Simulation Of Modeling Patents (Class 600/416)
  • Patent number: 10872698
    Abstract: A method and system for simulating blood flow in a vessel of a patient to estimate hemodynamic quantities of interest using enhanced blood flow computations based on invasive physiological measurements of the patient is disclosed. Non-invasive patient data including medical image data is received and a patient-specific anatomical model the patient's vessels is generated. Invasive physiological measurements of the patient are received and a computational blood flow model is personalized using the invasive physiological measurements. Blood flow is simulated in the patient-specific anatomical model and one or more hemodynamic quantities of interest are computed using the personalized computational blood flow model.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: December 22, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Lucian Mihai Itu, Tiziano Passerini, Puneet Sharma, Thomas Redel
  • Patent number: 10706554
    Abstract: The present disclosure includes methods and systems for identifying and manipulating a segment of a three-dimensional digital model based on soft classification of the three-dimensional digital model. In particular, one or more embodiments of the disclosed systems and methods identify a soft classification of a digital model and utilize the soft classification to tune segmentation algorithms. For example, the disclosed systems and methods can utilize a soft classification to select a segmentation algorithm from a plurality of segmentation algorithms, to combine segmentation parameters from a plurality of segmentation algorithms, and/or to identify input parameters for a segmentation algorithm. The disclosed systems and methods can utilize the tuned segmentation algorithms to accurately and efficiently identify a segment of a three-dimensional digital model.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: July 7, 2020
    Assignee: ADOBE INC.
    Inventors: Vladimir Kim, Aaron Hertzmann, Mehmet Yumer
  • Patent number: 10675485
    Abstract: A radiation dosage monitoring system comprising a 3D camera operable to obtain images of a patient undergoing radiation treatment, the 3D camera being operable to detect Cherenkov radiation and any subsequent secondary and scattered radiation originating due the initial Cherenkov radiation emitted from a surface of the patient when the patient is irradiated by a radiation beam; and a processing module operable to process the images obtained by the 3D camera utilizing data indicative of chromophores present in a patient's skin to apply a correction factor to such images to account for absorption of Cherenkov radiation by chromophores in the skin when utilizing the images to generate a representation of radiation applied to the surface of the patient.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: June 9, 2020
    Assignee: Vision RT Limited
    Inventors: Gideon Matthew Hale, Ivan Daniel Meir, Todd Pawlicki, Martin Allen
  • Patent number: 10671918
    Abstract: Techniques facilitating attention based sequential image processing are provided. A system can comprise a memory that stores computer executable components and a processor that executes the computer executable components stored in the memory. The computer executable components can comprise an initialization component that can perform self-attention based training on a model that comprises context information associated with a sequence of images. Images of the sequence of images can be selected during the self-attention based training. The computer executable components can also comprise a localization component that can extract local information from the images selected during the self-attention based training based on the context information. In addition, the computer executable components can also comprise an integration component that can update the model based on an end-to-end integrated attention training framework comprising the context information and the local information.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: June 2, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Peng Gao, Xiu Li Li, Yong Qin, Shi Lei Zhang, Xiaolu Zhang, Xin Zhang, Shi Wan Zhao
  • Patent number: 10638940
    Abstract: Electrocardiogram (ECG)-gated cardiac magnetic resonance imaging (MRI) alone may be unable to capture the hemodynamics associated with arrhythmic events. As a result, values such as ejection fraction are acquisition dependent. The desired RR-duration determines the arrhythmia rejection. By combining real-time volume measurements with ECG recordings, beat morphologies can be categorized and a more comprehensive evaluation of ventricular function during arrhythmia can be provided.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: May 5, 2020
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Walter R. T. Witschey, Francisco Contijoch, Robert C. Gorman, Yuchi Han
  • Patent number: 10588702
    Abstract: A surgical navigation system and method for identifying positions on a patient, including a processor, and a tracking system for tracking a pointer tool. The processor is programmed to initialize a surface trace acquisition, continuously record the positions of the pointer tool during the surface, conduct trace acquisition, combine the positions recorded during the surface trace acquisition into a surface trace, receive a patient image of the patient, extract a surface from the patient image, compute a registration transform between the surface traces and the surface for patient registration, segment the patient image into a regions where each region contains an anatomical landmark, determine a spatial distribution of surface traces among the regions; determine whether the spatial distribution in relation to each region minimizes deviance below a threshold, and if the determination is exceeding the threshold, provide information relating to such region.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: March 17, 2020
    Inventors: Neil Jeffrey Witcomb, Sepide Movaghati, Adam Taylor Scott
  • Patent number: 10467815
    Abstract: A processing device generates a visual overlay comprising a virtual model of a dental arch that represents a treatment outcome for the dental arch. The processing device outputs the visual overlay to an augmented reality (AR) display or virtual reality (VR) display. The processing device receives user input based on a user interaction with the virtual model of the dental arch, wherein the user input modifies the virtual model of the dental arch and determines an update to the treatment outcome for the dental arch based on a user input. The processing device generates an updated treatment plan based on the update to the treatment outcome and updates the visual overlay, wherein the updated visual overlay comprises a view of the dental arch after the updated treatment outcome.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: November 5, 2019
    Assignee: Align Technology, Inc.
    Inventors: Ozi Marom, Assaf Weiss, Maayan Moshe, Yingjie Li, Phillip Thomas Harris, Maurice K. Carrier
  • Patent number: 10290103
    Abstract: A method, device and non-transitory digital storage medium for estimating non-aqueous tissue volume of at least a portion of a subject. The method includes, in a processing unit, obtaining quantitative magnetic resonance properties of the portion of the subject, providing the quantitative magnetic resonance properties as input to a tissue model, and determining the non-aqueous tissue volume of the portion based on the tissue model and the quantitative magnetic resonance properties.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: May 14, 2019
    Assignee: Synthetic MR AB
    Inventor: Marcel Warntjes
  • Patent number: 10194829
    Abstract: During operation, a system iteratively captures MR signals of one or more types of nuclei in one or more portions of a biological lifeform based on scanning instructions that correspond to a dynamic scan plan. The MR signals in a given iteration may be associated with voxels having associated sizes at three-dimensional (3D) positions in at least a corresponding portion of the biological lifeform. If the system detects a potential anomaly when analyzing the MR signals from the given iteration, the system dynamically modifies the scan plan based on the detected potential anomaly, a medical history and/or an MR-scan history. Subsequent measurements of MR signals may be associated with the same or different: types of nuclei, portions of the biological lifeform, voxels sizes and/or 3D positions.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: February 5, 2019
    Assignee: Q Bio, Inc.
    Inventors: Jeffrey Howard Kaditz, Andrew Gettings Stevens
  • Patent number: 10139462
    Abstract: A magnetic resonance imaging (MRI) apparatus and a magnetic resonance spectroscopic method are provided. The MRI apparatus includes a data collector configured to obtain reference data of reference substances, and obtain measurement data of a target region of a subject. The MRI apparatus further includes a processor configured to determine a reference substance of the target region, among the reference substances, and a concentration of the reference substance, using the reference data, the measurement data, and an external factor compensation value compensating an external factor affecting the measurement data.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: November 27, 2018
    Assignees: SAMSUNG ELECTRONICS CO., LTD., KOREA BASIC SCIENCE INSTITUTE
    Inventors: Hyeon-Man Baek, Nam Gyun Lee, Chae Joon Cheong
  • Patent number: 10127657
    Abstract: Systems and methods of valve quantification are disclosed. In one embodiment, a method of mitral valve quantification is provided. The method includes generating a 3-D heart model, defining a 3-D mitral valve annulus, fitting a plane through the 3-D mitral valve annulus, measuring the distance between at least two papillary muscle heads, defining an average diameter of at least one cross section around the micro valve annulus, and determining a size of an implant to be implanted.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: November 13, 2018
    Assignee: MATERIALISE N.V.
    Inventors: Nicolo Piazza, Peter Verschueren, Todd Pietila
  • Patent number: 10039473
    Abstract: A method of tracking a medical instrument comprises receiving a model of an anatomical passageway formation and receiving a set of ordered sensor records for the medical instrument. The set of ordered sensor records provide a path history of the medical instrument. The method further comprises registering the medical instrument with the model of the anatomical passageway formation based on the path history.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: August 7, 2018
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Tao Zhao, Prashant Chopra, Vincent Duindam, Dorin Panescu, Lei Fan
  • Patent number: 9959673
    Abstract: A method for improving the image quality of a three-dimensional magnetic resonance image dataset recorded with a magnetic resonance device, wherein, from at least one correction image dataset recorded with a modality other than magnetic resonance imaging, registered with the magnetic resonance image dataset, showing at least partly the same recording region as the magnetic resonance image dataset, especially an x-ray image dataset, relevant material parameters are derived locally-resolved for the magnetic resonance imaging, which are used for establishing a virtual magnetic resonance comparison dataset in a simulation wherein, as a function of a comparison between the magnetic resonance image dataset and the magnetic resonance comparison dataset, at least one measure parameter describing an image quality improvement measure to be applied in the k-space is determined and the image quality improvement measure is carried out with the measure parameter relating to the magnetic resonance image dataset.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: May 1, 2018
    Assignee: Siemens Aktiengesellschaft
    Inventors: Dirk Ertel, Yiannis Kyriakou
  • Patent number: 9931177
    Abstract: A method of producing a dental splint comprising the steps of: obtaining a set of 3D surface data, the 3D surface data representing a surface of a patient's oral situation, and generating a support structure model in dependence on the 3D surface data, and producing the dental splint in dependence on the support structure model, wherein a 3D distance map image of the 3D surface data is used to generate the support structure model.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: April 3, 2018
    Assignee: Nobel Biocare Services AG
    Inventors: Veerle Wouters, Wouter Mollemans, Filip Schutyser, Pascal Kunz
  • Patent number: 9721379
    Abstract: A method includes registering a first coordinate system of a fluoroscopic imaging system and a second coordinate system of a magnetic position tracking system. A three-dimensional (3D) map of an organ of a patient is computed using the magnetic position tracking system. A field-of-view (FOV) of the fluoroscopic imaging system in the second coordinate system is calculated using the registered first and second coordinate systems. Based on the 3D map and the calculated FOV, a two-dimensional (2D) image that simulates a fluoroscopic image that would be generated by the fluoroscopic imaging system is created, and the 2D image that simulates the fluoroscopic image is displayed.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: August 1, 2017
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Eliahu Zino, Gil Zigelman, Liav Moshe Adi
  • Patent number: 9684957
    Abstract: Systems, methods, and media for detecting an anatomical object in a medical device image are provided. In some embodiments, system for detecting an anatomical object in a medical device image are provided, the systems comprising: at least one hardware processor that: applies the medical device image to a classifier having a plurality of stages, wherein a first stage of the plurality of stages and a second stage of the plurality of stages each includes a strong learner formed from a plurality of weak learners, and the weak learners in the second stage include a plurality of the weak learners included in the first stage; and identifies the medical device image as being positive or negative of showing the anatomical object based on the application the medical device image to be classifier.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: June 20, 2017
    Assignee: Arizona Board of Regents, a body corporate of the State of Arizona, acting for and on behalf of Arizona State University
    Inventors: Hong Wu, Kun Deng, Jianming Liang
  • Patent number: 9633470
    Abstract: To make it possible to generate slice data without the need to modify a polygon mesh that does not satisfy conditions of a perfect solid model. A slice data generator for generating slice data representing a cross section cut from a three-dimensional modeled object, wherein the slice data generator has: changing means for changing topology information of a polygon mesh so that a contour polyline is obtained indicating a contour line of a cut cross section of the polygon mesh; and modifying means for acquiring the contour polyline from the polygon mesh, the topology information of the polygon mesh having been changed by the changing means, and modifying the contour polyline so that an inside which is a region inside the acquired contour polyline can be normally filled; slice data being generated on the basis of the contour polyline modified by the modifying means.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 25, 2017
    Assignee: Roland DG Corporation
    Inventors: Takayuki Sakurai, Yasutoshi Nakamura
  • Patent number: 9601030
    Abstract: A method and system are presented for performing virtual surgery simulations. The computer system includes a processor and a memory. The method includes receiving user input from a user via a user interface. The user input includes input representing surgical operations or non-surgical invasive procedures. The method also includes processing the user input and utilizing the input to generate or modify a computational model. The method also includes running simulations using the computational model in accordance with the user input. After running the simulations, the method further includes determining results from the simulations. The results correspond to probable effects or outcomes of performing real life surgical operations or non-surgical invasive procedures corresponding to the user input. Last, the method includes presenting the results to the user via the user interface.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 21, 2017
    Inventors: Mark B. Ratcliffe, Liang Ge, Alan Bao-Chan Dang
  • Patent number: 9589379
    Abstract: A system and method for visualization of cardiac changes under various pacing conditions for intervention planning and guidance is disclosed. A patient-specific anatomical heart model is generated based on medical image data of a patient. A patient-specific computational model of heart function is generated based on patient-specific anatomical heart model. A virtual intervention is performed at each of a plurality of positions on the patient-specific anatomical heart model using the patient-specific computational model of heart function to calculate one or more cardiac parameters resulting from the virtual intervention performed at each of the plurality of positions. One or more outcome maps are generated visualizing, at each of the plurality of positions on the patient-specific anatomical heart model, optimal values for the one or more cardiac parameters resulting from the virtual intervention performed at the that position on the patient-specific anatomical heart model.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: March 7, 2017
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Tommaso Mansi, Tiziano Passerini, Ali Kamen, Bogdan Georgescu, Dorin Comaniciu
  • Patent number: 9392992
    Abstract: High intensity focused ultrasound (HIFU) is registered with imaging. The effects of transmission from a HIFU transducer, such as a rise in temperature, are detected by a separate imaging system. By using multiple transmissions, a plurality of locations of the transmissions from the HIFU transducer are determined within the imaging system coordinates. A transform relating the imaging system coordinates to the HIFU transducer coordinates is determined from the detected effects. The transform may be used to relate locations indicated in images of the imaging system with coordinates of the HIFU transducer for application of HIFU. The imaging system may not have to scan the HIFU transducer or fiducials and a fixed relationship may not be needed.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 19, 2016
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventors: Stephen J. Hsu, Liexiang Fan, Kevin Michael Sekins
  • Patent number: 9301733
    Abstract: Systems and methods for ultrasound image rendering are provided. One system includes a user interface having a display configured to display ultrasound images for a volume data set and a content detection module configured to detect an object within the volume data set. The system also includes an image-processing module configured to receive ultrasound signals from a diagnostic probe and process the signals to generate the ultrasound images. The image-processing module is further configured to locally change an opacity function of the displayed ultrasound image based on the detected object to change an opacity of a subset of voxels in the volume data set.
    Type: Grant
    Filed: December 31, 2012
    Date of Patent: April 5, 2016
    Assignee: General Electric Company
    Inventors: Olivier Gerard, Stein Inge Rabben, Erik Normann Steen
  • Patent number: 9105239
    Abstract: There is provided an image processing device including a movement section which scrolls a medical image on a screen, and a display control section which, in a case where the medical image is scrolled on the screen, controls a display section to display the medical image in a manner that an observation reference position of a diagnosis region of the medical image passes through a display reference position of a display region of the screen.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: August 11, 2015
    Assignees: Sony Corporation, Japanese Foundation For Cancer Research
    Inventors: Takeshi Ohashi, Jun Yokono, Takuya Narihira
  • Patent number: 9092886
    Abstract: The invention relates to a rendering system (100) for rendering a view from an image dataset, the rendering system comprising a selecting unit (110) for selecting a subset of the image dataset, a computing unit (120) for computing a first principal axis of a tensor on the basis of the subset of the image dataset, and a rendering unit (130) for rendering the view on the basis of the first principal axis. Using the information about the directionality and orientation of a structure, comprised in the selected subset of the image dataset and extracted from the first principal axis of the tensor, the rendering system (100) is arranged to effectively assist the user in selecting an advantageous view from the image dataset.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: July 28, 2015
    Assignee: Koninklijke Philips N.V.
    Inventors: Rafael Wiemker, Thomas Buelow, Thomas Blaffert
  • Patent number: 9042613
    Abstract: Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model. The method also includes determining, for each of the plurality of treatment options, a value of a blood flow characteristic, by solving at least one of the modified three-dimensional model and the modified reduced order model; and identifying one of the plurality of treatment options that solves a function of at least one of: the determined blood flow characteristics of the patient's heart or vasculature, and one or more costs of each of the plurality of treatment options.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: May 26, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Ryan Spilker, David Eberle, Leo Grady
  • Patent number: 9041712
    Abstract: A method, apparatus, article of manufacture, and computer program product display multiple slices of a three-dimensional body in a computer drawing application. A first view of a 3D body is displayed. One or more slice sketches are defined on the first view. A single slice view of the three dimensional body is displayed. The single slice view simultaneously depicts all of the slices with a zero-depth representation of each slice.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: May 26, 2015
    Assignee: Autodesk, Inc.
    Inventors: Michael A. Bogues, Tyler J. Henderson, Hans Walter Herzog, Yun Chen, Shivakumar Sundaram
  • Patent number: 9002690
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: April 7, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Publication number: 20150065864
    Abstract: A method and system for non-invasive assessment of renal artery stenosis is disclosed. A patient-specific anatomical model of at least a portion of the renal arteries and aorta is generated from medical image data of a patient. Patient-specific boundary conditions of a computational model of blood flow in the portion of the renal arteries and aorta are estimated based on the patient-specific anatomical model. Blood flow and pressure are simulated in the portion of the renal arteries and aorta using the computational model based on the patient-specific boundary conditions. At least one hemodynamic quantity characterizing functional severity of a renal stenosis region is calculated based on the simulated blood flow and pressure in the portion of the renal arteries and aorta.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 5, 2015
    Inventors: Puneet Sharma, Saikiran Rapaka, Viorel Mihalef, Ali Kamen
  • Publication number: 20150051479
    Abstract: A system and method for sampling k-space is provided that substantially simplifies the demands placed on the clinician to select and balance the tradeoffs of a particular selected sampling methodology. In particular, the present invention provides particularly advantageous sampling methodologies that simplify the selection of a particular k-space sampling methodology and, furthermore, the tradeoffs within a particular sampling methodology.
    Type: Application
    Filed: March 27, 2013
    Publication date: February 19, 2015
    Applicant: DIGNITY HEALTH
    Inventor: James G. Pipe
  • Publication number: 20140378826
    Abstract: A system and method for producing an image of a vascular structure of a subject using a magnetic resonance imaging (MRI) system includes performing a first pulse sequence to acquire a flow-dependent imaging data set from the stack of prescribed imaging slices following a first quiescent inflow time period (QITP). The process also includes performing a second pulse sequence without suppressing signal from spins flowing into the stack of prescribed imaging slices through either of the veins or arteries to acquire a flow-independent imaging data set. The flow-dependent imaging data and the flow-independent imaging data are subtracted to create a difference image of the stack of prescribed imaging slices illustrating the at least one of the arteries and the veins as having a bright contrast and another of the arteries and veins as having a suppressed contrast.
    Type: Application
    Filed: June 13, 2014
    Publication date: December 25, 2014
    Inventor: Robert R. Edelman
  • Patent number: 8914264
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 16, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Publication number: 20140364723
    Abstract: A method is provided for identifying a muscle abnormality. The method may include acquiring image data associated with a plurality of muscles in an area of interest of a living subject and generating a data model for the plurality of muscles based on the image data. The method further includes calculating the volume and/or length of one of the plurality of muscles based on the data model, and determining if the volume and/or length for the muscle, as calculated, deviates from volume and/or length associated with a healthy muscle. If it is determined that the volume and/or length for the muscle deviates from the volume and/or length associated with a healthy muscle, a muscle abnormality can be identified based on the deviation.
    Type: Application
    Filed: August 13, 2012
    Publication date: December 11, 2014
    Inventors: Craig Meyer, Silvia Blemker, Geoffrey Handsfield, Mark F. Abel
  • Publication number: 20140350386
    Abstract: The invention relates to a method of MR imaging of at least two chemical species having different MR spectra. It is an object of the invention to provide a method that enables Dixon water/fat separation in cases in which a large field-of-view is required. The method of the invention comprises the steps of: a) generating at least one echo signal by subjecting a body placed in the examination volume of a MR device to an imaging sequence of RF pulses and switched magnetic field gradients; b) acquiring the at least one echo signal; c) separating signal contributions of the at least two chemical species to the at least one acquired echo signal on the basis of a spectral model and prior knowledge about the spatial variation of the main magnetic field B0 in the examination volume; and d) reconstructing a MR image from the signal contributions of at least one of the chemical species. Moreover the invention relates to a MR device and to a computer program to be run on a MR device.
    Type: Application
    Filed: December 10, 2012
    Publication date: November 27, 2014
    Applicant: Koninklijke Philips N.V.
    Inventors: Holger Eggers, Clemens Bos
  • Patent number: 8888717
    Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: November 18, 2014
    Assignee: Allergan, Inc.
    Inventors: David H. Mordaunt, G. Patrick Maxwell, Thomas J. Liolios
  • Publication number: 20140316250
    Abstract: MRI techniques seek to simultaneously measure physiological parameters in multiple directions, requiring the application of multiple encoding magnetic field gradient waveforms. The use of multiple encoding waveforms degrades the temporal resolution of the measurement, or may distort the results depending on the methodology used to derive physiological parameters from the measured data. The disclosed Direct Inversion Reconstruction Method (DiR) provides distortion-free velocity images with high temporal resolution, without changing the method of acquiring the phase data. The disclosed method provides a more stable and accurate recovery of phase-based dynamic magnetic resonance signals with higher temporal resolution than current state-of-the-art methods.
    Type: Application
    Filed: April 22, 2014
    Publication date: October 23, 2014
    Applicant: Ohio State Innovation Foundation
    Inventors: Rizwan Ahmad, Orlando P. Simonetti, Yu Ding, Ning Jin
  • Patent number: 8861815
    Abstract: Systems and methods for modeling functional magnetic resonance image datasets using a multivariate auto-regressive model which captures temporal dynamics in the data, and creates a reduced representation of the dataset representative of functional connectivity of voxels with respect to brain activity. Raw spatio-temporal data is processed using a multivariate auto-regressive model, wherein coefficients in the model with high weights are retained as indices that best describe the full spatio-temporal data. When there are a relatively small number of temporal samples of the data, sparse regression techniques are used to build the model. The model coefficients are used to perform data processing functions such as indexing, prediction, and classification.
    Type: Grant
    Filed: August 3, 2011
    Date of Patent: October 14, 2014
    Assignee: International Business Machines Corporation
    Inventors: Guillermo Alberto Cecchi, Rahul Garg, Ravishankar Rao
  • Patent number: 8855984
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: October 7, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 8855741
    Abstract: A method of acquiring an image biomarker suitable for prognosis of a blood-related disease, such as acute myeloid leukemia, includes the steps of: (a) acquiring physical parameter sets, each including at least two parameters, respectively from time-signal intensity curves, these curves being respectively obtained from magnetic resonance image sets of different subjects; each of the image sets being acquired through MRI scanning using one of first and second configuration parameter sets; (b) analyzing the physical parameter sets thus acquired and (c) establishing a risk score function that is a sum of products of each of the physical parameters and the corresponding weight value, wherein a risk score obtained using the risk score function serves as the image biomarker suitable for prognosis of the blood-related disease.
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: October 7, 2014
    Assignee: National Taiwan University
    Inventors: Tiffany Ting-Fang Shih, Timothy K. Shih
  • Publication number: 20140296702
    Abstract: Three-dimensional (3D) projections of nuclear magnetic resonance (NMR) signals are acquired from a liver experiencing NMR in response to a 3D multi-echo non-Cartesian pulse sequence. The projections are reconstructed into two sets of images having different resolutions. Bins associated with the different positions to which the liver moves during respiration are identified in lower resolution images, and then higher resolution images are binned into the position dependent bins based on navigator data in the lower resolution images. A combined image for a bin is made from images located in the bin and then registered to a reference image. An overall combined image is made by summing the combined bin images. Quantized data for a contrast agent concentration in the liver is produced using signal intensity in the overall combined image. The quantized value may describe a liver perfusion parameter. A diagnosis may be made from the quantized value.
    Type: Application
    Filed: February 11, 2014
    Publication date: October 2, 2014
    Applicant: Case Western Reserve University
    Inventors: Mark Griswold, Vikas Gulani, Greg Lee, Nicole Seiberlich
  • Patent number: 8834391
    Abstract: Various methods, techniques or modules are provided to allow for the automated analysis of the 3-D representation of the upper front torso (i) to recognize 3-D anatomical features, (ii) to orient the subject with reference to their anatomy or a display, (iii) to determine dimensional analysis including direct point-to-point lines, 3-D surface lines, and volume values, (iv) to simulate the outcome with the addition of breast implants including breast and nipple positioning, (v) to assist in the selection of the breast implants, and/or (vi) to assist in the planning of breast surgery. The automated analysis is based on the analysis of changes in a 3-D contour map of the upper torso, orientation analysis of 3-D features and planes, color analysis of 3-D features, and/or dimensional analysis of 3-D features and positions of the upper torso.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 16, 2014
    Assignee: Allergan, Inc.
    Inventors: David H. Mordaunt, G. Patrick Maxwell
  • Patent number: 8812431
    Abstract: A method and system for providing medical decision support based on virtual organ models and learning based discriminative distance functions is disclosed. A patient-specific virtual organ model is generated from medical image data of a patient. One or more similar organ models to the patient-specific organ model are retrieved from a plurality of previously stored virtual organ models using a learned discriminative distance function. The patient-specific valve model can be classified into a first class or a second class based on the previously stored organ models determined to be similar to the patient-specific organ model.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: August 19, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Ingmar Voigt, Dime Vitanovski, Razvan Ioan Ionasec, Alexey Tsymbal, Bogdan Georgescu, Shaohua Kevin Zhou, Martin Huber, Dorin Comaniciu
  • Patent number: 8805048
    Abstract: A method for generating a cephalometric analysis of an orthodontic patient is disclosed. A sequence of images that may each correspond to a specific anatomical plane of the patient is received. Then, a volumetric representation of the patient is derived from a combination of the sequence of the images. One or more markers associated with particular anatomical landmarks of the patient according to a predefined analysis method are received. The markers are defined by a set of coordinate values, and are designated via an interactive user interface to a two-dimensional representation derived from the volumetric representation. Connectors between one or more of the markers are generated in accordance with the predefined analysis method, and a visual representation of the markers and the connectors are overlaid on the volumetric representation.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: August 12, 2014
    Inventor: Mark Batesole
  • Patent number: 8781554
    Abstract: A method for simulating magnetic resonance signals is proposed. A lattice array where each point in the array has several magnetic resonance sensitive particles is provided. Statistic property of each point is set. A raw magnetic resonance imaging data is calculated based on statistic property of each point and a magnetic resonance imaging sequence to be applied. A system for simulating magnetic resonance signals is further proposed. By considering statistic property of each point, it can distinguish every part of the object to be scanned and really reflect the structure of object without using a real magnetic resonance imaging device. It saves time and costs for avoiding several scanning by the real a magnetic resonance imaging device.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: July 15, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Oliver Schreck, Rui Zhang, Shi Gang Zhang, Hai Yan Zhou
  • Patent number: 8774898
    Abstract: The present invention relates to a method of characterising tissue function in a subject in need of such characterization. The method comprises performing an imaging technique, on a voxel defined within a tissue space of interest, wherein image data is generated over a time period during which the subject inhales gases with at least two different partial pressures of a paramagnetic gas. A compartmental model algorithm is applied to the image data generated for the voxel to provide information on metabolic function of the tissue.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: July 8, 2014
    Assignee: BIOxyDyn Limited
    Inventors: Deirdre McGrath, Geoffrey Parker
  • Patent number: 8768669
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 1, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 8768670
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: July 1, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Publication number: 20140180061
    Abstract: A computerized method of generating a map of myelin tissue of a brain is described. In addition sub-maps of different myelin contents can be imaged. The method uses a simulation model comprising at least two interacting tissue compartments.
    Type: Application
    Filed: October 14, 2010
    Publication date: June 26, 2014
    Inventor: Marcel Warntjes
  • Patent number: 8750583
    Abstract: A method of surgical modeling is disclosed. A set of related two-dimensional (2D) anatomical images is displayed. A plurality of anatomical landmarks is identified on the set of related 2D anatomical images. A three-dimensional (3D) representation of at least one prosthesis is scaled to match a scale of the 2D anatomical images based at least in part on a relationship between the anatomical landmarks. 3D information from the at least one prosthesis along with information based on at least one of the plurality of anatomical landmarks is utilized to create procedure-based information. A system for surgical modeling is also disclosed. The system has a prosthesis knowledge-based information system, a patient anatomical-based information system, a user interface, and a controller. The controller has an anatomical landmark identifier, a prosthesis-to-anatomical-feature relator, and a procedure modeler.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: June 10, 2014
    Assignee: FUJIFILM Medical Systems USA, Inc.
    Inventors: James Andrew Zug, Micah Aaron Forstein, Emil Michael Saraga, Jr.
  • Patent number: 8718747
    Abstract: The invention provides a method, an image analysis software product, and a system for medical imaging analysis for estimating contrast agent extravasation in contrast agent based perfusion imaging such as MRI dynamic contrast enhanced (DCE) imaging, and in particular correction, compensation, or visualization of extravascular leakage of contrast agent in tumors. According to the invention, the effect of extravasation is directly manifested in the tail part of an observed, apparent residue function, R?(t), obtained directly by de-convoluting the expression C(t)=R?(t)Cp?(t) with the arterial input function (AIF). A leakage rate or extravasation constant is determined directly from the tail part of the determined apparent residue function.
    Type: Grant
    Filed: April 18, 2011
    Date of Patent: May 6, 2014
    Assignee: Oslo Universitetssykehus HF
    Inventors: Atle Bjørnerud, Kyrre Eeg Emblem
  • Publication number: 20140114178
    Abstract: A computer-implemented method for concurrently estimating the amount of fat and iron in anatomical tissue from magnetic resonance (MR) signal data includes receiving a test signal representative of the anatomical tissue acquired using a MR pulse sequence type. A repository of reference signal data is generated. The repository comprises a plurality of reference signals derived by an MR signal simulation for a plurality of different transverse relaxation rates, a plurality of different fat fractions, and the MR pulse sequence type. A first reference signal is identified in the plurality of reference signals. The first reference signal provides a best match to the test signal based on one or more matching criteria. The repository is searched to determine a first transverse relaxation rate and a first fat fraction associated with the first reference signal. Then, the amount of fat and iron in the anatomical tissue is estimated based on the first transverse relaxation rate and the first fat fraction.
    Type: Application
    Filed: October 24, 2013
    Publication date: April 24, 2014
    Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.
    Inventor: Brian Dale
  • Patent number: 8706457
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: April 22, 2014
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens