Combined With Other Radiant Or Wave Energy Source (e.g., Electromagnetic, Thermal, Microwave Etc.) Patents (Class 600/2)
  • Publication number: 20130053618
    Abstract: The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.
    Type: Application
    Filed: September 10, 2012
    Publication date: February 28, 2013
    Applicant: Varian Medical Systems, Inc.
    Inventors: David F. O'Brien, Kathy A. McGovern, Bruce Bondurant, Robert Sutherland
  • Publication number: 20130018257
    Abstract: Device for administering heat to a cavity, tissue or vessel, characterised in that it takes the form of an insulated copper wire over the length of which is crimped a tube having a resistivity of more than 20 ??·cm, the copper wire (1) is in contact with the said tube at its distal extremity, the tube is enclosed over part of its length by at least one movable cylinder having an electrical resistance of less than 20 ??·cm, and the movable cylinder and the copper wire have means for connection to a current generator.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 17, 2013
    Inventor: Henri Mehier
  • Publication number: 20130012755
    Abstract: Various embodiments provide methods and systems for ultrasound treatment of tissue are provided. Accordingly, a method can include locating an implant in a site in a body, directing a medicant to at least one of the implant and the site, directing ultrasound energy to the site, and accelerating healing of the implant and/or native tissue at the site.
    Type: Application
    Filed: July 10, 2012
    Publication date: January 10, 2013
    Applicant: GUIDED THERAPY SYSTEMS, LLC
    Inventor: Michael H. Slayton
  • Patent number: 8348867
    Abstract: An apparatus and method for treating subcutaneous tissues using acoustic waves in the range of low acoustic pressure ultrasound waves is disclosed. The method includes injections of enhancing agents, wherein disruption of subcutaneous tissues and subcutaneous cavitational bioeffects are produced by ultrasound waves having a power that will not produce tissue cavitation in the absence of the enhancing agents. The apparatus and method of use is useful for treatment of subcutaneous abnormalities including cellulite, lipomas, and tumors.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: January 8, 2013
    Assignee: Cabochon Aesthetics, Inc.
    Inventors: Mark E. Deem, Hanson S. Gifford, III, Douglas Sutton
  • Publication number: 20120294801
    Abstract: Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT), particularly vascular-targeted PDT (VTP), of tumors and nonneoplastic vascular diseases such as age-related macular degeneration, and for diagnosis of tumors by different techniques.
    Type: Application
    Filed: April 16, 2012
    Publication date: November 22, 2012
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Avigdor Scherz, Yoram Salomon, Efrat Rubinstein, Alexander Brandis, Doron Eren, Karin Neimann
  • Publication number: 20120289761
    Abstract: Devices, systems, and methods are disclosed herein for treatment of a disease, disorder, or condition in a vertebrate subject. A device is provided that includes one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable, and a programmable controller configured to provide instructions to the one or more cooling elements in response to information regarding one or more physiological conditions of the vertebrate subject.
    Type: Application
    Filed: September 1, 2011
    Publication date: November 15, 2012
    Inventors: Edward S. Boyden, Roderick A. Hyde, Muriel Y. Ishikawa, Edward K. Y. Jung, Eric C. Leuthardt, Stephen L. Malaska, Elizabeth A. Sweeney, Lowell L. Wood, JR.
  • Publication number: 20120283503
    Abstract: The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions. The heating of diseased tissue either results in direct cell killing or makes the tumor more susceptible to radio- and/or chemotherapy. The NLSC of the present invention can be used for MR image-guided hyperthermia in oncology, in stem cell research for cell tracking and heating, and for elimination of mis-injected stem cells.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Lyubov Ostrovska
  • Publication number: 20120283502
    Abstract: Disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to treat depression, bipolar disorder, and other mood disorders. Also disclosed are methods and systems and methods for non-invasive neuromodulation using ultrasound to affect the mood or emotional state of a subject or user. The neuromodulation can produce acute or long-term effects. The latter occur through Long-Term Potentiation (LTP) or Long-Term Depression (LTD) via training. Included is control of direction of the energy emission, intensity, frequency, pulse duration, and phase/intensity relationships to targeting and accomplishing up regulation and/or down regulation.
    Type: Application
    Filed: March 21, 2012
    Publication date: November 8, 2012
    Inventors: David J. MISHELEVICH, Tomo SATO, William J. TYLER, Daniel Z. WETMORE
  • Patent number: 8304751
    Abstract: In a charged particle beam irradiation apparatus to be adapted to a particle beam cancer treatment system or the like, a desired depth dose distribution is highly precisely created. In the charged particle beam irradiation apparatus that irradiates a particle beam, which is radiated from a particle beam generation unit, to a subject to be irradiated via a ridge filter exhibiting a cyclic thickness distribution for causing the particle beam to exhibit a desired energy distribution, the ridge filter has plural ridges thereof arranged to be perpendicular to entering directions of the particle beam.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: November 6, 2012
    Assignee: Mitsubishi Electric Corporation
    Inventors: Taizo Honda, Hisashi Harada, Yuehu Pu
  • Publication number: 20120277517
    Abstract: An embodiment in accordance with the present invention provides a thermo-chemoembolization formulation and method for enhanced interventional image-guided therapy for cancer. The T-C formulation includes magnetic iron oxide nano-particles (MIONs) that heat when exposed to an alternating magnetic field (AMF), a liquid tumorphilic drug carrier that enhances tumor retention of the T-C formulation, and a chemotherapeutic or radiotherapeutic agent. The T-C formulation enhances delivery of heat and chemo- or radio-therapeutic agents with hyperthermia produced by magnetic nanoparticles to improve therapeutic outcomes. The magnetic nanoparticles and tumorphilic drug carrier also allow for multimodal image-guided monitoring of treatment and patient follow-up. The method for enhanced interventional image-guided therapy for cancer includes using an AMF to heat the T-C formulation and activate the thermotherapy.
    Type: Application
    Filed: April 9, 2012
    Publication date: November 1, 2012
    Applicant: The Johns Hopkins University
    Inventors: Robert Ivkov, Eleni Liapi
  • Patent number: 8300907
    Abstract: An object of the present invention is to easily maintain the couch positioning accuracy and reduce the couch positioning time while resolving the complexity of input operations by the operator at the time of couch positioning. To accomplish the above object, calculation points are set to a CT image at the time of treatment planning, and the 3D coordinates of the set calculation point are set to a DRR image. When a couch positioning unit 115 loads the DRR image from an image server 109, it reads the coordinates of calculation points set to the DRR image and displays them on the monitor 116 together with the DRR image. Further, when DR image data is loaded into the couch positioning unit 115, the DR image is displayed on the monitor 116 and calculation points set to the DRR image are set also to the DR image.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: October 30, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Yoshihiko Nagamine, Toshie Sasaki, Takao Kidani
  • Patent number: 8288745
    Abstract: A novel method of partial breast radiation utilizing a breast implant which can provide a stable and improved target for stereotactic radiation treatment.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: October 16, 2012
    Assignee: Senorx, Inc.
    Inventors: John Corbitt, Lorl Anthony
  • Publication number: 20120253098
    Abstract: An apparatus and method for the treatment of chronic wounds using electromagnetic energy. The apparatus includes a generator and at least one applicator. The generator can produce electromagnetic energy and the applicator can apply the electromagnetic energy produced by the generator. A detector is disposed on the applicator that can measure the field strength of the electromagnetic energy applied.
    Type: Application
    Filed: May 15, 2012
    Publication date: October 4, 2012
    Applicant: Regenesis Biomedical, Inc.
    Inventors: Frank R. GEORGE, Arthur A. Loya, Mary C. Ritz, Robert T. Bryant
  • Patent number: 8269197
    Abstract: The present invention relates to methods and systems for use of an electron beam system. The electron beam system may be used within a treatment center with very little radiation shielding. The electron beam system may be used in conjunction with low-z moderators that reduce the energy level of the electron beam without the need for complex or expensive energy control systems. The electron beam system may be used to treat skin cancer and dermatological patients in non-traditional treatment facilities, as well as invasive cancers, either in an unshielded operating room to deliver intraoperative radiation therapy (“IORT”) or in an unshielded room in the oncology department to deliver electron beam radiation treatment (“EB-RT”).
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: September 18, 2012
    Assignee: Intraop Medical Corporation
    Inventors: Donald A. Goer, Alexandre S. Krechetov
  • Publication number: 20120220812
    Abstract: Disclosed are methods and systems and methods for neuromodulation of the Motor Cortex and other areas of the brain impacted by stroke. The neuromodulation can produce acute effects or result in Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Included is control of direction of the energy emission, intensity, pulse duration, frequency, firing pattern, and phase/intensity relationships to targeting and accomplishing up-regulation and/or down-regulation. The invention can be applied for mitigating the effects of stroke and/or in stroke rehabilitation.
    Type: Application
    Filed: February 26, 2012
    Publication date: August 30, 2012
    Inventor: David J. Mishelevich
  • Publication number: 20120209051
    Abstract: Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
    Type: Application
    Filed: February 14, 2012
    Publication date: August 16, 2012
    Applicant: Seros Medical, LLC
    Inventors: Mark S. Blumenkranz, Edward E. Manche, Satish V. Herekar, Donald J. Eaton
  • Publication number: 20120197061
    Abstract: Catheters configured to deliver magnets for magnetic compression of target tissue have at least one deflatable or retractable tissue spacer and/or radioactive material on the magnet.
    Type: Application
    Filed: December 22, 2011
    Publication date: August 2, 2012
    Inventor: Jay Anthony Requarth
  • Patent number: 8232536
    Abstract: There is provided a particle beam irradiation system so as to provide the dose distribution having more accuracy.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: July 31, 2012
    Assignee: Mitsubishi Electric Corporation
    Inventor: Hisashi Harada
  • Patent number: 8226538
    Abstract: The invention is to a biomedical used multiple-channel hemispherical focused ultrasound phased array apparatus. The invention comprises of a graphic user interface, digital multiple channel phase control kernel, multiple channel driving system, and impedance matching module, power feedback device, as well as the hemispherical low-frequency ultrasound phased array. The invention also serves as a good platform reference to develop a focused ultrasound system in the assisted brain drug delivery application.
    Type: Grant
    Filed: December 10, 2007
    Date of Patent: July 24, 2012
    Assignee: Chang Gung University
    Inventors: Hao-Li Liu, Jhen-Hao Guo, Heng-Wun Chen
  • Patent number: 8207212
    Abstract: Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: June 26, 2012
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, Bernhard Ortel, Eliot F. Battle, Edwin K. Joe
  • Patent number: 8193512
    Abstract: An irradiation field forming device for forming an irradiation field when a specimen is irradiated with a charged particle beam generated by an accelerator, the irradiation field forming device includes: a range shifter arranged on a beam axis of the charged particle beam for regulating an irradiation depth of the charged particle beam; and two or more than two converging electromagnets arranged in the downstream of the range shifter for regulating a beam diameter of the charged particle beam which is enlarged by the range shifter to a constant value.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: June 5, 2012
    Assignee: National Institute of Radiological Sciences
    Inventors: Takuji Furukawa, Kouji Noda
  • Patent number: 8190233
    Abstract: A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: May 29, 2012
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: James F. Dempsey
  • Patent number: 8162812
    Abstract: Combined brachytherapy and ablation devices and methods. A combined brachytherapy and cryotherapy method, includes: inserting an ablation device into tissue of a subject; ablating tissue within an ablation zone of the device; detaching and removing a first part of the device while leaving a second part of the device in the tissue, the first part contacting the ablation zone; and inserting a brachytherapy rod into the second part of the device when the second part is detached from the first part, the brachytherapy rod connected to base at one end and retaining at least one radioactive seed at an opposing end, the brachytherapy rod configured and dimensioned so that when it is inserted into the device up to the base, the at least one radioactive seed is in the ablation zone.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: April 24, 2012
    Assignee: Icecure Medical Ltd.
    Inventors: Eyal Shai, Nir Berzak
  • Patent number: 8140169
    Abstract: An induction heating apparatus includes a first interventional device and a second interventional device. The first interventional device includes an electrically conductive material. The first interventional device is adapted for implantation inside a body and for receiving an alternating current. The second interventional device comprises a magnetically conductive material. The second interventional device is adapted for implantation inside the body in close proximity to the first interventional device. With both devices placed inside the body, the second interventional device magnetically couples with the first interventional device and the second interventional device generates heat upon the application of the alternating current to the first interventional device thereby heating the body site.
    Type: Grant
    Filed: April 5, 2005
    Date of Patent: March 20, 2012
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Barry N. Gellman, Jozef Slanda, Kimberly Paddock
  • Publication number: 20120016174
    Abstract: Systems and methods that could reduce the potential for side effects while delivering a reduced amount of light energy and non-light energy to a patient while providing a desired therapeutic effect that might otherwise only be achievable with a higher dose of either the light energy or non-light energy administered alone are disclosed. In certain embodiments, disclosed is a system and method for treating a patient, by administering a combination of light therapy from a light energy source in addition to one, two, or more other non-light energy modalities to a target region of a patient for a synergistic therapeutic effect.
    Type: Application
    Filed: May 19, 2011
    Publication date: January 19, 2012
    Applicant: Photo Thera, Inc.
    Inventors: Luis De Taboada, Jackson Streeter
  • Patent number: 8079964
    Abstract: An apparatus for inserting a marking element into a marker body includes a body portion, an insertion member, and a pushing member. The body portion has a compartment configured to receive a marker body. The insertion member is configured to engage the marker body within the compartment. The pushing member is configured to engage with the insertion member. The pushing member is operable to force a marking element along the insertion member into the marker body. The insertion member may include a hollow needle configured to penetrate the marker body. The pushing member may include a pin configured to fit within the hollow needle. The marker body may include an opening such as a slit, a slot, or a passage that is configured to receive a marking element. The marker body may include a collagen dowel, and the marking element may be formed of titanium.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: December 20, 2011
    Assignee: Devicor Medical Products, Inc.
    Inventors: Lee E. Reichel, Gwendolyn P. Payne, Trevor W. V. Speeg
  • Patent number: 8075181
    Abstract: A thermal monitoring sheet measures surface temperature distributions of large areas, even over large, contoured surfaces. The sheet incorporates conduits that terminate or intersect at temperature measurement locations with a fixed relative arrangement to form a two-dimensional grid for sensing temperature distributions.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: December 13, 2011
    Assignee: The Regents of the University of California
    Inventors: Paul Rath Stauffer, Celestino John Gaeta, Richard Alan Forber, Doug Peder Bonnell
  • Publication number: 20110301401
    Abstract: The present invention relates to compositions and methods for increasing tissue-radiosensitivity through induction of local hyperthermia. In particular, the present invention provides superparamagnetic, paramagnetic, or ferromagnetic radioactive particles that heat surrounding tissue upon magnetic induction, and methods of use thereof. In some embodiments, the present invention provides compositions and methods for thermoradiotherapy (e.g. anti-tumor therapy).
    Type: Application
    Filed: June 8, 2011
    Publication date: December 8, 2011
    Inventors: Andrew C. Larson, Andrew C. Gordon, Reed A. Omary
  • Patent number: 8053745
    Abstract: A device for circumscribing a target site with a beam. The target site is located within a target body. The path of the beam is varied rotationally so as to form a cone with an isocenter at the cone's apex. The isocenter is fixed on the approximate center of the target site. The target body is rotated about a vertical axis passing approximately through the center of the target site, and the rates of rotation of the beam path and body, respectively correspond so that the beam intersects an axis passing through the target site at an approximately constant angle.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: November 8, 2011
    Inventor: John F. Moore
  • Patent number: 8049187
    Abstract: The present invention provides a charged particle beam irradiating apparatus capable of irradiating a charged particle beam using both a wobbler method and a scanning method. A charged particle beam irradiating apparatus includes: scanning electromagnets that scan a charged particle beam; a wobbler irradiation unit that irradiates the charged particle beam using a wobbler method; a scanning irradiation unit that irradiates the charged particle beam using a scanning method; and a control unit that controls the wobbler irradiation unit and the scanning irradiation unit. In the charged particle beam irradiating apparatus, the control unit operates one of the wobbler irradiation unit and the scanning irradiation unit, and controls the other irradiation unit to be in a withdrawn state so as not to hinder the irradiation of the charged particle beam.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Sumitomo Heavy Industries, Ltd.
    Inventor: Toshiki Tachikawa
  • Publication number: 20110224477
    Abstract: The disclosure relates to a therapeutic device for treatment of a patient, particularly for cancer treatment, which includes a radiation therapy apparatus for applying an ionizing radiation to the patient, and an integrated thermotherapeutic heating device for inducing a regional hyperthermia in the patient.
    Type: Application
    Filed: October 8, 2008
    Publication date: September 15, 2011
    Applicant: Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
    Inventor: Rolf Issels
  • Publication number: 20110160514
    Abstract: A variety of electrical ablation apparatuses and methods are disclosed. In one embodiment, an ablation apparatus includes an injector catheter electrode having a proximal end configured to couple to an energy source and a fluid source. A distal end of the injector catheter defines an injection needle and defines an electrically conductive hollow channel for communicating a fluid from the fluid source to a treatment site. A balloon electrode is in fluid communication with a balloon catheter. The balloon catheter has a proximal end configured to couple to the energy source and the fluid source and a distal end configured to inflate the balloon electrode.
    Type: Application
    Filed: December 31, 2009
    Publication date: June 30, 2011
    Applicant: Ethicon Endo-Surgery, Inc.
    Inventors: Gary L. Long, David N. Plescia, Peter K. Shires
  • Publication number: 20110144410
    Abstract: The invention is directed to a therapy device, including a body, an energy source disposed on the body for emitting a desired wavelength of electromagnetic radiation, and a material dispensing system disposed on the body for dispensing a desired material for use with the device. Also disclosed are accessories and compositions used with the therapy device, including interchangeable energy source-containing heads and interchangeable material containers. Methods for using the therapy device are also disclosed.
    Type: Application
    Filed: August 5, 2005
    Publication date: June 16, 2011
    Inventor: John Kennedy
  • Publication number: 20110124947
    Abstract: Methods for extracting large scale biological, biochemical or molecular information about an index disease, biological state, or systems from imaging by correlating the imaging features associated with said disease, state or system with corresponding large scale biological data.
    Type: Application
    Filed: August 25, 2010
    Publication date: May 26, 2011
    Applicant: MOLECULAR SYSTEMS, LLC
    Inventor: Michael D. Kuo
  • Patent number: 7907987
    Abstract: A device and a process for performing high temporal- and spatial-resolution MR imaging of the anatomy of a patient during intensity modulated radiation therapy (IMRT) to directly measure and control the highly conformal ionizing radiation dose delivered to the patient for the treatment of diseases caused by proliferative tissue disorders. This invention combines the technologies of open MRI, multileaf-collimator or compensating filter-based IMRT delivery, and cobalt teletherapy into a single co-registered and gantry mounted system.
    Type: Grant
    Filed: February 17, 2005
    Date of Patent: March 15, 2011
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: James F. Dempsey
  • Publication number: 20110034752
    Abstract: The invention provides a method for treating cancer in a human comprising (a) administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding a human TNF-? and operably linked to a promoter, wherein the dose comprises about 4×107 to about 4×1012 particle units (pu) of adenoviral vector, at least once in a therapeutic period comprising up to about 10 weeks, (b) administering a dose of ionizing radiation to the human over the duration of the therapeutic period, and (c) administering a dose of one or more chemotherapeutics to the human over the duration of the therapeutic period, whereby the cancer in the human is treated.
    Type: Application
    Filed: September 1, 2010
    Publication date: February 10, 2011
    Applicant: GENVEC, INC.
    Inventors: Paul D. KESSLER, Henrik S. RASMUSSEN, Karen W. CHU
  • Patent number: 7885382
    Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
    Type: Grant
    Filed: June 18, 2007
    Date of Patent: February 8, 2011
    Assignee: Xoft, Inc.
    Inventors: Daren L. Stewart, Paul A. Lovoi, Thomas W. Rusch, Alex Lim, Darius Francescatti
  • Patent number: 7878991
    Abstract: Device and methods for the treatment of wounds using ultrasound energy are disclosed. The portable wound treatment device may deliver ultrasound energy to a wound through direct contact with the ultrasound tip and/or through a liquid coupling medium. Several ultrasound tips specially designed to concentrate and focus ultrasound energy onto a wound are also disclosed. The ultrasound tip may also possess an abrasive peripheral boundary to aid in debriding the wound and/or removing necrotic tissue. The disclosed invention may have multiple beneficial effects in treating a wound such as sterilizing a wound, reducing external bleeding, and/or providing pain relief.
    Type: Grant
    Filed: August 31, 2007
    Date of Patent: February 1, 2011
    Assignee: Bacoustics, LLC
    Inventor: Eilaz Babaev
  • Patent number: 7875861
    Abstract: The invention relates to a positioning device for positioning a patient in a medical device comprising a patient receiving device for placing a patient and a robot arm having a plurality of movement axes for positioning the patient receiving device in a room. The positioning device can be placed into a manual operating mode in which a position of the patient receiving device in the room can be changed manually. The invention also relates to a method for operating the positioning device, comprising: providing a normal operating mode for positioning the patient receiving device automatically at a position predefined by a control device; providing a manual operating mode for manually changing a position of the patient receiving device; and switching from the normal operating mode into the manual operating mode if a switchover condition is present. The invention further relates to an irradiation device having the positioning device.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: January 25, 2011
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Hüttenberger, Eike Rietzel
  • Patent number: 7834334
    Abstract: A particle therapy system for irradiating a volume of a patient to be irradiated with high-energy particles is provided. The system includes a radiation outlet of a radiation delivery and acceleration system from which a particle beam exits in order to interact with the patient positioned in an irradiation position; an imaging device for verifying the position of the volume to be irradiated in relation to the particle beam; and a patient-positioning device with which the patient can be brought into the irradiation position for irradiation. The imaging device checks the position of the volume to be irradiated in an imaging position of the patient that is spatially remote from the irradiation position, and the patient-positioning device automatically changes position between imaging position and irradiation position.
    Type: Grant
    Filed: November 8, 2006
    Date of Patent: November 16, 2010
    Assignee: Siemens Aktiengesellschaft
    Inventors: Sven Oliver Grözinger, Klaus Herrmann, Eike Rietzel, Andres Sommer, Torsten Zeuner
  • Patent number: 7815570
    Abstract: A methodology and system for lysing adipose tissue including directing ultrasonic energy at a multiplicity of target volumes within the region, which target volumes contain adipose tissue, thereby to selectively lyse the adipose tissue in the target volumes and generally not lyse non-adipose tissue in the target volumes and computerized tracking of the multiplicity of target volumes notwithstanding movement of the body.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: October 19, 2010
    Assignee: Ultrashape Ltd.
    Inventors: Yoram Eshel, Ilia Vitsnudel
  • Patent number: 7783006
    Abstract: Methods and apparatus are described for irradiating living tissue via a cavity or lumen, using an inflatable balloon applicator. In a preferred embodiment the applicator balloon has a balloon skin with x-ray contrast material in relatively low concentration, so that an outline of the balloon will appear sharply when imaged externally. In another preferred embodiment the balloon catheter has a drain for withdrawing liquids from the cavity, which may include channels or texture on the exterior of the balloon. Methods are described for using a switchable miniature x-ray tube, variable as to voltage and current, to achieve accuracy in an isodose profile.
    Type: Grant
    Filed: October 8, 2004
    Date of Patent: August 24, 2010
    Assignee: Xoft, Inc.
    Inventors: Daren L. Stewart, Paul A. Lovoi, Thomas W. Rusch, Alex Lim, Darius Francescatti
  • Patent number: 7771339
    Abstract: A method for radiotherapy treatment of a target organ in the vicinity of the rectum in an individual comprises withdrawing the rectum in a dorsal direction to increase a distance between the rectum and the target organ, and administering a therapeutical dose of radiation to the target organ while the rectum is in the withdrawn position. In one embodiment, the target organ is the prostate. A system for use in radiotherapy treatment of a target organ in the vicinity of the rectum in an individual comprises a cylindrical rectal rod adapted for insertion into a rectum of the individual, and a support surface operable to support an individual in a lithotomy position to receive a beam of radiation to the target organ. The system may further include a radiation source for administering a beam of radiation to the target organ of an individual.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: August 10, 2010
    Assignee: AB Mimator
    Inventors: Ulf Isacsson, Kristina Nilsson, Stefan Asplund
  • Patent number: 7762006
    Abstract: A device and corresponding methods for drying medical equipment involving a dryer for drying the medical equipment; and a supply orb having a body and a cavity within the body for holding, ventilating, and storing the medical equipment, the at least one supply orb being mechanically coupled to the dryer for operation and being mechanically decoupled from the dryer during non-operation. The supply orb having a ventilation feature and a configuration conducive to creating a combined irrotational and rotational gas flow therein.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: July 27, 2010
    Assignee: SiestaMed, Technologies
    Inventor: David Kasso
  • Patent number: 7763873
    Abstract: An ion radiation therapy machine provides a steerable beam for treating a tumor within the patient where the exposure spot of the beam is controlled in width and/or length to effect a flexible trade-off between treatment speed, accuracy, and uniformity.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: July 27, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ryan Thomas Flynn, Thomas R. Mackie
  • Patent number: 7755068
    Abstract: Compact particle selection and collimation devices are disclosed for delivering beams of ions with desired energy spectra. These devices are useful with laser-accelerated ion therapy systems, in which the initial ions have broad energy and angular distributions. Superconducting electromagnet systems produce a desired magnetic field configuration to spread the ions with different energies and emitting angles for particle selection. The simulation of ion transport in the presence of the magnetic field shows that the selected ions are successfully refocused on the beam axis after passing through the magnetic field. Dose distributions are also provided using Monte Carlo simulations of the laser-accelerated ion beams for radiation therapy applications.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: July 13, 2010
    Assignee: Fox Chase Cancer Center
    Inventors: Chang Ming Ma, Eugene S Fourkal, Jinsheng Li, Wei Luo
  • Publication number: 20100076246
    Abstract: New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation.
    Type: Application
    Filed: August 19, 2009
    Publication date: March 25, 2010
    Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
  • Patent number: 7659301
    Abstract: Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: February 9, 2010
    Assignee: The General Hospital Corporation
    Inventors: Richard Rox Anderson, Bernhard Ortel, Edwin K. Joe
  • Patent number: 7638779
    Abstract: The invention relates to a radiotherapy assembly comprising a particle emitter (2) with an exit window (4) for a fixed particle stream (6) and a patient support device (16) comprising a patient couch (18A, 18B), which can be brought into an irradiation position that is suitable for irradiating a patient (22) in front of the exit window (4). An X-ray diagnostic device (8) determines or verifies the position of a tumour that is to be irradiated, said device (8) comprising an X-ray source (12) and a detector (14), which can be displaced in the area around the patient couch (18A, 18B) that has been placed in the irradiation position. The assembly permits the location of a tumour to be verified in the irradiation position, thus rendering a relocation of the patient unnecessary.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: December 29, 2009
    Assignee: Siemens Aktiengesellschaft
    Inventor: Klaus Herrmann
  • Patent number: 7637858
    Abstract: A functional sheet which exercises desired actions such as healing effect in high efficiency, without restriction by its use condition and the like is provided. A functional sheet 1 which exercises functions such as healing effect, relaxation effect, decomposition and removal of harmful substances according to complex functions such as generation of minus ions and/or photocatalyst function, by supporting a photocatalyst powder 10 such as titania (TiO2), tin oxide (SnO), zinc oxide (ZnO), SnO2, ZrO2, and WO3 which is oxidized in a structure of which a bond with oxygen is decreased as goes from its surface into the inside gradually, and a radioactive powder 20 containing a natural radioactive substance such as thorium (Th), for example, the powder of monazite, in a condition in which they are mutually brought in contact or adjacent, on a carrier 30 which forms a sheet shape composed by entangling a lot of fibers such as nonwoven fabric.
    Type: Grant
    Filed: April 13, 2005
    Date of Patent: December 29, 2009
    Assignee: Fuji Kihan Co., Ltd.
    Inventor: Yoshio Miyasaka