Abstract: An improved neurological testing apparatus 10 for examining a person's neurological system has a body housing 12, one or more separate specific taste testing substances 20, one or more separate specific smell testing substances 30, one or more vision charts 40, 42 and a light source 50. The body housing 12 includes a front surface 12A, a rear surface 12B, an upper end 14, a bottom end 16 and an interior chamber 18 for holding a battery 100. The separate specific taste testing substances 20 are attached to the front or rear surfaces. The separate specific smell testing substances 30 are attached to either the front or rear surface. The vision charts 40, 42 lie on one of the front or rear surfaces opposite the smell or taste testing substances 20, 30.

Abstract: A cognitive function training unit including an eye-target showing unit for showing a movable eye-target on a display disposed in front of the subject's eye, an eye movement measuring unit for measuring a position and/or movement of the subject's eye, and a judgment unit for judging whether or not the subject can fixedly look at or follow the eye-target based on the position and/or the movement of the eye-target shown on the display and the position and/or the movement of the subject's eye measured by the eye movement measuring unit, and the eye-target showing unit shows the eye-target repeatedly while changing the position and/or the movement of the eye-target according to a judgment result of the judgment unit. Therefore, it is possible to show a suitable eye-target according to a symptom of a patient, whereby it is possible to conduct training efficiently.

Abstract: For electrophysiological assessment of visual function using a head mounted stereo display (e.g. virtual reality goggles) for displaying a stimulus which is used to generate a retinal or cortical response. In particular, a method for objective electrophysiological assessment of visual function of at least one eye of a subject includes presenting a visual stimulus to at least one eye of the subject, recording at least one of a retinal response and, a cortical response generated as a result of the presenting; analyzing said response and, as a result of said analyzing, forming a map of the visual function of the at least one eye of the subject 6. The invention also relates to as system for such electrophysiological assessment.

Abstract: This invention aims to provide a portable terminal device capable of easily and accurately measuring and evaluating mental fatigue, its measuring method, and a server computer. The portable terminal device includes an operation unit 20; an imaging unit 18 for measuring ambient light; a display screen 16 or light emitting element 17 for displaying a blinking image while a frequency of the blinking image is being changed; and a recording unit 14 for recording a flicker frequency, as a measurement frequency, at the time when a user operates the operation unit 20 to indicate that the user perceives flicker during the display of the blinking image.

Abstract: The present invention discloses a method for comparing the detection of clinically significant diabetic macular edema by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination. Also provided are computer implemented, automated systems for performing the method thereof and computer readable media encoding the method thereof.

Abstract: The subject invention relates to combinatorial analyses of data from two or more diagnostic tests for the detection of eye diseases, simplified interpretation of test results, and assessment of disease stage and rate of change. Of particular interest is to develop combinatorial analyses to improve glaucoma detection and progression rate assessment based on combinations of structural and functional tests. More specifically, approaches are described where data of one or more tests and their normative database are converted to the distribution and scale of another test for further analysis to detect glaucomatous damage; approaches are also described where data of more than one tests are used to assess stage index and rate of change; in addition, methods for displaying the combinatorial analysis results are disclosed.

Abstract: A system for quantifying and mapping visual salience to a visual stimulus, including a processor, software for receiving data indicative of a group of individual's ocular responses to a visual stimulus, software for determining a distribution of visual resources at each of at least two times for each of at least a portion of the individuals. The system further including software for determining and quantifying a group distribution of visual resources at each of the at least two times and software for generating a display of the group's distribution of visual resources to the visual stimulus.

Abstract: A method for diagnosing a disease state in a subject, including examining the subject's eyes in order to determine whether the subject exhibits one or more symptoms of the disease state. Symptoms of the disease state include altered ocular characteristics, such as pupil size, pupil motility, ocular blood vessel coloration, and strobe light cutoff frequency. By evaluating changes to ocular characteristics, a disease state can be diagnosed in a subject. In addition, the severity of the disease state also can be determined.

Abstract: A method and apparatus for utilizing the benefits of encoded signal transmission and reception to enhance the performance of medical testing devices (100) adapted to evoke and measure biological response signals such as auditory evoked potentials (AEP), and the auditory brainstem response (ABR) signals in particular. Auditory stimuli, such as clicks, are presented to the ear of a human patient, in a predetermined encoded sequence, resulting in the generation of auditory responses and bio-electric response signals in the human patient. These response signals from the patient are acquired and observed, and are processed according to the predetermined encoded sequence in which the auditory stimuli were presented to the patient's ear in order to extract the desired auditory evoked potential signals or ABR signals.

Abstract: For electrophysiological assessment of visual function using a head mounted stereo display (e.g. virtual reality goggles) for displaying a stimulus which is used to generate a retinal or cortical response. In particular, a method for objective electrophysiological assessment of visual function of at least one eye of a subject includes presenting a visual stimulus to at least one eye of the subject, recording at least one of a retinal response and, a cortical response generated as a result of the presenting; analyzing said response and, as a result of said analyzing, forming a map of the visual function of the at least one eye of the subject6. The invention also relates to as system for such electrophysiological assessment.

Abstract: An apparatus and method of collecting elements of and assembling various portions of ocular micro motions such as ocular micro-tremor (OMT) movements of the eye, and correlating them directly with OMT waveforms acquired from both known and unknown states of cognition and cognitive function. Comparing newly acquired waveforms from patients with undiagnosed cognitive dysfunctions, permits an individual or caregiver the ability to identify those unknown issues or cognitive states based on matching or relating statistically elements of their waveform with categories of other known cognitive processing normals and abnormals, functional and dysfunctional individuals. It also allows for measuring the effects of therapeutic agents (psychological or pharmacological) by relating them to measurable changes in cognitive function as a result of correlated changes in waveforms.

Abstract: A system for determining the shape of a cornea of an eye illuminates at least one of the interior surface, the posterior surface, and the interior region of the eye with infrared light of a wavelength that can generate fluorescent light from the portion of the cornea illuminated. The generated fluorescent light is then detected. A step of illuminating can comprise focusing the infrared light in a plurality of different planes substantially perpendicular to the optical axis of the eye. From the detected light it is possible to create a map of at least a portion of the interior surface, at least a portion of the posterior surface, and/or portion of the interior region of the cornea. Clarity of vision can be determined by generating autofluorescence from proteins in the pigment epithelial cells of the retina.

Abstract: A head worn device for monitoring alertness and attention which includes a) sensors to monitor eyelid and eye movement, b) a motion sensor and c) data storage means for storing data from said sensors. The motion sensor is an accelerometer to provide data that allows the head position to be analysed and to determine the direction of gaze. The device collects data from an accelerometer worn by the driver to detect if the vehicle is in motion and whether the head is tilted vertical plane. If the vehicle is not in motion data is not processed. When the direction of gaze is downward sensor signals from the eye movement sensors is ignored. However if the duration of downward gaze is greater than a predetermined minimum period and the vehicle is in motion, an alarm is triggered because the driver is inattentive. The device may be used to assess whether workers are sufficiently alert before they commence work.

Abstract: A psychotic manifestation and mental state evaluation apparatus and method which can individually discriminate among symptoms by taking advantage of stimulating Noh mask images and also evaluate with a high probability whether a person is suffering from a specific symptom at the time of diagnosing, clinical examination, assessment, or counseling.

Abstract: The invention provides methods for determining shifts in the attentional state of a subject. These methods are useful for diagnosing subjects with a psychological or behavioral disorder. The invention also features methods for determining the effect of a therapy on the overall attentional state and shifts in the attentional state of a subject.

Abstract: A computationally efficient and robust approach for monitoring the instantaneous pupil response as a correlate to significant cognitive response to relevant stimuli derives data samples d(n) of the pupil diameter (area), v(n) of pupil velocity and a(n) of pupil acceleration from the pupillary response and segments the data samples into a sequence of time-shifted windows. A feature extractor extracts a plurality of spatio-temporal pupil features from the data samples from the response and baseline periods in each window. A classifier trained to detect patterns of the extracted spatio-temporal pupil features for relevant stimuli generates an output indicative of the occurrence of absence of a significant cognitive response in the subject to a relevant stimulus.

Abstract: A method of determining a corneal thickness and an apparatus for determining said is provided. The method comprises the following the steps:—illuminating a cornea by a plurality of stimulator point light sources, capturing an image of the cornea comprising reflected images of the stimulator point light sources, obtaining a model representing an anterior surface of the cornea,—constructing a second model representing a posterior surface of the cornea from the image by ray-tracing the reflected images of the stimulator point light sources towards the model representing the anterior surface of the cornea, determining the corneal thickness from the model representing the anterior surface and the second model representing the posterior surface.

Abstract: Exemplary embodiments of the invention provide a gaze guidance degree calculation system capable of implementing a compact and low-cost apparatus and surely obtaining a proper eye-flow. According to exemplary embodiments, a layout apparatus where a layout image is segmented into a plurality of regions, and positions of representative regions of the specific regions and gaze attraction strength indicating strength of gaze-attraction to the specific regions are calculated. Next, a plurality of the specific regions in the layout image are set by using a starting point as a reference, and gaze guidance strength indicating a degree of gaze-guidance from the starting point to the specific regions is generated based on the gaze-attraction strength of the representative points in the specific regions.

Abstract: For delivery of a chemical to a target region of a subject's brain, an apparatus comprising a storage medium on which is stored digital representations of subject-specific selective visual stimuli that, when viewed, selectively stimulate blood flow to the target area of the brain; and an electronic display device coupled thereto and configured for converting the stored digital representations to images viewable by the subject; wherein the one or more selective visual stimuli were determined by exposing the subject to a plurality of potential stimuli; measuring the blood flow response to multiple regions of the brain, including the target area and one or more non-target areas; comparing the blood flow responses to the potential stimuli, and selecting as selective stimuli potential stimuli that result in relatively more blood flow to the target area and relatively less blood flow one or more non-target areas.

Abstract: A system for quantifying and mapping visual salience to a visual stimulus, including a processor, software for receiving data indicative of a group of individual's ocular responses to a visual stimulus, software for determining a distribution of visual resources at each of at least two times for each of at least a portion of the individuals. The system further including software for determining and quantifying a group distribution of visual resources at each of the at least two times and software for generating a display of the group's distribution of visual resources to the visual stimulus.

Abstract: Methods of implanting an intraocular pressure sensor and systems tbr sensing intraocular pressure are disclosed. An intraocular pressure sensor, including, a top surface, may be placed through the sclera of an eye of a patient. The intraocular pressure sensor may be caused to be inserted into the sclera until the top surface of the intraocular pressure sensor is substantially flush with the exterior wall of the sclera. An implantation wand may be used to assist in the insertion process. The wand may be disengaged from the tntraocuiar pressure sensor after it has been implanted.

Abstract: A computer-controlled sensory testing system is disclosed that can be used to further pain research and aid in the clinical diagnosis and treatment of pain syndromes. The system includes actuators to deliver pressure/deformation (strain), auditory, olfactory, and other stimuli to a subject. The system includes software to control the delivery of the stimuli. The system is further operable to receive feedback regarding the stimuli received.

Abstract: Certain embodiments of the present invention provide a system, method and computer instructions for assessing alertness of an operator of an image review system. In an embodiment, such a system includes: an input module configured to allow alertness data to be input; an alertness assessment module configured to evaluate alertness based on the alertness data; and an output module configured to output information based on the evaluation made by the alertness assessment module. In certain embodiments, the input module may input alertness data from: a three-dimensional coordinate tracking system; a brain wave monitoring device; an eye movement monitoring device; a video recording device; and/or an eye closure monitoring device, for example. In certain embodiments, the alertness assessment module may evaluate alertness data using: a Psychomotor Vigilance Performance Task; the Karolinska Sleepiness Scale; and/or a Visual Analogue Sleepiness Scale, for example.

Abstract: Biosensor, communicator, and/or controller apparatus, systems, and methods are provided for monitoring movement of a person's eye. The apparatus includes a device configured to be worn on a user's head, a light source for directing light towards one or both eyes of the user, one or more image guides on the device for viewing one or both eyes of the user, and one or more cameras carried on the device and coupled to the image guides for acquiring images of the eyes and/or the user's surroundings. The apparatus may include a cable and/or a transmitter for transmitting image data from the camera to a remote location, e.g., to processor and/or display for analyzing and/or displaying the image data. A system including the apparatus may be used to monitor one or more oculometric parameters, e.g., pupillary response, and/or to control a computer using the user's eyes instead of a mouse.

Abstract: Applied kinesiology method and device utilizes an examiner's autonomic response to truth/false or beneficial/non-beneficial stimulus and provides immediate feedback to the examiner in the context of an applied kinesiology exam. Kinesiology glasses detect local pupillary response to truthfulness locally and remotely. Through measurements of the pupils dilation or constriction and processing of the measurements, the response is obtained and feedback, via sensory stimulation, is provided to the examiner that reflects the pupillary response. The device and method effectively eliminate the subjective components of prior art muscle testing response from the hands of the testing examiner.

Abstract: The invention provides easy handling and low cost-support equipment for measuring optical nerve-activity which is less stressful for subjects or doctors and the like. The support equipment, which provides light stimulation for subject eyes with its main body 10 fixed to the subject-head region and measures the subject optical nerve-activity, comprises a thin walled-main body 10 with a plurality of optical fibers 11 joined in the width direction; light emission regions 13a, 13b at least one of which is positioned in the main body aligned to the subject eye-position(s) and composed of a plurality of light leak parts 11c formed in peripheral surfaces of the optical fibers 11; and a connector 12a for connecting with a light emission device 12 providing light for each of the plurality of optical fibers.

Abstract: A method is presented to address quantitative assessment of visual form discrimination in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, said scene comprising a plurality of elements and a background; (2) distorting at least one geometric characteristic of at least one; (3) modulating the contrast level of the predetermined section of the scene; (4) moving the predetermined section relative to the scene, the movement being tracked by said subject via at least one input device; (5) receiving feedback from the subject via the input device; (6) quantitatively refining the received feedback relative to the scene; (7) adjusting at least one distorted geometric characteristic relative to the accuracy of the quantitatively refined feedback; (8) calculating the critical threshold parameter for the subject; and (9) recording the critical threshold parameter onto a tangible computer readable medium.

Abstract: A method is presented to address quantitative assessment of functional impairment in a subject, where the method comprises the steps of: (1) presenting a plurality of tests to a subject on a display, the plurality of tests comprising a series of scenes, the scene comprising at least one stimulus, wherein the scene may be associated with visual, auditory, and tactile stimulus arrays; (2) modulating at least one spatial characteristic of at least one stimulus; (3) receiving feedback from the subject via at least one input device; (4) quantitatively refining the scene relative to the received feedback; (5) calculating the relationship between at least one of the scene, the stimulus, and the quantitatively refined scene; (6) adjusting the scene relative to the calculated relationship; (7) determining equilibrated scene parameter of the subject; (8) recording the equilibrated scene parameter onto a tangible computer readable medium; (9) generating at least one diagnosis to the functional impairment associated with

Abstract: Methods for diagnosis and treatment are provided for a patient having processing difficulties, integration problems, imbalances or abnormal postures. In one embodiment, a patient is identified having retinal signal problems creating at least one negative medical condition. Then the amount of a natural hormone in the eye is increased such that, as a result of the diagnosis and treatment, the patient achieves improved retinal signal processing and at least one of the patient's negative medical conditions is improved. Other embodiments include using the treatment in combination with the Z-Bell Test and/or light blocking or altering devices for diagnosis and treatment.

Abstract: A method is presented to address quantitative assessment of visual motion discrimination in a subject, where the method comprises the steps of: (1) presenting a scene, comprising a plurality of elements and a background, to a subject on a display; (2) moving a plurality of elements relative to the scene; (3) receiving feedback from the subject; (4)quantitatively refining the feedback; (5) modulating the movement relative to accuracy of the received feedback; (6) monitoring the response error; (7) calculating a critical threshold parameter for the subject; and (8) recording a critical threshold parameter onto a tangible computer readable medium. An apparatus for quantitative assessment of visual motion discrimination of a subject comprising a display device, an input device, a control device, and a tangible computer readable medium. In its simplest sense, a quantitative assessment profile of visual motion discrimination by psychophysical responses is generated on a tangible computer readable medium.

Abstract: A method is presented to address quantitative assessment of spatial distractor tasks in a subject, where the method comprises the steps of: (1) presenting at least one scene to a subject on a display, said scene comprising a plurality of elements and a background; (2) modulating the saliency of a predetermined section of the scene; (3) receiving feedback from the subject; (4) superimposing an additional cue onto the scene; (5) generating a shift in attention of the subject; (6) receiving refined feedback from the subject; (7) quantitatively refining the refined feedback; (8) adjusting the motion associated with the scene relative to accuracy of the refined feedback; and (9) calculating a critical threshold parameter for the subject; and (10) recording the critical threshold parameter onto a tangible computer readable medium. An apparatus for quantitative assessment of spatial distractor tasks of a subject comprising a display device, an input device, a control device, and a tangible computer readable medium.

Abstract: A method for determining the quantity of an analyte in a fluid is described along with various components of an apparatus designed to carry out the method. The method involves habituating a patient's eye to one or more colors, measuring the recovery time, and correlating the recovery time to the quantity of the analyte. A reproducible, objective, non-attentiveness-dependant test for assessing analyte levels is further disclosed. To this end, a device that measures saccadic eye movements may be used to assess the return of vision to the prehabituated state. The method and apparatus are particularly suited for noninvasively measuring blood glucose levels.

Abstract: Structure and methodology involving mountable and head-wearable frame structure which is positionally stabilized, during use, relative a human subject's head, and which carries a selection of positionally anchored data sensors, and stimuli deliverers, that are relevant to the diagnosis and treatment of vestibular disorders. Special configurations are provided for two types of stimulators, one for sound application and air-pressure modification, and the other for the introduction of fluids to the ear. Stabilization enables tight and accurate correlation of data which is quickly analyzable by a connected, properly algorithmed computer, which can also be used for feedback control in a designed “expert” system. The invention enables, among other things, practical and significant differentiation between physiological and pathological nystagmus.

Abstract: Eyetracking techniques and analysis techniques are disclosed. At least one interpretation of eyetracking data is received from an eye interpretation engine. A characteristic of an application is dynamically modified based on the interpretation of the eyetracking data. A portion of the application being viewed by a user may be determined. The determined portion may be modified in response to the interpretation of the eyetracking data for the user.

Abstract: An ophthalmic method for determining a relationship between aphakic ocular power and estimated effective lens position (ELP) of an intraocular lens (IOL) to be implanted in a patient's eye. The method can be used to determine an estimate of the ELP of an IOL given the aphakic ocular power of the patient's eye, for example, without measurement of the corneal curvature or axial length of the patient's eye. The estimate of ELP can then be used to determine a suitable value of optical power for the IOL to be implanted in the patient's eye.

Abstract: The present invention provides a method of evaluating the human subconscious response to smell and a method of evaluating a subject's subconscious response to an aroma stimulus.

Abstract: Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.

Abstract: The present invention describes a novel device for the stimulation of the visual system for the purpose of recording evoked responses. The specific features of the device are particularly relevant to the elicitation of such responses in uncooperative subjects including the mentally impaired, young children, and those under the influence of anesthesia.

Abstract: Structure and methodology involving mountable and head-wearable frame structure which is positionally stabilized, during use, relative a human subject's head, and which carries a selection of positionally anchored data sensors, and stimuli deliverers, that are relevant to the diagnosis and treatment of vestibular disorders. Special configurations are provided for two types of stimulators, one for sound application and air-pressure modification, and the other for the introduction of fluids to the ear. Stabilization enables tight and accurate correlation of data which is quickly analyzable by a connected, properly algorithmed computer, which can also be used for feedback control in a designed “expert” system. The invention enables, among other things, practical and significant differentiation between physiological and pathological nystagmus.

Abstract: The invention relates to systems and methods for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal. The methods include separating a measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal and generating a template signal representing the plurality of segments. The methods further include calculating a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, and determining a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal.

Abstract: The invention relates to a method for testing visual field of a patient with use of a computer system (7) connected to an output-matrix of light points (6) having controlled brightness and to an input device (4) for measurement of patient's reaction.

Abstract: A system for testing a subject for cognitive impairment includes a display, one or more video cameras and a computer. The display presents to the subject multiple stimuli, including a predictable, smoothly moving object, repeatedly moving over a same path. The video cameras sense eye movements of the subject, while the subject visually follows the object on the display. The computer analyzes the subject's eye movements to determine, for example, accuracy and variability of the subject's visual pursuit of the display of the smoothly moving object, and determines, based on the analysis, if the subject has a cognitive impairment. The analysis may provide one or more metrics, such as a metric of attention, a metric of fatigability and a metric of distractibility. The system may also be configured to provide feedback signals to the user, in which case the system also functions as cognition timing and motor training system.

Abstract: A method and apparatus for measuring corneal resistance to deformation use an empirically derived function wherein an inward applanation pressure P1 and an outward applanation pressure P2 obtained during a corneal deformation cycle caused by a fluid pulse are separately weighted so as to minimize dependence of the calculated corneal resistance factor (CRF) on intraocular pressure. In one embodiment, the function is optimized, at least in part, to maximize statistical correlation between the calculated corneal resistance factor (CRF) and central corneal thickness.

Abstract: The present invention provides a device and method for evaluating sympathetic function using electrooculography having advantage of simply analytical process and portability. The device for evaluating sympathetic function using electrooculography mainly comprises a plurality of electrode pastes and an electrooculography detector. Moreover, the structure of the device is further selected from the group consisting of necklace, hat block, adhesive bandages, and button. In practice, the device and method for evaluating sympathetic function using electrooculography according to the present invention utilizes a technology of micro physiological wireless transmitter and sensing synchronizing with analysis to be a simple and precise detective tool of detecting sympathetic function with electro-oculogram (EOG).

Abstract: The invention relates to ocular stimulation and posturography equipment, characterized in that it comprises, in combination: a support capable of being removably fastened to the subject's head and including at least one ocular sight device to be placed facing one eye of the subject, each sight device comprising a display screen and a hollow body, in which the screen is placed, and being designed to be placed facing a single eye of the subject and to minimize the visual reference marks for the patient other than those displayed on the screen; means for detecting significant body reactions in the patient, which are capable of delivering measurement signals representative of significant body reactions; means for the acquisition and recording of the measurement signals delivered by the detection means; means for synchronizing the transmitted image signals and the received measurement signals so as to be able to correlate these two types of signal.

Abstract: A method and apparatus for measuring drowsiness particularly in vehicle operators measures the amplitude to velocity ratio for eyelids closing and opening during blinking as well as measuring duration of opening and closing. The average values for the amplitude to velocity ratios for opening and closing are weighted and added to give a drowsiness measure that is compared to a scale of drowsiness based on data collected from alert and drowsy subjects. Other eye movements can be used in the weighted algorithm. The scale of drowsiness predicts the onset of drowsiness levels that render an operator unfit to continue.

Abstract: A method for measuring the dynamic behavior of an optical system is aimed at rendering the dynamic behavior of the optical system objectively detectable. To this end, the optical system to be measured is stimulated by stimuli whereby causing it to react, and the reaction is detected by means of a wave front analysis.

Abstract: An eye gaze tracking apparatus (100) includes: an electro-oculogram measuring unit that outputs an electro-oculogram original signal; a calibration index presenting unit (103) that presents a calibration index to a user; a saccade detection unit (104) that outputs an electro-oculogram change amount that is an amount of change in an electro-oculogram before or after a saccadic movement which is measured when a gaze-path position of the user moves to the calibration index; a calibration parameter calculating unit (105) that calculates a calibration parameter based on a position of the calibration index and an electro-oculogram change amount; and a calibration unit (101) that detects the gaze-path direction of the user from the electro-oculogram original signal.

Abstract: A system to measure a subject's gaze stability, comprising: a display device; a data processor in communication with the display device; a data input device in communication with the data processor; and a motion detector in communication with the data processor, the motion detector being adapted to be worn by the subject under observation, wherein the data processor is configured to cause the display device to display a predetermined visual target based on a motion signal detected by the motion detector, the data processor is adapted to receive information from the data input device concerning a response of the subject in identifying the predetermined visual target, and the data processor is further adapted to generate an output characterizing the subject's gaze stability based on the received information.

Abstract: Neurophysiological responses such as EEG signals of brainwave activity, dilation signals of pupillary response, dwell time signals of eye movement and imaging signals of vascular response are monitored as a correlate of the operator's cognitive response. These responses are processed to determine if there is a significant cognitive response to a stimulus (visual or non-visual) to generate a positive cue. The operator's eye movement is monitored to determine when the operator fixates on the stimulus and the position of the stimulus in the operator's field-of view (FOV). The positive cue and position of the stimulus, and typically the time-stamp of the cue are output triggering a system response. The temporal sequence of cues and stimulus position may be processed to reinforce or reject the cue or refine the stimulus position.