Abstract: Systems, devices, and methods are described for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions, including autism spectrum disorders (ASD) by analysis of eye tracking data generated from feedback received as a result of display of specific predetermined visual stimuli to a subject or patient. Subsequent to a calibration phase, a testing procedure is performed by presenting predetermined stimuli (e.g., videos) to a subject via a display device. Eye tracking data (from the subject moving his or her eyes in response to predetermined movies or other visual stimuli) are collected. During the data collection period, the system periodically presents targets to reflexively elicit the subject's gaze. These data are used to later verify accuracy. Analysis of the subject's viewing patterns during these stimuli is used for the assessment, screening, monitoring, or diagnosis of developmental or cognitive conditions such as ASD.

Abstract: Technology is described for providing a virtual spectator experience for a user of a personal A/V apparatus including a near-eye, augmented reality (AR) display. A position volume of an event object participating in an event in a first 3D coordinate system for a first location is received and mapped to a second position volume in a second 3D coordinate system at a second location remote from where the event is occurring. A display field of view of the near-eye AR display at the second location is determined, and real-time 3D virtual data representing the one or more event objects which are positioned within the display field of view are displayed in the near-eye AR display. A user may select a viewing position from which to view the event. Additionally, virtual data of a second user may be displayed at a position relative to a first user.

Abstract: A system and a method for monitoring change of intraocular pressure and a contact lens for sensing change of intraocular pressure are provided. The contact lens includes a first material layer and a first pattern. The center of the first material layer has an optical region, and the optical region corresponds to a cornea region of an eyeball. The first pattern is formed on the optical region. Furthermore, the contact lens may further include a second material layer and a second pattern. The second material layer is located on the first material layer. The second pattern is formed on the second material layer and overlaps with the first pattern to form a moire pattern.

Abstract: An apparatus and method of encoding eye movements and eye tracking data (DAT), represented as time and space parameters (t, x, y) obtained by an eye tracking device and assigned each to a viewpoint (A, B, C, D, E . . . ). Pairs of numbers (Z0,Z1; Z0,Z2; Z0,Z3 . . . ) are taken from the groups of numbers and are combined with each other to obtain for each combination a value (W) that indicates at least a spatial distance (S) between two viewpoints (E, C), wherein the obtained values (W) represent an encoding of the eye movement and eye tracking data (DAT). Preferably the values (W) are determined and stored in form of a first matrix (M) or array. The matrix is subjected to one or more operations (smooth filtering, anisotropic filtering, threshold filtering, anisotropic diffusion) such that the resulting matrix represents an encoding of fixations, saccades and smooth pursuit of a raw data scanpath.

Abstract: Here we present the first model that quantitatively predicts the apparent spatial position and shape of percepts elicited by retinal electrical stimulation in humans based on the known anatomy of the retina. This model successfully predicts both the shape of percepts elicited by single electrode stimulation and the shape and relative positions of percepts elicited by multiple electrode stimulation. Model fits to behavioral data show that sensitivity to electrical stimulation is not confined to the axon initial segment, but does fall off rapidly with the distance between stimulation and the initial segment. Using the model, it is possible to compensate, preferably with a look up table, to match percepts to a desired image.

Abstract: A method and an apparatus for marking electronic document are provided. An image sequence of a user is captured by an image capturing unit, and an eye tracking procedure, a nod detecting procedure and a blink detecting procedure are executed for analyzing the image sequence. A first position on the electronic document where a current sightline of the user falls when the user performs a first specific action is obtained, and a marking action is executed for marking the electronic document along with a movement trajectory of the user's eyes starting from the first position. A second position on the electronic document where the current sightline falls when the user performs a second specific action is obtained, and the marking action is finished at the second position.

Abstract: An ECU 30 includes a face position and face feature point detection unit 32 that detects the feature points of the face of the driver, a face pose estimation unit 33 that fits the feature points of the face detected by the face position and face feature point detection unit 32 to a 3D face model to estimate the direction of the face of the driver, an eyelid range setting unit 34 that sets an upper eyelid presence range and a lower eyelid presence range including the positions of the upper and lower eyelids on the basis of the pose of the face estimated by the face pose estimation unit 33, and an eyelid detection unit 35 that detects the positions of the upper and lower eyelids in the upper eyelid presence range and the lower eyelid presence range set by the eyelid range setting unit 34.

Abstract: A method for detecting fatigue is provided herein. The present invention includes the following steps: measuring a plurality of physiological feature data from a user in continuous time to generate a feature sequence; computing the rate of drop and/or calculating the difference of the rate of drop based on the feature sequence; and determining the fatigue level of the user by analyzing the rate of drop and the difference of the rate of drop. A fatigue detecting device is also disclosed here. The present invention can be utilized to effectively monitor the fatigue level of the user.

Abstract: The invention relates to a intra lens (1) comprising a posterior surface and an anterior surface, said posterior surface having a curvature which is optimized for providing a minimal spherical aberration, wherein said curvature is optimized using the posterior chamber depth of an eye in which the IOL is to be inserted.

Abstract: A system is provided for monitoring intraocular pressure, the system comprising: a sensor package configured to be disposed in the suprachoroidal space of a patient's eye; a pressure sensor; a wireless transceiver disposed within the sensor package and coupled to the pressure sensor; an external transceiver, the external receiver being wirelessly coupled to the wireless transceiver when the transceiver is disposed proximate to the patient's eye.

Abstract: A system and method for improving social and presentation skills of persons with a social communication disorder such as Autism. Social anxiety or a lack of confidence, the method including: rendering and displaying on a display device a presentation script for an oral presentation to be made by a user; monitoring eye movement of the user during the oral presentation to measure a user's pupil movement and/or a user's gaze direction; displaying an indicia on a separate display screen and/or an upper portion of the display device; periodically displaying within the presentation script a visual prompt to cue the user to look at the indicia; measuring eye movement using eye tracking software and/or an eye tracking device, at occurrence of the visual prompt; and evaluating whether the user made eye contact with the indicia when prompted.

Abstract: In general, in some embodiments, the disclosure provides a method that includes making a subjective refraction of a person to determine information about the person's vision, making a wavefront measurement of one or both of the person's eyes to determine information about the optical properties of one or both of the person's eyes (e.g., aberrations), calculating a prescription for the person based on the information about the person's vision and the information about the optical properties of one or both of the person's eyes, and outputting the prescription.

Abstract: A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same virtual reality portable device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

Abstract: A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol including optokinetic testing that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

Abstract: The present invention provides a stimulus presentation system which determines a mental state and changes presentation contents of a problem based on the determined mental state. The system determines the mental state by measuring gaze and cerebral function of a user, and changes presentation contents of a problem based on the determined mental state.

Abstract: A method and system are presented to address quantitative assessment of visual motor response in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display; (2) modulating the contrast of a predetermined section of the scene; (3) moving the predetermined section relative to the scene with the movement being tracked by the subject via at least one input device; (4) measuring a kinematic parameter of the tracked movement; (5) quantitatively refining the tracked movement; (6) determining the relationship between at least one of the scene and the quantitatively refined tracked movement; (7) adjusting the modulated contrast relative to the quantitatively refined tracked movement; (8) calculating a critical threshold parameter for the subject; and (9) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system are presented to address quantitative assessment of word recognition sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a plurality of letters and a background, to a subject on a display; (2) moving the plurality of letters relative to the scene; (3) receiving feedback from the subject via at least one; (4) quantitatively refining the received feedback; (5) modulating the saliency of the plurality of letters relative to accuracy of the quantitatively refined feedback; (6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method of visual cognitive training is performed at a device with a display. The method includes sequentially displaying a plurality of visual stimuli in a first region of a subject's field of view. While sequentially displaying the plurality of visual stimuli, the device moves the first region periodically along a predefined path within the subject's field of view. The device prompts the subject to respond to a task associated with the sequential display of the plurality of visual stimuli. The device receives a response to the task associated with the sequential display of the plurality of visual stimuli and records information corresponding to the subject's response to the task associated with the sequential display of the plurality of visual stimuli.

Abstract: In a first aspect, the present invention provides a method of measuring attention of a person comprising presenting one or more stimulus aimed at attracting attention of the person; and obtaining positions of the eyes of the person. The method further comprises detecting one or more eye fixations from the obtained positions of the eyes; and measuring the angle of convergence of the eyes over time from the obtained positions of the eyes during one or more of the detected eye fixations.

Abstract: A human body support, such as a chair, has a plurality of support segments that are arranged in an array. Each support segment has a protrusion elevation that is independently variable and controllable in its distance of protrusion elevation against the supported human body. A sensor is connected to a human body on the support and senses a human body parameter that can indicate the presence of drowsiness. A controller analyzes the sensed parameter to detect whether the sensed parameter is within a range indicating the presence of drowsiness. The controller applies a wave of varying segment protrusion elevation against the human body in response to the detection of drowsiness. The wave progresses in a direction from an inferior location on the human body toward a more superior location. Alternatively, a wave of electrical stimuli is applied by similarly positioned electrodes and causes periodic tightening and relaxing of proximate muscles.

Abstract: A method detects a biological condition and detects a change in the biological condition of a mammal. The device determines if the change in the biological condition exceeds a predetermined threshold and sends a signal based at least in part on the determination.

Abstract: A system includes a display, sensor, and a processor. The display is configured to provide a controlled light stimulus. The sensor has an electrode configured for coupling to tissue. The sensor is configured to generate an output signal corresponding to an electroretinogram based on light evoked activity associated with glutamatergic synaptic processing. The light evoked activity is in response to an image on the display. The processor is coupled to the sensor and is coupled to the display. The processor is configured to classify a neurological condition associated with the tissue. The classification is based on the output signal.

Abstract: Embodiments disclose systems and methods that aid in screening, diagnosis and/or monitoring of medical conditions. The design includes a system and method for accessing retinal images related to a patient, each retinal image including a plurality of pixels. For each of the retinal images, the system designates a first set of the plurality of pixels as active pixels including interesting retinal image regions and computes a first vector of numbers comprising pixel-level descriptors for each of the active pixels. The system computes a second vector of numbers for each of the retinal images and provides a second classification using supervised learning.

Abstract: A method of determining a corneal thickness and an apparatus for determining said is provided. The method comprises the following the steps: —illuminating a cornea by a plurality of stimulator point light sources, capturing an image of the cornea comprising reflected images of the stimulator point light sources, obtaining a model representing an anterior surface of the cornea, —constructing a second model representing a posterior surface of the cornea from the image by ray-tracing the reflected images of the stimulator point light sources towards the model representing the anterior surface of the cornea, determining the corneal thickness from the model representing the anterior surface and the second model representing the posterior surface.

Abstract: A method and system are presented to address quantitative assessment of social cues sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a single facial expressions and a background, to a subject on a display; (2) adjusting the facial expression on the scene; (3) receiving feedback from the subject via at least one input device; (4) quantitatively refining the received feedback; (5) modulating the adjusted facial expression relative to the accuracy of the quantitatively refined feedback; (6) transforming the modulated facial expression; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A system and method is provided for calibrating and normalizing eye data of one or more subjects prior to and/or during emotional testing of the subjects. In particular, initially performing one or more calibration or normalization operations prior to an emotional test of a subject may result in accurate evaluations of emotional responses based on measurements of eye data. Additionally, further calibration or normalization performed during the emotional test may be used to refine the initial calibration or normalization, further increasing the accuracy of the evaluated emotional responses.

Abstract: A method and system are presented to address quantitative assessment of spatial sequence memory in a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of elements and a background; (2) modulating the saliency of a predetermined section of said scene (3) receiving feedback from the subject via at least one input device; (4) modifying the saliency of the predetermined section; (5) adjusting a functional assessment parameter relative to the scene; (6) moving the predetermined section relative to the scene; (7) receiving refined feedback from the subject via the input device; (8) quantitatively refining the refined feedback; (9) calculating a critical threshold parameter for the subject; and (10) recording the critical threshold parameter onto a tangible computer readable medium.

Abstract: Cognitive deficits involving attention, sequential processing, reading, speed of processing, and navigation may be diagnosed and remediated in a subject by respectively measuring and improving contrast sensitivity for motion discrimination of the subject. A background may be displayed with a contrast and temporal frequency and either single, or multiple, higher spatial frequencies that may repeat over a wider area than the individual frequency components. A test window may be superimposed over the background, and includes a test pattern with a contrast and a spatial frequency and a temporal frequency. The subject may provide a signal indicative of the direction the subject believes the test pattern moved. In response to this signal, the contrast of the test pattern, the spatial frequency of the background, the spatial frequency of the test pattern, or the temporal frequency may be modified, either by increasing or decreasing its respective value.

Abstract: A method and system are presented to address quantitative assessment of facial emotion nulling of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a single facial expressions and a background, to a subject on a display; (2) adjusting the facial expression on the scene; (3) receiving feedback from the subject via at least one input device; (4) quantitatively refining the received feedback; (5) modulating the adjusted facial expression relative to the accuracy of the quantitatively refined feedback; (6) transforming the modulated facial expression; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system are presented to address quantitative assessment of verbal memory of a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of symbols and a background; (2) moving the plurality of symbols relative to the scene, the movement being tracked by the subject via at least one input device; (3) adjusting the saliency of the plurality of symbols relative to the tracked movement; (4) increasing the number of said plurality of symbols; (5) receiving feedback from the subject via said input device; (6) quantitatively refining the received feedback; (7) modulating the movement of the plurality of symbols relative to the accuracy of the quantitatively refined feedback; (8) calculating a critical threshold parameter; and (9) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system are presented to address quantitative assessment of word identification latency of a subject, where the method comprises the steps of: (1) presenting at least one scene, comprising a plurality of letters and a background, to a subject on a display; (2) moving the plurality of letters relative to the scene; (3) receiving feedback from the subject via the input device; (4) quantitatively refining the received feedback; (5) modulating the movement of plurality of letters relative to accuracy of the quantitatively refined feedback; ((6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system are presented to address quantitative assessment of word recognition sensitivity of a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, the scene comprising a plurality of letters and a background; (2) distorting the scene; (3) moving plurality of letters relative to the scene, the movement being tracked by the subject via at least one input device; (4) receiving feedback from the subject via the input device; (5) quantitatively refining the received feedback; (6) modulating the movement of plurality of letters relative to accuracy of the received feedback; (7) calculating a critical threshold parameter; and (8) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system is presented to address quantitative assessment of functional impairment in a subject, comprising: presenting a plurality of tests to a subject on a display, the tests comprising a series of scenes, the scene comprising at least one stimulus, wherein the scene may be associated with visual, auditory, and tactile stimulus arrays; modulating at least one spatial characteristic of at least one stimulus; receiving feedback from the subject via at least one input device; quantitatively refining the scene relative to the received feedback; calculating the relationship between at least one of the scene, the stimulus, and the quantitatively refined scene; adjusting the scene relative to the calculated relationship; determining equilibrated scene parameter of the subject; recording the equilibrated scene parameter onto a tangible computer readable medium; generating at least one diagnosis to the functional impairment associated with the equilibrated scene parameter; recommending treatment to the su

Abstract: A method and system are presented to address quantitative assessment of social interactions nulling testing of a subject, where the method comprises the steps of: (1) presenting at least one scene to the subject on a display, the scene comprising a plurality of body images and a background; (2) receiving feedback from the subject via at least one input device; (3) quantitatively refining the received feedback; (4) modulating the adjusted body image relative to the accuracy of the received feedback; (5) calculating a critical threshold parameter for the subject; (6) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method and system are presented to address quantitative assessment of letter identification latency of a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, the scene comprising a plurality of letters and a background; (2) moving the plurality of letters relative to the scene, the movement being tracked by the subject via at least one input device; (3) receiving feedback from the subject via the input device; (4) quantitatively refining the received feedback; (5) modulating the movement of plurality of letters relative to accuracy of the received feedback; (6) calculating a critical threshold parameter; and (7) recording a critical threshold parameter onto a tangible computer readable medium.

Abstract: A method of testing a subject for impairment includes presenting the subject with a display of a smoothly moving object, repeatedly moving over a tracking path and, while presenting the display to the subject, measuring the subject's right eye positions and measuring the subject's left eye positions. The method further includes generating a disconjugacy metric by comparing the measured right eye positions with the measured left eye positions, comparing the disconjugacy metric with a predetermined baseline to determine whether the disconjugacy metric is indicative of an impairment, and generating a report based on the disconjugacy metric.

Abstract: Provided herein are methods of evaluating efficacy of a treatment in a subject having eye inflammation (e.g., a subject having dry eye syndrome) and selecting a subject for participation in a clinical study. Also provided are methods of treating a subject having eye inflammation (e.g., a subject having dry eye syndrome).

Abstract: Minor traumatic brain injury is detected by operating (a) an image generator for presenting a visual stimulus having a predetermined movement across a visual field of a subject and (b) a sensor device for monitoring fast eye movement of the subject while the subject views the stimulus. The sensor device generates a signal encoding the subject's eye position. A computer or microprocessor operatively connected to the sensor device is configured for determining a magnitude for the fast eye velocity component.

Abstract: A method and apparatus are presented to address quantitative assessment of visual form discrimination in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, said scene comprising a plurality of elements and a background; (2) distorting at least one geometric characteristic of at least one; (3) modulating the contrast level of the predetermined section of the scene; (4) moving the predetermined section relative to the scene, the movement being tracked by said subject via at least one input device; (5) receiving feedback from the subject via the input device; (6) quantitatively refining the received feedback relative to the scene; (7) adjusting at least one distorted geometric characteristic relative to the accuracy of the quantitatively refined feedback; (8) calculating the critical threshold parameter for the subject; and (9) recording the critical threshold parameter onto a tangible computer readable medium.

Abstract: Systems and methods for determining a volume of the posterior segment of an eye during a fluid-to-gas exchange are described. The determined volume of the posterior segment may be used to determine the volume of pure tamponade gas to be introduced into the posterior segment resulting in a desired tamponade gas to other gas (e.g., air) ratio, such as during an ophthalmic surgical procedure. Particularly, the systems and methods may provide for improved gas utilization, less waste, and reduced surgery time, for example, by accurately measuring the volume of the posterior segment of the eye and only using the amount of pure gas required to produce the desired ratio. Further, in some implementations, mixing of a tamponade gas is accomplished intrinsically within the posterior segment of the eye, thereby avoiding manual mixing and reducing surgery time.

Abstract: A physiological sensor apparatus comprises a physiological sensor, a headband and an eye mask. In one example, the physiological sensor includes a plurality of electroencephalography (EEG) electrodes that are used to sense a signal indicative of a sleep stage (e.g., REM sleep or non-REM sleep) of a user. Each end of the headband attaches to respective ends of the sensor and eye mask such that when the sensor is disposed on the forehead of the user, the eye mask shields the eyes of the user from visible light. The diameter of the headband is adjustable by the user to secure the sensor to the forehead of the user. The sensor accurately determines the sleep stages of the user over a period of sleep of the user because the adjustable headband and eye mask prevent the electrodes from being displaced from the forehead of the user during the period of sleep.

Abstract: A method and apparatus for monitoring optic function is provided. The apparatus and method relies on two principle modes of measuring the function of the optic nerve, namely, monitoring VEPs for neural function, and monitoring at least one additional parameter of optic function such as intraocular pressure, blood flow or location of the eye to provide a multi-variable optic function monitor. The method and apparatus is proposed for the use to diagnose and potentially prevent the incidence of POVL and anaesthesia awareness in patients during medical procedures.

Abstract: Apparatus (1) for use in a method for psychiatric evaluation comprises: memory means (4) for holding a store of pre-selected images; display means (12) for displaying a succession of said images to a patient; eye tracking means (6) for tracking eye movement of a patient; recording means (8) for recording eye movement data corresponding to a patient's eye movement in response to the display of said succession of images; control means (2) for controlling the display means to display the images to the patient, and for controlling the recording means to record said eye movement data and displayed image data; and evaluation means (10) for evaluating said eye movement data and displayed image data for use in identifying a psychiatric profile of the patient.

Abstract: A system for creating an eye-movement record that is useful for diagnosing balance disorders of a patient includes a head-mounted unit having an indicator which generates head position signals. Also included is a computer/controller for progressing the patient through a sequence of predetermined head orientations. An imaging unit in the head-mounted unit is used to create an eye-movement record for each head orientation, and the records are then archived in a recorder. With instructions from the patient, a de-identified eye-movement record can be sent to selected regional specialists for further evaluation and possible treatment.

Abstract: An objective non-invasive method for quantifying itch comprising the steps of presenting a visual stimulus to a subject, wherein the visual stimulus comprises focusing the subject on itch; collecting psychophysiological data from subject while presenting the visual stimulus; using the psychophysiological data to objectively assess the therapeutic value of a treatment or a product.

Abstract: A system for monitoring drug taking compliance utilizes cognitive testing after the scheduled administration of the medicine to determine compliance by measuring cognitive function.

Abstract: Minor traumatic brain injury is detected by operating (a) an image generator for presenting a visual stimulus having a predetermined movement across a visual field of a subject and (b) a sensor device for monitoring fast eye movement of the subject while the subject views the stimulus. The sensor device generates a signal encoding the subject's eye position. A computer or microprocessor operatively connected to the sensor device is configured for determining a parametric value for the fast eye velocity component.

Abstract: A system and method for determining a subject's attentional response to a stimulus. The method includes measuring microsaccadic eye movement dynamics of the subject, detecting whether a microsaccadic signature (a suppression in microsaccadic rate) is present in the measured microsaccadic eye movement relative to a time of the stimulus, and correlating the subject's attentional response to the stimulus based on the detection. The method further includes determining that the stimulus was sensed if the microsaccadic signature is present and determining that the stimulus was not sensed if the microsaccadic signature is absent.

Abstract: A method is provided of systematically evaluating and treating dynamic autonomic dysregulation in a subject. The method includes having the subject sequentially assume a plurality of distinct postures that may include, for example, walking, standing, sitting or supine. In each posture of the subject, the subject is subjected to sensory stimulation while measuring at least one autonomic physiological response of the subject. The autonomic physiological response may include, for example, oxygen saturation, heart rate, pupillary response, blood pressure, sweat production, pseudomotor activity or respiration. The physiological responses in each of the distinct postures are evaluated to identify a posture wherein the subject exhibits a least amount of dysfunction.

Abstract: Typical neurological examinations focus on qualitative and subjective assessments, including obtaining a patient history, assessing the patient's cognitive status, motor and sensory skills, and cranial nerve functionality. A quantitative assessment of neurological condition includes recording a subject performing a visuomotor task and processing the performance data to determine a level of complexity in the task activity and determine a complexity index. For a sample healthy population, a baseline level of complexity and baseline complexity index can be determined. A patient's complexity index can be compared to this baseline complexity index as an indication of disease or disability. A baseline complexity index can be determined for a patient at part of a health maintenance examination and used as the baseline complexity to detect disease or disability in the future based on lower complexity index values in future examinations.