Combined With Other Radiant Or Wave Energy Source (e.g., Electromagnetic, Thermal, Microwave Etc.) Patents (Class 600/2)
  • Patent number: 10357661
    Abstract: Process and device for directly medicinally treating interior tissue during or after intubation of a patient by passing medicinal radiant energy transversely through the intubation device to irradiate the internal patient tissue for promoting healing or for an antimicrobial effect. The invention is useful in conjunction with endoscopies and catherizations, such as urinary catherization, gastric and pulmonary endoscopies, and the like procedures. The process and device can also provide liquid flow and/or vision.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 23, 2019
    Assignee: PERCUVISION, LLC
    Inventors: Ake A. Hellstrom, Errol O. Singh
  • Patent number: 10342993
    Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: July 9, 2019
    Assignee: PROCEPT BioRobotics Corporation
    Inventors: Rodney Perkins, Nikolai Aljuri
  • Patent number: 10335609
    Abstract: A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a catheter body with a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween. The system further includes an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration. The system also includes a plurality of tubes disposed about at least a portion of the expansion device. Each of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: July 2, 2019
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: John Greskovich, Jr., Shengqiang Gao
  • Patent number: 10035025
    Abstract: A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (SRS). The range shifting device can be incorporated into an existing SRS localization system during SRS treatment. The range shifting device is configured to be placed close to the head of a patient during SRS treatment. The range shifting device is comprised of range shifting material. The range shifting device can be a range shifting helmet. The range shifting helmet can include a hollow frame including a plurality of apertures in which inserts made of range shifting material can be inserted.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: July 31, 2018
    Assignee: University of Iowa Research Foundation
    Inventors: Dongxu Wang, Daniel Hyer, Blake Dirksen
  • Patent number: 10016620
    Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: July 10, 2018
    Assignee: PROCEPT BIOROBOTICS INCORPORATION
    Inventors: Nikolai Aljuri, Rodney Perkins, Surag Mantri
  • Patent number: 10007961
    Abstract: A treatment schedule for radiopharmaceuticals is developed by collecting a volumetric history of tissue uptake in identified volumes of interest using emitted-radiation scans and relating this data to a treatment-radiopharmaceutical to develop a quantitatively accurate radiation treatment schedule of delivery amounts and delivery times of the treatment-radiopharmaceutical. This data may also be used to model biological effective dose and to prepare augmenting external radiation beam treatment schedules.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: June 26, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Joseph J. Grudzinski, Robert Jeraj, Wolfgang A. Tome, Jamey P. Weichert
  • Patent number: 9694075
    Abstract: Methods and systems for treatment of hypoxic tumors are provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering an oxygenating agent to the tumor tissue via the delivery device and radiating the tumor tissue with radiation. Methods and systems of treatment of tumors are also provided, including the steps of positioning a delivery device in a bodily cavity adjacent to tumor tissue, delivering a photosensitizing agent to the tumor tissue via the delivery device, and radiating the tumor tissue with light.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: July 4, 2017
    Assignee: Sanovas, Inc.
    Inventors: Lawrence J. Gerrans, Erhan H. Gunday
  • Patent number: 9550071
    Abstract: A method for generating light intensity inside a tumor to aid in the treatment of diseases such as cancer is disclosed. The light is generated inside the body to perform a modified photodynamic therapy treatment (PDT) that allows treatment of body regions that are inaccessible by normal PDT procedures. In addition, the use of two spatially and temporally coincident treatment modalities, i.e. radiation and PDT, have the potential for significant biological synergy in the tumor.
    Type: Grant
    Filed: November 27, 2012
    Date of Patent: January 24, 2017
    Assignee: THE UNIVERSITY OF HOUSTON SYSTEM
    Inventors: Abdelhak Bensaoula, John Christopher Boney, A. Sam Beddar, Tina Marie Briere, Sunil Krishnan, Andrew K. Lee
  • Patent number: 9375275
    Abstract: An electromagnetic surgical ablation probe having a tunable helical antenna element is disclosed. The probe includes a coaxial feedline having an inner conductor coaxially disposed within a dielectric, and an outer conductor coaxially disposed around the dielectric. The inner conductor and dielectric extend distally beyond a distal end of the outer conductor. A helical antenna element is operably coupled to a distal end of the inner conductor. During use, the antenna may be tuned by changing at least one dimension of the helical antenna element. Embodiments are presented wherein a dimensions of the helical antenna element is changed by state change of a shape memory alloy, by a change in temperature, by activation of a piston by fluidic pressure, by linear motion of a conical tip, and by a manual screw-type adjustment.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: June 28, 2016
    Assignee: COVIDIEN LP
    Inventors: Anthony C. Lee, Kenlyn S. Bonn
  • Patent number: 9320915
    Abstract: Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section suitable for retaining within a body cavity such as the uterus, both during radiation treatment and during recovery time between radiation treatments. This distal portion can be intended for single-patient use and be disposed of after completion of a radiation treatment session having multiple radiation dose treatment times. One or both of real time in vivo detection and monitoring and hypertherapy features can be included. One or more of the system tandem or ovoid colpostats feature bendability to tailor the system to the specific body and patient being treated. The method includes having a tandem distal section inserted into a body cavity such as a uterus and remaining within the body cavity in between treatment times.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: April 26, 2016
    Inventor: Mark A. D'Andrea
  • Patent number: 9283408
    Abstract: A proton beam delivery system including a proton beam nozzle to emit a proton beam to a targeted region of a patient, a gantry wheel to support the proton beam nozzle, the gantry wheel being configured to rotate the proton beam nozzle about a rotation axis of the gantry wheel such that the proton beam nozzle emits the proton beam to an isocenter of the gantry wheel corresponding to the targeted region, a beamline deflector configured to be rotated by the gantry wheel to transport the proton beam along a curvilinear path from the rotation axis to the proton beam nozzle using a predetermined power setting of the beamline deflector, and a rigid support structure to support the beamline deflector when the gantry wheel is rotated such that the beam nozzle directs the proton beam to the isocenter from a plurality of radial directions using the same predetermined power setting.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: March 15, 2016
    Assignee: ProNova Solutions, LLC
    Inventors: Jonathan Huber, Alan Henley
  • Patent number: 9149652
    Abstract: Among other things, a method for transporting radiation to a body region is described, wherein, in a first step, a canal is formed up to the body region to be irradiated and wherein, in a second step, an applicator (10) which is fitted to the diameter of the canal is introduced into the canal in order to guide a probe tip. Advantageously, applicator (10) is formed for use with a radiation therapy device for producing a defined radiation dose for irradiating a body region, whereby applicator (10) has a base body (11) with a foot region (12) for the uptake of at least one component of a radiation therapy device (30), a cylindrical guide region (13) connecting thereto for the uptake of a probe tip of a radiation therapy device, whereby a transition region (14) is formed between the foot region (12) and the guide region (13), as well as a head region (15), which is formed at the distal end (21) of base body (11). The method can be utilized especially for the treatment of tumors in the vertebral column.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: October 6, 2015
    Assignee: CARL ZEISS MEDITEC AG
    Inventors: Frederik Wenz, Dietrich Wolf, Norbert Reng, Holger Fuchs
  • Patent number: 9095359
    Abstract: A microwave ablation system includes an energy source adapted to generate microwave energy and a power splitting device having an input adapted to connect to the energy source and a plurality of outputs. The plurality of outputs are configured to be coupled to a corresponding plurality of energy delivery devices. The power splitting device is configured to selectively divide energy provided from the energy source between the plurality of energy devices.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: August 4, 2015
    Assignee: Covidien LP
    Inventors: Robert J. Behnke, II, Mani N. Prakash, Jeffrey L. Jensen, Francesca Rossetto, Joseph D. Brannan
  • Patent number: 9040945
    Abstract: Apparatus for performing electron radiation therapy on a breast cancer patient preferably includes an intraoperative electron radiation therapy machine, an intraoperative electron radiation therapy collimator tube connected to the intraoperative electron radiation therapy machine, and a plurality of filters made of a material having substantially the same density as human breast tissue for placement between the machine and the patient to change the energy of a monoenergetic beam after the beam has left the machine, allowing a filter to be chosen to reduce the energy traveling through the tube to a desired amount of energy to treat the patient.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: May 26, 2015
    Inventor: Jonathan S. Hayman
  • Publication number: 20150141734
    Abstract: The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium (4), and uses a device (1) comprising first and second ultrasound means (11,12) and first and second displacement members (13,14) for moving the ultrasound means (11,12). The parameters include signals s1,s2 to the ultrasound means (11,12), and the positions x1,x2 of the ultrasound means (11,12). The parameters are optimized for having a minimum amplitude a1,a2 of the signals s1,s2 and having an acoustic effect inside the medium (4).
    Type: Application
    Filed: March 8, 2013
    Publication date: May 21, 2015
    Inventors: Jean-Yves Chapelon, Cyril Lafon, Jean-Louis Mestas
  • Patent number: 9005099
    Abstract: Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
    Type: Grant
    Filed: February 14, 2012
    Date of Patent: April 14, 2015
    Assignee: Seros Medical, LLC
    Inventors: Mark S. Blumenkranz, Edward E. Manche, Satish V. Herekar, Donald J. Eaton
  • Patent number: 8974363
    Abstract: New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: March 10, 2015
    Assignee: Provectus Pharmatech, Inc.
    Inventors: H. Craig Dees, Timothy C. Scott, John Smolik, Eric A. Wachter, Walter G. Fisher
  • Publication number: 20150065782
    Abstract: A method is provided including identifying a target portion of a patient corresponding to a portion of interest of the patient to be scanned with a nuclear medicine scanning technique. The method also includes applying an uptake increasing technique to at least one of the target portion or an application portion of the patient other than the target portion. The uptake increasing technique is configured to increase uptake of a radiopharmaceutical to the target portion of the patient relative to portions of the patient other than the target portion. Also, the method includes administering the radiopharmaceutical to the patient temporally proximate to the applying an uptake increasing technique.
    Type: Application
    Filed: August 30, 2013
    Publication date: March 5, 2015
    Applicant: General Electric Company
    Inventors: Leonid Tsukerman, Yaron Hefetz
  • Patent number: 8952346
    Abstract: The subject matter described herein provides methods for developing an IMRT treatment plan for a radiotherapy system. In one aspect, the method can include providing initial treatment parameters. These parameters can include a number of isotopic beams, a transmission angle for each beam, a prescribed dose for a target, and dose volume histogram constraints. The method can further include determining an initial fluence map including one or more beamlets. The initial fluence map can specify a fluence value for each beamlet. The method can further include determining a delivery sequence for the fluence values in the initial fluence map. The delivery sequence can include one or more apertures formed by the leaves of a collimator. These apertures can have a specified size constrained to substantially less than a maximum size associated with the collimator, when the isotopic beam is near a critical structure. Related apparatus and systems are also described.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 10, 2015
    Assignee: ViewRay Incorporated
    Inventors: James F. Dempsey, Iwan Kawrykow
  • Publication number: 20140378738
    Abstract: An irradiation system for simultaneous application of radiation therapy and hyperthermia is provided. The irradiation system has a radiation source and a magnetic resonance tomography apparatus comprising a controller, a plurality of local coils for arrangement on the body of a patient, and a plurality of transmission devices. The transmission devices are configured to supply the local coils with radiofrequency signals independently of one another. In this case, the controller is configured to actuate the transmission devices in such a way that a predetermined region in the body of the patient is heated to a predetermined temperature by means of the radiofrequency signals emitted by the local coils. The radiation source is configured to irradiate a target in the predetermined region.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 25, 2014
    Inventor: BELA VAJKO
  • Patent number: 8915833
    Abstract: A microbeam intraoperative, 10-50 kilovoltage radiation therapy system with multiple simultaneous microfocus X-ray sources and method for image guided, microsecond duration, 100 to 1,000 Gy microbeam radiation therapies with dose rate ranging from 1,000 to 20,000 Gy per second and RBE closer to high LET with minimal toxicity to normal tissue is provided. Dismountable coronal, sagital and transverse half-circle gantry sections are assembled on to a surgical table for mounting the microfocus X-ray sources for intraoperative radiosurgery. A stereotactic breast core biopsy system is adapted for combined breast biopsy, positron emission tomography and computerized tomography with phase-contrast imaging. Cosmetic whole breast preserving electronic brachytherapy is combined with stereotactic core biopsy. The low dose valley regions of the intersecting microbeams at the tumor site are filled with scattered and characteristic radiation from high Z-element that is bound or implanted into the tumor.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: December 23, 2014
    Inventor: Velayudhan Sahadevan
  • Publication number: 20140343421
    Abstract: Provided are medical apparatuses for simultaneously performing radiotherapy and hyperthermia therapy and methods of treating an affected area. The medical apparatus includes a table where a subject is placed; a driving unit configured to move the table; a treatment device configured to treat an affected area of the subject; and an ultrasonic transducer configured to increase treatment efficiency of the affected area.
    Type: Application
    Filed: May 14, 2014
    Publication date: November 20, 2014
    Applicants: SAMSUNG LIFE PUBLIC WELFARE FOUNDATION, SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sang-hyun KIM, Young-sun KIM, Hyo-keun LIM, Won-chul BANG
  • Publication number: 20140330123
    Abstract: A sonic window includes a body sized and configured to close an opening formed through the cranium, wherein at least a part of the body is made of a sonically transparent material through which ultrasonic waves can pass.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: University of South Florida (A Florida Non-Profit Corporation)
    Inventors: Jotham Charles Manwaring, Kim Herbert Manwaring
  • Publication number: 20140286932
    Abstract: Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein. Decreased levels or altered distribution of giant obscurins in the cells compared to a control non-invasive standard or to a sample taken at a different point in time is indicative of increased potential of at least one of the invasiveness, metastasis, or recurrence of the epithelial cell cancer. The kit comprises a detection reagent suitable for detecting the presence and distribution of giant obscurins or an amount of the gene product(s) encoding giant obscurins in cells of a tissue sample and instructions for using the detection reagent.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 25, 2014
    Applicants: JOHNS HOPKINS UNIVERSITY, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Aikaterini Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos, Marey Shriver, Nicole Perry
  • Publication number: 20140275712
    Abstract: Radiation therapy devices, systems and methods are in general sheet-like form, are characterized by flexibility, and include at least one spacer that can be a balloon or bubble that assists in placement of radio therapeutic members at desired treatment locations along or around a limb, within an existing body cavity, or at a site that was formed under a patient's skin for treatment purposes. Sarcoma treatment is particularly conducive to treatment by these devices, systems and methods. One or more detectors, such as microdiodes, are accommodated when desired on the device, and a hyperthermia tube or the like is also includable that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventor: Mark A. D'Andrea
  • Publication number: 20140257013
    Abstract: Radiation therapy or brachytherapy devices, systems and methods are in general catheter form and include at least one balloon that assists in placement of radio therapeutic members at desired treatment locations within an existing body cavity or at a site that was formed under a patient's skin for treatment purposes. One or more detectors, such as microdiodes, are present on the device, and a hyperthermia tube or the like is also included that delivers hyperthermia treatment for the target treatment site or sites. Data collected by the detector allows the medical professional to monitor radiation treatment and, when desired, interaction between hyperthermia treatment and radiation delivery by the radiation treatment member.
    Type: Application
    Filed: March 6, 2013
    Publication date: September 11, 2014
    Inventor: Mark A. D'Andrea
  • Publication number: 20140228616
    Abstract: The system and methods of the invention partially shields the radiation dose to the skin and/or other anatomical organs by using magnetically responsive material that blocks radiation, which may be fine grains of iron or other ferrous powder for example. The powder is typically injected into an IB applicator, along with inflating saline solution in case of MSB, when a skin spacing problem is encountered, or there is a risk of high doses being delivered to the critical organs surrounding a lumpectomy cavity, for example. A slight magnetic field of predetermined configuration will be applied externally to arrange the shielding material internally under the segment of surface of the IB applicator where the skin spacing is typically less then 7 mm, thereby protecting the skin from radiation damage. Monte Carlo studies to develop parameterizations for treatment planning with the IB applicator utilizing the suggested shielding material is also provided.
    Type: Application
    Filed: April 16, 2014
    Publication date: August 14, 2014
    Applicant: HAMPTON UNIVERSITY
    Inventors: Cynthia E. KEPPEL, Vahagn R. NAZARYAN
  • Publication number: 20140163303
    Abstract: A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.
    Type: Application
    Filed: January 27, 2014
    Publication date: June 12, 2014
    Applicants: DUKE UNIVERSITY, IMMUNOLIGHT, LLC.
    Inventors: Frederic Avery BOURKE, JR., Tuan VO-DINH
  • Patent number: 8742348
    Abstract: A muon monitoring system for particle radiation therapy includes: a shield for a selective passing, by eliminating particles and radiation produced due to the high energy particles and radiation pulses, of the delay positrons emitted due to decay of muons stopped at a position corresponding to the Bragg peak position; a positron detector for detecting positrons from a designated direction and detecting the delay positrons passed through the shield opening by each of positron detecting plates for providing information of positron produced positions and time of delay simultaneous signals; and a control/analysis apparatus generating a delay signal at a timing delayed by a predetermined time period from a completion of irradiation of the high energy particle radiation pulses, and performing a process to generate ?SR signals segmented for each positron generating position by analyzing detected results obtained by operating the positron detector for a predetermined number of times.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: June 3, 2014
    Assignee: Inter-University Research Institute Corp. High Energy Accelerator Research Organization
    Inventor: Kanetada Nagamine
  • Publication number: 20140120167
    Abstract: Methods of treating diseases through the intracellular enhancement and synergy of chemo- and radiation-therapies by employing cancer cell-specific on-demand mechanical intracellular impact. The methods, quadrapeutics, combines four clinically validated modalities: encapsulated drugs, colloidal gold nanoparticles (GNPs), near-infrared short laser pulses, and X-rays.
    Type: Application
    Filed: October 30, 2013
    Publication date: May 1, 2014
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Dmitri Lapotko, Katsiaryna Hleb, Michael E. Kupferman, Daniel Scudder Wagner, Vladimir Torchilin, Xiangwei Wu
  • Patent number: 8696538
    Abstract: Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: April 15, 2014
    Inventor: Karl Otto
  • Publication number: 20140094643
    Abstract: An example particle therapy system includes the following: a gantry that is rotatable relative to a patient position; a particle accelerator mounted to the gantry, where the particle accelerator is for outputting a particle beam essentially directly to the patient position; and a control system to receive a prescription and to generate machine instructions for configuring one or more operational characteristics of the particle therapy system. At least one of the operational characteristics relates to a rotational angle of the gantry relative to the patient position.
    Type: Application
    Filed: September 27, 2013
    Publication date: April 3, 2014
    Applicant: Mevion Medical Systems, Inc.
    Inventors: Kenneth P. Gall, Stanley Rosenthal, Thomas C. Sobczynski, Adam C. Molzahn, Charles D. O'Neal, III, James Cooley
  • Patent number: 8680498
    Abstract: A method for utilizing an implant in a human breast includes forming a breast cavity within the breast at a lumpectomy site, the breast cavity having surrounding tissue; forming a substantially radio-opaque implant constructed of biocompatible and biodegradable material configured to allow for in-growth of fibrous tissue into and replacing the biocompatible and biodegradable material, the biocompatible and biodegradable material being elastically compressible; sizing the substantially radio-opaque implant to occupy the breast cavity; and implanting within the breast cavity the substantially radio-opaque implant to support the tissue surrounding the breast cavity, the step of implanting including compressing the biocompatible and biodegradable material.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: March 25, 2014
    Assignee: SenoRx, Inc.
    Inventors: John Corbitt, Lori Anthony
  • Publication number: 20140057844
    Abstract: The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders. In some aspects the compounds inhibit translation elongation at the ribosome. In some aspects the compounds are used alone or in combination with known therapies.
    Type: Application
    Filed: December 2, 2011
    Publication date: February 27, 2014
    Inventors: Tin Tin Su, Gan Zhang
  • Patent number: 8652022
    Abstract: A method of treating a region of diseased tissue using a probe is disclosed. A probe cannula is introduced into the tissue of the patient until a distal end of the cannula is located at or proximate to the treatment region. A plurality of electrodes are then deployed from the distal end of the cannula into the treatment region. Energy (e.g., radiofrequency energy) is then delivered through the plurality of electrodes to the tissue. The cannula is then secured to an immobile object external to the patient. The treatment region is irradiated with a therapeutically effective dose of an ionizing radiation while the plurality of electrodes remain at least partially advanced within the treatment region and while the cannula remains secured to the immobile object.
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: February 18, 2014
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Robert Rioux
  • Patent number: 8641592
    Abstract: A method and device for image guided dynamic radiation treatment of prostate cancer and other pelvic lesions including: 1) a unique fan geometry of radiation sources; 2) a special collimation method and apparatus to sculpt the radiation borders; 3) an integrated three-dimensional imager and a special tissue interface imaging system to locate and track critical boundaries in real-time; 4) a dynamic patient support system, which is shared by the said imager and the irradiation system; and 5) motorized custom shielding filters to further protect neighboring normal tissues such as the kidneys and femoral heads. The fan geometry utilizes a plural number of radiation sources arranged specifically for irradiating tumors in the human pelvis while not harming critical structures, and the collimation sculpts the radiation borders using motorized shields for different sensitive structures.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: February 4, 2014
    Inventor: Xinsheng Yu
  • Publication number: 20140018605
    Abstract: Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 16, 2014
    Applicant: Pulmonx Corporation
    Inventors: Peter P. Soltesz, Nikolai Aljuri, Ajit Nair
  • Patent number: 8629415
    Abstract: A radiation therapy apparatus includes a gantry having a central aperture that defines a cavity, in which a patient is positionable. The apparatus also includes a positioning device, with which the patient is positionable in the central aperture of the gantry, and a radiation head for generating therapeutic radiation. The apparatus includes an extension mechanism for the radiation head. The extension mechanism may be operated, such that in a first operating mode, the radiation head is disposable inside the gantry, such that the gantry has, on a side facing the positioning device, a front surface that constitutes a front limit of the radiation therapy apparatus toward the positioning device. In the first operating mode, the radiation head is behind the front surface viewed from the positioning device. In a second operating mode, the radiation head, viewed from the positioning device, may be moved out in front of the front surface.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: January 14, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventor: Franz Fadler
  • Publication number: 20130323232
    Abstract: Disclosed herein are methods of stratifying a patient population into an IGF-1R inhibitor responder or resistant population comprising assaying a sample of cells derived from a patient to determine if a cell from the patient sample is sensitive to treatment with an IGF-1R inhibitor and selecting a patient for treatment with an IGF-1R inhibitor if the cells from the patient are determined to be sensitive. The determination is based upon either the expression levels of wild type LKB1 in the patient sample wherein a low level of expression of the protein or the gene encoding the biomarker protein is predictive of a favorable outcome to an IGF-1R targeted therapy or detecting the presence of a loss of function mutant LKB1 in the sample, wherein presence of the mutant is predictive of a favorable outcome.
    Type: Application
    Filed: November 22, 2010
    Publication date: December 5, 2013
    Inventors: Sriram Sathyanarayanan, Christopher Winter, Youyuan Xu
  • Publication number: 20130317276
    Abstract: Intracavitary brachytherapy tandem and ovoid oncology treatment systems and methods are provided. One such system and method employs a multi-part tandem having a detachable distal section retained within a body cavity during and between radiation treatments. This can be for single-patient use and disposed of after completion of a multiple-dose radiation treatment session. Real time in vivo detection and monitoring and hytpertherapy features can be included. Tandem or ovoid colpostats can feature bendability to tailor the system to the specific body and patient being treated. Other systems and methods incorporate balloon devices that assist in spacing radiation doses away from chosen body sites. Balloon devices also can be provided for adjusting and maintaining separation spacing between two ovoid colpostats.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 28, 2013
    Inventor: Mark A. D'Andrea
  • Patent number: 8567410
    Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: October 29, 2013
    Assignee: Ethris GmbH
    Inventors: Carsten Rudolph, Joseph Rosenecker
  • Publication number: 20130261371
    Abstract: Imageable disruptable capsules containing a sensitizing agent or a protecting agent are used to enhance radiation therapy. Said capsules may be imaged by a non-invasive imaging modality, allowing for the determination of the precise timing to disrupt the capsule and release the sensitizing agent or protecting agent using an external energy source. This controlled and timed release of the sensitizing agent or protecting agent provides for enhanced radiation therapy by optimizing the delivery of the sensitizing agent or protecting agent to the target tissues. Systems comprising non-invasive imaging modalities, external energy sources and radiation energy sources are also taught for use with these imageable disruptable capsules.
    Type: Application
    Filed: May 3, 2011
    Publication date: October 3, 2013
    Applicant: UNIVERSITY HEALTH NETWORK
    Inventors: David A. Jaffray, Christine Allen, Devika Chithrani, Jinzi Zheng, Justin Grant
  • Patent number: 8541764
    Abstract: A method of partial breast radiation therapy includes placing within a breast cavity a substantially radio-opaque implant constructed of biocompatible material, said substantially radio-opaque implant supporting the tissue surrounding the breast cavity; and directing a radiation beam to said substantially radio-opaque implant serving as a target for delivery of radiation therapy to margins around the breast cavity, such that the radiation beam does not materially irradiate the whole of the breast.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: September 24, 2013
    Assignee: Senorx, Inc.
    Inventors: John Corbitt, Lori Anthony
  • Patent number: 8536547
    Abstract: Systems, methods, and related computer program products for image-guided radiation treatment (IGRT) are described. For one preferred embodiment, an IGRT apparatus is provided comprising a ring gantry having a central opening sufficiently large to accommodate a body of a patient positioned along a longitudinal axis and extending therethrough, and a gantry tilting mechanism configured to tilt the ring gantry to a plurality of different tilt angles relative to the longitudinal axis. A radiation treatment head is coupled to the ring gantry and is rotatable around said central opening in at least a 180 degree arc. The radiation treatment head is mechanically coupled to the ring gantry such that a distance by which the radiation treatment head extends inwardly toward the central opening relative to the ring gantry is dynamically controllable.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: September 17, 2013
    Assignee: Accuray Incorporated
    Inventors: Calvin R. Maurer, Jr., Eric P. Lindquist
  • Patent number: 8500693
    Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: August 6, 2013
    Assignee: Becton Dickinson France
    Inventor: Lionel Maritan
  • Publication number: 20130197295
    Abstract: Methods are provided for the treatment of diseases and disorders using systematically-introduced nanoparticles to create a focused localized hyperthermia in a target area to enhance the effect of additional treatment therapies such as ionizing radiation. Advantages include an enhancement of the therapeutic effect of other therapies by increasing perfusion or reducing hypoxia in the treatment area, further, the methods herein may also result in the disruption of the vasculature, which provide further impetus for such treatments, singly and in combination with conventional therapies such as chemotherapy and radiation therapy.
    Type: Application
    Filed: January 16, 2013
    Publication date: August 1, 2013
    Applicants: The Board of Regents of the University of Texas System, Nanospectra Biosciences, Inc.
    Inventors: Sunil Krishnan, Parmeswaran Diagaradjane, Jon Alexander Schwartz, James Chunjay Wang
  • Publication number: 20130131432
    Abstract: Disclosed is a method to use tuned resonant frequency ultrasonic energy for treatment of cancer that selectively destroys neoplastic cells while leaving surrounding healthy tissue minimally affected.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 23, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Eric Kline
  • Publication number: 20130131433
    Abstract: The invention provides for a therapeutic apparatus comprising a tissue heating system (302, 480, 482). The therapeutic apparatus further comprises a magnetic resonance imaging system (300) for acquiring magnetic resonance thermometry data (366) from nuclei of a subject (318) located within an imaging volume (330). The therapeutic apparatus further comprises a radiation therapy system (304, 592) for irradiating an irradiation volume (316, 516) of the subject, wherein the irradiation volume is within the imaging volume. The therapeutic apparatus further comprises a controller (354) for controlling the therapeutic apparatus. The controller is adapted for acquiring (100, 210) magnetic resonance thermometry data repeatedly using the magnetic resonance imaging system. The controller is adapted for heating (102, 208) at least the irradiation volume using the tissue heating system. The heating is controlled using the magnetic resonance thermometry data.
    Type: Application
    Filed: January 5, 2011
    Publication date: May 23, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Ulrich Katscher, Oliver Lips, Christian Findeklee, Christoph Leussler, Kay Nehrke, Daniel Wirtz, Johannes Adrianus Overweg
  • Patent number: 8423125
    Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: April 16, 2013
    Assignee: Spectrum Dynamics LLC
    Inventors: Benny Rousso, Shlomo Ben-Haim, Michael Nagler, Omer Ziv, Ran Ravhon, Dalia Dickman, Yoel Zilberstein, Eli Dichterman, Simona Ben-Haim, Shankar Vallabhajosula, Daniel Berman, Zohar Bronshtine, Ziv Popper, Nir Weissberg, Nathaniel Roth, Haim Melman
  • Publication number: 20130066190
    Abstract: A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy.
    Type: Application
    Filed: October 31, 2012
    Publication date: March 14, 2013
    Inventor: Gholam A. Peyman