Sulfur, Oxygen, Halogen Or Group Ia Or Iia Light Metal Containing Patents (Class 568/6)
  • Patent number: 9815856
    Abstract: The invention provides methods for preparing boronic acids, for example, primary alkyl or alkenyl boronic acids, and alkali metal alkyl trifluoro borate salts, as described herein, wherein the primary alkyl boronic acids and the potassium alkyl trifluoroborate salts can contain one or more unprotected functional groups.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: November 14, 2017
    Assignee: San Diego State University Research Foundation
    Inventors: Thomas E. Cole, Gloria Hincapie, Stewart C. Polk, David Zillman
  • Patent number: 9771380
    Abstract: Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: September 26, 2017
    Assignee: University of Oregon
    Inventors: James E. Hutchison, Edward W. Elliott, III, Zachary Kennedy, Patrick Haben
  • Patent number: 9663420
    Abstract: A method of preparing a cyclopropane ring-bearing compound of the formula I in which R1 and R2 are independently selected from C1-C10 alkyl, optionally substituted, or R1 and R2, together with the bonds linking them to the cyclopropane ring, form a monocyclic or bicyclic ring system, which may comprise at least one hetero-atom, comprising the reaction of a compound of formula II R1—CH?CH—R2??II in which R1 and R2 have the significances hereinabove defined, with a compound of formula III X—CH2—Y??III in which X is a nucleofuge selected from halides and pseudohalides and Y is an electrofuge selected from boranes and borates, in the presence of a metal catalyst complex selected from those useful for catalytic cyclopropanation and those useful for catalyzing Heck coupling. The method provides a particularly easy and non-hazardous method of cyclopropanation.
    Type: Grant
    Filed: November 6, 2014
    Date of Patent: May 30, 2017
    Assignee: ETH Zurich
    Inventors: Juan Manuel Sarria Toro, Peter Chen, Tim Den Hartog
  • Patent number: 9328127
    Abstract: A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: May 3, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Eric P. Gillis
  • Patent number: 9260456
    Abstract: The invention relates to a process for preparing metal difluorochelatoborates, in which a metal bis(chelato)borate of the formula M[BL2] is reacted with boron trifluoride and a metal fluoride (MF) and/or a metal salt of the chelating ligand (M2L) where M+ is a monovalent cation selected from the group consisting of lithium, sodium, potassium and ammonium NR4+, where R?H, alkyl (C1 to C8) and L is a chelating agent having two terminal oxygen atoms and having the general formula (II), where: when m=1 and Y1 and Y2 together with C1 form a carbonyl group, n=0 or 1 and o=0 or 1 and R1 and R2 are each, independently of one another, H or alkyl having from one to eight carbon atoms (C1-C8) and Y3, Y4 are each, independently of one another, OR3 (R3?C1-C8-alkyl), then n or o?1: p=0 or 1 and when n and o=0, p=1; or Y1, Y2, Y3, Y4 are each, independently of one another, OR3 (R3?C1-C8-alkyl), m=1, n=0 or 1, o=1 and p=0; or C2 and C3 are members of a 5- or 6-membered aromatic or heteroaromatic ring (with N, O or S as heter
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 16, 2016
    Assignee: Rockwood Lithium GmbH
    Inventors: Ulrich Wietelmann, Peter Rittmeyer, Ute Emmel
  • Publication number: 20150133691
    Abstract: In a reaction in which a boron trifluoride complex is used as a catalyst, the expensive and harmful boron trifluoride complex is separated from a reaction mixture containing the boron trifluoride complex by separating the boron trifluoride complex present in the reaction mixture by using a saturated hydrocarbon-based solvent.
    Type: Application
    Filed: March 1, 2013
    Publication date: May 14, 2015
    Applicant: IDEMITSU KOSAN CO., LTD.
    Inventors: Sumihiro Oda, Masashi Machida, Hiroki Sekiguchi, Yukio Yoshida, Toshiyuki Tsubouchi
  • Publication number: 20150119580
    Abstract: Boronic esters and boronic acids are synthesized at ambient temperature in an ethereal solvent by the reaction of Grignard reagents with a boron-containing substrate. The boron-containing substrate may be a boronic ester such as pinacolborane, neopentylglycolborane, or a dialkylaminoborane compound such as diisopropylaminoborane. The Grignard reagents may be pre-formed or generated from an alkyl, alkenyl, aryl, arylalkyl, heteroaryl, vinyl, or allyl halide compound and Mg0. When the boron-containing substrate is a boronic ester, the reactions generally proceed at room temperature without added base in about 1 to 3 hours to form a boronic ester compound. When the boron-containing substrate is a dialkylaminoborane compound, the reactions generally proceed to completion at 0° C. in about 1 hour to form a boronic acid compound.
    Type: Application
    Filed: July 20, 2012
    Publication date: April 30, 2015
    Applicant: The Regents of the University of California
    Inventors: Jacob W. Clary, Bakthan Singaram
  • Publication number: 20150105562
    Abstract: The present invention relates to a method for preparing borinic acid derivatives and novel borinic acid derivatives. The preparing method of the present invention provides borinic acid derivatives of general formula (2): (Ar?2B(OH) ??(2) wherein Ar is the same as defined in the description and claims, selectively and in a high yield by reacting a compound of general formula (1): Ar-M, ??(1) wherein Ar and M are the same as defined in the description and claims, with tri-t-butyl borate and then hydrolyzing the reaction product.
    Type: Application
    Filed: August 19, 2013
    Publication date: April 16, 2015
    Applicant: MANAC INC.
    Inventors: Satoshi Murakami, Takayuki Suzuki
  • Patent number: 9000206
    Abstract: The present invention provides a process for preparing triorgano borates with low alcohol content.
    Type: Grant
    Filed: February 16, 2011
    Date of Patent: April 7, 2015
    Assignee: BASF SE
    Inventors: Ronald J. Orosz, David F. Rouda, Karl Matos
  • Patent number: 8946452
    Abstract: A crystalline, completely soluble lithium bis(oxalato)horate (LiBOB), to a method for producing the same and to the use of the lithium bis(oxalato)borate.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: February 3, 2015
    Assignee: Chemetall GmbH
    Inventors: Rainer Dietz, Ulrich Wietelmann, Uwe Lischka, Thorsten Buhrmester, Klaus Schade
  • Publication number: 20140335406
    Abstract: A non-aqueous organic electrolyte additive is formulated by Formula (I), where R is halogen or R is one of: a C1-C10 alkyl group, a C1-C10 alkene group, a C1-C10 alkyne group, a C1-C10 alkoxy group, a halogen-containing C1-C10 alkyl group, a halogen-containing C1-C10 alkene group, a halogen-containing C1-C10 alkyne group and a halogen-containing C1-C10 alkoxy group. The non-aqueous organic electrolyte additive is oxidized and decomposed before an organic solvent in a high-voltage lithium-ion secondary battery, thereby forming a protection film that facilitates conduction of Li+ on a surface of an anode active material, increasing cyclic performance of a lithium-ion secondary battery at a high voltage, and achieving good stability. Embodiments of the present application further provide a method for preparing a non-aqueous organic electrolyte additive, a non-aqueous organic electrolyte containing the non-aqueous organic electrolyte additive, and a lithium-ion secondary battery having a high energy density.
    Type: Application
    Filed: July 24, 2014
    Publication date: November 13, 2014
    Inventor: Weifeng An
  • Publication number: 20140288331
    Abstract: The invention relates to a process for preparing metal difluorochelatoborates, in which a metal bis(chelato)borate of the formula M[BL2] is reacted with boron trifluoride and a metal fluoride (MF) and/or a metal salt of the chelating ligand (M2L) where M+ is a monovalent cation selected from the group consisting of lithium, sodium, potassium and ammonium NR4+, where R?H, alkyl (C1 to C8) and L is a chelating agent having two terminal oxygen atoms and having the general formula (II), where: when m=1 and Y1 and Y2 together with C1 form a carbonyl group, n=0 or 1 and o=0 or 1 and R1 and R2 are each, independently of one another, H or alkyl having from one to eight carbon atoms (C1-C8) and Y3, Y4 are each, independently of one another, OR3 (R3?C1-C8-alkyl), then n or o?1: p=0 or 1 and when n and o=0, p=1; or Y1, Y2, Y3, Y4 are each, independently of one another, OR3 (R3?C1-C8-alkyl), m=1, n=0 or 1, o=1 and p=0; or C2 and C3 are members of a 5- or 6-membered aromatic or heteroaromatic ring (with N, O or S as heter
    Type: Application
    Filed: November 14, 2012
    Publication date: September 25, 2014
    Inventors: Ulrich Wietelmann, Peter Rittmeyer, Ute Emmel
  • Publication number: 20140259230
    Abstract: A method of controlling phytopathogenic diseases on useful plants or plant propagation material thereof, which comprises applying to said plant or plant propagation material a fungicidally effective amount of a compound of formula (I) wherein all the substituent save indicated as in claim 1.
    Type: Application
    Filed: October 8, 2012
    Publication date: September 11, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Carla Bobbio, Christophe Weider, Ronald Zeun, Ramya Rajan, Daniel Stierli
  • Patent number: 8822633
    Abstract: Luminescent polymers having sterically twisted arylene repeat units are provided, which are particularly suited as electroluminescent polymers. Monomers necessary for the synthesis of the sterically twisted polyarylene are provided, as are electroluminescent device utilizing these polymers.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: September 2, 2014
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Matthew L. Marrocco, Virgil J. Lee, Farshad J. Motamedi
  • Publication number: 20140227184
    Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
    Type: Application
    Filed: August 20, 2012
    Publication date: August 14, 2014
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Wei Liu, Xiongyi Huang
  • Publication number: 20140187789
    Abstract: There is provided a novel process for the preparation of a compound of formula (I), (Formula (I)). There is also provided novel processes to intermediates of the compound of formula (I), as well as novel intermediates themselves.
    Type: Application
    Filed: July 20, 2012
    Publication date: July 3, 2014
    Applicant: CAMBREX KARLSKOGA AB
    Inventors: Lars Eklund, Lars Hansson, Tommy Lundholm, Pär Holmberg, Margus Eek
  • Publication number: 20140182680
    Abstract: The present invention relates to electrolyte formulations comprising at least one compound comprising a dihydridodicyanoborate anion and their use in an eletrochemical and/or optoelectronic device such as a photovoltaic cell, a light emitting device, an electrochromic or photo-electrochromic device, an electrochemical sensor and/or biosensor, preferably their use in a dye or quantum dot sensitized solar cell.
    Type: Application
    Filed: May 23, 2012
    Publication date: July 3, 2014
    Applicant: MERCK PATENT GMBH
    Inventors: Kentaro KAWATA, Tomohisa GOTO, Nikolai (Mykola) IGNATYEV, Michael SCHULTE, Hiroki YOSHIZAKI, Eduard BERNHARDT, Vera BERNHARDT-PITCHOUGINA, Helge WILLNER
  • Publication number: 20140175292
    Abstract: Tritiated planar carbon forms and their production are provided. Methods are provided for the stoichiometrically controlled labeling of planar carbon forms capitalizing on normal flaws of carboxylic acids ubiquitously present in commercial preparations of these planar carbon forms. Alternative methods include generation of a metallated intermediate whereby a metal is substituted for hydrogen on the carbon backbone of a planar carbon form. The metalized intermediate is then reacted with a tritium donor to covalently label the planar carbon form. The tritiated planar carbon forms produced are useful, for example, for determination of a biological property or environmental fate of planar carbon forms.
    Type: Application
    Filed: February 26, 2014
    Publication date: June 26, 2014
    Applicant: PerkinElmer Health Sciences, Inc.
    Inventor: Crist N. Filer
  • Patent number: 8754251
    Abstract: Provided are protected cyclopropylboronic acids that include a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is a pinene-derived iminodiacetic acid (PIDA) group or PIDA-based group.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: June 17, 2014
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Matthew Duncton, Martin D. Burke
  • Publication number: 20140155421
    Abstract: The present invention relates to substituted pyrimidinyl-pyrrole compounds of formula (I) which modulate the activity of protein kinases and are therefore useful in treating diseases caused by dysregulated protein kinase activity, in particular Janus kinases. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such compounds or the pharmaceutical compositions containing them.
    Type: Application
    Filed: April 5, 2012
    Publication date: June 5, 2014
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Maria Gabriella Brasca, Tiziano Bandiera, Jay Aaron Bertrand, Paola Gnocchi, Danilo Mirizzi, Marcella Nesi, Achille Panzeri
  • Patent number: 8722916
    Abstract: This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: May 13, 2014
    Assignee: Rigel Pharmaceuticals, Inc.
    Inventors: Matthew Duncton, Rajinder Singh
  • Publication number: 20140121142
    Abstract: A lubricating oil additive composition comprising the reaction product of an (a) an alkylated aromatic ether alcohol, (b) a source of boron, and (c) a hydrocarbyl polyol, having at least two hydroxyl groups.
    Type: Application
    Filed: October 30, 2012
    Publication date: May 1, 2014
    Applicant: Chevron Oronite Company LLC
    Inventor: Yat Fan Suen
  • Publication number: 20140113203
    Abstract: Electrolyte additives are described that enhance cycling stability of electrolytes and lithium composite electrodes that prolong cycling lifetimes and improve electrochemical performance of lithium ion batteries. The electrolyte additives minimize voltage fading and capacity fading observed in these batteries by reducing accumulation of passivation films on the electrode surface.
    Type: Application
    Filed: October 21, 2013
    Publication date: April 24, 2014
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: JIE XIAO, JIANMING ZHENG, JIGUANG ZHANG, EDUARD N. NASYBULIN, WU XU
  • Patent number: 8653258
    Abstract: The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.
    Type: Grant
    Filed: June 6, 2008
    Date of Patent: February 18, 2014
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Binghe Wang, Nanting Ni, Junfeng Wang, Chung-Dar Lu, Han-Ting Chou, Minyong Li, Shilong Zheng, Yunfeng Cheng, Hanjing Peng
  • Patent number: 8586796
    Abstract: The invention relates to new processes to prepare low odor dialkyl sulfides, the low odor dialkyl sulfides obtainable by these processes and to methods of using these low odor dialkyl sulfides. Moreover, the invention relates to a process to prepare dialkyl sulfide borane complexes of high purity, the dialkyl sulfide borane complexes obtainable by this process and to a process for enantioselective reductions employing these dialkyl sulfide borane complexes of high purity as reducing agent.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: November 19, 2013
    Assignee: BASF SE
    Inventors: Elizabeth Burkhardt, Kevin Neigh
  • Publication number: 20130302529
    Abstract: Embodiments of the invention include linking agents including borate, borazine, or boronate groups and coatings and devices that incorporate such linking agents, along with related methods. Other embodiments are also included herein.
    Type: Application
    Filed: May 2, 2013
    Publication date: November 14, 2013
    Inventor: SurModics, Inc.
  • Publication number: 20130277611
    Abstract: The present invention relates to compounds containing at least three ring systems, at least one of which is a 2,6-naphthylene group, and two unsaturated bridging groups between the ring systems, and to the use of the compounds for high-frequency components, in particular antennae, especially for the gigahertz region. The liquid-crystalline media comprising these compounds serve, for example, for the phase shifting of microwaves for tuneable ‘phased-array’ antennae.
    Type: Application
    Filed: December 14, 2011
    Publication date: October 24, 2013
    Applicant: MERCK PATENT GmbH
    Inventors: Christian Jasper, Elvira Montenegro, Detlef Pauluth, Volker Reiffenrath, Atsutaka Manabe
  • Patent number: 8546608
    Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: October 1, 2013
    Assignee: Cephalon, Inc.
    Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
  • Patent number: 8546617
    Abstract: A dioxaborinane compound, or salt thereof, where boron has two oxy substituents, each independently substituted with H, alkyl, alkenyl, aryl, —C(O)R3, —C(O)OR3, —C(O)NHR3, or the two oxy substituents, together with the oxygen atoms to which they are bonded, join to form a 5- or 6-membered ring; and R3 is H, alkyl, alkenyl, or aryl, where the alkyl and alkenyl are optionally interrupted with one or more oxygen or sulfur atoms; and where boron also has the substituent -L-X1-PG1; where L may be absent, or alkylenyl, alkenylenyl, or arylene, where the alkylenyl and alkenylenyl are optionally interrupted with one or more oxygen or sulfur atoms; X1 is absent, or is amino, oxo, thio, or phosphino; and PG1 is a polymerizable group. The dioxaborinane compound can be used as a wood preservative.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: October 1, 2013
    Assignee: Empire Technology Development LLC
    Inventors: William B. Carlson, Gregory D. Phelan
  • Patent number: 8530689
    Abstract: The invention concerns processes for the synthesis of a compound of the formula: wherein: R1 and R2 are each, independently, C1-C12 alkyl, CO2R3, OR4, R5(OR6), or C6-C18 aryl; R3-R6 are each, independently, C1-C12 alkyl or C6-C12 aryl; and n and m are each, independently, O or an integer from 1-5; said process comprising:—contacting a compound of the formula H0-R7-0H with BH3 and a compound of the formula in the presence of a nickel-containing catalyst to produce a first product, where R7 is a C2-C12 hydrocarbon group and X is a halogen, OMs or OTs;—contacting the first product in situ with a compound of the formula: in the presence of a nickel-containing catalyst to produce a compound of formula I, where Z is a halogen.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: September 10, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Virgil Percec, Brad Matthew Rosen, Daniela A. Wilson, Christopher J. Wilson
  • Patent number: 8513465
    Abstract: Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 20, 2013
    Assignee: SNU R&DB Foundation
    Inventors: Heonjoong Kang, Jungyeob Ham, Hong Ryul Ahn, Young Hee Park
  • Publication number: 20130184461
    Abstract: Mechanosynthesis trajectories are described which are approximately coaxial, and are shown to be useful in a wide range of mechanosynthesis reactions regardless of the nature of the tip or the feedstock being transferred.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 18, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Publication number: 20130178627
    Abstract: Methods and systems for building three-dimensional workpieces are described using a plurality of mechanosynthetic reactions. These methods may employ engineered reliability in reactions and process conditions and may use simulated or otherwise vetted reaction sequences, to allow workpieces requiring many reactions to be built with acceptable reliability. These many reactions may be the repetition of one or a small number of reactions, or many diverse reactions, or a combination thereof.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 11, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Publication number: 20130178626
    Abstract: Processes are described for manufacturing atomically-precise tips using one or more tips in one or more mechanosynthetic reactions to create one or more atomically-precise tips. The processes may employ a variety of feedstock, binding any of a wide range of atoms to a workpiece to build the one or more atomically-precise tips. The processes result in atomically-precise mechanosynthesis tips with a wide variety of possible tip structures using a wide range of feedstock binding elements. Characteristics of such tips that may be used when designing new embodiments are also described.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 11, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Patent number: 8481785
    Abstract: The invention pertains to new materials based on sterically inhibited donor arylboranes for the improvement of electron injection and electron transport in organic electronic components like organic light-emitting diodes (OLED's), organic field effect transistors (OFET's), and on organic photovoltaics based components, in particular, organic solar cells.
    Type: Grant
    Filed: August 23, 2006
    Date of Patent: July 9, 2013
    Assignee: Osram Opto Semiconductors GmbH
    Inventor: Andreas Kanitz
  • Patent number: 8455689
    Abstract: The present invention relates to a process for preparing substituted biphenylanilides of the formula I wherein R1 is a protected amino group which comprises reacting a compound of formula II in the presence of a base and of a palladium catalyst in a solvent, with an organoboron compound of formula (III)
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: June 4, 2013
    Assignee: Bayer CropScience AG
    Inventors: Michael Dockner, Heiko Rieck, Wahed Ahmed Moradi, Norbert Lui
  • Patent number: 8436211
    Abstract: The present invention relates to a process for the preparation of substituted biphenyls by reacting aryl halides with tetraarylborates in the presence of palladium catalysts.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: May 7, 2013
    Assignee: Bayer CropScience AG
    Inventors: Wahed Ahmed Moradi, Norbert Lui, Michael Dockner, Thomas Jagusch
  • Patent number: 8426347
    Abstract: The present invention describes a nanoparticle size composition comprising at least one overbase complex of a magnesium salt and an associated organic boron complex. The present compound is an improvement over previous processes due to less complicated processing requirements and the high concentration of both magnesium and boron that results.
    Type: Grant
    Filed: November 28, 2009
    Date of Patent: April 23, 2013
    Assignee: Envirochem Solutions LLC
    Inventors: Mark D. Hughes, Leslie J. Flinn, Daniel T. Smith, Nathaniel J. Smoter, Theo Eliades, Kenneth W. Koch, Sr.
  • Publication number: 20130066264
    Abstract: Disclosed are a sugar-responsive gel and a medicine administering device having a pKa more suitable for use in a body environment and capable of administering medicine more autonomously than before. A sugar-responsive gel and an insulin administering device having a pKa more suitable for use in a body environment and capable of administering insulin more autonomously than before, wherein under a body condition of pKa of 7.4 or less and temperature of 35° C.-40° C., when the glucose concentration increases, insulin can be released from a gel body in response thereto, and when the glucose concentration decreases, insulin release from the gel body can be suppressed.
    Type: Application
    Filed: May 24, 2011
    Publication date: March 14, 2013
    Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Akira Matsumoto, Takehiko Ishii, Kazunori Kataoka, Yuji Miyahara
  • Publication number: 20130066115
    Abstract: Methods for forming boronic acids, and intermediates thereof, are disclosed. The method may include mixing a 1-chloro-2-substituted-3-fluorobenzene starting material with an alkyllithium in a first reactor to form a reaction mixture. The 1-chloro-2-substituted-3-fluorobenzene starting material may react with the alkyllithium to form a lithiated intermediate. The reaction mixture may be continuously transferred to a second reactor and a borate may be continuously introduced to form a boronate. The boronic acids may be formed by treating the boronate with aqueous potassium hydroxide followed by acidification. Such methods may provide continuous formation of the boronic acids and may reduce an amount of a reactive intermediate present during processing as well as cycle times. Systems for forming the boronic acids are also disclosed.
    Type: Application
    Filed: September 14, 2012
    Publication date: March 14, 2013
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Mark V. M. Emonds, Catherine A. Menning, D. Wayne Blaylock
  • Patent number: 8394539
    Abstract: Lithium salts with fluorinated chelated orthoborate anions are prepared and used as electrolytes or electrolyte additives in lithium-ion batteries. The lithium salts have two chelate rings formed by the coordination of two bidentate ligands to a single boron atom. In addition, each chelate ring has two oxygen atoms bonded to one boron atom, methylene groups bonded to the two oxygen atoms, and one or more fluorinated carbon atoms bonded to and forming a cyclic bridge between the methylene groups.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: March 12, 2013
    Assignee: GM Global Technology Operations LLC
    Inventors: Olt E. Geiculescu, Ion C. Halalay, Darryl D. Desmarteau, Stephen E. Creager
  • Publication number: 20130059996
    Abstract: The synthesis, functionalization and characterization of borepin-based extended pi-electron molecules is disclosed. Bulky substituents shielded the vacant boron p-orbitals thus allowing synthetic manipulation and purification under ambient lab conditions. The presently disclosed borepin-containing compounds displayed reversible cathodic electrochemistry and can be viewed as n-type analogues to bent acene hydrocarbons.
    Type: Application
    Filed: April 8, 2011
    Publication date: March 7, 2013
    Inventors: John Dayton Tovar, Anthony Caruso, JR.
  • Publication number: 20120316364
    Abstract: The present invention provides a process for preparing triorgano borates with low alcohol content.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 13, 2012
    Applicant: BASF SE
    Inventors: Ronald J. Orosz, David F. Rouda, Karl Matos
  • Publication number: 20120309982
    Abstract: The present invention relates to electrolyte formulations comprising at least one compound of formula (I) Ma+[B(Rf)(CN)x(F)y]a— (I) in which Ma+ is an inorganic or organic cation, Rf denotes straight-chain or branched perfluoroalkyl groups having 1 to 4 C atoms, C6F5, C6H5, partially fluorinated phenyl or phenyl which is monosubstituted or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, a is 1 or 2, x is 1, 2 or 3, y is 0, 1 or 2 and x+y is 3 and their use in an electrochemical and/or optoelectronic device such as a photovoltaic cell, a capacitor, a light emitting device, an electrochromic or photo-electrochromic device, an electrochemical sensor and/or biosensor, preferably their use in a dye or quantum dot sensitized solar cell.
    Type: Application
    Filed: January 12, 2011
    Publication date: December 6, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Hiromi Shinohara, Kentaro Kawata, Hiroki Yoshizaki, Peer Kirsch, Nikolai (Mykola) Ignatyev, Michael Schulte, Jan Sprenger, Maik Finze, Walter Frank
  • Publication number: 20120309981
    Abstract: The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.
    Type: Application
    Filed: January 12, 2011
    Publication date: December 6, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Jan Sprenger, Maik Finze, Walter Frank
  • Patent number: 8318983
    Abstract: A protected organoboronic acid includes a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. A method of performing a chemical reaction includes contacting a protected organoboronic acid with a reagent, the protected organoboronic acid including a boron having an sp3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic group bonded to the boron through a boron-carbon bond. The organic group is chemically transformed, and the boron is not chemically transformed.
    Type: Grant
    Filed: July 25, 2011
    Date of Patent: November 27, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, Eric P. Gillis
  • Patent number: 8318699
    Abstract: The present invention is directed to compounds that are allosteric inhibitors of tumor necrosis factor receptor I, compositions comprising such compounds, and methods of using such compounds and compositions thereof in the treatment of TNF-? mediated conditions.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: November 27, 2012
    Assignees: The Trustees Of The University Of Pennsylvania, Cephalon, Inc.
    Inventors: Mark I Greene, Ramachandran Murali, Xin Cheng, Raphael Ottenbrite, Yingxin Xiao
  • Patent number: 8304579
    Abstract: The present invention relates to novel boronic acid aryl derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic acid aryl derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: November 6, 2012
    Assignee: Johns Hopkins University
    Inventor: Saeed R. Khan
  • Patent number: 8299290
    Abstract: The present invention relates to functionalizing agents that are particularly useful for functionalizing living rubbery polymers to make the polymer more compatible with fillers, such as carbon black and silica. These functionalizing agents are comprised of a boron containing compound having a structural formula selected from the group consisting of: wherein R is selected from the group consisting of hydrogen atoms, alkyl groups and aryl groups, wherein R1, R2, and R3 can be the same or different and are selected from the group consisting of alkyl groups, and aryl groups, and wherein R4 represents an alkylene group or a bridging aromatic group.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: October 30, 2012
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Robert Alan Woloszynek, Stephan Rodewald
  • Patent number: 8293724
    Abstract: Fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of oleamide (an endogenous sleep-inducing lipid) and anandamide (an endogenous ligand for cannabinoid receptors). Disclosed herein are potent inhibitors of FAAH and methods for their use for treating a variety of disorder, including hypertension and cardiac hypertrophy.
    Type: Grant
    Filed: April 6, 2010
    Date of Patent: October 23, 2012
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: George Kunos, Alexandros Makriyannis