Abstract: A method for imaging includes scanning a B scan of a sample N times at a first slice of a sample. N is greater than or equal to 2. The B scan includes a plurality of A scans. A pixel of the first slice has an M number of A scans within the pixel. Each of the A scans have a spectrum range less than a full spectrum range of the light source. A number of pixels per B scan is an approximate B scan length divided by a lateral resolution size of the pixel. The method further includes determine a flow image of the sample using an optical coherence tomography (OCT) signal reflected back from the sample.

Abstract: A method for image guided surgery includes obtaining intraoperative locations including intraoperative fiducial locations for a non-rigid structure and intraoperative rigid structure locations for associated rigid structures, estimating a gravity deformation for the non-rigid structure based on a first rigid registration for preoperative fiducial locations in a computer model relative to the intraoperative fiducial locations and a second rigid registration for the preoperative rigid structure locations for a rigid structure in the computer model with respect to the intraoperative rigid structure locations, modifying the preoperative fiducial locations using first rigid registration and the gravity deformation, determining a third rigid registration for the modified fiducial locations relative to the intraoperative fiducial locations, calculating a non-rigid transformation for the computer model using the volumetric gravity field deformation and first boundary conditions from errors in the third rigid registra

Abstract: An image generating apparatus includes an obtaining unit configured to obtain plural pieces of tomographic image data, in which each piece of tomographic image data indicates a cross section of substantially the same position of a subject, a calculation unit configured to calculate a motion contrast value based on the plural pieces of tomographic image data and a comparison result of a representative value of the plural pieces of tomographic image data indicating a signal intensity and a threshold, a generation unit configured to generate a motion contrast image of the subject based on the motion contrast value, and a change unit configured to change the threshold.

Abstract: A data processing method performed by a computer for monitoring the position of a patient, comprising the steps of: acquiring a 3D image dataset of the patient; acquiring an initial real image of the patient from a medical imaging system having a known and fixed location in space, thus defining a known viewing direction of the initial real image in space, the real image being taken at a first point in time; —performing 2D/3D registration by calculating a simulated image from the 3D image dataset which matches the initial real image best, the simulated image having a viewing direction onto the 3D image dataset; storing an initial similarity measure value for the pair of the initial real image and the calculated simulated image; —acquiring a subsequent real image from the medical imaging system taken at a second point in time later than the first point in time; calculating a subsequent similarity measure value for the pair of the subsequent real image and the calculated simulated image; and outputting an indica

Abstract: A reflection-mode multispectral photoacoustic microscopy (PAM) system and related method is disclosed, based on an optical-acoustic objective in communication with an ultrasonic transducer. In some embodiments of the disclosed technology, when aligned and positioned in a predetermined manner, little to no chromatic aberration is provided, and with convenient confocal alignment of the optical excitation and acoustic detection.

Abstract: A method of visualizing spinal nerves includes receiving a 3D image volume depicting a spinal cord and a plurality of spinal nerves. For each spinal nerve, a 2D spinal nerve image is generated by defining a surface within the 3D volume comprising the spinal nerve. The surface is curved such that it passes through the spinal cord while encompassing the spinal nerve. Then, the 2D spinal nerve images are generated based on voxels on the surface included in the 3D volume. A visualization of the 2D spinal images is presented in a graphical user interface that allows each 2D spinal image to be viewed simultaneously.

Abstract: A method of generating a patient-specific prosthesis includes receiving anatomic imaging data representative of a portion of a patient's anatomy. A first digital representation of the anatomic imaging data is defined. The first digital representation of the anatomic imaging data is modified. A second digital representation of the portion of the patient's anatomy is defined based on the modifying of the first digital representation of the anatomic imaging data. A patient-specific prosthesis is generated based at least in part on the second digital representation of the anatomic imaging data.

Abstract: Automatic characterization of the Agatston score from coronary computed tomography (CT) is provided. In various embodiments, a plurality of coronary computed tomography images are segmented into a plurality of segments corresponding to features of coronary anatomy. A plurality of calcium candidates are extracted from the plurality of coronary computed tomography images by thresholding. Coronary calcification is located in the coronary computed tomography images by applying a trained classifier to the plurality of calcium candidates. An Agatson score is computed from the located calcification.

Abstract: A fluorescence imaging device detects fluorescence in parts of the visible and invisible spectrum, and projects the fluorescence image directly on the human body, as well as on a monitor, with improved sensitivity, video frame rate and depth of focus, and enhanced capabilities of detecting distribution and properties of multiple fluorophores. Direct projection of three-dimensional visible representations of florescence on three-dimensional body areas advantageously permits view of it during surgical procedures, including during cancer removal, reconstructive surgery and wound care, etc. A NIR laser and a human visible laser (HVL) are aligned coaxially and scanned over the operating field of view. When the NIR laser passes over the area where the florescent dye is present, it energizes the dye which emits at a shifted NIR frequency detected by a photo diode. The HVL is turned on when emission is detected, providing visual indication of those positions.

Abstract: Black blood time to inversion (BBTI) tag-on and tag-off images acquired by magnetic resonance imaging (MRI) are analyzed to produce difference magnitude 3D images as a function of time (BBTI values) representing blood perfusion in a region of interest (ROI). Perfusion data of the ROI having values which are different for normal and abnormal myocardial tissues are displayed for plural slices of a 3D image and for plural BBTI values in a single display panel.

Abstract: Systems and methods employing a depth-sensing camera to detect abdomen rise and fall during an infant sleep period, or lack thereof due to respiratory arrest. Visual processing of image data collected by one or more 3D digital camera is performed to detect the infant and to measure a distance between an infant's abdominal cavity and a camera baseline over time. An alarm may be triggered at by the system, locally and/or at remote devices, such as a mobile phone, tablet, laptop, etc. The monitoring system may also detect situations when an infant rolls from a back-sleeping to a belly-sleeping position.

Abstract: The present invention relates to an ultrasound imaging system and a method for the measurement of a distance (58) between two points (54, 56) within a volume of a three-dimensional image (50). To avoid the commonly known fore-shortening effect, according to which a distance measured by the system is shorter than an actual distance (58) between the two points (54, 56), an in-depth control of a cursor (53) shown in the image (50) on the display as provided to the user. Further, an indication (72) may be given to the user that the cursor (53) collides with a structure (52) within the volume to allow the user to assess the movement of the cursor out of the plane shown on the display more conveniently. By this, occurrence of the fore-shortening effect may be avoided.

Abstract: The invention provides a computer server with a graphical processor that can process data from multiple medical imaging systems simultaneously. Data sets can be provided by any suitable imaging system (x-ray, angiography, PET scans, MRI, IVUS, OCT, cath labs, etc.) and a processing system of the invention allocates resources in the form of a virtual machine, processing power, operating system, applications, etc., as-needed. Embodiments of the invention may find particular application with cath labs due to the particular processing requirements of typical cath lab systems.

Abstract: A photoacoustic remote sensing system (NI-PARS) for imaging a subsurface structure in a sample, has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.

Abstract: A method of assessing the quality of an retinal image (such as a fundus image) includes selecting at least one region of interest within a retinal image corresponding to a particular structure of the eye (e.g. the optic disc or the macula), and a quality score is calculated in respect of the, or each, region-of-interest. Each region of interest is typically one associated with pathology, as the optic disc and the macula are. Optionally, a quality score may be calculated also in respect of the eye as a whole (i.e. over the entire image, if the entire image corresponds to the retina).

Abstract: An eye imaging apparatus includes a lighting device including a fundus illuminator and a cornea illuminator; a half mirror; an imaging device including a camera having a first objective lens; and a first polarizer. The first polarizer is disposed between the half mirror and the camera. The fundus illuminator irradiates the half mirror with first light polarized in a direction orthogonal to a transmission axis of the first polarizer. The half mirror receives the first light and outputs resulting light to an eye. A travel direction of the resulting light is in alignment with an optical axis of the first objective lens. The cornea illuminator emits light at a timing different from an emission timing of the first light, and the eye is irradiated with second light based on the light emitted by the cornea illuminator from a direction different from a direction parallel with the optical axis.

Abstract: Extracting a tubular structure from volume data, determining a target region which should be reached by an endoscope through the tubular structure, extracting, among plurality on a route of the tubular structure, a point that satisfies a given condition as a target point that should be reached by a distal end portion of the endoscope, and identifying and determining a route of the tubular structure from a predetermined start point in the tubular structure to the extracted target point as a route through which the endoscope should be passed.

Abstract: A system and method for planning a pathway through an anatomical luminal network of a patient including memory storing a computer program that is configured to analyze and manipulate CT images, a processor configured to execute the computer program and a display device configured to display a user interface of the computer program. The user interface includes an airway finder window displaying a CT image including a target. The CT image is rotatable about a pre-defined axis of rotation to assist a user in identifying an airway of the anatomical luminal network.

Abstract: According to one embodiment, an ultrasonic diagnostic apparatus comprises an ultrasonic probe, image generation circuitry, image generation circuitry, at least one light emission circuitry a plurality of optical detection circuits, a slide mechanism and analysis circuitry. The slide mechanism makes at least either the at least one light emission circuitry or the plurality of optical detection circuits slide to change positional relationships between the ultrasonic transmission/reception surface, the at least one light emission circuitry, and the plurality of optical detection circuits. The analysis circuitry analyzes a change in the light intensity detected for each of different positional relationships between the ultrasonic transmission/reception surface, the at least one light emission circuitry, and the plurality of optical detection circuits.

Abstract: Disclosed herein are methods and systems for the identification and characterization of fluid accumulation in the retina using OCT imaging. The disclosed methods and systems are directed to the automated segmentation of retinal fluid using 2D or 3D structural OCT scan images. Approaches for visualization and quantification of both intraretinal and subretinal fluid are presented. Methods are also disclosed for using OCT angiography data to improve the quality of retinal fluid segmentation, and to provide combined visualization of fluid accumulation and retinal vasculature to inform clinical interpretation of results.

Abstract: An ultrasound probe acquires a 3D image dataset of a volumetric region of the body. The 3D image data is reformatted into a sequence of successive parallel image planes extending in one of three orthogonal directions through the volume. The sequence of images (74, 84, 94) is preferably formatted in accordance with the DICOM standard so that a clinician can review the 3D image data as a sequence of DICOM images on an image workstation.

Abstract: An integrated intraluminal imaging system includes an optical coherence tomography interferometer (OCT), an ultrasound subsystem (US) and a phase resolved acoustic radiation force optical coherence elastography subsystem (PR-RAF-OCE).

Abstract: A method is presented for correcting errors in a 3D scanner. Measurement errors in the 3D scanner are determined by scanning each of a plurality of calibration objects in each of a plurality of sectors in the 3D scanner's field of view. The calibration objects have a known height, a known width, and a known length. The measurements taken by the 3D scanner are compared to the known dimensions to derive a measurement error for each dimension in each sector. An estimated measurement error is calculated based on scans of each of the plurality of calibration objects. When scanning target objects in a given sector, the estimated measurement error for that sector is used to correct measurements obtained by the 3D scanner.

Abstract: A method is presented for correcting errors in a 3D scanner. Measurement errors in the 3D scanner are determined by scanning each of a plurality of calibration objects in each of a plurality of sectors in the 3D scanner's field of view. The calibration objects have a known height, a known width, and a known length. The measurements taken by the 3D scanner are compared to the known dimensions to derive a measurement error for each dimension in each sector. An estimated measurement error is calculated based on scans of each of the plurality of calibration objects. When scanning target objects in a given sector, the estimated measurement error for that sector is used to correct measurements obtained by the 3D scanner.

Abstract: Methods and apparatuses are disclosed for quantifying regional organ perfusion with low radiation dose using whole-organ CT in a patient comprising obtaining a computed tomography scan of the patient and determining perfusion of the organ using a first-pass analysis method in conjunction with conservation of mass for perfusion measurement.

Abstract: Detecting position information related to a face, and more particularly to an eyeball in a face, using a detection and ranging system, such as a Radio Detection And Ranging (“RADAR”) system, or a Light Detection And Ranging (“LIDAR”) system. The position information may include a location of the eyeball, translational motion information related to the eyeball (e.g., displacement, velocity, acceleration, jerk, etc.), rotational motion information related to the eyeball (e.g., rotational displacement, rotational velocity, rotational acceleration, etc.) as the eyeball rotates within its socket.

Abstract: A system and method utilizing a camera device containing an inertial measuring unit or similar orientation mechanism to calibrate alignment of the camera device according to a primary image such as displayed on an imaging screen, and then utilizing this calibration data to guide the system or user in acquiring a spatially aligned digital image using the camera device. Steps include recording the spatial orientation of the camera in at least two spatial dimensions when aligned with the primary image, and guiding camera alignment relative to the imaging screen when taking a picture.

Abstract: A radiographic system including a radiation source emitting a radiation beam, a radiation sensor for detecting incident radiation from the radiation beam on a sensor area, at least one collimator arranged between the radiation source and the radiation sensor for masking the radiation beam to irradiate a radiation area on the sensor which is smaller than the sensor area and means for moving the collimator across the radiation beam, whereby the radiation area is moved across the sensor area.

Abstract: A system includes acquisition of an image of a patient volume, automatic determination of medical findings based on the image of the patient volume, automatic determination to assign the medical findings to a priority review queue, the priority review queue including medical findings to be reviewed while the patient remains proximate to the medical imaging scanner, reception of an authorization to acquire a second image of the patient volume based on the medical findings while the patient remains proximate to the medical imaging scanner, and acquisition of the second image of the patient volume while the patient remains proximate to the medical imaging scanner.

Abstract: A fluorescence microscopic imaging method includes: after a to-be-detected sample plate is placed, lightening, according to experimental requirements, at least one monochromatic fluorescence excitation light source with a same color among multiple monochromatic fluorescence excitation light sources as a target light source, where monochromatic fluorescence excitation light emitted by each monochromatic fluorescence excitation light source obliquely enters a preset detection region of the to-be-detected sample plate; collecting, at a side of the to-be-detected sample plate facing away from the target light source, fluorescence of particles within the preset detection region excited by irradiation of monochromatic fluorescence excitation light emitted by the target light source, and magnifying the preset detection region a preset number of times; filtering the excited fluorescence of the particles within the preset detection region; and acquiring a fluorescence image of the preset detection region.

Abstract: The ophthalmologic apparatus includes: a scanning unit that scans a fundus of an eye to be inspected with measurement light; a selecting unit that selects one imaging mode out of a first imaging mode and a second imaging mode which is different from the first imaging mode; an acquiring unit that acquires information which indicates a movement amount of the eye to be inspected, based on a plurality of planar images of the fundus; and a correcting unit that corrects a scanning position of the measurement light in an initial scan which is executed after the information indicating the movement amount has been acquired, in the first imaging mode, and corrects the scanning position of the measurement light in an initial scan included in an initial scanning group which is executed after the information indicating the movement amount has been acquired, in the second imaging mode.

Abstract: A method and system is provided for calculating a strain from characterization motion data. The method and system utilize an intravascular mapping tool configured to be inserted into at least one of the endocardial or epicardial space. The mapping tool is maneuvered to select locations proximate to surfaces of the heart, while collecting map points at the select locations to form a point cloud data set during at least one cardiac cycle. The method and system further include automatically assigning segment identifiers (IDs) to the map points based on a position of the map point within the point cloud data set. The method and system further select a first and second reference from a group of map points. Further, the method and system calculate a linear strain based on an instantaneous distance and a reference distance between the first and second references.

Abstract: A method and a system for displaying portions of in vivo images such as pathological or anatomical landmark portions of images, may include receiving a stream of in vivo images captured in a body lumen, and selecting relevant image portions such as suspected pathological image portions from the stream, based on one or more predetermined criteria. A spatial arrangement of the image portions may be determined, and the selected image portions may be resized to an appropriate size, and displayed in a rectangular or hexagonal array layout according to the determined spatial arrangement, such that rows and columns of selected image portions are adjacent to each other.

Abstract: Provided is an optical imaging system which visualizes a deep portion of a scattering body. The optical imaging system generates an image of an object to be inspected by removing a signal resulting from light reflected and scattered once by a surface of the object to be inspected from the signal obtained by means of an optical system analogous to Optical Coherence Tomography, thereby extracting a signal resulting from multiply scattered light.

Abstract: System and method for obtaining information about a target structure. The system includes an optoelectrical element with an optical fiber having a core, a coating surrounding the core, an optical axis, a proximal end, and a distal end. The optoelectrical element also includes an electrical connector embedded within the coating along the optical axis between the proximal end and the distal end. A transducer is disposed at the distal end and electrically connected to the electrical connector. The transducer is operable to detect a first energy, generated in response to light that has been transmitted from the proximal end to the distal end and outcoupled from the distal end toward the target structure, and to convert the received first energy to an electrical signal to be transmitted along the electrical connector.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: An image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to acquire correction information on a luminance value of a contrast image, based on concentration of a contrast material and thickness of the contrast material in a projection direction in a device that is inserted into a blood vessel, in the contrast image. The processing circuitry is configured to correct the contrast image using the correction information.

Abstract: One or more techniques and/or systems are described for inspecting an object, such as a tire. The system comprises a radiation imaging system configured to examine the object via radiation to generate a radiation image depicting an interior aspect of the object and a machine vision system configured to measure visible light and/or infrared wavelengths to generate a vision image depicting an exterior aspect of the object. The radiation image and the vision image may be correlated to facilitate an inspection of the object which includes an inspection of the exterior aspect as well as the interior aspect.

Abstract: In the context of a method for the analysis of image data representing a three-dimensional volume (10, 20) of biological tissue, for each of a number of subvolumes at least two error probability values (41, 42, 43, 44) are generated, each of the values (41, 42, 43, 44) indicating a probability of a type of imaging error, the totality of subvolumes constituting the three-dimensional volume (10, 20). A single consolidated error probability value (51) is determined for each of the number of subvolumes, based on the at least two error probability values (41, 42, 43, 44). Subsequently, the image data is analyzed to obtain a physiologically relevant conclusion applying to a plurality of subvolumes, weighting in the analysis the image data of a given subvolume of the plurality of subvolumes according to the consolidated error probability (51) of the subvolume.

Abstract: In a method and apparatus for reducing variability of representations of regions of interest in reconstructions of original imaging data, a processor performs a reconstruction on the original imaging data to provide original image data, applies a filter to the original image data to provide filtered image data, displays the original image data to a user as an original image, at said display monitor, receives input parameters from the user to define a volume of interest, applies the input parameters to the filtered image data to generate a contour defining the volume of interest in the filtered image data, and displays the contour defining the volume of interest in the filtered image data to the user on the original image at said display monitor.

Abstract: An apparatus and a method are provided for controlling collimation operation of a collimator in an x-ray imager during an intervention carried out by an operator. A first medical device is made to progress through a patient in an exploratory phase of the intervention. A path is recorded in a scout image formed from footprints of the first device as recorded in a sequence of projection images acquired by imager during the exploratory phase. Apparatus uses the path in the scout image to control collimation of the x-ray beam during a subsequent delivery phase where a second medical is made to progress through patient, said second device following the first device substantially along the same path.

Abstract: An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region; and a fiber actuator, housed at least partially in the handle, configured to move the distal fiber-portion to scan the deflected light along a scanning curve in the target region.

Abstract: Determining collateral information describing blood flow in collaterals of a blood vessel system in a target region of a patient from a four-dimensional vascular data set describing image values of temporal flow of a contrast medium and/or marked blood constituents as recorded by a medical imaging device is provided. A method includes segmenting the blood vessel system in the vascular data set and determining collaterals among the segmented blood vessels by a collateral classifier. For all collaterals determined, a diameter of the collateral is determined taking into account the segmentation, a filling parameter describing the filling of the collaterals, and a time parameter describing the time response relative to a reference point in the blood vessel system from a temporal course of the image values in a portion of the collaterals under consideration. The method includes determining the collateral information from the diameter, the filling parameter, and the time parameter.

Abstract: The present invention is directed to a novel tomographic reconstruction framework that explicitly models the covariance of the measurements in the forward model using a mean measurement model and a noise model. This more accurate model can result in improved image quality, increased spatial resolution, and enhanced detectability—in particular, for imaging scenarios where there are features on the order of the correlation length in the projection data. Applications where these methods might have particular benefit include high resolution CBCT applications as in CBCT mammography (where very fine calcifications are difficult to resolve due to detector blur and correlation), musculoskeletal imaging (where fine bone details are important to the imaging task), or in temporal bone imaging where the fine detail structures of the inner ear are also difficult to resolve with standard imaging techniques.

Abstract: A facility for procuring and analyzing information about an anatomical surface feature from a caregiver that is usable to generate an assessment of the surface feature is described. The facility displays information about the surface feature used in the assessment of the surface feature. The facility obtains user input and/or data generated by an image capture device to assess the surface feature or update an existing assessment of the surface feature.

Abstract: A medical image processing apparatus acquires a plurality of medical images obtained by imaging an identical region of an object under different radiographing conditions, acquires a correlation between a signal value and a radiographing condition at a pixel at a same position in the plurality of medical images, acquires a virtual radiographing condition that is different from the radiographing conditions of the plurality of medical images, generates an image for a diagnosis by acquiring a signal value of each pixel based on the correlation and the virtual radiographing condition, and acquires a window width value and a window level value for displaying one medical image of an identical cross section of the object.

Abstract: An apparatus for high resolution positron emission tomography (PET) imaging. The apparatus includes at least a first detector and a second detector arranged to detect gamma rays traveling from a target area, the first detector and the second detector being a detector pair. There is at least one collimator for filtering gamma rays reaching the first and second detectors. The collimator defines respective passages filtering gamma rays reaching the respective first and second detectors, the passages being defined to filter for only gamma ray pairs traveling from the target area at a predetermined range of angles with respect to each other, the predetermined range of angles being in the range of 180°-?E, where ?E is less than 1° and greater than 0°.

Abstract: Computer-implemented methods and apparati for graphically displaying deformations, said deformations defined by comparing a first image of an object (1) with a second image of the same or a different object (1). A method embodiment of the present invention comprises the steps of scanning an object (1) twice to produce first and second images; tabulating deformations and converting said tabulated deformations into a scalar property over a preselected range; quantizing the range into a set of discrete quantization intervals; assigning a unique color out of a discrete or quasi-continuous set of colors to each quantization interval to produce a color overlay; and simultaneously displaying the color overlay and a representation of at least one of the first and second images, whereby said deformations are readily viewable in color.

Abstract: An image processing apparatus includes a tomographic image acquisition unit configured to acquire a polarization-sensitive tomographic image of a subject, and an extraction unit configured to extract, from the polarization-sensitive tomographic image of the subject, a region in which a polarization state is scrambled.

Abstract: A method for reducing radiation from CT measurement of respiratory cycles and a corresponding CT scanner. The method includes: determining a lying direction of a patient to be measured; and setting a tube position for a first respiratory cycle measurement of the patient according to the lying direction.