Measuring Respiratory Flow Impedance Or Lung Elasticity Patents (Class 600/533)
  • Patent number: 10835154
    Abstract: Measurement of airway resistance and/or lung compliance during non forced exhalation is performed using initial occlusion of exhalation followed by removal of the occlusion or opening of a shutter. The measurement device can use a single sensor to measure both pressure and flow. A pressure monitor can detect that exhalation is improperly forced to signal an error or to reject a pressure and flow measurement from a forced exhalation trial.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: November 17, 2020
    Assignee: SPIRO-TECH MEDICAL INC.
    Inventor: Oleg Grudin
  • Patent number: 10813583
    Abstract: A device of the disclosure determines to which of a plurality of sleep stages in a sleep state including a wake stage a sleep state of a subject belongs, based on a sleep state function that is calculated using as variables a respiratory motion feature and a body motion feature that are respectively extracted from respiratory motion index values and body motion index values of the subject measured in time series. The sleep state function is a function including coefficient parameters that are set based on learning data including sleep stage determination results by a measurement of a sleep state for calibration, and respiratory motion features and body motion features that are measured simultaneously with the measurement for calibration.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: October 27, 2020
    Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventor: Hirotaka Kaji
  • Patent number: 10791961
    Abstract: A system for measuring the mechanical impedance of a patient's respiratory system during spontaneous respiratory activity, characterised by comprising a fan; a motor which operates said fan; said motor and said fan being positioned within a cavity; said cavity comprising an initial end and a final end, both providing access to the outside; said cavity presenting an impedance between said initial and said final end of less than 1 cm H2O/L/s; said fan withdrawing air from said final end and providing pressure variations of small amplitude and of frequency >2 Hz to said initial end; said initial end comprising air pressure and air flow measurement means and a connection directly connected to the airway opening.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: October 6, 2020
    Assignee: RESTECH S.R.L.
    Inventors: Pasquale Pio Pompilio, Alessandro Gobbi, Raffaele Dellaca′, Antonio Pedotti
  • Patent number: 10638971
    Abstract: The present invention provides methods for characterizing obstructive sleep apnea (OSA) patients in the treatment of OSA, and devices thereof. The methods comprise measuring polysomnography of said patients; analyzing polysomnography, and determining a characteristic of the polysomnography and selections of suitable treatments based on the patterns.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: May 5, 2020
    Assignee: Somnics, Inc. (USA)
    Inventors: Chung-Chu Chen, Chen-Ning Huang
  • Patent number: 10502723
    Abstract: A breath sensor apparatus for detecting the presence of a compound in an exhaled gas sample, the apparatus comprising a chamber for retaining a gas sample, the chamber defining a gas inlet and a gas outlet, a sensor inside the chamber for analyzing the gas sample, an airflow disrupting element disposed proximate to the sensor to affect the airflow near the device, and an airflow reducing element disposed over the gas outlet to increase the retention time of the gas sample within the chamber.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 10, 2019
    Assignee: Nitto Denko Corporation
    Inventors: Jie Cai, Qianxi Lai, Ekambaram Sambandan, Evan Miller
  • Patent number: 10413244
    Abstract: The present invention provides systems, methods, devices and kits for assessing the level of pulmonary disease in individual lung compartments. A lung compartment comprises a subportion of a lung, such as a lobe, a segment or a subsegment, for example. By measuring individual lung compartments, the level of disease of the pulmonary system may be more precisely defined by determining values of disease parameters reflective of individual subportions or compartments of a lung. Likewise, compartments may be separately imaged to provide further measurement information. Once individual compartments are characterized, they may be compared and ranked based on a number of variables reflecting, for example, level of disease or need for treatment. Such comparison may be aided by simultaneous display of such variables or images on a visual display. Further, the same tests may be performed on the lung as a whole or on both lungs and to determine the affect of the diseased lung compartments on the overall lung performance.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: September 17, 2019
    Assignee: Pulmonx Corporation
    Inventors: Robert Kotmel, Peter Soltesz, Anthony Wondka, Rodney Perkins
  • Patent number: 10376224
    Abstract: A system for analysis of the upper airway has at least two sensors are provided along a flow path leading to the mouth and/or nose of a user. A relation is derived between the two sensor signals, and this is interpreted to detect at least the presence of upper airway obstructions, and preferably also the location and/or extent of such obstructions.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: August 13, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Ronaldus Maria Aarts, Joachim Kahlert, Michel Paul Barbara Van Bruggen, Okke Ouweltjes
  • Patent number: 10327668
    Abstract: The present invention relates to a device, system and a method for determining lung volume and parameters, and in particular, to such a spirometer device, system and method in which a non-occluding shutter is utilized allowing for continuous airflow through the flow tube.
    Type: Grant
    Filed: August 13, 2014
    Date of Patent: June 25, 2019
    Inventors: Leonid Chernyakhovsky, Hanan Itzkovitch, Mark Gaides
  • Patent number: 10165966
    Abstract: Methods for non-invasively and accurately estimating and monitoring resistance and work of breathing parameters from airway pressure and flow sensors attached to the ventilator-dependent patient using an adaptive mathematical model are provided. These methods are based on calculations using multiple parameters derived from the above-mentioned sensors. The resistance and work of breathing parameters are important for: assessing patient status and diagnosis, appropriately selecting treatment, assessing efficacy of treatment, and properly adjusting ventilatory support.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: January 1, 2019
    Assignees: University of Florida Research Foundation, Incorporated, Convergent Engineering, Inc.
    Inventors: Michael J. Banner, Neil Russell Euliano, Andrea Gabrielli, Nawar Nazar Yousif Al-Rawas
  • Patent number: 9901692
    Abstract: A method of treating lung disease, such as asthma or COPD, is provided that includes determining a parameter indicative of a patient's pulmonary mechanics (such as, without limitation, airway resistance or lung compliance), and delivering positive pressure support to the airway of the patient, wherein the pressure level (which may be constant or variable) of the positive pressure support during at least a portion of the inspiratory phase of the patient is determined based on the determined parameter.
    Type: Grant
    Filed: November 21, 2009
    Date of Patent: February 27, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Douglas Mechlenburg, Richard J. Coldren
  • Patent number: 9895081
    Abstract: A method of estimating the upper airway resistance of a patient using a gas delivery system includes delivering a flow of breathing gas to the patient through the patient circuit of the gas delivery system, superimposing an oscillatory pressure on the flow of breathing gas during an expiratory phase of the patient, determining a first amplitude of an oscillatory component of a gas pressure provided to the patient at an end of the expiratory phase, determining a second amplitude of an oscillatory component of a gas flow provided to the patient at the end of the expiratory phase, determining a first resistance value based on the ratio of the first amplitude to the second amplitude, and determining an upper airway resistance value based on the first resistance value.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: February 20, 2018
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: William A. Truschel, Anandi Mahadevan
  • Patent number: 9795756
    Abstract: Described are nasal cannulas that improve the precision of the delivered dose for nitric oxide therapy by reducing the dilution of nitric oxide. The nasal cannulas may reduce the total volume and potential for retrograde flow during nitric oxide therapy through the design of the specific dimensions of the flow path and/or having check valves in the nitric oxide delivery line and/or having a flapper or umbrella valve dedicated to nitric oxide delivery. The nasal cannulas may also use materials that limit oxygen diffusion through the cannula walls. The nosepiece for these cannulas may be manufactured by a molding technique.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: October 24, 2017
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Craig Flanagan, Simon Freed, John Klaus, Thomas Kohlmann, Martin D. Meglasson, Manesh Naidu, Parag Shah
  • Patent number: 9649050
    Abstract: The acoustic impedance of the respiratory system can be inferred from oscillations that are generated in an airway of a subject. The impedance describes the frequency-dependent relation between the resulting oscillations in flow and pressure. When the impedance varies from inspiration to expiration, it has to be estimated with a high time resolution. A method is provided that reliably estimates the impedance in time intervals that are short enough for physiological purposes. A simple version of the uncertainty principle has been derived for discrete time and frequency. A discrete time-frequency transform has been developed that gives an optimal time-frequency resolution according to this principle. The transform is orthonormal, which permits an analysis of variance in the discrete time-frequency domain. The impedance follows from bivariate least-squares analysis in the time-frequency domain, under the assumption that noise is present in both flow and pressure.
    Type: Grant
    Filed: November 24, 2010
    Date of Patent: May 16, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Joost Gerard Van Den Aardweg
  • Patent number: 9364168
    Abstract: A method of diagnosing an air leak in a lung compartment of a patient may include: advancing a diagnostic catheter into an airway leading to the lung compartment; inflating an occluding member on the catheter to form a seal with a wall of the airway and thus isolate the lung compartment; measuring air pressure within the lung compartment during multiple breaths, using the diagnostic catheter; displaying the measured air pressure as an air pressure value on a console coupled with the diagnostic catheter; and determining whether an air leak is present in the lung compartment based on the displayed air pressure value during the multiple breaths.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: June 14, 2016
    Assignee: PulmonX Corporation
    Inventor: Surag Mantri
  • Patent number: 9259542
    Abstract: A differential pressure transducer determines pressure differentials between respiratory airflows and ambient airflows. Another determines pressure differentials between respiratory airflows and interface airflows. And another determines pressure differentials between i) respiratory airflows received from a subject and ii) interface airflows received from an area near a cannula. Corresponding respiratory monitoring methods also determine the same.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: February 16, 2016
    Assignee: General Electric Company
    Inventors: Jaron Matthew Acker, Robert Quin Yew Tham, Kristopher John Bilek, Andreas Tzanetakis
  • Patent number: 9192323
    Abstract: The invention relates to a system for detecting respiratory muscle activity of a patient (1) receiving assisted breathing, which is connected to an assistance device (2) by a pneumatic circuit (3). Said system is characterised in that it comprises: a means (4, 5) for acquiring air pressure and flow signals in the pneumatic circuit (3), sent to a means (6) for continuously estimating the theoretical air pressure expected in the pneumatic circuit in absence of respiratory muscle activity from the patient; and a means (7) for comparing estimated and actual theoretical pressures in order to continuously detect a pressure differential showing respiratory muscle activity in the patient.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: November 24, 2015
    Assignee: ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Laurent Heyer, Pierre Baconnier
  • Publication number: 20150148699
    Abstract: An apparatus may include a sensing circuit and a processor. The sensing circuit is configured to generate a sensed physiological signal, wherein the physiological signal includes respiration information of a subject. The processor includes an end expiratory volume (EEV) module configured to determine a value of EEV of the subject using the sensed physiological signal, and a lung hyperinflation detection module configured to generate an indication of lung hyperinflation of the subject according to the value of EEV and provide the indication to at least one of a user or process.
    Type: Application
    Filed: November 11, 2014
    Publication date: May 28, 2015
    Inventors: Ramesh Wariar, Kenneth C. Beck, Yi Zhang, Aiden Flanagan, Bryan Allen Clark
  • Patent number: 9022947
    Abstract: Continuous measurement of breathing impedance with extremely high precision is enabled by executing noise elimination. A loudspeaker applies an air vibration pressure by an oscillation wave to an oral cavity, the oscillation wave being obtained by frequency-cuffing so executed that the oscillation wave has only the frequency component that is left after the culling is executed from a plurality of different frequencies and being generated by a pulse signal for pulse drive with pulses made positive and negative separately in correspondence to the time of exhalation and the time of inhalation. A pressure inside the oral cavity is detected and a breathing flow is detected, and a signal obtained by the detection is Fourier-transformed to obtain a spectrum. Analysis of the spectrum is performed to obtain breathing impedance.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: May 5, 2015
    Assignees: Chest M.I. Incorporated, Tohoku Techno Arch Co., Ltd.
    Inventors: Hajime Kurosawa, Yoshio Shimizu, Toshiaki Hoki
  • Publication number: 20150119743
    Abstract: An actuator (10, 10?, 10?) is disclosed. The actuator (10, 10?, 10?) is connected to a structural ground (12, 12?, 12?) of a forced oscillation technique device (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000). The actuator (10, 10?, 10?) includes an electrical power source (16, 16?, 16?); a control device (17, 17?, 17?) connected to the electrical power source (16, 16?, 16?); a first portion (14a, 14a?, 14a?) including active material connected to the electrical power source, and a second portion (14b, 14b?, 14b?) including non-active, passive material connected to the first portion (14a, 14a?, 14a?). The first portion (14a, 14a?, 14a?) includes at least one plate-shaped member (18, 18?, 18?). The second portion (14b, 14b?, 14b?) includes a ring member (24, 24?, 24?) connected to and circumscribing a mesh screen (26, 26?, 26?). A forced oscillation technique device (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000) is also disclosed.
    Type: Application
    Filed: May 1, 2013
    Publication date: April 30, 2015
    Inventors: Geoffrey N. Maksym, Lucas Posada, Hamed Hanafialamdari
  • Publication number: 20150099994
    Abstract: There is provided a method of monitoring the lung function of a patient, the method comprising determining one or both of an inhalation time and a rest time for a patient that is using a respiratory apparatus, the one or both of an inhalation time and a rest time for the patient being determined from measurements obtained from the respiratory apparatus, wherein the inhalation time is the amount of time for which the patient inhales through the respiratory apparatus, and the rest time is the amount of time between the end of an exhalation and the start of the next inhalation; and analyzing the determined one or both of the inhalation time and rest time to determine an indication of the lung function of the patient.
    Type: Application
    Filed: May 28, 2013
    Publication date: April 9, 2015
    Inventors: Timothy Spencer, Anthony Dyche, Ian Philip Rabbetts
  • Publication number: 20150073291
    Abstract: The identification of obstructed breathing, including an apnea condition and a hypopnea condition, is disclosed. A signal representative of a flow rate of therapeutic gas being delivered to the patient is received. A peak flow value and a minimum flow value over a predetermined time window encompassing a plurality of respiration cycles is derived. A polynomial difference equation from the peak flow values and the minimum flow values is generated, and a respiration index from a minimum of the polynomial difference equation is derived. The apnea and/or hypopnea condition is indicated based upon a comparison of the respiration index to a predefined obstruction threshold over a predefined obstruction time period.
    Type: Application
    Filed: September 6, 2013
    Publication date: March 12, 2015
    Applicant: Breathe Technologies, Inc.
    Inventors: Leonardo Alberto Baloa Welzien, Enrico Bambrilla, Samir S. Ahmad
  • Publication number: 20150057559
    Abstract: Methods and apparatuses are described for direct rapid measurement of pulmonary flow resistance. A measurement of a first pressure in a gas-tight chamber is received from a pressure sensor when a gas output port of the chamber is closed, a patient is blowing into a gas inlet of the chamber at a given pressure, and a gas-flow path between the inlet and output port has a resistance value. A measurement of a second pressure in the chamber is received from the pressure sensor and a measurement of gas flow through the chamber is received from a gas flow sensor when the output port is opened and the patient is blowing into the inlet to maintain the given pressure relatively constant. A pulmonary flow resistance is computed based upon the measurement of the first pressure, the measurement of the second pressure, the resistance value, and the measurement of gas flow.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 26, 2015
    Inventor: Yoram Palti
  • Publication number: 20150045687
    Abstract: This disclosure describes systems and methods for monitoring and evaluating data associated with ventilatory parameters to detect expiratory airflow limitation in a ventilated patient. For example, a ventilator may monitor flow and/or pressure during ventilation of the patient. Based on the flow and/or pressure measurements, or ventilatory data derived therefrom, the ventilator may calculate expiratory resistance. Moreover, the ventilator may trend expiratory resistance over time to produce an expiratory resistance waveform. In embodiments, the ventilator may calculate the slope of the expiratory resistance waveform during an initial part of exhalation. If the slope of the expiratory resistance waveform during the initial part of exhalation breaches a defined slope threshold, the ventilator may determine that the patient exhibits expiratory airflow limitation.
    Type: Application
    Filed: August 7, 2013
    Publication date: February 12, 2015
    Applicant: Covidien LP
    Inventors: Richard Nakai, Warren Sanborn, David Hyde
  • Publication number: 20150011905
    Abstract: A single respiratory cycle flow limitation detection method is disclosed. A patient gas delivery signal is received from one or more sensors in pneumatic communication with a ventilation source and a patient ventilation interface to a patient airway. The patient gas delivery signal is representative of a measure of therapeutic gas being delivered to the patient airway at a given time instant, and spans the single patient respiratory cycle. A second derivative of the patient gas delivery signal is generated and a total number of zero crossings therein are counted. These zero crossings are representative of an inflection change in the patient gas delivery signal. A flow limitation indication corresponding to the identified flow limitation is generated when there are at least two zero crossings in the second derivative of the patient gas delivery signal. An angle of deformation representing early, late, or mid-cycle obstruction onsets is generated.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 8, 2015
    Inventors: Leonardo Alberto Baloa Welzien, Samir S. Ahmad
  • Patent number: 8929623
    Abstract: A computer for aiding determination of Obstructive Sleep Apnea (OSA) includes a storage device storing with a medical image and a central processing unit (CPU). The CPU executes a method for aiding determination of OSA. The method for aiding determination of OSA includes the following steps. The medical image is obtained. An upper airway model is established. A narrowest cross-section and a nasopharyngeal boundary cross-section are defined in the airway model. A cross-sectional area of the narrowest cross-section and a cross-sectional area of the nasopharyngeal boundary cross-section are calculated. A stenosis rate is calculated according to the cross-sectional area of the narrowest cross-section and the cross-sectional area of the nasopharyngeal boundary cross-section. The stenosis rate is provided. In addition, in the method for aiding determination of OSA, a respiratory flow field simulation may be further performed to obtain and provide a flow field pressure distribution of the upper airway model.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: January 6, 2015
    Assignee: National Applied Research Laboratories
    Inventors: Hung Ta Hsiao, Sheng Chuan Wang, Franco Lin, Lung Cheng Lee, Chih Min Yao, Ning Hung Chen, Chung Chih Yu
  • Publication number: 20150005658
    Abstract: An apparatus for determining a respiratory condition, includes: a signal acquiring section which is configured to acquire a signal corresponding to a respiratory flow of a subject; a first index producing section which is configured to produce a first index related to the respiratory flow of the subject obtained from the signal; a second index producing section which is configured to produce a second index related to a respiratory demand of the subject predicted from the first index; a third index producing section which is configured to produce a third index related to a respiratory effort of the subject based on the first index and the second index; and an outputting section which is configured to output the third index.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 1, 2015
    Applicants: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Yukio NONAKA, Shiroh ISONO, Tsuyoshi SHIMIZU
  • Publication number: 20140350429
    Abstract: A method of estimating the upper airway resistance of a patient using a gas delivery system includes delivering a flow of breathing gas to the patient through the patient circuit of the gas delivery system, superimposing an oscillatory pressure on the flow of breathing gas during an expiratory phase of the patient, determining a first amplitude of an oscillatory component of a gas pressure provided to the patient at an end of the expiratory phase, determining a second amplitude of an oscillatory component of a gas flow provided to the patient at the end of the expiratory phase, determining a first resistance value based on the ratio of the first amplitude to the second amplitude, and determining an upper airway resistance value based on the first resistance value.
    Type: Application
    Filed: September 11, 2012
    Publication date: November 27, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: William A. Truschel, Anandi Mahadevan
  • Publication number: 20140336484
    Abstract: Methods and systems for targeting, accessing and diagnosing diseased lung compartments are disclosed. The method comprises introducing a diagnostic catheter with an occluding member at its distal end into a lung segment via an assisted ventilation device; inflating the occluding member to isolate the lung segment; and performing a diagnostic procedure with the catheter while the patient is ventilated. The proximal end of the diagnostic catheter is configured to be attached to a console. The method may also comprise introducing the diagnostic catheter into the lung segment; inflating the occluding member to isolate the lung segment; and monitoring blood oxygen saturation. The method may further comprise introducing the diagnostic catheter into the lung segment; determining tidal flow volume in the lung segment; determining total lung capacity of the patient; and determining a flow rank value based on the tidal flow volume of the lung segment and the total lung capacity.
    Type: Application
    Filed: July 23, 2014
    Publication date: November 13, 2014
    Inventors: Surag Mantri, Srikanth Radhakrishnan
  • Patent number: 8880171
    Abstract: A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: November 4, 2014
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Jaeho Kim, Quan Ni
  • Patent number: 8876728
    Abstract: The lung compliance of a subject that is at least partially self-ventilating is determined. The quantification of lung compliance may be an estimation, a measurement, and/or an approximate measurement. The quantification of lung compliance may be enhanced over conventional techniques and/or systems for quantifying lung compliance of self-ventilating subjects in the lung compliance may be quantified relatively accurately without an effort belt or other external sensing device that directly measures diaphragmatic muscle pressure, and without requiring the subject to manually control diaphragmatic muscle pressure. Quantification of lung compliance may be a useful tool in evaluating the health of the subject, including detection of fluid retention associated with developing acute congestive heart failure.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: November 4, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Leonardo Alberto Baloa Welzien, Nathan Francis O'Connor
  • Publication number: 20140309546
    Abstract: Airway impedance of a subject using a respiratory treatment device can be measured, in accordance with one or more embodiments. A conduit is configured to communicate a flow of inhaled gas and a flow of exhaled gas to and from an airway of the subject using the respiratory treatment device. A first valve is disposed within the conduit and configured to affect the flow of exhaled gas. One or more sensors are disposed within the conduit and are configured to provide a signal conveying information associated with one or more characteristics of gas exhaled by the subject while the flow of exhaled gas is affected or unaffected by the first valve. An airway impedance monitoring module can be executed by a processor to determine an impedance metric of the airway of the subject based on the information conveyed by the signal provided by the one or more sensors.
    Type: Application
    Filed: December 18, 2012
    Publication date: October 16, 2014
    Inventors: Alberto Fazzi, Teunis Johannes Vink, Dirk Erneset Von Hollen
  • Publication number: 20140296730
    Abstract: A breathing apparatus (1) is disclosed that is adapted to determine a transpulmonary pressure in a patient (125) when connected to said breathing apparatus. A control unit (105) is operable to set a first mode of operation for ventilating said patient with a first Positive End Expiratory Pressure (PEEP) level; set a second mode of operation for ventilating said patient with a second PEEP level starting from said first PEEP level; and determine said transpulmonary pressure (Ptp) based on a change in end-expiratory lung volume (?EELV) and a difference between said first PEEP level and said second PEEP level (?PEEP). Furthermore, a method and computer program are disclosed.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 2, 2014
    Applicant: M Stenqvist AB
    Inventor: Ola Stendqvist
  • Publication number: 20140276173
    Abstract: Methods for non-invasively and accurately estimating and monitoring resistance and work of breathing parameters from airway pressure and flow sensors attached to the ventilator-dependent patient using an adaptive mathematical model are provided. These methods are based on calculations using multiple parameters derived from the above-mentioned sensors. The resistance and work of breathing parameters are important for: assessing patient status and diagnosis, appropriately selecting treatment, assessing efficacy of treatment, and properly adjusting ventilatory support.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 18, 2014
    Applicants: Convergent Engineering, Inc., University of Florida Research Foundation Incorporated
    Inventors: Michael J. BANNER, Neil Russel EULIANO, Andrea GABRIELLI, Nawar Nazar Yousif AL-RAWAS
  • Publication number: 20140276131
    Abstract: An apparatus includes a computing device that includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include receiving a signal representative of electrical impedance in a chest of a patient, and, receiving a signal representative of the motion of chest compressions performed on the patient during a cardiopulmonary resuscitation (CPR) treatment. The operations also include processing the received signal representative of the motion of chest compressions to determine one or more characteristics of the motion, and, processing the received signal representative of the electrical impedance to determine parameters relevant to a production of a signal representative of airflow activities of the patient. Operations also include modifying the one or more determined parameters based on the one or more determined characteristics of the motion to produce the signal representative of airflow activities of the patient.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 18, 2014
    Inventors: Frederick J. Geheb, Gary A. Freeman, Ulrich Herken
  • Patent number: 8834379
    Abstract: A system for providing an indication of cardiovascular function, includes a respiration input (1) for receiving a respiration-related signal indicative of a physical property of respiration gases administered to a patient. A hemodynamic input (2) is provided for receiving a hemodynamic-related signal indicative of a hemodynamic property. An inspiration detector (3) is provided for processing the respiration-related signal to detect times of inspiration and a measure of the size of the inspiration. A correlator (5) is provided for correlating the sizes of inspiration with the hemodynamic-related signal, to obtain the indication of cardiovascular function. The respiration-related signal is indicative of inspiration pressure, inspiration volume, or inspiration flow. The hemodynamic-related signal is indicative of blood pressure.
    Type: Grant
    Filed: March 25, 2011
    Date of Patent: September 16, 2014
    Assignee: Dräger Medical GmbH
    Inventor: Marc Van Houwelingen
  • Patent number: 8831717
    Abstract: The invention relates to estimation of a patient's propensity to suffer from symptomatic hypotension during extracorporeal blood treatment. An electromagnetic test signal, which is applied over a thoracic region of the patient via at least one transmitter electrode. A result signal produced in response to the test signal is received via at least one receiver electrode on the patient. A test parameter is derived based on the result signal. The test parameter expresses a fluid status of the thoracic region of the patient, and it is determined whether the test parameter fulfills an alarm criterion. If the test parameter fulfills an alarm criteria, an alarm signal is generated. This signal indicates that the patient is hypotension prone, and that appropriate measures should be taken.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: September 9, 2014
    Assignee: Gambro Lundia AB
    Inventors: Kristian Solem, Bo Olde
  • Publication number: 20140235959
    Abstract: Ventilatory systems and methods are disclosed for detecting weaning readiness of a patient. In one aspect the method includes the steps of collecting patient data; analyzing the collected patient data to generate at least one patient parameter; comparing the at least one patient parameter to predetermined weaning readiness threshold criteria; and providing an advisory proposition to a clinician indicating a readiness of the patient to start a weaning trial if the at least one patient parameter meets the weaning readiness threshold criteria. The weaning trial may additionally or alternatively be automatically executed if the at least one patient parameter meets the weaning readiness threshold criteria.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 21, 2014
    Applicant: Covidien LP
    Inventors: Mehdi Jafari, Peter Doyle
  • Publication number: 20140228657
    Abstract: A system and method for monitoring respiration of a user, comprising: a respiration sensing module including a sensor configured to detect a set of respiration signals of the user based upon movement resulting from the user's respiration; a supplementary sensing module comprising an accelerometer and configured to detect a set of supplemental signals from the user; an electronics subsystem comprising a power module configured to power the system and a signal processing module configured to condition the set of respiration signals and the set of supplemental signals; a housing configured to facilitate coupling of the respiration sensing module and the supplementary sensing module to the user; and a data link coupled to the electronics subsystem through the housing and configured to transmit data generated from the set of respiration signals and the set of supplemental signals, thereby facilitating monitoring of the user's respiration.
    Type: Application
    Filed: February 6, 2014
    Publication date: August 14, 2014
    Applicant: Spire, Inc.
    Inventors: Jonathan Paul K. Palley, Zhao Zhao
  • Publication number: 20140221865
    Abstract: An electric impedance tomography device with chest electrodes, a display and a control and analyzing unit to determine a time series of a global ventilation curve from the sequence of reconstructed matrices as a time series of the mean impedance change or of a measured respiration volume, to divide an inspiration or expiration phase into a number of steps of equal volume change, to determine the times corresponding to these steps, to determine the change in local impedance between these times for each image element, the ratio of this local change in impedance to the global equal volume change to form a local sequence of relative impedance changes of the image element as a function of the steps of equal volume change, to determine a scalar indicator characteristic as a function of the steps of equal volume change and to display each image element based on the respective scalar indicator.
    Type: Application
    Filed: February 4, 2014
    Publication date: August 7, 2014
    Applicant: Dräger Medical GmbH
    Inventors: Yvo GÄRBER, Ola STENQVIST
  • Publication number: 20140221864
    Abstract: An EIT device with a plurality of electrodes, which can be arranged about the chest of a patient, with a control and analyzing unit for feeding electrode pairs of a set of electrodes to record a voltage or current signal as a measured signal with electrode pairs acting consecutively as the feeding electrode pair to provide a matrix of image elements. A time series of the impedance change from the sequence of reconstructed matrices over at least one breath is obtained and compared to a determined time series of the mean impedance change or a time series of a measured respiration volume, by calculating for each image element a scalar value as an indicator of a deviation. The control and analyzing unit assesses and marks the corresponding image element as being non-ventilated if the indicator of the deviation meets a preset threshold value criterion.
    Type: Application
    Filed: July 16, 2013
    Publication date: August 7, 2014
    Inventor: Yvo GÄRBER
  • Publication number: 20140200476
    Abstract: In a respiratory apparatus for treatment of sleep apnea and other disorders associated with an obstruction of a patient's airway and which uses an airflow signal, an obstruction index is generated which detects the flattening of the inspiratory portion of the airflow. The obstruction index is used to differentiate normal and obstructed breathing. The obstruction index is based upon different weighting factors applied to sections of the airflow signal thereby improving sensitivity to various types of respiration obstructions.
    Type: Application
    Filed: March 14, 2014
    Publication date: July 17, 2014
    Applicant: RESMED LIMITED
    Inventor: Peter John Deacon Wickham
  • Patent number: 8753286
    Abstract: The invention relates to a spirometer for measuring pulmonary respiration of a test subject, comprising a body and a sensor unit, wherein the sensor unit can be interchanged with further sensor units. In a corresponding method, such a spirometer is operated with a sensor unit and the sensor unit is subsequently interchangeably replaced by a further sensor unit.
    Type: Grant
    Filed: December 23, 2010
    Date of Patent: June 17, 2014
    Assignee: sendsor GmbH
    Inventors: Alexander Scholz, Murat Gül
  • Patent number: 8747330
    Abstract: The invention provides a system for measuring respiratory rate (RR) from a patient. The system includes an impedance pneumography (IP) sensor, connected to at least two electrodes, and a processing system that receives and processes signals from the electrodes to measure an IP signal. A motion sensor (e.g. an accelerometer) measures at least one motion signal (e.g. an ACC waveform) describing movement of a portion of the patient's body to which it is attached. The processing system receives the IP and motion signals, and processes them to determine, respectfully, frequency-domain IP and motion spectra. Both spectra are then collectively processed to remove motion components from the IP spectrum and determine RR. For example, during the processing, an algorithm determines motion frequency components from the frequency-domain motion spectrum, and then using a digital filter removes these, or parameters calculated therefrom, from the IP spectrum.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: June 10, 2014
    Assignee: Sotera Wireless, Inc.
    Inventors: Matt Banet, Marshal Dhillon, Devin McCombie
  • Patent number: 8740750
    Abstract: In at least one embodiment, a device for controlling and/or regulating a training and/or rehabilitation unit comprises a training and/or rehabilitation unit, a sensor unit having sensors for determining oxygen concentration and for determining carbon dioxide concentration, a control unit for the sensors, a microcontroller in the control unit for controlling the heating power of heating elements of the sensors, depending on breath flow volume, for maintaining constant sensor temperatures, and a resistance and/or braking arrangement of the training and/or rehabilitation unit that can be controlled and/or regulated based on a breathing gas composition determined by the sensor unit. The device can be used to increase endurance, preferably by way of altitude training.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: June 3, 2014
    Inventor: Ulrich Jerichow
  • Patent number: 8728002
    Abstract: A system and method of calculating an accurate estimate of pulmonary mechanics of a patient, including but not limited to compliance, resistance, and plateau pressure without modification of ventilator flow pattern. The accurate estimation of pulmonary mechanics is derived from airway pressure and flow sensors attached to the patient using novel mathematical models. These estimated figures for pulmonary mechanics (respiratory system compliance and resistance) are important for monitoring patient treatment efficacy during mechanical ventilation and ensuring alveoli do not over distend to avoid baro- and/or volutrauma, especially in patients with restrictive lung diseases. The subject method of calculating these accurate estimated figures for pulmonary mechanics is based on linear or non-linear calculations using multiple parameters derived from the above-mentioned sensors.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: May 20, 2014
    Assignees: University of Florida Research Foundation, Inc., Convergent Engineering, Inc.
    Inventors: Nawar Nazar Yousif Al-Rawas, Andrea Gabrielli, Neil Russell Euliano, Michael Joseph Banner
  • Patent number: 8728059
    Abstract: The disclosed embodiments relate to a system and method for assuring validity of monitoring parameters in combination with a therapeutic device. An exemplary embodiment of the present technique comprises perturbing a treatment administered to a patient, measuring at least one parameter of the patient reflecting the underlying physiological state and associated with the treatment, and comparing the perturbations of the treatment to measurements of the at least one parameter to determine if the perturbations to the treatment are reflected by the parameter.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: May 20, 2014
    Assignee: Covidien LP
    Inventors: Edward Karst, Clark R. Baker, Jr.
  • Patent number: 8721560
    Abstract: A method for use in an implantable medical device comprises the steps of monitoring respiration with an amplifier having a gain, generating a moving apneic threshold based on recent respiration cycles, accumulating differences between amplitudes of respiration cycles and the moving apnea detection threshold and comparing the accumulated differences against an apnea detection threshold to detect the onset of an episode of apnea. The method further comprises measuring respiration levels upon detecting the onset of apnea, confirming the episode of apnea based upon the respiration levels measured upon detecting the onset of apnea; and adjusting one of the gain of the amplifier and the apnea detection threshold so that the time from the detection of onset of apnea to the time of confirmation of the episode of apnea is within a predetermined time range following the detection of the onset of apnea.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: May 13, 2014
    Assignee: Pacesetter, Inc.
    Inventor: Steve Koh
  • Publication number: 20140121553
    Abstract: This disclosure describes systems and methods for monitoring and evaluating ventilatory parameters, analyzing those parameters and providing useful notifications and recommendations to clinicians. That is, modern ventilators monitor, evaluate, and graphically represent a myriad of ventilatory parameters. However, many clinicians may not easily identify or recognize data patterns and correlations indicative of certain patient conditions, changes in patient condition, and/or effectiveness of ventilatory treatment. Further, clinicians may not readily determine appropriate ventilatory adjustments that may address certain patient conditions and/or the effectiveness of ventilatory treatment. Specifically, clinicians may not readily detect or recognize the presence of Auto-PEEP during volume ventilation of a non-triggering patient.
    Type: Application
    Filed: January 3, 2014
    Publication date: May 1, 2014
    Applicant: Covidien LP
    Inventors: Gary Milne, Kirk Hensley, Peter R. Doyle
  • Patent number: 8702617
    Abstract: Respiratory diseases related to gastroesophageal reflux disease in a patient are diagnosed by detecting esophageal or pharyngeal impedance and pH in the patient, detecting oxygen saturation in the patient, and diagnosing the respiratory diseases from the esophageal or pharyngeal impedance, the pH, and the oxygen saturation.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: April 22, 2014
    Assignee: University of Rochester
    Inventor: Jeffery H. Peters
  • Patent number: 8688214
    Abstract: A system comprising implantable device, the implantable medical device including an intrinsic cardiac signal sensor, an impedance measurement circuit configured to apply a specified current to a transthoracic region of a subject and to sample a transthoracic voltage resulting from the specified current, and a processor coupled to the intrinsic cardiac signal sensor and the impedance measurement circuit. The processor is configured to initiate sampling of a transthoracic voltage signal in a specified time relation to a fiducial marker in a sensed intrinsic cardiac signal, wherein the sampling attenuates or removes variation with cardiac stroke volume from the transthoracic voltage signal, and determine lung respiration using the sampled transthoracic voltage signal.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: April 1, 2014
    Assignee: Cardiac Pacemakers. Inc.
    Inventors: Jaeho Kim, Quan Ni