Abstract: A breath condensate collection apparatus comprising a central chamber, a breath input assembly, a plunger assembly and a breath condensate collection port. The central chamber has inner and outer side walls with a coolant material sealed in between. The breath input assembly is disposed on the side of the central chamber in fluid communication with the chamber interior. The plunger assembly has a piston, slidably disposed in the chamber, and a handle extending from a first end of the chamber. The collection port is disposed at the second end of the central chamber in fluid communication with the interior of the chamber. Obstructive structures may be arranged in the chamber interior for increasing the surface area on which condensate may form. The apparatus may also include an outlet assembly that may be removed and replaced with a sampling well into which the condensate may be washed with a buffer solution.

Abstract: In accordance with the present invention, there is provided various tubing arrangements and an associated Y-connector which may be used to facilitate the operative interface of the mask to a ventilator within a ventilation system. The tubing arrangement may comprise a pair of bi-lumen tubes. One end of each of the bi-lumen tubes is fluidly connected to the mask, with the opposite end being fluidly connected to the Y-connector. The Y-connector is in turn fluidly connected to one end of either a tri-lumen tube or a quad-lumen tube also included in the tubing arrangement, the opposite end of such tri-lumen tube or quad-lumen tube being fluidly connected to the ventilator. The Y-connector is uniquely configured to fluidly connect certain lumens of the tri-lumen tube or the quad-lumen tube to dedicated, corresponding ones of the lumens included in respective ones of the bi-lumen tubes, and to further allow for the selective detachment of the tri-lumen tube or the quad-lumen tube from the bi-lumen tubes.

Abstract: A breath condensate collection apparatus comprising a central chamber, a breath input assembly, a plunger assembly and a breath condensate collection port. The central chamber has inner and outer side walls with a coolant material sealed in between. The breath input assembly is disposed on the side of the central chamber in fluid communication with the chamber interior. The plunger assembly has a piston, slidably disposed in the chamber, and a handle extending from a first end of the chamber. The collection port is disposed at the second end of the central chamber in fluid communication with the interior of the chamber. Obstructive structures may be arranged in the chamber interior for increasing the surface area on which condensate may form. The apparatus may also include an outlet assembly that may be removed and replaced with a sampling well into which the condensate may be washed with a buffer solution.

Abstract: In accordance with the present invention, there is provided a mask for achieving positive pressure mechanical ventilation (inclusive of CPAP, ventilator support, critical care ventilation, emergency applications), and a method for a operating a ventilation system including such mask. The mask of the present invention includes a piloted exhalation valve that is used to achieve the target pressures/flows to the patient. The pilot for the valve may be pneumatic and driven from the gas supply tubing from the ventilator. The pilot may also be a preset pressure derived in the mask, a separate pneumatic line from the ventilator, or an electro-mechanical control. The mask of the present invention may further include a heat and moisture exchanger (HME) which is integrated therein.

Abstract: An automatic breath collecting and sampling system, which is preferably carried by the subject, or otherwise kept with him or near him, for the recommended duration of the collection period. The system collects samples in separate switchable containers, either at predetermined time intervals, or in response to an automatic stimulus, which could be related to the breath content itself, or to another physiological signal, such as the subject s pulse rate, breath rate, blood pressure, or temperature, or in response to a signal related to an environmental effect, such as the presence of a strong concentration in the air of a foreign gas, which could be detected by an electrochemical sensor, or manually by the subject after being prompted by the system. After collection of the requisite number of separate containers, they may be detached and sent for analysis or other treatment.

Abstract: A method of determining the respiratory function of a subject is disclosed, the method comprising measuring the concentration of water vapor in the gas stream exhaled by the subject, and from the measured water vapor concentration determining the respiratory function of the subject. Mathematical techniques for analyzing the data obtained from the measurement of concentrations of gaseous components in an exhaled gas stream are also disclosed and their use in determining the lung function of a subject.

Abstract: There is provided herein a dryer polymer substance including a hetero-phase polymer composition including two or more polymers wherein at least one of the two or more polymers include sulfonic groups, wherein the substance is adapted to pervaporate a fluid. The fluid may include water, water vapor or both. There is also provided herein a process for the preparation of a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both) the process includes mixing two or more polymers, wherein at least one of the two or more polymers may include groups which are adapted to be sulfonated, to produce a hetero-phase polymer composition and processing the polymer blend into a desired form.

Abstract: The present invention provides a method for measuring FeNO in a subject, wherein the FeNO data derived from a subject patient is normalized to compensate for variations of FeNO with flow rate.

Abstract: This invention relates to a breathing sensing device, comprising a diaphragm (100) having a first pressure chamber (120) on one side and a second pressure chamber (121) on a second side, wherein said first and second pressure chambers (120, 121) are connected to a system pressure (L1) by means of flow passages (143, 153) having different cross sectional passage area (Ar, Af) arranged to facilitate detection of a pressure drop due to breathing, wherein the relation of cross sectional passage area between the cross sectional passage area (Ar) providing a restricted flow passages (143) to and/or from the second pressure chamber (121) is in the range of 1/50- 1/200 in relation to the cross sectional passage area (A f) providing a flow passage to and/or from the first pressure chamber (120).

Abstract: The present invention includes an apparatus and a method for testing exhaled breath condensate for at least one biometric marker, including a substrate for collecting exhaled breath condensate, the substrate capable of being brought to a temperature below a dew point of vapor in exhaled breath, a collector for retaining the substrate and for receiving a biometric marker reagent. The invention may further include receiving exhaled breath in a collector, the collector comprising a substrate, the substrate being at a temperature below a dew point of vapor in exhaled breath, collecting the exhaled breath condensate on the substrate, and bringing a biometric marker reagent in contact with the substrate.

Abstract: An exhaled breath temperature (EBT) monitor that has a synchronized two-door shutter with movable individual doors coupled with a timer in order that only a pre-determined portion of the exhalation gas stream is selected for temperature monitoring. The doors can be either in a first position, whereby the shutter passes the portion of exhaled gas direct to atmosphere with no measurement of temperature, or in a second position, whereby the shutter passes the portion of exhaled gas to a chamber for measurement of temperature by a thermal core with a temperature sensor/reader.

Abstract: A breath collection apparatus is provided that includes a facemask to cover the nose and mouth of a patient to direct the breath into a collection bag or collection vial. A valve assembly containing a flexible valve member is provided between the facemask and the collection container to direct a breath sample to the collection container while permitting fresh air to enter the facemask upon inhalation. Between the valve assembly and the collection container is a collection container attachment fitting for engaging the valve assembly with the collection container. The collection container attachment fitting can be a two-piece fitting designed to accommodate a flexible bladder used to accumulate multiple breath samples for subsequent delivery to the collection container.

Abstract: The present invention relates to a lung function assessment system, a mechanical ventilator and method that allows simultaneously measurements of lung function and provides simultaneously mechanical ventilation to multiple subjects requiring one source of gas.

Abstract: A device for fractionally collecting contents of exhaled air by changing the state of matter of the contents by means of the Joule-Thomson effect arising during the expansion of pressurized gas. The temperature of the exhaled air conducted in a flow channel is lowered, because of the cooling of the expanding gas, to a temperature that is suitable for condensing the contents in the exhaled air flow. This device and method provides a more efficient means by which condensate can be separated from exhaled air in comparison to conveying exhaled air along a cooling surface for the condensation of the contents, as a result of which condensation of the contents occurs only in the area of these cooling surfaces, so that several breath cycles are required for the collection of sufficient condensate for analysis.

Abstract: A patient interface in accordance with one embodiment of the present invention is configured to be at least partially carried by a patient and to receive gas exhaled by the patient. The patient interface includes first and second cannula tubes each having a first end and a second end, the first ends are configured to be inserted into the nostrils of a patient, the first and second cannula tubes are configured to direct exhaled gas from the patient from the first ends to said second ends. The patient interface also includes first and second sensors positioned near the second ends, and the first and second sensors are configured to provide first and second signals based upon the gas, wherein the first and second signals are indicative of a physiological parameter of the patient. The patient interface also includes a communications link configured to provide the signal to a physiological monitor.

Abstract: An improved evacuated air chamber having a plurality of generally flat exterior walls, a closed end, and an open end wherein the open end is provided with a resealable stopper and septum; an impervious disc may be provided between the septum and the tube interior.

Abstract: A system for collecting an exhaled breath sample and exhaled breath aerosol from a subject includes a condensation chamber having an outer wall defining an interior space. The outer wall has an inlet port and an outlet port therethrough in fluid communication with the interior space. The inlet port is placeable in fluid communication with an exhaled breath sample of the subject. A condensation element is positioned within the condensation chamber interior space and has a shape tapering downwardly toward a bottom tip thereof. A condensation of fluid on the condensation element is enhanced through various elements. A collection area is positioned within the condensation chamber's interior space beneath the condensation element bottom tip. The collection area is for collecting condensate accumulating on an outer surface of the condensation element and dropping from the tip thereof.

Abstract: Arrangement in a patient breathing tube and a patient breathing tube. The breathing tube is provided with a patient end and a ventilator end. The arrangement comprises a sampling conduit having a sampling tip provided at a pre-determined point of the patient end to define a sampling point. The arrangement further comprises a support structure locating the sampling tip of the sampling conduit apart from the inner surface of the patient breathing tube.

Abstract: A system is provided for capturing motion of a moving object via a plurality of motion sensor modules placed on various body segments. The sensor modules capture both 3D position and 3D orientation data relating to their respective body segments, thereby gathering motion data having six degrees of freedom with respect to a coordinate system not fixed to the body. Each body sensor collects 3D inertial sensor data and, optionally, magnetic field data. In embodiments, either DSP circuitry within the sensor modules or an external computing device, processes the sensor data to arrive at orientation and position estimates by using an estimation algorithm, such as a Kalman filter or a particle filter. The processing includes biomechanical model constraints that allow flexibility in the joints and provide characteristics for various joint types. To improve estimation accuracy, the system may be integrated with various types of aiding sensors.

Abstract: A device for capturing an individual's breath as a keepsake includes a hollow blow-pipe insertable through an aperture through a neck fitted into an aperture of the vessel. After introducing one or more individual's breath into the vessel, the vessel is sealed, such as by using a plug removably attached to an end of the blow-pipe disposed within the vessel and configured to engage the neck as the blow-pipe is removed from the vessel and disengaged from the plug.

Abstract: A total amount of volatile organic compounds (VOCs) in a breath sample (101) is detected by oxidizing/burning (120) the VOCs to form CO2 and H2O, and the amounts of one or both of these compounds are measured (130). CO2 and H2O molecules in the breath sample (101) are removed (110) before the VOCs are converted (120) to CO2 and H2O. Because one VOC molecule contains multiple carbon and hydrogen atoms, the number of formed CO2 and H2O molecules will be substantially larger than the original number of VOC molecules, thereby improving the sensitivity of the detection.

Abstract: An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.

Abstract: A system for collecting an exhaled breath sample and exhaled breath aerosol from a subject includes a condensation chamber having an outerwall defining an interior space. The outer wall has an inlet port and an outlet port therethrough in fluid communication with the interior space. The inlet port is placeable in fluid communication with an exhaled breath sample of the subject. A condensation element is positioned within the condensation chamber interior space and has a shape tapering downwardly toward a bottom tip thereof. A condensation of fluid on the condensation element is enhanced through various elements. A collection area is positioned within the condensation chamber's interior space beneath the condensation element bottom tip. The collection area is for collecting condensate accumulating on an outer surface of the condensation element and dropping from the tip thereof.

Abstract: A method of diagnosing the health of an individual by collecting a breath sample from the individual and measuring the amount of each of a plurality of analytes in the sample. The amount of each analytes is measured by fitting a time response curve of a sample-evaluation fuel cell in which the fuel cell sample electrode is contacted with the sample with the analysis based on a function of standard time response curves for an equivalent fuel cell configuration obtained separately for each of the analytes on a fuel cell with equivalent construction as sample-evaluation fuel cell. Each of the plurality of analytes is generally indicative of an aspect of the individual's health. Suitable analytes include, for example, inorganic compounds as well as compositions that exhibit negative reduction reactions at least for a portion of the time response curve.

Abstract: An oxygen mask comprises an oxygen supply unit and an attachment unit which is to be attached to a periphery of a nose or a nose and a mouth of a patient. The attachment unit includes an opening which communicates with external air and which is formed at a position to which, when the oxygen mask is attached to the patient, at least one of the nose and the mouth of the patient is opposed.

Abstract: The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.

Abstract: A system for sampling exhaled breath and for supply of a gas, the system comprising: a gas delivery cannula comprising at least one nasal prong for insertion into a nostril, the nasal prong comprising a distal end; an exhaled breath sampling cannula for insertion into the nostril, the exhaled breath sampling cannula comprising a distal end; and a connector for coupling the gas delivery cannula to the exhaled breath sampling cannula, such that the distal end of the exhaled breath sampling cannula is disposed deeper in the nostril than the distal end of the nasal prong, to reduce dilution of sampled exhaled breath by delivered gas. The connected is configured to facilitate adjustability of an insertion depth of the exhaled breath sampling cannula into said nostril.

Abstract: A bite block includes: a first wall defining a hole into which a conduit pipe is to be inserted; a second wall surrounding the first wall to define a flow path with the first wall; and a sample port communicating with the flow path.

Abstract: There is provided herein a breath sampling device comprising a controller adapted to initiate a signal to trigger a valve functionally associated with a breath sampling tube upon said controller receiving a signal indicating a blockage in the breath sampling tube. The valve is adapted to facilitate an increase of pressure within the breath sampling tube between the blockage and a pump functionally associated with the breath sampling tube. There is further provided herein an airway adapter comprising a restrictor located in proximity to a connection point between the airway adapter and a breath sampling tube, wherein the restrictor may be adapted to reduce the flow rate of liquids entering the breath sampling tube.

Abstract: A breath condensing apparatus includes a mouthpiece, a condenser having an inlet coupled to the mouthpiece, a first container for collecting condensate communicating with an outlet of the condenser, and a second container for collecting residual, non-condensed exhaled breath coupled to the condenser. A method of condensing exhaled breath includes the features of receiving exhaled vapor into a condenser, condensing at least part of the exhaled vapor, collecting at least part of residual, non-condensed exhaled vapor, recirculating at least part of the collected residual vapor through the condenser, condensing at least part of the recirculated vapor, and collecting condensate.

Abstract: A pneumostoma assessment and treatment system includes methods and devices for aftercare of a pneumostoma. In particular, methods and devices are provided for standardized monitoring and assessment of pneumostoma patency thereby facilitating the establishment of standards-based protocols for pneumostoma management. Methods of standardized pneumostoma patency assessment includes the use of devices for raising alveolar pressure to a controlled repeatable pressure above ambient while analyzing gas flow through the pneumostoma. In response to an assessment the functionality of the pneumostoma, the tissues of the pneumostoma may be treated with a treatment device utilizing one or more different modalities to preserve or enhance the health and function of the pneumostoma.

Abstract: A congestion monitoring system includes a generally cylindrical, hollow form to channel a patient's breath, a flow restriction within the hollow form, and a pair of air ports. One of the air ports is located on the hollow form at a first side of the flow restriction, and the other air port is located on the hollow form at a second side of the flow restriction. The system also includes a coupling for connecting the pair of air ports to a pair of air lines, a sensor in communication with the air ports via the pair of air lines, and a monitor device. The monitor device converts a pressure signal from the air ports into a signal representative of a flow rate of the patient's breath through the hollow form.

Abstract: The present invention relates to a portable, personal breath tester device for testing the blood alcohol content of the user of the device. The breath tester comprises a circuit board, wherein a sensor, a liquid crystal display, and a processing unit are installed on and electrically connected to the circuit board. The processing unit receives a voltage signal from the sensor representing the blood alcohol content of the user and converts the voltage signal to a precise value that is displayed on the liquid crystal display.

Abstract: A sealing apparatus including an inlet for receiving a first breath sample from a user for fastening the sealing apparatus to an external device, the first breath sample including a plurality of organic compounds or molecules, a select combination of the plurality of organic compounds or molecules being used to create a unique breath profile; and a module for analyzing and storing the first breath sample as the unique breath profile; wherein the inlet further receives a second breath sample and compares the second breath sample with the first breath sample to determine whether access to the external device is permitted.

Abstract: A breath condensate sampler for use with a mechanical ventilator, the breath condensate sampler includes an airflow valve, a condensate formation tube, a condensate trap, and a condensate collection receptacle. The airflow valve directs air from the expiratory limb into the condensate formation tube wherein the condensate portion of exhaled gases are separated from the gaseous portion of the exhaled gases. A method of collecting a breath condensate sample is also herein disclosed.

Abstract: There is provided an airway tube for breath sampling, comprising a breath sampling port comprising two or more inlets adapted to sample breath from the airway tube. The inlets are connected to each other through a junction located outside of the air passageway of the airway tube.

Abstract: An endoscopic bite block comprising a tubular body having an upper outer surface and a lower outer surface; a front plate having an upper section and a lower section, said upper section being disposed outwardly relative to said lower section, to enable appropriate lip fitting; a teeth positioning region on at least one of said upper and lower outer surfaces; and a nasal gas channel selected from the group consisting of: a breath sampling prong and a gas delivery channel, wherein said teeth positioning region and the disposition of said sections of the front plate are configured to maintain said endoscopic bite block in a predetermined, upright position within a mouth of a subject, to enable a correct position of said nasal gas channel in relation to a nose of the subject.

Abstract: A breath condensate collector (10) comprising a chamber having a breath inlet port (14) and an outlet port (16); a sample collector, adapted to receive breath from the chamber outlet and having air exhaust means; cooling means (112) to promote in use condensation of vapour from breath entering the sample collector and where the sample collector comprises a partially lidded dish (110).

Abstract: A lung diagnosis apparatus for measuring the flow, the flow rate, the respiratory air density and the molar mass of a living organism, includes a respiration tube through which respiratory air flows. On the outer surface of the respiration tube, on mutually opposite sides thereof, there are mounted two tube nozzles, of which the longitudinal axis thereof, or the nozzle axis, extends in an inclined manner relative to the longitudinal axis of the respiration tube, or tube axis. In the two tube nozzles, either a first ultrasound transmitter or a first ultrasound receiver is fixed. An electronic module, which actuates the first ultrasound transmitter and the first ultrasound receiver, evaluates their signals. A third tube nozzle and a fourth tube nozzle are arranged on mutually opposite sides of the respiration tube. The longitudinal axes of the third tube nozzle and the fourth tube nozzle define cross-nozzle axes, and extend orthogonally to the tube axis.

Abstract: A collection device (10), such as a mask, for collecting constituents of interest present in an airstream exhaled by a subject The collection device comprises a support member (12) mountable external to the nose and/or mouth of the subject, and at least one collection region (13) mounted to the support member (12) for collecting at least some of said constituents. The constituents are collected in a manner that allows subsequent analysis of the constituents. When the support member (12) is mounted over the nose and/or mouth of the subject, at least some of the exhaled airstream passes through the at least one collection region (13).

Abstract: A filter assembly for use in sidestream gas sampling assembly. The filter assembly of the present invention includes a hydrophilic The filter further includes a hydrophobic member positioned downstream of the hydrophilic liner. The hydrophobic disk acts as a second line of defense against moisture reaching the sensing mechanism. member that is constructed from a porous material and is situated such that gas entering the filter assembly passes through at least a portion the hydrophilic member. In a further embodiment, the filter includes a hydrophobic member positioned downstream of the hydrophilic member. The hydrophobic member acts as a second line of defense against moisture reaching the sensing mechanism in the gas sampling assembly.

Abstract: There is provided a breath sampling tube including an inner conduit, wherein at least a portion of the inner conduit is non-cylindrical and adapted to store liquids. There is also provided a breath sampling system including a gas analyzer and a breath sampling tube may include an inner conduit, wherein at least a portion of the inner conduit is non-cylindrical and adapted to store liquids. Also provided is a method of breath sampling including channeling breath through a tube having an inner conduit, wherein at least a portion of the inner conduit is non-cylindrical and adapted to store liquids. There is further provided, a self-drying liquid reservoir for a breath sampling tube comprising a housing having a diameter larger than the diameter of the sampling tube; and a wick material essentially within the housing adapted to retain liquid, wherein the reservoir is adapted to permit gas flow through the housing.

Abstract: An exhalation collected in a breath bag capable of expanding and contracting is sucked into a gas inlet vessel 21 with a given volume (Va), and then the gas inlet vessel 21 is communicated by means of valve V2 with a cell 11 that is maintained at an atmospheric pressure by being pre-filled with a sample gas or reference gas. After the communication, the gas pressure is measured by a pressure sensor 16 attached to the cell 11. Whether the exhalation collected in the breath bag is below a given amount or not can be accurately judged.

Abstract: Aerosol collectors 10, 120 include pre-collection filters 100, 126, aerosol collection chambers 30, 130, and other exhaled breath conditioning and control features for providing not only accurate and efficient, but also reliable and reproducible aerosol collections that can be used in standardizations and can be compared in meaningful ways to other exhaled breath aerosol collections from the same test subject and from different test subjects. The aerosol collector 10 example includes electrostatic collection components 34, 40, and the aerosol collector 120 includes nucleating condensation components 168, 172 and vortex collection components 132, 138. Both include analyte extraction apparatus 50, 124.

Abstract: According to a preferred embodiment of the present invention there is provided a bite block assembly adapted for capnography and oxygen delivery to a subject, the bite block assembly including a first capnography passageway adapted for passage therethrough of exhaled breath from the subject to a capnograph and a second oxygen delivery passageway, separate from the first passageway, adapted for passage therethrough of oxygen from an oxygen source to the mouth of the subject.

Abstract: A method for determining whether a subject has Gram negative bacterial pneumonia based on the presence of lipopolysaccharide in exhaled breath condensate collected from the subject. The collection devices utilized to collect exhaled breath condensate from both spontaneously breathing and mechanically ventilated subjects and the devices utilized to determine whether lipopolysaccharide is present in the collected exhaled breath condensate.

Abstract: A mouthpiece with an eject mechanism is disclosed. The mouthpiece includes an eject mechanism adapted to conform to a testing device, such as a breath analysis device. The eject mechanism allows for hygienic removal of a used mouthpiece from the testing device. A guiding surface allows for alignment of the mouthpiece with the testing device.

Abstract: The invention concerns a method for controlling a respiratory gas monitor device, which typically comprises at least one respiratory gas analyzer, a gas sampling line, a gas pump for sucking sample(s) of respiratory gas from said gas sampling line, a power supply and a processing unit, and a pressure sensor pressure-connected to said gas sampling line and electrical-signal-connected to said processing unit. A minimum value and a maximum value in a signal from the patient are detected by said processing unit, and a difference between said minimum value and said maximum value is calculated, and is compared with a predetermined threshold value. If said calculated difference is below said threshold value said pump is switched off or kept non-operating by said processing unit, and if over said threshold value said pump is switched on or kept operating by said processing unit.

Abstract: A videorhinohygrometric measuring apparatus (1) for evaluating parameters associated to the expiratory flow outlet from the nostrils, comprising-a camera (4) for acquiring the dynamic image of the condensation that the flow generates on a suitable collecting surface (21) and a processor (5) for the acquired image, operatively connected to the camera (4) and apt to output at least one of the above-mentioned entities (FIG. 2).

Abstract: A breath collection apparatus is provided that includes a facemask to cover the nose and mouth of a patient to direct the breath into a collection bag or collection vial. A valve assembly containing a flexible valve member is provided between the facemask and the collection container to direct a breath sample to the collection container while permitting fresh air to enter the facemask upon inhalation. Between the valve assembly and the collection container is a collection container attachment fitting for engaging the valve assembly with the collection container. The collection container attachment fitting can be a two-piece fitting designed to accommodate a flexible bladder used to accumulate multiple breath samples for subsequent delivery to the collection container.