Oxygen Containing Patents (Class 568/22)
  • Patent number: 10669598
    Abstract: The present invention provides processes for catalytically converting biomass to oxygenated compounds suitable for use in bioreforming processes.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: June 2, 2020
    Assignee: VIRENT, INC.
    Inventors: Ming Qiao, Randy D. Cortright, Dick A. Nagaki, Elizabeth Woods
  • Patent number: 10647676
    Abstract: This invention pertains to bivalent linkers, and the synthesis and use thereof. In particular, this invention pertains to the synthesis and use of bivalent linkers in preparing vitamin, drug, diagnostic agent, and/or imaging agent conjugates. The present invention includes divalent linkers, which are alternatively referred to as bivalent linkers, that may be used to couple, link, bond, attach, or otherwise associate two or more chemical entities. This coupling, linking, attachment, or association may be used in the formation of conjugates of such chemical entities. Those chemical entities include targeting ligands and receptor-binding ligands, such as vitamins. Those chemical entities also include drugs for treating various diseases or disease states, and imaging and diagnostic agents for diagnosing, detecting, or otherwise monitoring various diseases or disease states.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: May 12, 2020
    Assignee: Endocyte, Inc.
    Inventors: Iontcho R. Vlahov, Christopher P. Leamon, Apparao Satyam, Stephen J. Howard
  • Patent number: 9944879
    Abstract: The present invention provides phosphorous-containing compounds useful as antiwear additive components, lubricant additive compositions and lubricant compositions each comprising such compounds, and methods for making and using the same.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: April 17, 2018
    Assignee: Afton Chemical Corporation
    Inventors: David Edwards, Bevin Parks
  • Patent number: 9212328
    Abstract: The present invention includes improved systems and methods for producing biomass-derived feedstocks for biofuel and biochemical manufacturing processes. The systems and methods use components that are capable of transferring relatively high concentrations of solid biomass utilizing pressure variations between vessels, and allows for the recovery and recycling of heterogeneous catalyst materials.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: December 15, 2015
    Assignee: Virent, Inc.
    Inventors: John Kania, Ming Qiao, Elizabeth M. Woods, Randy D. Cortright, Paul Myren
  • Publication number: 20150147288
    Abstract: The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates to pesticide compounds and formulations that include terpenes or terpenoids having chemical formula of (C5H8)n, and its derivatives and analogs thereof, as active insecticidal ingredients; certain botanical essential oils as synergists, and other select ingredients as additives.
    Type: Application
    Filed: February 2, 2015
    Publication date: May 28, 2015
    Inventor: Tao Zhong
  • Patent number: 8962692
    Abstract: The present invention discloses cysteine prodrugs having the general formula: cystine dimers of the cysteine prodrugs having the general formula: protected cysteine analogs having the general formula: and dimers of the protected cysteine analogs having the general formula: The invention further encompasses pharmaceutical compositions containing the disclosed prodrugs, dimers, and analogs, and methods of using such compounds for treatment of schizophrenia and drug addiction.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: February 24, 2015
    Assignees: Marquette University, UWM Research Foundation, Inc.
    Inventors: James M. Cook, David A. Baker, Wenyuan Yin, Edward Merle Johnson, II
  • Publication number: 20150029577
    Abstract: A surfactant includes a hydrophobic functional group, a hydrophilic functional group and a linker disposed between the hydrophobic functional group and the hydrophilic functional group. The linker is connected to the hydrophobic functional group and the hydrophilic functional group. The linker has a cleavable bond with a bond energy lower than a bond energy of a bond included in the hydrophilic functional group and a bond included in the hydrophobic functional group.
    Type: Application
    Filed: October 6, 2014
    Publication date: January 29, 2015
    Inventors: Sung-Chan Jo, Jae-Cheol Park, Sang-Ji Park, Hye-Young Park, Yiying Jia, Min-Jeong Oh, Hee-June Kwak
  • Patent number: 8921028
    Abstract: A salt represented by the formula (I) and a resist composition containing the salt are provided, wherein Q1, Q2, L1, ring W1, Re1, Re2, Re3, Re4, Re5, Re6, Re7, Re8, Re9, Re10, Re11, Re12, Re13 and Z are defined in the specification.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: December 30, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Satoshi Yamaguchi, Koji Ichikawa
  • Patent number: 8906589
    Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which can have one or more fluorine atoms, R3 represents a hydrogen atom or a methyl group, and Z1+ represents an organic counter cation, and a photoresist composition containing the same.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: December 9, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Hiromu Sakamoto
  • Publication number: 20140329267
    Abstract: It is provided a self-healing polymer network comprising transition metal thiolates, particularly thiolates of a transition metal that is able to self-assemble by metallophilic attractions, and more particularly Au(1), Ag(1), Cu(1) thiolates, or a mixture thereof, and, optionally, disulfide bonds, thiol and other thiolate groups. It is also provided several processes for the preparation of the self-healing polymer networks of the invention, as well as uses thereof.
    Type: Application
    Filed: November 27, 2012
    Publication date: November 6, 2014
    Inventors: Ibón Odriozola, Pablo Casuso, Natividad Díaz, Iraida Loinaz, Germán Cabañero, Hans-jürgen Grande
  • Patent number: 8877830
    Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material or during polymerization of a polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides mixtures for making crosslinked polymeric materials, methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention. The mixtures of the invention may be dental restorative compositions used for forming dental restorative materials.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 4, 2014
    Assignee: The Regents of the University of Colorado, A Body Corporate
    Inventors: Christopher N. Bowman, Christopher Kloxin, Hee Young Park, Diana Leung
  • Publication number: 20140323562
    Abstract: The present application provides compound of Formula X wherein A is an optionally substituted aliphatic or an optionally substituted aryl, and B is a moiety that stabilizes the partial positive charge at the carbon adjacent the divalent sulfur. The compound of Formula X is useful as a reversible antioxidant in a variety of applications. Also provided are methods of synthesizing the compound of Formula X.
    Type: Application
    Filed: November 23, 2012
    Publication date: October 30, 2014
    Inventors: Philip Jessop, Paul David Thornton, Shannon Marie Decker, Derek Pratt, Feng Zheng, Donna Lynn Leger
  • Patent number: 8765352
    Abstract: A positive resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under the action of acid and an acid-generator component (B) which generates acid upon exposure, wherein the acid-generator component (B) includes an acid generator (B1) containing a compound represented by general formula (b1-1) shown below (wherein Z+ represents an organic cation).
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: July 1, 2014
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Yoshiyuki Utsumi, Takehiro Seshimo
  • Patent number: 8741545
    Abstract: The present invention relates to a fluorine-free photoacid generator (PAG) and a photoresist composition containing the same. The PAG is characterized by the presence of an onium cationic component and a fluorine-free fused ring heteroaromatic sulfonate anionic component containing one or more electron withdrawing substituents. The onium cationic component of the PAG is preferably a sulfonium or an iodonium cation. The photoresist composition further contains an acid sensitive imaging polymer. The photoresist composition is especially useful for forming material patterns on a semiconductor substrate using 193 nm (ArF) lithography.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 3, 2014
    Assignee: International Business Machines Corporation
    Inventors: Sen Liu, Pushkara R. Varanasi
  • Publication number: 20140142227
    Abstract: The present invention relates to silica-containing rubber mixture produced from at least one rubber, from a sulphur-containing alkoxysilane, from a crosslinking agent, from a filler, and optionally from further rubber auxiliaries, where the said mixture comprises from 0.
    Type: Application
    Filed: April 27, 2012
    Publication date: May 22, 2014
    Applicant: LANXESS Deutschland GmbH
    Inventors: Melanie Wiedemeier, Hermann-Josef Weidenhaupt, Ulrich Feldhues, Irene Moll
  • Patent number: 8709700
    Abstract: The present invention relates to a fluorine-free photoacid generator (PAG) and a photoresist composition containing the same. The PAG is characterized by the presence of an onium cationic component and a fluorine-free fused ring heteroaromatic sulfonate anionic component containing one or more electron withdrawing substituents. The onium cationic component of the PAG is preferably a sulfonium or an iodonium cation. The photoresist composition further contains an acid sensitive imaging polymer. The photoresist composition is especially useful for forming material patterns on a semiconductor substrate using 193 nm (ArF) lithography.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: April 29, 2014
    Assignee: International Business Machines Corporation
    Inventors: Sen Liu, Pushkara R. Varanasi
  • Patent number: 8658833
    Abstract: A method of producing polysulfides comprising the step of adding elemental sulphur to an allicin-containing plant extract. In preferred embodiments, the plant extract is mechanically treated members of the genus Allium, especially garlic. In further preferred aspects of the invention, the plant extract and sulphur mixture is heated, and the pH is controlled to allow manipulation of the polysulfide chain length. The addition of organic bases, containing nitrogen lone pairs, allows further control of polysulfide chain length.
    Type: Grant
    Filed: November 9, 2007
    Date of Patent: February 25, 2014
    Assignee: Ecospray Limited
    Inventors: Eric Block, Murree Groom
  • Publication number: 20140046097
    Abstract: Process for the preparation of polysulfide of formula (I) HS—(CH2)n—O—(CH2)m—O—(CH2)p—[S—S—CH2)nO—(CH2)m—O—(CH2)p]q-SH (I) wherein m is an integer in the range 1 to 4, n and p are integers in the range 1-10, and q is an integer in the range 1-60, by oxidizing a bismercaptodiether compound of formula (II) HS—(CH2)n—O—(CH2)m—O—(CH2)p—SH (II) with elemental sulfur in the presence of a base and a protic solvent. This process has a high selectivity towards linear disulfides.
    Type: Application
    Filed: April 10, 2012
    Publication date: February 13, 2014
    Applicants: SHANGHAI ICI RESEARCH 7 DEVELOPMENT & MANAGEMENT CO. LTD, AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Olaf Klobes, Jing He
  • Patent number: 8642755
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The methods employ a phenylacetyl disulfide reagent (known as PADS), phenylthioacetic acid (PTAA) in the presence or absence or N-alkyl imidazole in industrially preferred solvents or solvents that are derived from renewable resources. The use of PTAA eliminates the need to “age” the PADS solution prior to its use in sulfurization reactions.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: February 4, 2014
    Assignee: Agilent Technologies, Inc.
    Inventors: Agnieszka B. Sierzchala, Douglas J Dellinger, Victor R Mokler, Zoltan Timar
  • Patent number: 8642813
    Abstract: The present invention provides methods, reactor systems, and catalysts for converting in a continuous process biomass to less complex oxygenated compounds for use in downstream processes to produce biofuels and chemicals. The invention includes methods of converting the components of biomass, such as hemicellulose, cellulose and lignin, to water-soluble materials, including lignocellulosic derivatives, cellulosic derivatives, hemicellulosic derivatives, carbohydrates, starches, polysaccharides, disaccharides, monosaccharides, sugars, sugar alcohols, alditols, polyols, diols, alcohols, ketones, cyclic ethers, esters, carboxylic acids, aldehydes, and mixtures thereof, using hydrogen and a heterogeneous liquefaction catalyst.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: February 4, 2014
    Assignee: Virent, Inc.
    Inventors: Ming Qiao, Randy D. Cortright, John Kania, Elizabeth Woods
  • Patent number: 8623923
    Abstract: A process for the preparation of ajoene, and of ajoene having a relatively high purity which may be obtained by the process. This invention also relates to processes for the preparation of allicin, and to a process for freeze concentrating allicin.
    Type: Grant
    Filed: March 2, 2010
    Date of Patent: January 7, 2014
    Assignee: Neem Biotech Limited
    Inventors: David Michael Williams, Robert Alun Saunders, Gareth James Street Evans
  • Publication number: 20130336916
    Abstract: The invention generally relates to environmental friendly pesticide compounds, formulations, methods of preparation and application and utilities thereof. More particularly, the invention relates to pesticide compounds and formulations that include terpenes or terpenoids having chemical formula of (C5H8)n, and its derivatives and analogs thereof, as active insecticidal ingredients; certain botanical essential oils as synergists, and other select ingredients as additives.
    Type: Application
    Filed: June 18, 2012
    Publication date: December 19, 2013
    Inventor: Tao Zhong
  • Patent number: 8470197
    Abstract: A crosslinked polysulfide-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: [(CaH2a-)mG1(-CbH2bSx—)n?m]o[CcH2c-G2-CdH2dSy—]p[R]q wherein G1 is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; G2 is a saturated, divalent cyclic aliphatic group of valence 2 containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]r group of valence n; each R independently is a selected from the group consisting of a hydrogen atom, monovalent hydrocarbon of up to 20 carbon atoms and a halogen atom; each occurrence of subscripts a, b, c, d, m, n, o, p, q, x and y independently is an integer wherein a is 2 to 6; b is 2 to 6; c is 1 to 6; d is 1 to 6; m is 1 or 2; n is 3 to 5; o is a positive
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: June 25, 2013
    Assignee: Momentive Performance Materials Inc.
    Inventors: Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
  • Publication number: 20130123514
    Abstract: The disclosure relates to catalytically active carbocatalysts, e.g., a graphene oxide or graphite oxide catalyst suitable for use in a variety of chemical transformations. In one embodiment, it relates to a method of catalyzing a chemical reaction of an organic molecule by reacting the organic molecule in the presence of a sufficient amount of graphene oxide or graphite oxide for a time and at a temperature sufficient to allow catalysis of a chemical reaction. According to other embodiments, the reaction may be an oxidation reaction, a hydration reaction, a dehydrogenation reaction, a condensation reaction, or a polymerization reaction. Some reactions may include auto-tandem reactions. The disclosure further provides reaction mixtures containing an organic molecule and graphene oxide or graphite oxide in an amount sufficient to catalyze a reaction of the organic molecule.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 16, 2013
    Applicant: GRAPHEA, INC.
    Inventors: Christopher W. Bielawski, Daniel R. Dreyer, Hong-Peng Jia
  • Patent number: 8404758
    Abstract: The invention provides methods for inducing reversible chain cleavage of polymer chains in a crosslinked polymeric material. Reversible cleavage of the polymer backbone is capable of relieving stress in the polymeric material as the bonds reform in a less stressed state. The invention also provides methods for making polymeric materials capable of reversible chain cleavage, materials made by the methods of the invention, and linear monomers containing reversible chain cleavage groups which are useful in the materials and methods of the invention.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: March 26, 2013
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Christopher N. Bowman, Timothy F. Scott
  • Publication number: 20130057940
    Abstract: A surfactant includes a hydrophobic functional group, a hydrophilic functional group and a linker disposed between the hydrophobic functional group and the hydrophilic functional group, and the linker is connected to the hydrophobic functional group and the hydrophilic functional group. The linker has a cleavable bond with a bond energy lower than a bond energy of a bond included in the hydrophilic functional group and a bond included in the hydrophobic functional group.
    Type: Application
    Filed: September 6, 2012
    Publication date: March 7, 2013
    Inventors: Sung-Chan JO, Jae-Cheol Park, Sang-Ji Park, Hye-Young Park, Yiying Jia, Min-Jeong Oh, Hee-June Kwak
  • Publication number: 20130041183
    Abstract: The invention related to a process for the preparation of a bismercaptodiether by reacting a polysulfide with a monothiol in the presence of a base and to a process for the depolymerization of a polysulfide by reacting said polysulfide with a monothiol in the presence of a base. These processes enable the preparation of bismercaptodiethers without inorganic salt formation.
    Type: Application
    Filed: March 14, 2011
    Publication date: February 14, 2013
    Applicant: AKZO NOBEL CHEMICALS INTERNATIONAL B.V.
    Inventors: Rudolf Anthonius Maria Venderbosch, Hendrika Petronella Maria Verlaan-Hooft, Auke Gerardus Talma, Olaf Klobes, Ralf Tatas, Hendrik Jan Vos
  • Patent number: 8357723
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 22, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Patent number: 8354455
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 15, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Patent number: 8349901
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: January 8, 2013
    Assignee: Piramal Enterprises Limited and Apparao Satyam
    Inventor: Apparao Satyam
  • Publication number: 20120329744
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Application
    Filed: June 25, 2012
    Publication date: December 27, 2012
    Inventors: William A. Garland, Brian D. Frenzel
  • Patent number: 8338643
    Abstract: The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: (wherein in formula (I)-1: L is a single bond, —CONH—, or —S—S—; M1 is —(CH2)k— or —(CH2CH2O)k— (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: December 25, 2012
    Assignee: Waseda University
    Inventors: Shinji Takeoka, Naoya Takeda, Hitoshi Kurumizaka, Isao Sakane, Namiko Ikegaya, Yosuke Obata, Syunsuke Saito
  • Patent number: 8334340
    Abstract: A sulfur-containing cycloaliphatic compound, useful as a crosslinker for filled sulfur-vulcanizable elastomer compositions, is represented by the general formula: G[—CaH2a—S—S(?O)b—R]n wherein G is a saturated, monocyclic aliphatic group of valence n containing from 5 to 12 carbon atoms and optionally containing at least one halogen or a saturated monocyclic silicone [RSiO—]n[R2SiO—]p group of valence n; each R independently is a monovalent hydrocarbon of up to 20 carbon atoms; each occurrence of subscripts a and b independently is an integer wherein a is 2 to 6 and b is 1 or 2; n is an integer of from 3 to 6; and p is an integer of from 0 to 3.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: December 18, 2012
    Assignee: Momentive Performance Materials, Inc.
    Inventors: Michael Joseph O'Brien, Robert James Perry, Richard W. Cruse, William Michael York, Carla Recker, Thomas Kramer, Katharina Herzog
  • Patent number: 8309710
    Abstract: A method and compositions for sulfurizing at least one phosphite or thiophosphite linkage in an oligonucleotide. The addition of N-alkyl imidazole to the acetyldisulfide sulfurization solution enables the use of industrially preferred solvents or solvents that are derived from renewable resources.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: November 13, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Agnieszka B. Sierzchala, Douglas J Dellinger, Paul A. Metz, Victor R Mokler
  • Publication number: 20120282334
    Abstract: Disclosed is a method for preparing ajoene including: (a) obtaining garlic pulp or garlic extract from garlic; (b) mixing the garlic pulp or garlic extract with animal lipid to form a reaction mixture; and (c) heating the reaction mixture to obtain ajoene. The ajoene prepared according to the present disclosure may be encapsulated with gelatin. According to the present disclosure, ajoene can be prepared with a yield 2 times or more than that of the existing methods. Thus, ajoene can be provided as active ingredient for foods and medicines more cost-effectively. Also, the production protocol according to the present disclosure is suitable for large-scale production of ajoene.
    Type: Application
    Filed: November 7, 2011
    Publication date: November 8, 2012
    Applicant: KOREA FOOD RESEARCH INSTITUTE
    Inventors: Dong Bin Shin, Mi Young Yoo, Ho Moon Seog, Jae Ho Ha, Sang Hee Lee, Yong Sun Cho
  • Patent number: 8227517
    Abstract: Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 24, 2012
    Assignee: Tosk, Incorporated
    Inventors: William A. Garland, Brian D. Frenzel
  • Patent number: 8202997
    Abstract: A method for treating or preventing injury of a biological material exposed to hypoxic or ischemic conditions comprising contacting the biological material with an effective amount of a compound is disclosed. The compound has the following structure (I): R1—(S)n—R2 ??(I) or a stereoisomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, and n are as defined herein. Compounds, methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: June 19, 2012
    Assignee: Ikaria, Inc.
    Inventors: Edward A. Wintner, Fuqiang Ruan
  • Publication number: 20120148690
    Abstract: A novel skin barrier function recovery acceleration method and accelerator are provided. The present invention provides a skin barrier function recovery accelerator that comprises a TRPA1 agonist capable of activating TRPA1 in epidermal cells.
    Type: Application
    Filed: December 10, 2010
    Publication date: June 14, 2012
    Inventors: Mitsuhiro Denda, Moe Tsutsumi, Sumiko Denda
  • Publication number: 20120149940
    Abstract: 1,5-Dithiaocta-2,7-diene-5-oxide-1-yl (DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators that modulate integrin-mediated functions and/or processes. Pharmaceutical compositions containing integrin modulators and chiral enantiomers thereof, and methods for using integrin modulators and chiral enantiomers thereof are further described.
    Type: Application
    Filed: February 13, 2012
    Publication date: June 14, 2012
    Inventors: John B. Davidson, Ali S. Turgiev
  • Publication number: 20120070404
    Abstract: The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in the time of survival in cancer patients, wherein the cancer: (i) overexpresses thioredoxin or glutaredoxin and/or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and/or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth “aggressiveness” of the particular cancer and treatment responsiveness of the particular type of cancer.
    Type: Application
    Filed: September 16, 2010
    Publication date: March 22, 2012
    Inventor: Frederick H. Hausheer
  • Publication number: 20120053300
    Abstract: The invention relates to functionalized polysulfide silica coupling agents and silica reinforced rubber compositions. Such rubber composition may be used, for example, for tire components such as, for example, tire treads.
    Type: Application
    Filed: July 6, 2011
    Publication date: March 1, 2012
    Inventors: Junling Zhao, Michael Joseph Rachita
  • Patent number: 8101802
    Abstract: Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
    Type: Grant
    Filed: November 12, 2007
    Date of Patent: January 24, 2012
    Assignee: ECOspray Limited
    Inventors: Murree Groom, Eric Block
  • Publication number: 20110319496
    Abstract: A process for the preparation of ajoene, and of ajoene having a relatively high purity which may be obtained by the process. This invention also relates to processes for the preparation of allicin, and to a process for freeze concentrating allicin.
    Type: Application
    Filed: March 2, 2010
    Publication date: December 29, 2011
    Applicant: NEEM BIOTECH LIMITED
    Inventors: David Michael Williams, Robert Alun Saunders, Gareth James Street Evans
  • Patent number: 8080605
    Abstract: Polymer-filler coupling compounds with the formula B-A-Sx—N are claimed. In these compounds, B is an azaheterocyclic oxygen or sulfur containing moiety, or an allyltin moiety; Sx is a polysulfide, where x is between 2 and about 10; A is a linking atom or group that forms a bridge between B and Sx; and N is a blocking group. Sx can be a disulfide. N can be a conventional blocking group or other group such as -A-B. Methods for using the polymer-filler coupling compounds to modify polymers containing unsaturated carbon-carbon bonds and promote filler dispersion are also claimed. Additionally, vulcanizable rubber compositions containing the polymer-filler coupling compounds and methods for making vulcanized rubber compositions using the polymer-filler coupling compounds are also claimed.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 20, 2011
    Assignee: Bridgestone Corporation
    Inventors: Yasuo Fukushima, William L. Hergenrother, Russell W. Koch
  • Publication number: 20110306531
    Abstract: Novel sulfur-containing compositions comprise a polyether polysulfide or an ether polysulfide. The polyether polysulfide may be based upon an alkoxylate (an alcohol or glycol-initiated compound) that is a copolymer of at least two of ethylene oxide, propylene oxide and butylene oxide. The polyether polysulfide may alternatively be based upon a homopolymer of ethylene oxide, propylene oxide or butylene oxide. The ether polysulfide may be based upon a methoxy-capped polyglycol or an alkyl ether of 1,3-dichloro-2-propanol.
    Type: Application
    Filed: June 3, 2011
    Publication date: December 15, 2011
    Inventors: Yang Cheng, Cynthia L. Rand, John B. Cuthbert
  • Publication number: 20110269709
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Application
    Filed: December 23, 2010
    Publication date: November 3, 2011
    Inventor: Apparao Satyam
  • Publication number: 20110190368
    Abstract: Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumour cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.
    Type: Application
    Filed: August 5, 2009
    Publication date: August 4, 2011
    Applicant: University of Cape Town
    Inventors: Catherine Hart Kaschula, Roger Hunter, Mohamed Iqbal Parker
  • Patent number: 7932294
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: April 26, 2011
    Assignees: Apparao Satyam, Piramal Life Sciences Limited
    Inventor: Apparao Satyam
  • Publication number: 20100274037
    Abstract: Diallylic polysulfides (polysulfanes) are provided with sulfur chain lengths of 9 to 22. Also provided are bis(2-methyl-2-propenyl) polysulfides with sulfur chain lengths of 3 to 22. Also provided are 2-substituted bis(2-propenyl) polysulfides with sulfur chain lengths of 3 to 20. Also provided are the 2-cycloalken-1-yl polysulfides, 2-cyclohexen-1-yl polysulfides and 2-cyclopenten-1-yl polysulfides, with sulfur chain lengths of 3 to 20. Also provided are processes for extending the sulfur chain length of diallylic polysulfides and 2-substituted analogues thereof and allyl methyl polysulfides by bringing such compounds into contact with elemental sulfur and heating, or by mixing with molten sulfur.
    Type: Application
    Filed: November 12, 2007
    Publication date: October 28, 2010
    Inventors: Murree Groom, Eric Block
  • Publication number: 20100204337
    Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.
    Type: Application
    Filed: April 22, 2010
    Publication date: August 12, 2010
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Edward Turos, Praveen Ramaraju