Of Fluid Flow Patents (Class 600/419)
  • Patent number: 10310040
    Abstract: In a magnetic resonance apparatus and method for acquiring magnetic resonance data, a magnetic resonance data acquisition scanner executes a turbo spin echo (TSE) data acquisition sequence with simultaneous multi-slice (SMS) imaging wherein nuclear spins in two different slices of an examination subject are simultaneously excited so as to produce respective echo trains. The magnetic resonance data acquisition scanner is operated with the SMS imaging configured so that magnetic resonance signals from the respective slices have a different contrast, with the SMS being configured to allow evolution of magnetization of the nuclear spins for the second contrast while magnetic resonance signals with the first contrast are being detected. The respective magnetic resonance signals from the two different slices are detected and entered into an electronic memory organized as k-space, as k-space data.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: June 4, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Himanshu Bhat, Pedro Miguel Itriago Leon, Mario Zeller
  • Patent number: 10274558
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes sequence controlling circuitry and image generating circuitry. The sequence controlling circuitry acquires magnetic resonance signals in an imaging region. The image generating circuitry generates an image. The sequence controlling circuitry sets timings of RF pulses such that a first time and a second time are different. Here, the first time is a time since an irradiation of a first RF pulse without selection of region until a start of acquisition. The second time is a time since an irradiation of a second RF pulse with selection of the labeling region until the start of acquisition. The second time is also a time for a liquid present in the labeling region to reach a desired position in the imaging region. The first time is also a time for longitudinal magnetization components of a background tissue to become substantially zero.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: April 30, 2019
    Assignees: KYOTO UNIVERSITY, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Hiroyoshi Isoda, Koji Fujimoto, Hiroshi Kusahara
  • Patent number: 10188355
    Abstract: Embodiments relate to a method and system to improve fat suppression and reduce motion and off-resonance artifacts in magnetic resonance imaging (MRI) by using a background-suppressed, reduced field-of-view (FOV) radial imaging. The reduction of such artifacts provides improved diagnostic image quality, higher throughput of MRI scans for the imaging center, and increased patient comfort. By using a small FOV radial acquisition that only encompasses the structures of interest, structures that cause motion artifacts, such as the anterior abdominal wall, bowel loops, or blood vessels with pulsatile flow, are excluded from the image. According to an embodiment, combining a small FOV radial acquisition with one or more background-suppression techniques minimizes the impact of artifacts caused by anatomy outside of the FOV.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: January 29, 2019
    Assignees: Siemens Healthcare GmbH, Northshore University Healthsystem
    Inventors: Shivraman Giri, Robert R. Edelman, Ioannis Koktzoglou
  • Patent number: 10139460
    Abstract: A delta-relaxation magnetic resonance imaging (DREMR) system is provided. The system includes a main field magnet and field shifting coils. A main magnetic field with a strength B0 can be generated using the main filed magnet and the strength B0 of the main magnetic field can be varied through the use of the field-shifting coils. The DREMR system can be used to perform signal acquisition based on a pulse sequence for acquiring at least one of T2*-weighted signals imaging; MR spectroscopy signals; saturation imaging signals and MR signals for fingerprinting. The MR signal acquisition can be augmented by varying the strength B0 of the main magnetic field for at least a portion of the pulse sequence used to acquire the MR signal.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: November 27, 2018
    Assignee: SYNAPTIVE MEDICAL (BARBADOS) Inc.
    Inventors: Alexander Gyles Panther, Cameron Anthony Piron, Jeff Alan Stainsby, Chad Tyler Harris
  • Patent number: 10016413
    Abstract: The present invention is directed to a method of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject an effective amount of a dopamine antagonist and a opiate receptor antagonist or a composition comprising same. Further provided are pharmaceutical compositions comprising, as active substances, at least one dopamine antagonist and at least one opiate receptor antagonist.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: July 10, 2018
    Assignee: University of Maryland, Baltimore
    Inventors: Jia Bei Wang, Sarah Sushchyk
  • Patent number: 10004422
    Abstract: A method for chemical exchange saturation transfer (“CEST”) imaging that is more insensitive to off-resonance and magnetization transfer effects than other CEST methods is provided. Sn general, three different images are obtained: one obtained with radio frequency (“RF”) saturation about a labeling frequency, one obtained with RF saturation about a reference frequency, and one obtained with RF saturation about both the labeling and reference frequencies. This method, termed saturation with frequency alternating radiofrequency irradiation (“SAFARI”), is also very robust to magnetic field inhomogeneities. The three images, referred to as a labeled image, reference image, and dual frequency image, are selectively combined to produce an image of the subject in which CEST contrast is present, but errors arising from off-resonance and magnetization transfer effects are substantially suppressed.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: June 26, 2018
    Assignee: Beth Israel Deaconess Medical Center
    Inventors: David Alsop, Rachel Scheidegger
  • Patent number: 9983286
    Abstract: A magnetic resonance imaging (MRI) system, method and/or computer readable medium is configured reduce specific absorption rate (SAR) in Fast Advanced Spin Echo (FASE) or Single-shot Fast Spin Echo (SS-FSE) imaging used, for example, in non-contrast magnetic resonance angiography (NC-MRA) techniques like fresh blood imaging (FBI). Within RF pulse sequences used to acquire echo data, the refocusing flip angles may be varied in the phase encode direction, and/slice encode direction, such that the refocusing pulse (or pulses) that map echo signals to the k-space center region larger refocusing flip angles than refocusing pulses used to generate echo signals that map to other areas of k-space. In some instances, the TR interval also may be varied for RF pulse sequences such that central K-space have a longer TR than the slices further towards the ends.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: May 29, 2018
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Xiangzhi Zhou, Yoshimori Kassai
  • Patent number: 9974511
    Abstract: A medical imaging apparatus according to a present embodiment includes processing circuitry. The processing circuitry obtains pieces of medical image data, the pieces each being generated in each of multiple time phases and each including bone information. The processing circuitry sets first regions each being included in each of the pieces. The processing circuitry generates pieces of corrected medical image data by aligning the pieces of medical image data so that the first regions are substantially a same position. The processing circuitry specifies second regions each corresponding to a bone moving in the pieces of the corrected medical image data. The processing circuitry displays the second regions so as to be recognized on a display.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: May 22, 2018
    Assignee: Toshiba Medical Systems Corporation
    Inventor: Megumu Fujiwara
  • Patent number: 9974464
    Abstract: An image processing apparatus according to an embodiment includes a processor and a memory. The memory stores processor-executable instructions that, when executed by the processor, cause the processor to: receive an input of information designating an observation target; extract, from each of magnetic resonance (MR) images included in an MR image group collected by applying a tagging pulse to a region where a fluid flows, a group of regions of the fluid; analyze, by an analyzing method associated with the observation target, the group of regions of the fluid extracted from each of the MR images, thereby deriving an index indicating a dynamic state of the fluid; and cause the index to be displayed on a display.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 22, 2018
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Taichiro Shiodera, Shuhei Nitta, Tomoyuki Takeguchi
  • Patent number: 9968409
    Abstract: This system is a system for analyzing blood flow of a target vascular site by means of simulation, having a fluid analysis unit, by a computer, for determining state quantities of blood flow at each position of a lumen of the target vascular site by means of computation by imposing computational conditions including boundary conditions relating to the blood flow to three-dimensional shape data of the target vascular site; a three-dimensional shape modification unit for modifying the three dimensional shape data by simulating a surgical treatment method and for outputting the three-dimensional shape data after the modification; and a comparison display unit for displaying computed results of before and after the modification of the three-dimensional shape for comparing the results, by causing the fluid analysis unit to re-compute the state quantities based on the three-dimensional shape data after the modification.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: May 15, 2018
    Assignee: EBM CORPORATION
    Inventors: Takanobu Yagi, Young-Kwang Park
  • Patent number: 9964621
    Abstract: A method and apparatus for reducing scan time, eddy currents and image factors in dynamic magnetic resonance (MR) imaging associated with at least a portion a k-space. The method includes scanning at least a portion of the k-space with an Echo-Planar Imaging (EPI) pulse sequence technique, acquiring a randomly under-sampled k-space; and reconstructing the under-sampled k-space utilizing a constrained reconstruction technique. A dynamic image is constructed of the at least a portion of the k-space based on EPI and the randomly undersampled k-space techniques to each segment of the EPI pulse sequence technique.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: May 8, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Tamer Basha, Reza Nezafat
  • Patent number: 9915719
    Abstract: In a method and apparatus for recording magnetic resonance (MR) signals from an examination object, raw data space is filled with MR signals in raw data lines. Movement information of the examination object is detected during recording of the MR signals and the movement information is grouped into different movement phases of the examination object. A temporally randomly distributed sequence of the recording of the raw data lines is determined, with which at least one predetermined portion of the raw data space is filled MR signals. The MR signals are acquired in the determined temporally randomly distributed sequence of the raw data lines in the predetermined portion. Each recorded raw data line is allocated to one of the movement phases of the examination object.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: March 13, 2018
    Assignee: Siemens Healthcare GmbH
    Inventor: Stefan Popescu
  • Patent number: 9854990
    Abstract: The present disclosure relates to a brain disease diagnosis service apparatus including at least: a receiving unit for receiving an image of a subject to be diagnosed; a preprocessing unit for estimating a transformation matrix in order to align a predetermined standard image with the image received by the receiving unit, and for applying the estimated transformation matrix to a predetermined standard brain region map, thereby generating an individual brain region map for the subject to be diagnosed; a feature point extracting unit for calculating a ratio occupied by brain lesions for each brain region in the individual brain region map, generated by the preprocessing unit, of the subject to be diagnosed, thereby extracting feature points; and a disability type determining unit for determining a disability type on the basis of the ratio of the brain lesions, calculated by the feature point extracting unit, for each brain region.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: January 2, 2018
    Assignee: THE ASAN FOUNDATION
    Inventors: Dong Wha Kang, Yong Hwan Kim
  • Patent number: 9848850
    Abstract: A method of displaying stereoscopic information related to an ultrasound sectional plane of a target object includes setting a line of interest on the ultrasound sectional plane of the target object based on a received input; obtaining an ultrasound signal of the ultrasound sectional plane of the target object along the set line of interest; converting the obtained ultrasound signal to represent the stereoscopic information in a three-dimensional manner; and displaying the stereoscopic information related to the ultrasound sectional plane of the target object.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: December 26, 2017
    Assignees: SAMSUNG ELECTRONICS CO., LTD., SAMSUNG MEDISON CO., LTD.
    Inventors: Eun-jung Chang, Jin-yong Lee
  • Patent number: 9833166
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a specifying unit and an acquiring unit. The specifying unit specifies, on a basis of a detection result of target sites of a subject detected from an image on which the target sites are visualized, a first region and a second region which is different from the first region on the image. The acquiring unit acquires data of the second region by using an imaging condition which is different from an imaging condition on an imaging slice and used for acquiring data of the first region.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: December 5, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Kensuke Shinoda
  • Patent number: 9693706
    Abstract: An image processing apparatus according to an embodiment includes a specifying unit and a deriving unit. The specifying unit specifies a fluid region in a plurality of magnetic resonance images that are acquired by applying a labeling pulse to a label region and that are mutually related. The deriving unit derives an index indicating dynamics of a fluid on the basis of the specified fluid region.
    Type: Grant
    Filed: April 25, 2013
    Date of Patent: July 4, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Taichiro Shiodera, Shuhei Nitta, Tomoyuki Takeguchi, Nobuyuki Matsumoto
  • Patent number: 9664764
    Abstract: An MRI system acquires a susceptibility-weighted image by acquiring a first RF echo signal in a first echo time for providing an image exclusive of susceptibility-weighting and acquiring a second RF echo signal in a second echo time longer than the first echo time for providing an image including susceptibility-weighting. A compensation gradient field is applied for compensating for field inhomogeneity and in response, a third RF echo signal is acquired in a third echo time longer than the second echo time. First, second and third images are generated in response to data derived from the first, second and third RF echo signals respectively and data of the first, second and third images is combined to provide image data representing an image compensating for magnetic resonance signal attenuation in the second image.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: May 30, 2017
    Assignees: Samsung Electronics Co., Ltd., The Trustees Of The University Of Pennsylvania
    Inventors: Jin Young Hwang, Joon Soo Kim, Jae Moon Jo, Yang Lim Choi, Jongho Lee
  • Patent number: 9649041
    Abstract: According to one embodiment, a blood flow perfusion analyzing apparatus includes tissue and arterial TCC calculation units, first and second making units, a deconvolution unit and a blood flow information calculation unit. The tissue TCC calculation unit obtains tissue TCCs. The arterial TCC calculation unit calculates an arterial TCC. The first making unit makes first sets, starting from a first time in which elements corresponding to the tissue are arrayed one-dimensionally, based on the tissue TCCs. The second making unit makes a second set, starting from a second time after the first time, in which elements corresponding to the artery are arrayed two-dimensionally, based on the arterial TCC. The deconvolution unit calculates transfer functions of the tissue based on the first and second sets. The blood flow information calculation unit calculates information on a blood flow perfusion based on the transfer functions.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: May 16, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Shigeharu Ohyu, Yasuo Sakurai
  • Patent number: 9613188
    Abstract: Systems for and methods of utilizing a neuroimaging database are presented. The systems and methods include techniques for analyzing the pathophysiological basis of a chronic brain disease and/or the effectiveness of a treatment for a chronic brain disease, obtaining data for research of a chronic brain disease, searching for chronic brain disease symptoms identified in a clinical patient, searching a database by comparing the brain scan images of patients with suspected indications of chronic brain disease with other patients in the database to identify sets of patients with similar indications in their brain scan images, displaying brain scan information regarding a person, and using image pattern matching to analyze the pathophysiological basis of a chronic brain disease and/or the effectiveness of a proposed or previously administered treatment for a chronic brain disease.
    Type: Grant
    Filed: September 15, 2014
    Date of Patent: April 4, 2017
    Assignee: CERESCAN CORPORATION
    Inventors: Vincent Bradshaw, Theodore Henderson, Jennifer Faherty, Donald Bitto, Nikki Villegas-Mauter
  • Patent number: 9579041
    Abstract: A magnetic resonance imaging (MRI) system semi-automatically performs non-contrast magnetic resonance angiography (MRA). An operator display and control input port configures the MRI system to effect semi-automated non-contrast MRA imaging with spatially selective tag and venous suppression RF pulses and/or black blood time interval (BBTI) parameters in a non-contrast MRA data acquisition sequence where such parameters are automatically determined within predetermined, respectively corresponding, spatial regions of patient anatomy. Such automatically determined non-contrast MRA imaging parameters may be entirely automatically set and used or, alternatively, may be displayed to an operator for acceptance and/or change before being used.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: February 28, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Mitsue Miyazaki
  • Patent number: 9551565
    Abstract: A method and corresponding system for optical coherence tomography includes optical coherence tomography equipment that acquires at least two two-dimensional initial images of an object in planes of the object that are spaced apart from one another, in particular running parallel to one another, wherein the initial images each include a plurality of initial image values. In order to assure an examination of the object in the case of medical applications that is as reliable as possible, an interpolation of the initial image values of the at least two two-dimensional initial images is performed in three-dimensional space, wherein interpolation values are obtained that form a two-dimensional final image.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: January 24, 2017
    Assignee: AGFA HEALTHCARE NV
    Inventors: Rainer Nebosis, Roland Reuter
  • Patent number: 9545206
    Abstract: Elicited MRI signals are processed into MR image data in conjunction (a) with use of an initial spatially-selective RF tag pulse (tag-on) and (b) without use of an initial spatially-selective NMR RF tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (TI) intervals without using an injected contrast agent. Acquired image data sets are subtracted for each TI interval to produce difference values as a function of time representing blood perfusion for the ROI that differentiates between normal, ischemic and infarct tissues.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: January 17, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Mitsue Miyazaki, Xiangzhi Zhou, Tsutomu Hoshino
  • Patent number: 9523753
    Abstract: Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse (50). MR signals are acquired at an inversion time (TI) after the IR radio frequency pulse. TI is selected such that a first tissue of interest (e.g., blood) exhibits negative magnetism excited by the IR radio frequency pulse and a second tissue (e.g., intraplaque hemorrhage tissue) exhibits positive magnetism excited by the IR radio frequency pulse. The acquired magnetic resonance signals are reconstructed to generate spatial pixels or voxels wherein positive pixel or voxel values indicate spatial locations of positive magnetism and negative pixel or voxel values indicates spatial locations of negative magnetism. A first image (28) representative of the first tissue is generated from spatial pixels or voxels having negative signal intensities, and a second image (26) representative of the second tissue is generated from spatial pixels or voxels having positive signal intensities.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: December 20, 2016
    Assignee: Koninklijke Philips N.V.
    Inventors: Jinnan Wang, Michael Günter Helle, William Sean Kerwin, Peter Boernert, Chun Yuan
  • Patent number: 9478009
    Abstract: The disclosure describes a technique for medical imaging, referred to herein as the Rapid Interleave Overlap Technique (RIOT), wherein image data is acquired as a plurality of series sequences in a manner that allows for unlimited overlap. RIOT involves interleaving and overlapping 2D image slices of multiple series of image data of the same ROI into a composite data set from which MPR and 3D reconstructions exhibiting excellent resolution properties and crisp image quality can be generated.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: October 25, 2016
    Inventors: Madelyn Milagros Stazzone, Omar G. El-Ghazzawy, Fred William Prior
  • Patent number: 9468394
    Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 18, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: Youngkyoo Jung
  • Patent number: 9453896
    Abstract: In a method and apparatus for magnetic resonance (MR) imaging, a magnetization of nuclear spins in a subject is prepared in multiple preparation modules of an acquisition sequence. MR signals are acquired with at least one imaging module of the sequence. Spoiler gradient fields are generated in the multiple preparation modules in order to affect a transverse magnetization of the spins. The spoiler gradient fields that are applied in at least two different preparation modules are spatially varied along different directions. Spoiler gradient moments of the spoiler gradient fields are selected so that, for at least one of three orthogonal spatial directions, a weighted sum of the spoiler gradient moments that are applied along this spatial direction satisfies a threshold condition.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: September 27, 2016
    Assignee: Siemens Aktiengesellschaft
    Inventors: Thorsten Feiweier, Bernd Kuehn
  • Patent number: 9408927
    Abstract: The present invention is directed, in part, to compounds and methods for imaging the central nervous system or cancer, comprising administering to a subject a contrast agent which comprises a compound that binds MC-I, and an imaging moiety, and scanning the subject using diagnostic imaging.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: August 9, 2016
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, David S. Casebier, Ming Yu, Mikhail Kagan, Joel Lazewatsky
  • Patent number: 9366154
    Abstract: A method for automated detection of ingestion of at least one foreign body by a gas turbine engine, according to which: instantaneous speed of the rotor is measured; a speed signal of the rotor is filtered to separate a static component from a dynamic component thereof; the filtered dynamic component is compared to a standard resonance wave of the rotor to obtain an ingestion indicator, the standard resonance wave corresponding to the vibrational impulse response of a rotor; the obtained ingestion indicator is compared with a detection threshold; and a foreign body ingestion detection signal is emitted when the ingestion indicator is higher than the detection threshold.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: June 14, 2016
    Assignee: SNECMA
    Inventor: Sebastien Bourget
  • Patent number: 9360539
    Abstract: A system for perfusion and diffusion MR imaging of a portion of patient anatomy includes an RF (Radio Frequency) signal generator for generating RF excitation pulses in anatomy and enabling subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator acquire within a single MR imaging scan, perfusion image data of the 3D volume, at least partially in the presence of contrast agent, and diffusion image data of the 3D volume.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: June 7, 2016
    Assignee: National Institute of Health (NIH), U.S. Dept. Of Health and Human Services (DHHS), U.S. Government
    Inventors: Timothy J Carroll, Yong Jeong, Sumeeth Vijay Jonathan, Parmede Vakil
  • Patent number: 9349199
    Abstract: A method for generating an image of an obtaining a three-dimensional (3D) volume dataset of an object of interest, automatically analyzing the 3D volume dataset to generate a window level setting, automatically generating a window width setting based on the window level setting, and automatically displaying an image of the object of interest using the window width setting. An imaging system and a non-transitory computer readable medium are also described.
    Type: Grant
    Filed: June 26, 2012
    Date of Patent: May 24, 2016
    Assignee: General Electric Company
    Inventors: Guillermo Ruiz, Celine Pruvot, Jean-Marc Treutenaere
  • Patent number: 9301704
    Abstract: A magnetic resonance imaging system uses a first RF coil for acquiring a magnetic resonance signal from a subject, and a device for estimating a cardiac phase of the subject based on the magnetic resonance signal acquired by the first RF coil. The first RF coil, for example, can be an RF coil exclusive to cardiac phase estimation. The magnetic resonance imaging system also uses a second RF coil for acquiring a magnetic resonance signal based on the estimated cardiac phase, and a device for reconstructing a magnetic resonance image of the subject based on the magnetic resonance signal acquired by the second RF coil. Thus, MRA can be performed by estimating a cardiac phase.
    Type: Grant
    Filed: March 25, 2005
    Date of Patent: April 5, 2016
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Hiroshi Takai, Yoshimori Kassai
  • Patent number: 9208557
    Abstract: The invention relate to a system and a process for estimating hemodynamic parameters by applying soft probabilistic methods to perfusion imaging. Such a process also makes it possible to estimate arterial input or complementary distribution functions and therefore more generally any quantity of interest. The invention stands out in particular from the known processes in that it requires the introduction, a priori, of soft information of physiological or hemodynamic nature without constraining of forcing the desired estimation through arbitrary or undesirable hypotheses.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: December 8, 2015
    Assignee: OLEA MEDICAL
    Inventor: Fabrice Pautot
  • Patent number: 9192357
    Abstract: A tissue response in a predetermined unit of volume or area tissue of interest is determined by excluding some data of the adjacent tissues based upon a blood flow direction with respect to the tissue of interest. The exclusion is based upon a predetermined time-related parameter such as time-to-peak and mean-transit time in the fitted curves of the uptake of a contrast agent in the adjacent tissues and the tissue of interest. Furthermore, the blood flow direction is determined in terms of a 3D vector based upon a plurality of weighted individual vectors from the adjacent or neighboring voxels with respect to the voxel of interest.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: November 24, 2015
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Nicolas Rognin
  • Patent number: 9117141
    Abstract: In a method and apparatus for identifying a region of interest in medical imaging data of a subject is described, an intensity projection image is generated from the medical imaging data. The medical imaging data is then processed to find one or more maxima in the medical imaging data. The found maxima are compared with the intensity projection image, and one of the maxima which is not represented in the intensity projection image is identified.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: August 25, 2015
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventor: Matthew David Kelly
  • Patent number: 9101283
    Abstract: In a method and magnetic resonance system to determine a flow coding for a flow measurement with the magnetic resonance system, in order to determine the optimal flow coding, a flow pre-measurement with multiple different flow codings is conducted within a slice within a body to be examined, each of these codings allowing flow velocities to be detected with a sensitivity dependent on the respective coding. A velocity distribution of the non-slice-location-specific flow velocity values is generated from all of the results of this flow pre-measurement by a common Fourier transformation. The optimal flow coding for the flow measurement is then determined based on this velocity distribution.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 11, 2015
    Assignee: Siemens Aktiengesellschaft
    Inventor: Andreas Greiser
  • Patent number: 9095272
    Abstract: In a method to excite a magnetization in the generation of MR angiography images with the TOF technique, a slice plane is determined in which the magnetization for the generation of the MR angiography images should be excited, a position of a vessel in the slice plane is determined, and the magnetization is excited in the slice plane such that the magnetization in the vessel has a flip angle gradient in the direction of the vessel.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: August 4, 2015
    Assignee: Siemens Aktiengesellschaft
    Inventor: Hans-Peter Fautz
  • Patent number: 9042961
    Abstract: Velocity of MR-imaged fluid flows is measured. Data representing a measure of distance traveled by flowing fluid appearing in at least two MR images of a subject's tissue taken at different respective imaging times is generated. Data representing at least one fluid velocity measurement of the flowing fluid is generated by calculating at least one instance of distance traveled by the fluid divided by elapsed time during travel based on different respective imaging times. Data representing at least one fluid velocity measurement is then output to at least one of: (a) a display screen, (b) a non-transitory data storage medium, and (c) a remotely located site.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: May 26, 2015
    Assignees: KABUSHIKI KAISHA TOSHIBA, TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Mitsue Miyazaki
  • Patent number: 9042613
    Abstract: Systems and methods are disclosed for evaluating cardiovascular treatment options for a patient. One method includes creating a three-dimensional model representing a portion of the patient's heart based on patient-specific data regarding a geometry of the patient's heart or vasculature; and for a plurality of treatment options for the patient's heart or vasculature, modifying at least one of the three-dimensional model and a reduced order model based on the three-dimensional model. The method also includes determining, for each of the plurality of treatment options, a value of a blood flow characteristic, by solving at least one of the modified three-dimensional model and the modified reduced order model; and identifying one of the plurality of treatment options that solves a function of at least one of: the determined blood flow characteristics of the patient's heart or vasculature, and one or more costs of each of the plurality of treatment options.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: May 26, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Ryan Spilker, David Eberle, Leo Grady
  • Publication number: 20150141804
    Abstract: Provided herein are methods and apparatuses for determining a level of cellular metabolic activity for a region of interest in order to detect and map on-going gliovascular unit metabolic activity using high-resolution 1H2O MRI. In one example approach, a computer-implemented method includes receiving a first set of DCE-MRI time-course data for a region, wherein a contrast agent is administered prior to imaging, identifying a region of interest from the first set of DCE-MRI time-course data for further analysis, performing shutter-speed pharmacokinetic analysis of the time-course data associated with the region of interest using computer-implemented software to obtain a finite and non-zero mean water molecule capillary lifetime in the region of interest, and indicating a level of cellular metabolic activity in the brain based on the mean water molecule capillary lifetime.
    Type: Application
    Filed: November 17, 2014
    Publication date: May 21, 2015
    Applicant: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: William Rooney, Charles Springer, JR., Xin Li
  • Patent number: 9026191
    Abstract: In a method and device for automatic determination of a flow of a bodily fluid within vessels of an organism by a magnetic resonance, a magnetic resonance angiography to procedure is implemented generate magnetic resonance angiography images, a of magnetic resonance flow measurement is implemented to generate magnetic resonance flow images, and the magnetic resonance angiography images are applied to the magnetic resonance flow images as a mask to produce a resulting image depicting vessels with flow therein.
    Type: Grant
    Filed: February 7, 2008
    Date of Patent: May 5, 2015
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Assmann, Okan Ekinci
  • Patent number: 9014782
    Abstract: Versatility and the quality of images are to be improved. As preparation pulses, a first RF pulse to flip along the yz plane spins oriented in a magnetostatic field direction in a subject; a velocity encoding gradient pulse which, in spins flipped by that first RF pulse, mutually shifts the phase of spins in a static state and the phase of spins in a moving state; and a second RF pulse to flip along the yz plane spins whose phase has been shifted by the velocity encoding gradient pulse are successively transmitted. After that, a killer pulse is transmitted to extinguish the transverse magnetizations of the spins flipped by the second RF pulse.
    Type: Grant
    Filed: December 19, 2006
    Date of Patent: April 21, 2015
    Assignee: GE Medical Systems Global Technology Company, LLC
    Inventor: Mitsuharu Miyoshi
  • Patent number: 9009016
    Abstract: A method for measuring the cerebral perfusion of a living organism (1) by means of magnetic resonance (=“MR”) imaging proposes acquisition of further MR signals in a slice (5) that is pervaded by an artery that supplies the blood to the brain in order to determine the temporal progression of the concentration of the contrast medium during the bolus passage in the artery. During acquisition of the further MR signals, a magnetic field gradient is applied in such a way that projection images of the slice are generated. In each time interval between the excitations of the further MR signals, at least one radio-frequency (=“RF”) pulse is irradiated that causes saturation of the nuclear spin magnetization in the slice. This enables simultaneous measurement of the contrast medium flow in the vessels supplying the brain and the brain tissue within the same sequence with an adapted dynamic range.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: April 14, 2015
    Assignee: Universitaetsklinikum Freiburg
    Inventors: Valerij Kiselev, Elias Kellner
  • Patent number: 8998818
    Abstract: A system for detecting and measuring increased global or local intracranial pressure includes various devices for performing controlled occlusion of jugular cranial blood outflow and generating occlusion data related to said controlled occlusion, a cranial blood outflow pressure measurement device and a processor for processing jugular cranial blood outflow occlusion data and cranial blood outflow data to identify and/or measure a functional relationship between the jugular controlled occlusion and the jugular cranial blood outflow pressure. A device communicates the functional relationship a display device and/or a patient monitoring system. The processor also detects a state of equilibrium between the jugular cranial blood outflow pressure and the jugular occlusion pressure at occlusion.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: April 7, 2015
    Inventors: Henrikas Pranevicius, Mindaugas Pranevicius, Osvaldas Pranevicius, David Liebeskind
  • Patent number: 9002429
    Abstract: For delivery of a chemical to a target region of a subject's brain, an apparatus comprising a storage medium on which is stored digital representations of subject-specific selective visual stimuli that, when viewed, selectively stimulate blood flow to the target area of the brain; and an electronic display device coupled thereto and configured for converting the stored digital representations to images viewable by the subject; wherein the one or more selective visual stimuli were determined by exposing the subject to a plurality of potential stimuli; measuring the blood flow response to multiple regions of the brain, including the target area and one or more non-target areas; comparing the blood flow responses to the potential stimuli, and selecting as selective stimuli potential stimuli that result in relatively more blood flow to the target area and relatively less blood flow one or more non-target areas.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: April 7, 2015
    Assignee: Texas Instruments Incorporated
    Inventor: Leonardo W. Estevez
  • Patent number: 9002690
    Abstract: Embodiments include a system for providing blood flow information for a patient. The system may include at least one computer system including a touchscreen. The at least one computer system may be configured to display, on the touchscreen, a three-dimensional model representing at least a portion of an anatomical structure of the patient based on patient-specific data. The at least one computer system may also be configured to receive a first input relating to a first location on the touchscreen indicated by at least one pointing object controlled by a user, and the first location on the touchscreen may indicate a first location on the displayed three-dimensional model. The at least one computer system may be further configured to display first information on the touchscreen, and the first information may indicate a blood flow characteristic at the first location.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: April 7, 2015
    Assignee: HeartFlow, Inc.
    Inventors: Gregory R. Hart, John H. Stevens
  • Patent number: 9002430
    Abstract: A method for performing magnetic resonance angiography and perfusion imaging using the same pulse sequence is provided. Time-resolved image data is acquired as a contrast agent passes through a subject. This image data is acquired by sampling Cartesian points in k-space that are contained within either a central region of k-space, or one of a plurality of different sets of radial sectors extending outwards from the central region. The image data is combined to form individual image frame data sets that are then reconstructed to produce a time series of image frames. From this time series, MR angiograms and perfusion maps are produced. With the added acquisition of calibration data, T1 relaxation parameters are estimated and quantitative perfusion maps produced.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: April 7, 2015
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Stephen J Riederer, Norbert G Campeau, Clifton R Haider
  • Publication number: 20150094563
    Abstract: A magnetic resonance system configured to repeatedly execute imaging sequences each having a first RF pulse for flipping each spin in a region containing blood, and a data acquisition sequence acquiring data of the blood from the region is provided. The magnetic resonance system includes a storage unit configured to store a correspondence relation between a contrast between the blood and a background tissue, a first time taken from the first RF pulse to the data acquisition sequence, and a second time taken from a completion of an imaging sequence to a start of a next imaging sequence, first determining means configured to determine the first time used, and second determining means configured to determine the second time used.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Applicant: GE MEDICAL SYSTEMS GLOBAL TECHNOLOGY COMPANY, LLC
    Inventors: Yuko Suwa, Naoyuki Takei
  • Publication number: 20150087967
    Abstract: Provided herein is a Magnetic Resonance Imaging (MRI) technique and, optionally, software, collectively referred to as the “shutter-speed” model, to analyze image data of cancer patients. Embodiments provide a minimally invasive, yet precisely accurate, approach to determining whether tumors are malignant or benign by distinguishing the characteristics of contrast reagent activity in benign and malignant tumors. Exemplary embodiments provide MRI measured biomarkers for tumor malignancy determination and monitoring, effectively eliminating or limiting the false positives suffered by existing MRI techniques while also improving tissue phenotyping and therapeutic intervention monitoring and prediction.
    Type: Application
    Filed: April 22, 2013
    Publication date: March 26, 2015
    Inventors: Charles S. Springer, Jr., Wei Huang, Xin Li, William D. Rooney, Jr., Ian J. Tagge, James A. Balschi, Yajie Zhang
  • Publication number: 20150080707
    Abstract: A method includes obtaining contrast enhanced perfusion imaging data of at least two vessel regions, one downstream from the other, and at least one tissue of interest, which receives blood from the circulatory system, of a scanned subject. The method further includes determining a blood flow time difference between contrast material peaks of the at least two vessel regions based on the image data. The method further includes determining an absolute perfusion of the tissue of interest based on the image data. The method further includes computing a standardized perfusion value based on the absolute perfusion and the time difference. The method further includes displaying the standardized perfusion value.
    Type: Application
    Filed: April 10, 2013
    Publication date: March 19, 2015
    Inventors: Raz Carmi, Galit Sarit Kafri
  • Patent number: 8983570
    Abstract: The invention relates to methods for the diagnosis, amelioration, and treatment of back pain, particularly lumbar back pain, in particular, back pain caused by muscular abnormalities, vertebral body osteoporosis, and disc degeneration. Patients with back pain are categorized into specific subsets that are deemed to have potential to respond to therapy. In particular, the invention includes a therapy involving stimulation of neovascularization so as to increase perfusion of various spine compartments.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: March 17, 2015
    Assignee: Cardiovascular Biotherapeutics, Inc.
    Inventors: Thomas J. Stegmann, Kenneth A. Thomas, John W. Jacobs, Tugan Muftuler, Shadfar Bahri, Hon Yu, Vance Gardner