Using Detectable Material Placed In Body Patents (Class 600/420)
  • Patent number: 10353040
    Abstract: Described here are systems and methods for obtaining measurements of both tissue perfusion and permeability with a magnetic resonance imaging (“MRI”) system after the administration of a single dose of contrast agent. To this end, the MRI system is directed to acquire T2-weighted or T2*-weighted data, during which the acquired signal values are monitored for a trigger event. When the trigger event occurs, the MRI system is directed to switch from acquiring the T2-weighted or T2*-weighted data to acquiring T1-weighted data. The systems and methods described here can thus be used for a fully automated, single acquisition of perfusion and permeability measurements using only a single dose of contrast agent.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: July 16, 2019
    Assignee: Northwestern University
    Inventors: Todd Parrish, Yu Fen Chen
  • Patent number: 10349919
    Abstract: Provided is an ultrasound diagnosis apparatus including a data acquirer configured to obtain ultrasound data about an object having blood vessels; an image processor configured to extract a blood vessel area from an ultrasound image generated based on the ultrasound data, extract a plaque area included in the blood vessel area, and analyze a risk of plaque based on at least one of a surface shape of the plaque area and brightness information of the plaque area; and a display configured to display the risk of plaque.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: July 16, 2019
    Assignee: SAMSUNG MEDISON CO., LTD.
    Inventors: Jin-ki Park, Jin-yong Lee, Hyuk-jae Chang, Namsik Chung, Geu-ru Hong, Chi-young Shim, Ji-hyun Yoon, In-jeong Cho, Ran Heo
  • Patent number: 10302720
    Abstract: In a method and apparatus for determining time-dependent dephasing factors of at least one spectral component of at least two spectral components in a region of interest in an object under examination, measured data of the region of interest and acquired over time by a test measurement in a magnetic resonance scanner. The contribution of at least one of the at least two spectral components in the recorded measured data is determined. Dephasing factors of the at least one spectral component are determined on the basis of the contribution determined therefor in the recorded measured data over time. Dephasing factors determined in this way can be determined individually with relatively little effort and used in Dixon techniques.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: May 28, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Stephan Kannengiesser, Marcel Dominik Nickel
  • Patent number: 10299683
    Abstract: A method for differentiation of normal myocardium from diffuse disease using T mapping includes acquiring one or more images of a patient by an imaging apparatus, generating a T1 map from the one or more images, defining a region of interest within the one or more images, determining the average T1 value within the region of interest, comparing the average T1 value within the region of interest to a cut-off T1 value, and determining a diagnosis of the region of interest from the comparison.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: May 28, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Tobias Ratko Voigt, Andrea Jane Wiethoff, Tobias Richard Schaeffter, Eike Caspar Cornelius Nagel, Valentina Otja Puntmann
  • Patent number: 10288706
    Abstract: In a method and apparatus for magnetic resonance (MR) fingerprinting, an MR signal is acquired from a subject by radiating radio-frequency (RF) energy that produces an RF transmission field that has a localized amplitude in the subject. The RF energy is radiated with an RF pulse configuration that maps the localized RF field amplitude in the phase of the MR signal from the subject. The detected MR signal is compared to a source of stored MR signal physical or theoretical models that respectively map different localized RF transmission field information in the respective phase thereof, the stored models being respectively for different substances. A substance in the subject from which the detected MR signal curve originated is identified by comparing the detected MR signal curve to the stored models to identify a best match.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: May 14, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Thorsten Feiweier, Gregor Koerzdoerfer, Mathias Nittka
  • Patent number: 10278585
    Abstract: A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: May 7, 2019
    Assignee: NOVADAQ TECHNOLOGIES ULC
    Inventors: T. Bruce Ferguson, Jr., Cheng Chen
  • Patent number: 10267882
    Abstract: An MR image especially useful for computer-guided diagnostics uses at least one programmed computer to acquire an MR-image of T1 values for a patient volume containing at least one predetermined tissue type having a respectively corresponding predetermined range of expected T1 values. A color-coded T1-image is generated from the MR-image by (a) assigning a first color or spectrum of colors to those pixels having a T1 value falling within a predetermined range of expected T1 values and (b) assigning a second color or spectrum of colors to those pixels having a T1 value falling outside a predetermined range of expected T1 values. The color-coded T1-image is then displayed for use in computer-aided diagnosis of patient tissue.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: April 23, 2019
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventor: Mitsue Miyazaki
  • Patent number: 10265421
    Abstract: The invention relates to a method of Magnetic Resonance (MR) detection, in particular 13C-MR detection, by using a diagnostic medium comprising a hyperpolarized ester, in particular ethyl acetoacetate. The method comprises the detection of the MR signal of a hyperpolarized 13C carboxylic ester and of its respective hyperpolarized metabolite.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: April 23, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Pernille Rose Jensen, Lerche H. Mathilde, Magnus Karlsson, Claudia Cabella, Sonia Colombo Serra, Luigi Miragoli, Luca Venturi, Fabio Tedoldi
  • Patent number: 10254368
    Abstract: A system and method for acquiring magnetic resonance imaging (MRI) images with an MRI system is provided. The system and method directs the MRI system first to produce an inversion recovery radio frequency (RF) pulse, wait for a time period, produce a T2-preparation RF pulse, wait for another time period, and then acquire data of a part of a subject. The first produced RF pulse rotates net magnetization 180 degrees about an axis. The pulse sequence used to acquire data can be any two-dimensional or three-dimensional sequence used to acquire a volume in the subject. The two waiting time periods are chosen such that the signals of two or more tissues of the subject are nulled.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: April 9, 2019
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Tamer Basha, Reza Nezafat
  • Patent number: 10251578
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: April 9, 2019
    Assignees: NOCIMED, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
  • Patent number: 10226178
    Abstract: Apparatus and methods are described, including, using an imaging device, acquiring a plurality of images of a portion of a body of a subject. Using a processor, a first feature within each of the images is aligned. At least one enhanced image that is enhanced with respect to the first feature is generated, using the aligned images. Visibility of a second feature is reduced in the enhanced image, and the at least one image that is enhanced with respect to the first feature is displayed upon a display. Other applications are also described.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: March 12, 2019
    Assignee: SYNC-RX LTD.
    Inventors: Ran Cohen, Eldad Klaiman, Alexander Steinberg, Sagiv Philipp, David Tolkowsky
  • Patent number: 10185890
    Abstract: In a method and computer for evaluating medical image data of an examination subject, a clinical marker of the examination subject is acquired that characterizes a status of the examination subject in relation to a physiological parameter, and a normal value range for the physiological parameter is ascertained that is matched to the status of the examination subject as a function of the clinical marker. Medical image data of the examination subject are acquired, and a value of the physiological parameter of the examination subject is determined using the medical image data. This value is compared with the normal value range matched to the status of the examination subject, and the result of the comparison is provided as an output.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: January 22, 2019
    Assignee: Siemens Healthcare GmbH
    Inventors: Thorsten Feiweier, Oliver Patrick Welzel
  • Patent number: 10159454
    Abstract: An imaging system selects a medical imaging protocol using a repository of information associating multiple ranges of contrast agent peak time with corresponding different imaging protocols. An imaging protocol comprises a method for acquiring images using an imaging system and using data identifying at least one of (a) an imaging rate within an imaging scan cycle and (b) an interval between imaging scans. A contrast agent peak time comprises a time a contrast agent concentration substantially reaches a peak value in an anatomical region of interest of a patient relative to a time of start of contrast agent injection. A contrast agent peak time detector detects a contrast agent peak time. An imaging processor adaptively selects an imaging protocol from the imaging protocols in response to a comparison of a detected contrast agent peak time with at least one of the plurality of ranges.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: December 25, 2018
    Assignee: Siemens Healthcare GmbH
    Inventors: Katharine Lynn Rowley Grant, Bernhard Schmidt
  • Patent number: 10147207
    Abstract: A system and method for reconstructing an image using a cone-beam computed tomography (CT) imaging system includes acquiring data from a subject with the CT imaging system using a limited scan range that is less than 360 degrees. The process also includes reconstructing at least one image of the subject having a first temporal resolution from the data acquired, performing a temporal deconvolution of the at least one image using a finite temporal window to generate at least one image of the subject with a second temporal resolution that is greater than the first temporal resolution, and subtracting the at least one image of the subject with the second temporal resolution and a mask image of the subject to generate a time-resolved CT angiogram of the subject.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: December 4, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Guang-Hong Chen, Charles Strother
  • Patent number: 10147314
    Abstract: Example apparatus and methods provide improved spatial and temporal resolution over conventional magnetic resonance renography (MRR). Example apparatus and methods reconstruct under-sampled three-dimensional (3D) data associated with nuclear magnetic resonance (NMR) signals acquired from a kidney. The data is reconstructed using a 3D through-time non-Cartesian generalized auto-calibrating partially parallel acquisitions (GRAPPA) approach. Example apparatus and methods produce a quantized value for a contrast agent concentration in the kidney from a signal intensity in the data based, at least in part, on a two compartment model of the kidney. The two compartment model includes a plasma compartment and a tubular compartment. The quantized value describes a perfusion parameter for the kidney or a filtration parameter for the kidney.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 4, 2018
    Assignee: Case Western Reserve University
    Inventors: Vikas Gulani, Katherine Wright, Nicole Seiberlich, Mark Griswold
  • Patent number: 10117886
    Abstract: A delivery system comprising an organic nanoparticle, a hyaluronidase anchored or conjugated to the organic nanoparticle. The organic nanoparticle may be selected from a polymer-based nanoparticle, a lipid-based nanoparticle and nanoparticle formed by lipid-like molecules. In some embodiments, the hyaluronidase is covalently bound to a linker or spacer which, in turn, is anchored or covalently bound to the organic nanoparticle. The delivery system may also comprise an active pharmaceutical agent, a diagnostic agent, and/or a cellular membrane. The organic nanoparticle may further have a low density poly(ethylene glycol) layer on the surface. Methods for using the delivery system including for treating or diagnosing a disease are also provided. The organic nanoparticle provides enhanced diffusion/penetration through the extracellular matrix found in tumors, as well as increased circulation time in a human or animal body.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: November 6, 2018
    Inventors: Hao Cheng, Hao Zhou
  • Patent number: 10083505
    Abstract: In a magnetic resonance method and apparatus for determination of a measurement variable that is relevant to a function of an organ of a patient, a first longitudinal relaxation rate R11 is determined before a contrast medium is administered to the patient. A second longitudinal relaxation rate R12 is determined after a contrast medium is administered to the patient. A property of the contrast medium in the organ is determined based on R11 and R12. The measurement variable is determined based on the property of the contrast medium in the organ.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: September 25, 2018
    Assignee: Siemens Healthcare GmbH
    Inventors: Stephan Kannengiesser, Berthold Kiefer, Marcel Dominik Nickel
  • Patent number: 10080536
    Abstract: A device and method are provided for supplying a medium to an object of interest, such as a patient to be scanned for image acquisition. The device comprises an arc-shaped member and a support for said arc-shaped member, wherein the arc-shaped member is configured to support a radiation source on one end and a detector on another end to scan the object of interest, and the support comprises a gantry with a rotatable support arm supporting the arc-shaped member. The device further comprises at least one medium supply unit mounted on the gantry. The supply unit is connectable to a cable that is guided in the vicinity or in the region of the axis of rotation of the support arm so that the object of interest can be supplied with a perfusion or any other medium, while enabling the mobile imaging device to rotate around the patient to acquire x-ray images.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: September 25, 2018
    Assignee: General Electric Company
    Inventor: Paul Vincent Margot
  • Patent number: 10084042
    Abstract: A population of bright and stable nanocrystals is provided. The nanocrystals include a semiconductor core and a thick semiconductor shell and can exhibit high extinction coefficients, high quantum yields, and limited or no detectable blinking.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: September 25, 2018
    Assignee: Life Technologies Corporation
    Inventors: Eric Welch, Joseph Bartel, Eric Tulsky, Joseph Treadway, Yongfen Chen
  • Patent number: 9980692
    Abstract: A system 100 for enabling interactive annotation of an image 102, comprising a user input 160 for receiving a placement command 162 from a user, the placement command being indicative of a first placement location of a marker 140 in the image 102, and a processor 180 arranged for (i) applying an image processing algorithm to a region 130 in the image, the region being based on the first placement location, and the image processing algorithm being responsive to image portions which visually correspond to the marker 140 for establishing a plurality of match degrees between, on the one hand, the marker, and, on the other hand, a plurality of image portions within the region, (ii) establishing a second placement location in dependence on the plurality of match degrees and the respective plurality of image portions for matching the marker 140 to the region in the image, and (iii) placing the marker 140 at the second placement location in the image 102.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: May 29, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Thomas Buelow, Kirsten Regina Meetz, Martin Bergtholdt
  • Patent number: 9956304
    Abstract: Provided is a protein contrast agent for enhancing an MRI image and comprising a polypeptide having a conformation presenting at least five oxygen atoms positioned to chelate at least one paramagnetic metal ion such as Gd3+, each oxygen atom being between about 2 angstrom units and about 5 angstrom units from the metal ion; the metal ion has at least one water molecule electrostatically interacting a distance of less than about 10 angstrom units a target-specific moiety conjugated thereto, at least one polyethylene glycol molecule, and a paramagnetic metal ion. Also provided is a method of obtaining an enhanced MRI image using the protein contrast agent to a T2/T1 or T1/T2 intensity ratio of the MRI image; and (d) obtaining an image of the T2/T1 or T1/T2 intensity ratio.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: May 1, 2018
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Jenny Jie Yang, Zhiren Liu, Shunyi Li, Yubin Zhou, Jie Jiang, Shenghui Xue, Jingjuan Qiao, Lixia Wei
  • Patent number: 9953439
    Abstract: Some aspects of the present disclosure relate to systems and methods for three-dimensional spiral perfusion imaging. In one embodiment, a method for perfusion imaging of a subject includes acquiring perfusion imaging data associated with the heart of a subject. The acquiring includes applying an imaging pulse sequence with a three-dimensional stack-of-spirals trajectory. The method also includes reconstructing perfusion images from the acquired perfusion imaging data. The reconstructing includes parallel imaging and motion-guided compressed sensing. The method also includes determining, from the reconstructed perfusion images, absolute perfusion values based on time-intensity relationships to quantify myocardial blood flow of the heart of the subject, and generating a quantitative volumetric perfusion flow map based on the determined absolute perfusion values.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: April 24, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: Michael Salerno, Craig H. Meyer, Xiao Chen, Yang Yang, Frederick H. Epstein, Christopher M. Kramer
  • Patent number: 9931082
    Abstract: A system and method for cardiac magnetic resonance imaging (MRI) is disclosed that facilitates the phase sensitive reconstruction of inversion recovery magnetization prepared data with minimal scan time penalty by acquiring the phase reference data with low spatial resolution. The technique can be applied for the investigation of myocardial tissue characterization by acquiring 2D and/or 3D late Gadolinium enhancement (LGE) scans after the injection of a Gadolinium contrast agent. Regional areas of contrast accumulation in scarred myocardial tissue appear bright on these T1-weighted images. As disclosed here the proposed technique for phase sensitive inversion recovery acquisition with low resolution phase reference is robust against changes in inversion time, change in T1 due to Gadolinium contrast washout, high signal-to-noise ratio, and low scan time penalty compared to magnitude LGE.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: April 3, 2018
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Martin Andreas Janich, Thomas Kwok-Fah Foo, Anja Christina Sophie Brau
  • Patent number: 9901730
    Abstract: This stopcock flow path switching device includes: a three-way stopcock having a flow path switching cock and provided to, by switching of the flow path switching cock, allow flow path switching between a state in which a contrast agent introducing flow path is formed by coupling a flow path on the patient side to a flow path on the injector head side and a state in which a blood pressure measuring flow path is formed by coupling the flow path on the patient side to a flow path on the blood pressure transducer side; and a clamp mechanism for closing the flow path of the three-way stopcock communicating with the injector head side, in the state in which the blood pressure measuring flow path is formed.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: February 27, 2018
    Assignee: SUGAN CO., LTD.
    Inventor: Tetsuya Yamamoto
  • Patent number: 9821090
    Abstract: The present disclosure relates generally to coating medical devices. In particular, the present disclosure provides materials and methods for coating a portion of a balloon catheter with a pharmaceutical agent using electrodeposition techniques. Although angioplasty and stenting can be effective methods for treating vascular occlusions, restenosis remains a pervasiveness problem. Therefore, coating portions of a balloon catheter with a pharmaceutical agent that inhibits restenosis can reduce the likelihood of restenosis.
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: November 21, 2017
    Assignee: The Spectranetics Corporation
    Inventor: Thomas Kelby Triffo
  • Patent number: 9795693
    Abstract: Described are drug carriers useful in magnetic resonance imaging (MRI)-guided drug release comprising a shell capable of releasing an enclosed biologically active agent as a result of a local stimulus, e.g. energy input, such as heat, wherein the shell encloses a 19F MR contrast agent. Preferably, the carrier also acts as a contrast enhancement agent for MRI based on the principle of Chemical Exchange-dependent Saturation Transfer (CEST). To this end the shell encloses a cavity that comprises a paramagnetic chemical shift reagent, a pool of proton analytes, and the 19F contrast agent, and wherein the shell allows diffusion of the proton analytes.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: October 24, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Sander Langereis, Jochen Keupp, Holger Gruell, Dirk Burdinski, Danielle Beelen
  • Patent number: 9791533
    Abstract: A magnetic resonance imaging apparatus according to an embodiment includes an execution unit and a generation unit. The execution unit executes first data collection after a predetermined inversion time elapses from a time when a labeling pulse is applied to a fluid flowing into an imaging region of a subject and a second data collection without application of the labeling pulse. The generation unit generates a differential image by using the first data and the second data. Here, the generation unit generates the differential image by a different differential method according to a relationship between the inversion time and a longitudinal relaxation time of the fluid.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: October 17, 2017
    Assignee: TOSHIBA MEDICAL SYSTEMS CORPORATION
    Inventors: Naotaka Sakashita, Tokunori Kimura
  • Patent number: 9770223
    Abstract: A system and method for reconstructing a series of images of a subject includes acquiring medical image data from the subject with a medical imaging system and reconstructing a series of images of the subject from the acquired medical image data set. The reconstructing includes enforcing general adherence to a non-patient-specific signal model that describes a dependency of image intensity values on at least one variable that is associated with a physical or physiological property by constraining reconstruction of individual images in the series of images using the non-patient-specific model. The reconstructing also includes preserving information in the series of images that deviate from the non-patient-specific model by controlling a requirement of consistency with the non-patient-specific model.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: September 26, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Alexey A. Samsonov, Julia V. Velikina
  • Patent number: 9766313
    Abstract: The invention relates to a method of CEST or APT MR imaging of at least a portion of a body (10) placed in a main magnetic field B0 within the examination volume of a MR device. The method of the invention comprises the following steps: •a) subjecting the portion of the body (10) to a saturation RF pulse at a saturation frequency offset; •b) subjecting the portion of the body (10) to an imaging sequence comprising at least one excitation/refocusing RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body (10) as spin echo signals; •c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; •d) reconstructing a MR image and/or B0 field homogeneity corrected APT/CEST images from the acquired MR signals.
    Type: Grant
    Filed: March 21, 2013
    Date of Patent: September 19, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Eggers, Jochen Keupp
  • Patent number: 9741112
    Abstract: A method for generating an image-based test improves diagnostic accuracy by iteratively modifying rule sets governing image and data analysis of coregistered image tiles. Digital images of stained tissue slices are divided into tiles, and tiles from different images are coregistered. First image objects are linked to selected pixels of the tiles. First numerical data is generated by measuring the first objects. Each pixel of a heat map aggregates first numerical data from coregistered tiles. Second objects are linked to selected pixels of the heat map. Measuring the second objects generates second numerical data. The method improves how well second numerical data correlates with clinical data of the patient whose tissue is analyzed by modifying the rule sets used to generate the first and second objects and the first and second numerical data. The test is defined by those rule sets that produce the best correlation with the clinical data.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 22, 2017
    Assignee: Definiens AG
    Inventors: Ralf Schoenmeyer, Gerd Binnig, Guenter Schmidt
  • Patent number: 9714995
    Abstract: The present disclosure provides various methods and systems for performing magnetic resonance studies. In accordance with many embodiments, image or other information of interest is derived from super radiant pulses. In various illustrative methods, beneficial agents can be administered to samples or subjects to be studied. Some beneficial agents can include biomarkers, or precursors to biomarkers.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: July 25, 2017
    Assignee: Millikelvin Technologies LLC
    Inventor: Neil Kalechofsky
  • Patent number: 9702953
    Abstract: A method of sampling in pure phase encode MRI including restricting sampled points to a specified region.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: July 11, 2017
    Assignee: University of New Brunswick
    Inventors: Dan Xiao, Bruce Balcom
  • Patent number: 9700229
    Abstract: A method of producing a series of vasculature images over an extended field of view (FOV) larger than an FOV of an MRI system includes acquiring initial time-resolved image data from the vasculature and, during the acquiring process, reconstructing, in substantially real-time, a series of three-dimensional (3D) tracking images of the initial portion of the vasculature illustrating a current position of a contrast bolus in the vasculature as the contrast bolus passes through the initial portion of the vasculature. Based on a current position of the contrast bolus, the subject is moved to a subsequent imaging station to acquire subsequent time-resolved image data and reconstruct subsequent 3D tracking images of subsequent portions of the vasculature. This process is repeated and then an image is assembled that extends over the extended FOV using the initial time-resolved image data and the subsequent time-resolved image data.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: July 11, 2017
    Assignee: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Stephen J. Riederer, Casey P. Johnson
  • Patent number: 9658300
    Abstract: Hyperpolarized samples (i.e., samples having fractional spin polarization P of at least 0.1) of a target molecular species are created through spin transfer from hyperpolarized xenon atoms or other source isotopes. Reversible nanoscale solid state contact is achieved between the hyperpolarized xenon atoms and molecules of a target species. The resulting solid state mixture is exposed to conditions of magnetic field and temperature designed to allow or even facilitate transfer of spin polarization from the xenon to the target molecules. The xenon and the target species are then separated under conditions that substantially preserve the polarization of the target species. The hyperpolarized target species can then be introduced into a subject of a nuclear magnetic resonance (NMR) experiment.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: May 23, 2017
    Assignee: California Institute of Technology
    Inventor: Daniel P. Weitekamp
  • Patent number: 9619880
    Abstract: The invention improves the quality of image diagnosis by a user. An image processing unit compares each pixel value of a perfusion image with a threshold, and extracts a lesion candidate region as a collateral circulation candidate or bypass blood vessel candidate from the perfusion image based on a comparison result. The image processing unit displays the lesion candidate region together with a blood vessel image representing the spatial distribution of blood vessels in a head.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: April 11, 2017
    Assignee: Toshiba Medical Systems Corporation
    Inventor: Yoshihiro Ikeda
  • Patent number: 9619904
    Abstract: A method for reconstructing high signal-to-noise ratio (SNR) magnetic resonance imaging (MRI) slices, including: receiving a thick MRI slice of bodily tissue acquired using a single MRI scan, wherein the thick slice has a high SNR; receiving two thin MRI slices of the bodily tissue acquired using a single MRI scan, wherein each of the two thin MRI slices has a low SNR; and reconstructing multiple high SNR thin slices of the bodily tissue using the thick slice and the two thin slices.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: April 11, 2017
    Assignees: Technion Research & Development Foundation Limited, The Medical Research, Infrastructure and Health Services Fund of the Tel-Aviv Medical Center
    Inventors: Lior Weizman, Yonina Eldar, Dafna Ben Bashat
  • Patent number: 9566381
    Abstract: A disposable fluid connector includes a first single-use tubing component having proximal and distal ends and a second single-use tubing component having proximal and distal ends, where the first single-use tubing component and the second single-use tubing component are each usable only for a single patient procedure. The disposable fluid connector also includes a connection comprising an electrical connector that is configured to electrically connect the connection to both a powered injector and to an external medical device, where the disposable fluid connector comprises a disposable cassette including a portion that is non-removably attached to both the first single-use tubing component and the second single-use tubing component.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 14, 2017
    Assignee: ACIST Medical Systems, Inc.
    Inventors: Traci Barron, Niels Clausen-Stuck, Mark Fisher, Joseph Graceffa, David J. Hajicek, Martin G. Hieb, Anastasios G. Karahalios, Karen Kensok, Robert Kim, Lawrence Lunzer, Manfred Maiers, Adolfo Menendez, Jr., Khader Mohiuddin, Richard A. Oftedahl, Volker Roos, Jeremiah O'Leary
  • Patent number: 9465094
    Abstract: A method is disclosed for the automated classification of an image property of a magnetic resonance image. In an embodiment, the method includes determining at least the parameters T, T2 and proton density of at least two tissues imaged in the magnetic resonance image or prespecifying at least two sets of at least these parameters; calculating the signal intensity in the center of the k-space for each imaged tissue or each set of parameters; and classifying the image property as a function of the calculated signal intensities. A magnetic resonance device is also disclosed.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: October 11, 2016
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventor: Thorsten Feiweier
  • Patent number: 9445722
    Abstract: A method is disclosed for performing a combined magnetic resonance/positron emission tomography scan of an examination object in an MR/PET system. An embodiment of the method entails acquiring first magnetic resonance data using a first readout gradient field. The first readout gradient field is chosen such that, at a location of the field of view of the magnetic resonance system, a distortion caused by a nonlinearity of the first readout gradient field and a distortion caused by a B0 field inhomogeneity substantially cancel each other out. First magnetic resonance images for planning the combined magnetic resonance/positron emission tomography session and determining an attenuation correction map for a positron emission tomography scan are determined on the basis of the first magnetic resonance data. Positron emission data and second magnetic resonance data are acquired using a second readout gradient field.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: September 20, 2016
    Assignee: SIEMENS AKTIENGESELLSCHAFT
    Inventors: Jan Ole Blumhagen, Matthias Fenchel, Ralf Ladebeck
  • Patent number: 9433392
    Abstract: According to one embodiment, a medical image processing apparatus includes an image data acquisition part, a range setting part and a blood vessel image generation part. The image data acquisition part receives one of X-ray contrast image and subtraction image, of an imaging region including blood vessels of an object. The subtraction image are generated by subtraction processing between the X-ray contrast image and non-contrast X-ray image. The range setting part sets a target range in the X-ray contrast image or subtraction image. The blood vessel image generation part derives time changes in concentrations of a contrast agent based on the X-ray contrast image or subtraction image, and generates blood vessel image having pixel values corresponding to times, at which concentrations of the contrast agent become a specific condition, within the target range and pixel values corresponding to concentrations of the contrast agent outside the target range.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 6, 2016
    Assignee: Toshiba Medical Systems Corporation
    Inventor: Satoru Ohishi
  • Patent number: 9423475
    Abstract: An elongate electrical lead assembly that reduces localized heating due to MR scanner-induced currents includes a first elongate electrical lead having a series of alternating single layer coil sections and multi-layer coil sections, a second elongate electrical lead having a series of alternating single layer coil sections and multi-layer coil sections, and a third elongate electrical lead having a coiled section that coaxially surrounds the first and second electrical leads. Each multi-layer coil section of the second electrical lead is coiled around a respective single layer coil section of the first electrical lead, and each single layer coil section of the second electrical lead is coiled around a respective multi-layer coil section of the first electrical lead.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: August 23, 2016
    Assignee: MRI Interventions, Inc.
    Inventors: Parag Karmarkar, Rajesh Pandey
  • Patent number: 9392959
    Abstract: An MR Spectroscopy (MRS) system and approach is provided for diagnosing painful and non-painful discs in chronic, severe low back pain patients (DDD-MRS). A DDD-MRS pulse sequence generates and acquires DDD-MRS spectra within intervertebral disc nuclei for later signal processing & diagnostic analysis. An interfacing DDD-MRS signal processor receives output signals of the DDD-MRS spectra acquired and is configured to optimize signal-to-noise ratio (SNR) by an automated system that selectively conducts optimal channel selection, phase and frequency correction, and frame editing as appropriate for a given acquisition series. A diagnostic processor calculates a diagnostic value for the disc based upon a weighted factor set of criteria that uses MRS data extracted from the acquired and processed MRS spectra along regions associated with multiple chemicals that have been correlated to painful vs. non-painful discs.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: July 19, 2016
    Assignees: Nocimed, Inc., The Regents of the University of California
    Inventors: James Clayton Peacock, III, John Patrick Claude, Paul Henry Kane, Jeffrey C. Lotz
  • Patent number: 9380999
    Abstract: According to one embodiment, there is provided an ultrasonic diagnostic apparatus includes a data acquisition unit configured to scan a three-dimensional region in a subject having a contrast agent injected therein over a predetermined period by using ultrasonic waves and to thereby acquire ultrasonic data concerning the three-dimensional region over the predetermined period, a volume data generation unit configured to generate first volume data in each time phase in an analysis period by using the ultrasonic data concerning the three-dimensional region over the analysis period in the predetermined period and to generate second volume data indicative of contrast agent temporal information about the analysis period and third volume data indicative of a contrast agent characteristic amount at each position in the three-dimensional region in the analysis period, and an image generation unit configured to generate a projected image by using the second volume data and the third volume data.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: July 5, 2016
    Assignees: KABUSHIKI KAISHA TOSHIBA, Toshiba Medical Systems Corporation
    Inventors: Tetsuya Yoshida, Itsuki Kuga
  • Patent number: 9329245
    Abstract: A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high ? nuclei with a short T1, a polarizing agent with a broad EPR line, and low ? nuclei with a long T1. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B0?4.0 T, thus polarizing the high ? nuclei by DNP, and the polarization is transferred from the high ? nuclei to the low ? nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low ? nuclei from the target material. Nuclei with a long longitudinal relaxation time T1 can thereby be quickly hyperpolarized to a high polarization level.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: May 3, 2016
    Assignees: Bruker BioSpin AG, Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Sami Jannin, Antonio Giuseppe Gianotti, Joost Lohman, Frank Engelke, Roberto Melzi, Aurélien Bornet, Geoffrey Bodenhausen
  • Patent number: 9295775
    Abstract: The invention relates to a medical device for injecting contrast media including at least two separate vessels and immiscible contents inside one and/or both of the vessels, an injector and a distributor arranged such as to establish alternating communication between said vessels and said injector, said medical device being characterised in that it includes a means for providing said alternating communication at a frequency of 0.2 to 5 Hz.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: March 29, 2016
    Assignee: BRACCO INJENEERING S.A.
    Inventors: Hervé Duffour, Frédéric Neftel
  • Patent number: 9289265
    Abstract: A magnetic resonance imaging (MRI) compatible sensor for measuring torque with respect to an axis of rotation in conjunction with an applied linear force includes a shaft arranged in a longitudinal direction substantially along the axis of rotation, a base component arranged along the axis of rotation and displaced with respect to the shaft, a torque detector assembly configured to be coupled to rotational motion of the shaft about the axis of rotation relative to the base component, and a linear-force detector assembly configured to be coupled to linear motion of the shaft from a force applied in a direction substantially coincident with the axis of rotation relative to the base component. The torque detector assembly and the linear-force detector assembly are substantially de-coupled from each other such that torque measurements are substantially independent of linear force measurements. The MRI compatible sensor consists essentially of MRI compatible materials.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: March 22, 2016
    Assignee: The Johns Hopkins University
    Inventors: Reza Monfaredi, Iulian Ioan Iordachita, Reza Seifabadi
  • Patent number: 9271661
    Abstract: A method for free-breathing magnetic resonance imaging (MRI) using iterative image-based respiratory motion correction is provided. An MRI system is used to acquired k-space data and navigator data from a subject. The k-space data is then sorted into a plurality of data bins using the navigator data. A motion correction parameter is estimated for each data bin and is applied to the respective k-space data in that bin. The corrected k-space data segments are then combined to form a corrected k-space data set, from which an image is reconstructed. The process may be iteratively repeated until an image quality metric is optimized; for example, until an image sharpness measure is sufficiently maximized.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: March 1, 2016
    Assignee: BETH ISRAEL DEACONESS MEDICAL CENTER, INC
    Inventors: Mehdi Hedjazi Moghari, Reza Nezafat
  • Patent number: 9222995
    Abstract: A dispenser is provided for producing a nuclear hyperpolarized contrast agent. The dispenser comprises a chamber to receive a compound. A photonic hyperpolarization system generates an OAM-photonic beam endowed with orbital angular momentum and is arranged to direct the OAM-photonic beam into the chamber so as to generate nuclear hyperpolarization in the compound. The chamber has an output over which the hyperpolarized compound can be issued. Since the hyperpolarization is generated ex-vivo, the penetration depth of the OAM-photonic beam in biological tissue is irrelevant for the present invention.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: December 29, 2015
    Assignee: Koninklijke Philips N.V.
    Inventor: Johan Samuel Van Den Brink
  • Patent number: 9207296
    Abstract: The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 8, 2015
    Assignee: Huntington Medical Research Institutes
    Inventors: Pratip Bhattacharya, Brian D. Ross
  • Patent number: 9179859
    Abstract: One object of the present invention is to perform compartmental analysis of the dynamics of a tracer in the brain, and the present invention provides a compartmental analysis system including a measurement apparatus that measures the strength of an electromagnetic wave from a tracer and a compartmental analyzer that performs compartmental analysis of the dynamics of the tracer in the brain on the basis of the strength of the electromagnetic wave, wherein the compartmental analyzer includes a rate constant calculation unit that calculates a rate constant when the tracer moves between compartments on the basis of the strength of an electromagnetic wave in a first compartment corresponding to the cerebral blood vessel in the brain or an input function in the first compartment, the strength of an electromagnetic wave in a second compartment corresponding to the brain tissue in the brain, and the strength of an electromagnetic wave in a third compartment corresponding to the cerebral sulcus or cerebral ventricle i
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: November 10, 2015
    Assignee: TAIYO NIPPON SANSO CORPORATION
    Inventors: Akihiko Maeda, Takashi Kambe, Takeshi Ochi