Using Detectable Material Placed In Body Patents (Class 600/420)
  • Patent number: 11366186
    Abstract: Systems and methods are provided for producing hyperpolarized materials for use during a magnetic resonance imaging (MRI) or nuclear magnetic resonance (NMR) process. The system and methods include the use of microfluidic and/or microreactor methods in one or more of the stages of parahydrogen production, enriched substrate production, and spin order transfer from the parahydrogen to a substrate.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: June 21, 2022
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: David Alsop, Aaron Grant
  • Patent number: 11364002
    Abstract: A medical-image processing apparatus and a medical-image diagnostic apparatus according to an embodiment include an acquisition unit, a generation unit, an identification unit, and a display control unit. The acquisition unit acquires a medical image containing a blood vessel collected by the medical-image diagnostic apparatus. The generation unit generates an anatomical structure model based on the medical image acquired by the acquisition unit. The identification unit identifies a position, on the medical image, of an index relating to blood flow analyzed through fluid analysis using the anatomical structure model. The display control unit displays the position of the index on the medical image, and also displays the index associated with the position of the index on the medical image.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: June 21, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Satoshi Wakai, Takuya Sakaguchi, Akihito Takahashi
  • Patent number: 11366190
    Abstract: An exemplary system, method and computer-accessible medium for characterizing a microstructure of a prostate of a patient can be provided, which can include, for example, generating a magnetic resonance (MR) radiofrequency (RF) pulse(s) by varying (i) a diffusion time, (ii) a diffusion gradient direction, (iii) a diffusion gradient pulse width, or (iv) a diffusion gradient pulse shape, applying the MR RF pulse(s) to the prostate of the patient, receiving a resultant MR signal from the prostate of the patient that can be based on the MR RF pulse(s), determining information regarding a plurality of compartments for the prostate from the resultant MR signal by varying an echo time or a mixing time, and characterizing the microstructure for each of the compartments by applying a microstructural model(s) to each of the compartments.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: June 21, 2022
    Assignee: New York University
    Inventors: Dmitry Novikov, Els Fieremans, Gregory Lemberskiy
  • Patent number: 11337665
    Abstract: Contrast agents for x-ray imaging including stabilized metal nanoparticles and encapsulated nanoparticles, as well as methods for imaging tissue with these agents, are disclosed. Also disclosed are methods of dual energy x-ray imaging using metal nanoparticle contrast agents or encapsulated metal nanoparticles.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 24, 2022
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Andrew D. A. Maidment, Anatoliy V. Popov, E. James Delikatny, Andrew Tsourkas, Roshan Karunamuni, Ajlan Al Zaki, Sara Gavenonis, David Cormode
  • Patent number: 11330999
    Abstract: The present technology provides 13C- and 15N-labeled probes for imaging one or more mammalian cells using magnetic resonance. Thus, 13C- and 15N-labeled arginine (compound of formula I), xanthine (compounds of formula II and formula III), urea (compounds of formula IV), and glutamine (compounds of formula V), stereoisomers, tautomers, and pharmaceutically acceptable salts thereof are provided. Further methods of making the labelled probes and methods of using the probes to detect arginase, xanthine oxidase, and glutaminase metabolites and activity are provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: May 17, 2022
    Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER
    Inventors: Andrew Cho, Roozbeh Eskandari, Valentina Di Gialleonardo, Kayvan R. Keshari
  • Patent number: 11320507
    Abstract: A nuclear magnetic resonance apparatus (100) includes: a static magnetic field former (10) that forms a static magnetic field; an object holder (2) that holds an object in the static magnetic field; a pulse applicator (51a) that applies ?/2 pulse having the Larmor frequency of an atom to be measured to the object in the static magnetic field, and then applies a ? pulse having the Larmor frequency to the object at least a predetermined number of times (the predetermined number being two or more) at an interval of the predetermined period, the ? pulse being applied for a first time at a time point at which half the predetermined period has elapsed after applying the ?/2 pulse; and a detector (40) that detects the signal intensity of a spin echo signal generated from the object as a result of the last instance of the predetermined number of times of application of the ? pulse.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: May 3, 2022
    Assignee: NIIGATA UNIVERSITY
    Inventor: Susumu Sasaki
  • Patent number: 11294016
    Abstract: A method for correcting concomitant gradient field effects in a magnetic resonance imaging (MRI) system includes determining a plurality of first phase difference measurements between two acquisitions using a plurality of first bipolar gradient waveforms applied to a first gradient coil. A first gradient coil constant is determined based on the plurality of first phase difference measurements and compensatory gradient waveforms are determined based on the first gradient coil constant. The compensatory gradient waveforms are applied to the gradient coils along with target gradient waveforms to compensate for a concomitant gradient field.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: April 5, 2022
    Assignee: GE Precision Healthcare LLC
    Inventors: Thomas K. F. Foo, Louis M. Frigo
  • Patent number: 11250628
    Abstract: There is provided a method for geometrical reconstruction of an internal anatomical structure using at least one processor based on a set of contours derived from the internal anatomical structure, the set of contours including a first subset of long-axis contours obtained based on a first set of long-axis images of the internal anatomical structure. The method includes: adjusting the set of contours, comprising adjusting the first subset of long-axis contours to correct for motion artefacts in the first set of long-axis images; and deforming a template three-dimensional (3D) surface mesh preconfigured for the internal anatomical structure's type into a deformed 3D surface mesh based on the adjusted set of contours to obtain the geometrical reconstruction of the internal anatomical structure. In particular, the internal anatomical structure is a heart. There is also provided a corresponding system for geometrical reconstruction of an internal anatomical structure.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: February 15, 2022
    Assignees: Agency for Science, Technology and Research, Singapore Health Services Pte Ltd
    Inventors: Yi Su, Soo Kng Teo, Xiaodan Zhao, Liang Zhong, Ru San Tan
  • Patent number: 11252345
    Abstract: Provided are a dual-spectrum camera system based on a single sensor and an image processing method. The camera system includes a lens, an image sensor, and a logical light separation module and an image fusion module that are sequentially connected to the image sensor. The image sensor includes red-green-blue (RGB) photosensitive cells and infrared radiation (IR) photosensitive cells. An infrared cut-off filter layer is arranged on a light incoming path of the RGB photosensitive cells. The image sensor receives incident light entering through the lens to generate an original image and sends the original image to the logical light separation module. The logical light separation module converts and separates the original image into a visible light image and an infrared image, and sends the visible light image and the infrared image to the image fusion module to generate a fused image.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: February 15, 2022
    Assignee: ZHEJIANG UNIVIEW TECHNOLOGIES CO., LTD
    Inventors: Yue Sun, Duoming Chen, Hengle Yu
  • Patent number: 11224394
    Abstract: The invention relates to an apparatus configured to display an aortic valve image and an indicator when the aortic valve is in its open-state and/or when the valve is in its closed-state. The indicator is supposed to be in an overlay to the image of the aortic valve, such that a physician can see on the same display image the information needed to advance a guide wire or catheter through the aortic valve of a heart. This may prevent damaging ensures not to damage the aortic valve. The physician receives the relevant information, when the aortic valve is in its open-state and thus being in a state to be passed by the catheter. The information, whether the aortic valve is in its open-state or in its closed-state, corresponds to the systolic phase and the distal phase of the heart, respectively. The information, when the heart is in its systolic phase and when it is in the diastolic phase may be extracted from an ECG measurement.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: January 18, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dirk Schaefer, Cherif Sahyoun, Eberhard Sebastian Hansis, Christian Haase, Tobias Klinder, Michael Grass
  • Patent number: 11226387
    Abstract: Provided is a new scheme for applying a CS technology in a technology for imaging a target tissue based on a difference from a reference image or a control image. In this way, an imaging time is shortened. A measurement unit of an MRI apparatus executes a first imaging sequence and a second imaging sequence having different contrasts for a target, and measures a nuclear magnetic resonance signal from a subject in each of the imaging sequences. In the second imaging sequence, under-sampling is performed, and a nuclear magnetic resonance signal having a small number of samples is measured. The image processing unit restores measurement data including a nuclear magnetic resonance signal obtained by under-sampling using compressed sensing. At this time, data restoration including a term for minimizing an L1 norm is performed for a difference image between an image obtained by execution of the first imaging sequence and an image obtained by execution of the second imaging sequence.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: January 18, 2022
    Assignee: HITACHI, LTD.
    Inventor: Kousuke Itou
  • Patent number: 11211166
    Abstract: Example embodiments are described that relate to the analysis of tissue damage in an injured patient. Example embodiments are methods and systems for collecting medical imaging data, identifying tissue damage in the medical imaging data, analyzing the tissue damage shown in the medical imaging data, and/or quantifying the tissue damage shown in the medical imaging data. The disclosed methods allow for determining a risk for multiple organ failure and systemic inflammation in a multiply injured patient.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: December 28, 2021
    Assignee: Indiana University Research & Technology Corp
    Inventors: Todd O. McKinley, Scott D. Steenburg
  • Patent number: 11199602
    Abstract: Methods and systems for acquiring a visualization of a target. For example, a computer-implemented method for acquiring a visualization of a target includes: generating a first sampling mask; acquiring first k-space data of the target at a first phase using the first sampling mask; generating a first image of the target based at least in part on the first k-space data; generating a second sampling mask using a model based on at least one selected from the first sampling mask, the first k-space data, and the first image; acquiring second k-space data of the target at a second phase using the second sampling mask; and generating a second image of the target based at least in part on the second k-space data.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: December 14, 2021
    Assignee: Shanghai United Imaging Intelligence Co., Ltd.
    Inventors: Zhang Chen, Shanhui Sun, Terrence Chen
  • Patent number: 11179140
    Abstract: A treatment device includes a unit having an ultrasound imaging element and an ablation electrode, mechanism for receiving signals from the imaging element, the signals representing plural frames of ultrasound data; and mechanism for processing the signals to provide, in use, at least one of ultrasound data and data indicating mechanical strains within tissue being monitored by the sensor element, the strains being generated by movement of the tissue or the body being treated, the movement being generated naturally by the tissue or by the device operator's motion, or both.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: November 23, 2021
    Inventors: Paul Mark Galluzzo, William Henry Gomersall, Mikhail Evgen'evich Bashtanov
  • Patent number: 11160992
    Abstract: A light emitting type capsule treatment tool for irradiating light with a specific wavelength required for photoimmunotherapy, includes a power receiving coil, a magnetic member, a light emitting member and a capsule. The power receiving coil is formed by winding a conductive wire and configured to receive electric power supplied from an external transmission antenna via a magnetic flux. The magnetic member is placed on an inner circumference of the power receiving coil. The light emitting member is configured to be supplied with electric power from the power receiving coil and to emit the light with the specific wavelength. The capsule houses the power receiving coil, the magnetic member and the light emitting member.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: November 2, 2021
    Assignees: PIOLAX, INC., PIOLAX MEDICAL DEVICES, INC., B & PLUS K.K.
    Inventors: Toshihiro Kimura, Satoshi Yoshita, Yasuo Yoshikawa, Takayuki Shindo
  • Patent number: 11156684
    Abstract: Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: October 26, 2021
    Assignees: Duke University, Vanderbilt University, Board of Trustees of Southern Illinois University
    Inventors: Warren S. Warren, Thomas Theis, Eduard Y. Chekmenev, Milton L. Truong, Aaron M. Coffey, Boyd Goodson, Fan Shi, Roman V. Shchepin
  • Patent number: 11112477
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a sequence controller and a storage unit. The sequence controller acquires magnetic resonance signals of a target imaging part including cerebrospinal fluid flowing therein of a subject in a condition where a supply of oxygen is receivable, at a plurality of time phases in an oxygen inhalation process of the subject. The storage unit stores therein the magnetic resonance signals acquired at the time phases.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: September 7, 2021
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventors: Yasutaka Fushimi, Naotaka Sakashita
  • Patent number: 11079454
    Abstract: Systems and methods are provided for performing automated reconstruction of a dynamic MRI dataset that is acquired without a fixed temporal resolution. On one or more image quality metrics (IQMs) are obtained by processing a subset of the acquired dataset. In one example implementation, at each stage of an iterative process, one or more IQMs of the image subset is computed, and the parameters controlling the reconstruction and/or the strategy for data combination are adjusted to provide an improved or optimal image reconstruction. Once the IQM of the image subset satisfies acceptance criteria based on an estimate of the overall temporal fidelity of the reconstruction, the full reconstruction can be performed, and the estimate of the overall temporal fidelity can be reported based on the IQM at the final iteration.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 3, 2021
    Assignee: NOVA SCOTIA HEALTH AUTHORITY
    Inventors: James Rioux, Nathan Murtha, Steven Beyea
  • Patent number: 11026648
    Abstract: Visualization of a region of interest and planning a location of at least one injection point for a medical procedure is provided. At least one volume of imaging data for a region of interest is received. At least one virtual injection point is obtained. The at least one injection point indicates a location in a network of blood vessels for at least one injection. First and second rendering modules are controlled to construct a combined volume presentation including a first volume region rendered by a first rendering module at a relatively low level of detail and a second volume region is rendered at a higher level of detail by a second rendering module. The first and second volume regions are designated based on the at least one virtual injection point.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 8, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Pieter Maria Mielekamp, William Edward Peter Van Der Sterren
  • Patent number: 11024024
    Abstract: Systems and methods for analyzing perfusion-weighted medical imaging using deep neural networks are provided. In some aspects, a method includes receiving perfusion-weighted imaging data acquired from a subject using a magnetic resonance (“MR”) imaging system and modeling at least one voxel associated with the perfusion-weighted imaging data using a four-dimensional (“4D”) convolutional neural network. The method also includes extracting spatio-temporal features for each modeled voxel and estimating at least one perfusion parameter for each modeled voxel based on the extracted spatio-temporal features. The method further includes generating a report using the at least one perfusion parameter indicating perfusion in the subject.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: June 1, 2021
    Assignee: The Regents of the University of California
    Inventors: Corey Arnold, King Chung Ho, Fabien Scalzo
  • Patent number: 11002810
    Abstract: A passive magnetic flux focusing element having electrically conductive wires (1) or faces (2) containing an outer area defined by an outer (3), an inner (4) and connecting edges (5) forming a closed current loop enclosing a surface area penetrated by a time varying magnetic field flux and through induction sets up a time varying electrical current in the conducting loop thereby achieving a counter magnetic field to the penetrating field completely canceling the penetrating field in the interior of the loop, is characterized in that the element is part of an RF volume- or surface-coil arrangement adapted for receiving and/or transmitting RF signals. Such elements increase the sensitivity and the SNR in MRI and MR spectroscopy experiments due to an increased magnetic flux density by means of Lenz lenses, in combination with a conventional probe.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: May 11, 2021
    Assignee: Voxalytic GmbH
    Inventors: Joerg Funk, Peter While, Nils Spengler, Jan Korvink
  • Patent number: 10980978
    Abstract: In some examples, a burr hole cap assembly includes one or more markers that indicate a rotational orientation of a therapy delivery member relative to the burr hole cap assembly, where the therapy delivery member extends through an opening defined by the burr hole cap assembly. In addition, in some examples, the burr hole cap assembly includes a feature that indicates the rotational orientation of the therapy delivery member after the therapy delivery member is implanted in the patient. The feature can include the one or more markers in some examples.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: April 20, 2021
    Assignee: MEDTRONIC, INC.
    Inventors: Steven M. Goetz, Mark J. Holle, Ashish Singal, Spencer Fodness-Bondhus
  • Patent number: 10955496
    Abstract: Gas vesicle protein structures and related compositions, methods, and systems for singleplexed and/or multiplexed magnetic resonance imaging of a target site alone or in combination with ultrasound are described, in which the gas vesicle protein structures provide contrast for the imaging.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: March 23, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: George J. Lu, Mikhail G. Shapiro, Arash Farhadi, Jerzy O. Szablowski
  • Patent number: 10939876
    Abstract: A magnetic resonance (MR) system (10) for guidance of a shaft or needle (16) to a target (14) of a subject (12) is provided. The system includes a user interface (76). The user interface (76) includes a frame (78) positioned on a surface of the subject (12). The frame (78) includes an opening (82) over an entry point of a planned trajectory for the shaft or needle (16). The planned trajectory extends from the entry point to the target (14). The user interface (76) further includes one or more visual indicators (80) arranged on the frame (78) around the opening (82). The one or more visual indicators (80) at least one of: 1) visually indicate deviation of the shaft or needle (16) from the planned trajectory; and 2) visually indicate a current position of a real-time slice of real-time MR images.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: March 9, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Steffen Weiss, Thomas Erik Amthor, Sascha Krueger, Daniel Wirtz, Falk Uhlemann
  • Patent number: 10928475
    Abstract: A method for providing magnetic resonance imaging with dynamic contrast and 4D flow of a volume of an object in a magnetic resonance imaging (MRI) system is provided. Contrast agent is provided to the volume of the object. Magnetic resonance excitation from the MRI system is applied to the volume of the object. The MRI system reads out a subsample of less than 10% of spatially resolved data and velocity encoded data with respect to time. The readout subsample is used to determine both dynamic contrast and 4D flow.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: February 23, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Joseph Y. Cheng, Tao Zhang, John M. Pauly, Shreyas S. Vasanawala
  • Patent number: 10925565
    Abstract: A method comprises: inputting contrast enhancement data for at least one organ of a patient, at least one patient attribute of the patient, and a test bolus data or bolus tracking data to a regressor; receiving a contrast agent administration protocol from the regressor, based on the contrast enhancement data, the at least one patient attribute and the test bolus or bolus tracking data; and injecting a contrast agent into the patient according to the received contrast agent administration protocol.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: February 23, 2021
    Assignee: Siemens Healthcare GmbH
    Inventors: Pooyan Sahbaee Bagherzadeh, Saikiran Rapaka
  • Patent number: 10908235
    Abstract: A method of spatially imaging a nuclear magnetic resonance (NMR)parameter whose measurement requires the acquisition of spatially localized NMR signals in a sample includes placing the sample in an MRI apparatus with a plurality of MRI detectors each having a spatial sensitivity map; and applying MRI sequences adjusted to be sensitive to the NMR parameter. At least one of the MRI sequences is adjusted so as to substantially fully sample an image k-space of the sample. The remainder of the MRI sequences is adjusted to under-sample the image k-space. The method further includes acquiring image k-space NMR signal datasets; estimating a sensitivity map of each of the MRI detectors using a strategy to suppress unfolding artefacts; and applying the estimated sensitivity maps to at least one of the image k-space NMR signal data sets to reconstruct a spatial image of NMR signals that are sensitive to the NMR parameter.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: February 2, 2021
    Assignee: The Johns Hopkins University
    Inventors: Yi Zhang, Jinyuan Zhou, Paul A. Bottomley
  • Patent number: 10901058
    Abstract: CEST imaging technique and MR scanning are used as an MRI method for detecting levels of lactate in vivo by exploiting the exchange of —OH protons on lactate with bulk water. In accordance with this method, one first obtains a lactate CEST MRI map of a slice of the body of a patient. A contrast agent such as pyruvate, glucose or glutamine is administered and a post-administration CEST MRI map is obtained. The difference in the spatial maps indicates the level of expression of lactate in the tissue of interest.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: January 26, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Ravinder Reddy, Hari Hariharan, Catherine DeBrosse, Ravi Prakash Reddy Nanga, Puneet Bagga
  • Patent number: 10895621
    Abstract: Systems and methods are disclosed for a simultaneous 3D T1 and B1+ mapping technique based on VFA imaging using a reference region VFA (RR-VFA) approach to eliminate the need for a separate B1+ mapping scan while imaging the prostate. The RR-VFA method assumes the existence of a “reference region” that is distributed throughout the volume of interest and is well characterized by a known T1 relaxation time. In particular, fat is generally selected as the reference region due to its distribution in the body. B1+ inhomogeneity is estimated in the fat tissue and interpolated over the entire volume of interest, thus eliminating the need for an additional scan.
    Type: Grant
    Filed: October 29, 2018
    Date of Patent: January 19, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kyung Sung, Holden Wu, Novena Rangwala
  • Patent number: 10849528
    Abstract: An exemplary system, method and computer-accessible medium for determining an arterial input function (AIF) of a mammal(s) can be provided, which can include, for example, receiving information related to a global circulatory system of the mammal(s), and determining the AIF based on the information by modeling a blood flow in the global circulatory system of the mammal(s) in terms of an input response function(s). The input response function(s) can include a delayed input response function(s). In certain exemplary embodiments of the present disclosure, the input response function(s) can include at least three input response functions, and each of the input response functions can be from a different part of a body of the mammal(s). The AIF can be determined by coupling the input response functions. The AIF can be further determined based on a total tracer amount in an organ(s) of the mammal(s).
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: December 1, 2020
    Assignee: New York University
    Inventors: Dmitry Novikov, Jerian Jahani, Valeriji G. Kiselev
  • Patent number: 10842746
    Abstract: Disclosed herein are methods for producing bi-directionally crosslinked liposomes. The methods include the steps of: providing a lipid composition comprising a plurality of reactive lipids, wherein each of the reactive lipids comprises a reactive hydrophobic group, a reactive hydrophilic group, or a reactive hydrophilic group and a reactive hydrophobic group; forming an un-crosslinked liposome comprising the reactive lipids; and crosslinking at least a portion of the reactive hydrophobic groups or the reactive hydrophilic groups; thereby producing the bi-directionally crosslinked liposomes. Bi-directionally crosslinked liposomes and methods for delivering therapeutic and/or diagnostic agents to subjects using the liposomes are also described.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: November 24, 2020
    Assignee: Verily Life Sciences LLC
    Inventors: Kimberly Kam, Zhan Wang, Stephen Morton
  • Patent number: 10810740
    Abstract: A system and method for automated characterization of solid tumors using medical imaging. The system comprises an interface that is configured to acquire data from medical imaging devices, one or more processors, and an outputting device that reports the characterization of said solid tumor. The method of automated characterization, which is implemented by the system, acquires a sequence of images from the medical imager using a Dynamic Contrast Enhanced (DCE) imaging protocol, performs image registration, detects the contour of the solid tumor, and dividing the contours to segments. For each segment, the method calculating a displacement of the contrast material, fitting the displacement to a flow model and extracting an estimation of the interstitial fluid velocity.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: October 20, 2020
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Maya Dadiani, Arnaldo Mayer, Miriam Sklair-Levy
  • Patent number: 10791957
    Abstract: An open MRI methodology and system that allows dynamic viewing and access to a patient. In intraoperative MRI, the MRI apparatus is configured in the shape of a typical operating room, with full 360° access to the patient. The MRI apparatus encompasses the entire operating room with magnets located on or near the ceiling and floor of the operating room. The remainder of the MRI apparatus, including the control computer, and imaging monitor, may be located outside of the MRI operating room, in order to keep the operating room free of unnecessary equipment, or located inside of the MRI operating room, as desired for operability of the MRI. The patient is placed over the magnet in the floor, the only fixed location in the operating room. The operating room may contain typical operating equipment, as needed, such as cardiopulmonary bypass units, surgical navigation systems, endoscopy systems, and anesthesia carts.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: October 6, 2020
    Assignee: FONAR Corporation
    Inventor: Raymond V. Damadian
  • Patent number: 10775452
    Abstract: A Magnetic Particle Imaging (MPI) system with a magnet configured to generate a magnetic field having a field free line, the system including at least one shim magnet configured to modify the magnetic field in a manner to maintain desired magnetic flux distributions during imaging.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: September 15, 2020
    Assignees: MAGNETIC INSIGHT, INC., UNIVERSITY OF CALIFORNIA AT BERKELEY
    Inventor: Patrick W. Goodwill
  • Patent number: 10751431
    Abstract: Multi-modal imaging capsule for image-guided proton beam therapy, consisting of a biocompatible polymer layer, 18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: August 25, 2020
    Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center
    Inventor: Mamdooh Alqathami
  • Patent number: 10744091
    Abstract: The disclosure relates to a layer comprising at least one hydrophilic part and at least one hydrophobic part, the layer comprising self-assembled amphiphilic molecules polymerized with each other on both the hydrophilic part and the hydrophobic part of the layer; a detecting device comprising a substrate and the above-mentioned layer; and a liposome, a micelle, transport system for a substance and a biomimetic system comprising the above-mentioned layer. The disclosure also relates to a process for producing a layer, the process comprising: providing amphiphilic molecules; allowing sufficient time for the amphiphilic molecules to self-assemble and form at least one hydrophilic part and at least one hydrophobic part of the layer; polymerizing the self-assembled amphiphilic molecules with each other on both the hydrophilic part and the hydrophobic part of the layer.
    Type: Grant
    Filed: October 13, 2016
    Date of Patent: August 18, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Université d'Aix-Marseille
    Inventors: Ahmad Kenaan, Anne Magali Charrier, Sébastien Lavandier, Jean-Manuel Raimundo
  • Patent number: 10733734
    Abstract: An image analysis apparatus includes a processor including hardware. The processor extracts parts from each of a first image and a second image acquired after the first image, each of the extracted parts including an annular peripheral portion and a central portion having a color different from a color of the peripheral portion. The processor also sets the central portion as the analysis object region and calculates a brightness decrease degree of the analysis object region in the second image relative to the analysis object region in the first image.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: August 4, 2020
    Assignee: OLYMPUS CORPORATION
    Inventors: Tetsuhiro Yamada, Momoko Yamanashi, Toshio Nakamura, Ryuichi Toyama
  • Patent number: 10687785
    Abstract: Systems and methods for detecting electromechanical wave propagation within a body structure of a patient in a series of image frames representing movement the body structure are provided. Image data is acquired comprising a series of image frames corresponding to the movement of a body structure. A correlation calculation is performed on the image frames to generate a displacement map representing the relative displacement between the first and second image frames. A video is generated comprising a series of displacement maps. The parameters of movement of the body structure are detected by analysis of the displacement maps. The image acquisition can detect the movement of the body structure without inducing such movement.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: June 23, 2020
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERISTY IN THE CITY OF NEW YORK
    Inventors: Elisa E. Konofagou, Jean Provost
  • Patent number: 10677874
    Abstract: A system and method is provided to acquire images of a subject having received a tissue soluble hyperpolarized gas into the airways. The method includes performing a pulse sequence including (i) for each effective repetition time (TReff), acquiring at least one gas-phase dataset and at least one dissolved-phase dataset, wherein a gas-phase echo time (TEGas) of the at least one gas-phase dataset and a dissolved-phase echo time (TEDissolved) of the at least one dissolved-phase dataset are selected to isolate gas-phase contamination of the dissolved-phase dataset from dissolved-phase components in the dissolved-phase dataset.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: June 9, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Sean Fain, Andrew Hahn, Jeffrey Kammerman
  • Patent number: 10667760
    Abstract: In a method and magnetic resonance (MR) apparatus for heart diffusion imaging, when an ECG trigger signal by a computer that operates an MR scanner, the MR scanner is operated to acquire a navigator echo before a stimulated echo sequence, in order to detect diaphragm position information. When the first diaphragm position information is not located in an acquisition window, the stimulated echo sequence is not executed, and the computer waits to receive the next ECG trigger signal. The detection time of the navigator echo after the stimulated echo sequence as well as the acquisition time of the stimulated echo sequence, are thus eliminated when the first diaphragm position information does not meet requirements, so can significantly reduce scanning time, and increase the image SNR.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: June 2, 2020
    Assignee: Siemens Healthcare GmbH
    Inventors: Jing An, Fang Dong, Zhi Guo Sun, Yu Yu Wang, Qiong Zhang
  • Patent number: 10649044
    Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: May 12, 2020
    Assignee: UNIVERSITÄT ULM
    Inventors: Fedor Jelezko, Martin Plenio, Ilai Schwartz, Qiong Chen, Alex Retzker
  • Patent number: 10617821
    Abstract: It may desirable to monitor or control a pump remotely. For example, the pump may be positioned near the patient, with remote control or monitoring of the pump occurring in a control room. In one exemplary embodiment, the pump is used in an MRI environment. In another exemplary embodiment, the pump is used in a hyperbaric chamber. The pump may monitor one or more physiological parameters and transmit them to the remote. The pump may also transmit information relating to the pump's operation. The pump may send the device and/or physiological data using one or more packets. The packets may consist of low priority sequential packets and high-priority asynchronous packets. The high-priority packets may enable the real-time monitoring of a patient's heart beat or other physiological parameter.
    Type: Grant
    Filed: January 4, 2018
    Date of Patent: April 14, 2020
    Assignee: IRADIMED CORPORATION
    Inventor: Roger E. Susi
  • Patent number: 10613178
    Abstract: In one embodiment, an MRI apparatus includes: a scanner equipped with at least a static magnetic field magnet configured to generate a static magnetic field, a gradient coil configured to apply gradient pulses, and an RF coil configured to apply RF pulses to an object and receive magnetic resonance signals from the object; and processing circuitry configured to set at least one pulse sequence which includes a labeling pulse for labeling fluid in the object, an excitation pulse applied after the labeling pulse, and a bipolar or unipolar velocity encoding gradient pulse for encoding velocity information of the fluid, and generate an image of the fluid from the magnetic resonance signals which the scanner acquires by performing the at least one pulse sequence.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: April 7, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Tokunori Kimura, Naotaka Sakashita
  • Patent number: 10596210
    Abstract: A monocyte, monocyte derived cell or macrophage infected with an oncolytic herpes simplex virus is disclosed together with uses of such infected cells in the treatment of diseases such as cancer.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: March 24, 2020
    Assignees: Virttu Biologics, The university of Sheffield
    Inventors: Joe Conner, Munitta Muthana, Claire Elizabeth Lewis
  • Patent number: 10583209
    Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2?-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: March 10, 2020
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Mathilde H. Lerche, Pernille Rose Jensen, Magnus Karlsson, Roberta Napolitano, Claudia Cabella, Luigi Miragoli, Sonia Colombo Serra, Fabio Tedoldi
  • Patent number: 10543312
    Abstract: A fluid delivery system includes a pressurizing mechanism. The pressurizing mechanism includes: a substantially cylindrical body having a movable member positioned therein that divides the body into a first chamber and a second chamber; a plunger rod connected to a first side of the movable member and extending through a substantially closed first end of the body; and an elongated member connected to a second side of the movable member and extending through a substantially closed second end of the body. The plunger rod configured to operatively engage a fluid container. Fluid is dispensed from the fluid container by forming a vacuum within at least the first chamber by moving the movable member toward the second end of the body, allowing atmospheric pressure to enter the second chamber, and actuating the pressurizing mechanism to cause the moving member to move towards the first end of the body.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: January 28, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventor: Kevin P. Cowan
  • Patent number: 10527689
    Abstract: A system and method for system for performing a magnetic resonance imaging (MRI) process using an MRI system is provided. A coil system includes a substrate configured to follow a contour of a portion of a subject to be imaged by the MRI system and at least one coil coupled to the substrate and forming a spiral pattern.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 7, 2020
    Assignee: The General Hospital Corporation
    Inventors: Matthew S. Rosen, Mathieu Sarracanie, Najat Salameh
  • Patent number: 10517556
    Abstract: A method for increasing the temporal fidelity, increasing the temporal sampling density, and/or reducing the temporal noise of a series of image frames obtained with a medical imaging system is provided. The image frames are acquired with the medical imaging system. The medical imaging system may be, for example, an x-ray C-arm imaging system. A window function that is representative of a temporal fidelity window is selected and used to temporally deconvolve the image frames using a minimization technique. A temporal sampling density may also be selected and used in the temporal deconvolution. The resultant deconvolved image frames have a higher temporal fidelity to a time-varying image contrast depicted in the acquired image frames, and may also have an increased temporal sampling density and/or reduced temporal noise.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: December 31, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Guang-Hong Chen, Jie Tang
  • Patent number: 10492710
    Abstract: The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: December 3, 2019
    Assignee: Case Western Reserve University
    Inventors: Charlie Y. Wang, Mark A. Griswold, Xin Yu
  • Patent number: 10426375
    Abstract: The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 1, 2019
    Assignee: The Regents of the University of California
    Inventors: Krystof S. Bankiewicz, Kathryn H. Rosenbluth, Adrian P. Kells