Combined With Other Radiant Or Wave Energy Source (e.g., Electromagnetic, Thermal, Microwave Etc.) Patents (Class 600/2)
  • Patent number: 7618362
    Abstract: An apparatus comprises an elongated delivery member and a scaffold. The elongated delivery member has a distal end, a fixed portion and an actuator portion. The actuator portion is disposed proximate to the distal end. The actuator portion and the fixed portion are movable with respect to each other. The scaffold is mounted to the elongated delivery member proximate to the distal end. The scaffold has a first end coupled to the fixed portion. The scaffold has a second end coupled to the actuator portion. The scaffold is changeable between a stowed configuration and a deployed configuration by movement of at least the actuator portion and the fixed portion relative to each other.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: November 17, 2009
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Paul DiCarlo, Robert F. Rioux
  • Patent number: 7582050
    Abstract: A combination applicator is able to deliver heat and radiation, either simultaneously or sequentially, for the treatment of cancer or other disease. The combination applicator is flexible and able to conform to contoured anatomy of the patient. The combination applicator comprises a flexible, dielectric containing compartment having a tissue-engaging surface and an opposite, non-tissue-engaging surface. A heating surface comprising one or more RF or microwave antennas or ultrasound transducers is supported adjacent to the non-tissue-engaging surface. In addition, a plurality of conduits are also supported on the dielectric containing compartment, the conduits being adapted to communicate with at least one brachytherapy source. Additional conduits may be located on the tissue contacting surface of the dielectric containing compartment to accommodate moving or stationary temperature monitoring sensors.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: September 1, 2009
    Assignees: The Regents of the University of California, Bionix Development Corporation
    Inventors: Jaime L. Schlorff, Paul R. Stauffer
  • Publication number: 20090202650
    Abstract: A method of treating cancer. The method includes introducing an effective amount of an oxidative catalyzing agent including titanium oxide, zinc oxide, zirconium oxide, tungsten oxide or tin oxide into a biological entity, and irradiating the biological entity with a ray. The oxidative catalyzing agent produces hydroxyl or hydrogen peroxide radicals after irradiation with the ray thereon.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 13, 2009
    Inventors: Yeu-Kuang Hwu, Tsung-Yeh Yang, Chi-Jen Liu, Chang-Hai Wang
  • Publication number: 20090198093
    Abstract: A system and method of treating cancerous tissues using a combination of embolization and ablation therapies is described. An imaging device is used to determine the tissue volume to be treated, and the steps of embolization and ablation are performed while the patient remains on a treatment table. The embolization treatment may be combined with chemotherapy directly administered to the tumor. The position of the volume to be treated is visualized by the imaging device to monitor the progress of the treatment and to guide ablation treatment so as to mitigate collateral tissue damage. The imaging device may be a C-arm X-ray device, a MRI device, an acoustic device or other device capable of producing CT-like images.
    Type: Application
    Filed: February 6, 2008
    Publication date: August 6, 2009
    Inventors: Oliver Meissner, Thomas Redel
  • Patent number: 7524275
    Abstract: An interstitial brachytherapy apparatus and methods for treating proliferative tissue disorders with radiation and a surface delivered treatment agent. The brachytherapy device includes an insertion member having proximal and distal portions and at least one lumen extending therethrough. An expandable surface member is mated to the distal portion of the insertion member and includes a treatment agent releasably mated thereon. When the brachytherapy device is positioned within a tissue cavity and the expandable surface member is expanded, at least a portion of the treatment agent is delivered to tissue surrounding the tissue cavity.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: April 28, 2009
    Assignee: Cytyc Corporation
    Inventors: Timothy J. Patrick, James B. Stubbs
  • Publication number: 20090069624
    Abstract: A method of treating a region of diseased tissue using a probe is disclosed. A probe cannula is introduced into the tissue of the patient until a distal end of the cannula is located at or proximate to the treatment region. A plurality of electrodes are then deployed from the distal end of the cannula into the treatment region. Energy (e.g., radiofrequency energy) is then delivered through the plurality of electrodes to the tissue. The cannula is then secured to an immobile object external to the patient. The treatment region is irradiated with a therapeutically effective dose of an ionizing radiation while the plurality of electrodes remain at least partially advanced within the treatment region and while the cannula remains secured to the immobile object.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 12, 2009
    Inventor: Robert Rioux
  • Publication number: 20090054720
    Abstract: The present invention relates to a method for the treatment of cancer in a patient in need thereof. The method comprises administering to a patient in need thereof a first amount of a histone deacetylase inhibitor in a first treatment procedure, and a second amount or dose of radiation in a second treatment procedure. The first and second treatments together comprise a therapeutically effective amount. The combination of the HDAC inhibitor and radiation therapy is therapeutically synergistic.
    Type: Application
    Filed: October 8, 2008
    Publication date: February 26, 2009
    Inventors: George Sgouros, Victoria M. Richon, Paul A. Marks, Richard A. Rifkind
  • Patent number: 7481758
    Abstract: Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.
    Type: Grant
    Filed: April 1, 2002
    Date of Patent: January 27, 2009
    Assignee: Sirius Medicine, LLC
    Inventors: Michael Weil, Kevin N. Morris
  • Publication number: 20080288068
    Abstract: Methods for optimal breast reconstruction are disclosed. The methods include steps for performing a mastectomy that preserves a breast skin envelope. A prosthesis may be inserted into the breast and may be inflated to preserve the shape of the breast skin envelope. The prosthesis may include, a base, a balloon coupled to the base, where the balloon may be inflated to preserve the shape of the breast skin envelope. The prosthesis may also include tube coupled to port for filling the balloon to a predetermined volume. A needle-lock system, coupled to the port may be used to inject, for example, fluids into the balloon. If a patient requires post-mastectomy radiation, breast reconstruction may be delayed and the prosthesis may remain in the breast cavity during the treatment. The treatment may be external beam radiation. Alternatively, the treatment may include brachytherapy technique for treating the internal breast cavity.
    Type: Application
    Filed: August 9, 2006
    Publication date: November 20, 2008
    Inventor: Steven J. Kronowitz
  • Publication number: 20080287728
    Abstract: A marker system includes a structure having a first surface and a second surface, a first marker located on the first surface, and a second marker located on the second surface, wherein the first marker and the second marker are arranged so that they face approximately a same direction, and so that they can be simultaneously viewed by an optical device, and wherein a first distance between the first marker and the optical device is different from a second distance between the second marker and the optical device when the first and the second markers are simultaneously viewed by the optical device.
    Type: Application
    Filed: May 14, 2007
    Publication date: November 20, 2008
    Applicant: Varian Medical Systems Technologies, Inc.
    Inventors: Hassan Mostafavi, Andrew G. Jeung
  • Publication number: 20080234531
    Abstract: A system for treating target cells with both positive and negative ions comprises a bi-polar beam delivery system configured to create and deliver both positive ion beams and negative ion beams. The bi-polar beam delivery system comprises a bi-polar accelerator configured to accelerate positive and negative ions in the same direction making such a bi-polar bema delivery system practical.
    Type: Application
    Filed: March 23, 2007
    Publication date: September 25, 2008
    Inventors: Larry Welch, Ray Winn
  • Patent number: 7425193
    Abstract: A tomographic imaging system comprising a source array emitting rays, a deformable mirror reflecting the rays emitted by the source array, and a detector array receiving the electromagnetic rays emitted by the source array and reflected by the deformable mirror. An object can be positioned between the deformable mirror and the detector array and the deformable mirror can be deformed to a plurality of configurations to form a tomographic image of the object. The system can also be used in radiation therapy.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: September 16, 2008
    Assignee: Michigan State University
    Inventors: Satish S. Udpa, Lalita Udpa
  • Publication number: 20080221382
    Abstract: An embodiment of the invention is related to a system for providing radiotherapy to a treatment region. The system includes a radiation source and a sound source. The radiation source is positioned to irradiate the treatment region. The sound source is positioned to provide ultrasound to the treatment region so that the treatment region is subject to coincidental treatment by irradiation and ultrasound.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 11, 2008
    Applicant: Sunnybrook Health Sciences Centre
    Inventors: Raffi Karshafian, Gregory Czarnota, Peter N. Burns
  • Publication number: 20080206148
    Abstract: A method and apparatus for immunoimaging and destruction of malignant tumors using immunoimaging agents comprising nanoclusters incorporating monoclonal antibodies that selectively bind to the cell membrane of tumor cells, and conjugated payloads comprising an encapsulated near-infrared (NIR) fluorescing crystal. The encapsulated fluorescing crystal compound provides excellent non-radiometric imaging of the tumor, and the non-antigenic metal coating encapsulating the fluorescing crystal particles provides a non-destructive necrotic killing of the tumor cells by low-level radiometric amplification and heating of the tumor cell membrane. Thus the very same nanoclusters used during imaging also serve to kill the tumor cells by necrosis, damaging the cell membrane by overheating as a result of secondary irradiation (not by harmful radiometric-induced apoptosis).
    Type: Application
    Filed: November 7, 2006
    Publication date: August 28, 2008
    Inventor: Anastasios Tousimis
  • Publication number: 20080108858
    Abstract: An apparatus for sterilizing a blood vessel in a patient's inner skin includes a generator for providing gaseous radioisotope and a chamber adapted to exposure of a portion of a patient's body to the gaseous radioisotopes. When a patient is contacted with gaseous radioisotopes, alpha and beta particles are emitted from the gaseous radioisotopes into inner skin of the patient. Ultraviolet rays, subsequently emitted from the skin, sterilize viruses or bacteria present in a blood vessel. A method of treating a patient with the apparatus is also provided.
    Type: Application
    Filed: June 21, 2007
    Publication date: May 8, 2008
    Inventor: Young-Woong Park
  • Publication number: 20080071131
    Abstract: A radiation therapy system for irradiating a target volume with a particle beam is provided. The radiation therapy system includes a radiation source that is operable to output an adjustable irradiation field that includes a particle beam that is scanned point by point over the target volume. A 3D imaging device may obtain a 3D radiation treatment data set in a radiation treatment phase. An adaptation unit adapts the irradiation field to a change in position and/or shape of the target volume in the radiation treatment phase. The adaptation unit compares the 3D radiation treatment data set with a 3D planning image data set furnished and obtains a transformation that describes the change in position and/or shape of the target volume. The adaptation unit transforms an irradiation field based on the transformation.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 20, 2008
    Inventor: Eike Rietzel
  • Patent number: 7311655
    Abstract: The invention relates to a method for producing a radioactive brachytherapy source material comprising indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new radioactive brachytherapy source material comprises indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new encapsulated radioactive brachytherapy source comprises the new radioactive brachytherapy source material.
    Type: Grant
    Filed: March 17, 2003
    Date of Patent: December 25, 2007
    Assignee: Nucletron B.V.
    Inventor: Dennis Robert Schaart
  • Patent number: 7197404
    Abstract: The present system and method for simulating particles and waves is useful for calculations involving nuclear and full spectrum radiation transport, quantum particle transport, plasma transport and charged particle transport. The invention provides a mechanism for creating accurate invariants for embedding in general three-dimensional problems and describes means by which a series of simple single collision interaction finite elements can be extended to formulate a complex multi-collision finite element.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: March 27, 2007
    Inventor: Richard Andrew Holland
  • Patent number: 7161164
    Abstract: A garment and method for reducing electromagnetic radiation produced by a transmitting device typically located inside a body. The garment may include material to prevent or lower electromagnetic radiation. A method for using such a garment to lower electromagnetic emissions is described.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: January 9, 2007
    Assignee: Given Imaging Ltd.
    Inventor: Arkady Glukhovsky
  • Patent number: 7022136
    Abstract: Improved method and apparatus for neutron capture therapy are provided that may beneficially be used to counteract restenosis wherein a stent comprises a stable nuclide having a large neutron capture cross-section that may be irradiated with thermal neutrons applied by an external source, after placement of the stent, thereby giving rise to therapeutic radiation in the proximity of the stent. Because the stent only contains stable nuclides, it can be handled without the precautions needed when handling radioactive matter. An improved stent and a method for manufacturing the stent also are provided.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: April 4, 2006
    Assignee: Abbott Laboratories Vascular Entities Limited
    Inventor: Hans Lundqvist
  • Patent number: 6986764
    Abstract: A method for photoselective vaporization of prostate tissue includes delivering laser radiation to the treatment area on the tissue, via an optical fiber for example, wherein the laser radiation has a wavelength and irradiance in the treatment area on the surface of the tissue sufficient because vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation. The laser radiation is generated using a neodymium doped solid-state laser, including optics producing a second or higher harmonic output with greater than 60 watts average output power. The delivered laser radiation has a wavelength for example in a range of about 200 nm to about 650 nm, and has an average irradiance in the treatment area greater than about 10 kilowatts/cm2, in a spot size of at least 0.05 mm2.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: January 17, 2006
    Assignee: LASERSCOPE
    Inventors: Scott A. Davenport, Steven C. Murray, Tony D. Coleman, Henry Garlich, Ken Arnold, Kester Nahen
  • Patent number: 6957108
    Abstract: A microwave hyperthermia apparatus that can be inserted into the body which includes a hollow central tube for the insertion of radioactive therapy sources. The use of a coaxial transmission line impedance transformation along the insertable portion of the coaxial cable enables a reduction in the characteristic impedance by increasing the outer diameter of the inner coaxial conductor so that the center conductor can be a metal tube. If the ratio of the outer coaxial conductor diameter vs. the inner coaxial conductor is decreased, the characteristic impedance of the transmission line is lowered. This enables the inner conductor diameter to increase sufficiently to make the central hollow opening large enough to receive standard radioactive sources therein. This provides for a good impedance match that improves microwave energy efficiency while at the same time permitting a large hollow center opening.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: October 18, 2005
    Assignee: BSD Medical Corporation
    Inventors: Paul F. Turner, Mark Hagmann, Thomas Youd
  • Patent number: 6942617
    Abstract: A tracking system for stone treatment by extracorporeal shock wave lithotripsy includes a data processing unit, a motion controller, a servo-moving platform, a stone image-processing module, a stone localization module, and a moving-mechanism control module. With the use of the stone-tracking system, the performance of an extracorporeal shock wave lithotriptor can be greatly improved, resulting in less side effect such as tissue damage.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: September 13, 2005
    Inventors: Shen-Min Liang, Ioannis Manousakas, Yong-Ren Pu, Fan-Ming Yu, Chien-Chen Chang, Chin-Hsing Chen
  • Patent number: 6876712
    Abstract: A flexible source wire is provided containing a radioactive source that is capable of maneuvering through a tortuous narrow passage to a treatment site within the body. This source wire includes a thin flexible housing tube, housing therein a flexible backbone wire, wherein both the tube and the wire are constructed from a material exhibiting little or no memory retention when bent. A radioactive core is provided in the proximal end (i.e., the treatment end) of the thin flexible housing tube and abuts the proximal end of the backbone wire. Both ends of the source wire are sealed and the proximal end of the source wire is rounded to allow ease of movement as it travels through the bends and turns in the body.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: April 5, 2005
    Assignee: Interventional Therapies, L.L.C.
    Inventor: Samuel F. Liprie
  • Patent number: 6866624
    Abstract: The present invention relates to a device for simultaneously treating a tumor or cancerous growth with both hyperthermia and X-ray radiation using brachytherapy. The device includes a needle-like introducer serving as a microwave antenna. Microwaves are emitted from the introducer to increase the temperature of cancerous body tissue. The introducer is an inner conductor of a coaxial cable. The introducer contains a hollow core which houses an X-ray emitter. The X-ray emitter is connected to a high voltage miniature cable which extends from the X-ray emitter to a high voltage power source. The X-ray emitter emits ionizing radiation to irradiate cancerous tissue. A cooling system is included to control the temperature of the introducer. Temperature sensors placed around the periphery of the tumor monitor the temperature of the treated tissue.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: March 15, 2005
    Assignee: Medtronic AVE,Inc.
    Inventors: Victor I. Chornenky, Vance Swanson, Russell G. Hodge, Peter G. Davis
  • Publication number: 20040122280
    Abstract: Optical probes that may withstand a variety of hostile environments and that may provide high optical throughput are described herein. According to one exemplary embodiment, an optical probe may include a tube, an optical element, a cap, and a spring. The tube may have a first end, a second end, and an inner surface. The optical element may be insertable into the tube through the first end and may have an outer surface. A portion of the tube inner surface and a portion of the optical element outer surface may be matably tapered to provide a substantially fluid tight seal between the tube and the optical element. The cap may be attachable to the first end. The spring may be compressible between the optical element and the cap.
    Type: Application
    Filed: December 19, 2002
    Publication date: June 24, 2004
    Inventor: Robert W. Forney
  • Patent number: 6752752
    Abstract: A multi-source x-ray/catheter delivers x-rays to a selected site within a body lumen. The x-ray sources are independently operable so that only the x-ray sources adjacent the target site generate x-rays during the procedure.
    Type: Grant
    Filed: February 14, 2003
    Date of Patent: June 22, 2004
    Assignee: SciMed Life Systems, Inc.
    Inventor: Kurt Alfred Edward Geitz
  • Patent number: 6728335
    Abstract: A controller is provided for selectively and independently control each of a plurality of therapeutic radiation sources arranged along an array. The controller is operable to selectively generate therapeutic radiation at selected time intervals and at selected intensities. The controller includes intensity control circuitry for controlling the intensity of the therapeutic radiation generated by each therapeutic radiation source. The controller also includes duration control circuitry for controlling the duration of the therapeutic radiation generated by each therapeutic radiation source. The controller may also include a mechanical introducer for inserting the array into a treatment region, and for withdrawing the array from the treatment region.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: April 27, 2004
    Assignee: Carl-Zeiss-Stiftung
    Inventors: Euan Thomson, Mark Dinsmore
  • Patent number: 6705984
    Abstract: This invention relates to a novel idea for irradiating a patient with a beam of Muon (&mgr;) particles, which in the proton (H+) rich environment of the blood and the cells catalyzes more fusions of the Hydrogen-Deuterium, Deuterium-Deuterium, and Deuterium-Tritium nuclei. Through local radiation of the related body part(s), the already existing fusion energy is accelerated within the particular body part(s), thus facilitating the treatment of diseases. Muon bombardment of the cells can be applied for the treatment of all kinds of conditions and injuries, including AIDS and other infectious diseases, all cancers, all varieties of internal and external injuries and internal disorders, weight loss, repairment and rejuvenation of all body organs, treatment of enzyme inhibition, all neurological disorders, including paralysis, all psychological disorders, all genetic disorders, all endocrine system disorders, and all musculoskeletal disorders.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: March 16, 2004
    Assignee: Maktab Tarighe Oveyssi Shah Maghsoudi
    Inventor: Nader Angha
  • Publication number: 20040006254
    Abstract: Contrast agents developed specifically for x-ray diagnostics provide dose-enhanced radiotherapy and radiosurgery. The presence of heavy elements, for example, gold or iron, from these contrast agents, even small quantities, leads to a major dose increase in target tissue when combined with in vivo calibration of the amount of contrast agent. The technique can also be used in combination with other techniques, such as focused x-rays, to achieve further enhancement of therapeutic ratio. The technique is enhanced by employing oil-based contrast agents, which will remain in the target much longer than conventional agents. Through optimization of the equipment it is possible to achieve very large ratios of dose in target to dose in healthy tissue.
    Type: Application
    Filed: April 1, 2002
    Publication date: January 8, 2004
    Inventors: Michael Weil, Kevin N. Morris
  • Patent number: 6665555
    Abstract: A system for delivery of high dosage of radiation to a targeted spinal area is provided. This is accomplished by a system which provides for precise immobilization and positioning of the treated spinal area during dose planning and treatment via stereotactic radiosurgery. Advantages of the system include convenience to the patient, enhanced efficacy, and reduced risk of radiotoxicity to non-target tissues.
    Type: Grant
    Filed: April 5, 2001
    Date of Patent: December 16, 2003
    Assignee: Georgetown University School of Medicine
    Inventors: Fraser C. Henderson, James Rodgers, Azam Niroomand-Rad, Kevin Cleary, Anatoly Dritschilo, Leon Der
  • Patent number: 6663554
    Abstract: The method and device of the present invention for ultrasound wound treatment includes a transducer to produce ultrasonic waves. The ultrasonic transducer has tip with the distal end (radiation surface). A liquid is directed to the radiation surface throug central orifice or separate tube wherein an directed atomized particle spray of the liquid is created upon contact of the liquid with the radiation surface. The spray directed to the wound from at least 0.1 inches transmits ultrasound waves trough particles and has an irrigation, mechanical cleansing, liquid energizing and bactericide effect.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: December 16, 2003
    Assignee: Advanced Medical Applications, Inc.
    Inventor: Eilaz Babaev
  • Patent number: 6616594
    Abstract: A cartridge is configured to be inserted into a medical instrument for treating patients with radioactive seeds. The cartridge includes a rotating internal barrel that is loaded with a plurality of seeds, where the internal barrel has a plurality of conduits for accepting the seeds. As the internal barrel rotates, a seed from one of the conduits is deposited into a shuttle, and then the shuttle is fully extended so as to provide the seed to the medical instrument. The shuttle is then retracted, and the barrel is rotated to the next conduit, so as to receive a seed from that next conduit. The cartridge includes a first shield and a second shield, each having slots where the slots of the first and second shields are aligned in a first verification or calibration mode, and where the slots are not aligned in a normal, seed depositing mode. The second shield also includes a plurality of numeric indicators that indicate a current number of seeds remaining in the cartridge.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: September 9, 2003
    Assignee: Integrated Implant Systems, L.L.C.
    Inventors: Diego Y. Fontayne, Daniel E. Ueda, Edward J. Kaplan, Steven S. Ravins, Ernest A. Elgin, III
  • Publication number: 20030163016
    Abstract: A displacement difference dosimetry method is provided for use with in-vivo scintillating fiber radiation detectors. A scintillating fiber includes an insertion end which is incrementally inserted into a human body using a catheter or hypodermic needle to provide a fixed (but not necessarily known) insertion path. A photomultiplier tube is coupled to the other end of the scintillating fiber and detects both scintillation light and any Cerenkov light for each position of the scintillating fiber insertion end along the fixed insertion path. The change in the amount of light detected by the photomultiplier tube divided by the corresponding amount of change in position of the scintillating fiber insertion end gives a measure of the dose rate at the scintillation fiber tip which is substantially free from the effects of Cerenkov light.
    Type: Application
    Filed: February 28, 2002
    Publication date: August 28, 2003
    Inventor: Louis R. Testardi
  • Publication number: 20030135084
    Abstract: The method and apparatus of the invention are directed to surgically non-invasively treating skeleto/muscular injuries or of diagnosing bone fractures, involving application of two components of ultrasonic energy, to an external surface of living tissue, wherein the two components are of different frequencies in the range between 10 kHz and 4 MHz, and wherein separate transducers, each uniquely supplied with an excitation signal at a different one of said two frequencies, are directionally disposed for acoustic propagation on the same directional axis.
    Type: Application
    Filed: January 28, 2003
    Publication date: July 17, 2003
    Inventor: Michael John Radley Young
  • Patent number: 6572823
    Abstract: An apparatus and method are provided for handling a solution. The apparatus comprises a housing and a vial assembly positioned within an enclosure of the housing. The vial assembly maintains at least one vial within the enclosure of the housing. A valve manifold extends within the enclosure of the housing for connection to the vial. A rotation mechanism, also extending within the enclosure of the housing, is operatively connected to the vial assembly for rotating the vial assembly.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: June 3, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: John J. Donahue, Joseph Haepers
  • Publication number: 20030083536
    Abstract: A methodology and system for lysing adipose tissue including directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue, thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes and computerized tracking of the multiplicity of target volumes notwithstanding movement of the body.
    Type: Application
    Filed: October 29, 2001
    Publication date: May 1, 2003
    Applicant: ULTRASHAPE INC.
    Inventors: Yoram Eshel, Ilia Vitsnudel
  • Patent number: 6554824
    Abstract: Methods are provided for treating prostate glands or other targeted soft tissue using a solid-state laser. The laser can be operated to generate a pulsed output beam having pulse durations of between 0.1 and 500 milliseconds. The output beam is delivered to the targeted tissue through an optical fiber, preferably terminating in a side-firing probe or diffusing tip. By operating the laser in a long-duration pulse mode, charring of the targeted tissue is initiated quickly, thereby increasing ablation rates and reducing overall procedure time.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: April 29, 2003
    Assignee: Laserscope
    Inventors: Scott Davenport, Steven C. Murray, Tony Coleman
  • Publication number: 20030068009
    Abstract: A general computer-implemented method and computer program for an independent MU or dose and fluence calculation of an intensity modulated photon field in intensity modulated radiation therapy (IMRT) is provided. The present invention provides for the verification MU or dose calculation in high dose regions or low dose regions. In general, the dose at an arbitrary spatial point is expressed as a summation of the contributions from all the beamlets in a treatment field, each modulated by a dynamic modulation factor. The verification of a low dose region is based on using the inverted field of the low dose region. The advantage of the present invention that it is an independent method and therefore generally applicable and useful irrespective of the type of leaf sequence algorithm and delivery machines. It provides an automated computer-implemented method or program that generalizes and simplifies dose verification in IMRT.
    Type: Application
    Filed: February 15, 2002
    Publication date: April 10, 2003
    Inventor: Lei Xing
  • Publication number: 20030045768
    Abstract: An ultrasonic probe for microscopic operations in accordance with the present invention consists mainly of an ultrasonic probe body, an elongated tubular member, and a bent handle member. The ultrasonic probe body has a transducer assembly attached to the distal end of a soft elongated tube that is extended from a connector to be coupled to an ultrasonic observation apparatus, and has a coupler mounted on the tube thereof. The transducer assembly and tube are passed through the elongated tubular member. The handle member is attached to the proximal end of the tubular member and includes a coupling mechanism for use in coupling the coupler to the handle member so that the coupler can be uncoupled freely.
    Type: Application
    Filed: December 7, 2000
    Publication date: March 6, 2003
    Inventors: Kenji Hirooka, Ichiro Ohdachi, Shinichi Tsutaki
  • Publication number: 20020173688
    Abstract: This invention discloses a method for treating tissue of a varicose vein, the method comprising applying ultrasonic vibrational energy targeting said varicose vein effective for stimulating and restoring tissue physiological functions of said vein. A catheter for treating tissue of a blood vessel comprises at least one ultrasound transducer element and at least a suction element configured and adapted for pulling the tissue toward the catheter radially, wherein the ultrasonic vibrational energy is provided by an ultrasound transducer element connected to an adjustable high frequency current source.
    Type: Application
    Filed: May 15, 2001
    Publication date: November 21, 2002
    Inventors: Peter Cheng Chen, Toshimasa Tokuno, Weng-Kwen Raymond Chia, Cary Hata
  • Patent number: 6466813
    Abstract: A method and apparatus are provided for MR based volumetric frameless 3-D interactive localization, virtual simulation, and dosimetric radiation therapy planning. Using an MR imaging device, a patient is scanned to generate a magnetic resonance image volume data set. Using the MR data set exclusively, parallel and divergent volume images of the patient is displayed for target tissue identification, localization, virtual simulation, and dosimetric radiation therapy planning. Preferably, the interactive localization, simulation, and dosimetric RTP is based exclusively on the 3-dimensional MR volume data set rendered in the form of at least one of a multi-planar reformatted image (MPR), an oblique multi-planar reformatted image (OMPR), a digitally reconstructed “radiograph” (DRR), and a digitally composited “radiograph” (DCR).
    Type: Grant
    Filed: July 22, 2000
    Date of Patent: October 15, 2002
    Assignee: Koninklijke Philips Electronics N.V.
    Inventors: Himanshu P. Shukla, Krishna K. Gadepalli
  • Patent number: 6391279
    Abstract: Novel radioactive seeds for brachytherapy and a reproducible method of manufacturing the seeds is described, wherein the seeds contain either Pd-103 or I-125 disposed within a cured resin matrix.
    Type: Grant
    Filed: November 13, 1998
    Date of Patent: May 21, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Prahlad R. Singh, Gerald P. Tercho, Jack N. Wentz, Keith R. Olewine
  • Patent number: 6387380
    Abstract: A method and apparatus applies radiant energy through the skin to an underlying subcutaneous layer or deeper soft tissue layers that includes loculations of fat with fibrous septae made of collagen tissue. This creates a desired contour effect without substantially modifying melanocytes and other epithelial cells in the epidermis. A membrane conforms a contacting exterior surface of the membrane to a skin layer. One or more thermal electrodes positioned in the membrane. A focussing element focuses thermal energy to the underlying collagen tissue. The focusing element and the electrolytic solution create a reverse thermal gradient from the skin to the collagen tissue. A thermal power source is coupled to the thermal electrodes.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: May 14, 2002
    Assignee: Thermage, Inc.
    Inventor: Edward W. Knowlton
  • Patent number: 6371903
    Abstract: An ultrasound therapy probe includes a therapy transducer movably mounted on a probe body, a partially deformable flexible casing disposed around the therapy transducer, and a guard ring that limits deformations of the flexible casing when the transducer moves with respect to the probe body. The therapy transducer can be moved between a therapy position and a retracted position, and the guard ring provides an end-of-travel stop against which the therapy transducer bears when in a therapy position. A first opening is provided for injecting liquid into the flexible casing, and a second opening is provided for withdrawing liquid from the flexible casing. The second opening is located on the guard ring so that bubbles are withdrawn from the flexible casing as soon as they form.
    Type: Grant
    Filed: June 22, 2000
    Date of Patent: April 16, 2002
    Assignee: Technomed Medical Systems, S.A.
    Inventors: Emmanuel Blanc, Christian Chaussy, Stefan Thüroff
  • Publication number: 20010051760
    Abstract: The invention relates to the use of photofrin as a radiosensitizer in the treatment of tumorous tissue, wherein after a predetermined time interval after application of the photofrin an irradiation of the tumorous tissue with ionizing radiation is effected.
    Type: Application
    Filed: April 27, 2001
    Publication date: December 13, 2001
    Inventors: Alfons Hofstetter, Eckhart Duhmke, Moshe Schaffer, Giulio Jori, Luigi Corti
  • Publication number: 20010039420
    Abstract: A device and method for treatment of a tissue specimen disposed in surrounding tissue has a tissue specimen isolating tool and a tissue specimen damager. The tissue specimen isolating tool isolates the tissue specimen from the surrounding tissue. The tissue specimen damager damages the tissue, with a possible end result being necrosis. The severing tool may have a cutting member that is extendable to an outwardly radially bowed position about device. The tissue specimen is isolated by rotating the cutting member about the tissue specimen. The cutting member may be functionally connected to a cutting member radio frequency generation source. The tissue specimen damager may damage the tissue specimen using ionizing radiation, cutting devices, thermal treatment devices, chemical treatment devices, or sealing an outer boundary of the tissue specimen.
    Type: Application
    Filed: June 18, 2001
    Publication date: November 8, 2001
    Applicant: SenoRx, Inc.
    Inventors: Fred H. Burbank, Paul Lubock
  • Patent number: 6251110
    Abstract: An energy based surgical device for the application of ultrasonic energy and Radio Frequency energy is disclosed. The surgical device has a housing and an acoustic assembly having an electrically conductive waveguide. The waveguide has a solid core and extends from the housing. A conductive element for conducting Radio Frequency energy to the waveguide is operably coupled to the waveguide. The distal end of the waveguide of the acoustic assembly has an end effector for the conduction of ultrasonic energy or Radio Frequency energy. A number of novel end effectors for the emulsification and cauterization of tissue are described.
    Type: Grant
    Filed: March 31, 1999
    Date of Patent: June 26, 2001
    Assignee: Ethicon Endo-Surgery, Inc.
    Inventor: Scott D. Wampler
  • Patent number: 6241670
    Abstract: A radio therapy system includes measuring an actual position of a micro-radiation source and radiation dose actually generated from the source, at predetermined times, during a therapeutic treatment. An accumulative radiation dose distribution is constantly generated in realtime, during the treatment, from the actually measured position and radiation dose and reference radiation dose distribution. An operator can monitor, in realtime, how the radiation dose distribution is developed, temporally, during the treatment. As a result, it is possible to irradiate a lesion with a requisite dose of radiation, minimize any un-required irradiation to a normal area around the lesion and achieve a therapeutic treatment with high precision.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: June 5, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventor: Kyojiro Nambu
  • Patent number: 6224848
    Abstract: Pharmaceuticals and Apparatus used in combination for diagnosis and tissue necrosis applicable to provide effective and selective therapy using the Mossbauer absorption phenomenon. Selected pharmaceutical compounds containing a radiation absorber isotope are administered to a tissue and excited by a radiation source which provides energy at the corresponding resonant Mossbauer absorption frequency of isotope containing pharmaceutical, where excitation effects nuclear transitions to cause highly selective energy absorption in the selected target tissue. For diagnostic purposes, de-excitation fluorescence of the isotope is monitored. For therapeutic purposes, the energy is converted to particle radiation by the isotope at the target tissue by internal conversion followed by an Auger electron cascade which results in radiolysis of DNA resulting in lethal double strand breaks in the DNA molecules of the target tissue.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 1, 2001
    Inventor: Randell L. Mills