Measuring Blood Flow In Body Portion Other Than Heart Patents (Class 600/504)
  • Patent number: 10429315
    Abstract: An imaging apparatus includes an illumination light source to output an illumination light, an illumination optical system to transmit the illumination light toward a sample, an imaging optical system to transmit light reflected from the sample, a stage to move the sample in a predetermined transfer direction, and a photographing unit to receive the reflected light. The imaging apparatus may include one or more diffraction grids located at conjugate focal planes of the sample. The operation of the photographing unit may be synchronized with a movement of the sample by the stage to obtain an image in accordance with a time delay integration method.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 1, 2019
    Inventors: Akio Ishikawa, Ken Ozawa, Kwang-Soo Kim, Sean Park, Mitsunori Numata
  • Patent number: 10426359
    Abstract: A dashboard centered around arrhythmia or atrial fibrillation tracking is provided. The dashboard includes a heart or cardiac health score that can be calculated in response to data from the user such as their ECG and other personal information and cardiac health influencing factors. The dashboard also provides to the user recommendations or goals, such as daily goals, for the user to meet and thereby improve their heart or cardiac health score. These goals and recommendations may be set by the user or a medical professional and routinely updated as his or her heart or cardiac health score improves or otherwise changes. The dashboard is generally displayed from an application provided on a smartphone or tablet computer of the user.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 1, 2019
    Assignee: AliveCor, Inc.
    Inventors: Ravi Gopalakrishnan, Lev Korzinov, Fei Wang, Euan Thomson, Nupur Srivastava, Omar Dawood, Iman Abuzeid, David E. Albert
  • Patent number: 10424179
    Abstract: Invention describes set of units able to communicate one with each other by means of cooperating software, mutually control themselves and imagine displays from other units. Invention enables by means of indicated set or individual units as well, to make remote monitoring of persons and control their location, heath condition and capacity. Also, it enables to monitored persons to check their condition on mobile unit.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: September 24, 2019
    Inventor: Vladimir Kranz
  • Patent number: 10405817
    Abstract: An X-ray image diagnosis apparatus includes an X-ray tube, an X-ray detector, a fluid information acquisition unit, a registration unit, and a capturing direction controller. The X-ray tube emits X-rays toward a subject. The X-ray detector detects the X-rays having passed through the subject. The fluid information acquisition unit acquires fluid information on a target site including a region of interest of the subject captured by an ultrasound image diagnosis apparatus. The registration unit extracts position information of a probe of the ultrasound image diagnosis apparatus. The capturing direction controller controls capturing direction for capturing the target site based on the position information and a direction in which a fluid flows indicated by the fluid information.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: September 10, 2019
    Assignee: Canon Medical Systems Corporation
    Inventors: Satoshi Wakai, Tetsuya Yokota
  • Patent number: 10388405
    Abstract: Systems and methods are disclosed herein for quantitatively identifying a patient's sedation level and predicting adverse events, based on one or more capnograms or outputs from a pharmacokinetic, pharmacodynamic, or ventilatory model. A sensor measures a carbon dioxide concentration of air exhaled by a patient into a breath receiver. A processor processes the sensor data to generate a capnogram including one or more respiratory cycles, computes the outputs of pharmacokinetic, pharmacodynamic, or ventilatory models, and extracts one or more of the resulting features from the capnogram and pharmacokinetic, pharmacodynamic, or ventilatory model outputs. A multi-parameter metric is computed based on the one or more extracted features and estimates the current or predicted sedation level of the patient.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: August 20, 2019
    Assignees: Massachusetts Institute of Technology, Children's Medical Center Corporation
    Inventors: George Cheeran Verghese, Margaret Gan Guo, Rebecca Mieloszyk, Thomas Heldt, Baruch Shlomo Krauss
  • Patent number: 10368757
    Abstract: The present disclosure provides for each of a method of characterizing divergence of a monitored flow rate of blood through an implantable blood pump, and a method of predicting an upcoming adverse cardiac event using operating data of the blood pump, such as the characterized divergence data. Predicting an upcoming adverse cardiac event may be further based on similar operating data from a plurality of other implantable blood pumps.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: August 6, 2019
    Assignee: HeartWare, Inc.
    Inventors: Zoe Demou, Antonio Luiz Silva Ferreira
  • Patent number: 10373318
    Abstract: Methods and systems are disclosed for segmenting an image. First and second frames of image data are generated at different times. A first portion of the first frame is compared to image data of the second frame, and a second portion of the second frame is selected based on the comparison. A displacement vector between the first portion and the second portion is calculated, where the displacement vector represents relative movement over time between the image data represented by the first portion and the image data represented by the second portion. An image is output with an indicator, and the location of the indicator on the image is determined by using the calculated displacement vector. The indicator can serve to distinguish between items in an imaging view.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: August 6, 2019
    Inventors: Advit Bhatt, Wouter Vlaanderen, Jung Wook Suh
  • Patent number: 10362945
    Abstract: The invention relates to a method and a device for ascertaining a time-dependent blood pressure curve. Time- and volume-dependent blood flow values are detected in a noninvasive manner in a tissue section with a good blood flow as photoplethysmography values P(t) using a photoplethysmography sensor. A data processing unit transforms the photoplethysmography values P(t) into blood pressure values B(t) by carrying out a transformation rule. An output and storage unit at least temporarily stores the transformed blood pressure values B(t) as time-dependent blood pressure values and transfers said values to an external or internal display and/or storage unit arranged downstream.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: July 30, 2019
    Inventor: Hans-Georg Ortlepp
  • Patent number: 10304185
    Abstract: The method comprises identifying, in a 3D volume, a zone of a first type (H), a zone of a second type (BZ) and a zone of a third type (C) and: —automatically identifying as a candidate channel (bz) a path running through the zone of a second type (BZ) and extending between two points of the zone of a first type (H); and—automatically performing, on a topological space (H_and_BZ_topo), homotopic operations between the candidate channel (bz) and paths (h) running only through the zone of a first type (H), and if the result of said homotopic operations is that the candidate channel (bz) is not homotopic to any path running only through the zone of a first type (H) identifying the candidate channel (bz) as a constrained channel. The computer program product implements the steps of the method of the invention.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: May 28, 2019
    Inventors: Martin Steghöfer, Luis Serra Del Molino, Josep Brugada Terradellas, Josep Lluis Mont Girbau, Antonio Berruezo Sánchez
  • Patent number: 10297140
    Abstract: Obtaining a target location of a user associated with a body worn device (50) that receiving information related to a condition of user and communicates an indication of the condition to a server (12) over a network (24). The method including: providing a network (24) formed of a plurality of lighting units (42, 32) and a database (22) for maintaining information describing a geographic location of each of the plurality of lighting units, each lighting unit transmitting a unique identifier; providing the body worn device with a lighting unit identifier sensor (52), the sensor receiving lighting unit identifiers of at least one of the plurality of lighting units; the body worn device communicating the received lighting unit identifiers with the indication in a message to the server via the network; and the database providing a geographic location of the one or more lighting units, the geographic location corresponding to the target location of the body worn device.
    Type: Grant
    Filed: January 2, 2013
    Date of Patent: May 21, 2019
    Assignee: SIGNIFY HOLDING B.V.
    Inventors: Dave Alberto Tavares Cavalcanti, Amjad Soomro, Jianfeng Wang
  • Patent number: 10244951
    Abstract: Methods of measuring Fractional Flow Reserve (FFR) including advancing a sensor delivery device within a guiding catheter to a location of interest, the sensor delivery device comprising a distal sleeve including a distal sensor and a proximal sensor, advancing only a distal portion of the distal sleeve outside of the guiding catheter such that the distal sensor is outside of the guiding catheter and downstream of the location of interest and the proximal sensor is inside of the guiding catheter, measuring a distal fluid pressure with the distal sensor distal to the location of interest, measuring a reference fluid pressure with the proximal sensor inside of the guiding catheter, and calculating FFR. One or both of the proximal and distal sensor may be comprised of a material having a low thermal coefficient.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: April 2, 2019
    Assignee: ACIST Medical Systems, Inc.
    Inventor: Jason F. Hiltner
  • Patent number: 10219946
    Abstract: A method and a system for detecting a movement of a surface on an irradiated sample involves a light source for irradiating the surface with a coherent light beam, a detector for detecting variations caused by the movement in a speckle pattern produced by reflections of the light beam at the surface, selecting a single speckle from the speckle pattern, and detecting the variations at the selected speckle.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: March 5, 2019
    Assignee: Medizinisches Laserzentrum Luebeck GmbH
    Inventors: Andreas Fritz, Ralf Brinkmann
  • Patent number: 10218883
    Abstract: A digital imaging and analysis system and method. The digital cameras and logger is encased by a weatherproof housing for easy deployment and maintenance of the camera and logger and protection from harsh conditions. The digital camera is associated with a memory to which imagery acquired by the digital camera is saved. The digital camera and logger can be customized and pre-programmed and the imagery subject to custom visualization. Sensors are electronically associated with the digital camera and are triggered to permit the digital camera to acquire the imagery and image the same image footprint in RGB, HSV, l*a*b* color spaces. Selectable regions of interest with respect to the imagery are saved in the memory.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: February 26, 2019
    Inventors: Gesuri Ramirez, Geovany Ramirez, Craig Tweedie, Emmanuel Ochoa
  • Patent number: 10213612
    Abstract: A method for operating a defibrillator including an aural output device includes causing the output device to deliver a first verbal instruction which includes a prompt to call an emergency response system; determining if the user elects to have the defibrillator continue on to a second instruction; and if it is determined that the user elects to have the defibrillator continue on to the next instruction, causing the defibrillator to deliver the second verbal instruction. In an exemplary embodiment, the step of determining if the user elects to continue on to the second instruction includes the step of determining if the user has performed an action upon the defibrillator.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: February 26, 2019
    Inventors: Richard C. Nova, Shawn R. Bertagnole
  • Patent number: 10176339
    Abstract: A data processing system may include a local computing device to receive medical data including a patient's protected health information (PHI) and at least one medical image associated with the patient; an anonymizing device to separate the PHI with the medical image; an image processing unit to analyze the medical image; and a processed results managing (PRM) unit configured to recognize and link analyzed results of the medical image to the corresponding patient's PHI, and combine the analyzed results and the patient's PHI to generate an analysis report. The present invention is advantageous because it allows medical images to be analyzed off-site while minimizing the risk of compromising the patient's PHI. Furthermore, the anonymized medical analysis can be used to guide and improve medical treatment especially during a medical procedure.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 8, 2019
    Inventor: Jordan Patti
  • Patent number: 10170206
    Abstract: Systems, methods, and computer readable media are disclosed for estimating values of hemodynamic forces acting on plaque or lesions. One method includes: training a system that can predict values of hemodynamic forces acting on one or more points of one or more plaque progressions or erosions on a geometric model of at least a portion of a vascular system; receiving one or more patient-specific parameters of the vascular system of a patient; constructing a geometric model using the received parameters; identifying one or more plaque progressions or erosions; using the trained system to estimate values of hemodynamic forces acting on the identified one or more plaque progressions or erosions of the geometric model of the patient, using the received patient-specific parameters; and outputting the estimated values of hemodynamic forces to an electronic storage medium or display.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: January 1, 2019
    Assignee: HeartFlow, Inc.
    Inventors: Bon-Kwon Koo, Gilwoo Choi, Hyun Jin Kim, Charles A. Taylor
  • Patent number: 10161857
    Abstract: A metamaterial optical member 100 includes a light collecting optical member 1 having a light-entering surface IN1 and a light-exiting surface OUT1 and having a light collecting function and an antireflection film 2 disposed in the light-exiting surface OUT1 of the light collecting optical member 1. The antireflection film 2 has a first metamaterial structure in which a refractive index is gradually reduced in the light travelling direction. The metamaterial optical member 100 includes the antireflection film 2 having the metamaterial structure, thereby externally extracting light.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: December 25, 2018
    Inventor: Yoshiro Nomoto
  • Patent number: 10136822
    Abstract: Noninvasive methods and apparatus for detecting blood volume imbalances in a mammalian subject are disclosed. The method includes obtaining baseline measurements of at least three physiological parameters from a subject wherein the parameters are selected from the group consisting of heart rate, electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity. Measurements of electrical body impedance, skin temperature, perfusion index, peripheral blood flow and skin humidity are taken at one or more extremities of the subject such as the calf, ankle, forearm, thigh, fingers and toes. The physiological parameters for which baseline measurements were obtained are then monitored to detect changes from the baseline measurements that indicate blood volume imbalances.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: November 27, 2018
    Assignee: Zynex Monitoring Solutions Inc.
    Inventor: Thomas Sandgaard
  • Patent number: 10130256
    Abstract: The invention relates to a medical device in combination with an optical reading device comprising at least one sensor, a meter display for displaying a matrix of pixels and a meter control unit adapted for controlling the meter display so that at least one measurement value measured by the sensor and/or a value derived thereof is encoded in an optical machine-readable signal, wherein the optical reading device is adapted to read the optical machine-readable signal from the medical device, to decode the optical machine-readable signal and to generate a message corresponding to the decoded optical machine-readable signal.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: November 20, 2018
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Lars Berger, Marcus-Meinolf Dittrich, Anton Petkov
  • Patent number: 10052040
    Abstract: A photobiological measurement apparatus 1 may include a second received light quantity information calculation unit 33 for calculating measurement data relating to cerebral activity, a data display controller for displaying the measurement data for a specified area of a subject's brain, is characterized: is being provided with a reference light-receiving probe 14, which is disposed at a position separated by a first setting distance r1 from the light-transmitting prober 12 that is shorter than a second setting distance r2, and a first received light quantity information calculating unit 32, which calculates skin blood flow data relating to the skin blood flow using first received light quantity information ?A1 from the light transmitting probe 12 to the reference light-receiving probe 14, and in displaying the skin blood flow data at a specified position of the subject's scalp by indicating the measurement position on the subject's scalp and displaying the skin blood data.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: August 21, 2018
    Assignee: Shimadzu Corporation
    Inventors: Akihiro Ishikawa, Yoshihiro Inoue, Takashi Amita, Satoru Kohno, Yoshinori Masuda, Haruhide Udagawa
  • Patent number: 9999361
    Abstract: In order to assess coronary artery disease from medical image data, an anatomical model of a coronary artery is generated from the medical image data. A velocity of blood in the coronary artery is estimated based on a spatio-temporal representation of contrast agent propagation in the medical image data. Blood flow is simulated in the anatomical model of the coronary artery using a computational fluid dynamics (CFD) simulation using the estimated velocity of the blood in the coronary artery as a boundary condition.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: June 19, 2018
    Assignee: Siemens Healthcare GmbH
    Inventors: Puneet Sharma, Bogdan Georgescu, Viorel Mihalef, Terrence Chen, Dorin Comaniciu
  • Patent number: 9844340
    Abstract: A device measuring an electrical activity of a heart and being wearable on a body part of a user. The device comprises a strap configurable to be fitted over the body part, and having an interior surface contacting the body part when worn by the user, and an exterior surface facing away from the body part. The device also includes a first sensor that is disposed on the interior surface. The first sensor is configurable to be in contact with the body part. The device also includes a clasp having a second sensor that is electrically insulated from the first sensor. The first sensor and the second sensor receive data indicative of an electrocardiogram (ECG) signal of the user when the clasp holding the strap over the body part contacts a different body part of the user.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: December 19, 2017
    Inventors: Ram Fish, James Schuessler, Frank Settemo Nuovo, Sheldon George Phillips
  • Patent number: 9824441
    Abstract: A system and method for assessing the concentration of a fluid component within a container, the method comprising: receiving data associated with an image of the canister; from the image, detecting a color grid comprising color elements coupled to the canister,; selecting a region of the image corresponding to a portion of the canister; determining a match between a detected color of the region and a shade in the set of colors associated with the color grid captured in the image; based upon a position of a color element corresponding to the shade in the color grid, retrieving a concentration of the blood component associated with the shade of color.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 21, 2017
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Kevin J. Miller, Christopher Madison, Andrew T. Hosford, Titas De, Ali Zandifar, Eric Lindquist, Juan Carlos Aragon
  • Patent number: 9794653
    Abstract: A wearable biometric monitoring device is configured to assess the biometric signal quality of one or more sensors associated with the monitoring device, determine how the user should adjust the device to improve the biometric fit, and instruct the user to wear the biometric monitoring device a certain way. Communicating instructions to a user may include instructing the user to execute a testing regimen while wearing the biometric monitoring device. The testing regimen facilitates an estimation of a signal quality that can be used to provide feedback to the user that he/she needs to adjust the device to improve the biometric fit and the biometric signal quality.
    Type: Grant
    Filed: August 18, 2015
    Date of Patent: October 17, 2017
    Assignee: Valencell, Inc.
    Inventors: Michael Edward Aumer, Steven Francis LeBoeuf
  • Patent number: 9788738
    Abstract: A system and method prevents and diagnoses deep vein thrombosis in a body limb by providing a pressure sleeve having a plurality of individually fillable cells, the pressure sleeve being configurable to be placed around a body limb. A source fills each fillable cell individually, and a pressure sensor measures a pressure in a fillable cell. A controller establishes a fill sequence of each individually fillable cell and a fill time for each individually fillable cell. The controller causes a first individually fillable cell of the pressure sleeve to be filled to a predetermined pressure and causes the pressure of first individually fillable cell of the pressure sleeve to be measured while a second individually fillable cell of the pressure sleeve is filled. The controller determines a presence of deep vein thrombosis in a body limb having the pressure sleeve therearound based upon a measured pressure change in the first individually fillable cell of the pressure sleeve.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: October 17, 2017
    Inventors: Jacob Barak, Adi Dagan, Vitaly Rondel
  • Patent number: 9772346
    Abstract: Air data sensing apparatus comprising: an aircraft panel; a blister arranged on a surface of the aircraft panel, the blister comprising an upstream portion and a downstream portion, the upstream portion being rounded in three dimensions and having a rounded outer edge surface spaced laterally from the aircraft panel; a plurality of apertures in the surface of the aircraft panel, the apertures being adjacent to the upstream portion of the blister, and spaced from the blister; a plurality of conduits, each conduit being in fluid communication with a respective aperture; and one or more pressure sensors arranged to measure a pressure in each of the conduits.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: September 26, 2017
    Assignee: BAE SYSTEMS PLC
    Inventor: William Frank Ellison
  • Patent number: 9773320
    Abstract: A method and system for assessing an amount of a blood component of a volume of fluid within a canister, the method comprising: receiving an image of the canister generated by the image acquisition device; selecting a first region of the image exhibiting substantially uniform color, wherein the first region of the image corresponds to a layer of fluid situated between a wall of the canister and a first feature of an insert retained in position within the canister; determining a color parameter representative of the first region; determining a concentration of a blood component within the canister, based upon the color parameter; upon determining the volume of fluid of fluid within the canister, generating an analysis informative of an amount of the blood component within the canister; and providing information derived from the analysis to an entity associated with an individual from whom the volume of fluid originated.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: September 26, 2017
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Kevin J. Miller, Yaser Yacoob, Andrew T. Hosford, Charlie Carroll, Grant Kadokura, Tyler Stout, Juan Carlos Aragon, Michael Hsieh
  • Patent number: 9766104
    Abstract: A magnetic-inductive flow-through measurement system, having a measuring tube for an electrically conductive medium, a magnetic field generating device for generating a magnetic field running at least perpendicular to the longitudinal axis of the measuring tube, at least two measuring electrodes which tap the measurement voltage induced in the electrically conductive medium, and an evaluation unit, wherein the measuring electrodes have measuring contact which are accessible externally on the measuring tube, and the measuring tube together with the measuring electrodes form a first functional unit, and counter-contacts corresponding to the measuring contacts, the magnetic field generating device and the evaluation unit form a second functional unit in a measurement system housing.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: September 19, 2017
    Assignee: Krohne AG
    Inventors: Christine Perfetti, Juan Carlos Gonzalez-Pelayo
  • Patent number: 9700219
    Abstract: A method and system for determining fractional flow reserve (FFR) for a coronary artery stenosis of a patient is disclosed. In one embodiment, medical image data of the patient including the stenosis is received, a set of features for the stenosis is extracted from the medical image data of the patient, and an FFR value for the stenosis is determined based on the extracted set of features using a trained machine-learning based mapping. In another embodiment, a medical image of the patient including the stenosis of interest is received, image patches corresponding to the stenosis of interest and a coronary tree of the patient are detected, an FFR value for the stenosis of interest is determined using a trained deep neural network regressor applied directly to the detected image patches.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: July 11, 2017
    Assignee: Siemens Healthcare GmbH
    Inventors: Puneet Sharma, Ali Kamen, Bogdan Georgescu, Frank Sauer, Dorin Comaniciu, Yefeng Zheng, Hien Nguyen, Vivek Kumar Singh
  • Patent number: 9547820
    Abstract: A method of classifying an input pattern and a pattern classification apparatus are provided. The method includes enabling an artificial neural network to learn based on learning input data received by an input layer of the artificial neural network, determining classification of an input pattern received by the input layer of the enabled artificial neural network according to an output value obtained from an output layer of the artificial neural network, the obtained output value being based on the input pattern, updating connection intensities of a plurality of connection lines of the enabled artificial neural network to output a result value indicating the determined classification from the output layer when the input pattern, and determining updated classification of the input pattern according to an updated output value obtained from an output layer of the updated artificial neural network, the obtained updated output value being based on the input pattern.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: January 17, 2017
    Inventors: Youn-ho Kim, Chang-mok Choi, Kun-soo Shin, Myoung-ho Lee, Jin-kwon Kim
  • Patent number: 9536303
    Abstract: A magnetic resonance (MR) system (10) generates an attenuation or density map. The system (10) includes a MR scanner (48) defining an examination volume (16) and at least one processor (54). The at least one processor (54) is programmed to control the MR scanner (48) to apply imaging sequences to the examination volume (16). In response to the imaging sequences, MR data sets of the examination volume (16) are received and analyzed to identify different tissue and/or material types found in pixels or voxels of the attenuation or density map. One or more tissue-specific and/or material-specific attenuation or density values are assigned to each pixel or voxel of the attenuation or density map based on the tissue and/or material type(s) identified as being in each pixel or voxel during the analysis of the MR data sets. In one embodiment, the tissue and/or material types are identified on the basis of a time series of MR phase images.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: January 3, 2017
    Inventors: Bryan James Traughber, Melanie Suzanne Kotys, Raymond Frank Muzic, Jr.
  • Patent number: 9483837
    Abstract: What is disclosed is a system and method for compensating for motion during processing of a video of a subject being monitored for physiological function assessment. In one embodiment, image frames are received. Successive batches of N video frames are processed to isolate pixels associated with a body region of the subject where a physiological signal is registered by the camera. The pixels are processed to obtain a time-series signal for each batch. A determination is made whether movement during video acquisition of this batch of image frames exceeds a threshold level. If so then a size N of the next batch of image frames is changed to: N=N+M1, where N+M1?Nmax. Otherwise, a size N of a next batch is changed to: N=N?M2, where N?M2?Nmin. Thereafter, processing repeats in a real-time continuous manner as the next batch of the N image frames is received. Various embodiments are disclosed.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 1, 2016
    Assignee: Xerox Corporation
    Inventors: Beilei Xu, Survi Kyal, Lalit Keshav Mestha, Graham S. Pennington
  • Patent number: 9474453
    Abstract: Non-invasively measuring a physiological parameter by applying to a subject's body part a venous occlusion plethysmographic device including a first section having a first fluid chamber and at least a second region having a second fluid chamber to engage a first region of the body part and a second region of the body part, proximal of the first region; pressurizing the first chamber to a pressure sufficient to compensate for hydrostatic pressure added to the inherent venous pressure at the maximal vertical lowering level of the body part relative to the subject's heart level; intermittently raising and lowering the pressure in the second fluid chamber to a pressure above or equal to the pressure in the first chamber, but below the arterial blood pressure; measuring changes in volume of the first region of the body part; and utilizing the measured volume changes to provide a measure of the physiological parameter.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: October 25, 2016
    Assignee: Itamar Medical Ltd.
    Inventor: Robert P. Schnall
  • Patent number: 9389224
    Abstract: The invention relates to a method of coating beads with a biological molecule comprising: (i) coating a plurality of beads with the biological molecule; (ii) mixing the coated beads with a liquid stabilizing and/or blocking agent (iii) dispersing the coated beads still substantially surrounded by a liquid phase comprising the liquid stabilizing and/or blocking agent across a surface that is at least partially liquid permeable; (iv) drying the beads on the surface to substantially remove the liquid phase; and (v) removing the dried beads from the surface.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: July 12, 2016
    Assignee: The Binding Site Group Limited
    Inventors: Roger Budd, David Taylor
  • Patent number: 9364143
    Abstract: Exemplary apparatus, arrangement and method can be provided for obtaining information associated with an anatomical structure or sample using optical microscopy. A radiation can include first electromagnetic radiation(s) directed to an anatomical sample and at least one second electromagnetic radiation directed to a reference. A wavelength of the radiation can vary over time, and the wavelength can be shorter than approximately 1150 nm. An interference can be detected between third and forth radiations associated with the first, second and fourth radiation, respectively. At least one image corresponding to portion(s) of the sample can be generated using data associated with the interference. Source arrangement(s) can be provided which is configured to provide an electromagnetic radiation having a wavelength that varies over time. A period of a variation of the wavelength of the first electromagnetic radiation(s) can be shorter than 1 millisecond, and the wavelength can be shorter than approximately 1150 nm.
    Type: Grant
    Filed: May 7, 2012
    Date of Patent: June 14, 2016
    Inventors: Seok-Hyun Yun, Johannes F. de Boer
  • Patent number: 9336354
    Abstract: Systems and methods are disclosed for simulating or optimizing hemodialysis access. One method includes receiving a patient-specific anatomic model of a patient's vasculature; computing a pre-treatment hemodynamic characteristic of a pre-treatment geometry of a portion of the anatomic model; simulating a post-treatment geometry of a vascular access in the portion of the anatomic model; computing a post-treatment hemodynamic characteristic of the post-treatment geometry of the portion of the anatomic model having the vascular access; and generating a representation of the pre-treatment hemodynamic characteristic or the post-treatment hemodynamic characteristic.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: May 10, 2016
    Assignee: HeartFlow, Inc.
    Inventors: Sethuraman Sankaran, Leo J. Grady, Charles A. Taylor, Christopher K. Zarins
  • Patent number: 9301697
    Abstract: Techniques for non-invasive blood pressure monitoring are disclosed. Data corresponding to a patient may be received from a hospital information system. The data may include, for example, drug administration data, medical procedure data, medical equipment data, or a combination thereof. Whether a blood pressure monitoring system needs to be recalibrated may be determined, based at least in part on the received data. If it is determined that the blood pressure monitoring system needs to be recalibrated, the recalibration may be performed and at least one blood pressure measurement of the patient may be computed using the recalibrated blood pressure monitoring system.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: April 5, 2016
    Assignee: Nellcor Puritan Bennett Ireland
    Inventors: Clark R. Baker, Jr., James Nicholas Watson, Paul Stanley Addison
  • Patent number: 9289136
    Abstract: Systems and methods are provided for storing and recalling metrics associated with physiological signals. It may be determined that the value of a monitored physiological metric corresponds to a stored value. In such cases, a patient monitor may determine that a calibration is not desired. In some cases, a patient monitor may recall calibration parameters associated with the stored value if it determined that the stored value corresponds to the monitored metric value.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: March 22, 2016
    Assignee: Nellcor Puritan Bennett Ireland
    Inventors: Paul Stanley Addison, James N. Watson
  • Patent number: 9241646
    Abstract: A PPG system for determining a stroke volume of a patient includes a PPG sensor configured to be secured to an anatomical portion of the patient. The PPG sensor is configured to sense a physiological characteristic of the patient. The PPG system may include a monitor operatively connected to the PPG sensor. The monitor receives a PPG signal from the PPG sensor. The monitor includes a pulse trending module determining a slope transit time of an upslope of a primary peak of the PPG signal. The pulse trending module determines a stroke volume of the patient as a function of the slope transit time.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: January 26, 2016
    Assignee: Covidien LP
    Inventors: Paul Stanley Addison, James Nicholas Watson
  • Patent number: 9234842
    Abstract: The apparatus enables biometric authentication without the risk of forgery or the like and enables living-tissue discrimination. The roughness distribution pattern of deep-layer tissue of the skin covered with epidermal tissue is detected, thereby extracting a unique pattern of the living tissue. Biometric authentication is performed based upon the detected pattern. The roughness distribution pattern of the deep-layer tissue of the skin is optically detected using difference in optical properties between the epidermal tissue and the deep-layer tissue of the skin. Long-wavelength light, e.g., near-infrared light, is used as illumination light cast onto the skin tissue. A fork structure of a subcutaneous blood vessel is used as the portion which is to be detected, for example. The portion which is to be detected is determined based upon the structure of the fork structure. The living-tissue discrimination may be made using the subcutaneous blood vessel.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: January 12, 2016
    Assignee: Sony Corporation
    Inventor: Kiyoaki Takiguchi
  • Patent number: 9204808
    Abstract: A device for monitoring the efficiency of physical training in a human or animal includes a millimeter wave generator that generates millimeter wave radiation and a millimeter wave antenna that emits millimeter waves generated by the millimeter wave generator in a predetermined direction. The device includes a coupling element that couples the millimeter wave antenna to the millimeter wave generator and that transmits the millimeter wave radiation to the millimeter wave antenna. The device also includes a reference element that intermittently receives millimeter wave radiation from the millimeter wave antenna and a detector that detects millimeter wave radiation and produces a first data stream. The device further includes a processing unit that receives the first data stream and generates a signal indicating development of a body lactate level over time and an output device indicating the development of the body lactate level over time, to a user.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: December 8, 2015
    Inventor: Matthias Riedel
  • Patent number: 9186090
    Abstract: The present invention can provide a system and method for DLCO quality control testing and can include an apparatus for testing a pulmonary diagnostic device capable of performing single breath carbon monoxide uptake measurement, comprising: a single gas-tight chamber, with a gas port configured to receive gas from or to expel gas to the exterior of the chamber and a partition configured to change the volume of the single gas-tight chamber; the single gas-tight chamber capable of expanding and contracting; a member disposed within the single gas-tight chamber and configured to limit the movement of the partition, the member being adjustable to set a predetermined maximum volume of the single gas-tight chamber and a predetermined volume of DLCO test gas that the single gas-tight chamber can receive; and an interface configured for the transfer of gas between the pulmonary diagnostic device and the simulation device via the gas port.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: November 17, 2015
    Assignee: nSpire Health, Inc.
    Inventors: Edmond Chu, Eric Norgard, William Chase Wallace
  • Patent number: 9149199
    Abstract: An implantable device and method for monitoring changes in the risk of arrhythmia induced by medications. The implantable device monitors risk of arrhythmia by analyzing an aspect of T-wave morphology to generate a metric of transmural dispersion of repolarization (“TDR”) as a proxy for the risk of arrhythmia. The implantable device generates an index of change in the risk of arrhythmia by comparing values of the metric of TDR obtained for different time periods. The implantable device generates a warning if the change in risk of arrhythmia is outside acceptable limits. The implantable device can also communicate with other devices to correlate changes in risk of arrhythmia with medications taken by the patient.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: October 6, 2015
    Assignee: Pacesetter, Inc.
    Inventor: Taraneh Ghaffari Farazi
  • Patent number: 9119535
    Abstract: A blood pressure measurement device accurately calculates an index useful in determining the degree of arteriosclerosis by accurately detecting a difference in time of appearance of a ejection wave and reflected wave in a blood pressure waveform. The device sets a threshold value based on an index that expresses a characteristic of the blood pressure waveform with respect to the point of appearance of the reflected wave in the blood pressure and estimates a rise point of the reflected wave by calculating an x-coordinate value of a point based on a maximum amplitude of the reflected wave and the threshold value. The device obtains the index of degree of arteriosclerosis by calculating a time difference in appearance between the ejection wave and the reflected wave based on the estimated rise point of the reflected wave.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: September 1, 2015
    Assignee: OMRON HEALTHCARE Co., Ltd.
    Inventors: Kenji Fujii, Tatsuya Kobayashi, Toshihiko Ogura
  • Patent number: 9113793
    Abstract: Among the technical characteristics disclosed in this specification, the pulse wave sensor with one of the technical characteristic includes a construction to detect the pulse wave at a wrist (i.e., a construction to measure the pulse wave to be worn at the wrist). To be more concrete, the pulse wave sensor includes a measurement unit to measure the pulse wave, a power source unit to supply power to the measurement unit, a cable to connect between the measurement unit and the power source unit electrically, and a armlet type housing to contain the measurement unit, the power source unit, and the cable.
    Type: Grant
    Filed: November 14, 2011
    Date of Patent: August 25, 2015
    Assignee: Rohm Co., Ltd.
    Inventors: Koji Terumoto, Daisuke Niwa, Tsuyoshi Satomi, Kazuhiro Oguchi
  • Patent number: 9113797
    Abstract: The blood vessel characteristics measuring apparatus 100 includes a blood flow measuring unit 20 held at a position opposed to a skin surface 10 of a measurement region of a subject, an optical sensor unit 30 housed in the blood flow measuring unit 20, an electrocardiograph 40, and a controller 50. The controller 50 includes a blood flow measuring part 60, a blood vessel displacement deriving part 70, and a blood vessel condition deriving part 80. The blood flow measuring part 60 measures the displacements of a blood vessel and tissues around the blood vessel caused by a blood flow based on light intensity at the time of receiving light emitted from a light-emitting part 32 of the sensor unit 30 in light-receiving parts 34 and 36. The blood vessel displacement deriving part 70 derives the wall of the blood vessel 12 based on the displacements of the blood vessel and tissues around the blood vessel.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: August 25, 2015
    Assignee: University of Tsukuba
    Inventor: Yoshiyuki Sankai
  • Patent number: 9102220
    Abstract: Arrangement for a vehicle including a sensor system arranged on the vehicle for sensing an event requiring an emergency response, a location determining device for determining the location of the vehicle, a communication device arranged on the vehicle for automatically communicating to a remote location when an event has occurred that the event has occurred and providing the remote location with the determined location of the vehicle, and a power source for providing power for the sensor system, the location determining device and the communication device. The communication device communicates to the remote location upon occurrence of the event. The location determining device may be arranged partially or entirely on the vehicle or elsewhere. The remote location may be an emergency response center which can direct aid to the vehicle's location.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: August 11, 2015
    Inventor: David S. Breed
  • Patent number: 9095309
    Abstract: An apparatus for quantifying contrast agent behavior of an administrated contrast agent within a region of interest, comprises an imaging device configured to acquire images of a subject and processing structure communicating with the imaging device. The processing structure is configured to process image data of the acquired images to yield a time sequence of images, I(t), at a location (I) outside of the region of interest that detect contrast agent concentration before the contrast agent enters the region of interest and to yield a time sequence of images, J(t), at a location (J) within the region of interest that detect the contrast agent concentration as the contrast agent perfuses the region of interest.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: August 4, 2015
    Assignee: Multi Magnetics Incorporated
    Inventors: Robert Z. Stodilka, Frank S. Prato
  • Patent number: 9037208
    Abstract: A system and method for monitoring a health condition are disclosed. The system includes a patient management application, a data store and a monitoring device. The monitoring device includes an optical sensor, a Doppler sensor, and a computing device adapted to provide health parameter values including oxygen saturation of the blood, blood flow, blood pressure, heart rate, and cardiac output.
    Type: Grant
    Filed: May 12, 2008
    Date of Patent: May 19, 2015
    Assignee: Cardio Art Technologies, Ltd.
    Inventor: Dan Gur Furman
  • Patent number: 9031640
    Abstract: [Subject] To provide laser Doppler blood flow measuring method and device which achieve multi-dimensional measurement efficiently at a high degree of accuracy over a wide range with a simple optical system and device. [Solving Means] Laser light from a semiconductor laser 12 is split and formed into sheet lights Ls using a cylindrical lens 22, and the sheet lights Ls are crossed with each other at a predetermined position. A lens system 30 configured to form an image of scattered lights into a linear shape at a linear irradiation site Lx where the sheet lights Ls cross with each other is provided. An optical fiber array 32 having a plurality of optical fibers 34 is provided at an image-forming position of the lens system 30. Avalanche photodiodes 42 configured to convert the scattered lights which are shifted in frequency by the Doppler effect caused by the blood flow into electric signals for the each optical fiber 34 are provided.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: May 12, 2015
    Assignees: Institute of National Colleges of Technology, Japan, National Univeristy Corporation of Toyama
    Inventors: Tadashi Hachiga, Hiroki Ishida, Shunsuke Akiguchi, Hiroki Shirakawa, Tsugunobu Andoh, Yasushi Kuraishi