By Fluorescent Emission Patents (Class 600/317)
  • Patent number: 11872023
    Abstract: A method of assessment of microcirculation oscillations comprises illumination of a selected location on non-hairy skin of a human subject in a resting steady condition without any blockage or stimulation of the blood flow with exciting light capable of inducing skin NADH fluorescence signal for a period of time; simultaneously with said illumination detecting, measuring and recording as a function of time the induced NADH fluorescence signal emitted from the said selected location to obtain the time course of the NADH fluorescence signal intensity in the said period of time; and computer implemented steps of: fitting of a baseline about which the NADH fluorescence signal oscillates to the said time course of the NADH fluorescence signal; and determination of a mean squared error of the deviation of the NADH fluorescence signal from the fitted baseline as a parameter of oscillatory function of the skin microcirculation.
    Type: Grant
    Filed: April 23, 2019
    Date of Patent: January 16, 2024
    Assignee: ANGIONICA SP. Z O.O.
    Inventors: Jerzy Gebicki, Andrzej Marcinek
  • Patent number: 11832797
    Abstract: Systems and methods are configured for combined fluorescence imaging and white light imaging of tissue such as during surgical endoscopic procedures. A chip-on-tip type endoscope can be equipped with both white light and blue light LEDs. A single camera or dual cameras are configured with backside illuminated CMOS image sensor(s) to receive and process the white light and fluorescence images. The light sources, image sensors and image processing circuitry are configured to synchronously emit light and record pixels for visible white light and fluorescence frames alternately. Global or quasi-global shuttering can be used on the image sensor(s). A modified color filter array and other filters can be provided to enhance fluorescence imaging capabilities. Insufflating gas clears debris from the camera field of view and aids in moving the cannula distally through a body passageway.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: December 5, 2023
    Assignee: MicronVision Corp.
    Inventor: Xiaolong Ouyang
  • Patent number: 11766193
    Abstract: A biosensor for measuring a physiological signal representative of a physiological parameter associated with an analyte is described. The biosensor includes a working electrode and a counter electrode. The counter electrode including a silver and a silver halide having an initial amount, wherein the initial amount is determined by the following steps of defining a required consumption range of the silver halide during at least one of the measurement periods performed by the biosensor; and determining the initial amount based on a sum of an upper limit of the required consumption range and a buffer amount, so that a required replenishment amount range of the silver halide during the replenishment period is controlled to be sufficient to maintain an amount of the silver halide within a safe storage range.
    Type: Grant
    Filed: August 3, 2020
    Date of Patent: September 26, 2023
    Inventors: Chun-Mu Huang, Chieh-Hsing Chen
  • Patent number: 11707321
    Abstract: The disclosed invention provides a transseptal insertion device which is suitable for facilitating precise and safe transseptal puncture of a cardiac interatrial septum. The transseptal insertion device includes a sheath that defines at least one lumen therein, one or more positioning balloons that are connected to a distal end of the sheath, a puncture member movably positioned within the at least one lumen, and a puncture member balloon located on the puncture member. The sheath has one or more deflation ports to deflate the one or more positioning balloons. The puncture member balloon, when inflated, is capable of sealing the one or more deflation ports in the sheath, permitting the inflation of the one or more positioning balloons. When the puncture member moves toward fossa ovalis, the inflated puncture member balloon moves away from the deflation ports, allowing the positioning balloons to be deflated.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: July 25, 2023
    Assignee: East End Medical, LLC
    Inventor: Brijeshwar S. Maini
  • Patent number: 11627871
    Abstract: A medical-endoscopic instrument includes a distal elongate insertion section (1), for the minimal-invasive introduction into a human or animal body, with a first LED (5), a second LED (7) and a picture sensor (9). The first LED includes a first light spectrum (19), suitable for fluorescence endoscopy. The second LED includes a second light spectrum (21), suitable for white light endoscopy. A light filter (23), arranged in front of the second LED in the viewing direction (x), has a transmission spectrum (25). The second LED is configured to irradiate according to the second light spectrum on average more intensively in a first wavelength region (K) than in a second wavelength region (L). The light filter is configured to let through light, which is emitted by the second LED, according to the transmission spectrum, on average less in the second wavelength region than in the first wavelength region.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: April 18, 2023
    Inventors: Bernd Claus Weber, René Handte, Alessandro Impellizzeri, Martin Dolt
  • Patent number: 11612309
    Abstract: Hyperspectral videostroboscopy imaging is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a controller configured to cause the emitter to emit the pulses of electromagnetic radiation at a strobing frequency determined based on a vibration frequency of vocal cords of a user. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, or from about 900 nm to about 1000 nm.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: March 28, 2023
    Inventors: Joshua D. Talbert, Donald M. Wichern
  • Patent number: 11602301
    Abstract: The wheal and flare analyzing system analyzes the mast cell reaction to an allergen being administered in a scratch or prick skin test. The system comprises a sensor array and a processing unit. The sensor array includes a plurality of emitters surrounding a receiver at the allergen test site. Energy of various wavelengths is emitted into the allergen test site. An energy receiver measures reflected various wavelengths from the plurality of emitters. A microprocessor is in digital communication with the plurality of emitters and the energy receiver. The reflected wavelengths have an energy return indicative of the intensity of the allergic reaction in the mast cells. The intensity of the allergic reaction is analyzable from the reflected wavelengths and other data over time. A plurality of temperature sensors measuring local dermal temperatures surrounding the sensor array, the local dermal temperature being indicative of the intensity of the allergic reaction.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: March 14, 2023
    Inventor: C. Bruce Banter
  • Patent number: 11553879
    Abstract: Certain embodiments described herein pertain to optical sensors, systems and methods for continuous glucose monitoring. In some embodiments, methods of preparing a layered optical sensor are disclosed. The optical sensor can be formed by laminating a plurality of sheets together to form a final sensor. In some embodiments, the sensor tip comprises a oxygen conduit, an enzymatic layer, and an sensing layer. In some embodiments, the sensor includes a plurality of waveguides configured to direct light to and from a target material, such as an oxygen sensing polymer. Systems are also disclosed for an adhesive system for attaching an optical sensor-transmitter system. Methods and systems are also disclosed for a sensor inserter system. The inserter can include a lancet tip that includes a convex feature attached to a first surface of the lancet tip.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: January 17, 2023
    Assignee: Metronom Health, Inc.
    Inventor: Troy M. Bremer
  • Patent number: 11477390
    Abstract: Systems, methods, and devices for fluorescence imaging with a minimal area image sensor are disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation, wherein the pixel array comprises active pixels and optical black pixels. The system includes a black clamp providing offset control for data generated by the pixel array and a controller comprising a processor in electrical communication with the image sensor and the emitter. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 770 nm to about 790 nm; or electromagnetic radiation having a wavelength from about 795 nm to about 815 nm.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: October 18, 2022
    Inventors: Joshua D. Talbert, Donald M. Wichern
  • Patent number: 11272830
    Abstract: Provided is an endoscope system capable of easily re-searching for a detected region of interest, and an operation method for the endoscope system. An endoscope system 10 includes an endoscopic image acquisition unit 54, a region-of-interest detecting unit 80, a position information acquisition unit 81, and a display unit 18. The endoscopic image acquisition unit 54 acquires an endoscopic image acquired by capturing an image of a lumen with an endoscope 12. The region-of-interest detecting unit 80 detects a region of interest in the lumen by using the endoscopic image. The position information acquisition unit 81 acquires position information of the region of interest detected by the region-of-interest detecting unit 80. The display unit 18 displays the position information of the region of interest.
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: March 15, 2022
    Assignee: FUJIFILM Corporation
    Inventor: Shumpei Kamon
  • Patent number: 11266345
    Abstract: A tissue imaging system comprising a computing device, tissue visualization application, image capturing unit, and an illumination unit, is configured to capture measurement data. The visualization application extracts visualizations of tissue health indicators from the measurement data. The application generates an interface with one or more interface elements corresponding to the visualization of tissue health indicators.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: March 8, 2022
    Assignee: Swift Medical Inc.
    Inventors: Guennadi Saiko, Kenneth Macko, Andrei Betlen
  • Patent number: 11262267
    Abstract: A method for testing an optical assembly (1) which has an optical microstructure (3) integrated with a substrate (2). The optical microstructure (3) is positioned to form an external optical interaction area (4) on a part of a surface (5) of the substrate (2). A cover cap (6) seals at least a part of the surface (5) of the substrate (2) adjacent to the optical microstructure (3) to obtain a sealed cavity (9). An optical feedthrough (10) is integrated in the substrate (2) to form an external communication path from within the sealed cavity (9). The optical feedthrough (10) allows communication of a physical parameter value which is measured inside the sealed cavity (9) to outside the sealed cavity (9). The physical parameter value is associated with a measure of hermeticity of the sealed cavity (9).
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: March 1, 2022
    Assignee: Indigo Diabetes N.V.
    Inventors: Danaë Delbeke, Paolo Cardile, Juan Sebastian Ordonez Orellana, Ananth Subramanian
  • Patent number: 11202606
    Abstract: A system for detection of optically anisotropic tissue is provided. The system comprises an optical source, an optical detector, a processing unit and a probe. The probe has a shaft with a longitudinal axis and a front end, and a plurality of optical fibers; wherein an end of each of the optical fibers is arranged at the front end of the shaft, and at least one of the optical fibers is a source optical fiber adapted to transmit optical radiation emitted from the optical source to a tissue adjacent to the front end of the shaft. Another one of the optical fibers is a detector optical fiber adapted to transmit optical radiation reflected from the tissue to the optical detector, so that an optical path through the tissue is defined, wherein the optical paths differ from each other with respect to their spatial orientation, and wherein the optical paths cross each other.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: December 21, 2021
    Inventors: Manfred Mueller, Bernardus Hendrikus Wilhelmus Hendriks, Gerhardus Wilhelmus Lucassen, Torre Michelle Bydlon
  • Patent number: 11187689
    Abstract: A method and apparatus for monitoring a product is provided, the sensor includes a first sensor element formed from a first biodegradable material and having a first sensor element height, wherein the first sensor element height changes in response to a first parameter of interest of the product.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: November 30, 2021
    Inventors: Renee A. Eddy, David C. Brondum, Mark E. Cywilko, Richard P. Marcantonio, James Taeckens, Jeffrey Allen Leshuk
  • Patent number: 11131584
    Abstract: A sensor device may determine a first optical sensor value associated with a first displacement and a second optical sensor value associated with a second displacement, wherein the first displacement is between an emitter associated with the first optical sensor value and a sensing location used to determine the first optical sensor value, wherein the second displacement is between an emitter associated with the second optical sensor value and a sensing location used to determine the second optical sensor value, and wherein the first displacement is different from the second displacement. The sensor device may determine one or more measurements using the first optical sensor value and the second optical sensor value, wherein the one or more measurements relate to a first penetration depth associated with the first optical sensor value, and a second penetration depth associated with the second optical sensor value.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: September 28, 2021
    Assignee: VIAVI Solutions Inc.
    Inventors: Valton Smith, William D. Houck, Curtis R. Hruska, Marc K. Von Gunten
  • Patent number: 11013414
    Abstract: A multispectral synchronized imaging system is provided. A multispectral light source of the system includes: blue, green and red LEDs, and one or more non-visible light sources, each being independently addressable and configured to emit, in a sequence: at least visible white light, and non-visible light in one or more given non-visible frequency ranges. The system further includes a camera and an optical filter arranged to filter light received at the camera, by: transmitting visible light from the LEDs; filter out non-visible light from the non-visible light sources; and otherwise transmit excited light emitted by a tissue sample excited by non-visible light. Images acquired by the camera are output to a display device. A control unit synchronizes acquisition of respective images at the camera for each of blue light, green light, visible white light, and excited light received at the camera, as reflected by the tissue sample.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: May 25, 2021
    Inventors: Ze Shan Yao, Piotr Kuchnio, Michael Frank Gunter Wood, Tammy Kee-Wai Lee, Yanhui Bai, Michael Peter Bulk, Christopher Thomas Jamieson
  • Patent number: 10983323
    Abstract: A fluorescence observation device includes: a first intensity-modulating unit that intensity-modulates, at a frequency f1, pump light that excites fluorescence of an observed subject; a second intensity-modulating unit that intensity-modulates, at a frequency f2 different from the frequency f1, probe light that induces stimulated emission of the observed subject; a light-receiving unit that receives the fluorescence from the observed subject irradiated with the intensity-modulated pump light and probe light; and a sensing unit that senses a component with a frequency of i×f1±j×f2 (i and j are positive integers, at least one of which is equal to or larger than two) in a reception-light signal sensed at the light-receiving unit.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: April 20, 2021
    Inventor: Fumihiro Dake
  • Patent number: 10945615
    Abstract: A device and method is provided for a suction tool combined with an optical probe. A suction device is provided having a tip with a hollow tubular body, a plurality of optical fibers embedded in the tip and a concentric ring attached to the tip, wherein the ring end has an inner beveled reflective surface opposing the optical fibers. A method is provided for optically measuring tissue in a medical procedure comprising suctioning a tissue using a suction device, sending optical signals along optical fibers through the suction device; directing the signals from the optical fibers onto the tissue using a beveled surface; receiving optical signals from the tissue in optical fibers via the beveled reflective surface; measuring the received optical signals in a spectrometer or detector; and releasing, resecting or ablating the tissue through the suction device.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 16, 2021
    Inventors: Kresimir Franjic, Luc Gilles Charron, Siu Wai Jacky Mak
  • Patent number: 10905318
    Abstract: An endoscope system includes a processor and displays a distribution image of living substance feature amounts obtained from an imaged image of a living tissue. The processor calculates the living substance feature amount in the living tissue, for example, an amount of hemoglobin and oxygen saturation of the hemoglobin using components of color image data of the living tissue illuminated with at least two lights, generates the feature amount distribution image illustrating a distribution of the living substance feature amounts, and controls display of the feature amount distribution image in order to display the generated feature amount distribution image so as to be superimposed on the image of the living tissue.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: February 2, 2021
    Inventors: Masaaki Fukuda, Yoshimi Obara, Toru Chiba
  • Patent number: 10874496
    Abstract: Implants are provided, comprising the implant and a plurality of sensors. Briefly stated, implants (also sometimes referred to as ‘devices’ or medical devices’) are provided comprising an implant along with one or more sensors to monitor the integrity, position and efficaciousness of the implant. The sensors may be positioned on the inside of the implant, within the body of the implant, or on the outer surface (or surfaces) of the implant, and/or between the implant and any device that might be utilized to deliver the implant (e.g., another implant, catheter, tunneling catheter, endoscope, balloon implant, or other medical device).
    Type: Grant
    Filed: June 25, 2015
    Date of Patent: December 29, 2020
    Assignee: Canary Medical Inc.
    Inventor: William L. Hunter
  • Patent number: 10870828
    Abstract: A cell survival rate determining device includes a survival rate calculation unit calculating the survival rate of cells in a cell population based on a peak wavelength giving a peak intensity of autofluorescence emitted by the cell population and a peak wavelength of excitation light giving the peak intensity of autofluorescence; and a determination unit determining whether the calculated survival rate of cells is reliable or not based on an amount of a shift and a direction of the shift per unit time in the peak wavelength of autofluorescence and an amount of a shift and a direction of the shift per unit time in the peak wavelength of excitation light.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: December 22, 2020
    Inventor: Norio Hasegawa
  • Patent number: 10709505
    Abstract: A medical device may include an ablation device configured to deliver ablation energy to a treatment site. The medical device may further include a probe device configured to deliver excitation radiation to the treatment site. Further the medical device may include a radiation-receiving device configured to receive photoluminescence radiation emitted from the treatment site in response to the treatment site being illuminated by the excitation radiation and to generate a detection signal in response to the received photoluminescence radiation. Additionally, the excitation radiation may be different from the ablation energy.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: July 14, 2020
    Assignee: Boston Scientific Corporation
    Inventors: Ralf Brinkmann, Birgit Lange
  • Patent number: 10694151
    Abstract: An endoscopic video system and method using a camera with a single color image sensor, for example a CCD color image sensor, for fluorescence and color imaging and for simultaneously displaying the images acquired in these imaging modes at video rates in real time is disclosed. The tissue under investigation is illuminated continuously with fluorescence excitation light and is further illuminated periodically using visible light outside of the fluorescence excitation wavelength range. The illumination sources may be conventional lamps using filters and shutters, or may include light-emitting diodes mounted at the distal tip of the endoscope.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: June 23, 2020
    Assignee: Novadaq Technologies ULC
    Inventors: Paul R. Westwick, David Potkins, John Fengler
  • Patent number: 10682198
    Abstract: A surgical site is simultaneously illuminated by less than all the visible color components that make up visible white light, and a fluorescence excitation illumination component by an illuminator in a minimally invasive surgical system. An image capture system acquires an image for each of the visible color components illuminating the surgical site and a fluorescence image, which is excited by the fluorescence excitation component from the illuminator. The minimally invasive surgical system uses the acquired images to generate a background black and white image of the surgical site. The acquired fluorescence image is superimposed on the background black and white image, and is highlighted in a selected color, e.g., green. The background black and white image with the superimposed highlighted fluorescence image is displayed for a user of the system. The highlighted fluorescence image identifies tissue of clinical interest.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: June 16, 2020
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Ian E. McDowall, Christopher J. Hasser
  • Patent number: 10668291
    Abstract: In some examples, a system may be used for delivering cardiac therapy or cardiac sensing. The system may include an in implantable medical device including a housing configured to be implanted on or within a heart of a patient, a fixation element configured to attach the housing to the heart; and a sensor configured to produce a signal that indicates motion of the implantable medical device. Processing circuitry may be configured to identify one or more impingements between the housing and another structure, such as a tissue of the heart, based on the signal from the sensor and provide an indication of the one or more impingements to a user.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: June 2, 2020
    Assignee: Medtronic, Inc.
    Inventors: Berthold Stegemann, Richard Cornelussen, Robert W. Stadler
  • Patent number: 10517674
    Abstract: The invention provides a non-invasive device comprising an optical system having a laser light source for generating a light beam, being configured such that, in use, the light beam exits the device and impinges on an outer surface of the skin to be treated; the optical system being configured to focus, in use, the light beam at a position of a treatment location inside the skin, whereby Laser Induced Optical Breakdown is induced at the position of the treatment location; an opening disposed such that, in use, light returning from the skin enters the device as a measurement light beam; and a first and second intensity detection channel configured and arranged to detect the intensity in, respectively, a first and a second bandwidth range of the measurement light beam, wherein the first and the second bandwidth ranges both comprise a wavelength of light produced in the skin as a result of Laser Induced Optical Breakdown, and the first bandwidth range comprises the Second Harmonic Generation wavelength of the la
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: December 31, 2019
    Inventors: Babu Varghese, Rieko Verhagen
  • Patent number: 10463287
    Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: November 5, 2019
    Assignee: Profusa, Inc.
    Inventors: Natalie A. Wisniewski, Kristen Helton, William A. McMillan
  • Patent number: 10386304
    Abstract: The invention is directed to a light measuring apparatus which is configured to generate broadband light from a laser beam emitted from a light source, the broadband light having a broader band than that of the laser beam, to divide the broadband light into a long wavelength component and a short wavelength component, to perform CARS measurement using the long wavelength component, and to perform fluorescence observation using the short wavelength component.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 20, 2019
    Assignee: Hitachi, Ltd.
    Inventor: Kakuro Hirai
  • Patent number: 10342435
    Abstract: The light irradiation range of a probe for a photoacoustic measurement apparatus is increased. The probe for a photoacoustic measurement apparatus includes a light transmission unit that irradiates a subject with light, and a photoacoustic wave detector 52 that detects a photoacoustic wave generated from the subject. The light transmission unit includes light propagation part 51 for propagating light, and a light transmission member 55. Further, the light transmission member 55 includes an inner peripheral surface 55a that is formed in the shape of a curved concave surface and an outer peripheral surface 55b that has a radius of curvature larger than the radius of curvature of the inner peripheral surface 55a and is formed in the shape of a curved convex surface. The outer peripheral surface 55b is disposed so that the light L emitted from the light propagation part 51 is incident on the inner peripheral surface 55a.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: July 9, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Kaku Irisawa, Takeya Abe
  • Patent number: 10261277
    Abstract: An optical device for illuminating the vasculature of a mammal using ultraviolet, visible, and/or infrared light is described. The optical device includes an optical fiber encased in a biocompatible sheath, and is dimensioned to lie within an intravascular catheter. When placed within a vascular space and coupled with a suitable light source the optical device illuminates the vascular space and its contents. The faces of the optical fiber are configured to optimize the capture of ultraviolet, visible, and/or infrared light from a light source without the use of active optics.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: April 16, 2019
    Assignee: UVLrx Therapeutics, Inc.
    Inventors: Scot Johnson, Michael Harter
  • Patent number: 10231667
    Abstract: The present invention relates to a device (10) and method for non-invasively measuring a hydration state of a living being (62). To improve with respect to the convenience-to-use, the cost-effectiveness and the accuracy of the delivered results, the proposed device comprises a first light source (14) for emitting light of a first wavelength into a tissue portion (12) of the living being (62), polarization means (18) for polarizing at least part of the emitted light prior to an interaction of the emitted light with the tissue portion (12), a first light detector (26) for detecting polarized light of the first wavelength reflected at the tissue portion (12) and processing means (32) configured to derive a tissue hydration parameter from the detected reflected polarized light and to determine a body hydration index based on said tissue hydration parameter.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: March 19, 2019
    Inventors: Denny Mathew, Kiran Hamilton J. Dellimore, Rick Bezemer
  • Patent number: 10098574
    Abstract: A device and system for measuring and/or monitoring an analyte present on the skin is provided. The system includes a skin-mountable device that may be attached to an external skin surface and a reader device. The skin-mountable device includes a substrate, a plurality of micro-needles, and nanosensors encapsulated in the micro-needles. The micro-needles are attached to the substrate such that attachment of the substrate to an external skin surface causes to the micro-needles to penetrate into the skin to contact interstitial fluid. The micro-needles can include a sacrificial agent and are configured to become porous on contact with a solvent, e.g., interstitial fluid, which dissolves at least a portion of the sacrificial agent. The nanosensors encapsulated in the micro-needles include a detectable label and are configured to interact with a target analyte present in the interstitial fluid.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: October 16, 2018
    Assignee: Verily Life Sciences LLC
    Inventor: Kimberly Kam
  • Patent number: 10078897
    Abstract: One aspect of the present disclosure describes a method for burn wound assessment that identifies burn wound conversion. The method includes performing non-contact imaging on the burn wound with an imaging modality configured to record imaging data. The imaging modality includes active dynamic thermography (ADT). Based on the imaging data, an area of the burn wound undergoing conversion can be determined. The determination can be accomplished automatically by a system comprising a processor.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: September 18, 2018
    Assignee: MEDSTAR HEALTH
    Inventors: Jeffrey W. Shupp, Nicholas J. Prindeze, Lauren T. Moffatt
  • Patent number: 10016151
    Abstract: A device for the real-time in vivo detection of a number of conditions within the patient, including CTCs, circulating nucleic acids, other circulating elements, blood pressure, heart rate data, pulse oxygen concentration, serum electrolyte concentrations, blood glucose, and pH, the device having an implanted subcutaneous access port in the chest region and a catheter having a terminus in the superior vena cava, the device having microelectronic circuitry with a rechargeable energy source encased in a titanium shell, an NIR laser sealed in the titanium-enclosed circuitry platform, and NIR-specific optical fibers (nir-FO) for transmitting the NIR photons to the end of the catheter tube in the superior vena cava. Scattered NIR photons are collected through the end of a second nir-FO bundle and transmitted back to the detector and microprocessor on the portal platform.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: July 10, 2018
    Inventors: Michael A. Tangrea, Sean O'Hearn, Mauro Moscucci
  • Patent number: 9918792
    Abstract: A method and system for atrial fibrillation ablations utilizing a fluoroscopy and/or medical image(s) based cardiac mapping system adapted for balloon based catheters including cryoballoon catheter. The method and system incorporates overlaying two or more sets of images on top of each other where the transparency between the images can be adjusted as an aid in the optimal placement of the balloon based catheters. Further, tags and markers are also placed on fluoroscopic and/or other medical images indicative of where the tissue that has been ablated. The method and system also comprises the ability to monitor esophageal temperature, and to activate alarms and/or energy delivery interrupt based on pre-determined esophageal temperature parameters.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: March 20, 2018
    Inventors: Birinder R. Boveja, Angely Widhany
  • Patent number: 9854975
    Abstract: Skin monitoring device for application near the skin includes a processing circuit and at least one photosensor configured to detect at least one approximate wavelength of light reflected and/or emitted by the skin. A signal receiving circuit receives signals from the photosensor.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: January 2, 2018
    Inventors: Liesbeth Van Pieterson, Margreet De Kok, Sima Asvadi, Bernardus Hendrikus Wilhelmus Hendriks, Gerhardus Wilhelmus Lucassen, Jacqueline Van Driel, Paul Van Der Sluis
  • Patent number: 9826894
    Abstract: An endoscope system including a control section that controls an LED driving section to supply driving currents to LEDs of a plurality of colors to cause the LEDs to emit lights in a frame-sequential manner and a processor that divides a total exposure period in one frame period of the frame-sequential light emission into ratios of light emission periods for each of the respective colors obtained by dividing light amount ratios of the lights of the plurality of colors, which should be received in a CCD, respectively by respective maximum light emission intensities of the LEDs of the plurality of colors and sets respective maximum light emission periods of the LEDs of the plurality of colors.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 28, 2017
    Inventors: Takahiro Masaki, Yusuke Yabe, Tomoya Takahashi, Masato Toda, Yutaka Shirota, Daisuke Akiyama, Koji Omori
  • Patent number: 9801549
    Abstract: The invention is directed to an apparatus for finding a functional tissue area in a tissue region. The apparatus has a measurement illuminating device suitable for emitting measurement illumination to the tissue region and a camera which can capture light reflected by the tissue region. The camera has a green channel and/or a blue channel wherein there is a change in an optical property of the light reflected by the tissue region during the stimulation thereof which is undertaken at least intermittently. An evaluation unit captures the change in the optical property only by a signal of the green channel and/or of the blue channel of the camera. A display unit can display an output signal of the evaluation unit for the functional tissue area in the tissue region.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: October 31, 2017
    Assignees: Carl Zeiss Meditec AG, Technische Universitaet Dresden Institut fuer Biomedizinische Technik, Technische Universitaet Dresden Klinik und Poliklinik fuer Neurochirurgie
    Inventors: Gerald Panitz, Christoph Hauger, Marco Wilzbach, Roland Guckler, Tobias Meyer, Martin Oelschlaegel, Ute Morgenstern, Stephan B. Sobottka, Gabriele Schackert
  • Patent number: 9717417
    Abstract: Certain aspects relate to apparatuses and techniques for non-invasive optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications, including assessing the presence and severity of tissue conditions, such as burns and other wounds.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: August 1, 2017
    Assignee: SPECTRAL MD, INC.
    Inventors: John Michael DiMaio, Wensheng Fan, Jeffrey E. Thatcher, Weizhi Li, Weirong Mo
  • Patent number: 9697434
    Abstract: An edge detection method includes reading at least a portion of wide-band pixel signals generated by wide-band pixels of an image sensor. The image sensor also includes narrow-band pixels that generate narrow-band pixel signals that remain unread. The method also includes sending the wide-band pixel signals to an image signal processor, forming a partially-filled reference image based on data from the wide-band pixel signals; and applying an edge-forming technique to the partially-filled reference image to produce an edge map. An edge detection system includes a two-dimensional array of pixels having wide-band pixels and narrow-band pixels, an image signal processor for producing an edge map from a partially-filled reference image, and a readout circuit for generating the partially-filled reference image for the image signal processor. The partially-filled reference is based only on at least part of the wide-band pixels.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: July 4, 2017
    Assignee: OmniVision Technologies, Inc.
    Inventor: Robbert Emery
  • Patent number: 9616248
    Abstract: An integrated radiation therapy process comprises acquiring first objective target data related to a parameter of a target within a patient by periodically locating a marker positioned within the patient using a localization modality. This method continues with obtaining second objective target data related to the parameter of the target by periodically locating the marker. The first objective target data can be acquired in a first area that is apart from a second area which contains a radiation delivery device for producing an ionizing radiation beam for treating the patient. The localization modality can be the same in both the first and second areas. In other embodiments, the first objective target data can be acquired using a first localization modality that uses a first energy type to identify the marker and the second objective target data can be obtained using a second localization modality that uses a second energy.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 11, 2017
    Assignee: Varian Medical Systems, Inc.
    Inventors: Eric Meier, Timothy P. Mate, J. Nelson Wright, Steven C. Dimmer, Lynn M. Purdy
  • Patent number: 9591966
    Abstract: An electronic endoscope system includes a light source that emits light having a visible light wavelength region, and an optical filter that has transmission peaks at least at two particular wavelengths in a continuous wavelength region including the visible light wavelength region. The optical filter has a transmissivity that suppresses a light amount cut by the optical filter between the transmission peaks of the at least two particular wavelengths and has a transmissivity of zero at a wavelength region other than an interval between the transmission peaks of the at least two particular wavelengths. A solid-state image pick-up receives reflected light from an object which is irradiated with illumination light via the optical filter and an image generator is configured to generate a color image to be displayed on a monitor by processing an image signal output by the solid-state image pick-up.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: March 14, 2017
    Inventors: Fumika Yokouchi, Chinari Tanaka
  • Patent number: 9381292
    Abstract: An implantable device that continuously regulates the blood glucose levels of a type 1 diabetes mellitus patient is provided. The device which is implanted in the bloodstream, relies on a microfluidic chip and a microsieve that efficiently separate leukocytes away from an amount of blood received and an islet compartment made up of multiple islets (beta and alpha cells) from at least one compatible donor pancreas source. During hyperglycemia, insulin is produced by the beta cells to remove excessive sugar from the blood. Similarly, during hypoglycemia, glucagon is secreted by the alpha cells to bring the blood glucose level back to normal. The device is self-sustaining without relying on an electrically-powered insulin pump or refills of exogenous insulin.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: July 5, 2016
    Inventor: Kamal Ahmed Aljohani
  • Patent number: 9330440
    Abstract: A medical image processing apparatus may include an image data generator to generate image data corresponding to at least two different energy bands by using an X-ray, an ROI processor to highlight a tissue of interest classified based on a predetermined characteristic to be distinguished from a normal tissue, in the generated image data, and a display to alternately display first image data in which the tissue of interest is not highlighted, and second image data in which the tissue of interest is highlighted to be distinguished from the normal tissue.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: May 3, 2016
    Inventors: Jae Hyun Kwon, Sung Su Kim, Young Hun Sung, Hyun Hwa Oh, Myung Jin Chung
  • Patent number: 9211072
    Abstract: A disposable active pulse sensor has an emitter that generates optical radiation having a plurality of wavelengths, a detector that is responsive to the optical radiation and an unbalanced electrical motor that vibrates when energized. A tape assembly removably attaches the emitter, the detector and the unbalanced electrical motor to a tissue site. The tape assembly also physically mounts the emitter, the detector and the unbalanced electrical motor in a spatial arrangement so that vibration from the unbalanced electrical motor induces pulsatile blood flow within the tissue site, the emitter transmits the optical radiation into the tissue site and the detector generates a sensor signal responsive to the intensity of the optical radiation after attenuation by the pulsatile blood flow within the tissue site.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: December 15, 2015
    Inventor: Massi Joe E. Kiani
  • Patent number: 9204830
    Abstract: A system is provided that furnishes expert procedural guidance based upon patient-specific data gained from surgical instruments incorporating sensors on the instrument's working surface, one or more reference sensors placed about the patient, sensors implanted before, during or after the procedure, the patient's personal medical history, and patient status monitoring equipment. Embodiments include a system having a surgical instrument with a sensor for generating a signal indicative of a property of a subject tissue of the patient, which signal is converted into a current dataset and stored. A processor compares the current dataset with other previously stored datasets, and uses the comparison to assess a physical condition of the subject tissue and/or to guide a procedure being performed on the tissue.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: December 8, 2015
    Inventors: Jason Matthew Zand, Gregory Scott Fischer
  • Patent number: 9165231
    Abstract: Passive RFID devices are disclosed that perform image recognition. The device includes an antenna, circuitry, and a camera. The antenna receives a radio frequency (RF) signal from a RFID reader. The circuitry stores image data for objects that is used for image recognition. To operate, the circuitry derives power from the RF signal. With the power derived from the RF signal, the camera captures an image. The circuitry then identifies an object in the captured image based on the image data for the objects, and outputs information for the identified object, such as to the RFID reader.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: October 20, 2015
    Assignee: Ricoh Company, Ltd.
    Inventors: Jonathan J. Hull, Kathrin Berkner, Sergey Chemishkian, Xu Liu, Sapna A. Shroff
  • Patent number: 9060687
    Abstract: The present invention detects a fluorescent signal from AGEs at a blood vessel tissue of an individual to determine the condition of the tissue of the individual. This solves a problem that in measurement of AGEs used in diagnosis of diabetes, data indicative of fluorescent spectrum from AGEs at the skin of a forearm varies depending on where to measure on skin of even the same forearm, which results in variations in measurement values, leading to unreliable data and incorrect measurement result.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: June 23, 2015
    Inventors: Mikihiro Yamanaka, Megumi Hijikuro, Keita Hara
  • Publication number: 20150148631
    Abstract: 2,5-Bis(benzoxazol-2?-yl)benzene-1,4-diol derivatives (Zinhbo derivatives) are used to detect zinc ions and have particular application in vivo and in vitro. Zinhbo derivatives upon excitation give a florescence response emission that can be used to determine the presence of zinc cation in solution. Zinhbo derivatives complexed with zinc cations upon excitation can produce a florescence response emission in the visible and near infrared range. Zinhbo derivatives complexed with zinc cations exhibit a large stoke shift between the excitation and emission wavelengths.
    Type: Application
    Filed: February 3, 2015
    Publication date: May 28, 2015
    Inventors: Yi Pang, Yongqian Xu
  • Publication number: 20150148629
    Abstract: An optical spectroscopy probe for providing optical spectroscopy guidance of a mechanical biopsy procedure, and a tissue biopsy device including an optical spectroscopy probe. The optical spectroscopy probe is positionable in a lumen of a mechanical biopsy device. The probe may enable optical spectroscopy guidance in biopsy procedures, include brain biopsy procedures.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 28, 2015
    Inventors: Brian C. Wilson, Anthony Taywon Kim, Pablo A. Valdes, Keith D. Paulsen, David W. Roberts