Bilirubin Patents (Class 600/315)
  • Patent number: 10909835
    Abstract: One or more temperature measuring devices are described that comprise; thermal imaging cameras capable of detection and provision of an exact location of at least one created dynamic image scanned by and triangulated with at least two thermal imaging cameras, and a gate that provides a constrained targeted pathway through which at least one person must travel so that dynamic thermal data of the person is captured as the person is moving through the gate and wherein thermal imaging cameras are geometrically arranged in positions such that the thermal imaging cameras field of view exist on or within the gate and wherein the person is scanned and provides targeted dynamic thermal data that is converted into one or more temperature readings that measure and transmit the temperature readings from one or more photodetectors that sense thermal radiation naturally emitted by people passing through.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: February 2, 2021
    Assignee: TEMPERATURE GATE IP HOLDINGS LLC
    Inventors: Ravindra Pratap Singh, Daniel Maurice Lerner
  • Patent number: 10576475
    Abstract: A cassette removably holds assay strips. The cassette includes a cover and a base. The base includes a first face and a second face, the second face opposed across a thickness of the base from the first face. The base has at least a first channel in the first face that extends along at least a portion of the base, the at least first channel having a width, a length and a depth, at least the width and the depth of the first channel sized to at least partially receive an assay strip therein. The cover has a first face and a second face, the second face opposed across a thickness of the cover from the first face. The cover is releasably securable to the base in at least two orientations to alternatively expose a first set of markings and a second set of markings. The first and the second set of markings are carried by at least one of the cover or the base.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: March 3, 2020
    Assignee: GENPRIME, INC.
    Inventors: Connor S. Kelly, Darby Dawn McLean, Jason Buck Somes
  • Patent number: 10376210
    Abstract: Mouth guards having electrodes, sensors, and/or accelerometers for determining one or more physiological conditions of a subject. Processing circuitry receives the outputs of the electrodes, sensors, and/or accelerometers. Optionally, at least a portion of the processing circuitry can be positioned within a helmet that is worn by a subject. The mouth guard can optionally be tethered to the helmet.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: August 13, 2019
    Assignee: UNIVERSITY OF ALASKA ANCHORAGE
    Inventors: Anthony J. Paris, Jennifer M. Brock, John A. Lund
  • Patent number: 10291893
    Abstract: A diagnosis support apparatus for diagnosing a lesion based on a captured image composed of a multi-valued image, the apparatus includes a dermoscope-equipped image capturing device which captures the captured image; a storage device which stores the captured image; a display which displays the captured image stored in the storage device; and a processor which, under control of a stored program, processes the captured image stored in the storage device.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: May 14, 2019
    Assignee: CASIO COMPUTER CO., LTD.
    Inventor: Mitsuyasu Nakajima
  • Patent number: 10238291
    Abstract: The present invention relates to a quantitative ex vivo method for the complementary diagnosis of the degree of dental demineralization through the use of Raman spectroscopy, which comprises quantifying the intensities and areas of a plurality of Stoke bands of the spectrum, and defining and calculating indices that result from dividing the areas of certain bands of interest. The diagnosis is determined by the proximity of the values of these indices to the values previously obtained for the normal pattern of dental mineralization established by analyzing healthy dental parts. This method provides a complementary biomedical technique for quantitative ex vivo analysis of the degree of dental demineralization on dental tissue remains extracted by medical prescription, and the information obtained will facilitate the prescription of suitable treatment to reduce or prevent said demineralization.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: March 26, 2019
    Assignee: UNIVERSIDADE DE VIGO
    Inventors: Pio Manuel González Fernández, Stefano Chiussi, Benigno Coello Delgado, Maria Rodríguez Domínguez, Miriam López Álvarez, Julia Serra Rodríguez
  • Patent number: 9903869
    Abstract: In order to identify a prostate tumor with a Raman spectroscopy system, at least one Raman spectrum (40) of a sample is detected. The at least one Raman spectrum (40) is evaluated in order to identify a prostate tumor and/or distinguish an aggressive from a non-aggressive prostate tumor based on a characteristic pattern in the at least one Raman spectrum (40).
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: February 27, 2018
    Assignee: CellTool GmbH
    Inventors: Karin Schuetze, Waldemar Lernhardt, Raimund Schuetze
  • Patent number: 9885834
    Abstract: Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about the scattering phase function is preserved. Lens-based and lens-free fiber optic LEBS probes are described that are capable of measuring optical properties of a target tissue through depth-limited measurements of backscattering angles within the enhanced backscattered cone.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: February 6, 2018
    Assignees: NORTHWESTERN UNIVERSITY, AMERICAN BIOOPTICS LLC
    Inventors: Vadim Backman, Jeremy D. Rogers, Nikhil N. Mutyal, Bradley Gould, Andrew J. Radosevich
  • Patent number: 9173603
    Abstract: A transcutaneous non-invasive device and method for measuring bilirubin levels is provided. The device and method utilize optical, electrical, and mechanical means in communication with processing means to calculate the serum bilirubin concentration. Blanching pressure is applied to the tissue, whose thickness is measured. The level of bilirubin is calculated from the thickness of the tissue and the detected and measured values of radiation transmitted through the living tissue.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: November 3, 2015
    Inventors: Jonathan Molcho, Ehud Zmora
  • Patent number: 9086377
    Abstract: An optical system for fluorescence detection includes two parabolic mirrors, a first parabolic mirror and a second parabolic mirror, and fluorescent light beams that are incident from different directions are reflected by the first parabolic mirror as parallel light beams to the second parabolic mirror and are converged at one point by the second parabolic mirror.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: July 21, 2015
    Assignee: Sony Corporation
    Inventor: Yoshiki Okamoto
  • Publication number: 20140323832
    Abstract: A system for detection of bilirubin content in neonate's skin includes at least one camera configured to capture at least one image of neonate's skin and a reference image, a display system, a communication interface and a control unit configured to control functioning of other elements of the system. The control unit is further configured to detect bilirubin level by comparing image of neonate's skin and reference image. Furthermore, the control unit is configured to transfer said image of neonate's skin to at least one of communication interface and display system. The reference image is a single image acquired from any one of the dermal zones or multiple images from more than one dermal zones of neonate under observation.
    Type: Application
    Filed: April 24, 2013
    Publication date: October 30, 2014
    Inventors: Selvaraj Thangaraj, Rajiv Mohan Dhas
  • Publication number: 20140316226
    Abstract: An exemplary system comprises an energy transmitter, an energy receiver, and an analyzer. The energy transmitter may project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user. The energy receiver may generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user. The analyzer may separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and detect, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.
    Type: Application
    Filed: March 14, 2014
    Publication date: October 23, 2014
    Applicant: ECHO LABS, INC.
    Inventors: Elad Ferber, Pierre-Jean Cobut
  • Publication number: 20140303462
    Abstract: A device for applying a sensor to a measurement site on a patient's skin has a wall arrangement defining an applicator volume above the patient's skin The wall arrangement has a patient's side and a sensor side. At least one gas-permeable membrane separates the applicator volume into a first volume directed to the measuring site at the patient's side of the wall arrangement and a second volume separated from the patient's skin and directed to the sensor side of the wall arrangement.
    Type: Application
    Filed: September 25, 2012
    Publication date: October 9, 2014
    Inventors: Christoph Ellenberger-Girard, Dominik Rudmann, Peter Matthias Schumacher
  • Publication number: 20140249390
    Abstract: A process and apparatus for determining the arterial and venous oxygenation of blood in vivo with improved precision. The optical properties of tissue are measured by determination of differential and total attenuations of light at a set of wavelengths. By choosing distinct wavelengths and using the measured attenuations, the influence of variables such as light scattering, absorption and other optical tissue properties is canceled out or minimized.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 4, 2014
    Inventor: Peter Bernreuter
  • Patent number: 8625087
    Abstract: Disclosed herein is a packing container including: a packing container body including a leading-out section which contains an optical probe having a first end section for incoming of a laser beam and a second end section for outgoing of the incoming laser beam, which leads out the first end section of the optical probe thus contained to the exterior and which is sealed, and a window section by which the laser beam going out from the second end section of the contained optical probe is led out to the exterior; and a light-transmitting member which closes the window section and permits the laser beam to pass therethrough.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: January 7, 2014
    Assignee: Sony Corporation
    Inventor: Yoshiro Takiguchi
  • Publication number: 20130094730
    Abstract: Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable.
    Type: Application
    Filed: November 11, 2012
    Publication date: April 18, 2013
    Applicant: CNOGA HOLDINGS LTD.
    Inventor: CNOGA HOLDINGS LTD.
  • Publication number: 20130085351
    Abstract: A tissue analyte measuring device (2) includes a light source (4) structured to emit unpolarized light toward the skin surface of a subject, and a detector assembly (8) configured to receive light reflected the skin surface of the subject and the transcutaneous tissues of the subject, the detector assembly including a polarizing filter (12) and a number of light detector subassemblies (14). The polarizing filter is structured to filter out s-polarized light and pass only p-polarized light to light detector subassemblies. The light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane of the measuring device, wherein the predetermined angle is an angle (the Brewster's angle) at which only s-polarized light will be reflected by the skin surface when the unpolarized light is incident thereon.
    Type: Application
    Filed: April 28, 2011
    Publication date: April 4, 2013
    Applicant: KONINKLIJKE PHILPS ELECTRONICS N.V.
    Inventors: Srinivas Rao Kudavelly, Eduard Johannes Meijer
  • Publication number: 20130023742
    Abstract: A transcutaneous non-invasive device and method for measuring bilirubin levels is provided. The device and method utilize optical, electrical, and mechanical means in communication with processing means to calculate the serum bilirubin concentration. Blanching pressure is applied to the tissue, whose thickness is measured. The level of bilirubin is calculated from the thickness of the tissue and the detected and measured values of radiation transmitted through the living tissue.
    Type: Application
    Filed: July 18, 2012
    Publication date: January 24, 2013
    Inventors: Jonathan MOLCHO, Ehud ZMORA
  • Patent number: 7846121
    Abstract: The invention concerns a device for the extracorporeal irradiation of a patient's (P) bodily fluid containing bilirubin, comprising a first (10) and a second (12) line which can be connected to the patient (P), an impermeable irradiation unit for bodily fluids (14) connected therewith and located between the first (10) and the second (12) lines, and at least one adjustable feed unit for bodily fluids (16) located in the first (10) and/or the second (12) line, wherein by means of at least one feed unit for bodily fluids (16) an adjustable flow of bodily fluid through the lines (10, 12) and the irradiation unit for bodily fluids (14) is achievable, in which the first line (10) is designed to continually circulate the bodily fluid drawn from the patient (P) and route it to the irradiation unit for bodily fluids (14), and the second line (12) is designed to continually circulate the irradiated bodily fluid to the patient (P), and in which the irradiation unit for bodily fluids (14) contains an radiation source fo
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: December 7, 2010
    Assignee: Fresenious Medical Care Deutschland GmbH
    Inventor: Andreas Wuepper
  • Patent number: 7686445
    Abstract: A method and system for monitoring a print drum maintenance system of an image producing machine is disclosed herein in various embodiments. A test pattern is printed on the print drum, and imaged with an image-on-drum detector to determine a printed pattern response. The print drum is then cleaned again imaged with the image-on-drum detector to determine a cleaned print drum response. A cleaning efficiency is computed by comparing the imaged test pattern response to the imaged cleaned print drum response and determining if a failure condition exists by comparing the computed cleaning efficiency to predetermined limits. A corrective process is performed if the failure condition does exist, the corrective process including changing parameters of the drum maintenance system according to the computed cleaning efficiency. The changed parameters are compared to predetermined thresholds and, if not exceeding the thresholds, the cleaning is repeated after the parameters are changed.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: March 30, 2010
    Assignee: Xerox Corporation
    Inventors: Alexander J. Fioravanti, Howard Mizes
  • Publication number: 20090270699
    Abstract: The device serves to optically determine physiological variables in perfused tissue. The device comprises a first and a second light source which each emit light radiation of a first or a second predetermined wavelength. The light sources are arranged in such a manner that the light radiation exiting them can penetrate into the perfused tissue. At least one photodetector is used, which is arranged so that it detects the light emitted by the light sources and passing through or backscattered by the perfused tissue. The device also comprises a control unit, which furnishes control signals to the light sources so that the light sources continuously emit light alternately, one or more dark phases can be inserted into this sequence, during which at least one light source does not emit any light.
    Type: Application
    Filed: November 2, 2006
    Publication date: October 29, 2009
    Inventors: Bernd Scholler, Thomas Magin, Klaus Forstner
  • Publication number: 20090131771
    Abstract: The present invention provides a bilirubin reducing means which can minimize a risk such as the onset of an infection or the occurrence of blood coagulation and can reduce physical, temporal and economical burdens imposed on a patient suffering from liver dysfunction.
    Type: Application
    Filed: June 30, 2006
    Publication date: May 21, 2009
    Inventors: Yoshimasa Takeda, Kiyoshi Morita
  • Publication number: 20090054745
    Abstract: Method and system for providing diabetes related data management is provided.
    Type: Application
    Filed: August 7, 2006
    Publication date: February 26, 2009
    Applicant: Abbott Diabetes Care, Inc.
    Inventor: R. Curtis Jennewine
  • Publication number: 20090048500
    Abstract: A non-invasive monitoring system using radiated energy to identify cardiac and respiratory waveforms in patients is discussed. The monitoring system illuminates a subject in radiated energy and then detects the reflected radiated energy caused by respiratory and/or cardiac functions. The detected reflections are used to plot a two-dimensional waveform. The waveforms represent the rise and fall of a detected signal (the reflected energy) over time and are indicative of the small movements of the patient's chest and abdomen that are associated with cardiac and respiratory function. Different implementations of the monitoring system use laser or ultrasonic energy to capture breathing and cardiac waveforms for analysis. The waveforms may be used to diagnose the effectiveness of prescribed sleep medication, perform remote line of sight monitoring from a remote location, identify crying waveforms for babies and infants, identify cardiac waveforms in a non-invasive manner and identify seizure and tremor activity.
    Type: Application
    Filed: April 20, 2006
    Publication date: February 19, 2009
    Applicant: RESPIMETRIX, INC.
    Inventor: Stephen Bruce Corn
  • Patent number: 7454044
    Abstract: A method is presented to calculate the relative contribution of different tissues, or tissue mix, to at least one data element in a medical object data set, the medical object data set containing data elements, the data elements assigning data values to respective positions in a multi-dimensional geometrical space containing more than one tissue, by means by which parameters are calculated for the at least one data element, the parameters being dependent on the data value of the at least one data element and data values of surrounding data elements in the neighborhood of the at least one data element, the parameters being further compared to combinations of said parameters for data elements occurring in the region of boundaries between tissues.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: November 18, 2008
    Assignee: Koninkklijke Philips Electronics, N.V.
    Inventors: Roel Truyen, Steven Lobregt, Iwo Willem Oscar Serlie
  • Publication number: 20080214911
    Abstract: The method and the device according to the invention are used for the non-invasive measurement of concentrations of blood components. At least one light source generates light using spectrophotometry and the light is guided to at least one photodetector through a tissue present at the location of application and supplied with pulsating blood. At least the measuring signal of the photodetector is guided to an evaluation unit. The light signals of a first, second, third to (n+1)st wavelength are generated at subsequent pairwise times T1 and T2, T3 and T4 and T5 and T6 to Tn and Tn+1. The evaluation unit takes into consideration the received signals of the photodetector for all wavelengths according to a defined arithmetic pattern and determines a concentration of the blood component. The inventive device comprises at least three light sources that generate light of different wavelength in relation to each other.
    Type: Application
    Filed: March 15, 2004
    Publication date: September 4, 2008
    Inventor: Klaus Forstner
  • Patent number: 7388110
    Abstract: A fluorescent monomer compound represented by the following formula (1) is provided: wherein Q, Q? and D3 may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; and D1, D2 and D4 each represent a substituent, wherein at least one of D1, D2 and D4 is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: June 17, 2008
    Assignee: Terumo Kabushiki Kaisha
    Inventors: Shouji Ochiai, Tetsuro Kawanishi, Atsushi Matsumoto
  • Publication number: 20080113337
    Abstract: The present invention provides a method and device of quantitatively or qualitatively examining and judging the presence of virus infection, such as HIV, or the presence of prion infection by: irradiating a sample derived from an examinee or other animal with light having a wavelength in a range of 400 nm to 2500 nm or a wavelength in part of the range; detecting reflected light, transmitted light, or transmitted and reflected light to obtain an absorption spectral data; and analyzing the absorbance at all measurement wavelengths or at specific wavelengths in the absorption spectral data by using an analytical model prepared beforehand. The analytical model can be prepared by carrying out spectral measurement, with a perturbation being provided, and carrying out a multivariate analysis that brings out perturbation effects.
    Type: Application
    Filed: November 10, 2005
    Publication date: May 15, 2008
    Applicants: THE NEW INDUSTRY RESEARCH ORGANIZATION, OSAKA UNIVERSITY
    Inventors: Akikazu Sakudo, Roumiana Tsenkova, Kazuyoshi Ikuta, Takashi Onodera
  • Publication number: 20080058619
    Abstract: Embodiments of methods, apparatuses, systems and/or devices for active biometric spectroscopy are disclosed.
    Type: Application
    Filed: September 6, 2006
    Publication date: March 6, 2008
    Inventor: Donald Martin Monro
  • Publication number: 20070298487
    Abstract: An assay transponder is disclosed. The assay transponder has an RF transceiver that allows the assay transponder to communicate wirelessly with another RF device. The transponder also has a sensor that interrogates an assay associated with the transponder. The assay exhibits a response to a sample environment in which the transponder is placed. The transponder communicates the results of the assay interrogation to the other RF device by modulating a signal indicative of the results onto an RF carrier signal and transmitting the signal via an antenna.
    Type: Application
    Filed: June 23, 2006
    Publication date: December 27, 2007
    Applicant: Becton, Dickinson and Company
    Inventors: Nicholas R. Bachur, Paul Goldenbaum, Robert Rosenstein, Timothy Hansen
  • Publication number: 20070282179
    Abstract: A method of optically analyzing tissue in vivo in an individual to obtain a unique spectrum for the tissue of the individual includes the steps of optically measuring the tissue of the individual using broadband diffuse optical spectroscopy (DOS) to measure a normalized tissue water spectrum of the individual or noninvasively optically line scanning a tissue site on the individual at a plurality of points, then determining spectral differences between the normalized tissue water spectrum and a pure water spectrum at each point of a line scan, generating a bound water index (BWI) corresponding to the spectral differences, and identifying a tissue state corresponding to the scanned tissue based on the BWI.
    Type: Application
    Filed: June 4, 2007
    Publication date: December 6, 2007
    Applicant: The Regents of the University of California
    Inventors: Sean Merritt, Bruce J. Tromberg, Albert E. Cerussi, Anthony J. Durkin, So Hyun Chung
  • Publication number: 20070270675
    Abstract: In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 22, 2007
    Inventors: Michael John Kane, Jeffrey Allen Von Arx, James Gregory Bentsen, Jonathan Kwok
  • Publication number: 20070270674
    Abstract: In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
    Type: Application
    Filed: May 17, 2006
    Publication date: November 22, 2007
    Inventors: Michael John Kane, Jeffrey Allen Von Arx, James Gregory Bentsen
  • Publication number: 20070264625
    Abstract: The invention describes a treatment for skin containing selected targets that provides feedback in response to a measurement enabled by the ablation of holes. The inventive apparatus includes an electromagnetic source configured to emit ablative electromagnetic energy, a delivery system, a sensing element, and a controller. The delivery system can be configured to receive ablative energy from the electromagnetic source and deliver it to multiple discrete locations at the selected region to form a pattern of discrete holes in epidermal and dermal tissue of the skin. The lipid content a portion of the tissue can be evaluated using a sensing element. At least one pulse of electromagnetic energy is delivered to the skin under control of a controller in response to the result of a measurement by the sensing element. The apparatus may include a positional sensor to provide additional dosage control, particularly when the inventive method is used with a continuously movable handpiece.
    Type: Application
    Filed: May 11, 2007
    Publication date: November 15, 2007
    Applicant: RELIANT TECHNOLOGIES, INC.
    Inventors: Leonard C. DeBenedictis, George Frangineas
  • Patent number: 6927843
    Abstract: The invention concerns a method and a device for non-invasive measurement of a tissue and in particular of the skin bilirubin level. The inventive device is characterized in that it comprises: a reading head (1) capable of sending several flashes of various specific wavelengths towards the tissue (2) to be examined and of receiving and measuring in return the reflected light; a calculator, such as a microprocessor, capable of calculating for each wavelength the amount of reflected light and bring it to a value calculated proportionally to a reference value identical for a predetermined wavelength; and a comparator for comparing the calculated value to a table of reference values.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: August 9, 2005
    Assignee: Medick S.A.
    Inventor: Jean-Michel Dick
  • Patent number: 6882873
    Abstract: A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: April 19, 2005
    Assignee: Respironics, Inc.
    Inventors: Mark A. Samuels, Keith D. Ignotz, Gregory J. Newman, Jonathan A. Eppstein, Fan Xu
  • Patent number: 6852500
    Abstract: The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe (10) inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell (16) to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device (18, 20) in accordance with a command variable derived from the measurement signals of the measuring cell (16). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: February 8, 2005
    Assignee: Roche Diagnostics GmbH
    Inventors: Udo Hoss, Hans-Joerg Pfleiderer, Ralf Gessler, Hans-Ulrich Zieten, Rolf Fussgaenger
  • Patent number: 6847835
    Abstract: Luminous fluxes from a xenon tube are introduced from one end of an optical fiber to an other end thereof and emerge therefrom. These luminous fluxes are incident of a skin of a person to be measured, and those diffused in the skin are incident on one end of an optical fiber through a first incident port and on one end of an optical fiber through a second incident port. The luminous fluxes from the one end are split by a dichroic mirror. The luminous fluxes reflected by the dichroic mirror are received by a photoelectric conversion element via a blue filter, and those having transmitted through the dichroic mirror are received by a photoelectric conversion element via a green filter. A concentration of bilirubin pigmented in fat of subcutaneous tissues can be accurately measured without being influenced by a difference in the thicknesses of epidermis and derma.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: January 25, 2005
    Assignee: Minolta Co., Ltd.
    Inventor: Akio Yamanishi
  • Publication number: 20040267102
    Abstract: An automated dermatological examination system captures an image including a lesion. The image is divided into lesion and non-lesion areas, and the lesion area is analysed to quantify features for use in diagnosis of the lesion. Features of lesion colour are extracted (step 502) and the shape of the lesion is analysed (step 504). Features of lesion texture and symmetry are derived (step 506) as are measures of categorical symmetry within the lesion (step 508).
    Type: Application
    Filed: August 30, 2004
    Publication date: December 30, 2004
    Inventors: Victor Nickolaevick Skladnev, Alexander Gutenev, Scott Menzies, Leanne Margaret Bischof, Gustave Francois Talbot, Edmond Joseph Breen, Michael James Buckley
  • Publication number: 20040242976
    Abstract: Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body. Signals are transmitted to a remote station by wireless transmission such as by electromagnetic waves, radio waves, infrared, sound and the like or by being reported locally by audio or visual transmission. The physical and chemical parameters include brain function, metabolic function, hydrodynamic function, hydration status, levels of chemical compounds in the blood, and the like. The support structure includes patches, clips, eyeglasses, head mounted gear and the like, containing passive or active sensors positioned at the end of the tunnel with sensing systems positioned on and accessing a physiologic tunnel.
    Type: Application
    Filed: February 26, 2004
    Publication date: December 2, 2004
    Inventor: Marcio Marc Abreu
  • Publication number: 20040242977
    Abstract: A non-invasive method of determining the concentration of an analyte comprises topographically applying a hyperosmotic solution to an area of the skin. The hyperosmotic solution is adapted to at least partially absorb into the area of the skin such that the skin becomes generally transparent. An optical readhead is placed over the generally transparent area of the skin. The amount of light of the analyte is measured using at least one wavelength via the optical readhead. The concentration of the analyte is calculated from the amount of light. The analyte may be glucose and the hyperosmotic solution may be glycerol.
    Type: Application
    Filed: May 17, 2004
    Publication date: December 2, 2004
    Inventor: Andrew J. Dosmann
  • Publication number: 20040214156
    Abstract: The invention provides an apparatus and methods for determining whether spectral data obtained from a region of a tissue sample are affected by an artifact. Artifacts include, for example, lighting artifacts such as glare and shadow and obstruction artifacts, such as blood, a speculum, a smoke tube, or other obstruction. Additionally, the invention provides an apparatus and methods for obtaining redundant spectral data of a given region of a sample. A redundant set of spectral data is useful where one or more artifacts affect some but not all sets of the spectral data, such that the redundant set of data is unaffected by the artifact and is representative of the tissue. An embodiment of the invention comprises using representative spectral data in diagnosing a condition of a region of tissue.
    Type: Application
    Filed: May 19, 2004
    Publication date: October 28, 2004
    Applicant: MediSpectra, Inc.
    Inventors: Kevin T. Schomacker, Thomas Meese, Michael Ouradnik, John Flanagan, Harry Gao
  • Publication number: 20040209237
    Abstract: The invention provides a system and methods for in-situ identification of one or more regions of tissue at which there is a likelihood of disease. The invention generally relates to methods and devices for acquiring, analyzing, processing, and displaying optical data and diagnostic results from a patient sample. For example, methods of the invention comprise obtaining spectral and visual data from a patient sample, calibrating the data, compensating for sample motion, arbitrating between redundant data sets, identifying potentially non-representative data, analyzing the data, and displaying the diagnostic results. The invention provides the option of real-time data processing and diagnosis.
    Type: Application
    Filed: April 18, 2003
    Publication date: October 21, 2004
    Applicant: MediSpectra, Inc.
    Inventors: Ross F. Flewelling, Peter J. Costa, Stephen T. Sum, Kevin T. Schomacker, Chunsheng Jiang, Thomas R. Clune
  • Patent number: 6596016
    Abstract: A phototherapy garment contains a flexible backing material, a transparent liner, and a flexible printed circuit sheet containing surface-mounted light-emitting diodes (LEDs) positioned between the backing material and the liner. An infant is placed inside the garment so that the LEDs illuminate a large portion of the infant's skin for phototherapy. The LEDs preferably emit high-intensity blue light, suitable for treatment of neonatal hyperbilirubinemia or Crigler-Najjar syndrome. The LEDs are arranged in a densely packed array facing the liner and emit uniform, high intensity light. A power supply, which may be portable, supplies adjustable power to the LEDs, preferably pulsed with a duty cycle of approximately 10%, and preferably to overdrive the LEDs to maximize light output. A two-way communications device incorporated into the garment allows a physician or computer to control the garment remotely and gather relevant information periodically or continuously.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: July 22, 2003
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Hendrik J. Vreman, Daniel S. Seidman, David K. Stevenson
  • Publication number: 20030109773
    Abstract: A system and method embodying the invention can be used to detect a characteristic or condition of a patient. A method embodying the invention may include the steps of illuminating a portion of a skin of the patient with light, detecting a frequency spectrum of light scattered from the skin, determining, from first and second portions of the spectrum, a first parameter indicative of a blood content of the skin and a second parameter indicative of a melanin content of the skin, determining, from a third portion of the spectrum, a third parameter indicative of an uncorrected bilirubin concentration, and calculating a corrected bilirubin concentration based on the first, second and third parameters.
    Type: Application
    Filed: November 26, 2002
    Publication date: June 12, 2003
    Applicant: SpectRx, Inc.
    Inventors: Mark A. Samuels, Keith D. Ignotz, Gregory J. Newman, Jonathan A. Eppstein, Fan Xu
  • Publication number: 20030011773
    Abstract: The invention concerns a method and a device for non-invasive measurement of a tissue and in particular of the skin bilirubin level. The inventive device is characterized in that it comprises: a reading head (1) capable of sending several flashes of various specific wavelengths towards the tissue (2) to be examined and of receiving and measuring in return the reflected light; a calculator, such as a microprocessor, capable of calculating for each wavelength the amount of reflected light and bring it to a value calculated proportionally to a reference value identical for a predetermined wavelength; and a comparator for comparing the calculated value to a table of reference values.
    Type: Application
    Filed: August 6, 2002
    Publication date: January 16, 2003
    Inventor: Jean-Michel Dick
  • Patent number: 6192734
    Abstract: A combined infection shield and calibration or reference target for use with a measuring instrument includes a removable calibration/reference layer. The removable calibration/reference layer has predetermined optical characteristics that can be utilized to calibrate or reference the instrument. When the calibration/reference layer is removed from the remaining portions of the device, the portion of the calibration/reference layer having the predetermined optical characteristics is irrevocably altered such that the calibration/reference layer cannot be reused. The combined infection shield and target may be attached to a shield holder, which in turn is attached to an instrument. Alternatively, the infection shield and target may be attached directly to an instrument. The target may include a calibration/reference layer having a reduced strength portion which causes the target to tear or separate in a predetermined manner.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: February 27, 2001
    Assignee: SpectRx, Inc
    Inventors: Robert Rothfritz, Scott Kerr, Glenn Steven Arche, Scott Kellogg, Gregory J. Newman, Mark A. Samuels, Richard Lachlan Fowler
  • Patent number: 6129664
    Abstract: A method and apparatus for determining the condition of a test subject based on color uses a color measuring instrument to detect change in a color factor indicative of a condition such as a disease, spoilage, ageing, etc. A medical condition such as bilirubinemia that affects skin color can be detected. One measures color factors such as Hunter b and L in the subjects' skin color. For predetermined ranges of one color factor, in particular L, changes in the other color factor, e.g. Hunter b, above predetermined levels are indicative of the medical condition. In many cases, a single measurement of the color factors can be utilized as a warning of the likelihood of the medical or contaminated condition, if the ordinary range of the color factor is known for healthy individuals with skin coloration like that of the test subject.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: October 10, 2000
    Assignee: Chromatics Color Sciences International, Inc.
    Inventors: Darby Simpson Macfarlane, David Kenneth Macfarlane, Fred W. Billmeyer, Jr.
  • Patent number: 6128516
    Abstract: A method and apparatus for determining the condition of a test subject based on color uses a color measuring instrument to detect change in a color factor indicative of a condition such as a disease, spoilage, ageing, etc. A medical condition such as bilirubinemia that affects skin color can be detected. One measures color factors such as Hunter b and L in the subjects' skin color. For predetermined ranges of one color factor, in particular L, changes in the other color factor, e.g. Hunter b, above predetermined levels are indicative of the medical condition. In many cases, a single measurement of the color factors can be utilized as a warning of the likelihood of the medical or contaminated condition, if the ordinary range of the color factor is known for healthy individuals with skin coloration like that of the test subject.
    Type: Grant
    Filed: September 29, 1997
    Date of Patent: October 3, 2000
    Assignee: Chromatics Color Sciences International Inc.
    Inventors: Darby Simpson Macfarlane, David Kenneth Macfarlane, Fred W. Billmeyer, Jr.
  • Patent number: 6045502
    Abstract: A system and method for calibrating a measurement instrument prior to making a measurement on a material or tissue includes utilizing a removable calibration device to calibrate the instrument, then removing a target portion of the calibration device so that a measurement may be performed. The calibration device may include an index matching agent, such as a gel, that is to be interposed between the patient's skin and an output end of the measuring instrument. A method embodying the invention may include making a bilirubin concentration measurement on a skin of a patient by measuring the amplitude of light reflected from the patient's skin at first and second wavelengths indicative of a blood content of the patient's skin, and measuring the amplitude of reflected light at a third wavelength indicative of an uncorrected bilirubin concentration, then calculating a corrected bilirubin concentration based on the three measurements.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: April 4, 2000
    Assignee: SpectRx, Inc.
    Inventors: Jonathan A. Eppstein, Mark A. Samuels, Keith D. Ignotz, Gregory J. Newman
  • Patent number: 5933226
    Abstract: An attachment is designed such that a concentration measuring apparatus is attachable to and detachable from it. Inside the leading end portion of the attachment, leading ends of two light guide members are provided opposite to each other so as to hold a micro cuvette mounted on the attachment. One light guide member guides light from a light source of the concentration measuring apparatus to subject matter in the micro cuvette while the other guides light from the subject matter to light receiving elements of the concentration measuring apparatus. The concentration measuring apparatus calculates a concentration of the subject matter based on respective outputs from the light receiving elements.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: August 3, 1999
    Assignee: Minolta Co., Ltd.
    Inventor: Akio Yamanishi