Abstract: A method and apparatus to select a correlation model from a plurality of correlation models to track target movement based on movement of an external marker.

Abstract: This document discusses, among other things, a fiducial marker kit. In one example, the kit includes a fiducial marker assembly that includes a bone screw base for receiving an imageable marker or locatable divot. A valved protective sleeve prevents debris from accumulating in a receptacle portion of the base, which may otherwise degrade the accuracy of patient registration in an image-guided surgical procedure. In one example, the valve automatically opens or closes upon insertion or removal of a screwdriver or other tool, or a shaft portion of the imageable marker or locatable divot. Various bone screw base and receptacle combinations are also discussed.

Abstract: Methods and systems for determining information about a vascular bodily lumen are described. An exemplary method includes generating an electrical signal, delivering the electrical signal to a plurality of excitation elements in the vicinity of the vascular bodily lumen, measuring a responsive electrical signal from a plurality of sensing elements in response to the delivered electrical signal, and determining a lumen dimension. Specific embodiments include generating a multiple frequency electrical signal. Another embodiment includes measuring plurality of responsive signals at a plurality of frequencies. Still other embodiments include using spatial diversity of the excitation elements. Yet other embodiments use method for calibration and de-embedding of such measurements to determine the lumen dimensions. Diagnostic devices incorporating the method are also disclosed, including guide wires, catheters and implants.

Abstract: A modeling method for use in surgical navigation is provided. The method acquires a finite number of pre-defined points from a patient's bone and registers the points with a surgical navigation system. The navigation system generates and displays a three-dimensional image of a warped bone model that is manipulatable and accurate in at least the locations of the points taken and can be used to calculate the locations of bone cuts, implant positions and sizes, as well as display all of this information on the three-dimensional warped model.

Abstract: A system for positioning a guide relative to an anatomy is provided. The system can include a base adapted to be coupled to the anatomy, and a guide that can move relative to the base. The system can include at least one tracking device that can be coupled to the base and the guide, and a tracking system that tracks a position of the tracking device. The system can include a navigation system that determines a position of the base and the guide relative to the anatomy, and whether the position of the base and the guide are in a desired position. The system can include a display, which can display at least one icon superimposed on the image of the anatomy that graphically indicates a manipulation of the guide required to move the guide into the desired position.

Abstract: A method for planning a procedure, which can include determining anatomical landmarks is disclosed. The anatomical landmarks can be used to determine anatomical targets of a patient. The plan can include a path or trajectory to reach a selected target.

Abstract: A method for determining anatomical landmarks is provided. The anatomical landmarks can be used to determine anatomical targets of a patient. The method may be used for planning a procedure and performing a procedure, such as performing a procedure in the brain.

Abstract: A respiratory marker (40, 140, 240, 340, 440) includes an elongated detectable portion (42, 342, 442) that is operatively coupled with respiration of an imaging subject such that the elongated detectable portion moves with the respiration. The elongated detectable portion is arranged to intersect images acquired by an imaging scanner (10) at different times and at different positions along a scanner axis (20), and is detectable as a marker feature in the images. A marker position finder (52, 54) is configured to determine positions of the marker features in the images.

Abstract: A system including a processor and/or processor system can be used to create a plan for a procedure, such as a surgical procedure. The plan for the surgical procedure can be based on various elements, including determined anatomical landmarks that can be used to determine anatomical targets of a patient. The planning processor can be used to determine the anatomical landmarks and identify anatomical targets in image data of a subject, even if the anatomical targets are indistinguishable in the image data.

Abstract: A method and apparatus for registering physical space to image space is disclosed. The system allows for determining fiducial markers as pixels or voxels in image data. The system can correlate and register the determined fiducial points with fiducial markers in physical space.

Abstract: A system including a processor and/or processor system can be used to identify landmarks in image data. The landmarks can be used to further identify anatomical targets. The landmarks and/or targets can be used to create a plan for a procedure, such as a surgical procedure. The processor can be used to determine the anatomical landmarks that can be used to identify anatomical targets in image data of a subject, even if the anatomical targets are indistinguishable in the image data.

Abstract: A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and/or hydration and/or radiopaque and/or radio luminescent and/or radioactive properties for detection by X-ray and/or Computer Tomography (CT) and/or MRI and/or Ultrasonic scanning processes and/or Positron Emission Tomography (PET), and one or more markings recognisable by an optical imaging process such as 3D surface scanning.

Abstract: A marker navigation system for detecting and displaying locations of at least two reference devices, each reference device attachable to a corresponding object includes a detection device for detecting signals emitted from the at least two reference devices, a display device for displaying the locations of the at least two reference devices and/or the objects attached to the at least two reference devices based in accordance with display signals; and a data processing device.

Abstract: An ultrasound observation apparatus of the present invention is an ultrasound observation apparatus capable of creating a blood flow image of a subject by receiving a reflection signal of a sound output signal transmitted to the subject as an electric signal, and performing various kinds of signal processing for the electric signal, and includes a transmission frequency switching section switching a frequency band of the sound output signal which is transmitted to the subject to a frequency band corresponding to an instruction signal which is outputted from an operation instructing section, and a blood flow color creating section changing a color at a time of visualizing the blood flow image by linking with switching of the frequency band by the transmission frequency switching section.

Abstract: A method is disclosed for achieving improved quality of monitoring and diagnosis for heart functions. Specifically, a method is disclosed for continuous temperature measurement and thermal characterization of patient heart tissue based on non-invasive thermal mapping technology. The method includes multi-dimensional cardiac tissue temperature scanning and tissue thermal pattern analysis with high precision, which can greatly improve the efficiency and lower the medical procedure risk for identifying myocardial ischemia (MI) disorders, predicting the MI occurrence, and mapping MI characteristics and impacting MI medical treatment, such as drug delivery and long term cardiac care. A system is also disclosed for use with the method.

Abstract: A system can be used to determine a position of a structure in physical space. The system can include a flexible member, such as a drape, cloth, sheet, etc. that can include one or more trackable devices associated therewith. The trackable devices can be incorporated into the weave of a woven cloth or the matrix of a polymer member. The trackable devices can be used within a tracking system to determine the location of the trackable devices.

Abstract: The present application relates to an x-ray marker device comprising an arrangement of x-ray markers, wherein the arrangement defines straight lines which are referred to as device straight lines, wherein at least some of the device straight lines, which are referred to as pyramid straight lines, comprise portions which define edges of at least one pyramid.

Abstract: A facility for processing data is described. The facility receives a stream of digital location indications, each location indication identifying a location of a patient while undergoing radiation therapy. In response to each location indication of the string, in substantially real-time relative to the receipt of the position indication, the facility performs an action responsive to the location indication.

Abstract: A spinal midline indicator (10) has a body (14) of radiolucent material for insertion between adjacent vertebrae (18, 20) and a radiographic marker (12) located centrally with the body to indicate the position of the spinal midline (22) in anterior-posterior images when the body is centrally located between the vertebrae. The radiographic marker is typically an elongate metal handle. The body may carry secondary radiographic markers (16) on opposite sides of and equidistant from the handle so that the handle indicates the position of the spinal midline when the body is placed centrally between the vertebrae.

Abstract: A mapping system (200) including: (a) at least one external marker (210,212,214,216) adapted for positioning outside a target (520) to define a target context; (b) at least one target marker (230) adapted for positioning with the target; (c) a data acquisition tool (221) configured to provide position coordinates for at least one data point (220) at the target (520); and (d) a registration module (300) adapted to output position coordinates of said at least one data point relative to at least a portion of the target context.

Abstract: This invention provides a method for estimating C-arm fluoroscope pose. The method involves introducing a coordinate system into a C-arm image, and applying intensity-based 2D/3D registration without segmentation to the coordinate system C-arm image and an image or known model of the coordinate system, wherein the intensity-based 2D/3D registration yields the C-arm pose. The coordinate system may be provided by introducing one or more markers or a fiducial into an image.

Abstract: A method of multi-spectral opto-acoustic tomography (MSOT) imaging of a target tissue including a target tissue biomarker includes illuminating the target tissue with an illumination device emitting at least one pulsed illumination pattern at several illumination wavelengths, detecting pressure signals from the target tissue biomarker with a detector device, wherein the pressure signals being produced in the target tissue are in response to the illumination, and reconstructing a quantitative tomographic image of a distribution of the target tissue biomarker in the target tissue, wherein the pressure signals are analyzed using a photon propagation model which depends on an illuminating light fluence in the target tissue and on the illumination wavelengths, at least one spectral processing scheme, and an inversion scheme providing the tomographic image.

Abstract: This document discusses, among other things, fiducial marker devices, tools, and methods. One example illustrates a combined imagable fiducial locator and divot for receiving a positioning wand of an image-guided surgical (IGS) workstation. A further example is reflective such that it is locatable by a remote detector of an optical positioning system. A generally cylindrical (e.g., faceted cylindrical) columnar locator permits easy application of reflective tape. Other examples discusses a unitary fiducial marker with multiple divots and a swiveling and/or tilted fiducial marker divot, each of which allows manipulation of a positioning wand into a remote camera's field of view. Another example includes at least one reflector that can be aimed. A further example discusses an imagable fiducial marker carrier that is attachable to a single location on a patient's skull to reduce trauma.

Abstract: A method for displaying medical image data. The method includes digitally combining 3D volume visualizations to form a plurality of four-dimensional (4D) volume visualizations representing the 3D volume visualizations over a period of time. The plurality of 4D volume visualizations include first and second 4D volume visualizations. The first 4D volume visualization including the entirety of the common region during a first time period, and the second 4D volume visualization including the entirety of the common region during a different second time period. The method also includes digitally combining the first and second 4D volume visualizations by digitally processing the first and second 4D volume visualizations to generate a modified 4D volume visualization of the entirety of the common region.

Abstract: An improved endoscopic device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, or ultrasonic waveform data. In another aspect of the invention, an improved endoscopic device useful for implanting the aforementioned endoscopic smart probe is disclosed. In another aspect of the invention, apparatus for delivering agents including nanostructures, radionuclides, medication, and ligands is disclosed. In another aspect of the invention, apparatus for obtaining a biopsy of intestinal tissue is disclosed. In another aspect of the invention, apparatus for detecting the presence of one or more molecular species within the intestine is disclosed. Methods for inspecting and/or treating the interior regions of the intestinal tract using the aforementioned apparatus are also disclosed.

Abstract: A site marker delivery system is provided that may be used in combination with a tissue cutting device for marking a biopsy site. The system includes a tube attached to a hub. A push-rod is slidably disposed within the lumen of the tube. The push-rod is advanced forward through the lumen of the tube causing a marker seated within the tube to be deployed at a biopsy site.

Abstract: Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.

Abstract: A site marker is provided that includes a generally hollow body defining a cavity. A deployment line within the site marker positions at least one marker element within the body portion. The deployment line has a first end that is fixedly secured to a first end of the body portion and a second end that is secured to a second end of the body portion. The deployment line is pre-biased so as to pull the first end of the body portion towards the second end of the body portion, and thereby expand the body portion.

Abstract: A drug-eluting tissue marker for marking a site in a tissue mass comprises a drug-eluting portion having a drug for timed release to the site and a material that can be imaged using an imaging technique.

Abstract: A lesion can be made distinctive in an acquired fluorescence image so as to allow for accurate diagnosis. There is provided a fluoroscopic device (1) including a light source unit (2) that emits illumination light, which is in a wavelength range to be absorbed by a blood vessel, and excitation light, which generates agent fluorescence by exciting a fluorochrome accumulated specifically in a lesion, to an examination site (S); an image acquisition unit (15, 16) that acquires an image by irradiating the same examination site (S) with the illumination light and the excitation light and photographing the respective reflected light and fluorescence obtained; and an image processing unit (4) that acquires a reference image by smoothing the luminance of the reflected-light image acquired by the image acquisition unit (15, 16) and corrects the fluorescence image on the basis of the acquired reference image.

Abstract: A system for use during a medical or surgical procedure on a body. The system modifies a reference image data set according to a density image of a body element during a procedure, generates a displaced image data set representing the position and geometry of the body element during the procedure, and compares the density image of the body element during the procedure to the reference image of the body element. The system also includes a display utilizing the displaced image data set generated by the processor to illustrate the position and geometry of the body element during the procedure. Methods relating to the system are also disclosed.

Abstract: To observe a catheter (43) advancing in a vessel system, a 3D model of the vessel system is reconstructed with the help of differently oriented X-ray projections (P1A, . . . ) generated by a C-arm system (20) during the injection of a contrast agent. Next, a movement corridor (M) of the catheter (43) is determined from the 3D model. During an examination procedure, current projections (P) are generated showing an image (43?) of the catheter that can be registered with the reconstructed 3D model and/or the movement corridor (M). Based on the registered catheter image and 3D model of the vessel geometry or the movement corridor (M), an optimal projection direction (dopt) is determined and the C-arm system (20) is controlled to orient the next projections in the optimal projection direction.

Abstract: This document discusses, among other things, fiducial marker devices, tools, and methods. One example illustrates a combined computed tomography (CT) imageable fiducial locator head, an integral bone screw, and an integral divot for receiving a positioning wand of an image-guided surgical (IGS) workstation. A further example includes a fluid/gel-absorbing coating or cover into which a magnetic resonance (MR) imageable fluid is introduced, thereby permitting both CT and MR imaging. Protective caps and collars may be used to protect the fiducial marker from mechanical impact and/or to guide the fiducial marker during affixation. A bull's-eye or other template is used to select a center of a substantially spherical fiducial marker head on an image, such as for use during patient registration.

Abstract: A method and apparatus to track non-linear internal target movement based on movement of an external marker.

Abstract: The present invention is related to an interstitial marker for localizing an organ, tumor or tumor bed within a mammalian body wherein said marker has a proximal end, a distal end, and a continuous intervening length, at least a portion of the intervening length of said marker being visible under at least one imaging modality and having a flexibility such that said marker follows movements and changes of shape of said organ, tumor or tumor bed.

Abstract: A substrate configured for placement on an internal organ or tissue is provided. In certain embodiments, the substrate conforms to and moves with the internal organ or tissue. Three or more sensor elements are integrated on the substrate. In one implementation, the substrate and associated sensor elements provide dynamic referencing of the internal organ or tissue after registration of the sensor data with images and/or volumetric representations of the internal organ or tissue.

Abstract: A system for determining proximity of a surgical device relative to an anatomical structure includes at least one surgical device having a sensor assembly operably coupled to a processing unit. The sensor assembly is configured to transmit at least one electrical signal through the target anatomical structure to elicit a measurable response from the target anatomical structure. The processing unit is configured to calculate a signature property value of the target anatomical structure based on the measurable response and to determine proximity of the at least one surgical device relative to the target anatomical structure based on a comparison between the signature property value and at least one other signature property. An indicator is operably coupled to the processing unit and is configured to alert a user of the identified target anatomical structure based on the determined proximity.

Abstract: A system for determining proximity of a surgical device relative to an anatomical structure includes at least one surgical device having a sensor assembly operably coupled to a processing unit and configured to transmit at least one electrical signal generated by the processing unit through a target anatomical structure to elicit a measurable response from the target anatomical structure. The processing unit is configured to calculate a signature property value of the target anatomical structure based on the measurable response. The processing unit is configured to identify the target anatomical structure based on a comparison between the signature property value and at least one other signature property.

Abstract: A method of performing an arthroplasty of a ball and socket joint with a surgical navigation system includes the step of digitizing landmarks to provide geometrical parameters of the joint and a limb depending there from, including digitizing aspects of a socket region of the ball and socket joint. A range of motion parameter is determined. A soft tissue tension parameter is determined. A functional goal is computed based on landmark data, the range of motion parameter, the soft tissue tension parameter, and a database of potential implants. An optimal socket position is solved for to minimize impingement of potential implants. An implant is chosen based on the optimal socket position and the functional goal. The joint is prepared to receive the chosen implant. The chosen implant is installed into the joint.

Abstract: A surgical apparatus includes a surgical device, configured to be manipulated by a user to perform a procedure on a patient, and a computer system. The computer system is programmed to implement control parameters for controlling the surgical device to provide at least one of haptic guidance to the user and a limit on user manipulation of the surgical device, based on a relationship between an anatomy of the patient and at least one of a position, an orientation, a velocity, and an acceleration of a portion of the surgical device, and to adjust the control parameters in response to movement of the anatomy during the procedure.

Abstract: An apparatus and a method for guiding the placement of an object to a desired location based on an image generated by an image intensifier where the apparatus includes a first coupling mechanism that is configured to be releasably attachable to one of the transmitter and receiver of the image intensifier and a second coupling mechanism that is coupled to the first coupling mechanism and includes an object holding mechanism, the object holding mechanism is configured to releasably hold the object and where at least a portion of the second coupling mechanism is visible in the image generated by the image intensifier when the apparatus is attached to the image intensifier.

Abstract: A method includes receiving during a first time interval image data associated with an image of a dynamic body. The image data includes an indication of the positions of a first marker and a second marker on a garment coupled to the dynamic body. The first marker and second marker are each coupled to the garment at a first and second locations, respectively. A distance is determined between the position of the first marker and the second marker. During a second time interval after the first time interval, data associated with a position of a first and second localization element that are each coupled to the garment is received. A distance between the first and second localization elements is determined. A difference is calculated between the distance between the first marker and the second marker and the distance between the first localization element and the second localization element.

Abstract: A method for converting digital images of an actuated breast into an accurate description of breast surface motion from a digital image-based elasto-tomography system comprises the steps of artificially placing a high density of fiducial markers on the breast surface, whereby the fiducial markers have different qualities and are placed in different proportions according to their quality; utilizing motion invariant properties of the fiducial markers to form a global motion invariant signature; tracking the markers on the actuated breast surface from image to image in each digital camera using the global motion invariant signature; and using the cameras calibration to measure the breast surface motion.

Abstract: A surgical tool for mounting a trackable target to a human bone, suitable for fixation to a human femur. The tool includes a removable bone clamp and a releasable coupling member which is integrated with the removable bone clamp. The releasable coupling member is arranged to mate with a compatible coupling member mounted on the trackable target to establish a predetermined spatial relationship between the bone clamp and trackable target. The releasable and compatible coupling members form a releasable connection which is mechanically constrained to re-engage only in a re-engaged position that accurately recaptures the predetermined spatial relationship.

Abstract: A biopsy marker deployment device adapted to selectively deposit a marker in a target location, such as a biopsy site. In one embodiment, the device includes a deployment assembly comprising a cannula adapted to house at least one marker, an outlet aperture defined by a portion of the cannula, and an actuatable pushrod slidably disposed and movable within the cannula. The deployment assembly further comprises a selectively opening outlet door movable between an open position and a closed position. The outlet door is biased in the closed position and at least partially obstructs the aperture in the closed position to prevent a marker from reentering the cannula upon deployment.

Abstract: A system for position matching of a patient for medical imaging includes a set of RFID tags configured to locate a patient position. A set of RFID interrogators are located to receive RFID position information from the set of RFID tags. A medical imaging system is positioned to produce a medical image of the patient, where the medical imaging system includes a computer. A patient position calculator receives the RFID position information and calculates a patient position for transmission to the computer.

Abstract: A compound comprising a pyridine carboxamide structure, for use in imaging or treating melanoma, is described. An aromatic ring in the structure is substituted with a radiohalogen atom and the substitution on the amide nitrogen atom is such that the compound binds to melanin.

Abstract: The invention is directed to an intracorporeal marker, a delivery device and assembly for such marker and the method of delivering one or more of the markers to an intracorporeal location within a patient. The marker is a body formed at least in part of a bioabsorbable fibrous material such as a fibrous mat or fabric. The delivery devices preferably also include one or more bioabsorbable short term markers which are configured to expand within the body cavity due to contacting a body fluid. The fibrous marker has a radiographically detectable member which preferably hold a portion of the fibrous body in a compressed condition. Preferably, the fibrous marker has a fibrous felt core formed of bioabsorbable material with a fabric jacket formed of bioabsorbable material. Therapeutic, diagnostic and binding agents may be incorporated into the fibrous body of the marker.

Abstract: A device for use in an image-guided procedure on a patient is disclosed. The device includes an EM sensor assembly, a frame assembly (e.g., a base portion from which a plurality of legs project upward to a common point) and a plurality of attachment members. Each attachment member is arranged to be releasably (e.g., adhesively) secured to the skin of a patient and to be coupled to the frame assembly to secure the frame assembly on the skin of the patient. The EM sensor assembly is arranged to be releasably secured to the frame assembly (e.g., pivotably snap-fit into a socket in the frame assembly). The device additionally includes plural visualizable elements (e.g., metal balls) that are adapted to be readily imaged to establish imaging reference points and a plurality of asymmetrically disposed apertures to enable tattooing indicia on the skin of the patient through the apertures.

Abstract: A device and a method for surgically manipulating a bone or bone fragment or a surgical instrument, tool or implant.