Abstract: System for monitoring at least one biomechanical ophthalmic parameter, the system comprising a measuring device (1) adapted to be placed on or implanted into an eye of a patient for measuring said at least one biomechanical ophthalmic parameter of said eye, a recording device (6) for obtaining from said measuring device (1) measurement data representative of the instant value of said at least one biomechanical ophthalmic parameter of said eye, wherein said recording device is adapted to obtain said measurement data at a predetermined frequency equal to or greater than twice the variation frequency of said at least one biomechanical ophthalmic parameter.

Abstract: A method implemented in a computing system is provided to determine an individual's level of impairment through a comparison of an individual's pre-impairment base-line score, and an individual's post-impairment score through the system's administration of a plurality of tasks to completed by the individual, and to be calculated and stored by the system.

Abstract: A non-invasive method for determining and characterizing the presence of damage or abnormalities resulting from or concomitant with systemic hypertension in subject. This method is comprised of the acquisition of ocular image(s) and subsequent evaluation, classification and/or interpretation of these image(s). The ocular image(s) may be acquired by photography. Evaluation, classification, and/or interpretation may be automated or involve the active participation of a human. The ocular images may be classified into either a normal or clinical group or compared to an algorithm of hypertensive symptoms. The ocular images may, additionally, be processed and have the pertinent characteristics extracted to make the classification more exact.

Abstract: A kiosk may include a main body with a front surface and a seat assembly located near the main body adjacent to the front surface of the main body.

Abstract: A system and method is provided for calibrating and normalizing eye data of one or more subjects prior to and/or during emotional testing of the subjects. In particular, initially performing one or more calibration or normalization operations prior to an emotional test of a subject may result in accurate evaluations of emotional responses based on measurements of eye data. Additionally, further calibration or normalization performed during the emotional test may be used to refine the initial calibration or normalization, further increasing the accuracy of the evaluated emotional responses.

Abstract: Methods for assessing cognitive and linguistic abilities by tracking and recording the eye movements of a patient in response to predetermined verbal and visual stimuli. The methods incorporate conventional eye-tracking technology to acquire eye-fixation location and duration measures for testing linguistic comprehension, working memory, attention allocation, and the effect of semantic associative priming. Visual stimuli presented in the methods are carefully designed to reduce visually distracting features. Verbal stimuli are carefully designed to control for numerous linguistic features.

Abstract: A system and method are provided whereby periodic measurements of autonomic reflex times of individuals are used as an early-warning indication that an undesirable physical condition, such as an undesirable blood-chemistry condition, may exist. This method correlates measurements of the reaction times of specific autonomic reflexes to more-definitive measurements for the medical condition being monitored for this early-warning assessment.

Abstract: A portable virtual reality device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same virtual reality portable device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

Abstract: A method for predicting whether a patient is afflicted by a vestibular disorder includes assaying vestibular noise; identifying a characteristic of the vestibular noise; and at least in part on the basis of the characteristic of the vestibular noise, providing information for predicting that a patient has a vestibular disorder.

Abstract: The present invention relates to a test device which is designed for measuring the caution and intuitional capability of the individuals, by providing the individual to make an estimate about the position of the stimulus (U1) at a certain time after the visual stimulus (U1) disappears from the screen (20) and after the stimulus continues the movement thereof in an invisible manner.

Abstract: Described herein are stress detection systems and methods of using such systems.

Abstract: A medical device includes an array of electrodes, configured for implantation in contact with tissue in an eye of a living subject. Driver circuitry is configured to drive the electrodes in an alternating pattern, such that different groups of the electrodes are driven to stimulate the tissue during different, predetermined respective time periods. A power sensor, may be coupled to deactivate a first group of the electrodes when the available electrical power drops below a predetermined threshold, while a second group of the electrodes remains active. Other embodiments are also described.

Abstract: A direct visualization (DV) system and methods for measuring one or more anatomical features of the eye, including a depth of the iridocorneal angle of the eye. The DV system can include a wire extending distally from a handle with the wire having one or more indicators for measuring anatomical features of the eye. The DV system can be deployed into the eye and used with minimal trauma to ocular tissues. Furthermore, the DV system can be used independently or alongside other ocular instruments, such as instruments having indicators corresponding to the DV system for correctly implanting ocular implants without the use of a gonio lens.

Abstract: The present invention provides methods and systems to periodically monitor the emotional state of a subject comprising the steps of: exposing the subject to a plurality of stimuli during a session; acquiring objective data from a plurality of monitoring sensors, wherein at least one sensor measures a physiological parameter; transferring the data to a database; and processing the data to extract objective information about the emotional state of the subject.

Abstract: An aspect of the present invention is a method for determining whether a Luciferian can be rehabilitated. The method includes stimulating the Luciferian with a first stimulus and recording a first physiological response by the Luciferian to said first stimulus. The method includes determining, from the first physiological response, a first polarity of the Luciferian's response to the first stimulus. The method includes stimulating the Luciferian with a second stimulus and recording a second physiological response by the Luciferian to said second stimulus. Further, the method includes determining, from the second physiological response, a second polarity of the Luciferian's response to the second stimulus. The method includes comparing the first polarity to the second polarity to determine whether the second polarity has a greater value than the first polarity; and determining, from said comparing of first polarity and second polarity, whether the Luciferian can be rehabilitated.

Abstract: Methods and systems for modifying or enhancing vision are described. In exemplary embodiments, neural or neuromuscular activity is analyzed to determine a focus or other quality of a visual input, and the focus or quality information used as a basis for controlling an adjustable lens system or optical system.

Abstract: A method is presented to address quantitative assessment of visual motion discrimination in a subject, where the method comprises the steps of: (1) presenting a scene, comprising a plurality of elements and a background, to a subject on a display; (2) moving a plurality of elements relative to the scene; (3) receiving feedback from the subject; (4) quantitatively refining the feedback; (5) modulating the movement relative to accuracy of the received feedback; (6) monitoring the response error; (7) calculating a critical threshold parameter for the subject; and (8) recording a critical threshold parameter onto a tangible computer readable medium. An apparatus for quantitative assessment of visual motion discrimination of a subject comprising a display device, an input device, a control device, and a tangible computer readable medium. In its simplest sense, a quantitative assessment profile of visual motion discrimination by psychophysical responses is generated on a tangible computer readable medium.

Abstract: A system for measuring the size of a capsular bag of an eye of a subject includes a size indicator and a sizing gauge. The size indicator is configured for insertion into a capsular bag and includes a peripheral portion and a pair of arms. The peripheral portion is configured to engage the capsular bag. Each of the arms has a proximal end and a distal end, the arms being joined to one another at the proximal ends. The peripheral portion is joined to the distal ends of the arms. The arms form an angle that depends on a size of the capsular bag into which the size indicator is placed. The sizing gauge has a body having a front surface, along with first and second features disposed along or behind the front surface. The features are configured to correspond to an angle that is within a predetermined range of angles of the arms of the size indicator when the size indicator is placed within a capsular bag.

Abstract: An information acquiring method configured to acquire brain activity information from biological subjects presented a sensory stimulus, in which the brain activity information is acquired by measuring the brain activity in at least one region of the brain areas of the biological subjects including the visual cortices of the cerebral cortex, the auditory cortices of the cerebral cortex, and the vestibular cortices of the cerebral cortex; while the stimulus which changes over time is presented to the brain areas by the stimulus presenting unit before and after the sensory stimulus is presented to the brain areas.

Abstract: A measuring method for synchronizing bio-signals with stimulations is capable of enhancing utility by using wireless synchronization signal transmission instead of conventional wired synchronization signal transmission and by using a signal processing approach to compensate a delay time in the wireless transmission to obtain a synchronous result. Thereby a stimulus signal corresponds to a biological response signal precisely in order to correctly generate integrated synchronization data of a stimulus organism.

Abstract: The invention relates to an ophthalmological analysis method for measuring an intraocular pressure in an eye with an analysis system consisting of an actuating device, wherein the actuating device causes a puff of air to be applied to the eye in such manner that the cornea is deformed, an observation system with which the deformation of the cornea is observed and recorded, wherein sectional images of the cornea when it is deformed and not deformed are created with the observation device, and an analysis device with which the intraocular pressure is derived from the sectional images of the cornea, wherein a structural characteristic and/or material characteristic of the cornea is derived from the sectional images of the cornea in the analysis device, wherein a stress of the cornea is derived as a structural characteristic and/or material characteristic, wherein stresses in the corneal material are rendered visible.

Abstract: A system for quantifying and mapping visual salience to a visual stimulus, including a processor, software for receiving data indicative of a group of individual's ocular responses to a visual stimulus, software for determining a distribution of visual resources at each of at least two times for each of at least a portion of the individuals. The system further including software for determining and quantifying a group distribution of visual resources at each of the at least two times and software for generating a display of the group's distribution of visual resources to the visual stimulus.

Abstract: The invention relates to an ophthalmological analysis method for measuring an intraocular pressure in an eye with an analysis system consisting of an actuating device with which a cornea of the eye is deformed in contactless manner, wherein the actuating device causes a puff of air to be applied to the eye in such manner that the cornea is deformed, an observation system with which the deformation of the cornea is observed and recorded, wherein sectional images of the cornea when it is deformed and not deformed are created with the observation device, and an analysis device with which the intraocular pressure is derived from the sectional images of the cornea, wherein a material characteristic of the cornea is derived from the sectional images of the cornea in the analysis device, wherein a stiffness of the cornea is derived as a material characteristic.

Abstract: The invention relates to an opthalmological analysis method for measuring an intraocular pressure in an eye with an analysis system consisting of an actuating device, wherein the actuating device causes a puff of air to be applied to the eye in such manner that the cornea is deformed, an observation system with which the deformation of the cornea is observed and recorded, wherein sectional images of the cornea when it is deformed and not deformed are created with the observation device, and an analysis device with which the intraocular pressure is derived from the sectional images of the cornea, wherein a material characteristic of the cornea is derived from the sectional images of the cornea in the analysis device, wherein a diameter d1 of a first applanation area of the cornea and a diameter dn of a deformation area of the cornea is derived as a material characteristic.

Abstract: An apparatus, system and method for performing a health correlation assessment based upon results an eye contrast sensitivity measurement test of a person. The health correlation assessment yields a predictive and probabilistic measure of the likelihood of the person appropriately assigned to a particular clinical health classification. Such an eye contrast sensitivity measurement can be used to identify people who are likely to be within a pre-Alzheimer's disease state or within Alzheimer's disease state of health and identify those who should seek further clinical and/or other types of testing to ascertain their actual health status and to determine an appropriate course of medical treatment.

Abstract: Devices and methods are disclosed that treat a medical condition, such as migraine headache, by electrically stimulating a nerve noninvasively, which may be a vagus nerve situated within a patient's neck. Preferred embodiments allow a patient to self-treat his or her condition. Disclosed methods assure that the device is being positioned correctly on the neck and that the amplitude and other parameters of the stimulation actually stimulate the vagus nerve with a therapeutic waveform. Those methods comprise measuring properties of the patient's larynx, pupil diameters, blood flow within an eye, electrodermal activity and/or heart rate variability.

Abstract: Modular user-exchangeable accessory for bio-signal controlled mechanism. In some embodiments, a biosensor and a feedback mechanism is disclosed. In some embodiments, a modular user-exchangeable accessory for bio-signal controlled mechanism includes detecting bio-signal using a bio-sensor; and sending a control signal to a modular user-exchangeable accessory for bio-signal controlled mechanism. In some embodiments, the biosensor is connected to a headset, wherein the modular user-exchangeable accessory is attachable to the headset. In some embodiments, the modular user-exchangeable accessory is shaped to resemble an animal ear.

Abstract: The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.

Abstract: User interfaces facilitate user interaction with virtual representations of anatomical structures that are displayed on computing systems. The user interfaces demonstrably reflect relative impacts on the anatomical structures based on corresponding conditions and treatments.

Abstract: The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual patient. By recording neural response to a predetermined input stimulus, one can alter that input stimulus to the needs of an individual patient. A minimum input stimulus is applied to a patient, followed by recording neural response in the vicinity of the input stimulus. By alternating stimulation and recording at gradually increasing levels, one can determine the minimum input that creates a neural response, thereby identifying the threshold stimulation level. One can further determine a maximum level by increasing stimulus until a predetermined maximum neural response is obtained.

Abstract: A method is presented to address quantitative assessment of spatial distractor tasks in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, said scene comprising a plurality of elements and a background; (2) modulating the saliency of a predetermined section of the scene; (3) receiving feedback from the subject; (4) superimposing an additional cue onto the scene; (5) generating a shift in attention of the subject; (6) receiving refined feedback from the subject; (7) quantitatively refining the refined feedback; (8) adjusting the motion associated with the scene relative to accuracy of the refined feedback; and (9) calculating a critical threshold parameter for the subject; and (10) recording the critical threshold parameter onto a tangible computer readable medium. An apparatus for quantitative assessment of spatial distractor tasks of a subject comprising a display device, an input device, a control device, and a tangible computer readable medium.

Abstract: A system and method for processing brain signals in a BCI system. The method of processing brain signals in a BCI system includes the steps of processing the brain signals for control state detection to determine if a subject intends to use the BCI system; and processing the brain signals for command recognition if the control state detection method determines that the subject intends to use the BCI system.

Abstract: A visual stimulation method and system for the field of electrophysiology of vision to obtain the suppression of the recording artifacts due to the luminance transients of the LCD monitors during the inversion of a main stimulation pattern (17) composed of a plurality of geometric elements, each of which is represented by a pair of complementary micropatterns (21, 22) and where the micropattern of each pair alternate between them in a synchronised manner with the frame rate.

Abstract: Provided are a device, system, and method for treating a patient having posttraumatic stress disorder (PTSD) or other such psychiatric disorder. An event being recounted by the patient is recorded and a sensory environment of the patient is controlled so as to administer exposure therapy to the patient. Patient mental state may be monitored during administration of the exposure therapy to the patient, and the exposure therapy may be varied in correspondence to the monitored mental state of the patient. In one embodiment, hierarchy assembly means creates a treatment hierarchy based on input from the patient, and hierarchy navigation means navigates within the treatment hierarchy in response to the mental state of the patient.

Abstract: An eye opening detection system that includes an imaging mechanism that captures an image of the face of a detected subject, an edge extraction mechanism that extracts the edge of the image captured, and an upper and lower eyelid detection mechanism that detects the upper and lower eyelids of the detected subject according to the edge extracted, and that detects the eye opening of the detected subject with reference to a detected distance between the upper and lower eyelids. The upper and lower eyelid detection detects the upper eyelid and detects the lower eyelid with reference to the upper eyelid detected.

Abstract: Systems and methods for diagnosing and treating psychiatric disorders are provided. For example, in one embodiment, the systems and methods generally include: (a) presenting an emotional conflict task to a patient; (b) receiving an input from the patient in response to the emotional conflict task; (c) assessing the patient's response to the emotional conflict task; and (d) modifying the emotional conflict task based on the patient's response. Such systems and methods may also be employed in a computerized training system for treating a patient with, or at risk of, a psychiatric disorder by training the patient's implicit emotional regulation.

Abstract: A contact lens shaped measuring device (1) includes sensor (3) having a protrusion (14) towards the cornea (22). The measuring device (1) is flexible to a degree that it is flattened by a closing eye lid and the protrusion creates an indentation of the cornea. The occurring force on the protrusion is measured by the sensor. Applying a constant lid acceleration/deceleration model to the movement of the lid and a mechanical model to the cornea, the tension of the cornea is determined and deduced from the force measured with the lid closed, yielding the true intraocular pressure. In an alternative, the protrusion is characterized by a discontinuity in its shape, or the sensor is subdivided, each subsensor being characterized by a protrusion of different shape. With the values obtained as extrema and at the discontinuity or with different protrusions, the cornea tension can be obtained by a (linear) extrapolation.

Abstract: One embodiment is directed to a patient interface system for ophthalmic intervention on an eye of a patient, comprising: a housing; an optical lens coupled to the housing and having a focal axis; a eye surface engagement assembly coupled to the housing and comprising an inner seal having an inner seal diameter and being configured to circumferentially engage the eye, an outer seal having an outer seal diameter and being configured to circumferentially engage the eye, and a tissue migration bolster structure configured to be positioned circumferentially between the inner and outer circumferential seals and to prevent migration of tissue of the eye toward the eye surface engagement assembly when a vacuum load is applied within the assembly to cause vacuum engagement of the inner and outer seals against the eye.

Abstract: Provided is a sensitivity evaluation system for estimating sensitivity of a subject from bio-information with high accuracy, including: an acquisition unit to acquire as biological data, a reaction of a sympathetic nervous system and a reaction of a parasympathetic nervous system; a biological data analysis unit to judge from the obtained biological data, a candidate group of sensitivity factors that the subject has; a positive/negative analysis unit to judge from information obtained from the subject, whether an inner state of the subject is pleasant or unpleasant; and a comprehensive evaluation unit to integrat analysis results of the biological data analysis unit and the positive/negative analysis unit to estimate the sensitivity comprehensively.

Abstract: An eye gaze tracking apparatus (100) includes: an electro-oculogram measuring unit that outputs an electro-oculogram original signal; a calibration index presenting unit (103) that presents a calibration index to a user; a saccade detection unit (104) that outputs an electro-oculogram change amount that is an amount of change in an electro-oculogram before or after a saccadic movement which is measured when a gaze-path position of the user moves to the calibration index; a calibration parameter calculating unit (105) that calculates a calibration parameter based on a position of the calibration index and an electro-oculogram change amount; and a calibration unit (101) that detects the gaze-path direction of the user from the electro-oculogram original signal.

Abstract: A method for measuring an upper limb reaching capability of a user with an impaired limb is provided. Each upper limb is placed at a default position on a horizontal surface. A target is displayed from among a plurality of targets on the horizontal surface. One of the limbs reaches for the target. Limb choice, position information and elapsed time are sensed and recorded. The reaching limb is retracted to the default position. The displaying step through the retracting step are repeated for each of the plurality of targets, wherein each of the plurality of targets is spaced apart.

Abstract: An implantable intraocular physiological sensor for measuring intraocular pressure, glucose concentration in the aqueous humor, and other physiological characteristics. The implantable intraocular physiological sensor may be at least partially powered by a fuel cell, such as an electrochemical glucose fuel cell. The implantable intraocular physiological sensor may wirelessly transmit measurements to an external device. In addition, the implantable intraocular physiological sensor may incorporate aqueous drainage and/or drug delivery features.

Abstract: The present invention provides methods and systems for assessing cognitive function by comparing a subject's eye movements within and across distinct classes of images.

Abstract: A system for quantifying and mapping visual salience to a visual stimulus, including a processor, software for receiving data indicative of a group of individual's ocular responses to a visual stimulus, software for determining a distribution of visual resources at each of at least two times for each of at least a portion of the individuals. The system further including software for determining and quantifying a group distribution of visual resources at each of the at least two times and software for generating a display of the group's distribution of visual resources to the visual stimulus.

Abstract: In systems and methods for generating cross-linking activity in an eye, a feedback system monitors a biomechanical strength of the eye in response to the photoactivation of a cross-linking agent applied to an eye. The feedback system includes a perturbation system that applies a force to the eye and a characterization system that determines an effect of the force on the eye. The effect of the force provides an indicator of the biomechanical strength of the eye. The characterization system determines the effect of the force on the eye by measuring an amount of deformation caused by the force or a rate of recovery from the deformation.

Abstract: A method includes directing toward a portion of a subject's body a first pulse of electromagnetic energy. While the portion is in a functional state due to the first pulse, a second pulse is directed toward the portion. At a second-pulse time, reflected energy due to the second pulse is detected. While the portion is in a functional state due to the first and second pulses, a third pulse is directed toward the portion. At a third-pulse time, energy of the third pulse, reflected from the portion, is detected. In response to detecting the pulses at the second-pulse time and the third-pulse time, a characteristic of the portion is quantified resulting from (a) the functional state due to the first pulse and (b) the functional state due to the first and second pulses. A clinical state of the subject is identified. Other embodiments are described.

Abstract: Various embodiments of a device for performing a gaze field sobriety test are disclosed. The device includes a housing. A light source is affixed in or on the housing. The light source generates light during at least a portion of the gaze field sobriety test. A speaker positioned in or on the housing generates sounds during at least a portion of the gaze field sobriety test. A power source is coupled to the speaker and the light source. An input is positioned on the housing. The input is selectable by a test administrator to initiate an audible sound through the speaker at a predetermined time interval during at least a portion of the gaze field sobriety test. The audible sound provides an indication to the test administrator during the gaze field sobriety test to assist in proper performance of the gaze field sobriety test.

Abstract: An embodiment of the invention is directed to a method for the real time monitoring and measurement of sleep quality of a subject comprising the steps of; obtaining information from the subject using sensory signals; analyzing the information contained within the signals using signal processing and artificial intelligence; and using the analyzed information to create a protocol to improve the sleep quality of the subject. Another embodiment of the invention is directed to a system for real time monitoring and measurement of sleep quality of a subject comprising: a means for obtaining sensory information from the subject; a means for transmitting the sensory information; a means for analyzing the sensory information; and a means for creating a protocol to improve the sleep quality of the subject.

Abstract: A detector located on a positioning tray has a plurality of colored caps placed by a subject being tested. Each cap has a unique resonant circuit which is selectively energized to indicate cap position to the detector so that color discrimination of the subject may be determined.

Abstract: A personalized hearing profile is generated for an ear-level device comprising a memory, microphone, speaker and processor. Communication is established between the ear-level device and a companion device, having a user interface. A frame of reference in the user interface is provided, where positions in the frame of reference are associated with sound profile data. A position on the frame of reference is determined in response to user interaction with the user interface, and certain sound profile data associated with the position. Certain data is transmitted to the ear level device. Sound can be generated through the speaker based upon the audio stream data to provide real-time feedback to the user. The determining and transmitting steps are repeated until detection of an end event.