Abstract: This invention provides a system and method to protect an artificial pancreas' sensor, infusion system, and alert systems from EMI/wireless attacks using a medical software or application, close the gap between sensor glucose and blood glucose, and build a non-invasive hypoglycemia and hyperglycemia false alarm detection scheme with the help of a wristband. This inventive method and system provides a more accurate blood glucose prediction. It comprises preprocessing the CGM readings with Kalman smoothing for sensor error correction improves the robustness of the BG prediction. In one or more embodiments, the inventive system and method uses one or more physiological information such as meal, insulin, aggregations of step count, and preprocessed CGM data. The invention provides a novel approach for leveraging the stacked LSTM based deep RNN model to improve the BG prediction accuracy. The invention provides a special circuits-Transduction Shield- to detect and correct the sensor errors caused by EMI attacks.

Abstract: The present disclosure relates to a method of displaying biological information. More specifically, the method allows sequential biological information to be easily displayed and checked using a small area by having the biological information sequentially displayed while rotating over a passage of time corresponding to measurement times of the biological information, and furthermore, by having biological information measured at a most recent measurement time displayed at a reference line, or by allowing biological information at a desired measurement time to be moved to the reference line by a clockwise or counterclockwise rotation, or by having measurement times displayed in a radial fashion in a single circle for each unit period so as to enable a user to select a desired unit period in a left direction or a right direction, the method allows for a user to easily change and check the biological information at the desired measurement time or unit period.

Abstract: A device, system and method is provided for predicting risk of hypoglycemia and adjusting an insulin medicament dose size for a subject being on pen based multi-daily injections. A first algorithm is provided for computing a first insulin dose size based on a plurality of timestamped blood glucose (BG) measurements and insulin injected dose sizes. A risk prediction module is adapted to, based on machine learning algorithms, predict risk of hypoglycemia based on the timestamped BG measurements and calculate a second insulin dose size resulting in a non-hypoglycemic state. In case the second dose size is lower than the first dose size, the first dose size is automatically adjusted down to the second dose size and communicated as the recommended dose size to the subject.

Abstract: The present disclosure relates to a continuous glucose monitoring device, in which a body attachment unit is manufactured so as to be assembled in an applicator, thereby minimizing additional work for a user in attaching the body attachment unit to a body, and allowing attachment of the body attachment unit to the body simply by operation of the applicator. In particular, a wireless communication chip is provided in the body attachment unit to enable communication with an external terminal, thereby enabling simple and convenient use without additional work of connecting a separate transmitter, and allowing easier maintenance. In addition, the continuous glucose monitoring device is activated by a user's operation after the body attachment unit is attached to the body, such that an activation start time can be adjusted to a time appropriate to the user's needs, and the continuous glucose monitoring device can be activated in a stabilized state, and thereby can monitor blood glucose more accurately.

Abstract: A surgical visualization system may include particle trend analysis. The surgical visualization system may include a field programmable gate array (FPGA) that is configured to transform sensor information of backscattered laser light into real-time information of particle movement (e.g., blood cells) in a portion of a surgical field. The system may communicate the real-time information to a processor that is remote to the FPGA for aggregation and analysis. The surgical visualization system may display both a metric representing a present state of moving particles and an aggregated state of the moving particles. The system may display both the rate of particle movement and the acceleration for use by the surgeon.

Abstract: Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score.

Abstract: An analyte monitoring system may include one or more of an analyte sensor, a transceiver, a display device, and a management system. The transceiver may be configured to receive sensor data from the analyte sensor and calculate analyte monitoring information. The display device may be configured to receive the analyte monitoring information from the transceiver. The management system may be configured to receive analyte monitoring information from the display device. The management system may be configured to use the analyte monitoring information to produce a comparison result. The management system may be configured to, based on the comparison result, transmit to the display device management information associated with the received analyte monitoring information. Producing the comparison result may include comparing one or more performance diagnostics with one or more performance indicators. Producing the comparison result may include comparing compliance information with usage protocol information.

Abstract: A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement.

Abstract: An electronic apparatus and a method of controlling the same are provided. The electronic apparatus includes a camera configured to capture an image, a communication interface, a memory configured to store at least one instruction, and a processor configured to obtain characteristics information of a user based on the image; based on the characteristics information of the user being obtained, identify whether first information corresponding to the characteristics information is stored in the memory; based on the corresponding first information not being stored in the memory, generate identification information corresponding to the characteristics information of the user, perform mapping of the characteristics information and the identification information of the user and store in the memory; and transmit the characteristics information and the identification information of the user to a second electronic apparatus.

Abstract: A system and method to provide guidance for diabetes therapy includes determining glycemic risks based on an analysis of glucose data. The analysis includes visualization of a glucose median, the variability of glucose in a patient, and the risk of hypoglycemia. An Advanced Daily Patterns report includes a visualization of an ambulatory glucose profile and a glucose control measure. The glucose control measure provides a highly visible and understandable display of the glucose condition of a patient visually expressed in the categories of low glucose, median glucose, and glucose variability.

Abstract: In one aspect, the invention provides a protein capture membrane comprising a first side and a second side and a plurality of interstices extending contiguously from the first side to the second side, wherein the interstices are coated with a protein-reactive coating; and the porous substrate comprises nanoporous alumina or porous glass. In another aspect the invention provides a method of detecting a protein of interest in a plurality of proteins.

Abstract: Systems and methods are described herein for utilizing a photoacoustic sensor for estimating analyte concentration levels. Also described here are training methods for training an analyte sensor to more accurately estimate an analyte concentration level on the basis of a received acoustic signal.

Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

Abstract: Disclosed herein are techniques related to personalized event detection. In some embodiments, the techniques may involve obtaining a plurality of glucose measurements indicative of a glucose level in a body of a patient during an analysis interval, obtaining a patient-specific meal detection model that identifies one or more glucose measurement statistics that are correlative to occurrence of a meal for the patient, determining values for the one or more glucose measurement statistics based on the plurality of glucose measurements, determining a meal consumption metric based on the values for the one or more glucose measurement statistics, detecting an occurrence of the meal during the analysis interval based on the meal consumption metric, and in response to detecting the occurrence of the meal, providing an indication of the occurrence of the meal during with the analysis interval.

Abstract: Techniques disclosed herein relate to glucose management recommendations based on nutritional information. In some embodiments, the techniques may involve obtaining user input that includes textual input indicating quantitative information for a food item. The techniques may also involve determining, based on the quantitative information for the food item, nutritional information for the food item, where the quantitative information for the food item is different from the nutritional information for the food item. The techniques may further involve generating, based on the nutritional information, a glucose management recommendation.

Abstract: A carrying case for an add-on device of a medicament delivery device is presented where the carrying case has an add-on device holder configured to hold the add-on device, an energy storage device, and a charging device configured to wirelessly electrically charge the add-on device from the energy storage device when the add-on device is held by the add-on device holder.

Abstract: Systems, methods, and devices of a health device network may include: a non-invasive glucometer that non-invasively measures analyte levels; an invasive glucometer communicatively coupled directly to the non-invasive glucometer; a cloud-based server communicatively coupled to the non-invasive glucometer or the invasive glucometer; a user device communicatively coupled to the cloud-based server; and/or a user interface that displays the invasive glucose measurement, the non-invasive glucose measurement, a data batch, and/or processed data to the user. The non-invasive glucometer and/or the invasive glucometer may aggregate an invasive glucose measurement and a non-invasive glucose measurement into the data batch.

Abstract: A method for providing notification regarding one or more analytes includes detecting an amount of each of the one or more analytes using a non-invasive sensor, determining a notification to present based on the amount of at least one of the one or more analytes and notification criteria using a processor, and sending an instruction directing presentation of the notification. The method can further include presenting the notification. The notification can include vibration, sound, or visible components such as light, text, or images. The notification criteria can include upper thresholds, lower thresholds, or the analyte being within or outside of bounded ranges. Systems performing the method can include the sensor and optionally one or more of a mobile device and a remote server, and the notification can be presented in a device including the sensor or a separate device such as the mobile device.

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods.

Abstract: A regression planning and evaluation system that, when operated, obtains audit evidence, for example from manufacturing facility. The system comprises a server arrangement configured to (a) obtain input data, input data comprising data values of variables for multiple samples; (b) validate input data; (c) provide user with user interface to input audit parameters, audit parameters comprising at least one of: assurance level, tolerable error, statistical sampling technique; (d) generate regression plot and identify upper and lower acceptance bounds indicated with respect to regression line, regression plot represents variation of target variable with explanatory variable for samples and (e) identify key items to be tested, key items being samples falling outside the aforesaid acceptance bounds. Audit evidence, for example, can initiate further input data collection, further testing and so forth for reducing errors or distortions present in input data that was earlier acquired for analysis by system.

Abstract: Techniques disclosed herein relate generally to notification generation in a medical device system. In some embodiments, the techniques involve generating a first notification via a medical application executing on a first device, determining that the first notification was not acknowledged within a predetermined time frame, and causing generation of a second notification at a medical device carried by a user to notify the user that the first notification has not been acknowledged.

Abstract: An apparatus includes an input unit, a processing unit, and an output unit. The input unit is configured to provide the processing unit with sensor data for an item of equipment. The processing unit is configured to implement at least one machine learning algorithm, which has been trained on the basis of a plurality of calibration sensor data for the item of equipment. Training of the at least one machine learning algorithm includes processing the plurality of calibration sensor data to determine at least two clusters representative of different equipment states. The processing unit is configured to implement the at least one machine learning algorithm to process the sensor data to assign the sensor data to a cluster of the at least two clusters to determine an equipment state for the item of equipment. The output unit is configured to output the equipment state for the item of equipment.

Abstract: An automated system for controlling a patient's blood glucose, including a blood glucose sensor and a processing and control unit, wherein the processing and control unit is configured to calculate, from a first mathematical model fCR specific to the patient and taking into account a single blood glucose value Gr measured by the sensor, a factor CR representative of the patient's insulin sensitivity.

Abstract: A method for managing glucose levels of a patient under the supervision of a healthcare professional (HCP). The method includes obtaining patient information for the patient, the patient information comprising patient medication data, patient monitoring data, and patient characteristic data. The method also includes creating a patient risk profile based on the patient information. The method also includes determining a likelihood that the patient will experience hyperglycemic effects based on the patient risk profile. The method also includes determining an optimum treatment plan for the patient based on the patient risk profile and the likelihood that the patient will experience hyperglycemic effects. The method also includes executing the optimum treatment plan.

Abstract: A wearable consumer electronic product includes at least a housing arranged to carry operational components comprising a processor and a band having a pliable band body and a securing means arranged to secure the band body to the housing. In one embodiment, the pliable band body has a size and shape suitable for wrapping around an individual appendage and that includes an opening that leads to a cavity within the band body suitable for accumulating an amount of water and a band sensor embedded within the band body in communication with the cavity.

Abstract: Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency.

Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.

Abstract: A method may include displaying at least three icons on a user interface of a mobile device, including a first icon associated with the at least three icons associated with a first carbohydrate level, a second icon associated with the at least three icons associated with a second carbohydrate level, and a third icon associated with the at least three icons associated with a third carbohydrate level. The method may also include receiving a user selection of one of the three icons through the user interface of the mobile device, and determining an insulin bolus level from the user selection. The method may also include communicating the insulin bolus level to an insulin delivery device.

Abstract: A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors.

Abstract: The present invention provides a micro biosensor for reducing a measurement interference when measuring a target analyte in the biofluid, including: a substrate; a first working electrode configured on the surface, and including a first sensing section; a second working electrode configured on the surface, and including a second sensing section which is configured adjacent to at least one side of the first sensing section; and a chemical reagent covered on at least a portion of the first sensing section for reacting with the target analyte to produce a resultant. When the first working electrode is driven by a first working voltage, the first sensing section measures a physiological signal with respect to the target analyte. When the second working electrode is driven by a second working voltage, the second conductive material can directly consume the interferant so as to continuously reduce the measurement inference of the physiological signal.

Abstract: An electromagnetic (EM)-based diagnostics and monitoring system and method for the non-Invasive diagnosis and monitoring of in-vivo and ex-vivo Skin Anomalies Using Lesion-Optimized Sensor System Design and Topology is disclosed herein.

Abstract: An estimating device includes processing circuitry configured to estimate a median of intervals between adjacent data pieces in input time-series data as a uniform interval for the time-series data, and extract data pieces at the estimated uniform intervals from the input time-series data.

Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.

Abstract: A biosensor apparatus comprises a biosensor device and a cover that is configured to attach to the biosensor device. The biosensor device includes a surface section that is disposed above the user's skin and an implantable section that is injected into the user's skin. The implantable section includes a bending detector and sensing circuitry. The sensing circuitry includes one or multiples of a biomarker sensor array, a control biomarker sensor array, a temperature sensor, and/or a biofouling detector.

Abstract: A system for testing properties of a sample, the system including a test cell. The test cell includes a cell casing having a first end piece, a second end piece, and at least one wall extending between the first end piece and the second end piece. The cell casing defines a pressure boundary enclosing an interior region of the cell. The test cell further includes a sample chamber, a first reservoir, and a second reservoir disposed within the pressure boundary. The sample chamber defines an interior region. The first reservoir fluidly connects to the interior region of the sample chamber. The second reservoir fluidly connects to the interior region of the sample chamber. The test cell also has a piston assembly having a piston fluid chamber and a piston with a stem extending into the piston fluid chamber. The piston partially defines the sample chamber.

Abstract: In diabetes management applications, recent glucose measurement values may be clinically useful for acute diagnosis and for the calculation of a corrective therapy. However, the physiological significance of these measurements can lessen with time, which can lead to their becoming less relevant for calculating an effective therapy. A technique is presented for emphasizing analyte values in a diabetes management application during a therapeutic window. In this way, a user is notified that the glucose measurement value is the most current measurement and remains usable for therapy applications, such as an insulin bolus calculation.

Abstract: A system, apparatus, and device estimate the state of the glucose metabolism of the subject based on a correlation between a blood glucose level of the subject acquired in advance and an index which is based on the pulse wave of the subject associated with the blood glucose level.

Abstract: An intraocular pressure (IOP) sensing system may comprise an intraocular pressure sensing implant to be implanted into the eye of a patient for capturing absolute intraocular pressure measurements and an external device for capturing atmospheric pressure measurements. The intraocular pressure sensing implant may be configured to capture an absolute intraocular pressure measurement at an appointed time, and the external device may be configured to capture a plurality of atmospheric pressure measurements around the appointed time.

Abstract: A data management unit for supporting health control, the unit including: a processor, a data input adapted to input data and/or requests and connected to the processor, a data storage connected to the processor, wherein the processor is adapted to assign a tag referring to an event chosen from a group of tags comprising the fasting tag and at least one other event tag to a new data received from the data input or a measurement unit, wherein the tag is assigned either automatically by the processor and/or via the data input, wherein the fasting tag can only be assigned to the new data if a time stamp of the new data is within a predefined fasting window, wherein the predefined fasting window is stored in the data storage.

Abstract: Circuitry for measuring a characteristic of an electrochemical cell, the circuitry comprising: a comparator having a first comparator input, a second comparator input and a comparator output; a feedback path between the comparator output and the second comparator input configured to provide a feedback signal to the second comparator input; and a loop filter configured to apply filtering to the feedback path to generate the feedback signal, wherein the loop filter comprises the electrochemical cell.

Abstract: A method of automatically initializing an analyte sensor for a user is disclosed here. A first analyte sensor is operated in a first measurement mode to generate first sensor signals indicative of an analyte level of the user. A second analyte sensor is deployed to measure the analyte level of the user, and is operated in an initialization mode, concurrently with operation of the first analyte sensor in the first measurement mode, to receive sensor configuration data generated by the first analyte sensor. During operation of the second analyte sensor in the initialization mode, the second analyte sensor is calibrated with at least some of the received sensor configuration data. After the calibrating, operation of the second analyte sensor is transitioned from the initialization mode to a second measurement mode during which the second analyte sensor generates second sensor signals indicative of the analyte level of the user.

Abstract: Disclosed herein are systems and methods for device authentication or pairing. In an aspect, a wearable display system comprises a display, an image capture device configured to capture images of a companion device, a computer-readable storage medium configured to store the images of the companion device, and a processor in communication with the image capture device and the storage medium. The processor can be programmed with executable instructions to receive a first image of a first optical pattern displayed by the companion device captured by the image capture device, wherein the first optical pattern is generated by the companion device based on first shared data, extract first data from the first optical pattern in the received first image, authenticate the companion device based on the first data extracted from the first optical pattern, and notify a user of the wearable display system that the companion device is authenticated.

Abstract: A portable therapeutic platform for use in a therapeutic procedure including: (a) at least one compartment for holding at least one therapeutically effective item required to conduct the therapeutic procedure; and (b) at least one electronic communications device for receiving and transmitting information about an environment surrounding and including the platform. The use of the platform is conveniently managed by a system which transfers information about the environment surrounding and including the platform between the electronic communications device and a computer system including a processor which processes the information; and initiates a control response to the processed information. The platform and system are suitable for use to address a range of public health issues and as a countermeasure to biosecurity threats.

Abstract: Adaptive on board estimation of exogenous pharmacon responsive to transient (i.e., impermanent) physiological effects is provided. Dynamically estimating an equivalent amount of an exogenous pharmacon on board (XOB), such as insulin and/or carbohydrates, left in the subject, is based on predictions of glucose time-series data. These estimated values, such as insulin on board (IOB), are useful for diabetes management software, including decision support and/or artificial pancreas (AP) algorithms, for example.

Abstract: One or more embodiments of the present disclosure may include an insulin delivery system that includes an insulin delivery device, a user interface that includes multiple user-selectable icons or buttons each representing different meal characteristics, memory to store one or more user-specific dosage parameter, and a processor in communication with the memory and adapted to receive blood glucose data. The processor may also be adapted to determine initial meal characteristics associated with each of the user-selectable icons or buttons based on at least one of the user-specific dosage parameters. The processor may also be adapted to update the meal characteristics associated with each of the user-selectable icons or buttons based upon the blood glucose data.

Abstract: Systems, methods and computer-readable media are provided for predicting candidacy for Kidney Surgery and related computer-performed decision support. In particular, embodiments of the disclosure are directed to identifying populations of patients who are candidates for vascular access placement in Chronic Kidney Disease (CKD). Some embodiments of the present disclosure provide a system and method for continually tracking the clinical and physiologic status of a patient in a hospital. At least some of the embodiments assist nephrologists in preventing and reducing the frequency of crises in urgent/emergent presentation with requirement for dialysis (“crashing onto dialysis”) by using the systems' capability to recognize patterns in a patient's eGFR and serum uric acid values before the patient deteriorates or reaches a crisis.

Abstract: Systems and methods are provided for identifying therapeutic zones where there is glycemic dysfunction of a specific type that can be addressed by making strategic changes to behavior and/or therapy parameters. Systems and methods described herein evaluate large historical data sets to: identify a therapeutic zone or zones with glycemic dysfunction that are most readily addressable; quantify the glycemic impact of a plurality of different therapeutic adjustments in terms of either adjustments to historical doses or the parameters of a prospective dosing strategy to determine the highest possible improvement; and/or identify patient dosing strategies to provide therapy recommendations adapted for the patient's preferred behavioral dosing strategy.

Abstract: A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. Each blood glucose measurement is separated by a time interval and includes a blood glucose time associated with a time of measuring the blood glucose measurement. The method also includes receiving patient information at the data processing device and selecting a subcutaneous insulin treatment for tube-fed patients from a collection of subcutaneous insulin treatments. The selection is based on the blood glucose measurements and the patient information. The subcutaneous insulin treatment program for tube-fed patients determines recommended insulin doses based on the blood glucose times. The method also includes executing, using the data processing device, the selected subcutaneous insulin treatment.

Abstract: Systems and methods for testing visible chemical reactions of a reagent are provided. In one implementation, the method may include receiving from an image sensor associated with a mobile communications device an image of a reagent with a plurality of colored test reagent pads in proximity to a colorized surface having a plurality of colored reference elements of differing shades. The method further includes using the differing shades of the plurality of colored reference elements to determine local illumination conditions. Thereafter, the method includes using the determined local illumination conditions and an analysis of a depiction of the plurality of colored test reagent pads in the image to determine an extent of a chemical reaction on the reagent. Then the method includes causing the mobile communications device to provide to the user an indication that the testing of the reagent is complete.

Abstract: A measuring apparatus for determining at least one measurand of a measuring medium includes a first measuring device including a first measuring sensor structured to contact the measuring medium and configured to detect measured values of the at least one measurand, the first measuring device embodied to determine a first measured value that is dependent on the at least one measurand of the measuring medium, a sampling device structured to remove a sample from the measuring medium, a second measuring device including a second measuring sensor and embodied to determine a second measured value that is dependent on the least one measurand of the sample, and an electronic control apparatus configured to receive and process the first and second measured value and to perform a verification, calibration and/or adjustment of the first measuring device using the second measured value.