Abstract: Automated determination and setting of an ultrasound system transmit power level is provided for contrast agent imaging. Low mechanical index imaging of contrast agents allows substantially continuous imaging of contrast agents without destruction. By comparing data associated with different transmit power levels and spatial locations, different delays between acquisition or different acquisition sequences, a contrast agent imaging transmit power generally minimizing destruction of contrast agents and maximizing signal-to-noise ratio is automatically determined. By using contrast agent specificity for setting the transmit power in addition or alternative to destruction of contrast agents, harmonic imaging may be improved.

Abstract: An embodiment of a medical imaging system is proposed. The system includes means for providing a sequence of recorded input images each one offering a digital representation at a corresponding instant of a body part being perfused with a contrast agent, each input image including a plurality of visualizing values each one representing a corresponding portion of the body part, and means for associating each sequence of corresponding sets in the input images of at least one visualizing value with a model function of time; the system further includes means for generating a sequence of computed images at further instants, each computed image including a plurality of further visualizing values each one being determined by an instantaneous function-value which is calculated from the associated model function at the corresponding further instant, and means for displaying the sequence of computed images.

Abstract: Destruction for reperfusion in medical diagnostic ultrasound is synchronized to motion. Perfusion data for a volume is acquired sequentially for different segments of the volume. For a given segment, such as a planar region, motion tracking within the segment is performed. If sufficient registration or correlation exists at the completion of a sequence of scans for the current segment, then a lesser amount of movement is occurring. At this point, the transmission of contrast agent destructive acoustic energy is performed in the next segment. Tracking is repeated for the next segment to synchronize the switch to yet another segment. Other regions for tracking can be used. By controlling transmission of destruction pulses, more reliable perfusion quantities in a volume may be determined.

Abstract: A perfusion assessment system is proposed.

Abstract: A combined ultrasound imaging and therapy transducer includes a linear array of imaging transducer elements. First and second linear arrays of therapy transducer elements extend longitudinally along respective first and second sides of the imaging transducer elements and are canted inwardly toward each other. The imaging and therapy transducer is used with an ultrasound imaging system to locate clots in a region of interest. After the region of interest has been perfused with a microbubble contrast agent, the therapy transducer elements are driven by an amplifier located in the transducer to dissolve the clot. The use of the imaging transducer elements and the therapy transducer elements can be interleaved so that the therapy can be conditioned on an ultrasound image showing substantial destruction of the contrast agent microbubbles, re-perfusion of microbubbles in the region of interest, or the continued presence of the clot.

Abstract: An ultrasonic diagnostic imaging system acquires a sequence of image data as a bolus of contrast agent washes into and out of a region of interest (ROI) which may contain a lesion. The image data of contrast intensity is used to compute a time-intensity curve at each point in the ROI. Levels of a time-intensity curve are set to define a rise rime period when contrast perfuses the ROI, an enhancement time period when a maximal amount of contrast is sustained in the ROI, and a fall time period when contrast washes out of the ROI. One or more of the time period parameters for the points in the ROI are used to form a parametric contrast image, which is used to identify a lesion in the ROI and its border.

Abstract: Contrast agents are characterized with ultrasound. Flowing or unbound contrast agents are distinguished automatically from bound or relatively stationary contrast agents. The bound or relatively stationary contrast agents are highlighted on a display. A processor distinguishes different types of contrast agents or contrast agents in different binding states with relative signal strength or velocity. Attached contrast agents are differentiated from phagocytosed contrast agents. Monitoring absolute signal strength as a function of time may indicate binding. Any one or more of these features may be used.

Abstract: System parameters for contrast agent medical imaging are conveniently set. A simplified contrast agent configuration is provided where an appropriate contrast agent detection technique and/or contrast agent imaging parameters are achieved consistently and more often then exists with current methods. Examination workflow is improved for contrast agent studies by offering one contrast agent imaging mode or configuration that is dynamically determined and optimized based on the user's selected transmit level and/or a real-time measurement of the contrast agent signals. A simplified user interface provides one contrast agent imaging mode without a need to switch between multiple modes or contrast agent detection techniques and associated contrast agent imaging parameters. The contrast agent detection technique and imaging parameters are adjusting or selected based on changes in the transmit levels for contrast agent imaging.

Abstract: The invention relates to an ultrasound scanner comprising a gel distributing device which is attached, or built into, at least one signal emitting probe. The ultrasound scanner is provided with a gel holder for gel used to transmit ultrasound waves for medical, paramedical and/or veterinary procedure purposes. The holder is fixed to the probe and has an opening in the vicinity of the signal emitting or receiving window of the probe. The holder is a tight, sterile, supple pouch, which is tightly connected by tubes or the equivalent to a pump which, in turn, is tightly connected to at least one probe.

Abstract: The difference frequency component between a first fundamental wave of frequency f and a second fundamental wave of frequency f2 is caused to interact with a second harmonic wave, thereby to attain the enhancement of a second harmonic signal, etc., whereby a reflected wave component to be imaged is extracted at a high S/N ratio. By way of example, in a case where the difference frequency component is to appear on the lower frequency side of the second harmonic wave of the first fundamental wave so as to be superposed on this second harmonic wave, the frequencies are set at f2=2.8f or so. Besides, in a case where the difference frequency component is to appear on the higher frequency side of the second harmonic wave of the first fundamental wave so as to be superposed on this second harmonic wave, the frequencies are set at f2=3.2f or so.

Abstract: A method of ultrasonic detection and localization of contrast agent microbubbles wherein the decision as to whether or not the received ultrasonic signals indicate the presence of a single microbubble or a small microbubble population is made by analyzing the projections of the spectra of said received ultrasonic signals in multidimensional spaces, and by comparing such projections with the projections in said multidimensional spaces of sample control signals corresponding to known conditions of presence and/or absence of single microbubbles and/or small microbubble populations.

Abstract: In one embodiment, at least one visual characteristic from a selected image is used to automatically select an ultrasound image from a set of images from a plurality of heart cycles. In another embodiment, motion correction is performed on ultrasound images that are automatically selected from a plurality of ultrasound images associated with the same phase of the heart cycle. In yet another embodiment, ultrasound images are automatically selected from a set of images based on a time interval that is within a tolerance range from a reference phase of the heart cycle. In another embodiment, a stored user-preference of a phase of the heart cycle is used to automatically select an ultrasound image from a set of images. In yet another embodiment, a user-defined region of interest is placed on an ultrasound image associated with a selected phase of a heart cycle.

Abstract: Provided herein are Pulse-Inversion (PI) sequences that provide for fundamental frequency suppression in nonlinear imaging applications. In an embodiment, a weighting scheme is applied to the received echo pulses resulting from transmit pulses of alternating polarity to reduce the effect of transducer motion. In an embodiment, a three-pulse weighting scheme is applied to a PI sequence. In other embodiments, different combinations of the three-pulse weighting scheme are applied to a PI sequence.

Abstract: Methods, apparatus and systems for measuring a thickness of a portion of a multi-layer vessel based on at least one medical diagnostic image frame using an integrated ultrasound device is provided. The method includes for each x-coordinate determining a y-coordinate along an interface between each layer of the vessel including determining a Y coordinate of a center of an intima-media center (IMC) determining the adventitia-media interface Y coordinate, determining the intima-lumen interface Y coordinate, determining for each X coordinate the lumen-intima interface Y coordinate, determining media-adventitia interface Y coordinate, determining a thickness of at least one vessel layer using X and Y coordinates of respective layer interfaces, and outputting the thickness to a display.

Abstract: Contrast agent destruction transmissions have reduced biological effect in medical diagnostic ultrasound. Ramping-up amplitude and/or ramping-down frequency reduce biological effect. The amplitude ramps up linearly or non-linearly. The change in amplitude or frequency occurs over a single waveform or over a sequence of separate transmissions. An envelope of the single waveform or the sequence of separate transmissions has a non-uniform, asymmetrical, symmetrical, rectangular or other shape. For example, the frequency ramp-down is provided with a non-Gaussian envelope. The amplitude ramp-up or frequency ramp-down is a progressively increasing destructive characteristic or ability, destroying contrast agent at different regions relative to focal regions with a minimum of acoustic energy.

Abstract: The invention relates to a triggered ultrasound imaging method for imaging of the myocardium, minimizing the risk of eliciting cardiac arrhythmia. Particularly, the invention is directed to a method of assessing cardiac perfusion. Destruction pulses are triggered such that they fall within the refractory period of the heart, while imaging pulses are triggered at any given time of the ECG cycle, preferably during end-systole.

Abstract: A method for investigating and ascertaining pulse or heartbeat includes directing illuminating radiation to illuminate a body part such as a finger. The illuminating radiation is of a wavelength or wavelength band substantially in the blue light region of the light spectrum. Then, an optical speckle pattern of the illuminated body part resulting from the illumination of the body part is obtained and imaged. The optical speckle pattern is representative of the heartbeat and by correlation of frames extracted from the speckle pattern, the pulse or beat extent of the body part may be ascertained.

Abstract: A method and system for quantifying the extent of vaso vasorum with contrast enhanced ultrasound and correlating that quantitative value to the risk for vascular disease is provided. An ultrasound contrast agent is administered to a subject and images are obtained using an imaging method that identifies the uptake of the contrast agent by tissues. The amount of uptake is measured and the corresponding signal intensity change correlated with the amount of vaso vasorum present. Additionally, deformations of the vasculature are measured from the series of ultrasound images and this information is coupled with the quantification of the vaso vasorum to determine a risk index indicative of a subject's risk to vascular disease.

Abstract: Ultrasonic diagnostic arrangements (apparatus, methods, etc.) including: an ultrasonic probe or operation for transmitting an ultrasonic wave to an object to be tested and receiving an ultrasonic wave from the object; a transmitter or operation for pulse-driving the ultrasonic probe to transmit an ultrasonic beam to the object; a reception phasing unit or operation for performing phasing on reflected echo signals received by the ultrasonic probe, the reception phasing unit separately performing phasing at multiple phasing frequencies on the reflected echo signals received in response to at least one transmission of the ultrasonic beam; an image generator or operation for generating an ultrasonic image based on the phased received signal.

Abstract: Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.

Abstract: Adaptive grating lobe suppression is provided. Received ultrasound data is measured, compared or otherwise processed to determine the presence of grating lobe energy. A further process is then altered as a function of the level of grating lobe energy. In one embodiment, the adaptive grating lobe suppression is implemented in the receive beamformer. Data representing a virtual element is formed as a normalized sum of data from adjacent sparse elements. The data from the adjacent elements is correlated to determine the presence of grating lobe energy as a function of the amount of shift associated with the peak correlation. A phase shift is applied to the data representing the virtual element where sufficient grating lobe energy is determined. In another embodiment, an amount of grating lobe energy is measured by comparing data from prior to a filter with filtered data. The filter is selected to isolate main lobe energy from grating lobe energy.

Abstract: Disclosed herein is a harmonic quadrature demodulation apparatus and method. The harmonic quadrature demodulation apparatus includes an input terminal for externally receiving an input focused signal, a harmonic phase estimation unit for estimating a second-order harmonic phase component from the input focused signal. The second-order harmonic detection unit includes an in-phase component extractor, a quadrature component extratctor, a Hilbert transformer, an adder and a low pass filter. The in-phase component extractor extracts an in-phase component of the input focused signal. The quadrature component extractor extracts a quadrature component of the input focused signal.

Abstract: In estimation of an aberration in propagation of an ultrasonic wave from an aperture through an aberration path, the aperture is modeled as a plurality of sources and receivers. The frequency-domain magnitude of the aberration is estimated by normalizing the scattered signal power spectrum. The frequency-domain phase of the aberration is estimated by a recursion using cross spectra of signals at neighboring receivers.

Abstract: A method of generating three-dimensional (3D) full volume ultra-sound images with the uses of contrast agents includes acquiring ultrasound image data for multiple subvolumes (140,142,144,146) synchronized to an ECG (100) over multiple cardiac cycles (124,126,128,130) via triggering (104,114,106,116,108,118,110,120). Acquiring includes at least one of two acquisition protocols. The first acquisition protocol uses an output acoustic power insufficient for causing destruction of the contrast agents during ultrasound image data acquisition (10). The second acquisition protocol uses an output acoustic power sufficient for causing destruction of the contrast agents during ultrasound image data acquisition (10). Triggering (26,28) of respective ones of the ultrasound image data acquisitions of the multiple subvolumes (140,142,144,146) is selected to enable destroyed contrast agents to be replaced by new contrast agents prior to a subsequent triggering of ultrasound image data acquisition of a subsequent subvolume.

Abstract: An ultrasonic enhanced-contrast imager and method includes an ultrasonic probe for transmitting and receiving an ultrasonic wave to and from an organism, a transmitting section for transmitting an ultrasonic signal to the ultrasonic probe, a receiving section for processing a response signal ultrasonic wave received by the ultrasonic probe, a filter for extracting a specific frequency component from the processed response signal, and a setting control section for setting a pass frequency band of the filter on the basis of a frequency band of the response signal from a contrast medium injected to the organism. A control section controls the operation of the filter in the set pass band, and the setting control section sets the center frequency of the pass band of the filter to be greater than f0 and less than 2f0, where f0 is the average frequency of the ultrasonic signal transmitted to the ultrasonic probe.

Abstract: An invasive medical device includes a fluid path of microbubbles which is imaged by ultrasound during use of the device. The fluid path extends through the device, preferably to the distal end of the device, so that the diffuse reflection of ultrasound from the microbubbles can be received to image the location of the device. The fluid path can be open, terminating at the tip of the device, or can be a closed path of a circulating microbubble fluid used for imaging and/or cooling.

Abstract: Systems and methods for enhancing diagnostic imaging by the means of increasing tissue perfusion and/or vasodilation, and thus, increasing imaging agent perfusion distribution and/or imaging agent uptake by tissue. The desired effects can be achieved by exposing the area of interest to ultrasound either before or after image acquisition, or in between multiple image acquisitions.

Abstract: Methods and systems are provided for automatic optimization for ultrasound medical imaging. In one approach, velocity values are unwrapped to avoid aliasing artifacts. Multi-dimensional phase unwrapping is applied to the velocity data. The unwrapped velocity information is used to optimize one or both of the velocity scale (e.g., pulse repetition frequency) and the imaging frequency. For optimizing the scale setting, the distribution of unwrapped velocities from a systolic time period of the heart cycle are used to identify the pulse repetition frequency. For optimizing the imaging frequency, a correlation as a function of depth shows the penetration depth for a given imaging frequency. In a dependent or independent approach, one or more thresholds for velocity or energy in flow imaging are adaptively selected as a function of an amount of clutter. Velocity or other energy information in addition to the clutter information may be used for selecting the thresholds.

Abstract: A medical imaging system is proposed.

Abstract: An ultrasonic imaging apparatus and method are described for monitoring the progress of therapy for pathology such as lesions, tumors, and metastases by means of contrast agent imaging. A sequence of images are acquired as a bolus of contrast agent infuses the tissue containing the pathology. A contrast wash-in time parameter is calculated for both the tumor and normal tissue, and a ratio is calculated of the two wash-in time parameters (called WITR) which removes the effects of variations in the procedure from one therapy monitoring session to another. A difference curve of the time-intensity curves of the pathology and normal tissue is also produced, which is similarly immune to procedural variations. The motional effects of respiration can be taken into account by detecting the position of a landmark such as the diaphragm in each of the images of the sequence and discarding from processing those which exhibit a change in the position of the landmark relative to the probe.

Abstract: This invention employs multiple ultrasound pulse firings of either alternating phase and/or amplitude to detect nonlinear fundamental and subharmonic signals from microbubble contrast agents within living tissue, at high frequencies (?15 MHz), e.g., with a linear array transducer. It can be shown that the contrast-to-tissue ratio (CTR) decreases with increasing ultrasound frequency because of nonlinear ultrasound propagation in tissue. However, using the subharmonic signal in addition to the nonlinear fundamental harmonic component, rather than the conventional second harmonic used at lower frequencies, provides appreciable signal strength to overcome the limitations of nonlinear tissue propagation. Additionally, the method provides for the ability to switch, at some desired frequency above 20 MHz, into a purely alternating phase inversion acquisition, in combination with bandpass filtering of the subharmonic frequency band, minimizing the losses in CTR as the frequency increases.

Abstract: Contrast agents are manipulated with acoustic radiation force while ultrasound imaging. Continuous waves for acoustic radiation force are transmitted. Substantially simultaneously, pulsed waves for imaging are transmitted. Low mechanical index continuous and pulsed waves may be used to increase binding efficiency of drug containing contrast agents with the tissue for treatment. Various techniques may be used to minimize the effect of the continuous waves on imaging with the pulsed waves. The acoustic radiation force may be transmitted with an amplitude profile and/or unfocused or defocused.

Abstract: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone stereotactic biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a fiducial marker and three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument with detachable probe/thumb wheel probe to the biopsy site of suspicious tissues or lesions.

Abstract: A method of detecting at least one axillary sentinel lymph node using ultrasonography is described. The method comprises injecting an iron hydroxide compound into a patient at or near a suspected tumor site in the breast and waiting an amount of time required for the iron hydroxide compound to enter cells of the sentinel lymph node. The axillary area near the injection site may then be analyzed using ultrasonography to identify at least one sentinel lymph node. Once identified, a small sample of tissue from the identified sentinel lymph node may be taken for pathological analysis to aid in determination of the stage or extent of breast cancer.

Abstract: A method (50) for quantitative 3D contrast enhanced ultrasound (CEUS) analysis includes acquiring (54) an initial pair of ultrasound contrast and tissue images of an anatomy. A region of interest (ROI) or volume of interest (VOI) is established (56) in the initial acquired tissue image, which becomes the baseline tissue image. The established ROI/VOI is automatically registered (58) from the initial tissue image to the initial contrast image, which becomes a baseline contrast image. Quantitative analysis is performed (60) on the ROI/VOI of the baseline contrast image. The method further includes acquiring (62) a next ultrasound contrast and tissue image pair, corresponding to an i th current contrast and tissue image pair.

Abstract: A method for measuring a non-linear response from a target using an imaging apparatus includes transmitting a signal towards a region of interest from a transducer at a first amplitude and measuring a first response thereto, and transmitting, from the transducer towards the region of interest, at least one additional signal of the same phase as the first amplitude signal but at one or more different, lower amplitudes and measuring at least one additional response thereto. A difference of a function of the measured additional response or responses from the first response is determined, thereby obtaining a non-linear response of the object of interest, and a representation of the non-linear response is displayed.

Abstract: Ultrasound systems for identifying a presence of injected fluid in a region of interest are provided. The ultrasound system includes a controller configured to obtain first and second image data sets of a region of interest from an ultrasound transducer array. A decorrelation module is configured to identify a decorrelation region of decorrelated data that is decorrelated between the first and second image data sets. The decorrelation region indicates a presence of injected fluid in the region of interest.

Abstract: Tissue ablation probes are provided. Each tissue ablation probe comprises an electrically conductive probe shaft, at least one tissue ablation electrode carried by a distal end of the probe shaft, and an electrically insulative outer sheath disposed on the probe shaft. The sheath is at least partially composed of polyether ether ketone (PEEK) and another material comprising condensed-phase particles interspersed throughout the PEEK to increase the echogenicity of the outer sheath. The durability of the PEEK allows the sheath to be formed as thinly as possible, thereby minimizing the diameter of the ablation probe, while the inclusion of condensed-phase particles within the PEEK does not significantly degrade the durability of the sheath.

Abstract: In an ultrasound diagnosis apparatus, a plurality of sub arrays are defined on a 2D array transducer. A plurality of groups are defined for each sub array. Each group is basically composed of a plurality of transducer elements which are connected in parallel with each other. A sub array shape is variably defined for a plurality of sub arrays in accordance with the beam direction and the depth of a focal point. Further, a grouping pattern is variably defined for each sub array. The acoustic distances between the respective transducer elements and the focal point is made as equal as possible for a plurality of transducer elements forming each group, whereby a preferable beam profile can be obtained.

Abstract: The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

Abstract: Using configurable arrays, synthetic aperture processes may be used along an elevation dimension for increasing resolution. The increased resolution is used for two-dimensional or three-dimensional imaging. Alternatively or additionally, wide band synthetic elevation aperture focusing processes, such as beamformation, are provided along the elevation dimension to increase resolution. In yet another alternative or additional embodiment, a transducer is rotated about a center of the transducer within the elevation and azimuth plane. An aperture associated with the transducer is mechanically or electronically rotated, and ultrasound data acquired associated with a plurality of different positions. The ultrasound data is then used for synthetic elevation aperture processing. In yet another alternative or additional embodiment, multiple scanning modes are provided. In a survey mode, imaging is provided without synthetic elevation aperture processing.

Abstract: An ultrasonograph capable of generating a transmission beam comprising a main beam having a uniform width over a wide range in an ultrasonic wave propagation direction by one-time transmission of an ultrasonic pulse. A weighted mean value of a plurality of transmission delay time values corresponding to focal lengths of transmission pulse waves having a plurality of focal points which are set in the ultrasonic wave propagation direction is calculated for each of elements constituting a transmission aperture and used as the delay time. The curvature of a transmitted wave front is close to a short focal length in the center portion of the transmit aperture and is close to a long focal length in the peripheral portion. Thus, a transmission beam including a relatively narrow main beam with a uniform width over a wide range in the ultrasonic wave propagation direction can be generated.

Abstract: Methods and system for controlling an ultrasound system are described. One method includes acquiring ultrasound data relating to an object and iteratively adjusting acoustic power output of the ultrasound system based on the acquired ultrasound data.

Abstract: At least one embodiment of the present application relates to a method and/or an apparatus for determining the concentration of a substance in a body material that is composed of two different material components in an unknown ratio. In an embodiment of the method, two computed tomography pictures from which two image data records are reconstructed are recorded in conjunction with two different spectral distributions of the x-radiation. The x-ray attenuation values for each voxel of the two image data records are decomposed into three material components. The decomposition is performed on the assumption that the x-ray attenuation value xM of the body material without the substance is composed of the x-ray attenuation values xM1, xM2 of the first and second material component in accordance with the following equation: xM=f*xM1+(1-f)*XM2, f being a volume fraction of the first material component in the body material.

Abstract: A transmit sequence for contrast agent imaging that improves sensitivity and minimizes image artifacts. The number of pulses and the interleaving of spatially distinct pulses between spatially co-linear pulses are selected such that a substantially similar pulse sequence for substantially each line in a scanned region is generated. A collateral pulse from a different scan line is interleaved between at least two imaging pulses along a scan line of interest. Such pulse sequences provide sensitive contrast agent imaging with minimized spatial variation. In another aspect, responsive signals representing the first and second scan lines are obtained. Intensities associated with the signals are determined. The intensities associated with the first scan line are compared to a value.

Abstract: A two step method of enhancing the cavitational effect produced by ultrasonic signals focused at a specific location in a medium includes a first step of using one or more transducers to apply the ultrasonic signals to create a waveform that causes formation of bubbles at the location, and a second step of modulating the amplitude of the ultrasonic signals at a frequency of several Hz to several tens of kilohertz immediately following or coincident with the formation of the bubbles.

Abstract: An ultrasound imaging system transmits a broad beam of ultrasound into tissues that are perfused with blood containing microbubbles. The ultrasound has an intensity that is sufficient to destroy the microbubbles in the tissues. A plurality of ultrasound imaging beams are then transmitted into the tissues over a sufficient period to allow the tissues to re-perfuse, and reflections from the transmitted imaging beams are processed to provide a perfusion image. The transmitted microbubble-destroying ultrasound may be in the form of a single beam or a plurality of beams that insonify a substantially larger area than the area insonified by the transmitted imaging beams. As a result, the microbubbles are all destroyed at substantially the same time, and the imaging ultrasound is transmitted only into regions of the tissues from which ultrasound reflections will be received.

Abstract: An ultrasonic diagnosis apparatus and method wherein both imaging of a contrast effect and imaging of a tissue appearance before and after inflow of a contrast medium can be realized on condition that low-power transmission and a high frame rate are maintained. The ultrasonic diagnostic apparatus includes a transmission/reception unit for transmitting subject ultrasonic waves with a band substantially centered at a fundamental frequency and generating a received signal based on an ultrasonic echo from the subject, a harmonic unit for extracting a signal of a harmonic component of the fundamental frequency included in the received signal and extracting a signal of the fundamental component with the band substantially centered the fundamental frequency included in the received signal, and a display unit for generating a display image based on the extracted harmonic and fundamental components.

Abstract: Ultrasound imaging adapts as a function of a coherence factor. Various beamforming, image forming or image processing parameters are varied as a function of a coherence factor to improve detail resolution, contrast resolution, dynamic range or SNR. For example, a beamforming parameter such as the transmit or receive aperture size, apodization type or delay is selected to provide maximum coherence. Alternatively or additionally, an image forming parameter, such as the number of beams for coherent synthesis or incoherent compounding, is set as a function of the coherence factor. Alternatively or additionally an image processing parameter such as the dynamic range, linear or nonlinear video filter and/or linear or nonlinear map may also adapt as a function of the coherence factor.

Abstract: An ultrasound imaging method for use in the presence of contrast agents is disclosed in which acoustic waves are transmitted at a fundamental transmission frequency and are focused on at least one scan line. Acoustic beams reflected from the body under examination and the contrast agents are separated into harmonic and subharmonic components along with the fundamental frequency component. The amplitudes of these components compared to determine whether the reflecting material is either body tissue or the contrast agent.