Qualitative Or Quantitative Analysis Of Breath Component Patents (Class 600/532)
  • Patent number: 10342456
    Abstract: An apparatus and method is provided for analyzing a breathing gas flowing along a breathing tubing for subject breathing. The breathing gas comprises breathing cycles having different phases. Liquid particles can be delivered intermittently depending on the phase, or continuously into the breathing gas. The apparatus comprises a gas sample supplier for adjusting gas sample supply from the breathing gas, and a gas analyzer for receiving the gas sample adjusted by the gas sample supplier and for measuring the gas sample property. The apparatus further comprises a processing unit for receiving a signal indicative of one of the phases of the breathing cycle and the delivery timing of the liquid particles. The processing unit is able to control the sample supplier based on the signal to limit access of liquid particles with the gas sample towards the gas analyzer.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: July 9, 2019
    Assignee: General Electric Company
    Inventor: Heikki Antti Mikael Haveri
  • Patent number: 10285642
    Abstract: A wearable breath analysis device is disclosed that may be worn, for example, around the neck or wrist of a user. The wearable device may be a stand-along device (in which case it may include a display that provides a user interface), or may operate in conjunction with a smartphone or other command device. The wearable device may include auditory and/or vibratory notice and communications features or capabilities, for example, such as a reminder or notice to conduct a breath analyte measurement, instructions to the user in the course of conducting the measurement, and notice of the breath analyte measurement results. The auditory or vibratory notice may be provided at the wearable, and/or at the command device where a command device is used. Related methods also are provided.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: May 14, 2019
    Assignee: Invoy Holdings, LLC
    Inventors: Lubna Ahmad, Salman Ahmad, Zachary Smith
  • Patent number: 10258276
    Abstract: Methods of coaching a user of a breathalyzer to make use of correct blowing technique when blowing into the breathalyzer are provided. Methods of setting up a breathalyzer such that it adjusts a breathalyzer's parameters to account for jurisdictional variations in blood and/or breath alcohol limits and other standards are also provided.
    Type: Grant
    Filed: October 18, 2016
    Date of Patent: April 16, 2019
    Assignee: Now Group UK Ltd
    Inventor: Hunter David Abbott
  • Patent number: 10251581
    Abstract: Devices and methods for measuring and quantifying airflow through the adult human nose by detecting and measuring the amount of moisture condensate in contact with a pair of flat surfaces or substrates positioned beneath the patient's nose for a predetermined length of time, usually about three (3) seconds. The device comprises a microprocessor, a memory, an output device and a moisture sensing unit. The moisture sensing unit, comprising twin left and right detectors, produces output signals representative of the amounts of moisture condensate in contact with the left and right detectors, respectively. The microprocessor determines the volume density, current density, or relative humidity density from a series of measurements of the condensation as it propagates and decays during exhalation. The microprocessor stores the results in the memory and transmits the data, as well as calculated nasal condition information, to the output device, preferably a digital display.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: April 9, 2019
    Inventor: Randolph B. Capone
  • Patent number: 10244198
    Abstract: A system for testing an individual for illicit or other substances is described. The system operates in tandem with a mobile device (smartphone) application, which employs a camera of the mobile device to capture and record the self-administered specimen collection process for verification and rule compliance. The system guides the user through the process via on-screen prompts on the mobile device, and includes tracking of the collected specimen from the moment of collection until it is sealed in a tamper-proof container to be mailed for external testing at a lab. A breathalyzer may also be used with the system to test for the presence of alcohol in the user's body, the use of which is also monitored and recorded via the on-board camera of the mobile device for verification.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: March 26, 2019
    Inventor: James Kirk Cizerle
  • Patent number: 10188295
    Abstract: Methods and systems for an integrated sensor network are described. In one embodiment, sensor data may be accessed from a plurality of motion sensors and a bed sensor deployed in a living unit for a first time period. An activity pattern for the first time period may be identified based on at least a portion of sensor data associated with the first time period. The activity pattern may represent a physical and cognitive health condition of a person residing in the living unit. Additional sensor data may be accessed from the motion sensors and the bed sensor deployed for a second time period. A determination of whether a deviation of the activity pattern of the first time period has occurred for the second time period may be performed. An alert may be generated based on a determination that the derivation has occurred. In some embodiments, user feedback is captured on the significance of the alerts, and the alert method is customized based on this feedback. Additional methods and systems are disclosed.
    Type: Grant
    Filed: June 1, 2010
    Date of Patent: January 29, 2019
    Assignee: The Curators of the University of Missouri
    Inventors: Marjorie Skubic, Marilyn J. Rantz, Mihail Popescu, Shuang Wang, Isaac J. Sledge, Rainer Dane A. Guevara, Elena Florea, James M. Keller
  • Patent number: 10178963
    Abstract: A gas collection apparatus for use by a user includes a housing with an inlet and an outlet to permit a breath sample to flow therethrough. The housing includes a first compartment and a second compartment, a chemo-resistive analysis assembly having a substrate coupled to a sensor array and disposed within the first compartment, the substrate being operably connected to a voltage control unit coupled to the housing to heat the sensor array to a desired temperature, a resistance control unit coupled to the housing to measure resistance in the sensor array, an optical analysis assembly having a light-emitting diode array and a photodiode array coupled to the second compartment, and a processor coupled to the housing and operably connected to the chemo-resistive analysis and optical analysis assemblies.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: January 15, 2019
    Assignee: DYNOSENSE, CORP.
    Inventors: Saeed Azimi, Elaheh Farjami
  • Patent number: 10175247
    Abstract: The invention provides a physical change evaluation device, method, and program capable of easily evaluating physical change from the past to the present, and from the present into the future. A physical change evaluation device 10 acquires a ketone concentration measurement measuring ketone excreted from a user, acquires physical data relating to the body of the user, evaluates physical change in the user based on the acquired ketone concentration measurement and the physical data, and outputs an evaluation result.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: January 8, 2019
    Assignee: Tanita Corporation
    Inventors: Miyuki Kodama, Ayumi Sano, Yasuhiro Kasahara, Naotaka Minagawa, Moe Watabe
  • Patent number: 10168315
    Abstract: A sensor technology comprising a single nano-material (gold nanoparticles and/or carbon nanotube) based sensor or a plurality of sensors in conjunction with a pattern recognition algorithm for non-invasive and accurate diagnosis of tuberculosis caused by M. tuberculosis bacteria in a subject. The sensor technology is suitable for population screening of tuberculosis, particularly in resource-poor and developing countries.
    Type: Grant
    Filed: October 27, 2013
    Date of Patent: January 1, 2019
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Hossam Haick, Morad Nakhleh
  • Patent number: 10159459
    Abstract: A sound localization system includes a multi-mic sound collector and a computing device. The multi-mic sound collector includes a carrier and a plurality of sound receivers removably attached to the sound receivers. The computing device includes a data communicator, a synchronizer, and a processor. The data communicator receives preprocessed audio data from the multi-mic sound collector. The synchronizer synchronizes the preprocessed audio data. The processor analyzes the synchronized audio data to identify and localize a target audio feature. A sound localization method of the sound localization system is also provided. The present invention facilitates monitoring of the functioning or physiological signs of a monitored subject and allows early detection and diagnosis of abnormalities or diseases.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: December 25, 2018
    Assignee: iMEDI PLUS Inc.
    Inventors: Kun-Hsi Tsai, Sheng-Hsiang Kung, Shih-Cheng Lan, Yun-Fan Chang
  • Patent number: 10149953
    Abstract: This invention relates to a breath indicator that is receivable by a part of a breathing assistance apparatus that supplies gas to a patient. The indicator comprises an elongate body having a gas sampling end and an attachment end. The attachment end is adapted to attach to a part of a breathing assistance apparatus and for locating the gas sampling end. The gas sampling end is to be located in a region where gas from the patient is to be exhaled. The gas sampling end being in communication with a sensor comprising a detector material changeable between a first visual indicator state relating to an inhalation phase of the patient, and a second visual indicator state relating to an exhalation phase of the patient. The detector material is capable of changing between the visual indicator states at a sufficient rate to substantially correspond with the inhalation and exhalation phases of the patient.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: December 11, 2018
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Jonathan Mark Church, Simon Boulton, David Robert Kemps
  • Patent number: 10143418
    Abstract: The system of the present invention is intended to provide a simple, out-of-clinic sleep disorders testing tool. It can be used for pretest screening and diagnosis, and post therapy follow-up of patients. The hardware component comprises a disposable sensor pack containing a PVDF airflow sensor and a PVDF pulse wave sensor, each of which is permanently connected to a signal conditioning and communications module configured to communicate with a patient's smartphone via a Bluetooth circuit. An APP stored in the smartphone allows a patient to initiate a diagnostic recording, collect and store digitized data onto the phone and, subsequently, upload data to a secure server for analysis on a host computer following completion of the test.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: December 4, 2018
    Assignee: Dymedix Corporation
    Inventors: James P. Moore, Todd M. Eiken
  • Patent number: 10143425
    Abstract: In one embodiment of the invention, an interactive vital signs scanning method is disclosed including concurrently scanning for a plurality of vital signs with a portable vital signs scanner; detecting movement of the portable vital signs scanner during the scanning for the plurality of vital signs; and determining a measure of quality of the scanning for the plurality of vital signs with the portable vital signs scanner. In another embodiment, a method of improving the quality of vital signs data is disclosed including concurrently sensing data from a plurality of vital signs sensors over a period of time with a portable vital signs scanner; determining a plurality of vital sign values for a respective plurality of vital signs in response to the sensed data from the plurality of vital signs sensors over the period of time; and fusing at least two vital sign values of the plurality of vital sign values for the respective plurality of vital signs.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: December 4, 2018
    Assignee: Scanadu Incorporated
    Inventors: Wenyi Zhao, Brandon Dennis Woolsey, Walter De Brouwer, Eron Anthony Villarreal, Whitney Morgan McGowan, Martin Zizi
  • Patent number: 10139392
    Abstract: A method and an apparatus for breath analysis, the method comprising determining an isotopic composition profile, or a concentration profile of a species, of a first breath cycle; determining a threshold; determining a sampling time; and measuring the isotopic composition, or concentration of the species, during a second breath cycle at the sampling time triggered by reaching the threshold.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: November 27, 2018
    Assignee: TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
    Inventors: Teemu Kääriäinen, Albert Manninen
  • Patent number: 10136839
    Abstract: An airway adaptor includes: an airway case; and an expired gas guiding portion which is connected to the airway case to introduce a respiratory gas to the airway case. The airway case includes: a first respiratory gas flow path in which the respiratory gas flows in a first direction; and a second respiratory gas flow path in which the respiratory gas flows in a second direction opposite to the first direction.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: November 27, 2018
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Shinji Yamamori
  • Patent number: 10111606
    Abstract: An integrated condenser is described. This integrated condenser includes an outer surface region on a sampler surface that facilitates condensing at least a component in a received gas-phase sample into liquid-phase droplets on the sampler surface, and aggregating and moving the condensed droplets radially toward an inner surface region on the sampler surface that receives the condensed droplets. For example, the outer surface region may include a set of micro-patterned concentric rings, each of which includes a set of radially oriented wall-groove pairs. Moreover, the sampler surface may be increasingly less hydrophobic along a radial direction toward the center of the sampler surface, thereby creating an axisymmetric wettability gradient.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: October 30, 2018
    Assignee: The Regents of the University of California
    Inventors: Cristina Davis, Hamzeh Bardaweel, Konstantin Zamuruyev, Jean-Pierre Delplanque, Nicholas J. Kenyon
  • Patent number: 10111588
    Abstract: A transceiver for interfacing with an analyte sensor. The transceiver may include an interface device and a notification device. The interface device may be configured to convey a power signal to the analyte sensor and to receive data signals from the analyte sensor. The notification device may be configured to generate one or more of a vibrational, aural, and visual signal based on one or more data signals received from the analyte sensor. The interface device of the transceiver may receive analyte data from the analyte sensor, and the transceiver may comprise a processor configured to calculate an analyte concentration value based on the received analyte data. The notification device may be configured to generate one or more of aural, visual, or vibrational alarm when the calculated analyte concentration value exceeds or falls below a threshold value.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: October 30, 2018
    Assignee: Senseonics, Incorporated
    Inventors: Szymon Tankiewicz, Jeremy Emken, Andrew DeHennis, Todd Whitehurst
  • Patent number: 10092221
    Abstract: A method of analyzing breathing data representing a shape of the trunk of a subject 104 as a function of time to monitor and/or analyze the subject's breathing pattern. The data is measured and processed into a data array relating to a 2-dimensional grid having grid points, a position in space of the shape at each grid point and points of time. The method includes the steps of mapping the data array onto a 2-dimensional array, decomposing the 2-dimensional array and forming a signature of the subject 104 from the decomposed 2-dimensional array representing a motion pattern.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: October 9, 2018
    Assignee: PNEUMACARE LIMITED
    Inventors: Joan Lasenby, Willem Hessel De Boer
  • Patent number: 10034621
    Abstract: Apparatuses are described to accurately determine a gas concentration of a sample of a patient's breath. The apparatuses may include a sample compartment, a breath speed analyzer, a gas analyzer, and a processor. The sample compartment includes an inlet that receives the breath. The breath speed analyzer determines the speed of a portion of the breath. The gas analyzer determines a gas concentration. The processor includes an algorithm that determines a degree of non-homogeneity of the sample based on the speed, and a corrected gas concentration based on the degree of non-homogeneity. In some variations, the gas correction is determined independently of patient cooperation. Apparatuses may be tuned based on the intended population's expected breathing pattern ranges such that the sample compartment is filled with a homogenous end-tidal gas sample regardless of an individual's breathing pattern. These apparatuses are useful, for example, for end-tidal CO analysis. Methods are also described.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: July 31, 2018
    Assignee: Capnia, Inc.
    Inventors: Anthony D. Wondka, Anish Bhatnagar
  • Patent number: 10031126
    Abstract: A system for monitoring an exhaled breath of a subject is described. A breath collector can be configured to receive exhaled breath from a subject. One or more sensors can be configured to output a concentration of a first gas compound in the received exhaled breath, and to output a concentration of a second gas compound in the received exhaled breath. The second gas compound is used to normalize the concentration of the first gas based on different physiological states of the subject. A processor operably coupled to the one or more sensors is configured to calculate a ratio of the first gas compound to the second gas compound based on the determined concentrations, and to determine a normalized concentration of the first gas compound. This ratio may be monitored to evaluate an inflammatory state of the subject.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: July 24, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Donald R. Blake, Alan G. Barbour
  • Patent number: 9986935
    Abstract: A compact, on-airway, respiratory gas analyzer for performing pulmonary function tests incorporates an IR spectroscopy light guide having a curved, rather than linear, sample chamber that lies transverse to a direction of respiratory gas flow. Cooperating with the sample chamber is an impact plate that functions to steer respiratory and test gases impinging on the impact plate into the curved sample chamber. A source of IR energy is at one end of the sample chamber and an electro-optical sensor responsive to IR energy is disposed at an opposite end of the chamber. The respiratory gas analyzer also includes gas flow paths and valving for carrying out lung capacity and lung diffusion tests.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: June 5, 2018
    Assignee: MGC Diagnostics Corporation
    Inventors: David A. Blanton, Charles P. Howard, Joshua L. Stevenson
  • Patent number: 9943248
    Abstract: According to one of aspects, an electronic device used for a phone call includes: a sound input unit to which a sound is input during a phone call; and a sensor that is provided near the sound input unit and detects a substance contained in a gas.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: April 17, 2018
    Assignee: KYOCERA CORPORATION
    Inventor: Hideki Hidaka
  • Patent number: 9936897
    Abstract: An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: April 10, 2018
    Assignee: Capnia, Inc.
    Inventors: Lee R. Carlson, Edward A. McClatchie, Joe Martinosky, Ralph Walden, Elvir Causevic
  • Patent number: 9919123
    Abstract: The flow rate of a gaseous sample of exhaled breath through an analytical device is controlled by a pump, and in certain embodiments two pumps. Placement of the analyte sensor in a secondary stream branching off of the primary stream through the device offers further control over the manner, duration, and quantity of the breath that is placed in contact with the sensor.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: March 20, 2018
    Assignee: Circassia AB
    Inventors: Kevin Nason, Jonathan Fay, Bryan P. Flaherty, Bhairavi R. Parikh
  • Patent number: 9901482
    Abstract: A method for manufacturing a protrusion splint comprising an upper support area configured to provide a defined abutment of a maxilla area, and a lower support area configured to provide a defined abutment of a mandible area. The method includes fixing the maxilla area and the mandible area in a first position so that the mandible area is shifted forward relative to the mandible area. A three-dimensional image data set of an air passage in a region of a trachea is created in the first position. The air passage is checked whether an opening value of the air passage corresponds to a target value. A second position of the maxilla area and of the mandible area to each other is defined depending on the checking. The protrusion splint is manufactured so that the mandible area is held relative to the maxilla area in the second position.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 27, 2018
    Assignee: HICAT GMBH
    Inventor: Daniel Gruenberg
  • Patent number: 9901384
    Abstract: A medical device may include a stimulation member configured to apply a stimulus to a nerve that is configured to control a contraction of an airway distal to the nerve, and a measurement member configured to measure an effect of the stimulus on the airway. The medical device also may include an energy delivery element configured to deliver energy to tissue defining the airway to reduce an effect of the stimulus on the airway. The energy delivery element may be disposed at or distally of the stimulation member.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: February 27, 2018
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Bryan Allen Clark, Aiden Flanagan, Michael Eppihimer, William Conrad Stoffregen, Juan Gabriel Hincapie Ordonez
  • Patent number: 9888870
    Abstract: The disclosure is directed to intrapleural air leak detection and monitoring. According to various embodiments of the disclosure, an air leak may be detected utilizing at least one sensor to determine whether fluid extracted from a pleural cavity of a patient includes carbon dioxide and/or a second substance. The second substance may be a foreign substance inhaled by the patient to confirm presence of the air leak. The air leak may be further monitored over a period of time by collecting temporally successive measurements associated with detected concentrations of carbon dioxide. Therefore, tissue damage and recovery may be assessed according to objectively collected criteria.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: February 13, 2018
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Dimitrios Miserlis, Kim Cluff, Abby M. Kelly, Suzanne J. Higgins, Max H. Twedt
  • Patent number: 9885693
    Abstract: A measuring system and device (12), a reaction carrier (14) and a measuring method for measuring a concentration of gaseous and/or aerosol components of a gas mixture are provided. The reaction carrier includes flow channels (42) and a coding that is detectable by a position sensor (36) to position the reaction carrier flow channels. At least one flow channel defines a reaction chamber (46) in which optically detectable reaction material (48) is provided. A position sensor detects a relative position of the reaction carrier. A conveying device (28) moves the reaction carrier relative to gas connections (22, 24) of a gas-inlet channel (16) and a gas-outlet channel (16, 18) between a measuring position with gas connections via a first flow channel for flushing the gas inlet channel and gas connections via a second flow channel defining a reaction chamber, for measuring the component of the gas mixture.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: February 6, 2018
    Assignee: Dräger Safety AG & Co. KGaA
    Inventors: Hans-Ullrich Hansmann, Philipp Rostalski
  • Patent number: 9861298
    Abstract: A gas sampling line having a channel for conducting respiratory gases from a patient respiratory interface to a gas monitor, the gas sampling line comprising, i.a., a gas sampling tube comprised of a polyether block amide material, the polyether segments of which comprise polyethyleneoxide. Use of a tube comprised of a polyether block amide material, the polyether segments of which comprise polyethyleneoxide, for sampling of respiratory gases; and a method for sampling of respiratory gases, the method comprising conducting respiratory gases through such a tube. A gas analysis system for analyzing respiratory gases, comprising a gas sampling line as defined above and a gas monitor connectable to the gas sampling line.
    Type: Grant
    Filed: September 11, 2009
    Date of Patent: January 9, 2018
    Assignee: Masimo Corporation
    Inventors: Anders Eckerbom, Robert Zyzanski
  • Patent number: 9795324
    Abstract: A computer-implemented method, and related system, for monitoring the wellbeing of an individual by providing eyewear that includes at least one sensor for monitoring the motion of the user. In various embodiments, the system receives data generated by the at least one sensor, uses the data to determine the user's movements using the received data, and compares the user's movements to previously established movement patterns of the user. If the system detects one or more inconsistencies between the user's current movements as compared to the previously established movement patterns of the user, the system may notify the user or a third party of the detected one or more inconsistencies. The system may similarly monitor a user's compliance with a medical regime and notify the user or a third party of the user's compliance with the regime.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: October 24, 2017
    Assignee: Vision Service Plan
    Inventors: Jay William Sales, Richard Chester Klosinski, Jr., Matthew Allen Workman, Meghan Kathleen Murphy, Matthew David Steen
  • Patent number: 9791366
    Abstract: A gas detector (10) includes a cell internal space (130) into which a target gas is supplied, the target gas exhibiting an absorption peak in an absorption spectrum; a light source (410) configured to generate light having at least a wavelength belonging to the absorption peak; and a photodetector (420) configured to detect the light that has emitted from the light source (410) and has propagated through the cell internal space (130). The gas detector (10) further includes a conductive thin film (220) in which a plurality of optical apertures (222) are regularly arranged such that a transmission peak in a transmission spectrum is superimposed over the absorption peak in the absorption spectrum along a wavelength axis. The conductive thin film (220) is provided on an optical path extending from the light source (410) to the photodetector (420), and is provided so as to be contactable with the target gas within the cell internal space (130).
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: October 17, 2017
    Assignee: NATIONAL UNIVERSITY CORPORATION YOKOHAM NATIONAL UNIVERSITY
    Inventors: Yoshiaki Nishijima, Yuta Adachi
  • Patent number: 9770192
    Abstract: A method of avoiding a contaminant which would skew an analyte result in a breath analysis method and of calibrating subject of the breath analysis includes, immediately before the breath analysis method or the collection of breath for the breath analysis method, administering to the subject a predetermined gas composition. A system for analyzing an analyte in breath of a subject while avoiding a local contaminant which would skew an analyte result and calibrating the subject of so that the result of the analyte analysis will be the same regardless of where the test is performed geographically, includes a source of a predetermined gas composition immediately before the breath analysis method or the collection of gas for the breath analysis method, administering to the subject a predetermined gas mixture.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: September 26, 2017
    Inventors: Richard C. Fuisz, Joseph M. Fuisz
  • Patent number: 9687176
    Abstract: This disclosure concerns improved capabilities for evaluating pulmonary arterial hypertension (PAH). A system and method of evaluating PAH in a subject may include measuring end tidal partial pressure of exhaled carbon dioxide in the subject, wherein the measurement is made orally using described systems or devices. Integrated sensors enable the measurement and characterization of other respiratory gas components, some of which may be indicative of disease. The system and method can be used to monitor a course of treatment for PAH.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: June 27, 2017
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Anna R. Hemnes, Alexander Newman, John Newman
  • Patent number: 9671389
    Abstract: There is provided an apparatus for measuring levels of a specified gas in exhaled breath, the apparatus comprising a photoacoustic sensor for providing a measurement representative of the level of the specified gas in the exhaled air, wherein the photoacoustic sensor comprises a light source that is modulated at a first frequency; a sound speed measurement module for measuring the sound speed of the exhaled breath, wherein the sound speed measurement module operates either at a second frequency that is substantially different to the first frequency or in a pulsed mode; wherein the first frequency of the modulated light source is adjusted during exhalation in accordance with the measured speed of sound of the exhaled breath.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: June 6, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Hans Willem Van Kesteren
  • Patent number: 9657326
    Abstract: The present invention relates to a method of diagnosing an existing or developing acute pneumonia induced by a microorganism by detecting one or more volatile organic compound(s) in a subject's sample and the use of one or more volatile organic compound(s) for the detection of Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae or Haemophilus influenza and optionally opportunistic pathogen Candida albicans.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: May 23, 2017
    Assignee: MEON Medical Solutions GmbH & Co. KG
    Inventors: Horst Ruether, Anton Amann
  • Patent number: 9659149
    Abstract: The invention relates to a medical monitoring system (100) based on sound analysis in a medical environment. A sound level analyzer (SLA, 10) is capable of providing an indicator for perceived levels of sound from a number of sound events, and a data storage modality (DSM, 20) is receiving and storing said indicator for perceived levels of sound and also corresponding information from an associated patient monitoring system (PMS, 60) handling information indicative of a physical and/or mental condition of a patient under influence by sound. A sound event analyzer (SEA, 30) is further being arranged for performing, within a defined time window, an overall sound analysis (ANA, 50) related to physical and/or mental condition of the patient that may be influenced by sound in order to assist or supervise medical personal with respect to the acoustic environment.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: May 23, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Armin Gerhard Kohlrausch, Thomas Falck, Albertus Cornelis Den Brinker
  • Patent number: 9581585
    Abstract: A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement. The receiver is configured to receive a breath sample from a user. The first plurality of layers and second plurality of layers being configured to interact in response to the level of acetone in the breath sample. The breath acetone meter further including a light source arranged to emit a light onto the receiver. A sensor is arranged to receive the light and output a voltage in response to receiving the light, wherein the voltage is proportional to an amount of acetone in the breath sample.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: February 28, 2017
    Assignee: WESTERN NEW ENGLAND UNIVERSITY
    Inventors: Ronny Priefer, Michael J. Rust
  • Patent number: 9572518
    Abstract: Based on a capnometry signal, one or more breathing parameters of a subject are determined that require valid breaths by the subject to be distinguished from anatomical events that cause the CO2 content of gas at or near the airway of the subject to fluctuate. To improve the accuracy of one or more of these determinations, gas at or near the airway of the subject is diluted.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: February 21, 2017
    Assignee: Koninklijke Philips N.V.
    Inventor: Joseph Allen Orr
  • Patent number: 9498150
    Abstract: There is provided a breath sampling tube comprising a deflector adapted to reduce liquid intake into a sampling inlet. There is also provided a breath sampling tube including a deflector adapted to deflect liquid droplets present in breath to reduce liquid at the sampling inlet. There is also provided a breath sampling system including a gas analyzer and a breath sampling tube comprising a deflector adapted to deflect breath to reduce liquid at the sampling inlet. There is also provided a breath sampling system including a gas analyzer and a breath sampling tube comprising a deflector adapted to deflect liquid droplets present in breath to reduce liquid at the sampling inlet.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: November 22, 2016
    Assignee: Oridion Medical 1987 Ltd.
    Inventors: Joshua Lewis Colman, Gershon Levitsky
  • Patent number: 9486169
    Abstract: A portable ketone measurement device measures ketone levels in breath samples or other bodily fluid samples of a user, and communicates the ketone measurements to an application that runs on a smartphone or other mobile device of the user. The application may communicate with, and report the measurements to, a remote server. One or more components of the system (e.g., the portable ketone measurement device, the mobile application, and/or the server) may, where appropriate, adjust the ketone measurements to compensate for ketone variations resulting from, e.g., the age of the user, a medical condition of the user, a missed medication event, or an interrupted sleep event. The application may, in some scenarios, withhold the display of a ketone measurement from the user until an authorization has been received from the server.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: November 8, 2016
    Assignee: Invoy Technologies, LLC
    Inventor: Lubna M. Ahmad
  • Patent number: 9474484
    Abstract: A physiological monitor device includes a central processing unit (CPU) that is configured to control operation of the device, a display screen, and one or more computer readable data storage media storing software instructions that, when executed by the CPU, cause the device to: create or modify a patient profile, select a patient test, store one or more test parameters selected or entered for the patient test, store one or more thresholds selected or entered for at least one of the test parameters, store one or more instructions for the patient, start the test, display test results while the test is in progress, determine whether any of the test parameters exceed limits set by the one or more thresholds, take one or more actions when it is determined that one or more of the test parameters exceed the limits set by the one or more thresholds, provide a summary and analysis of the test results, and send the test results to a computing device.
    Type: Grant
    Filed: May 27, 2014
    Date of Patent: October 25, 2016
    Assignee: WELCH ALLYN, INC.
    Inventors: Matthew J. Kinsley, Matthew D. Mullin, John A. Lane, Cynthia A. Kuiper, Daniel J. Wilson, Shawn C. St. Pierre
  • Patent number: 9445748
    Abstract: A device for fractionally collecting contents of exhaled air by changing the state of matter of the contents by means of the Joule-Thomson effect arising during the expansion of pressurized gas. The temperature of the exhaled air conducted in a flow channel is lowered, because of the cooling of the expanding gas, to a temperature that is suitable for condensing the contents in the exhaled air flow. This device and method provides a more efficient means by which condensate can be separated from exhaled air in comparison to conveying exhaled air along a cooling surface for the condensation of the contents, as a result of which condensation of the contents occurs only in the area of these cooling surfaces, so that several breath cycles are required for the collection of sufficient condensate for analysis.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: September 20, 2016
    Assignee: MTI Medtech Innovation GmbH
    Inventor: Ruediger Eichler
  • Patent number: 9441260
    Abstract: A biological material such as platelets is sealed inside a container with a dead space to accommodate a metabolic gas. The concentration of the gas in the dead space is monitored while the container remains sealed. In some embodiments, the container is permeable to the gas. In other embodiments, the biological material is the only growth medium in the container. The disposal of the biological material is in accordance with the monitored gas concentration. Preferably, the gas concentration is measured spectroscopically. A container for a biological material includes a main body that retains the biological material but that is permeable to a gas and a reservoir in fluid communication with the main body that is transparent to an optical wavelength that is absorbed by the gas.
    Type: Grant
    Filed: November 11, 2012
    Date of Patent: September 13, 2016
    Assignee: VAYU SENSE AG
    Inventors: Noel Axelrod, David Nuttman, Moria Shimoni
  • Patent number: 9429564
    Abstract: A method recovering one or more nonvolatile compounds from an exhaled aerosol collected on an electrostatic filter membrane (205) comprises eluting the nonvolatile compounds from the filter with a polar solvent and collecting the eluate. The method is useful for processing samples collected from a portable breath analysis device comprising a sampling filter membrane for analysis.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: August 30, 2016
    Assignee: Sensa Bues AB
    Inventor: Olof Beck
  • Patent number: 9417222
    Abstract: A gas analyzer includes: a gas measuring portion which performs a measurement on a gas; a case which houses the gas measuring portion; a liquid separator which includes a reservoir for storing a liquid component separated from the gas; a holder portion which holds the liquid separator; and a rotation mechanism which mounts the holder portion to the case.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: August 16, 2016
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Isao Matsubara, Yutaka Uchiyama
  • Patent number: 9408556
    Abstract: The present embodiments disclose a device including a module for sampling, separating and enriching a detected object, an exhaled breath condensates (EBCs) detection module and a combined volatile organic compounds (VOCs) detection module. The sampling module is connected with the EBCs detection module via a syringe pump for sample injection and is connected with the combined VOCs detection module by a capillary separation column. EBCs and VOCs in human exhaled breath are simultaneously sampled, separated and condensed; the heavy metal ions, cell factors, etc. in the collected EBCs are detected with a light addressable potentiometric sensor (LAPS); the condensed VOCs can be quantitatively detected by the combined VOCs detection module with a high sensitivity; and a heating rod and a platinum resistor can be conveniently replaced because a separated outlet heating piece is designed in the combined VOCs detection module.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: August 9, 2016
    Assignee: ZHEJIANG UNIVERSITY
    Inventors: Ping Wang, Di Wang, Le Wang, Jin Yu, Kai Yu, Yishan Wang, Lin Wang, Cong Zhao
  • Patent number: 9404836
    Abstract: Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meta-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi-endpoint detection assay formats.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: August 2, 2016
    Assignee: Pulse Health LLC
    Inventors: Gerald Thomas, Brian Young, Juven Lara, Charles Noll, James Ingle
  • Patent number: 9374629
    Abstract: Methods, apparatus, systems and articles of manufacture are disclosed herein to classify audio. An example method includes determining a first count of volume events having a first period of time associated with the audio. The example method also includes determining a second count of volume events having a second period of time associated with the audio. The example method also includes classifying the audio based on the first count and the second count.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 21, 2016
    Assignee: The Nielsen Company (US), LLC
    Inventor: Morris Lee
  • Patent number: 9311826
    Abstract: An energy consumption estimator includes a body motion sensor, a first calculation unit, an acquisition unit, and a second calculation unit. The body motion sensor detects body motion by a user. Based on the body motion detected by the body motion sensor, the first calculation unit calculates the user's total energy consumption. The acquisition unit acquires the user's energy consumption derived from fats and lipids. Based on the energy consumption derived from fats and lipids and on the total energy consumption, the second calculation unit calculates the user's total energy derived from carbohydrates.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 12, 2016
    Assignee: TANITA CORPORATION
    Inventors: Miyuki Kodama, Ayumi Sano, Atsuo Kumekawa
  • Patent number: 9267883
    Abstract: A gas measurement module (16) for use with an airway adapter (22) is configured such that both an emitter (48) and a detector (52, 54) are disposed on the same side of a sampling chamber (46) formed within the airway adapter. Optical elements (56) that guide electromagnetic radiation from the emitter back and forth across the sampling chamber to the detector include at least one toric element. The at least one toric element compensates for a tilted folding mirror positioned on a side of the sampling chamber opposite from the emitter and the detector.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: February 23, 2016
    Assignee: Koninklijke Philips N.V.
    Inventor: James Russell