Light Conducting Fiber Inserted In Body Patents (Class 600/342)
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Patent number: 12220205Abstract: Embodiments of the present disclosure include a photodiode that can detect optical radiation at a broad range of wavelengths. The photodiode can be used as a detector of a non-invasive sensor, which can be used for measuring physiological parameters of a monitored patient. The photodiode can be part of an integrated semiconductor structure that generates a detector signal responsive to optical radiation at both visible and infrared wavelengths incident on the photodiode. The photodiode can include a layer that forms part of an external surface of the photodiode, which is disposed to receive the optical radiation incident on the photodiode and pass the optical radiation to one or more other layers of the photodiode.Type: GrantFiled: November 14, 2023Date of Patent: February 11, 2025Assignee: MASIMO SEMICONDUCTOR, INC.Inventors: Steven J. Wojtczuk, Xuebing Zhang, William J. MacNeish, III
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Patent number: 11896373Abstract: A spectroscopic laser sensor based on hybrid lll-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a lll-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGal-nAsSb/GaSb based photodetectors and embedded electronics for signal processing.Type: GrantFiled: May 21, 2018Date of Patent: February 13, 2024Assignee: Brolis Sensor Technology, UABInventors: Augustinas Vizbaras, Kristijonas Vizbaras, Ieva Simonyte, Günther Roelkens
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Patent number: 11850024Abstract: Embodiments of the present disclosure include a photodiode that can detect optical radiation at a broad range of wavelengths. The photodiode can be used as a detector of a non-invasive sensor, which can be used for measuring physiological parameters of a monitored patient. The photodiode can be part of an integrated semiconductor structure that generates a detector signal responsive to optical radiation at both visible and infrared wavelengths incident on the photodiode. The photodiode can include a layer that forms part of an external surface of the photodiode, which is disposed to receive the optical radiation incident on the photodiode and pass the optical radiation to one or more other layers of the photodiode.Type: GrantFiled: August 4, 2021Date of Patent: December 26, 2023Assignee: MASIMO SEMICONDUCTOR, INC.Inventors: Steven J. Wojtczuk, Xuebing Zhang, William J. MacNeish
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Patent number: 11648416Abstract: An optically stimulating module to be integrated into a probe is implantable into a living being with a view to locally illuminating a region of said living being. The module includes a casing, and a hermetic electronic unit housed in the casing. The hermetic electronic unit includes two luminous diodes connected back-to-back, and at least two electrical contacts for connecting the module to an electrical power source.Type: GrantFiled: December 10, 2020Date of Patent: May 16, 2023Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Claude Chabrol
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Patent number: 11596319Abstract: A heart rate module, comprising a housing structure composed of a rear housing (2) and a light-transmitting cover plate (3), the housing structure being internally provided with a PCB assembly (1); the PCB assembly (1) comprises a PCB, PDs (6, 7) and an LED (5), the PDs (6, 7) and the LED (5) being fixed on the PCB according to a preset distance; a hot melt positioning column (21) is provided on the rear housing (2), and the PCB assembly (1) is fixed, by means of the hot melt positioning column (21), on the rear housing (2). Use of the heart rate module can solve the problems of the assembly method of the available heart rate meter being complicated and the requirement for a terminal product being high.Type: GrantFiled: September 6, 2018Date of Patent: March 7, 2023Assignee: WEIFANG GOERTEK MICROELECTRONICS CO., LTD.Inventors: Wentao Wang, Bo Fu, Xinliang Li
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Patent number: 11426180Abstract: A surgical system for penetrating and determining a characteristic of tissue. An instrument generates rotational torque, and a drill bit tool body extends along an axis between a distal end to engage tissue and a proximal end to couple to the instrument. An emitter operatively coupled to the instrument emits light. A detector operatively coupled to the instrument detects light. An emission lightguide within the tool body transmits light emitted by the emitter toward the tissue as the instrument rotates the tool body. A detection lightguide within the tool body is spaced from the emission lightguide and transmit light reflected by the tissue toward the detector as the instrument rotates the tool body. The emitter emits light into the emission lightguide along the axis, and the detector detects light reflected from the tissue exiting the detection lightguide transverse to the axis when the tool body is coupled to the instrument.Type: GrantFiled: August 3, 2018Date of Patent: August 30, 2022Assignee: University College Cork—National University of Ireland CorkInventors: Peter Andrew O'Brien, Matthieu Francois Gabriel Duperron, Ray Burke, Cormac James Eason, Kevin Manley, Gerard Nunan
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Patent number: 11298057Abstract: A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGaInAsSb/GaSb based photodetectors and embedded electronics for signal processing.Type: GrantFiled: July 7, 2021Date of Patent: April 12, 2022Assignees: Brolis Sensor Technology, UAB, Universiteit Gent, IMEC VZWInventors: Augustinas Vizbaras, Kristijonas Vizbaras, Ieva {hacek over (S)}imonytė, Günther Roelkens
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Patent number: 11259793Abstract: A surgical access assembly comprises a trocar and a surgical instrument. The trocar comprises a housing and an access tube extending distally from the housing. The housing comprises a hollow light emitter. The housing and the access tube define a lumen extending through the housing and the access tube. The hollow light emitter is configured to project light in the lumen. The surgical instrument comprises an end effector and a shaft extending proximally from the end effector. The shaft comprises an optical receiver positioned within reach of the light from the hollow light emitter. The shaft further comprises a light guide extending from the optical receiver along at least a portion of the shaft toward the end effector.Type: GrantFiled: September 11, 2018Date of Patent: March 1, 2022Assignee: Cilag GmbH InternationalInventors: Charles J. Scheib, Joshua D. Young
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Patent number: 11213227Abstract: A pulse oximeter includes a curved holder. A flexible substrate is coupled to a curved inner surface of an outer portion of the curved holder. A light emitter, a light receiver, and a reinforcement are coupled to a curved inner surface of the flexible substrate. The reinforcement is curved to extend in conformance with the curved form of the flexible substrate. The material of the reinforcement has a Young's modulus that is larger than the Young's modulus of the material of the outer portion and the Young's modulus of the material of an inner portion.Type: GrantFiled: April 23, 2020Date of Patent: January 4, 2022Assignee: MURATA VIOS, INC.Inventors: Nobuhiro Kondo, Yoshitaka Hane, Kenichi Fukuda, Masamichi Yanai
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Patent number: 11042018Abstract: A microfluidics analysis system with a microfluidics cell and a microscope. The microscope has an objective lens arranged to collect light from a field of view including a portion of the microfluidics cell; a second lens; and an actuator arranged to translate the objective lens relative to the microfluidics cell to change a position of the field of view between multiple positions. The actuator is arranged to translate the objective lens relative to the microfluidics cell without moving the second lens relative to the microfluidics cell. The second lens is arranged to receive the light collected by the objective lens for the multiple positions of the field of view without moving relative to the microfluidics cell.Type: GrantFiled: July 11, 2018Date of Patent: June 22, 2021Inventors: John Charles Clifford Day, Alastair Poole
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Patent number: 11039750Abstract: Needle interventions are widely used in the field of oncology for taking biopsies of tissue in order to inspect whether tissue is cancerous or not. To make these interventions more reliable feedback of what kind of tissue is in front of the needle is required. A way to achieve this is by making use of optical spectroscopy. This requires integration of fibers into the needle. These fibers are used to deliver light to illuminate the tissue in front of the needle and to collect back the reflected light from the tissue. The present invention proposes to integrate the fiber distal ends in the slanted bevel of the needle in such a way that at least one source-detector fiber pair has a distance that is larger than the outer diameter of the needle.Type: GrantFiled: September 12, 2016Date of Patent: June 22, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Bernardus Hendrikus Wilhelmus Hendriks, Augustinus Laurentius Braun, Rik Harbers, Marjolein Van Der Voort, Adrien Desjardins, Rami Nachabe
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Patent number: 10932670Abstract: Optical pressure sensor assemblies that can be used with existing catheters and imaging systems. Pressure sensors may be compatible with atherectomy and occlusion-crossing catheters, where intravascular pressure measurements at various vessel locations are needed to determine treatment efficacy. The pressure sensors may employ an optical pressure measurement mechanism using optical interferometry, and may be integrated with existing imaging modalities such as OCT. The pressure sensor assemblies may include a movable membrane that deflects in response to intravascular pressure; an optical fiber that transmits light to the movable membrane and receives light reflected or scattered back from the movable membrane into the fiber; and a processor or controller configured to determine the distance traveled by the light received in the fiber from the movable membrane, where the distance traveled is proportional to the intravascular pressure exerted against the membrane.Type: GrantFiled: March 15, 2013Date of Patent: March 2, 2021Assignee: Avinger, Inc.Inventors: Peter H. Smith, Manish Kankaria
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Patent number: 10912611Abstract: An aesthetic treatment device uses multiple light sources, lasers or LEDs focused on the treatment area from different directions. The multiple light sources for treatment purposes could have the same wavelength or different wavelengths each optimized for a different application. Target selection is performed by a dual wavelength smart illumination system combined with an imaging system, a smart processor for target recognition and a scanning system that directs the focused light from laser sources to an automatically selected treatment area. A motorized optical system performs a dual role of: focusing the laser sources and also steering the focused light to specific locations as designated by the imaging and processing systems.Type: GrantFiled: February 1, 2016Date of Patent: February 9, 2021Assignee: S & Y ENTERPRISES LLCInventors: Oren Aharon, Yehuda Poran
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Patent number: 10842889Abstract: A contrast composition for photoacoustic imaging includes a photoacoustic contrast agent and a gelling agent.Type: GrantFiled: June 2, 2016Date of Patent: November 24, 2020Assignee: SAMSUNG MEDISON CO., LTD.Inventors: Jin-woo Jung, Deok-woo Choi, Jae-ho Lee, Won-jae Lee, Hyo-keun Lim
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Patent number: 10835127Abstract: An apparatus detects atherosclerotic plaques. The apparatus includes an electronic processing device that determines a level of fluorescence sensed by a sensor at a second infrared wavelength in response to exposure of at least part of an artery to radiation at a first infrared wavelength and determines a fluorescence indicator using the level of fluorescence. The fluorescence indicator is indicative of the presence, absence or degree of an atherosclerotic plaque.Type: GrantFiled: April 12, 2013Date of Patent: November 17, 2020Assignee: BAKER IDI HEART & DIABETES INSTITUTE HOLDINGS LIMITEDInventors: Karlheinz Peter, Nay Min Htun, Yung-Chih Chen
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Patent number: 10695469Abstract: Assemblies, systems, and methods convey fluid from an internal wound site or body cavity by applying negative pressure from a source outside the internal wound site or body cavity through a wound drain assembly that is placed directly inside the internal wound site or body cavity.Type: GrantFiled: October 12, 2017Date of Patent: June 30, 2020Assignee: IC Surgical, Inc.Inventor: Bradley Bengtson
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Patent number: 10646147Abstract: A sensor insertion assembly includes: a sensor insertion device comprising a needle member configured to be inserted in a living body together with a biological information sensor and to be pulled out of the living body after leaving a distal end side of the sensor in the living body; and a base plate detachably attached to a first end side of the sensor insertion device, the base plate comprising a clamp portion configured to move so as to clamp a proximal end side of the sensor extending to an outside of the living body after pulling out the needle member and along with an operation of detaching the sensor insertion device from the base plate.Type: GrantFiled: July 12, 2017Date of Patent: May 12, 2020Assignee: TERUMO KABUSHIKI KAISHAInventors: Takeshi Tsubouchi, Eiji Arita, Hideyuki Momoki
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Patent number: 10617339Abstract: The invention provides an endoscope system for generating an oxygen saturation image that can be used for various medical applications, such as oxygen saturation monitoring during surgery. A clip 141 is attached to the surrounding tissue of a tumor CN from the luminal side. The tissue to which the clip 141 is attached becomes an ischemic part CL. An oxygen saturation image is generated from image information obtained by imaging the tissue on the abdominal cavity side. In the oxygen saturation image, the ischemic part CL is displayed as a low oxygen region. Accordingly, it becomes easy to find the location of the tumor CN even from the abdominal cavity side.Type: GrantFiled: April 28, 2015Date of Patent: April 14, 2020Assignee: FUJIFILM CorporationInventors: Hiroshi Yamaguchi, Yoshinori Morimoto, Takumi Dejima
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Patent number: 10605983Abstract: Disclosed are a collimator for reducing noise of a scanned image and an imaging catheter system comprising the same. The disclosed noise attenuation collimator comprises: a transparent tube having a diameter larger than a cladding diameter of double-clad fiber, wherein a coatingless region of the double-clad fiber is inserted into the transparent tube; and a first resin layer which is applied to an exterior of the transparent tube and has a refractive index lower than the refractive index of the transparent tube.Type: GrantFiled: February 28, 2017Date of Patent: March 31, 2020Assignees: Industry-University Cooperation Foundation Hanyang University, Korea University Research and Business Foundation, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Hong Ki Yoo, Jin Won Kim, Wang Yuhl Oh, Min Woo Lee, Tae Shik Kim
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Patent number: 10591275Abstract: This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers (SOAs) can be configured to maintain a respective polarization state in an optical input signal provided from a light source (e.g., a broadband light source). The different polarization states can be combined by an optical combiner (e.g., a polarization maintaining fiber coupler) and provided to drive a reference arm and a sample arm implemented in an OCT system.Type: GrantFiled: February 1, 2018Date of Patent: March 17, 2020Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Hui Wang, Andrew Rollins, Xiaoyong Fu
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Patent number: 10524707Abstract: In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.Type: GrantFiled: February 2, 2015Date of Patent: January 7, 2020Assignee: The General Hospital CorporationInventors: Zongxi Li, Conor L. Evans, Alexander J. Nichols
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Patent number: 10480924Abstract: This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers (SOAs) can be configured to maintain a respective polarization state in an optical input signal provided from a light source (e.g., a broadband light source). The different polarization states can be combined by an optical combiner (e.g., a polarization maintaining fiber coupler) and provided to drive a reference arm and a sample arm implemented in an OCT system.Type: GrantFiled: February 1, 2018Date of Patent: November 19, 2019Assignee: CASE WESTERN RESERVE UNIVERSITYInventors: Hui Wang, Andrew Rollins, Xiaoyong Fu
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Patent number: 10314736Abstract: A method for treating obstructive sleep apnea is described herein. The method includes the step of providing a tethering device having an elastic filament having a distal end and a proximal end and a flexible memory head mounted to the distal end of the elastic filament. The method further includes the steps of advancing the tethering device through the tongue of a patient so that the flexible memory head of the tethering device is disposed against the back of the tongue and the elastic filament of the tethering device extends through the tongue and securing the proximal end of the elastic filament to the mandible of the patient under tension, whereby to restrain rearward movement of the tongue while the patient is sleeping.Type: GrantFiled: October 16, 2013Date of Patent: June 11, 2019Assignee: Cook Medical Technologies LLCInventor: Peter J. Catalano
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Patent number: 10231698Abstract: Disclosed herein is a system and method for characterizing adventitial tissue. In one aspect, a system and method is disclosed that characterizes tissue types within the adventitial tissue including nerve bundles and blood vessels. In a further aspect, the adventitia is imaged and characterized to provide guidance for crossing lesions within an occluded vessel.Type: GrantFiled: March 13, 2017Date of Patent: March 19, 2019Assignee: VOLCANO CORPORATIONInventor: Anuja Nair
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Patent number: 10175127Abstract: A surgical instrument for applying fasteners includes a drive motor, a replaceable loading unit having an end-effector assembly, and an adapter configured to releasably couple a replaceable loading unit to the drive motor. The adapter includes a strain gauge having a drive circuit coupled thereto. The strain gauge and the drive circuit are configured to directly measure a driving force in the adapter.Type: GrantFiled: March 27, 2015Date of Patent: January 8, 2019Assignee: Covidien LPInventors: Ethan Collins, John Hryb, Anthony Calderoni, John Pantazis
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Patent number: 10064555Abstract: A guide member system includes a guide member, a light source, and a detector. The guide member comprises at least one illumination fiber. The at least one illumination fiber distally transmits the light projected by the light source from the proximal end of the guide member to the distal end of the guide member. The distal end of the guide member is projects the distally transmitted light. The distal end of the guide member receives light projected from the distal end of the guide member and reflected back toward the distal end of the guide member. The at least one illumination fiber proximally transmits the reflected light from the distal end of the guide member to the proximal end of the guide member. The proximal end of the guide member projects the proximally transmitted light toward the detector. The detector detects the proximally transmitted light.Type: GrantFiled: August 12, 2015Date of Patent: September 4, 2018Assignee: Acclarent, Inc.Inventors: Randy J. Kesten, Scott O. Chamness, Thomas R. Jenkins
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Patent number: 9999343Abstract: The invention provides an endoscope system for the early detection of suture failure. Parts of the large intestine separated by the resection of a tumor are sutured by using a suturing member 167. A sutured portion is imaged. An oxygen saturation image 180 is generated by imaging the oxygen saturation of the sutured portion based on image information obtained by the imaging. The generated oxygen saturation image 180 is displayed on a display device 14. In the case of suture failure, a low oxygen region 180a is displayed in the oxygen saturation image.Type: GrantFiled: April 27, 2015Date of Patent: June 19, 2018Assignee: FUJIFILM CorporationInventors: Yoshinori Morimoto, Takumi Dejima, Hiroshi Yamaguchi
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Patent number: 9848764Abstract: A catheter and method for managing fluid in a patient, the catheter having an elongated shaft with a distal end and a proximal end. The shaft defines at least one lumen extending substantially therethrough, the shaft further defining a plurality of drainage holes along a distal portion of the shaft, with the drainage holes in fluid communication with the lumen. The catheter further has a substantially transparent tip portion attached to the distal end of the shaft with an outer distal leading surface that is substantially rounded to assist insertion through tissue.Type: GrantFiled: October 14, 2014Date of Patent: December 26, 2017Assignee: INTEGRA LIFESCIENCES SWITZERLAND SÀRLInventors: Alan J. Dextradeur, Daniel McCusker
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Patent number: 9835812Abstract: A multi-fiber aggregate is provided. The multi-fiber aggregate includes at least two optical fibers, each of the at least two optical fibers having a core member formed from a silica-based glass and an outer cladding layer formed from a silica-based glass surrounding and in direct contact with the core member. The multi-fiber aggregate also includes a polymeric binding coating surrounding the at least two optical fibers and holding the at least two fibers in a predetermined geometry.Type: GrantFiled: August 3, 2016Date of Patent: December 5, 2017Assignee: Corning IncorporatedInventor: Michael John Yadlowsky
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Patent number: 9782109Abstract: A system for measuring the luminance and temperature of a light source element of a spectrophotometric device is provided. The system includes a photodiode, a luminance measuring device, a temperature measuring device, a first switch, and a controller. The photodiode is operable to receive light signals emitted by the light source element and passing through a subject's body tissue. The luminance measuring device is operable to measure luminance of the light signals received by the photodiode. The temperature measuring device is operable to measure the temperature of the photodiode. The first switch is operable to connect the photodiode to the luminance measuring device or the temperature measuring device. The controller is operable to control the connection of the first switch.Type: GrantFiled: July 6, 2012Date of Patent: October 10, 2017Assignee: CAS Medical Systems, Inc.Inventors: William Kosturko, John K. Gamelin
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Patent number: 9733119Abstract: A serialized probe component for an optoacoustic device has a unique identifier associated therewith and includes, in an embodiment, an operative connection between a read-write memory and the optoacoustic device. Software adapted to generate and store logs in a read-write memory is executed on the optoacoustic device and stores logs concerning utilization of the serialized probe component on the read-write memory. A method for logging operational information concerning an optoacoustic device is further disclosed.Type: GrantFiled: March 15, 2013Date of Patent: August 15, 2017Assignee: Seno Medical Instruments, Inc.Inventors: Gregory Schmid, William Ackerman, Bryan Clingman
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Patent number: 9713434Abstract: A heart-rate sensor for detecting artery blood-flow volume per unit length change in a human or animal subject, which comprises an antenna for sensing the instantaneous volume of blood in the artery of the subject, to be measured; a RADAR unit for transmitting microwave signals into a subject's body part or limb representing tissue targets.Type: GrantFiled: February 7, 2013Date of Patent: July 25, 2017Assignee: SENSIFREE LTD.Inventor: Ilan Saul Barak
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Patent number: 9693717Abstract: A method and apparatus for non-invasively determining a blood oxygen saturation level and/or the presence of fecal matter within a subject's lower GI tissue is provided. The method includes the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) sensing the subject's lower GI Tissue Using the Sensor, and Producing signal data from sensing the subject's tissue; c) processing the signal data, including determining the presence of one or more wavelength dependent light absorbing materials not present within blood within the subject's lower GI tract from the signal data; and d) determining the blood oxygen saturation level and/or presence of fecal matter within the subject's lower GI tissue, including accounting for the presence of the wavelength dependent light absorbing material not present within blood within the subject's lower GI tract determined using the signal data.Type: GrantFiled: July 12, 2010Date of Patent: July 4, 2017Assignee: CAS Medical Systems, Inc.Inventors: Paul B. Benni, Robert J. Kopotic
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Patent number: 9693697Abstract: A method, a computer readable media and a hand-held device, the hand-held device may include a first sensor that is positioned such as to be contacted by a first hand of a user when the user holds the hand-held device; a second sensor that is positioned such as to be contacted by a second hand of the user when the user holds the hand-held device; wherein at least one sensor of the first sensor and the second sensor is a hybrid sensor that comprises an electrode, an illumination element and a light detector; and a health monitoring module arranged to process detections signals from the electrode and from the light detector such as to provide processed signals that are indicative of a state of the user.Type: GrantFiled: March 29, 2012Date of Patent: July 4, 2017Inventors: Benny Tal, Yair Tal, Assaf Pressman
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Patent number: 9636107Abstract: Methods and devices provide constriction of a heart valve annulus to treat cardiac valve regurgitation and other conditions. Embodiments typically include a device for attaching a cinching or tightening apparatus to a heart valve annulus to reduce the circumference of the annulus, thus reducing valve regurgitation. Tightening devices may include multiple tethered clips, multiple untethered crimping clips, stabilizing devices, visualization devices, and the like. In one embodiment, a plurality of tethered clips is secured circumferentially to a valve annulus, and the tether coupling the clips is cinched to reduce the circumference of at least a portion of the annulus. Methods and devices may be used in open heart surgical procedures, minimally invasive procedures, catheter-based procedures, and/or procedures on beating hearts or stopped hearts.Type: GrantFiled: January 5, 2015Date of Patent: May 2, 2017Assignee: Ancora Heart, Inc.Inventors: Rodolfo A. Morales, Niel F. Starksen
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Patent number: 9615748Abstract: Exemplary embodiments of apparatus, method and system for determining a position on or in a biological tissue can be provided. For example, using such exemplary embodiment, it is possible to control the focus of an optical imaging probe. In another exemplary embodiment, it is possible to implement a marking apparatus together with or into an optical imaging probe. According to one exemplary embodiment, it is possible (using one or more arrangements) to receive information associated with at least one image of at least one portion of the biological tissue obtained using an optical imaging technique. Further, it is possible to, based on the information, cause a visible change on or in at least location of the portion(s) using at least one electro-magnetic radiation.Type: GrantFiled: January 20, 2010Date of Patent: April 11, 2017Assignee: The General Hospital CorporationInventors: Guillermo J. Tearney, Brett E. Bouma, Dongkyun Kang, Melissa J. Suter
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Patent number: 9612654Abstract: A method of controlling an influence on a user in a rendering environment includes obtaining signal data representing one or more physiological conditions of a user in response to an influence caused by system feedback of the rendering environment; obtaining data corresponding to a user's desired emotional state, which data is based on the user's self-reports and data representative of accompanying signal data representing one or more physiological conditions of the user over a last period before the accompanying self-report; determining whether the desired emotional state is reached; and if the state is not reached, adapting the system feedback provided by the rendering environment correspondingly.Type: GrantFiled: October 19, 2009Date of Patent: April 4, 2017Assignee: Koninklijke Philips N.V.Inventors: Dirk Brokken, Tim Johannes Willem Tijs, Joris Hendrik Janssen
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Patent number: 9597026Abstract: Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.Type: GrantFiled: November 11, 2014Date of Patent: March 21, 2017Assignee: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
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Patent number: 9592027Abstract: Disclosed herein is a system and method for characterizing adventitial tissue. In one aspect, a system and method is disclosed that characterizes tissue types within the adventitial tissue including nerve bundles and blood vessels. In a further aspect, the adventitia is imaged and characterized to provide guidance for crossing lesions within an occluded vessel.Type: GrantFiled: March 14, 2014Date of Patent: March 14, 2017Assignee: Volcano CorporationInventor: Anuja Nair
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Patent number: 9526426Abstract: A tissue composition monitoring apparatus that includes a catheter with an optical sensor for tissue composition monitoring and ablation lesion determination via an automated algorithm incorporating Arrhenius model thermal denaturation kinetics for determining the characteristics of tissue for example the transmurality of the ablation lesion.Type: GrantFiled: July 18, 2013Date of Patent: December 27, 2016Inventor: Bernard Boon Chye Lim
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Patent number: 9504392Abstract: An apparatus, control system and methods are disclosed for directly measuring a blood pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors arranged along a length of the distal end portion, for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors, and optionally, a temperature and/or flow sensor, are incorporated into a distal end portion having a diameter of 0.89 mm or less, and preferably 0.46 mm or less. Beneficially, all sensors are optically coupled, via respective optical fibers, to an optical coupler at the proximal end of the multi-sensor apparatus, without requiring electrical connections.Type: GrantFiled: October 5, 2015Date of Patent: November 29, 2016Assignee: Three Rivers Cardiovascular Systems Inc.Inventors: Eric Caron, Luc Bilodeau, Michael Paquette
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Patent number: 9492090Abstract: The present application concerns detecting catheter proximity to a blood-vessel wall and blood-vessel wall artifacts associated therewith. In one embodiment, a light source, in a catheter, can be used to project light into the blood vessel. An intensity associated with at least one light wavelength that interacted with blood can be measured. Based on the measured intensity, a determination can be made regarding blood-vessel wall artifacts due to the catheter tip proximity to a blood-vessel wall. Feedback can be provided to the clinician in order to assist the clinician in adjusting the catheter to optimize signal quality and minimize artifacts due to the blood-vessel wall.Type: GrantFiled: October 5, 2011Date of Patent: November 15, 2016Assignee: Edwards Lifesciences CorporationInventors: Zhongping Jian, Clayton M. Young, Feras Hatib
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Patent number: 9452277Abstract: An extension member is has a body with a proximal end and an opposing distal end. It includes a hollow lumen extending therethrough from the proximal end to the distal end. It has a female luer lock connector proximate its proximal end and a male luer lock connector proximate its distal end. Its body has an outer surface with a driven member.Type: GrantFiled: September 6, 2013Date of Patent: September 27, 2016Assignee: CORINDUS, INC.Inventor: Steven J. Blacker
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Patent number: 9445766Abstract: The present invention relates to methods for differentiating a blood vessel from a nonvascular tissue during a minimally invasive surgery using a device. A device may be any penetration sensor device, such as a dilator sensor device, a hollow needle sensor device, or a trocar sensor device, which penetrates the skin and subcutaneous layers to reach a target location inside the body. The penetration sensor device includes a sensor probe which can make optical measurements to determine various parameters of the tissue at the tip of the sensor probe. These parameters may include an optical signal level returned from tissue contacting the tip of the sensor probe, an oxygen saturation level of the tissue, a total hemoglobin concentration, a blood flow, and a pulse. Based on these parameters, the presence or absence of a blood vessel at the tip of the penetration sensor device can be determined while the device travels towards the target location for surgery.Type: GrantFiled: September 28, 2009Date of Patent: September 20, 2016Assignee: ViOptix, Inc.Inventors: Robert E. Lash, Jimmy Jian-min Mao
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Patent number: 9259486Abstract: This method is designed for calculating a quantification indicator for quantifying a dermal reaction on a skin having several chromophores. The method includes illumination of a zone to be characterized on the skin, the skin reaction being included in the zone to be characterized; and measurement of the spectrum of a back scattered radiation coming from the skin after illumination of said zone to be characterized. The method also includes determination, according to the measured spectrum, of an absorption coefficient value for the zone to be characterized, and calculation, according to the absorption coefficient value, of each chromophore concentration. The method includes calculation of the quantification indicator according to each calculated chromophore concentration. The method includes determination, according to the measured spectrum, of a diffusion coefficient value of the zone to be characterized, and the quantification indicator is further calculated according to the diffusion coefficient value.Type: GrantFiled: January 31, 2014Date of Patent: February 16, 2016Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Anne Koenig
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Patent number: 9207176Abstract: A method of measuring the concentration of a substance, using a sensor (2) comprising a luminescent material, an LED light source (14) which supplies a pulse of light to the sensor to cause luminescence of the material, a detector (26) for detecting the emitted light and a data processing module (28) for analysing the signals and indicating the concentration of the substance. In a measuring sequence there is a series of pulses of light spaced apart sufficiently to permit the luminescence to decay between pulses. The signals which are analysed are those generated after each pulse of light has terminated and the luminescence is decaying. The data processing module (28) comprises a plurality of accumulators (52A, 52B, 52C and 52D) which are controlled to be operable over a corresponding plurality of different periods of time during decay of the luminescence. Each accumulator accumulates values indicative of the intensity of the luminescence from the series of pulses in the measuring sequence.Type: GrantFiled: July 19, 2011Date of Patent: December 8, 2015Assignee: Oxford Optronix LTD.Inventor: Geoffrey Ward
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Publication number: 20150141764Abstract: A distributed sensor and a method for identifying an internal anatomical landmark (R) includes inserting (502) a distributed sensing device (212) into a volume of a body and extending (504) a portion of a length of the distributed sensing device beyond an area of interest. Parameters are measured (506) using sensors (202) located along the length of the distributed sensing device (212), and a transition region is determined (510) based upon a parameter value difference between adjacent sensors. A location of an anatomical landmark is assigned (512) using the transition region.Type: ApplicationFiled: May 28, 2013Publication date: May 21, 2015Inventors: Godefridus Antonius Harks, Martinus Bernardus Van Der Mark, Gert Wim 'T Hooft
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Patent number: 9037209Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.Type: GrantFiled: December 6, 2012Date of Patent: May 19, 2015Assignees: SANOFI, CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Axel Scherer, Remi Brouard, III, Emil P. Kartalov, Jingqing Huang
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Publication number: 20150133757Abstract: Novel methods and devices including modified endoscopes that employ fiber optic technology and multiple extrinsic optical sensors for enablement of simultaneous determination of change rates of biological analytes in vivo with single-cell resolution. The devices employ dynamic oscillatory actuation to determine the gradient of analytes of interest along one or multiple directions with respect to the cell. The change rate or flux of the analyte of interest can be easily determined by applying the first Fick's law that relates the flux with the concentration gradient. The dual operation mode of the device markedly increases measurement sensitivity and accuracy.Type: ApplicationFiled: November 11, 2014Publication date: May 14, 2015Applicant: Arizona Board of Regents on behalf of Arizona State UniversityInventors: Deirdre Meldrum, Laimonas Kelbauskas, Jeff Houkal, Roger Johnson, Yanqing Tian, Cody Youngbull
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Publication number: 20150011853Abstract: The invention relates to a measuring device and to a method for measuring parameters of a body tissue using an elongate probe (1) for insertion into the body tissue, comprising at least one optical waveguide (2) for transmitting light beams that runs along the longitudinal axis of the probe within the probe, an exit region (5) from which light beams emitted from the optical waveguide exit into the body tissue, and at least one receiving region (6) through which light beams reflected and/or scattered in the body tissue enter the probe as input light beams on a photodetector or in an optical waveguide (2; 3). The exit region (5) is provided at the distal end of the probe (1) and is oriented at least partially in the longitudinal direction of the probe (1). At least some of the emitted light beams exit the probe in the longitudinal direction of the probe. The at least one receiving region (6) is located at a distance from the distal end of the probe on a lateral circumferential region of the probe.Type: ApplicationFiled: February 17, 2012Publication date: January 8, 2015Applicant: NEMODEVICES AGInventors: Jürg Hans Fröhlich, Markus Hugo Muser