO UMEMOTO, RAJENDRA P. SINGH
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Patent number: 7265247Abstract: Novel substituted phenylsulfur trifluorides that act as fluorinating agents are disclosed. Also disclosed are methods for their preparation and methods for their use in introducing one or more fluorine atoms into target substrate compounds.Type: GrantFiled: July 28, 2006Date of Patent: September 4, 2007Assignee: IM&T Research, Inc.Inventors: Teruo Umemoto, Yong Xu
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Patent number: 7045663Abstract: The invention provides enantiomers of ajoene and derivtives of Z(?)-ajoene. The derivative of Z(?)-ajoene are useful for modulating integrin-mediated functions, for treating disorders, diseases or conditions in which integrins play a role, and for treating tissues to improve their condition for a subsequent use, such as transplantation.Type: GrantFiled: July 10, 2001Date of Patent: May 16, 2006Assignee: Billings Pharmaceuticals, Inc.Inventors: John B. Davidson, Alexander V. Tatarintsev, Ali S. Turgiev, James K. Hildreth
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Patent number: 7018840Abstract: The present invention is directed, in part, to fluorescent metal sensors for detecting metal ions, and methods of making and using the same.Type: GrantFiled: April 17, 2002Date of Patent: March 28, 2006Assignee: Massachusetts Institute of TechnologyInventors: Stephen J. Lippard, Shawn Burdette
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Patent number: 6930128Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: July 10, 2003Date of Patent: August 16, 2005Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
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Patent number: 6809206Abstract: The method of this invention prepares acylated cyclic compounds by contacting phenyl esters as acylating agents with cyclic compounds in the presence of a cyanide or fluoride catalyst.Type: GrantFiled: March 24, 2003Date of Patent: October 26, 2004Assignee: E. I. du Pont de Nemours and CompanyInventor: Paul Walter Wojtkowski
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Publication number: 20040015019Abstract: In the process according to the invention for the manufacture of an alkanesulphonyl chloride RCH2—SO2Cl by oxidative chlorolysis of the corresponding mercaptan RCH2—SH, the mercaptan and water are introduced into the reaction mixture in the form of a dispersion of water in the mercaptan.Type: ApplicationFiled: July 25, 2003Publication date: January 22, 2004Inventors: Jean Ollivier, Gisele Haurat
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Patent number: 6656968Abstract: Compounds of the formula are provided wherein R1, R2, R3 and R4 are independently selected from the group consisting of hydrogen, halogen, hydroxyl, C1-C8 alkyl, C1-C6 alkoxy, nitro, cyano, acetoxy, amino, carboxy, sulfamyl, lower acylsulfamyl and trifluoromethyl. The compounds are inhibitors of cyclooxygenase-2 activity, useful for treating inflammation and cyclooxygenase-mediated disorders.Type: GrantFiled: December 17, 2001Date of Patent: December 2, 2003Assignee: Temple University - Of the Commonwealth System of Higher EducationInventors: E. Premkumar Reddy, M. V. Ramana Reddy
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Publication number: 20030220524Abstract: This invention is directed to novel and known stufur containing compounds and pharmaceutically acceptable salts thereof that have utility as antifungals and as antiproliferative agents against mammalian cells, in particular cancer cells and most particularly leukemia-derived cells. The invention provides a method for synthesizing certain of the sulfur containing compounds that is more efficient than previously known methods.Type: ApplicationFiled: January 21, 2003Publication date: November 27, 2003Inventors: Richard Francis Langler, Felix J Baerlocher, Linda Z Penn
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Publication number: 20030208006Abstract: A method is provided for making aromatic-imide and aromatic-methylidynetrissulfonyl species by reaction of aromatic species with a reactant according to formula (I):Type: ApplicationFiled: May 12, 2003Publication date: November 6, 2003Applicant: 3M Innovative Properties CompanyInventor: Steven Joseph Hamrock
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Publication number: 20030096189Abstract: Disclosed are novel onium salts represented by general formula (R) 3S+M, wherein three R's may be the same or different, each being an aryl group, provided that at least one of R's is a t-alkoxy substituted phenyl group, and M is an anion capable of foxing the sulfonium salts; and high energy radiation-responsive positive resist materials using said novel onium salts as acid generator.Type: ApplicationFiled: March 11, 1997Publication date: May 22, 2003Inventors: FUJIO YAGIHASHI, TOMOYOSHI FURIHATA, JUN WATANABE, AKINOBU TANAKA, YOSHIO KAWAI, TADAHITO MATSUA
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Patent number: 6555712Abstract: The present invention discloses a process for the preparation of a diorganotrisulfide said process by reacting an organic halide and elemental sulfur (&agr;-rhombic) using catalytic copper (II) halide and tin (II) halide in a mixture of organic solvents at 30-70° C.Type: GrantFiled: March 28, 2001Date of Patent: April 29, 2003Assignees: Indian Institute of Technology, Council of Scientific and Industrial ResearchInventors: Pradipta Sinha, Sujit Roy
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Patent number: 6492405Abstract: The present invention provides a compound containing at least one sulfhydryl group and at least one NO donor group, wherein said compound is a) a compound containing one or more sulfhydryl groups linked to at least one aromatic ring or a heteroaromatic ring with a nitrogen in the ring structure, which ring is substituted by one or more substituents bearing a terminal —ONO2 group; b) a 5-membered ring heterocyclic compound containing a sulfur atom and a nitrogen atom, which ring is substituted by one or more substituents bearing a terminal —ONO2 group; c) a 5-membered ring compound containing two conjugate S-atoms, which ring is linked to one or more substituents bearing a terminal —ONO2 group; or d) a compound containing an acyclic —S—S group, linked to at least one aromatic ring or a heteroaromatic ring with a nitrogen in the ring structure, which ring is substituted by one or more substituents bearing a terminal —ONO2 group.Type: GrantFiled: January 9, 2002Date of Patent: December 10, 2002Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventor: Abdullah Haj-Yehia
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Patent number: 6458506Abstract: This invention relates to new photoacid generator compounds and photoresist compositions that comprise such compounds. In particular, the invention relates to photoacid generator compounds that generate an anthracene acid upon exposure to activating radiation, particularly anthracene sulfonic acids such as acids that include 9,10-dialkoxyanthracene-2-sulfonate moieties. Positive- and negative-acting chemically amplified resists that contain such PAGs and that are imaged with I-line (365 nm) radiation are particularly preferred.Type: GrantFiled: August 13, 1999Date of Patent: October 1, 2002Assignee: Shipley Company, LLCInventor: James F. Cameron
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Patent number: 6452052Abstract: Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.Type: GrantFiled: January 31, 2002Date of Patent: September 17, 2002Assignee: Alcon Universal Ltd.Inventors: Mark R. Hellberg, Zixia Feng, Steven T. Miller
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Patent number: 6444853Abstract: This invention relates to a process for the preparation of aromatic disulfides represented by the formula (II): Yn—Ar—S—S—Ar—Yn (II) wherein Ar represents a hydrocarbon aromatic ring group; Y represents a monovalent electrophilic group, and when n is 2 or more, a plural number of Y's may be the same or different from each other; and n is an integer of 1 to 12, which comprises allowing (A) an aromatic thioether represented by the formula (I): Yn—Ar—S—R (I) wherein Y, Ar and n have the same meanings as defined above; and R represents a monovalent hydrocarbyl group selected from the group consisting of a monovalent tertiary hydrocarbyl group, and benzyl group and a monovalent secondary hydrocarbyl group derived from benzyl group; to react with (B) at least one of the following (1) to (4): (1) bromine; (2)(a) hydrogen bromide and (b) hydrogen peroxide; (3)(c) chlorine, in the presence of a catalytic amount of iodine and/or hydrType: GrantFiled: April 4, 2001Date of Patent: September 3, 2002Assignee: Nippon Finechemical Co., Ltd.Inventors: Isamu Arai, Tutomu Yamaguchi, Yoko Hida
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Publication number: 20020115728Abstract: The present invention relates to compositions and methods for prophylactic or therapeutic treatment of cardiovascular diseases, particularly restenosis and atherosclerosis. The invention further relates to compositions and methods for promoting re-endothelialization.Type: ApplicationFiled: September 5, 2001Publication date: August 22, 2002Inventor: Roland Stocker
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Publication number: 20020055039Abstract: A cathode active material and a lithium secondary battery employing the same are provided.Type: ApplicationFiled: June 26, 2001Publication date: May 9, 2002Inventors: Do-young Seung, Won-chel Jung, Chil-hoon Do, Sung-in Moon
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Patent number: 6372802Abstract: Methods and compositions for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The compositions contain a mast cell stabilizing disulfide derivative as an active ingredient.Type: GrantFiled: April 25, 2001Date of Patent: April 16, 2002Assignee: Alcon Universal Ltd.Inventors: Mark R. Hellberg, Zixia Feng, Steven T. Miller
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Patent number: 6294699Abstract: A process useful for producing an organic disulfide is disclosed. The process can include contacting mercaptans with a solid catalyst selected from the group consisting of a Group IIA metal oxide; 2) an alumina material consisting essentially of alumina; 3) an impregnated alumina impregnated with a metal selected from the group consisting of cobalt, molybdenum, tungsten, nickel and combinations of any two or more thereof; 4) an acidic ion-exchange resin; 5) a basic ion-exchange resin; and 6) combinations of any two or more thereof; in the presence of sulfur dioxide and in the substantial absence of a liquid oxidation catalyst to thereby produce organic disulfides.Type: GrantFiled: March 31, 2000Date of Patent: September 25, 2001Assignee: Richmond, Hitchcock, Fish & DollarInventors: Mitchell D. Refvik, James Edward Shaw
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Patent number: 6248883Abstract: Provided are methods of purification of an organic lithium salt comprising the steps of: (a) dissolving an impure organic lithium salt in a solution comprising an organic complexing solvent; (b) crystallizing from said solution a solid solvate complex comprising said lithium salt and said organic complexing solvent; (c) separating said solid solvate complex from said solution; (d) dissociating said solid solvate complex to yield: (i) said lithium salt in a solid form, and, (ii) a volatile composition comprising said organic complexing solvent; and, (e) removing said volatile composition to yield said lithium salt in a solid form of purity greater than the purity of said impure lithium salt. The present invention also pertains to electrolytes for electric current producing cells comprising such purified lithium salts.Type: GrantFiled: December 4, 1998Date of Patent: June 19, 2001Assignee: Moltech CorporationInventors: Alexander Gorkovenko, Grigorii L. Soloveichik
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Patent number: 6057120Abstract: The invention concerns the use of redox-active compounds for the production of detection reagents for a method for the determination of an analyte as well as reagent kits that contain these redox-active compounds. In addition new redox-active compounds are disclosed.Type: GrantFiled: September 22, 1997Date of Patent: May 2, 2000Assignee: Roche Diagnostics GmbHInventors: Dieter Heindl, Rupert Herrmann, Joachim Hones, Hans-Peter Josel, Martina Junius-Comer, Hartmut Merdes, Axel Schmidt, Ernst Selbertinger
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Patent number: 6013649Abstract: This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfone inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.Type: GrantFiled: July 22, 1997Date of Patent: January 11, 2000Assignee: Monsanto CompanyInventors: John N. Freskos, S. Zaheer Abbas, Gary A. DeCrescenzo, Daniel P. Getman, Robert M. Heintz, Brent V. Mischke, Joseph J. McDonald
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Patent number: 5998670Abstract: Disclosed is a method of making a substituted diphenyldisulfide from a substituted thiophenol. A two phase reaction mixture is prepared which comprises a substituted thiophenol having the general formula ##STR1## hydrogen peroxide, water, an organic solvent, a basic salt that will give a pH between about 7 and about 10, and an optional flocculating agent. In the formula, R is selected from the group consisting of halogen, alkyl from C.sub.1 to C.sub.6, alkoxy from C.sub.1 to C.sub.6, or nitro. After the exothermic reaction is complete, the reaction mixture is cooled to crystallize the substituted diphenyldisulfide product. The symmetrical product precipitates preferentially over the unsymmetrical product, thereby enhancing the purity of the product over the purity of the starting material. Optionally, the organic solvent and the aqueous phase are recycled.Type: GrantFiled: March 18, 1998Date of Patent: December 7, 1999Assignee: Occidental Chemical CorporationInventors: David Y. Tang, Michael C. Hausladen, Viktor D. Sorokin
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Patent number: 5846926Abstract: A novel class of nonionic gemini surfactants and methods for their preparation consist of compounds with three hydrophilic heads and two lipophilic tails of the general formula: ##STR1## wherein R.sub.1 and R.sub.3 independently represents a C.sub.1 to C.sub.22 straight or branched chain alkyl, alkylene, aryl or alkylaryl, or hydrogen, with the proviso that both cannot be hydrogen; R.sub.2 represents a C.sub.1 to C.sub.5 straight or branched chain alkyl, alkylene or hydrogen, (Y) represents ##STR2## wherein R.sub.4 represents C.sub.1 to C.sub.3 alkyl or hydrogen and may be the same or different; X represents --(CH.sub.2).sub.a -- wherein a is a whole number of from 1 to 5; --S--, --S--S--, --SO.sub.2, --(CH.sub.2).sub.a SO.sub.2 (CH.sub.2).sub.a --,--O--, --C.dbd.O, or --CH.sub.2 --NR--CH.sub.2 -- wherein R is a C.sub.1 to C.sub.3 straight or branched chain alkyl, alkylene or hydrogen and x, y, and z are whole numbers of from about 6 to about 300.Type: GrantFiled: June 9, 1997Date of Patent: December 8, 1998Assignee: Rhodia Inc.Inventors: David James Tracy, Ruoxin Li, Jiang Yang
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Modified phosphorous intermediates for providing functional groups on the 5' end of oligonucleotides
Patent number: 5786512Abstract: Phosphoramidites of the formula ##STR1## where R is a base-labile protecting group, R.sup.1 and R.sup.Type: GrantFiled: November 8, 1994Date of Patent: July 28, 1998Assignee: LaJolla Pharmaceutical CompanyInventors: David S. Jones, John P. Hachmann, Michael J. Conrad, Stephen Coutts, Douglas Alan Livingston -
Patent number: 5733909Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.Type: GrantFiled: January 21, 1997Date of Patent: March 31, 1998Assignee: Merck Frosst Canada, Inc.Inventors: Cameron Black, Mario Girard, Daniel Guay, Zhaoyin Wang
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Patent number: 5710256Abstract: The present invention is directed to novel methadone derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to methadone and methadone metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.Type: GrantFiled: April 3, 1995Date of Patent: January 20, 1998Assignee: Biosite Diagnostics IncorporatedInventor: Kenneth F. Buechler