Abstract: A method and apparatus for determining cardiac output in conjunction with flow through an extracorporeal circuit, wherein flow through an arterial line of the extracorporeal circuit is temporarily reversed and an indicator is passed through the cardiopulmonary circuit. A dilution curve is measured in the arterial line of the extracorporeal circuit during the reversed flow, and cardiac output is determined corresponding to the measured dilution curve.

Abstract: Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.

Abstract: A human condition evaluation system, of which bio-signal analysis means includes a bio-signal peak value detection means for detecting a peak value for each cycle of an original waveform of a bio-signal data, and a power value calculation means for calculating a difference between the peak value at an upper limit side and the peak value at a lower limit side for every prescribed time range using respective peak values obtained by the bio-signal peak value detection means to thereby set the difference as a power value, is structured to determine a predictive signal for falling asleep from an active state into a sleep state. Different from conventional human condition evalution based simply on a Lyapunov exponent as an indicator, a new human condition evaluation system based on a functional status of an energy generation system of the living body is provided.

Abstract: A monitoring device, method and system are disclosed herein. The monitoring device is capable of determine when a user's wrist is at rest using a motion sensor disposed within a wrist module that is attached to the user's wrist. When at rest, the monitoring device utilizes a vital sign monitor to determine a plurality of vital signs of the user. The vital sign monitor preferably comprises a light source and photodetector in communication with a pulse-oximetry circuit. The motion sensor is preferably an accelerometer.

Abstract: The invention provides devices, systems and methods for occluding arteries without puncturing skin or vessel walls. The devices, systems and methods for occluding arteries are configured to be applied to arteries externally of the arteries. Occlusion may be temporary or permanent, and may be partial or complete. Clamping a device to tissue near to an artery is effective to compress tissue around the artery and to indirectly compress the artery. The methods, devices and systems of the invention find use in, for example, treatment of uterine disorders and conditions which may be treated by occlusion of the uterine arteries. A uterine artery may be accessed via a patient's vagina by compressing a portion of the vaginal wall around a portion of a uterine artery to occlude a uterine artery. Clamping of an artery may also be performed by clamping a device directly onto an artery.

Abstract: A method and a device are used for determining a characteristic value for the perfusion of modified, in particular pigmented tissue regions in organs of living beings, for example the skin. By means of a laser flowmeter, a first volumetric flow rate and a second volumetric flow rate of the blood are determined at a first measurement point and at a second measurement point, respectively within the modified tissue region and within the surrounding, unmodified tissue region, in each case as a measurement profile of a volumetric flow rate signal as a function of time. A wavelet analysis of each of the measurement profiles is then carried out as a three-dimensional representation of the signal intensity over a frequency or scaling axis and time.

Abstract: The microwave hemorrhagic stroke detector includes a low power pulsed microwave transmitter with a broad-band antenna for producing a directional beam of microwaves, an index of refraction matching cap placed over the patients head, and an array of broad-band microwave receivers with collection antennae. The system of microwave transmitter and receivers are scanned around, and can also be positioned up and down the axis of the patients head. The microwave hemorrhagic stroke detector is a completely non-invasive device designed to detect and localize blood pooling and clots or to measure blood flow within the head or body. The device is based on low power pulsed microwave technology combined with specialized antennas and tomographic methods. The system can be used for rapid, non-invasive detection of blood pooling such as occurs with hemorrhagic stoke in human or animal patients as well as for the detection of hemorrhage within a patient's body.

Abstract: A system for the determination of quantifies relating to the circulatory system of a patient including a device for the non-invasive measurement of the qualitative variation over time of the local concentration of an indicator injected into the blood circulation system at a first position, the measurement taking place at a second position of the blood circulation system. An evaluating unit is provided, in which there is implemented an evaluating algorithm which transforms the qualitative variation into a quantitative variation over time of the local concentration of the indicator injected into the blood circulation system. For the purposes of the transformation, the condition is fulfilled that the cardiac output COdye calculable from the quantitative variation over time of the local concentration in accordance with a predetermined relationship is equal to an input value of the cardiac output COe, which has been determined by thermodilution measurement.

Abstract: In a method for determining the effectiveness of a therapy for alleviating a constriction in a blood vessel, the functioning of collateral vessels naturally formed at the constriction is analyzed. The analysis takes place by making a blood flow measurement at the vessel in which the constriction is present, or at a complementary vessel, with the patient experiencing two different stress conditions. The flow measurement can ensue by magnetic resonance or using ultrasound. Comparison of the stress-dependent blood flow to a reference is then undertaken to determine whether the collateral vessels are functioning effectively, and thus whether the treatment for alleviating the constriction is effective.

Abstract: The invention relates to methods, apparatus, articles-of-manufacture, and coded data signals for measuring cardiac output, limb blood flow, perfusion, blood pressure, artery elasticity, and cardiovascular deterioration and disease, including performing these measurements on a continuous heart beat-by-beat basis, for humans and animals. Unlike empirical methods of other noninvasive blood pressure concepts, the invention is grounded on scientifically appropriate hemodynamic principles that studies have validated as accurate, and is practical for wide clinical use. Devices constructed in accordance with the invention can be comfortably employed for numerous applications, including hospital monitoring, physician's office cardiovascular disease management and drug therapy monitoring, home monitoring, and athletic applications.

Abstract: Doppler Velocimetry is a widely used method for estimating stroke volume (SV). The accuracy and reliability of its measurement however, is dependant on a) the correct assessment of the aortic valve cross-sectional area (CSA), and b) the maximal systolic velocity integral (SVI). The invention avoids the conventional assessment of aortic valve CSA by using a calibration method: a reference stroke volume SVREF is determined by a method different from Doppler velocimetry, e.g. by thoracic electrical bioimpedance (TEB), or thoracic electrical bioadmittance, measured via surface thorax electrodes (transthoracic approach) or via electrodes located directly on an esophageal catheter/probe (esophageal approach). In the latter case, if esophageal Doppler velocimetry is used, the same catheter can be used for the placement of the electrodes and for an ultrasound transducer.

Abstract: The invention provides a device that measures a patient's blood pressure without using an inflatable cuff. The device includes an optical module featuring an optical source and a first optical sensor that generates a first set of information; a flexible, thin-film pressure sensor that generates a second set of information; and a processing module, configured to receive and process the first and second sets of information to calculate a time-dependent blood pressure value.

Abstract: A pump system includes an implantable pump including a motor having a rotor and a stator. The stator includes a plurality of stator windings, and a motor controller is coupled to the motor to energize the windings so as cause the rotor to turn. A time-based system parameter of the pump is sampled and the system parameter is analyzed to calculate a suction probability index that provides an indication of the imminence of ventricle collapse.

Abstract: Multi-channel blind system identification is utilized to identify a patient's cardiac functions without catheterization. The approach is adaptive to each patient's cardiovascular system variations. The cardiac functions can be determined by formulating an auto-regression moving average model utilizing either finite impulse response systems or a group of infinite impulse response systems. Both of these models identify the system functions by solving a set of linear equations using the least-squares method. The system input is then identified by deconvolving the system output and the estimated impulse response of each channel. These models can be augmented to obtain an estimate of the maximum order of the cardiac functions when they are unknown a priori. The approach can also be modified to obtain the cardiac functions by first resolving the distinct dynamics associated with each channel, then determining the common dynamics and ultimately determining the system input.

Abstract: Methods, apparatuses, media and signals for evaluating a vessel. One method includes receiving at least one measurement of a physical dimension of the vessel, and producing an indication of abnormality in the vessel, in response to the at least one received measurement and at least one population-based parameter for the vessel. Producing may include producing an indication of stenosis of the vessel, in response to the physical dimension measurement and a population-based reference dimension for the vessel. This may include producing a population-based percent stenosis value in response to a ratio of the physical dimension measurement to the population-based reference dimension. Producing may further include identifying a shape characteristic of the vessel, which may include producing a tapering comparison value in response to the tapering of the vessel and a population-based average tapering value. The vessel may include a coronary artery segment, for example.

Abstract: A method of analyzing biological pressure signals in a patient including obtaining arterial blood pressure, cerebral blood flow rate and intracranial pressure signals from the patient, and analyzing frequencies of the signals in relation to a range of target frequencies corresponding to at least one of type-B slow waves, infra-B waves and ultra-B waves; and an apparatus for analyzing biological pressure signals in a patient including an acquisition module, located adjacent to the patient and having input channels that receive signals from an arterial blood pressure (ABP) sensor, a cerebral blood flow rate (CBF) sensor, and an intracranial pressure (ICP) sensor; an analysis module that performs frequency analysis of the signals from a target frequency selected from the group consisting of type B slow waves corresponding to a frequency between 8×10?3 hertz and 50×10?3 hertz, infra-B waves corresponding to a frequency lower than 8×10?3 hertz, and ultra-B waves corresponding to a frequency including between 50×10

Abstract: Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.

Abstract: A plethysmographic or other signal is autocorrelated to give a first-pass determination of the distances among individual waveforms. A waveform is isolated, tested to determine whether its amplitude remains in suitable bounds for signal averaging, and convolved with the signal to match it with the other waveforms for averaging. Thus, a separate gating signal is not needed for signal averaging.

Abstract: A blood rheology measuring apparatus has a measuring portion for measuring blood circulation information inside of a living body from outside of the living body. The blood circulation information is a maximum blood flow velocity for one pulse. An information processing portion processes the measured information from the measuring portion to obtain information concerning a blood rheology of the living body.

Abstract: A differential Fick technique including a first phase in which baseline breathing parameters may be established and a second phase in which a change in the effective ventilation of a patient is induced. The durations of the first and second phases may be substantially the same and may be abbreviated relative to the durations of comparable phases of previously known differential Fick techniques. The disclosed differential Fick technique also lacks a recovery period in which the respiratory parameters of a patient are permitted to return to “normal” levels.

Abstract: A system and method for artifact reduction in thermodilution for cardiac measurement is provided by both respiration artifacts and noise artifacts are reduced. The system and method detects the beginning of a respiration cycle and estimates a respiration artifact which is subtracted from the thermosignal recorded.

Abstract: A sensor part of a blood flowmeter for measuring a value on blood flow in tissue of a living body is provided, in which the sensor part includes: a light emitter for emitting light to tissue of a living body; and a light detector for receiving scattered light from the tissue; a first shading block for preventing light emitted from the light emitter from directly entering the light detector; a second shading block having a predetermined gap in front of the light detector, wherein the light emitter, the light detector and the shading blocks are integrated on a semiconductor substrate.

Abstract: Apparatus for monitoring a plurality of tissue viability parameters of a tissue layer element, in which two different illumination sources are used via a common illumination element in contact with the tissue. One illumination source is used for monitoring blood flow rate and optionally flavoprotein concentration, and collection fibers are provided to receive the appropriate radiation from the tissue. The other illuminating radiation is used for monitoring any one of and preferably all of NADH, blood volume and blood oxygenation state of the tissue element, and collection fibers are provided to receive the appropriate radiation from the tissue. In one embodiment, the wavelengths of the two illumination sources are similar, and common collection fibers for the two illuminating radiations are used. In another embodiment, the respective collection fibers are distanced from the illumination point at different distances correlated to the ratio of the first and second illuminating wavelengths.

Abstract: The invention relates to systems and methods for assessing blood flow in single or multiple vessels and segments, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for effect, for assessing risk factors, for evaluating intracranial pressure and for analyzing the results in a defined manner. The invention enables direct monitoring of therapies, substances and devices on blood vessels, especially those of the cerebral vasculature. Relevant blood flow parameters include mean flow velocity, systolic acceleration, and pulsatility index. Measurement and analysis of these parameters, and others, provides details regarding the vascular health of individual and multiple vessels and a global analysis of an individual's overall vascular health.

Abstract: Heat exchanger-equipped catheters and related methods that are useable for changing or maintaining at least a portion of the body of a human or veterinary patient at a desired temperature and for the measurement of cardiac output or blood flow rate within a blood vessel, without the need for introduction of saline solution or any other foreign substance into the patient's blood.

Abstract: A vascular shunt apparatus (10) includes a tubular member having first and second end portions (16, 20) and an aperture extending through the first and second end portions (16, 20). A transducer (64) can be associated with the tubular member to provide a signal in response to the flow of fluid through the tubular member. One or both of the end portions (16, 20) also can be adapted to form respective sealing connections with different parts of a patient's vascular system.

Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.

Abstract: An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter by measuring a non-calibrated value of the parameter non-invasively, and inducing a stress of the circulatory system while measuring a second parameter. The response of the circulatory system to the stress is determined directly from the subject, and a calibration function is derived from the response and applied to the non-calibrated measured value to produce a calibrated measure of the actual value of the hemodynamic parameter. Methods of using backscattered acoustic energy for determination of hemodynamic markers are also disclosed.

Abstract: A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.

Abstract: A blood flow measuring apparatus has a measuring electrode and a counter-electrode adapted to be brought into contact with the blood of a patient. A measuring unit measures a voltage or a current between the measuring electrode and the counter-electrode and determines the flow of blood therefrom. The measuring electrode is ring-shaped and sized to fit within a blood vessel in the body of the patient. An inner surface of the ring-shaped electrode forms an active measuring electrode surface. The blood flow measuring apparatus is suitable for use in a cardiac pacemaker.

Abstract: A monitoring device (10), method and system are disclosed herein. The monitoring device (10) utilizes a vital sign monitor (16) to determine a plurality of vital signs of the user. The vital sign monitor (16) preferably comprises a light source (3) and photodetector (31) in communication with a pulse oximetry circuit (35).

Abstract: An arteriosclerosis detection system including an electrocardiographic signal detection device, an eyeground image detection device for detecting an eyeground image in synchronization with an electrocardiographic signal detected by the detection device. The arteriosclerosis detection system further includes an eyeground vein constriction detection device for detecting the constriction of an eyeground vein in the vicinity of a site at which the eyeground vein and an eyeground artery cross each other. The constriction is detected based on the detected eyeground image in synchronization with the electrocardiographic signal. The arteriosclerosis detection system detects the eyeground image by executing an algorithm of software, which provides an eyeground image synchronized with an electrocardiographic signal by obtaining a stationary eyeground image synchronized with an arbitrary electrocardiographic signal from an animated eyeground image.

Abstract: An apparatus for assessing cardiovascular status of a mammal comprises a system for locally applying a pressure to an artery capable of restricting blood flow through said artery, a wideband external pulse transducer having an output and situated to measure suprasystolic signals proximate to said artery, and a computing device receiving said output for calculating vascular compliance values. The method described is particularly useful for determining cardiac output, assessing whether a pregnant female has preeclampsia or a patient has cardiac insufficiency, or assessing cardiac arrhythmias.

Abstract: A method and apparatus for determining an angioplasty induced blood flow changes, wherein the apparatus includes the catheter having a port for introducing a blood property change in a downstream sensor. The downstream sensor and the catheter are configured to space the sensor from an adjacent vessel wall so as to minimize effects of the vessel wall during sensing of the blood property change.

Abstract: An arteriostenosis diagnosing apparatus which measures an ankle blood pressure at an ankle 12 of a patient and a brachium blood pressure at a brachium 14, so that the measured ankle and brachium blood pressure values are used to calculate an ankle and brachium blood pressure index ABI, and additionally measures a first pulse wave propagation velocity PWV1 with respect to the ankle 12 as a first measuring point and the brachium 14 as a second measuring point, and a second pulse wave propagation velocity PWV2 with respect to the patient's heart and the brachium 14.

Abstract: A biological data observation apparatus includes a measuring unit including at least a photoelectric sensor including a light emitting element for emitting light with a predetermined wavelength onto a blood vessel of a subject and a light detecting element for detecting, as a photoelectric volume pulse wave, a change in an amount of transmitted or reflected light resulting from the light emitted from the light emitting section, a storage area in which pressure conversion data correlating a pulse wave area and a blood pressure value in order that the pulse wave area may be converted to the blood pressure value as an absolute value, the pulse wave area being obtained by integrating a wave form of the photoelectric capacity pulse wave per heartbeat, an operational unit calculating the pulse wave area on the basis of the photoelectric volume pulse wave obtained from the subject and further calculating the blood pressure value of the subject on the basis of the calculated pulse wave area and the blood pressure con

Abstract: Methodology for determining the bounds of a patient's acoustic window is described. Medical application acoustic array designs with apertures accommodated by patient acoustic windows and merged acoustic windows are exemplified.

Abstract: A method and apparatus for non-invasively evaluating endothelial activity in a patient, particularly for indicating the presence of an endothelial dysfunction condition, by applying an occluding pressure to a predetermined part of an arm or leg of the patient to occlude arterial blood flow therein; maintaining the occluding pressure for a predetermined time period; removing the occluding pressure after the elapse of the predetermined time period to restore arterial blood flow; monitoring a digit of the arm or leg by a digit-probe for changes in the peripheral arterial tone therein before and after the application of the occluding pressure to the arm or leg of the patient; and utilizing any detected changes in the peripheral arterial tone for evaluating endothelial activity in the patient.

Abstract: The present invention relates to a method and apparatus for monitoring haemodynamic function in animals and humans during anaesthesia and surgery. During anaesthesia and surgery the subject's haemodynamic, respiratory, neuromuscular and neurological functions are monitored as indicators of the condition of the health of the subject. Commonly, variations in blood pressure are used to imply corresponding variations in cardiac output, i.e. good blood pressure equals good cardiac output. The present invention utilizes a device to monitor changes of blood flow in peripheral blood vessels of the subject as an indicator of cardiac output. This is believed to provide a much more accurate indicator.

Abstract: In a clinical and physiological abnormality monitoring apparatus, and blood pressure monitoring apparatus detects a blood pressure abnormality and the like of a body by employing a pulse wave signal. A frequency analysis is carried out with respect to a pulse wave signal, while this pulse wave signal corresponds to time sequential data of pulse waves. As a result, both a C-frequency component indicative of a fluctuation component of a base line of the pulse wave signal, and also an A-frequency component representative of the respective pulse waves are acquired. A ratio C/A of power of a peak contained in the C-frequency component with respect to power of a peak contained in the A-frequency component is calculated to determine abnormality of the blood pressure.

Abstract: A sensing apparatus with a connector, a sensor lead and a sensor module with a spacer placed over electrodes that have been deposited on a substrate. The spacer may have a space for receiving an enzyme. End portions of the sensor module may be encapsulated, such as with molded beads. A sensor lead may attach to the sensor module and may have an outer tubing that passes over the module and attaches to the beads at the end of the sensor module. The sensor lead may also attach to the connector such that the sensing apparatus may be electrically coupled to a pump, electronics or other devices. The sensing apparatus may be implanted into a vein or artery.

Abstract: A system is provided for compressing one or both of the uterine arteries of a patient which is at least in part shaped to complement the shape of the exterior of the cervix, which allows the system to be self-positioning. One or more Doppler chips can be mounted or incorporated into the system which permit the practitioner to better identify the uterine artery and monitor blood flow therein. The system includes a pair of pivotally joined elements which can be moved toward and away from the cervix to compress a uterine artery.

Abstract: Methods and systems for providing mobile subscriber surveillance identify certain call signaling messages as candidate messages for mobile subscriber surveillance. From the candidate messages, messages associated with mobile subscribers under surveillance are identified. Mobile subscriber location information is obtained for the messages associated with the mobile subscribers under surveillance. The location information is forwarded to a surveillance center, such as a state or federal law enforcement or security agency. The original call signaling messages are forwarded to their intended destinations so that surveillance is performed transparently to the mobile subscriber under surveillance.

Abstract: An apparatus for diagnosing an angiopathy of a living subject, including a first pulse-wave-propagation-velocity-related-information obtaining device which obtains a first pulse-wave-propagation-velocity-related information that is related to a first velocity at which a first pulse wave propagates through a first interval of the subject, a second pulse-wave-propagation-velocity-related-information obtaining device which obtains, at a substantially same time as a time when the first pulse-wave-propagation-velocity-related-information obtaining device obtains the first pulse-wave-propagation-velocity-related information, a second pulse-wave-propagation-velocity-related information that is related to a second velocity at which a second pulse wave propagates through a second interval of the subject that is different from the first interval, and a comparison-value calculating device for calculating a comparison value based on the first pulse-wave-propagation-velocity-related information and the second pulse-wave-p

Abstract: An apparatus for determining a standard pulse-wave-propagation-velocity-related value for a living subject, comprising: a blood-pressure measuring device for measuring a blood pressure of the subject; an age determining device for determining an age of the subject; and a standard-pulse-wave-propagation-velocity-related-value determining device for determining the standard pulse-wave-propagation-velocity-related value for the subject, based on the blood pressure of the subject measured by the blood-pressure measuring device and the age of the subject determined by the age determining device, according to a predetermined relationship between (A) (a1) blood pressure and (a2) age and (B) standard pulse-wave-propagation-velocity-related value.

Abstract: The present invention relates to a method of and a system for treating a health condition of a user. The method includes determining a sensory signal for use to treat the user's health condition, measuring the change to the sensory signal while the user is engaging in an activity, and using the sensory signal change to regulate the user's activity to thereby treat the user's health condition. The system has a sensor device for measuring a sensory signal of the user while the user is engaging in an activity and a display device receiving the sensory signal measured by the sensor device and displaying the sensory signal. The change to the sensory signal is used to regulate the user's activity to thereby treat the user's health condition.

Abstract: Thermal image data of at least a region of a face of a person is provided. The thermal image data is transformed to blood flow rate data and may be used to determine whether the person is deceptive or non-deceptive based on the blood flow rate data, e.g., deceptive with respect to an elicited response from the person.

Abstract: A heart-sound detecting apparatus, including: a heart-sound microphone which detects a plurality of heart sounds produced by a heart of a living subject and outputs a heart-sound signal representative of the detected heart sounds; a smoothing device for smoothing, by differentiation, a waveform of the heart-sound signal output from the heart-sound microphone; a squaring device for squaring an amplitude of the smoothed waveform with respect to a base line of the heart-sound signal; and a start-point determining device for determining a start point of a first heart sound I as one of the detected heart sounds, based on that the squared amplitude is greater than a prescribed threshold value.

Abstract: A method of data management for optimizing the patient outcome from the provision of external counterpulsation (ECP) therapy is described. This method describes a process by which sets of dynamic cardiopulmonary dependent variables are measured during steady-state conditions, displayed, and translated into quantitative and qualitative measurements while the independent variables of ECP, cuff inflation duration and cuff inflation pressure settings of ECP systems, are altered by a physician. In combination with visual observation and computer-assisted ranking of the dependent variables, a physician can utilize the resulting information to render decisions on the optimal choice of the independent variables. The method will enable physicians to collect, view, track and manage complicated data using well-understood visualization techniques to better understand the consequences, acutely and chronically, of their therapeutic actions in general, and of their provision of ECP therapy in particular.

Abstract: A sphygmogram measure method and device, which detects pulse pressure and blood flow rate simultaneously, includes an upstream and a downstream pressure sensors provided to measure the pulse pressure of two adjacent points on radial artery. The time lag of pulse wave passing through the two pressure sensors is obtained by a time delay detection circuit. The values of pulse pressure at the upstream pressure sensor and time lag are inputted into a digital signal process unit for calculating the value of pulse pressure at the downstream pressure sensor. A thermal image device and an optical displacement sensor are used to measure the unstressed vessel's diameter and the variation of vessel's diameter. A viscometer measures the blood viscosity coefficient of blood specimen. All the values above are used to calculate vessel compliance and blood flow rate as a helpful reference of human's health status.