Using Fiducial Marker Patents (Class 600/426)
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Patent number: 8652148Abstract: A system and method for repairing an area of defective tissue reduces the removal of healthy tissue at the margins of the defect. During excision of diseased or damaged tissue, the system tracks the movement and function of a tissue resection tool within a monitored surgical space. This movement is continuously recorded to create a three-dimensional set of data points representative of the excised volume of tissue. This data set is then communicated to a custom implant forming device which creates a custom implant sized to fit the void created by the excision. The system and method of the present disclosure allows a surgeon to exercise intraoperative control over the specific shape, volume and geometry of the excised area. Moreover, the surgeon may utilize a “freehand” resection method to excise only that tissue deemed to be diseased and/or damaged, because the custom-formed implant will accommodate an irregularly-shaped resection volume.Type: GrantFiled: February 21, 2011Date of Patent: February 18, 2014Assignee: Zimmer, Inc.Inventor: Joel Zuhars
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Publication number: 20140046179Abstract: Simultaneous dual-isotope positron emission tomography (PET) is used to improve disease evaluation. Two distinct molecular probes are simultaneously provided to the imaging target. One of the probes is labeled with a radionuclide that emits positrons to provide double coincidence events in PET. The other probe is labeled with a radionuclide that emits positrons+prompt gammas to provide triple coincidence events in PET. One of the probes is a metabolic probe, and the other probe is a selective probe that includes a ligand or antibody that is biologically responsive to receptor/antigen status. A PET system is employed that can provide simultaneous double coincidence and triple coincidence PET images. The resulting images provide simultaneous metabolic imaging and receptor/antigen imaging. Applications include disease evaluation, such as cancer staging (e.g., for breast cancer, prostate cancer, etc.).Type: ApplicationFiled: April 30, 2012Publication date: February 13, 2014Inventors: Peter D. Olcott, Craig S. Levin, Sanjiv Sam Gambhir
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Patent number: 8644909Abstract: A reference frame is described for use in a radiographic procedure. The reference frame is positionable relative to a joint or bone to be imaged, and is radio-transparent. The frame has embedded or affixed thereto a plurality of computer recognizable radio opaque markers. A method of obtaining three dimensional images of bones and joints using the frame is described.Type: GrantFiled: January 28, 2011Date of Patent: February 4, 2014Inventor: T. Derek V. Cooke
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Publication number: 20140031680Abstract: Apparatus and methods for tracking scanner motion with a tracking illumination emitter mounted on a scanner, the scanner including imaging apparatus that captures a sequence of images of a scanned object as the scanner moves with respect to the scanned object; tracking targets installed off the scanner at positions that are fixed relative to a scanned object; one or more tracking illumination sensors mounted on the scanner, the tracking illumination sensors sensing reflections of tracking illumination emitted from the tracking illumination emitter and reflected from the tracking targets as the scanner moves in the process of scanning the scanned object; and one or more data processors, at least one of the data processors coupled for data communications to the tracking illumination sensors, the data processor determining, as the scanner moves, tracked positions of the scanner based upon values of the reflections.Type: ApplicationFiled: September 30, 2013Publication date: January 30, 2014Applicant: UNITED SCIENCES, LLCInventors: NATHANAEL BERGLUND, HARRIS BERGMAN, SCOTT CAHALL, JERRY FOSTER, EOHAN GEORGE, SAMUEL W. HARRIS, GIORGOS HATZILIAS, KAROL HATZILIAS, RUIZHI HONG, WESS E. SHARPE, DAVID G. STITES, HARRY S. STROTHERS, IV
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Publication number: 20140031681Abstract: A radiological imaging apparatus (10) acquires a radiological brain image of a subject after administration of a radio tracer binding to a target substance indicative of a clinical pathology. In one embodiment, the clinical pathology is amyloid deposits in the brain at a level correlative with Alzheimer's disease and the target substance is amyloid deposits. A processor (C) tests for the clinical pathology by: performing non-rigid registration of the brain image with a positive template (32P) indicative of having the clinical pathology and with a negative template (32N) indicative of not having the clinical pathology; generating positive and negative result metrics (36P, 36N) quantifying closeness of the registration with the positive and negative template respectively; and generating a test result (54) based on the positive result metric and the negative result metric. An independent test result is generated by quantifying a second mode of an intensity histogram for the brain image.Type: ApplicationFiled: April 20, 2012Publication date: January 30, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventor: Frank Olaf Thiele
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Patent number: 8634899Abstract: The invention provides a device for percutaneously implanting an imaging marker for identifying a location within a tissue mass. The subcutaneous imaging marker comprises at least a first element and a second element, each of which have a primary imaging mode. The primary imaging mode of the first element is different from that of the second element.Type: GrantFiled: February 3, 2006Date of Patent: January 21, 2014Assignee: Bard Peripheral Vascular, Inc.Inventors: Ryan L. Goosen, Steven E. Field, Richard M. Chesbrough
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Patent number: 8634898Abstract: A method of compensating for breathing and other motions of a patient during treatment includes periodically generating internal positional data about an internal target region. The method further includes continuously generating external positional data about external motion of the patient's body using an external sensor and generating a correlation model between the position of the internal target region and the external sensor using the external positional data of the external sensor and the internal positional data of the internal target region. The method further includes predicting the position of the internal target region at some later time based on the correlation model.Type: GrantFiled: November 29, 2011Date of Patent: January 21, 2014Assignee: Accuray IncorporatedInventors: John R. Adler, Achim Schweikard
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Patent number: 8626270Abstract: The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.Type: GrantFiled: June 13, 2012Date of Patent: January 7, 2014Assignee: Senorx, Inc.Inventors: Fred H. Burbank, Paul Lubock, Michael L. Jones
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Patent number: 8626269Abstract: An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.Type: GrantFiled: June 8, 2011Date of Patent: January 7, 2014Assignee: Senorx, Inc.Inventors: Michael L. Jones, Paul Lubock, Lloyd H. Malchow
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Patent number: 8620405Abstract: A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and/or hydration and/or radiopaque and/or radio luminescent and/or radioactive properties for detection by X-ray and/or Computer Tomography (CT) and/or MRI and/or Ultrasonic scanning processes and/or Positron Emission Tomography (PET), and one or more markings recognizable by an optical imaging process such as 3D surface scanning.Type: GrantFiled: May 7, 2010Date of Patent: December 31, 2013Assignee: University of UlsterInventors: Brian McClelland, Robert John Winder, Justin Dominic Martin Magee, Paul McCarron
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Patent number: 8611988Abstract: When generating a projection image which is an image formed of image information on a plurality of visual lines viewing a first structure in a three-dimensional medical image from a given viewpoint being projected on a given projection plane, setting an assumed position of a treatment tool in the three-dimensional image, detecting a surface of the first structure from the three-dimensional medical image, identifying a second structure in the three-dimensional medical image located at a position masked by the first structure, detecting an intersection point between an assumed path formed when the treatment tool is moved from the assumed position towards the second structure and the surface of the first structure, and displaying the intersection point in an identifiable manner at a position to which image information on a visual line connecting the viewpoint and the intersection point is projected.Type: GrantFiled: January 28, 2011Date of Patent: December 17, 2013Assignee: Fujifilm CorporationInventor: Masaki Miyamoto
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Patent number: 8611983Abstract: The invention provides methods and apparatus for navigating a medical instrument to a target in the lung. In one embodiment, the invention includes inserting a bronchoscope into the lung, inserting a catheter into the lung through the working channel of the bronchoscope, inserting a tracked navigation instrument wire into the lung through the catheter, navigating the tracked navigation instrument through the lung to the target, advancing the catheter over the tracked navigation instrument to the target, removing the tracked navigation instrument from the catheter, and inserting a medical instrument into the catheter, thus bringing the medical instrument in proximity to the target.Type: GrantFiled: January 18, 2006Date of Patent: December 17, 2013Assignee: Philips Electronics LtdInventor: Neil David Glossop
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Patent number: 8611987Abstract: A method is disclosed for assisting in determination of the suitability of a patient for a scan of the heart of the patient using an X-ray computer tomograph. In at least one embodiment of the method, a) an electrocardiogram of the patient is recorded; b) the electrocardiogram is evaluated by predicting the occurrence time of at least the immediately following R wave on the basis of at least four immediately consecutive R waves of the electrocardiogram which were measured last, and comparing this with the actual measured occurrence time of the next R wave; and c) wherein the quality of the prediction is visualized qualitatively. Further, in at least one embodiment, a device is disclosed including an ECG instrument and a computation device for carrying out the method. At least one embodiment of the invention furthermore relates to a method and a device for scanning the heart of a patient on the basis of a prediction of R waves.Type: GrantFiled: June 18, 2010Date of Patent: December 17, 2013Assignee: Siemens AktiengesellschaftInventors: Thomas Allmendinger, Heiko Mehldau, Thomas Seiler, Carsten Thierfelder
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Patent number: 8611985Abstract: The invention relates to a method of navigation of a tool to be used in a surgical operation for treating a target region within the body of a patient.Type: GrantFiled: January 28, 2010Date of Patent: December 17, 2013Assignee: IMACTISInventors: Stephane Lavallee, Lionel Carrat
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Publication number: 20130324842Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient. The patient specific transarterial attenuation gradient is compared to previously collected data to determine an estimate of a pressure gradient and/or fractional flow reserve (FFR) for the patient. As more data is collected, the data can be added to the database in order to increase the accuracy of future assessments. The database can also be enhanced by adding data generated by canonical models and mathematical analysis.Type: ApplicationFiled: April 23, 2013Publication date: December 5, 2013Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo, Parastou Eslami
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Patent number: 8577501Abstract: A remote control unit configured to wirelessly control a mobile robot moving through an environment and having a robot camera. The remote control unit comprises a privacy button operable by a local user and configured to engage a privacy mode of the mobile robot, and a wireless transmitter configured to emit a wireless control signal to the mobile robot based on input from a keypad of the RC unit. The wireless control signal is configured to cause the robot camera to block the field of view of the robot camera such that the environment of the mobile robot is obscured when the privacy mode of the mobile robot is engaged.Type: GrantFiled: July 31, 2012Date of Patent: November 5, 2013Assignee: iRobot CorporationInventors: Matthew Cross, Tony Campbell
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Patent number: 8571637Abstract: An apparatus for use in tracking movement of a patella through a range of motion during a surgical navigation procedure, comprising a frame fixed in relation to the patella, a patella trial component associated with the frame for fixing the frame relative to the patella, and a reference array configured to attach to the frame, the reference array having first, second and third markers, the first, second and third markers being detectable by a surgical navigation system when exposed to a measurement field of the surgical navigation system.Type: GrantFiled: January 21, 2009Date of Patent: October 29, 2013Assignee: Biomet Manufacturing, LLCInventors: Garrett Sheffer, Ryan Schoenefeld
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Patent number: 8565853Abstract: The present invention is directed to a system and method for performing tissue, preferably bone tissue manipulation. The system and method may include implanting markers on opposite sides of a bone, fractured bone or tissue to facilitate bone or tissue manipulation, preferably in-situ closed fracture reduction. The markers are preferably configured to be detected by one or more devices, such as, for example, a detection device so that the detection device can determine the relative relationship of the markers. The markers may also be capable of transmitting and receiving signals. An image may be captured of the bone or tissue and the attached markers. From the captured image, the orientation of each marker relative to the bone fragment may be determined. Next, the captured image may be manipulated in a virtual or simulated environment until a desired restored orientation has been achieved. The orientation of the markers in the desired restored orientation may then be determined.Type: GrantFiled: August 13, 2007Date of Patent: October 22, 2013Assignee: Depuy Synthes Products, LLCInventors: Robert Frigg, Stuart Weikel, Stefan Schwer, Geoffrey Flexner, Ross Jonathan Hamel
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Patent number: 8560050Abstract: A method for imaging objects is disclosed. In at least one embodiment, the method includes using a first and a second imaging method which differ at least in regard to the spatial resolution or sensitivity. Furthermore, in at least one embodiment, the method includes generating an overview image at least by the first or the second imaging method; simultaneously planning the measurement of the first and the second imaging method on the basis of the overview image; and simultaneously conducting the planned measurements of the first and the second imaging method. A device which conducts at least one embodiment of the method is also disclosed.Type: GrantFiled: February 21, 2008Date of Patent: October 15, 2013Assignee: Siemens AktiengesellschaftInventors: Diana Martin, Sebastian Schmidt
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Patent number: 8549732Abstract: A surgical navigation system for navigating a region of a patient includes a non-invasive dynamic reference frame and/or fiducial marker, sensor tipped instruments, and isolator circuits. The dynamic reference frame may be repeatably placed on the patient in a precise location for guiding the instruments. The instruments may be precisely guided by positioning sensors near moveable portions of the instruments. Electrical sources may be electrically isolated from the patient.Type: GrantFiled: July 1, 2011Date of Patent: October 8, 2013Assignee: Medtronic Navigation, Inc.Inventors: Bruce M. Burg, John H. Dukesherer, Bradley A. Jascob, Paul Kessman
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Patent number: 8548563Abstract: A method and apparatus for registering physical space to image space is disclosed. The system allows for determining fiducial markers as pixels or voxels in image data. The system can correlate and register the determined fiducial points with fiducial markers in physical space.Type: GrantFiled: March 19, 2012Date of Patent: October 1, 2013Assignee: Medtronic Navigation, Inc.Inventors: David A. Simon, Amir Ghanei, Kevin E. Mark, Andrew Lajoie, Geoffrey M. Ruckel
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Patent number: 8526688Abstract: Certain embodiments of the present invention provide a method for correlating data including: receiving from a tracking subsystem a first data set including a tracked position of an object; receiving from an imaging subsystem a second data set including an image of the object; and comparing automatically at least a portion of the first data set with at least a portion of the second data based at least in part on the tracked position of the object and the image of the object. In an embodiment, the comparing automatically the first data set with the second data set is performable in real-time. In an embodiment, the method further includes registering the first data set with the second data set. In an embodiment, the tracking subsystem tracks the object electromagnetically, at least in part. In an embodiment, the imaging subsystem includes an x-ray imaging subsystem. In an embodiment, the first data set is generatable by the tracking subsystem substantially in real-time.Type: GrantFiled: March 9, 2006Date of Patent: September 3, 2013Assignee: General Electric CompanyInventors: Daniel Eduardo Groszmann, Vernon Thomas Jensen, Gerald Lee Beauregard, Peter Traneus Anderson
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Publication number: 20130225987Abstract: A dedicated positron-emission tomography (“PET”) imaging device adapted to perform medical imaging procedures is described. The device includes at least two detector envelopes, each detector envelope adapted to conform to, contact, and stabilize an anatomical region of a patient, at least two gamma cameras, each coupled to an associated detector envelope, and multiple mechanical stages coupled to each of the gamma cameras, each mechanical stage adapted to provide an axis of movement for each of the cameras. In addition, a method of performing an imaging scan of an anatomical region is described. The method includes performing a pre-scan to determine a distribution of a radiotracer, determining a set of scan parameters based at least partly on results of the pre-scan, performing a comprehensive scan based at least partly on the set of scan parameters, and constructing an image based at least partly on the comprehensive scan.Type: ApplicationFiled: September 19, 2011Publication date: August 29, 2013Inventor: Stephen Yarnall
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Patent number: 8509878Abstract: To improve a surgical referencing unit for a surgical navigation system, with which a spatial position and/or orientation of the referencing unit is determinable, the referencing unit comprising a base body and at least one marker element arranged on the base body, and the spatial position of the marker element being determinable by the navigation system, so that the handling thereof is simplified and possible errors are eliminated during use thereof, it is proposed that the at least one marker element be movably mounted on the base body, that the referencing unit comprise a first interface device which is configured for engagement with a second interface device provided on a surgical instrument or an implant in a connected position, and that the at least one marker element be movable into a predefined marker element position in dependence upon the interacting first and second interface devices.Type: GrantFiled: July 8, 2011Date of Patent: August 13, 2013Assignee: Aesculap AGInventors: Tobias Pfeifer, Rainmond Toth
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Patent number: 8509502Abstract: An image analysis system comprising: (a) an image input module adapted to receive a medical image; and (b) an analytic module adapted to segment the image, identify a plurality of vertebrae and label each vertebra.Type: GrantFiled: November 23, 2007Date of Patent: August 13, 2013Assignee: Algotec Systems Ltd.Inventors: Hadar Porat, Shmuel Akerman, Hadas Padan
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Publication number: 20130204121Abstract: The present invention relates to a method and nano-sized particles for image guided radiotherapy (IGRT) of a target tissue. More specifically, the invention relates to nano-sized particles comprising X-ray-imaging contrast agents in solid form with the ability to block x-rays, allowing for simultaneous or integrated external beam radiotherapy and imaging, e.g., using computed tomography (CT).Type: ApplicationFiled: July 15, 2011Publication date: August 8, 2013Inventors: Thomas Lars Andresen, Morten Albrechtsen
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Patent number: 8503745Abstract: A patient defines a patient space in which an instrument can be tracked and navigated. An image space is defined by image data that can be registered to the patient space. A tracking device can be connected to a member in a known manner that includes imageable portions that generate image points in the image data. Selected image slices or portions can be used to register reconstructed image data to the patient space.Type: GrantFiled: October 22, 2010Date of Patent: August 6, 2013Assignee: Medtronic Navigation, Inc.Inventors: David A. Simon, Steven L. Hartmann
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Patent number: 8498693Abstract: An elongated intracorporeal remotely detectable marker includes a core of bioabsorbable fibers. An outer jacket of bioabsorbable fibers is disposed around at least part of the core. In one embodiment, for example, the core has a longitudinal extent and a pair of opposed ends, and the outer jacket is disposed around the longitudinal extent of the core, with the pair of opposed ends being exposed.Type: GrantFiled: April 8, 2011Date of Patent: July 30, 2013Assignee: Senorx, Inc.Inventors: Michael L. Jones, Paul Lubock, John Merritt
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Publication number: 20130190605Abstract: Methods and compositions are provided for objectively characterizing a pathological lesion in a patient. The method comprises: introducing into the patient a contrast enhancing agent; subjecting the patient to at least one of magnetic resonance imaging and computed tomography to obtain an image; and applying a 3-D autocorrelation function to a subdomain of interest of the image to obtain at least one 3-D autocorrelation spectrum. The method may further comprise comparing the at least one 3-D autocorrelation spectrum to a pre-existing 3-D autocorrelation spectrum that is characteristic for the pathological lesion. In one example, the methods and compositions may be useful for identifying and objectively characterizing amyloid plaque deposits characteristic of Alzheimer's Disease.Type: ApplicationFiled: January 20, 2013Publication date: July 25, 2013Inventors: Ananth Annapragada, Zbigniew Starosolski
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Patent number: 8494612Abstract: The invention relates to a method for navigation during medical interventions on tubular organ structures, characterized in that, before the intervention, static image data of the tubular organ structures are recorded and stored, the tubular organ structures are extracted from the image data and their course is converted into a geometric description used during the medical intervention for instrument/organ recording, and the instrument that is spatially localized by a tracking system is successively corrected in relation to the static data, by a transformation that is preferably defined by an optimization method, taking into account the geometric description and information on the previous distance covered by the instrument, or, conversely, the static data are successively corrected in relation to the instrument position, and thus the position of the instrument is associated with the anatomical structures in the static image data.Type: GrantFiled: March 3, 2005Date of Patent: July 23, 2013Assignees: Deutsches Krebsforschungszentrum, Thoraxlinik Heidelberg GmbHInventors: Marcus Vetter, Ivo Wolf, Ingmar Wegner, Hans-Peter Meinzer, Heinrich Becker
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Publication number: 20130184571Abstract: Registration is provided for imaging with an intra-patient probe. The intra-patient probe is used for imaging or the imaging is, at least in part, of the intra-patient probe. Either approach for imaging with an intra-patient probe uses active transitions for registration. In one embodiment, one or more markers in the intra-patient probe are moveable relative to the intra-patient probe, allowing avoidance of occlusions and providing more reliable marker detection for registration. In another embodiment, a value of a parameter for imaging with at least one modality is changed so that acceptable or better registration with an image of another modality may be made. The imaging is repeated with differences, such as field-of-view or scale, allowing for registration for different types of modalities.Type: ApplicationFiled: January 12, 2012Publication date: July 18, 2013Applicant: Siemens Medical Solutions USA, Inc.Inventors: Wilko Gerwin Wilkening, Lex Garbini, Ricardo Espinosa
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Patent number: 8486028Abstract: A tissue marking apparatus includes a marker introducer that has a cannula and a stylet. The cannula has a lumen and a marker exit port. The stylet is slidably received in the lumen. The stylet has a distal end. A tissue marker is configured to be received in the lumen distal to the distal end of the stylet. The tissue marker is a drug-eluting tissue marker for marking a site in a tissue mass, and has a drug-eluting portion having a drug for release to the site and a material that can be imaged using an imaging technique.Type: GrantFiled: September 30, 2011Date of Patent: July 16, 2013Assignee: Bard Peripheral Vascular, Inc.Inventor: Steven E. Field
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Patent number: 8489177Abstract: A fiducial marker for use in a gamma-guided stereotactic localization system for imaging a suspected cancer and guiding a physician in the removal of tissue samples for biopsy. The fiducial marker includes a fiducial source that can be accurately located in a positioning system and used to correlate the location of the positioning system with the detector and therefore the region-of-interest. The fiducial can be made radioactive such that it can be seen by the gamma camera. The fiducial marker enables the accurate positioning of other hardware in proximity to the object to be viewed.Type: GrantFiled: July 16, 2008Date of Patent: July 16, 2013Assignee: Dilon Technologies, Inc.Inventor: Benjamin Lawrence Welch
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Patent number: 8483801Abstract: Methods, apparatuses, and systems relating to image guided interventions on dynamic tissue. One embodiment is a method that includes creating a dataset that includes images, one of the images depicting a non-tissue internal reference marker, being linked to non-tissue internal reference marker positional information, and being at least 2-dimensional. Another embodiment is a method that includes receiving a position of an instrument reference marker coupled to an instrument; transforming the position into image space using a position of a non-tissue internal reference marker implanted in a patient; and superimposing a representation of the instrument on an image in which the non-tissue internal reference marker appears. Computer readable media that include machine readable instructions for carrying out the steps of the disclosed methods. Apparatuses, such as integrated circuits, configured to carry out the steps of the disclosed methods.Type: GrantFiled: November 8, 2010Date of Patent: July 9, 2013Assignee: Veran Medical Technologies, Inc.Inventor: Jerome R. Edwards
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Patent number: 8473026Abstract: A system for monitoring a position of a medical instrument with respect to a patient's body, including a medical instrument, a reference mount attachable to the patient's body for movement with the patient's body, and an electromagnetic unit for association with the reference mount and the medical instrument for monitoring movement of the medical instrument relative to the reference mount. The electromagnetic unit includes a first member attachable to the patient's body and a second member attachable to the medical instrument. The first and second members communicate by electromagnetic radiation.Type: GrantFiled: November 21, 2006Date of Patent: June 25, 2013Assignee: GE Medical Systems Global Technology CompanyInventors: Maurice R. Ferre, Peter D. Jakab, James S. Tieman
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Patent number: 8463357Abstract: The present invention related to an interstitial marker for localizing an organ, tumor or tumor bed within a mammalian body wherein said marker has a proximal end, a distal end, and a continuous intervening length, at least a portion of the intervening length of said marker being visible under at least one imaging modality and having a flexibility such that said marker follows movements and changes of shape of said organ, tumor or tumor bed.Type: GrantFiled: August 18, 2011Date of Patent: June 11, 2013Assignee: Ion Beam Applications S. A.Inventors: Piran Sioshansi, Raymond J. Bricault
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Patent number: 8457718Abstract: Medical apparatus is described including a fiducial component and a position sensor. The component is recognizable as at least a part of a fiducial when appearing in image data of a patient. The component is attachable to the patient. The sensor is attachable to the component at a predetermined location and orientation on the component or is capable of being positioned adjacent the fiducial component without attachment thereto at a predetermined location and orientation. A storage medium is described containing a program which instructs the computer to recognize a predetermined shape of each of at least one portion of a position sensor as at least a part of a real-world fiducial in image data of a patient. The position sensor is adapted to provide position data. Medical apparatus which includes the position sensor and the storage medium is also described.Type: GrantFiled: March 21, 2007Date of Patent: June 4, 2013Assignee: Ethicon Endo-Surgery, Inc.Inventors: James W. Voegele, Robert M. Trusty
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Patent number: 8457719Abstract: An article to enable the creation of a model of a surface includes a flexible substrate and multiple optical tracking points attached to the flexible substrate at predetermined location. The optical tracking points can be tracked by a tracking system, and a data link enables communication from the flexible substrate to a tracking system. Also disclosed is an article that enables the creation of a model of a surface including multiple light emitting diodes attached to the flexible substrate at predetermined locations. Finally, a method of registering an article and a method for creating a model of a surface having a shape are disclosed.Type: GrantFiled: December 8, 2010Date of Patent: June 4, 2013Assignee: Stryker CorporationInventors: Jose Luis Moctezuma de la Barrera, Donald W. Malackowski
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Publication number: 20130137975Abstract: A method for determining whether to administer a therapeutically effective amount of a receptor tyrosine kinase-inhibiting drug for tumor treatment, by determining a glucose uptake response in the tumor of a mammal. 18FDG-PET (2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging) is used as a predictive, non-invasive, pharmacodynamic biomarker of response following administration of drug.Type: ApplicationFiled: February 9, 2011Publication date: May 30, 2013Applicant: OSI PHARMACEUTICALS, LLCInventors: Joseph E. Bugaj, Henry C. Manning, Eliot T. McKinley, Robert C. Wild
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Patent number: 8452379Abstract: A method and system for producing tomosynthetic images of a patient's breast. An x-ray source that delivers x-rays through a breast immobilized and compressed between a compression paddle and a breast platform and form an image at a digital x-ray receptor panel. Multiple x-ray images are taken as the x-ray source and the receptor move relative to the immobilized breast. In one preferred embodiment, the x-ray source travels from ?15° to +15°. The source can travel in an arc around the breast while the receptor travels linearly while remaining parallel and at the same distance from the breast platform. The sets of x-ray image data taken at different angles are combined to form tomosynthetic images that can be viewed in different formats, alone or as an adjunct to conventional mammograms.Type: GrantFiled: September 10, 2010Date of Patent: May 28, 2013Assignee: Hologic, Inc.Inventors: Kenneth F. DeFreitas, Baorui Ren, Chris Ruth, Ian Shaw, Andrew P. Smith, Jay A. Stein
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Publication number: 20130131504Abstract: A surgical hardware and software monitoring system and method allows for surgical planning while the patient is available for surgery, for example while the patient is being prepared for surgery so that the system may model the surgical site. In one embodiment, the model may be used to track contemplated surgical procedures and warn the physician regarding possible boundary violations that would indicate an inappropriate location in a surgical procedure. In another embodiment, the monitoring system may track the movement of instruments during the procedure and in reference to the model to enhance observation of the procedure. In a further embodiment the monitoring system can be used to model and track the changes in the surgical site itself.Type: ApplicationFiled: January 19, 2013Publication date: May 23, 2013Applicant: NAVIDENT TECHNOLOGIES, INC.Inventor: Navident Technologies, Inc.
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Publication number: 20130131505Abstract: The present invention involves a surgical monitoring system and method for modeling surgical procedures. A multi-element fiducial reference pattern observable by a tracker may be transferred directly to the skin proximate the surgical site, either through a stencil as a radio-opaque ink pattern or via transfer tape, or may be applied in prepared form on a surgical incise film. Alternatively the surgical incise film may be applied over the surgical site and the inked reference pattern applied to the film before surgery. A controller determines the three-dimensional location and orientation of the surgical site by comparing the position and orientation of the reference pattern in a prior scan with the position and orientation of the reference pattern in image information about the surgical site obtained from the tracker. The system may track the movement of instruments relative to the surgical site, or may be used to track changes in the surgical site itself.Type: ApplicationFiled: January 19, 2013Publication date: May 23, 2013Applicant: NAVIDENT TECHNOLOGIES, INC.Inventor: Navident Technologies, Inc.
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Patent number: 8447387Abstract: Method and apparatus for real-time tracking of a target in a human body. In one embodiment of the invention, positron emission marker may be implanted into a target, the positron emission marker having a low activity positron isotope. In one embodiment, annihilation gamma rays associated with the low activity positron isotope may be detected using a plurality of position-sensitive detectors. In another embodiment, the target may be tracked in real-time based on a position of the positron emission marker.Type: GrantFiled: April 10, 2007Date of Patent: May 21, 2013Inventors: Tong Xu, Jerry Thwin Wong, Sabee Molloi
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Patent number: 8442618Abstract: A system and method are provided for delivering a medical device on a catheter to a selected position within a lumen of the body. A medical positioning system (MPS) acquires MPS data for points within the lumen using an MPS sensor on the catheter. Each of the points is associated with a three-dimensional coordinate system and an activity state of an organ of the patient. A user interface receives position data for the selected position. The position date is associated with an MPS representation associated with one of the points. A processor determines a plurality of temporal three-dimensional trajectory representations based on the MPS data and corresponding to the respective activity states of the organ. The processor superimposes the temporal three-dimensional trajectory representations on a two-dimensional image according to the activity states of the organ thereby enabling an operator to visually navigate the medical device toward the selected position.Type: GrantFiled: September 16, 2005Date of Patent: May 14, 2013Assignee: MediGuide Ltd.Inventors: Gera Strommer, Uzi Eichler
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Patent number: 8437834Abstract: Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.Type: GrantFiled: September 28, 2011Date of Patent: May 7, 2013Assignee: C. R. Bard, Inc.Inventor: Robert M. Carr, Jr.
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Patent number: 8437449Abstract: A facility for facilitating custom radiation treatment planning is described. During a distinguished radiation treatment session for a patient, the facility collects data indicating positioning of a predefined treatment site of the patient relative to a target treatment location throughout the distinguished radiation treatment session. The facility associates the collected positioning data with data describing one or more other aspects of the distinguished radiation treatment session. The facility provides the associated data to a treatment planning facility to determine a treatment plan for future radiation treatment sessions for the patient.Type: GrantFiled: July 25, 2005Date of Patent: May 7, 2013Assignee: Varian Medical Systems, Inc.Inventors: James K. Riley, Eric Meier, J. Nelson Wright, Steven C. Dimmer, Timothy P. Mate
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Publication number: 20130109961Abstract: An apparatus, method, and computer program product are described below that can provide and/or detect dynamic fiducial markers presented on a display of an apparatus. An apparatus providing the fiducial marker may initially provide for the presentation of the fiducial marker on a display, where the fiducial marker represents one or more properties of the apparatus, such as connectivity information for the apparatus. The apparatus may modify the presentation of the fiducial marker based on a change in one or more properties of the apparatus. An apparatus configured to detect dynamic fiducial markers provided on other device displays may also be configured to provide for the presentation of its own fiducial markers, and vice versa. Thus, in some cases, apparatuses may function as both a tangible user interface display and a tangible object (e.g., in a bi-directional communication scenario).Type: ApplicationFiled: October 31, 2011Publication date: May 2, 2013Applicant: NOKIA CORPORATIONInventors: Raja Bose, Jonathan Lester, Jörg Brakensiek
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Patent number: 8433391Abstract: A site marker and method of using a site marker are described and disclosed. The site marker comprises a bio-compatible and a plurality of elements, wherein the biocompatible material and at least one of the plurality of elements are imageable under different modalities.Type: GrantFiled: November 12, 2008Date of Patent: April 30, 2013Assignee: Suros Surgical Systems, Inc.Inventor: Joseph L. Mark
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Publication number: 20130102895Abstract: One or more geometric markers may be created on an eye preoperatively. Two or more fiducials coupled to or formed within a patient interface may be lined up with the geometric markers. An imaging device coupled to the patient interface and having a field of view oriented through the patient interface and toward the eye of the patient may be utilized to capture one or more images that contain not only image aspects pertinent to the positions of anatomical portions of the eye, but also image aspects pertinent to the locations of fiducials coupled to or formed within portions of the patient interface. The images may be analyzed to determine a geometric relationship between the anatomy of the eye and the associated system hardware.Type: ApplicationFiled: October 21, 2011Publication date: April 25, 2013Applicant: OPTIMEDICA CORPORATIONInventors: Philip Gooding, Michael Wiltberger
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Patent number: RE44305Abstract: An apparatus and procedures for percutaneous placement of surgical implants and instruments such as, for example, screws, rods, wires and plates into various body parts using image guided surgery. The invention includes an apparatus for use with a surgical navigation system, an attaching device rigidly connected to a body part, such as the spinous process of a vertebrae, with an identification superstructure rigidly but removably connected to the attaching device. This identification superstructure, for example, is a reference arc and fiducial array which accomplishes the function of identifying the location of the superstructure, and, therefore, the body part to which it is fixed, during imaging by CAT scan or MRI, and later during medical procedures.Type: GrantFiled: February 28, 2011Date of Patent: June 18, 2013Assignee: Medtronic Navigation, Inc.Inventors: Kevin T. Foley, John B. Clayton, Anthony Melkent, Michael C. Sherman