Abstract: The present invention generally relates to systems and methods for changing tissue impedance in a region of a biologically generated field. In certain embodiments, the invention provides methods for changing tissue impedance in a region of a biologically generated field that involve applying focused energy to a region of charged particles in a region of tissue that includes a biologically based field, whereby the energy provided to the region of charged particles results in an impedance change to the region of tissue.

Abstract: Methods and devices are disclosed for the non-invasive treatment of neurodegenerative diseases through delivery of energy to target nervous tissue, particularly the vagus nerve. The devices include a magnetic stimulator having coils with toroidal windings, which are in contact with an electrically conducting medium that is adapted to conform to the contour of a target body surface of a patient. The coils induce an electric current and/or an electric field within the patient, thereby stimulating nerve fibers within the patient. The stimulation brings about reduction of neuroinflammation in patients suffering from conditions comprising Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis, postoperative cognitive dysfunction and postoperative delirium.

Abstract: Provided herein is a multichannel Transcranial Magnetic Stimulation (mTMS) coil device with two or more overlapping coil windings within a casing. The mTMS coil device is capable of adjusting parameters of the stimulation of magnetic and induced electric fields through the selective control of the multiple coil windings within the mTMS coil device. Additionally, provided are methods of operation including navigated TMS for adjusting parameters such as location, direction and/or orientation of magnetic and induced electric fields from mTMS coil devices.

Abstract: Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

Abstract: Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for a number of disorders. Described are methods and devices to treat disorders that involves no medication. Methods and devices described herein use alternating magnetic fields to gently “tune” the brain and affect mood, focus, and cognition of subjects.

Abstract: This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma.

Abstract: The present invention introduces a novel apparatus (5) for providing magnetic stimuli to the human brain, the apparatus (5) comprising a casing (4) and at least one coil winding (1) adapted to carry electrical current and enclosed within the casing (4) as well as cooling means (2) situated in thermal connection with the coil (1) and comprising a body made of electrically conductive and non-magnetic material so that the mutual inductance between the coil (1) and the cooling means (2) is essentially zero.

Abstract: A device is for extracorporeal magnetic innervation. The device allows a non-invasive, non-operative treatment using magnetic fields. In particular, the device is suitable for nerve stimulation by means of the magnetic fields which are generated, thereby resulting in the contraction of a muscle.

Abstract: Non-invasive and/or natural orifice procedures, apparatus and methods for modulating the enteric nervous system using one or more energy modalities. A system may include a probe for insertion into a natural orifice (e.g., nasogastrically, orogastrically, nasojejunally) with or without a tube to therapeutically apply energy to modulate one or more portions of the enteric nervous system. The methods described herein may provide energy to stimulate the enteric nervous system to treat disorders such as irritable bowel syndrome, constipation, depression, anxiety and/or to enhance gastric motility, intestinal motility or other neurological responses.

Abstract: The present invention relates to the control by magnetic fields (MF) of the activity of the mitochondrial enzyme adenosine triphosphate synthase (ATPS). Elimination of alternating and static MFs allows ATPS activity amplification (ATPSA), while a variety of MF frequency-intensity combinations interfere to various degrees with ATPS function (ATPSI). Control of ATPS, which is the endpoint of the mitochondrial oxidative phosphorylation system, allows alteration of intracellular adenosine triphosphate (ATP) levels, a molecule critical to the function of living organisms. Changes in ATP levels may trigger various events in cells, and prolonged ATPSI can lead to cell death. Specific combinations of MF frequencies and intensities maximize ATPSI for cancer cell killing and other health related applications.

Abstract: The invention is directed to a novel method for reducing discomfort caused by transcutaneous stimulation. The novel method includes providing transcutaneous stimulation, reducing the transcutaneous stimulation at a first location, and substantially maintaining the transcutaneous stimulation at a second location. The transcutaneous stimulation may be created by electric and/or magnetic fields. The first location may be relatively proximate to the cutaneous surface and may comprise tissue, nerves and muscle. Also, the second location may be relatively deeper than the first location and include, for example, brain tissue that requires the transcutaneous stimulation for treatment purposes. The invention further may include locating a conductor on a treatment area and/or a transcutaneous stimulation device relative to the first location. In addition, the method may further include adjusting how much the transcutaneous stimulation is reduced at the first location.

Abstract: Methods and devices for providing therapeutic electromagnetic field treatment to a subject having a cognitive or neurological condition or injury. Treatment devices can include headwear incorporating electromagnetic treatment delivery devices providing electromagnetic treatment to a user's head area. Such devices include protective headwear such as helmets with electromagnetic delivery devices. Additionally, embodiments of the invention provide for wearable and adjustable electromagnetic treatment devices that can be used to provide electromagnetic treatment to multiple areas of the user's head. Embodiments of the invention provide for sequential electromagnetic treatment with a single or a plurality of treatment applicators which target a single or multiple cerebral regions as determined by imaging, non-imaging and physiological monitoring before, during and after electromagnetic treatment.

Abstract: Devices, systems and methods for treating bronchial constriction related to asthma, anaphylaxis or chronic obstructive pulmonary disease include non-invasive nerve stimulators. The treatment comprises transmitting impulses of energy non-invasively to selected nerve fibers that are responsible for smooth muscle dilation. The transmitted energy impulses, comprising magnetic and/or electrical, mechanical and/or acoustic, and optical and/or thermal energy, stimulate the selected nerve fibers.

Abstract: One aspect of the present disclosure relates a system that can employ micromagnetic stimulation to activate or suppress one or more areas of the central nervous system. A portion of the central nervous system can be exposed. A probe can be configured to be located in proximity to the exposed portion of the nervous system. A microcoil (of a size less than or equal to 10 millimeters) can be coupled to the probe and configured to activate or suppress the portion of the central nervous system via electromagnetic induction.

Abstract: A method of determining an optimal coil shape for use in magnetic stimulation includes identifying a stimulation location and a constraint at the stimulation location. A first electromagnetic effect at the stimulation location is determined. The first electromagnetic effect is induced by a first electrical quantity assigned to a first current element at a first current element location with a first orientation. A second electromagnetic effect at the stimulation location is also determined. The second electromagnetic effect is induced by a second electrical quantity assigned to a second current element at the first current element location with a second orientation. Based on the first electromagnetic effect and the second electromagnetic effect, an optimal orientation of a current element at the first current element location is determined. The optimal orientation is such that the constraint is satisfied. Repeating the process at a plurality of locations yields the optimal coil shape.

Abstract: Disclosed are devices, methods, and systems for helping to prevent (or preventing) or treat brain and/or body disorders. Embodiments of the invention have utility for enhancing cognitive function during aging. The invention utilizes electromagnetic stimulation (EMS) that can provide a range of EMS parameters and modalities. The EMS may be utilized in conjunction with physiologic sensors that can provide feedback for possible EMS modifications.

Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Abstract: A coil for transcranial magnetic stimulation which is location-specific for unilateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements and return elements are distributed on one side of a central axis of the coil.

Abstract: A transcranial magnetic stimulation coil which is location-specific for frontal lobe regions, occipital lobe regions, parietal lobe regions, right temporal regions and left temporal regions is designed with multiple spaced apart stimulating elements having current flow in a substantially circular direction, and multiple return elements having current flow in substantially the same circular direction.

Abstract: There is provided a medical device comprising a low to intensity electromagnetic field source to increase the respiratory control values (RCI) of mitochondria. The medical device may be implantable, such as a cardiac rhythm management device, a stent, or a vascular graft. The device may also be worn externally, such as a treatment device haying matrix of magnetic coils that is worn on the head for the treatment of various neurological conditions.

Abstract: The invention involves enhancing brain function by stimulating the brain using magnetic fields. Applications of the new methods include improving the condition of individuals with cognitive disorders, such as depression, and studying the effects of neural stimulation using induced electric fields. These techniques can avoid deleterious effects of psychotropic pharmaceutical treatments, and provide a relatively safe, comfortable, inexpensive means of direct cranial stimulation.

Abstract: A coil suitable for tissue stimulation and especially for transcranial magnetic stimulation (TMS) may be used in conjunction with a pulse generator to induce electric field in the brain with less attenuation in depth compared to existing TMS coils. In an example, a coil winding is formed in a solenoid configuration around the head. Various related features, methods, and embodiments are described.

Abstract: Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.

Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract: A transcranial magnetic stimulation induction coil device (“TMS coil device”) is manufactured to contain coil windings of a predetermined size and shape and fixedly positioned at a predetermined location within and orientation in relation to a casing of the TMS coil device. In one embodiment, the coil windings are encased in a casting at a predetermined location within and orientation in relation to the casting, and the casting is fixedly positioned at a predetermined location within and orientation in relation to the casing. The size and shape of the coil windings and the casing within, and the location and orientation of the coil windings in relation to each other and the casing of, the TMS coil device are known with a high level of precision, such that navigated brain stimulation can be performed with the TMS coil device with a high degree of accuracy.

Abstract: A system and methods for transcranial magnetic stimulation, the system including a helmet, a positioning portion, a stimulator and a cooling system, are disclosed. The helmet includes a coil for deep brain magnetic stimulation. The coil has a base portion, and return portions, which may include a protruding return portion and a contacting return portion. The coil is designed to minimize unintended stimulation of portions of the brain, while reducing accumulation of surface charges. The coil is stimulated at several locations and/or at different times so as to focus the electrical field on a specific deep neuronal structure.

Abstract: Apparatus and methods which enable the stimulation of neurons oriented in all directions within a biological structure using applied magnetic fields.

Abstract: An energy emitting apparatus for providing a medical therapy includes one or more energy generators, a logic controller electrically connected to the one or more energy generators, and one or more sensors for detecting electric conduction in a target nerve that are connected to the logic controller. The one or more energy generators produce energy focused on the target nerve upon receiving a signal from the logic controller, and the energy is varied by the logic controller according to an input provided by the one or more sensors. In one embodiment, the energy emitting apparatus is an apparatus for magnetic induction therapy that includes one or more conductive coils disposed in an ergonomic housing that produce a magnetic field focused on the target nerve upon receiving an electric current from the logic controller based on an input provided by the one or more sensors.

Abstract: An exercise device having therapeutic properties is provided. The device includes a first element and a second element relatively movable with respect to the first element. A resistance-generating mechanism links the first and second elements to impede the relative motion of the first and second elements so that the user must exercise or expend energy to overcome the resistance of the first and second elements. A first magnet is disposed in at least one of the first or second elements in a location where a user's body part contacts the first or second element during use. The magnetic field of the first magnet is directed into the user's body part for therapeutic effect, preferably from the north pole of the magnet. A second magnet or set of magnets may be employed for therapeutic effect and/or to increase the resistance of the device by using magnetic interaction (either attraction or repulsion) to further impede the relative motion of the first and second elements.

Abstract: This invention relates to an apparatus that regulates thermodynamic energy-flow within a human body for producing beneficial effects such as, for example, improvement in strength, improvement in stamina, pain relief, etc. According to one embodiment, the invention provides a wearable apparatus that may include biomolecular components for building-up of a thermomagnetic energy within the human body. According to another embodiment, the invention provides a wearable apparatus that may include biomolecular components for dilution of a thermomagnetic energy within the human body. According to yet another embodiment, the invention provides a wearable apparatus that may include biomolecular components having orthomolecular and/or non-orthomolecular organic materials which are capable of thermomagnetic levororotary action and/or thermomagnetic dextrorotatory action.

Abstract: Disclosed is a method of reducing bleed time in a subject by activation of the cholinergic anti-inflammatory pathway in said subject. The cholinergic anti-inflammatory pathway can be activated by direct or indirect stimulation of the vagus nerve. The cholinergic anti-inflammatory pathway can also be activated by administering an effective amount of cholinergic agonist or acetylcholinesterase inhibitor to the subject.

Abstract: Methods of stimulating a target deep brain region using multiple Transcranial Magnetic Stimulation (TMS) electromagnets positioned over a predetermined cortical regions each having a first-order connection to a target deep brain region and applying TMS so that the applied TMS induces spatial summation and thereby modulation of the target deep brain region.

Abstract: Apparatuses, systems and methods of treating a vertebrate organism via application of signals in a manner that enhances biological function. The signals applied can be produced by an electronic circuit, and can comprise magnetic fields emitted via one or more coil emitter devices.

Abstract: Described herein are shaped coil TMS electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the TMS electromagnet. For example, the vertex region may be horizontal or vertical. In some variations the vertex region is formed by re-arranging the conductive windings forming the two coils so that they are no longer arranged in the same columnar structure that they are in the other portions of the bent magnetic coil loops. These TMS electromagnets may be well suited for use in deep-brain Transcranial Magnetic Stimulation.

Abstract: A system and method for inducing physiological effects of ischemic conditioning and physiological effects of shear stress in a subject's body that mimic the effect of exercise on the subject. The disclosure includes a first device configured to cause ischemia, a second device configured to mechanically generate arterial shear stress, and a third device configured to monitor one or more of markers of ischemia or hemodynamic parameters and further including a microcontroller and actuators to cause the ischemia for a preset duration and then stop the ischemia for a preset duration, and to repeat the ischemia and reflow periods according to a preset program, simultaneously cause the second device to mechanically generate arterial shear stress according to a preset program of mechanical pulse amplitude, duration, and frequency; and to concurrently monitor hemodynamic parameters or markers of ischemia.

Abstract: The invention relates to an apparatus for stimulating a healing process comprising a coil arrangement which is coupled to a functional power generator in order to generate an electromagnetic field in an affected body region, a control unit for influencing a voltage curve generated by the functional power generator in accordance with signals transmitted to an input interface of the control unit, a sensor array for sensing a characteristic of the affected body region, transmission device which is coupled to the sensor array in order to transmit a signal characteristic of the detected characteristic of the affected body zone to the control unit.

Abstract: In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.

Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract: An electrical system having an underlying structure resembling the double helix most commonly associated with DNA is used to produce useful electromagnetic fields for health applications and/or medical applications.

Abstract: A magnetic field therapy apparatus includes a first wire coil, a second wire coil and an electrically conductive member connecting the coils in series. The coils are wound in the same direction. In a preferred embodiment the coils are wrapped around a single bobbin, with the first coil forming a bottom layer and the second coil wrapped around the first coil and forming a top layer. AC power coupled to the coils energizes the coils and generates a magnetic field within the bobbin interior region. When current enters one coil it induces current in the other coil, thereby creating a scalar effect, producing energy in the form of a helix. The waves are identical, but out of phase temporally, that is, physically identical, but 180 degrees out of phase in terms of time. In an alternate embodiment, the coils may be on separate bobbins. A trigger may be applied to the part of a body undergoing therapy.

Abstract: Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache. The disclosed methods may also be used to treat other disorders that may be co-morbid with migraine headaches, such as anxiety disorders. In preferred embodiments of the disclosed methods, one or both of the patient's vagus nerves are stimulated non-invasively. In other embodiments, parts of the sympathetic nervous system and/or the adrenal glands are stimulated.

Abstract: A deep brain magnetic stimulator is disclosed that is placed within a vessel of the body to provide targeted location specific application of a magnetic field within the brain. The deep brain magnetic stimulator has a stimulation coil affixed to an expandable device core where the device core has a lumen to allow the passage of blood. A source of electrical energy is provided as well as related control circuitry to govern the activation of the stimulation coil and also govern such parameters as magnetic field strength, duration, waveform, and the like.

Abstract: Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically embodiments of present disclosure relate to devices or constructs and methods to prepare various devices or constructs useful in directing cellular repair and controlling tissue regeneration to prevent or minimize postsurgical or post traumatic adhesions, excessive scars and/or fibrotic reactions of injured tissues.

Abstract: A device to promote the production of neurotrophic factor without transplantation of cells or injection into the affected area is provided. The device contains a high frequency electromagnetic wave generating means generating a high frequency electromagnetic wave. The magnetic stimulation by the high frequency alternating electromagnetic field allows the intracellular concentration of calcium ions to increase to induce exocytosis of the neurotrophic factor group and to increase mRNA of the neurotrophic factor group in the cells so that the synthesis and extracellular release of the neurotrophic factor group are promoted. The device is suitable for use in preventing or treating various diseases such as brain diseases.

Abstract: The present invention relates to the in vivo stimulation of cellular material. In particular, the present invention relates to a method for stimulating cells and tissue in vivo comprising the step of applying to said cells and tissue an electrobiomimetic stimulus, wherein the growth characteristics of said cells and tissue are enhanced as compared to cells and tissue not receiving said stimulus.

Abstract: The present invention relates to a system and method of applying a therapeutic electrical field to a bone region of a human being in order to promote healing and growth that that bone region. The present invention also provides a system that produces a combined magnetic field (CMF) that is precisely located and controlled across the entire treatment area requiring bone growth stimulation by utilizing bone dimensional input parameters to automatically calculate and drive the appropriate output therapy single through a single coil.

Abstract: Systems and methods are disclosed for electromagnetically stimulating a brain and pairing temporally associated sensory stimulation to treat a neurologic or psychiatric disorder or to enhance cognitive, motor, social, or psychological skills. In addition, a non-invasive brain stimulation device is configured to stimulate a patient's brain by emitting an electromagnetic field based on certain stimulation parameters that may be dynamically adjusted based on measurements regarding brain activity. An additional exemplary embodiment of the disclosed subject matter is a method of neuroplastic augmentation using brain stimulation designed to augment, hasten, enhance, optimize, or improve a secondary neurologic or psychiatric treatment for a brain illness.

Abstract: An electrical system having an underlying structure resembling the double helix most commonly associated with DNA is used to produce useful electromagnetic fields for health applications and/or medical applications.

Abstract: A portable multi-sensor device (1) comprises a substantially sheet-like and at least partially flexible unit support element (2), a garment (W) designed to be worn by a user and to be removably associated with the unit element (2), a plurality of sensors (S), adapted to detect biological and/or vital parameters on the body of a user and transduce them into electric signals, at least one of which is incorporated in the unit support element (2), transceiver means (6) for remote transmission of the electric signals to a remote monitoring center (C), processing and control means (6?) for processing and controlling the associated electric signals, therapeutic treatment means (21) associated with the unit support element (2) and designed to contact one part of the wearer's body.

Abstract: An interventional device (12) is configured to be positioned in a body and includes an electrically operable unit (E1, E2) configured to carry out an interaction with the body upon a receipt of electric power. The device further includes a sensor (2) configured for wirelessly receiving electromagnetic energy from a remote source. The sensor is configured as a resonant circuit (2a, 2b) which converts the received electromagnetic energy into the electric power. The electrically operable device may include a diagnostic and/or therapeutic module.