Abstract: When monitoring a patient, acoustic events (e.g., coughs, snores, impact sounds, verbalizations, etc.) relevant to the patient's status are detected by a microphone array (12) and timestamped. Detected event signals generated by the microphone array (12) are filtered to identify signatures such as zero crossings, corner frequencies, amplitude, pitch, etc., for classification purposes. The filtered signals are digitized and classified into one of a plurality of acoustic event classes (e.g., snore, cough, wheeze, breath, etc.) and/or subclasses. The classified events are displayed to a user (e.g., graphically, textually, etc.) with their timestamps to indicate chronology. A user can review the acoustic events, select one or more events, and listen to a recording of the selected event (s). Additionally, specified acoustic events can trigger an alarm to alert a nurse or the like that the patient requires immediate attention.

Abstract: A method and system for sleep apnea detection are disclosed. The method comprises detecting at least one respiratory signal and utilizing a detection algorithm to automatically detect at least one sleep apnea event from the at least one respiratory signal. The system includes a sensor to determine at least one respiratory signal, a processor coupled to the sensor, and a memory device coupled to the processor, wherein the memory device includes a detection algorithm and an application that, when executed by the processor, causes the processor to utilize the detection algorithm to automatically determine at least one sleep apnea event from the at least one respiratory signal.

Abstract: A method for determining blood pressure is disclosed. The method comprises determining a plurality of heart sounds using a microphone of a handheld device and determining a pulse wave using a camera of the handheld device. The method includes determining an ejection time (ET), a vascular transit time (VTT), and a heart rate from any of the plurality of heart sounds and the pulse wave. The method includes performing regression analysis on received user-specific data, the ET, the VTT, and the heart rate to determine the blood pressure.

Abstract: The invention features a vital sign monitor that includes: 1) a hardware control component featuring a microprocessor that operates as interactive, icon-driven GUI on an LCD; and, 2) a sensor component that connects to the control component through a shielded coaxial cable. The sensor features: 1) an optical component that generates a first signal; 2) a plurality electrical components (e.g. electrodes) that generate a second signal; and, 3) an acoustic component that generates a third signal. The microprocessor runs compiled computer code that operates: 1) the touch panel LCD; 2) a graphical user interface that includes multiple icons corresponding to different software operations; 3) a file-management system for storing and retrieving vital sign information; and 4) USB and short-range wireless systems for transferring data to and from the device to a PC.

Abstract: Systems and methods for detecting events indicative of worsening using heart sounds are disclosed. A system can include a signal sensor circuit to sense a heart sound (HS) signal. The system can detect at least first and different second HS components using the HS signal, and generate respective first and second HS metrics. The system can determine a trend indicator for the first or second HS metric, and selectively generate one or more composite HS metrics using the first and second HS metrics, according to the trend indicator indicating a growing or decay trend. The system can include a heart failure (HF) event detector to produce a HF status using the composite HS metrics, and output an indication of the HF status, or deliver therapy according to the HF status.

Abstract: An electrical system controlled, driven by and/or based on naturally occurring electrophysiological signals in a patient's body is used to produce useful electromagnetic fields for health applications and/or medical applications provided to the patient.

Abstract: A system comprises a risk analysis module and a worsening heart failure (WHF) detection module. The risk analysis module measures at least one first physiological parameter of a subject using a physiological sensor of an ambulatory medical device, and determines a heart failure (HF) risk score for the subject according to the at least one measured first physiological parameter. The HF risk score indicates susceptibility of the subject to experiencing a HF event. The WHF detection module measures at least one second physiological parameter of the subject using the same or different physiological sensor, and generates an indication of prediction that the subject will experience a WHF event when the at least one second physiological parameter satisfies a WHF detection algorithm. The risk analysis module adjusts generation of the indication by the WHF detection algorithm according to the determined HF risk score.

Abstract: A stethoscope system may include an array of sensors, which may include pressure sensors. The array may be implemented in a wearable “patch” that is conformable to a patient's body. The stethoscope system may include a control system that is capable of receiving signals from the array of sensors. The signals may, for example, correspond to measurements from multiple pressure sensors of the array. The control system may be capable of combining signals from multiple pressure sensors to produce combined signals. The control system may be capable of filtering the combined signals to remove, at least in part, breathing signal components and to produce filtered signals. The control system may be capable of determining a correspondence between heart signal components of the filtered signals and corresponding heart valve activity.

Abstract: A method and device (10) are provided for monitoring regular movement of the body (20) of a human subject, such as an infant. The device (10) includes electronic circuitry, an alarm and attachment means (14) for attaching to the subject's body (18), a first non-contact proximity sensor (22), and a second proximity sensor. When the device (10) is attached to the subject's body, the two proximity sensors (22,24) monitor movement of the subject's body in two sensor zones a first sensor zone (23) and a second sensor zone (25) that is father from the device than the first sensor zone (23). If a pattern in the distances monitored in either sensor (22,24) changes by a predetermined extent, that alarm is activated.

Abstract: A medium voltage connection has: a first conductor and a second conductor electrically attached to each other; a first isolating layer arranged around the first conductor and a second isolating layer arranged around the second conductor, leaving an air gap between both isolating layers; an isolating rubber sleeve arranged between the first isolating layer and the second isolating layer to fill the air gap between the two isolating layers. A conducting layer is arranged on the first isolating layer and the rubber sleeve is provided with a conducting portion, which overlaps with the conducting layer.

Abstract: Disclosed herein is an implantable electronic device. The device has a housing and a header connector assembly coupled to the housing. The header connector assembly has a connector assembly and a header enclosing the connector assembly. The connector assembly has a subassembly including an electrically conductive component at least partially residing within a first material that is provided about the electrically conductive component. The header has a second material that is provided about the connector assembly and the subassembly subsequent to the first material setting up about the electrically conductive component.

Abstract: A mounting system is provided to allow the attachment of an acoustic collector to a handheld electronic device such that sound is conducted directly to the device's microphone. A fitted case or band encloses part of the device and includes a tube running from the collector to the device's microphone. In certain embodiments, the tube may be embedded in the case, and a detachable mount may be provided to connect the collector to the case. The collector may be a stethoscope chestpiece, or an open air collector, such as a parabolic collector.

Abstract: An apparatus comprises a cardiac signal sensing circuit configured to sense a plurality of intrinsic cardiac signals using a plurality of cardiac pacing sites, a heart sound sensing circuit, a stimulus circuit configured to provide an electrical cardiac pacing stimulus to the plurality of pacing sites, and a control circuit electrically coupled to the cardiac signal sensing circuit and the stimulus circuit. The control circuit includes a pacing site locating circuit configured to generate an indication of a preferred pacing site as one of a) a subset of the respective cardiac pacing sites selected using the intrinsic ventricular activation time interval value, from which subset the preferred pacing site is selected using the heart sound characteristic value; or b) a subset of the respective cardiac pacing sites selected using the heart sound characteristic value, from which subset the preferred pacing site is selected using the ventricular activation time interval value.

Abstract: A system and method to sense heart sounds with one or more implantable medical devices according to one or more signal processing parameters. The method alters one or more of the parameters as a function of one or more physiologic triggering events. The method then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered signal processing parameters.

Abstract: An ultrasonic emitter can launch an unmodulated ultrasonic carrier signal towards an audio source. The ultrasonic carrier signal, upon being reflected from the audio source, undergoes modulation by the audio source. The modulated ultrasonic signal may then be received by an ultrasonic microphone and demodulated to retrieve the audio. A highly directional microphone system is achieved through the use of the ultrasonic emitter and ultrasonic microphone, where the modulated ultrasonic signal only arises when the audio source is in the ‘beam’ of the ultrasonic carrier signal and the ultrasonic microphone can ignore other potential noise, ambient sound(s), etc.

Abstract: The present invention discloses a heart rate detection method used in an earphone and an earphone capable of detecting heart rate. The method comprises: providing a cavity inside the earphone and installing a microphone in the cavity; a shell of the earphone is provided with a hole at a position where an opening of the cavity clings to, and when the earphone is worn, the cavity and the auricle which the hole clings to form an enclosed space; collecting signals generated by pressure change in the cavity by the microphone when the earphone is worn; and detecting heart rate according to the signals collected by the microphone. According to the technical scheme of the invention, the microphone is placed in the enclosed cavity formed by the cavity in the earphone and the shell of the earphone, which reduces interference of external noises, and reinforces signal information collected by the microphone.

Abstract: Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events, such as events indicative of HF decompensation status, are described. The devices and methods can detect an HF event or predict HF risk using one or more physiologic sensor signals including an electrogram and a heart sound signal. A medical device can use the physiologic signals to calculate one more signal metrics indicative of systolic function of the heart, including relative timing between first and second signal features selected from signal features generated from the electrogram or the heart sound signals. The medical device can detect an HF event using the signal metrics, or use the signal metrics to calculate a composite risk indicator indicative of the likelihood of the patient later developing an event indicative of worsening of HF.

Abstract: Method and apparatuses are described to evaluate a state of health of a coronary artery. Vibrational cardiac data from a transducer is received from a first location. The transducer measures vibration of a surface of a human's body non-invasively. The vibrational cardiac data is processed in a second location to create processed vibrational cardiac data. The processing includes separating an unwanted coronary event from the vibrational cardiac data. The processing further includes performing a time-to-frequency transformation on the vibrational cardiac data from a portion of a diastolic interval within a heart cycle to obtain a vibrational frequency power spectrum estimate. The processing includes evaluating a state of health of the coronary artery using the processed vibrational cardiac data.

Abstract: An audio enhancement system includes a display unit configured to exhibit a waveform corresponding to a microphone signal that is subject to an audio interference. The audio enhancement system also includes an interference reduction unit coupled to the microphone signal and configured to provide a reduction in the audio interference, wherein a reduced audio interference is indicated by the waveform in real time. A microphone signal enhancement method is also provided.

Abstract: Systems and methods for detecting heart failure by monitoring the time-sequence of physiological changes of a subject using a state machine circuit configured to receive information about physiological characteristics of the subject is described. The current state transitions between a first and a second state in response to a first transition trigger. The current state transitions between the second and first states in response to at least one of the expiration of a first timer or ceasing of the first transition trigger. The current state transitions between the second and third states in response to a second transition trigger. The current state transitions between the third and second states in response to at least one of expiration of a second timer or ceasing of the second transition trigger.

Abstract: A system for non-invasively determining an indication of an individual's blood pressure is described. In certain embodiments, the system calculates pulse wave transit time using two acoustic sensors. The system can include a first acoustic sensor configured to monitor heart sounds of the patient corresponding to ventricular systole and diastole and a second acoustic sensor configured to monitor arterial pulse sounds at an arterial location remote from the heart. The system can advantageously calculate a arterial pulse wave transit time (PWTT) that does not include the pre-ejection period time delay. In certain embodiments, the system further includes a processor that calculates the arterial PWTT obtained from the acoustic sensors. The system can use this arterial PWTT to determine whether to trigger an occlusive cuff measurement.

Abstract: A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.

Abstract: Heart sound detection systems and methods can use updated heart sound expectation window functions to detect heart sounds. In an example, an initial heart sound expectation window function that describes a heart sound timing can be a function of a physiologic variable such as heart rate, intrinsic vs. non-intrinsic beat, respiration rate, index of circadian timing, or posture. The function can include at least one characteristic parameter that describes a value of the heart sound timing at a specified value of the physiologic variable. In an example, information about a patient heart sound can be detected and used to update a characteristic parameter of an initial heart sound expectation window function, and an updated heart sound expectation window function can be provided using the updated characteristic parameter.

Abstract: An apparatus, such as a cardiac function management system can detect heart sounds following a sensed transition in physical activity level, such as from an elevated physical activity level to rest. A technique can include systems, methods, machine-readable media, or other techniques that can include identifying a physical activity level transition, receiving a heart sound signal, determining characteristics of the heart sound and subject physiologic activity to provide an indication, such as a heart failure status indication.

Abstract: The present invention is an apparatus for detection of high-frequency heart sounds for diagnosing heart diseases. One embodiment utilizes an accelerometer-based detector that presents a light load to the chest, is sensitive to the desired high frequency range, and provides a quantitative measurement of the quality of the acquired signal. Two pairs of flexible beams, each having piezoelectric transducers on the upper and lower surfaces are supported by a lightweight mechanical structure. The beams are center-loaded so that they respond to the same mechanical energy and will produce identical electrical signals in the absence of noise. Through additional signal processing means the two signals can provide an estimate of the signal-to-noise ratio of the acquired signal. The two signals can also be combined to further improve the signal-to-noise ratio. The invention is designed to be light weight, sensitive to higher frequencies, and to be relatively immune to noise.

Abstract: Method, system and computer program for determining matching between two time series. They use an improved algorithm partially based in Dynamic Time Warping and Information Retrieval techniques, but solving the problems (as computational complexity, memory requirements . . . ) observed in these matching techniques.

Abstract: An electronic stethoscope chestpiece includes a chestpiece housing having an interior space including a cavity extending from a radially enlarged open end to a radially constricted aperture to form a stethoscope bell. The radially enlarged open end and radially constricted aperture have a common radial axis. Another part of the interior space includes a circuit board positioned above the radially constricted aperture that mechanically supports a headphone connector and a sound detector located at the radially constricted aperture. The circuit board includes a first electrical channel adapted to transmit an electrical signal corresponding to sound in the stethoscope bell to a portable electronic device that records sound and a second electrical channel adapted to allow an audio signal transmitted from the portable electronic device to pass to the headphone connector.

Abstract: The current invention provides an endotracheal tube fabricated with an array of electrodes disposed on an inflatable cuff on the tube. The array of electrodes includes multiple sense electrodes and a current electrode. The array of electrodes on the inflatable cuff is applied using a positive displacement dispensing system, such as a MicroPen®. A ground electrode is disposed on the tube approximately midway between the inflatable cuff and the midpoint of the endotracheal tube. The endotracheal tube is partially inserted into a mammalian subject's airway such that when the inflatable cuff is inflated, thereby fixing the tube in position, the array of electrodes is brought into close contact with the tracheal mucosa in relative proximity to the aorta. The endotracheal tube is useful in the measurement of cardiac parameters such as cardiac output.

Abstract: A wireless electronic stethoscope device is disclosed. The wireless electronic stethoscope device includes a pen-shaped main body; a sensor module for data collection; a processor module to coordinate operation of electronic stethoscope modules; a wireless communication module to transmit and receive digital and analog data; a power module including a battery for storing energy; a control module to communicate information and receive operational commands.

Abstract: A device for independently and controllably amplifying components of the heart sound signals without removing any component of the signal by filtering. With such a device all the signal components that carry information are still available and can be useful to a user. Filtering may however be applied to very high frequency signals, compared to the signal of interest, that are totally unrelated to the heart sounds.

Abstract: A process for pre-processing recorded and digitized heart sounds and corresponding digitized ECG signals is provided. The pre-processed signals (203) are suitable for input into an automatic decision support system implemented by means of a diagnostic decision network (205), used for diagnosing and differentiation between normal/functional (206) and pathological (207) heart murmurs, particularly in pediatric patients. The process includes identifying or predicting locations of individual heart beats within the heart sound signal, identifying the positions of the S1 and S2 heart pulses within the respective heart beats, predicting and identifying the locations and durations of the systole and diastole segments of the heart beats (302), determining if segmentation of the heart sound signal is possible based on the selected and isolated heart beats (305), and the segmentation of the respective heart beats into segments for allowing better feature extraction.

Abstract: A method and system for electronically classifying a pre-processed heart sound signal of a patient as functional (normal) or pathological is provided. The pre-processed patient heart sound signal is segmentised and features are extracted therefrom (104) to build up a feature vector which is representative of the heart sound signal. The feature vector is then fed to a diagnostic decision support network (105) comprising a plurality of artificial neural networks, each relating to a known heart pathology, which is in turn used to conduct the classification.

Abstract: A method and device for heart murmur extraction and classification is disclosed. Data corresponding to a heart sound/signal is acquired from a patient through a data acquirer. The heart sound data is processed to isolate systole and diastole periods. Features to discriminate between the defects types associated with different heart murmurs are extracted, and the heart murmurs are detected and identified based on the extracted features using a fuzzy controller.

Abstract: A system for detection of frequency power for diagnosing coronary artery disease (CAD), comprising: an acoustic sensor to be placed on the chest of a patient to generate acoustic signals SA: a memory adapted to store acoustic signals SA; a control unit adapted to receive said acoustic signals SA; the control unit comprising: an identification unit to identify diastolic or systolic periods in a predetermined time period and to generate a period signal SP, a filtering unit adapted to apply a filter to said identified periods to generate a low frequency band signal SLFB indicating low frequency bands of identified periods; a calculation unit to estimate the power in said low frequency band of identified periods, to calculate a low frequency power measure and to generate a low frequency power measure signal SLFP. The invention also relates to a stethoscope and a method for detection of low frequency power.

Abstract: Systems and methods for acoustic detection of coronary artery disease (CAD) and automated editing of heart sound data are provided.

Abstract: An image forming system includes a substrate transport unit, an image forming module, an event sensing module, a heartbeat generation module, a signal detection module, and a repositioning module. The substrate transport unit may transport substrate including at least one splice along a transport path. The image forming module may form an image on the substrate. The event sensing module may detect an event and provide an event signal along a signal path in response to the event. The heartbeat generation module may provide a heartbeat signal different than the event signal along the signal path. The signal detection module may determine a presence of the event signal and an absence of the heartbeat signal. The repositioning module may move the image forming module from a first position to a second position in response to a determination of the presence of the event signal.

Abstract: A catheter system can include a first catheter having an elongated body that defines a lumen, and a second catheter slidably disposed within the lumen of the first catheter. The second catheter can include an acoustic device. The acoustic device can create a sound for verifying the location of the second catheter within a body lumen. The distal end portion of the second catheter can include a pre-formed bend that extends at a non-zero angle relative to a longitudinal axis of the first catheter. In some embodiments, the second catheter can be used to aspirate a substance from a body lumen.

Abstract: Each spectral slice array of a plurality is generated for each time segment of a plurality of time segments of a cardiovascular sound signal is convolved with a local spectral averaging window to generate a local spectral average array that is searched for bruit candidates responsive to associated time power or energy values, power levels, and skew values, so as to provide an indication of cardiovascular disease, that may also be responsive to skew-responsive and power-level-responsive probability terms and to a composite thereof. A probability indicator of cardiovascular disease is responsive to a second product of second terms, each second term responsive to a first product of first terms, each first term representative of a probability of no bruits for all time segments for each frequency segment of a two dimensional bruit candidate probability array, each second term representative of a probability of no repetitive bruits within each frequency segment.

Abstract: Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively.

Abstract: Disclosed techniques include monitoring a physiological characteristic of a patient with a sensor that is mounted to an inner wall of a thoracic cavity of the patient, and sending a signal based on the monitored physiological characteristic from the sensor to a remote device.

Abstract: A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.

Abstract: Devices and methods for detecting heart failure (HF) events or identifying patient at elevated risk of developing future HF events are described. A medical device can detect contextual condition associated with a patient, such as an environmental context or a physiologic context, sense a heart sound signal, and perform multiple measurements of heart sound features in response to the detected patient contextual condition meeting specified criterion. The contextual condition includes information correlating to or indicative of a change in metabolic demand of a patient. The medical device can use the physiologic signals to calculate one or more signal metrics indicative of diastolic function of the heart such as a trend of the heart sound features. The medical device can use the signal metrics to detect an HF event or to predict the likelihood of the patient later developing an HF event.

Abstract: A wireless stethoscope is described, having wireless sensors that are enclosed in disposable pads so that the same pads are not used on more than one patient, preventing cross-infection of patients associated with conventional stethoscopes. The present wireless stethoscope also detects pulmonary sounds and cardiac sounds, allowing the user to monitor one or the other without interference. Also described is a method for diagnosing a pulmonary condition using the wireless stethoscope.

Abstract: A cardiac-based metric is computed based upon characteristics of a subject's cardiac function. In accordance with one or more embodiments, the end of a mechanical systole is identified for each of a plurality of cardiac cycles of a subject, based upon an acoustical vibration associated with closure of an aortic valve during the cardiac cycle. The end of an electrical systole of an electrocardiogram (ECG) signal for each cardiac cycle is also identified. A cardiac-based metric is computed, based upon a time difference between the end of the electrical systole and the end of the mechanical systole, for the respective cardiac cycles.

Abstract: This disclosure relates to devices, systems, and methods for validating locational data for a monitoring device. The external monitoring device located on a patient may include one or more processors, one or more memory devices, one or more power devices, one or more heart rate detection devices, and one or more heart sound detection devices. Further, the method may include determining a plurality of status of an external monitoring device located on a patient via one or more processors based on obtained heart rate data and obtained heart sound data. The external monitoring device state may be generated via a validation module based on the heart rate data and the heart sound data.

Abstract: A method and system for electronically classifying a pre-processed heart sound signal of a patient as functional (normal) or pathological is provided. The pre-processed patient heart sound signal is segmentised and features are extracted therefrom (104) to build up a feature vector which is representative of the heart sound signal. The feature vector is then fed to a diagnostic decision support network (105) comprising a plurality of artificial neural networks, each relating to a known heart pathology, which is in turn used to conduct the classification.

Abstract: A method and device for detecting a cardiac event that includes sensing cardiac electrical signals representative of electrical activity of a heart of a patient, detecting the cardiac event in response to the sensed cardiac signals, determining an indication of signal reliability corresponding to the sensed cardiac signals as being one of a reliable signal and a not reliable signal, and switching operation of the device between a first mode of determining whether the sensed signal is one of treatable and not treatable and a second mode of determining whether the sensed signal is one of treatable and not treatable in response to the determined indication of signal reliability.

Abstract: A vital signs sensing apparatus includes a sound sensing unit and a pressure unit. The sound sensing unit senses a sound inside a body of a user and produces an audio signal. The pressure unit produced a pressure signal. The pressure signal indicates a degree of closeness between the vital signs sensing apparatus and the user. The audio signal is transformed into a processed audio signal according to the pressure signal.

Abstract: A medical image diagnostic apparatus provided with an image acquisition unit configured to acquire in-vivo information about an object to be examined as a medical image, a display unit configured to display the medical image, a setting unit configured to set a target region of volume measurement in the medial image displayed on the display unit, a calculation unit configured to perform calculation to split the target region into a plurality of volume elements, calculate the moving distance of the vertices of the volume elements when the target region of the acquired medical image moves, calculate the volumes of the volume elements after the movement using the calculated moving distance of the vertices, totalizing the calculated volumes of the volume elements after the movement and using the total volume as the volume of the target region, and a control unit configured to display the volume of the target region on the display unit.

Abstract: Methods and apparatuses are described to obtain cardiac data, which includes acquiring vibrational field cardiac data from a transducer wherein the transducer measures vibration over a surface of a human's body. An unwanted coronary event is separated from vibrational cardiac data. A transient event is extracted from the vibrational cardiac heart cycle data. The transient event occurs during a diastolic interval within a heart cycle. The transient event is evaluated for a condition of coronary artery blood flow turbulence and a condition of health of a coronary artery is assessed from a feature in the vibrational frequency power spectrum estimate.