Abstract: Method and device are provided for evaluating the pleural space. The device in introduced percutaneously into a pleural space. The device includes an energy detector that facilitates evaluation of the pleura. The device also includes a tissue collection component and a joint. The joint allows the device to be bent at least 120 degrees, facilitating assessment of the pleura. The device allows tissue sampling when the device is bent. The method encompasses selective tissue sampling of the parietal pleura without inducing pneumothorax, with its attendant extended recovery time, in the patient. The distal portion of the device is introduced percutaneously into the pleural space. The pleura near the access point is evaluated using an energy emitter and energy receiver integrated into the device and a portion of the parietal pleura near the access point is sampled using a biopsy tool integrated into the distal portion of the device.

Abstract: A biopsy tool includes an elongated flexible body, a sensor assembly, and a screw member. The sensor assembly is disposed within the elongated flexible body towards the distal end thereof. The sensor assembly includes a location sensor(s) configured to enable detection of a location of the sensor assembly. The screw member is coupled to the distal end of elongated flexible body, extends distally from the elongated flexible body, and is positioned distally of the sensor assembly. The screw member defines a helical configuration having a hollow interior and is configured for simultaneous rotation relative to tissue and advancement into tissue to obtain a tissue sample.

Abstract: Some embodiments of a biopsy system are configured to obtain a sample of tissue from an internal body site, such as a portion of myocardial tissue from a heart chamber wall. The biopsy system may include a catheter device having tissue collection jaws and an inflatable balloon disposed along a distal portion. Also, the biopsy system may include a pressure sensor device to detect the pressure within the heart chamber in which the tissue collection jaws are disposed.

Abstract: An endoscope for removing tissue at a surgical site includes an elongated tubular body insertable within a mammalian cavity of a patient. An instrument channel extends between a first opening at a distal end and a second opening at a proximal end of the tubular body and is sized and configured to receive a surgical cutting assembly that includes an aspiration channel configured to remove material entering the endoscope via a distal end of the surgical cutting assembly. A torque generation component configured to generate torque is positioned within the distal end and configured to provide the generated torque to a coupling component. The coupling component is positioned at the distal end of the elongated tubular member and configured to actuate a cutting component of the surgical cutting assembly responsive to actuation of the torque generation component.

Abstract: A microbiopsy device for taking biological samples, comprising a body including two or more cutting elements for cutting tissue to form a biological sample; and a chamber inside the body for receiving and retaining the biological sample, the chamber having an opening between the cutting elements, wherein the cutting elements are arranged to cut a section of tissue having a width of less than 1 mm.

Abstract: A medical instrument is disclosed, which includes an elongated member having a plurality of joint members arranged side by side in an axial direction, the elongated member taking a first form that is bendable in a direction intersecting with the axial direction when the joint members are arranged with gaps therebetween in the axial direction and taking a second form having rigidity when the distance between the joint members is reduced in the axial direction to be narrower than the distance in the first form, a gripper capable of gripping an object to be gripped, and a first push-pull member and a second push-pull member each movable along the axial direction of the elongated member. Operating the first push-pull member and the second push-pull member enables the elongated member to be switched between the bendable first form and the rigid second form and enables an opening-closing operation of the gripper.

Abstract: The invention relates to a device for taking a liquid bone marrow sample (aspiration) and a solid bone sample (biopsy) in the same procedure, which can thus replace specialized needles for taking bone marrow and needles exclusively used for taking bone biopsies. The device for taking liquid bone marrow samples and a solid bone sample has a simple mechanism that uses two grooved clamps, it is easy to disassemble for sterilization and its handle is designed to perform the puncture easily. The needle of the device is hollow, and within it a guide is placed with two sections of different diameters. The guide makes it possible to open up the empty needle channel to allow the bone marrow liquid to flow and be extracted, and also to close the channel to be able to penetrate the tissue. The purpose of this invention is to combine the procedures of bone marrow aspiration and bone biopsy, thus reducing the patient's discomfort and the time needed for the procedure.

Abstract: An excisional biopsy and delivery device may comprise one or more rotating, penetrating and cutting rod elements. The rod elements may be configured to advance from a stored and confined first position and rotate about an axis, while being simultaneously revolved about a central axis. The rod elements may then assume a second released and expanded configuration that is operative to cut around and surround target tissue. In this manner, the rod elements are operative to move through the surrounding tissue to create a volume of revolution and to sever and capture the target tissue contained within the volume of revolution from the surrounding tissue. The severed and captured volume of revolution containing the target issue may then be removed.

Abstract: An excisional device for either handheld or stereotactic table/MRI use may comprise a work element configured to rotate at a first rotation rate and comprising at least one articulable beak configured to cut tissue in a longitudinal direction. Helical elements or equivalent assemblies may be configured to transport tissue cut by a work element and may be co-axially disposed relative to the work element and may be operative to rotate at rotation rates that may be different from the work element rotation rate. Flush and vacuum tissue transport mechanisms may be incorporated in replacement of or in conjunction with helical elements. A proximal sheath and a distal sheath may be co-axially disposed relative to a work element and may be configured to rotate a work element and to actuate a beak or beaks. A simplified embodiment of this device may be applicable to field use where power sources for actuation may be limited.

Abstract: A tissue harvesting and processing apparatus comprises a body and a distally extending needle. The needle includes an aperture configured to receive tissue. A tissue cutting member is movable relative to the needle to sever a specimen from tissue protruding through the aperture. The tissue cutting member is further operable to mince the severed tissue specimen. The minced tissue may be mixed with a medical fluid component contained in a reservoir. A plunger may expel the medical fluid mixture from the needle. An applier tip may be coupled with the needle to facilitate administration of the medical fluid mixture at a target site in a patient. The needle may comprise a cannula with a needle adapter, which be removed from the cannula to allow the applier tip to be coupled with the cannula. The tissue cutting member may comprise a perforated disc or tube with inwardly projecting blades.

Abstract: A biopsy device for acquiring a tissue sample is disclosed. The biopsy device comprises a partoff mechanism which can have at least a tab and an actuator. The actuator can be used to control the angle of the tab and thus partoff a tissue sample. The tab may be on a cutter tube, which may have a sharp distal end which may core the samples from the mass of tissue. Multiple tissue samples may be collected.

Abstract: Among other things, there is disclosed a biopsy needle capable of taking samples of varying size. In particular embodiments, a user selects one of a plurality of sample-size settings, which sets the needle to a particular cannula throw-length by moving an internal wall against which a spring engages. For a shorter throw, the wall is in a forward position and the cannula is retracted the smaller amount to compress the spring. For a longer throw, the wall is in a rearward position and the cannula is retracted a larger amount to compress the spring.

Abstract: An apparatus and method are provided for sampling the distal tube, fimbria and/or ovary, includes advancing a device into the peritoneal cavity and sampling material on or adjacent to the distal tube, fimbria or ovary.

Abstract: The present invention is a device, system and method for surgical soft tissue lesion excision. The device is designed to be placed into a soft tissue lesion preferably under radiologic guidance and deployed. Once deployed, the shape memory wires of the soft tissue encompassing element form a wire cage surrounding the lesion which acts as an excision guide, encompassing and protecting the lesion during surgical excision of the lesion.

Abstract: A biopsy device includes a biopsy sample extraction needle with a sample extraction end and a recovery end. A transport channel links the extraction end and recovery end. A pump is provided, and a multi-way valve is coupled in fluid communication with the biopsy sample extraction needle and the pump. The multi-way valve has a plurality of settings.

Abstract: A biopsy needle (80) having a longitudinal channel (84) formed within an inner conductor (86) of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip (82) e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 to 100 GHz) delivered to the coaxial antenna is emitted at the insertion tip. The insertion tip may be arranged to match the impedance of the coaxial antenna to a predetermined tissue impedance. The emitted radiation can be used to measure properties of or treat (e.g. ablate) tissue at the insertion tip. Needle biopsy apparatus is also disclosed, in which a microwave energy is controllably delivered to a needle from a microwave generator. The apparatus may include an impedance tuner to dynamically match the impedance of the needle with tissue at the insertion tip.

Abstract: Tissue can be removed from a patient with a catheter or other medical device having a cutting member. A source of suction can be coupled to the device for suctioning removed tissue through a lumen in the device and out of the patient's body.

Abstract: A kit for implantation of material into a body, a kit for extraction of tissue from a body and a tissue transplantation kit. A method for implanting material into a body, a method for extracting tissue from a body and a method for transplanting tissue into a body.

Abstract: A marker deployment tool may comprise a marker cannula having a lateral deployment aperture, a push rod slidably disposed within the marker cannula and a scalloped tip coupled to the distal end of the marker cannula. The scalloped tip may have a push rod recess configured to receive a portion of the distal end of the push rod such that the push rod does not appreciably extend out of the lateral deployment aperture when the push rod is actuated distally. The marker deployment tool may further comprise a magnet at or near the distal end. This magnet may be used in combination with a magnet or plurality of magnets disposed about an access chamber in a tissue sample holder to assist the user in aligning the marker deployment tool. The access chamber in the tissue sample holder may also include a valve, two valves, or a removable plug.

Abstract: A device and method for collecting a tissue sample. The device includes a blade comprising an anterior portion and an elongated blade body. The elongated blade body is substantially firm and the anterior portion is bendable. The anterior portion comprises a sharp or pointed anterior end adapted to pierce and penetrate into tissue and a sampling mechanism with at least one recess or notch disposed therein or a sampling channel to collect the tissue sample. The sheath comprises an elongated body having an interior lumen, and an arcuate slot corresponding in shape to the blade and forming a continuum between the interior lumen and an exterior aperture laterally on the body of the sheath.

Abstract: A method of removing material from a blood flow lumen includes providing a device having a cutting element and an opening, the cutting element being movable relative to the opening. The method then includes advancing the device through a patient's vascular system to the blood flow lumen. Finally, the method involves moving the cutting element and the opening relative to the blood flow lumen so that a continuous piece of material is severed by the cutting element and directed into the opening as the cutting element and opening move through the blood flow lumen, the continuous piece of severed material being directed into the device for removal from the patient. The method may include providing a device having a rotatable cutter that, in some embodiments, is not parallel to the longitudinal axis of the device, is movable, has retracted and deployed positions, or any combination thereof.

Abstract: The present invention provides novel methods and devices for detection of pathogens or other microbes in an analyzed sample (e.g., food, industrial, pharmaceutical, botanical, environmental etc., sample). The inventive methods and devices provide for increasing the power of detection for pathogens on food surfaces, comprising increasing the number of independent, discrete samples taken during the sampling procedure. The inventive sampling device reduces sampling costs by minimizing time, material and product loss relative to prior art sampling techniques. In particular aspects, a novel surface sampling device for bulk solid foods is provided that operates to remove (e.g., shave) small pieces from contacted product (e.g., product pieces). The device comprises a sampling mechanism having utility to remove samples (e.g., cut slivers from) larger pieces of food or other sample materials. In particular embodiments, the device comprises a primary shaft member (e.g.

Abstract: Instruments, systems and methods are provided for performing submucosal medical procedures in a desired area of the digestive tract using endoscopy. Instruments include a safe access needle injection instrument, a submucosal tunneling instrument, a submucosal dissection instrument, a mucosal resection device. Systems include a combination of one or more of such instruments with or without injectable agents. Embodiments of various methods for performing the procedures are also provided.

Abstract: A tissue sample securement apparatus secures a volumetric tissue sample. The tissue sample securement apparatus according to the present invention includes an expandable-retractable tissue sampling device, which tissue sampling device includes an axial displacement member, an expandable tip construction, and a tensile member. The axial displacement member includes a distal member end and a proximal member end. The tip construction extends from the distal member end, and the tensile member extends in adjacency to the axial displacement member and is connected to the tip construction for selectively retracting a member-retractable distal portion of the tip construction. The selectively retracted distal portion simultaneously severs and secures a volumetric tissue sample. The tissue sample may then be retrieved via a catheter member for directing the device to and from the target tissue mass.

Abstract: An improved flexible endoscopic instrument to precisely and efficiently obtains samples of flat polyps and multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope. In one aspect, the cutting tool is coupled to a flexible torque coil or torque rope that is configured to transfer rotational energy from a powered actuator through the length of the endoscope onto the cutting tool.

Abstract: Apparatus (20) is provided for use in a gastrointestinal tract (40) of a patient, including an inflatable device (22) configured to be moved through the gastrointestinal tract (40) to a treatment site in response to a difference between fluid pressure proximal to the inflatable device (22) and fluid pressure distal to the inflatable device (22). An optical system (24) coupled to the inflatable device (22) configured to image the gastrointestinal tract (40). A working channel (32) coupled to the inflatable device (22) and shaped to define a channel lumen therein to provide access from outside of the patient to the treatment site. A tool (34) configured to be passed through the channel lumen and to emerge from a distal end of the working channel (32). The tool (34) comprises a tool steering mechanism (44) to facilitate steering of the tool (34) from outside of the patient. Other embodiments are also described.

Abstract: Aspects of the present invention are generally directed to a biopsy device configured to engage target tissue within a patient and to remove a sample of the target tissue from the patient. The biopsy device comprises an elongate catheter configured to be inserted into a patient. A coring component is disposed at the distal end of the catheter to sample the target tissue.

Abstract: Claimed is an imaging and diagnostic system and method for focal scanning of a specimen using optical projection tomographic microscopy and computer generation of three-dimensional images. One embodiment comprises a light source and an imaging system having an adjustable focal position which acquires a plurality of digital 2D projection images of biological tissue placed within a specimen tube that translates and rotates past an optical lens in a helical pattern. A computer captures the images and generates a 3D composite image. Also claimed is a system and method for preparing a specimen for optical microscopy. One embodiment comprises fixing, staining, and/or optically clearing biological tissue within a microfluidic specimen chamber prior to placement in a specimen tube.

Abstract: Biopsy devices and methods useful with Positron Emission Tomography (PET) and Breast Specific Gamma Imaging (BSGI) are disclosed. A biopsy device including a flexible tube having a side aperture, and a PET or BSGI imageable material disposed within the flexible tube is disclosed. A biopsy method is disclosed that includes advancing a flexible tube having a PET or BSGI imageable material distally through the biopsy device. Various other embodiments and applications are disclosed.

Abstract: A biopsy device may include a needle, a cutter, and a handpiece. A vacuum pump may be provided in the handpiece for providing a vacuum to the needle and/or to the cutter. A motor may be provided in the handpiece to drive the vacuum pump and/or the cutter. A biopsy device may also include a valving mechanism within the handpiece for selectively communicating a vacuum and/or atmospheric air to the needle. A clutching mechanism may selectively provide communication between a motor and the cutter. Portions of a valving mechanism and a clutching mechanism may be integrally formed. A clutching and valving mechanism may be driven by a first motor; and a cutter and vacuum pump by a second motor. A biopsy device may include batteries for powering motors. A biopsy device may thus provide vacuum and power from within a handpiece, such that the biopsy device is tetherless.

Abstract: A tissue-sampling tool is made in the form of a tube presenting an inside face of circular section and an outside face of circular section, the tube having a blunt distal end and at least one sampling orifice extending symmetrically relative to a transverse plane and to a longitudinal plane. The orifice is peripherally bordered by two transverse borders that are symmetrical relative to the transverse plane and that are connected to two longitudinal borders that are symmetrical relative to the longitudinal plane. Each transverse border possesses a cutting edge situated at the intersection between said borders and the inside face, each transverse border co-operating with the inside face to form a cutting angle lying in the range 6° to 18°. The longitudinal borders have a cup-shape relative to the transverse borders, with a profile in the longitudinal plane that is different from the profile of the transverse borders.

Abstract: A biopsy system includes a biopsy targeting assembly, a needle, and a biopsy device. The biopsy targeting assembly includes a cradle. The needle is releasably supported by the targeting assembly. The biopsy device includes a body having a tissue collection assembly and a cutter. The cutter is translatable relative to the body and extends distally from the body. The cradle of the targeting assembly releasably supports the body of the biopsy device distally of the tissue collection assembly. The biopsy device translates a distal portion of the cutter within the needle with the needle supported by the targeting assembly.

Abstract: Devices and methods for transplanting tissue for the purpose of regeneration, for treating a patient having injured myocardial tissue, and/or for improving cardiac function through cell regrowth. More specifically, the devices and methods obviate the need for cellular alteration. The devices comprise a hollow tube with a sharp distal end, a stylet that is disposed and movable within the hollow tube, and a stopping device that constrains movement of the stylet. The methods comprise removing intact tissue from a first region of a mammalian organ and implanting the tissue in a second region of the same organ.

Abstract: This disclosure includes various embodiments of couplers for coupling intraosseous (IO) devices and drivers, and various embodiments of drivers and kits.

Abstract: A biopsy forceps system including a biopsy forceps tool having a first jaw and a second jaw, wherein each of the first jaw and second jaw has a cutting edge and wherein a portion of at least one of the first jaw and the second jaw has a micropatterned polymer coating thereon.

Abstract: A tissue sampling device includes for removing tissue from a target area in the body comprises a shaft having an outer surface. Two first portions and two second portions of the outer surface extend lengthwise of the shaft. Each first portion of the outer surface is associated with a different second portion and is spaced apart from its associated second portion. Each first portion of the outer surface at least partially defines a cutting edge extending in a straight line lengthwise of the shaft. Each first portion of the outer surface and its associated second portion are associated with a tissue-receiving surface extending lengthwise of the shaft. Each tissue-receiving surface defines a depression for receiving a tissue sample removed from the target area by the cutting edge of the associated first portion of the outer surface when the shaft is rotated about its longitudinal axis in the target area.

Abstract: A novel capture device apparatus comprising: (a) a capture device portion, at least a part of which is adaptable for insertion into a patient and (b) a control unit. The capture device portion comprises one or more apertures and one or more electroactive polymer actuators that open and close the one or more apertures based on control signals sent from the control unit. In another aspect of the present invention, a method of capturing a specimen within a patient's body of provided. The method comprises (a) providing a capture device apparatus like that above, (b) inserting at least a portion of the capture device portion of the apparatus into the patient such that the capture device portion is adjacent the specimen; and (c) closing the one or more apertures using the control unit, thereby capturing the specimen.

Abstract: The invention relates to a system for collecting at least one sample of animal tissue, including: a sampling device, including at least one cutting element for cutting off a sample of animal tissue, and a storage device including a receiving tube for receiving said sample. According to the invention, the system includes a weighted element (22) configured so as to assume at least two positions, i.e. a first position which is assumed prior to collecting said sample and in which said weighted element (22) is retained in said sampling device or in said storage device, and a second position which is assumed after said sample is collect and in which said weighted element (22) is free within said tube, said weighted element (22) being pushed inside said tube during said sampling.

Abstract: A method is provided for calibrating a surgical biopsy system. The biopsy system includes a biopsy instrument and control unit. The biopsy instrument includes a piercer, rotatable cutter, and a port for receiving tissue samples. The method comprises the steps of translating the cutter distally until the translation of the cutter is stopped at an extended position and recording the extended position. The cutter is then translated from the extended position proximally until the translation of the cutter is stopped at a retracted position proximal to the extended position. The retracted position is recorded. The method further comprises the step of rotating the cutter to a rotation speed while the cutter is located at the retracted position and, if determined that the rotation speed is within a predetermined rotation speed range, a feedback signal is provided on the display allowing the operator to progress to the next procedural step.

Abstract: A medical tool for removing tissue includes a removing device for the mechanical removal of tissue, and a magnet for the magnetic attraction and collection of magnetic or magnetizable particles.

Abstract: Tools and methods are provided for removing biological units from a body surface utilizing a removal tool. The tools may incorporate retention members and mechanisms configured to impede movement of the biological unit in the direction of a distal end of the tool and to improve retention of the biological unit in the tool. Some of the retention members are stationary and some are movable within the lumen of the biological unit removal tools. The distal tips of the tools are desirably configured to reduce the chance of transection of a biological unit, such as by including both cutting segments and blunt relief segments. A number of dual concentric tube embodiments permit a division of removal functions. Distal fluid or gas delivery may supplement a vacuum in a luminal space to help extract biological units from surrounding tissue.

Abstract: A rongeur including a stationary shaft having a length that terminates in a foot plate, a cutting slide slideably coupled with the stationary shaft and terminating in a cutting edge, a breach extending between the foot plate and the cutting edge for receiving human tissue, and handle means for slidably moving the cutting slide longitudinally relative to the shaft member. The cutting slide is provided with a pair of opposing tracking arms arranged about a distal end of the cutting slide and a third tracking arm arranged about the proximal end of the cutting slide. The tracking arms are slidably and detachably received within corresponding tracking slots in the shaft member when the rongeur is in a closed position. The tracking arms are disengaged from the tracking slots by rotating the cutting slide about a pivot axis that extends substantially parallel to the length of the shaft member thereby placing the rongeur in an open position.

Abstract: A biopsy device may comprise a probe assembly that has a needle assembly extending distally from the probe assembly. The needle assembly has a needle portion and blade assembly. The blade assembly comprises a blade and a multi-member coupling assembly. The multi-member coupling assembly is configured to couple to the blade and to the needle portion to attach the blade to the needle portion. In one configuration the multi-member coupling assembly comprises two coupling members configure to couple to the blade. The blade may be a flat blade that has a retention channel formed therein, wherein the two coupling members may couple to the blade at the retention channel. The needle portion may comprise a needle and a cutter receiving tube. The needle may be an ovular cross-sectioned tube having a cut-out portion into which a circular cross-sectioned cutter receiving tube may be inserted and coupled thereto.

Abstract: A micro spike having a three-dimensional structure made of single crystalline silicon and being capable of picking an enough amount of a tissue to examine the tissue while minimizing an examinee's pain with a minimal invasion when picking the tissue and a method of manufacturing the same are disclosed. The micro spike comprising: a main body part; extension parts inserted into a tissue when picking the tissue sample and integratedly extended from upper and lower parts of one side of the main body part; and a protrusion part integratedly protruded from at least one of side surfaces of the extension parts and inserted into the tissue to pick the tissue sample together with the extension parts when picking the living tissue sample.

Abstract: A graphical user interface is disclosed for a tissue biopsy system having a tissue cutting member adapted for cutting one or more tissue specimens from tissue at a target site within a patient. The graphical user interface includes a first GUI area representing a first region of the target site from which the tissue cutting member has separated one or more tissue specimens. The graphical user interface further includes a second GUI area, visually distinguishable from the first GUI area, representing a second region from which the tissue cutting member may separate one or more additional tissue specimens from tissue at the target site.

Abstract: A novel catheter is described. The catheter comprises a handle, an inner sheath providing an inner sheath lumen extending along a first length from a proximal inner sheath portion supported by the handle to a distal inner sheath portion connected to a cage gripper, and an outer sheath having a second length extending from a proximal outer sheath portion supported by the handle to a distal outer sheath portion connected to a cage housing. The inner sheath rotatably resides inside the outer sheath with the cage gripper rotatably housed inside cage housing. During a surgical procedure, a distal bridge portion of the inner sheath is connected to an opening in the lead sidewall with the lead received inside the cage housing. A gear knob is manipulated to cause the inner sheath to rotate with respect to the outer sheath so that the cage gripper is moved from an un-deployed position housed inside the cage gripper to a deployed position completely surrounding the lead connected to the distal bride.

Abstract: A biopsy device includes a probe, a holster, and a tissue sample holder for collecting tissue samples. The probe includes a needle and a hollow cutter. The tissue sample holder includes a housing having a plurality of chambers that are respectively configured to receive a tray. The housing is releasably engageable with the probe. Each tray is configured to receive a tissue sample communicated through the cutter lumen. Each tray is removable from the housing, such as along an axial direction. The tissue sample holder is rotatable to successively index each chamber to the cutter lumen. A tray retainer is operable to selectively secure the trays relative to the housing. The trays may be flexible, resilient, or rigid.

Abstract: An impact biopsy device is disclosed. The impact biopsy device may be configured to displace various cutting elements, such as an outer tubular member and cutting element and a cannula to sever a tissue sample from a patient. The impact biopsy device may comprise an actuation system configured to transfer displacement or force to the cutting elements by the impact of an element on another element.

Abstract: Catheters, kits, and methods are provided for removing material from a body lumen. The catheters and methods may be used in a variety of body lumens, including but not limited to coronary and other arteries. In general, the catheter has a cutting element that cuts material while the material is engaged by a material capture device on the catheter body. Preferably, the material capture device tensions the material during cutting, which reduces the amount of cutting force required. The material capture device typically follows a path that draws material into the catheter body. Preferably, but not necessarily, the material capture device may be arranged on the catheter body to advance along a path outwardly from the catheter body into the material and then inwardly towards the catheter body to tension the material. The cutting element on the catheter body moves between a first position and a second position to cut the material while in tension.

Abstract: The present invention provides for exemplary embodiments of a single-insertion, multiple sampling biopsy device. Exemplary embodiments of a single-insertion, multiple sampling device with integrated marker release.