Injectors/holders For Seeds Or Implants (e.g., Capsules) Patents (Class 600/7)
  • Patent number: 11253352
    Abstract: Embodiments of the present disclosure are directed to a phototherapy eye device. In an example, the phototherapy eye device includes a number of radioluminescent light sources and an anchor. Each radioluminescent light source includes an interior chamber coated with phosphor material, such as zinc sulfide, and containing a radioisotope material, such as gaseous tritium. The volume, shape, phosphor material, and radioisotope material are selected for emission of light at a particular wavelength and delivering a particular irradiance on the retina (when implanted in an eyeball). The wavelength is in the range of 400 to 600 nm and the irradiance is substantially 109 to 1011 photons per second per cm2.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: February 22, 2022
    Assignee: California Institute of Technology
    Inventors: Yu-Chong Tai, Colin A. Cook
  • Patent number: 11247074
    Abstract: Disclosed herein are system, method, and computer program product embodiments a 6 degree-of-freedom (6DoF) correction trajectory in order to compensate movement of a treatment target in a patient supported by a patient support end-effector. An embodiment operates by receiving a starting end-effector position, a starting clinical target position, and a target destination position. The target destination position corresponds to a position in space receiving targeted treatment from a treatment delivery device. The embodiment determines a destination end-effector position in 6DoF associated with the end-effector that would cause the target to be positioned on the target destination position. A trajectory is calculated between the starting end-effector position and the destination end-effector position.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: February 15, 2022
    Inventor: Rodney Wiersma
  • Patent number: 11191935
    Abstract: The invention pertains to apparatuses, means and methods to promote uptake of biocompatible fluids into a reservoir of an implantable drug delivery system though a porous membrane. Embodiments of the invention promote fluid uptake by creating a pressure differential between the reservoir of the drug delivery device and the biocompatible fluid outside the device.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: December 7, 2021
    Assignee: NANO PRECISION MEDICAL, INC.
    Inventors: Christian S. Eversull, Stephen A. Leeflang, William G. M. Fischer, Wouter E. Roorda
  • Patent number: 11179143
    Abstract: The present disclosure generally relates to devices, systems, and methods for Fallopian tube diagnostics. In some embodiments a tube may have a distal end, and a balloon may have a first end coupled to the distal end of the tube. The balloon may be disposed in the tube in a first, inverted position, may be movable to a second, everted position, and may be extendable a distance distal of the tube. An extending portion may have a proximal end coupled to a second end of the balloon. The extending portion may be disposed within the balloon in the first inverted position, and may be extendable from the second end of the balloon in the second everted position.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: November 23, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Jesus Magana, David W. Snow, Alan L. Bradley, Christina Christman-Skieller, Surbhi Sama
  • Patent number: 11147618
    Abstract: Systems, such as an electrosurgical unit, and method for use with an active electrode and a plurality of return electrodes are disclosure. An electrosurgical treatment is provided to tissue via the active electrode at a treatment site and a first return electrode of the plurality of return electrodes at the treatment site. An impedance measurement is received or determined of an impedance in the tissue between the active electrode at the treatment site and a second return electrode of the plurality of return electrodes at a site remote from the treatment site.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: October 19, 2021
    Assignee: MEDTRONIC ADVANCED ENERGY LLC
    Inventors: John Gearheart, David Hubelbank, Jesse Smith, Vini Podany
  • Patent number: 10980975
    Abstract: Provided is a system for advancing an article along a path. The system may include a head member; a dispatching member, and an eversion sleeve configured with an inverted portion having a sleeve end configured to be fixed to the dispatching member. The system may also include an everting portion configured for articulating to the head member and an un-inverted portion configured to extend from the everting portion towards the dispatching member, at least partially within the inverted portion.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: April 20, 2021
    Assignee: IBEX TECHNOLOGIES LTD.
    Inventor: Amir Horvitz
  • Patent number: 10981018
    Abstract: A loading apparatus is usable to embed radioactive seeds into carriers, while limiting exposure of the user to radioactive energy from the radioactive seeds. The loading apparatus facilitates accurate positioning of radioactive seeds within a carrier. The illustrated loaders comprise two components, a base and a lid, although in other embodiments the loaders may be separated into additional components.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: April 20, 2021
    Assignee: GT MEDICAL TECHNOLOGIES, INC.
    Inventors: John Baker, David Brachman
  • Patent number: 10945965
    Abstract: The present invention relates to novel nanoparticles which can be advantageously used in the health sector as diagnostic and/or therapeutic agents. Nanoparticles of the invention comprise a metallic material at least partly covered with a hafnium oxide material or embedded therein. When compared to existing products, these nanoparticles offer a remarkable benefit over risk ratio. Specifically, these nanoparticles potentiate the efficiency of known metallic nanoparticles. Indeed, they retain the metal's intrinsic properties and are now in addition safely usable in a mammal, in particular in a human being. The invention also relates to methods for producing said nanoparticles, to compositions containing same, and to uses thereof.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 16, 2021
    Assignee: NANOBIOTIX
    Inventors: Agnes Pottier, Laurent Levy, Marie-Edith Meyre
  • Patent number: 10925641
    Abstract: Instruments, systems and methods are provided for efficient loading, indexing and replacement of cartridges for storing, for example, hair grafts. In addition, an improved urging mechanism for expelling hair grafts from a receptacle of a storage cartridge is provided, as well as a method of its operation. Furthermore, cartridges with a plurality of receptacles comprising slots for loading hair grafts are disclosed.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: February 23, 2021
    Assignee: RESTORATION ROBOTICS, INC.
    Inventor: Clifford A. Oostman, Jr.
  • Patent number: 10888710
    Abstract: A transparent loading apparatus (also referred to herein as a “loader”) may partially or entirely comprise transparent material that allows light to pass through the loader and provides the viewer (whether manual or automated) a view of a radioactive seed, a seed carrier, a loading needle, etc. within the loader. In some embodiments, carrier material (e.g., collagen and/or other biocompatible material) and radioactive seeds (e.g., including a metal shielding and radioactive isotope) may transmit light to different degrees. For example, certain carriers, such as collagen carriers, may be translucent, while seeds may be opaque (or mostly opaque) to light. The systems discussed herein allow a viewer to detect location of a seed within a loader, and even within a carrier, because of these different light transmissivity characteristics.
    Type: Grant
    Filed: November 28, 2017
    Date of Patent: January 12, 2021
    Assignee: GT MEDICAL TECHNOLOGIES, INC.
    Inventors: David Brachman, Emad Youssef, Peter Nakaji, Evan K. Fram
  • Patent number: 10874874
    Abstract: A device for treating the brain includes a light source configured to emit near infrared light. The device also includes a collimator configured to receive the near infrared light emitted by the light emitter. The collimator is further configured to collimate the near infrared light. The device also includes an optic configured to focus collimated light. A reflector of the device is configured to change a direction of the collimated light. The reflector is at a distal end of the device, and the distal end is configured to fit between an upper portion of an eyelid of a patient and an orbital socket of the patient.
    Type: Grant
    Filed: December 31, 2019
    Date of Patent: December 29, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Alexander Samaha, Griffin Cummings, Thomas M. DiMauro, Alexandru Paunescu
  • Patent number: 10850126
    Abstract: A system and methods for adaptive placement of a treatment element include a placement device (134), and a localization system (120) configured to track progress of the placement device such that a position of a treatment element (146, 132) placed by or to be placed by the placement device is stored in memory. A computer system (142) includes a program (104) implemented in computer readable storage media and configured to compute an effect of the treatment element at the position and determine whether a dosage amount has been achieved by the treatment element for treatment of an organ.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: December 1, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Dirk Binnekamp, Luis Felipe Gutierrez, Neil David Glossop, Jochen Kruecker, Shriram Sethuraman
  • Patent number: 10835215
    Abstract: A method for minimally invasive laser ablation of a target tissue within a patient while sparing tissue within a safety zone proximate to the target tissue, comprising: guiding a laser fiber within a patient with a guidance tool; measuring a temperature within the target tissue and the safety zone based on an invasive and a non-invasive thermal sensor; computing a thermal profile in conjunction with a real-time tissue image adapted for guidance of the laser fiber with the guidance tool within the patient; and controlling a laser to deliver energy through the laser fiber, to deliver a minimally therapeutic ablation therapy to the target tissue while ensuring that the safety zone is maintained in a non-ablation condition, based on at least a treatment plan, the measured temperature, and the thermal profile.
    Type: Grant
    Filed: September 11, 2013
    Date of Patent: November 17, 2020
    Assignee: CONVERGENT LIFE SCIENCES, INC.
    Inventors: Dinesh Kumar, Amit Vohra, Daniel S. Sperling
  • Patent number: 10751553
    Abstract: A radiation therapy apparatus capable of improving the accuracy of a dose distribution includes an X-ray generation device that is provided at an arm portion of a rotation gantry, a radiation detector that is insertable into the body of a patient, a dose calculation device, and a feedback control device. An X-ray generated due to collision of an electron beam with a target in the X-ray generation device is applied to an affected part (cancer) of a patient on a bed. The radiation detector which is insertable into the body detects the X-ray applied to the affected part so as to output a photon to obtain a dose rate and a dose based thereon. The feedback control device either controls the X-ray generation device such that the obtained dose becomes a set dose or controls the radiation generation device such that the obtained dose rate becomes a set dose rate.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: August 25, 2020
    Assignee: HITACHI, LTD.
    Inventors: Yuichiro Ueno, Takahiro Tadokoro, Yasushi Nagumo, Katsunori Ueno, Kouichi Okada, Shuichi Hatakeyama
  • Patent number: 10646725
    Abstract: Provided in the present invention is a three-dimensional precise intracavitary radiotherapy method and system for treating tumours, comprising the steps of: (1) lesion three-dimensional quantitative measurement and analysis of three-dimensional scanning image of the lesion cavity; (2) comprehensive analysis according to lesion three-dimensional quantitative measurement results and lesion characteristics to calculate the three-dimensional distribution of lesion radiation dose; and (3) according to the three-dimensional distribution diagram of radiation dose, selecting appropriate radiation sources and radiation dose to make a stent, and performing three-dimensional precise intracavitary radiotherapy. At the same time, also provided by the present invention is a system for achieving the above radiotherapy method.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: May 12, 2020
    Assignee: NANJING RONGSHENG MEDICAL TECHNOLOGY CO., LTD.
    Inventors: Gaojun Teng, Yonghua Dong, Derong Leng, Jinhe Guo, Chunjun Liu, Haidong Zhu
  • Patent number: 10624792
    Abstract: A ventilation device includes a hollow body having a main portion, at least one distal member coupled to a distal end of the main portion and at least one proximal member coupled to a proximal end of the main portion. The at least one distal member is formed of a shape memory material. The hollow body includes a deployed state for maintaining an opening in an anatomical structure and an undeployed state. The shape memory material forms the at least one distal member into a deployed position. The shape memory material is reversibly deformed from the deployed state into the undeployed state such that at least the distal member changes in shape to an undeployed position, while the main portion of the hollow body remains unchanged.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: April 21, 2020
    Assignee: Preceptis Medical, Inc.
    Inventors: Michael K. H. Loushin, Keith J. Leland, Jaydeep Yeshwant Kokate
  • Patent number: 10512531
    Abstract: A filter delivery device for implanting a vessel filter within a blood vessel of a patient's body. The filter delivery device includes a mechanism for preventing hooks and/or legs on a vessel filter from entangling with each other while the vessel filter is loaded within the delivery device. In one variation, the filter delivery device includes a delivery catheter with grooves at the distal end lumen opening. When a vessel filter with radially expanding legs is compressed and inserted into the distal end of the delivery catheter, the hooks on the distal end of the legs are received and separated by the corresponding grooves on the delivery catheter. In another variation, a pusher rod, with a receptacle for receiving the hooks, is positioned within a delivery catheter to prevent the entanglement of the hooks and/or legs of a filter loaded within the delivery catheter.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: December 24, 2019
    Assignee: C. R. BARD, INC.
    Inventors: Alexander W. Tessmer, David G. Spilka, David W. Rauch, Andrzej J. Chanduszko, Robert M. Carr, Jr.
  • Patent number: 10493181
    Abstract: A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: December 3, 2019
    Assignee: Microspherix LLC
    Inventor: Edward J. Kaplan
  • Patent number: 10485583
    Abstract: Methods, apparatuses and systems are described for implanting a plurality of fiducial markers into a tissue. Systems include a needle, a stylet sized to slide within a lumen of the needle, and a multi-stop stylet spacer having stopping features configured to engage with the stylet to stop the distal end of the stylet at one or more predetermined distances from the distal end of the needle. Methods for implanting a plurality of fiducial markers into a tissue are described and include inserting a needle preloaded with fiducial markers into a tissue, adjusting a multi-stop stylet spacer from a safety position to a first deployment position, deploying a first fiducial marker into the tissue, adjusting the stylet spacer from the first deployment position to a second deployment position, and deploying a second fiducial marker into the tissue.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: November 26, 2019
    Assignee: Covidien LP
    Inventors: Eugene Campbell, John O. McWeeney, Brian Tinkham, Stephen J. Tully
  • Patent number: 10403410
    Abstract: The present disclosure relates to a source wire assembly for radiographic applications, particularly for guiding a gamma ray source through a tubular path, such as with a radiographic projector. The source wire assembly includes a core of flexible metal cable, such as, but not limited to, aircraft cable, which may include wires and/or strands which are woven, twisted, helix wound or braided. A distal end of the source wire assembly is securely engaged to a Radioactive source capsule assembly while a proximal end of the source wire assembly is securely engaged to a connector housing for connection to driving equipment, such as, but not limited to, a push-pull operation associated with a radiographic projector, which may include source wire locking and safety mechanisms.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: September 3, 2019
    Assignee: QSA GLOBAL, INC.
    Inventors: Matthew A. Potenza, John H. Crosby, Jr., Steven J. Grenier
  • Patent number: 10342966
    Abstract: A barrel adapter mountable to a syringe barrel includes a barrel tip, a needle assembly, a stylet assembly slidably disposed within a needle lumen of the needle assembly, and a plug within the lumen of the needle. An implant delivery syringe includes a barrel, a plunger assembly, and the barrel adapter. The syringe may include a needle retraction mechanism having a biasing member and an actuable locking arrangement. When the actuable locking arrangement is actuated, the biasing member causes the needle to axially translate over the stylet during retraction to dislodge the plug and cause delivery of an implant to a target location. The plug may be a biodegradable polymer plug such as a water-soluble polymer, PLGA, and/or CARP. The stylet may be retracted following delivery. Methods of assembling implant delivery syringes with drug implants are also provided.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: July 9, 2019
    Assignee: UNL Holdings LLC
    Inventors: Gautam N. Shetty, Aaron M. Weir, Christian P. Brandt, Lou Castagna, Tod H. Brenner
  • Patent number: 10322266
    Abstract: Devices and methods are discussed directed to the use of a low profile laser ablation catheter for use in laser ablation removal of arterial plaque blockages to restore blood flow in the treatment of arteriovenous fistulas. Also discussed are devices and methods directed to packaging, long term storage and sterilization of liquid core ablation catheters.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: June 18, 2019
    Assignee: Ra Medical Systems, Inc.
    Inventors: James B. Laudenslager, Dean S. Irwin
  • Patent number: 10292786
    Abstract: Embodiments include a fiducial deployment system with a handle configured for actuation of same. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. The handle includes an actuation mechanism with a recessible-toothed rack and actuation member(s) configured for incrementally or otherwise controlledly deploying one or more fiducials at a time by advancing a stylet through and/or retracting the body of a slotted needle in which fiducials are disposed with a fiducial protrusion extending into the needle slot, which needle slot also includes retaining structures that do not impede the needle lumen.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: May 21, 2019
    Assignee: Cook Medical Technologies LLC
    Inventors: Michael Clancy, Darach McGrath, Ciaran Toomey, Triona Campbell, Patrick Mulcahy, Fionan Keady
  • Patent number: 10293178
    Abstract: In one embodiment, a verification system for confirming the position of a conduit inserted within a patient may include an elongate control element dimensioned for insertion within the conduit. The control element has a proximal end and a distal end, and a verification element coupled to a distal region. The verification element may be configured to detect the presence of a reference marker associated with the conduit and communicate a signal indicative of the position of the reference marker relative to the verification element. The control element may also be configured to maneuver the verification element along a length of the conduit.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: May 21, 2019
    Assignee: Nucletron Operations B.V.
    Inventors: Frits De Vries, Adriaan Van Appeldoorn
  • Patent number: 10085884
    Abstract: Glaucoma can be treated by implanting an intraocular shunt into the eye. Such procedures can employ various deployment devices, shunts, and implantation techniques.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: October 2, 2018
    Assignee: AQUESYS, INC.
    Inventors: Herbert A. Reitsamer, Guenther Grabner, Christopher Horvath, Laszlo O. Romoda
  • Patent number: 9974565
    Abstract: Instruments, systems and methods are provided for efficient loading, indexing and replacement of cartridges for storing, for example, hair grafts. In addition, an improved urging mechanism for expelling hair grafts from a receptacle of a storage cartridge is provided, as well as a method of its operation. Furthermore, cartridges with a plurality of receptacles comprising slots for loading hair grafts are disclosed.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: May 22, 2018
    Assignee: RESTORATION ROBOTICS, INC.
    Inventor: Clifford A. Oostman, Jr.
  • Patent number: 9884205
    Abstract: Brachytherapy seed insertion and fixation devices and systems to decrease implanted brachytherapy seed migration within tissue and minimize trauma. Component(s) with cavity or opening features are attached to a brachytherapy seed or series of seeds. The cavity or opening features interact with the patient's tissue to fix the seed and component assembly in place and inhibit movement/migration of the seed(s). The cavity or opening features may optionally be filled with an adhesive or other beneficial material. The seed(s) or seed and component assembly may be inserted using a delivery device having a needle through which the seed(s) or assembly are implanted and a stylet extending through the needle to cut tissue and facilitate insertion of the needle. The stylet has a reduced diameter cutting tip to cut a narrow hole in tissue, and a tapered region that stretches the narrow hole to accommodate insertion of the larger diameter needle.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 6, 2018
    Assignee: C. R. Bard, Inc.
    Inventors: John Spittle, Michael W. Drobnik, Christopher D. Drobnik, Mike Krachon
  • Patent number: 9861440
    Abstract: The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for delivering energy to difficult to access tissue regions (e.g. peripheral lung tissues), and/or reducing the amount of undesired heat given off during energy delivery.
    Type: Grant
    Filed: May 3, 2011
    Date of Patent: January 9, 2018
    Assignee: NEUWAVE MEDICAL, INC.
    Inventors: Daniel Warren van der Weide, Fred T. Lee, Jr., Christopher Lee Brace, Richard W. Schefelker, Laura G. King, Mark Thom, Matthew Thiel
  • Patent number: 9844683
    Abstract: A portable device for insertion of radioactive seeds in percutaneous interstitial brachytherapy applications is described. The device includes: an elongated main body in form of a handpiece; a shielded container of radioactive seeds, received within the main body and having a rotating drum suitable, in use, to release one or more radioactive seeds from the container; means for driving the rotating drum, activatable by an operator and based on lever mechanisms and gears; and means for introducing one or more radioactive seeds in a body site of interest, comprising a substantially wire-shaped pusher. The pusher urges the radioactive seed(s) released from the rotating drum through a cannula unit.
    Type: Grant
    Filed: November 28, 2012
    Date of Patent: December 19, 2017
    Inventor: Laura Raus
  • Patent number: 9808372
    Abstract: There is provided a therapeutic instrument, for storing a sheet-type therapeutic substance to which a liquid is delivered, and delivering the stored therapeutic substance to an affected part, including: a nozzle member 23 having an opening 34 on a tip end of a tubular part 31 in which the therapeutic substance can be stored, for charging and discharging the therapeutic substance; and a syringe unit 22 that selectively causes a negative pressure and a positive pressure to act in the tubular part 31 through a hole of a valve member 27, wherein the space 33 of the tubular part 31 is the space for sucking the therapeutic substance into the tubular part 31 together with the liquid by causing the negative pressure in the tubular part 31 by the syringe unit 22 when the therapeutic substance is stored therein, and is the space for pushing out the therapeutic substance to outside of the tubular part 31 together with the liquid by causing the positive pressure to act in the tubular part 31 by the syringe unit 22 when t
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: November 7, 2017
    Assignee: Hoya Corporation
    Inventors: Masanobu Inoue, Kikuo Mitomo, Masako Oooka, Kazuyuki Tokumo
  • Patent number: 9764158
    Abstract: A system for delivery of radiation to a target portion of a native tissue is provided. The system includes a catheter having a main catheter body. The main catheter body includes an outer catheter surface and an inner catheter surface that defines a longitudinally oriented lumen. The lumen extends between longitudinally spaced proximal and distal catheter face surfaces extending laterally between the inner and outer catheter surfaces. A sheath covers at least a portion of the outer catheter surface. The sheath includes a tapered portion protruding substantially longitudinally distally from a portion of the distal catheter face surface. A plurality of tubes extends through the lumen towards the distal catheter face surface. Each tube of the plurality of tubes is configured to selectively guide exposure of a radiation source to the target portion of the native tissue.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: September 19, 2017
    Assignee: The Cleveland Clinic Foundation
    Inventor: John Greskovich, Jr.
  • Patent number: 9743912
    Abstract: An ultrasound calibration phantom comprises a portion including at least one fiducial structure having a selected geometric arrangement; a portion adapted for mechanical coupling of the ultrasound calibration phantom to a transrectal ultrasound (TRUS) stepper; and a guide for at least one surgical instrument, the guide being mechanically coupled to the fiducial structure and/or to the TRUS stepper at a selected pose relative to the fiducial structure. A calibration method uses the calibration phantom and provides automatic, intraoperative calibration of ultrasound imaging systems. The invention is useful in ultrasound-guided clinical procedures.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: August 29, 2017
    Assignee: QUEEN'S UNIVERSITY AT KINGSTON
    Inventors: Gabor Fichtinger, Purang Abolmaesumi, Clif E. Burdette, Thomas Kuiran Chen, Andras Lasso, Tamas Heffter
  • Patent number: 9693851
    Abstract: A filter delivery device for implanting a vessel filter within a blood vessel of a patient's body. The filter delivery device includes a mechanism for preventing hooks and/or legs on a vessel filter from entangling with each other while the vessel filter is loaded within the delivery device. In one variation, the filter delivery device includes a delivery catheter with grooves at the distal end lumen opening. When a vessel filter with radially expanding legs is compressed and inserted into the distal end of the delivery catheter, the hooks on the distal end of the legs are received and separated by the corresponding grooves on the delivery catheter. In another variation, a pusher rod, with a receptacle for receiving the hooks, is positioned within a delivery catheter to prevent the entanglement of the hooks and/or legs of a filter loaded within the delivery catheter.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: July 4, 2017
    Assignee: C.R.BARD, Inc.
    Inventors: Alexander W. Tessmer, David G. Spilka, David W. Rauch, Andrzej J. Chanduszko, Robert M. Carr, Jr.
  • Patent number: 9682252
    Abstract: A stranded brachytherapy product and methods of forming a stranded brachytherapy product. The methods includes the step of applying an adhesive to a carrier containing at least one brachytherapy seed so as to, upon curing of the adhesive, impart substantial rigidity to the carrier. Alternatively, the adhesive may be selectively applied so as to provide a deflectable brachytherapy product.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: June 20, 2017
    Assignee: GENERAL ELECTRIC COMPANY
    Inventors: Kevin Helle, Jay Reed
  • Patent number: 9636402
    Abstract: A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: May 2, 2017
    Assignee: Microspherix LLC
    Inventor: Edward J. Kaplan
  • Patent number: 9586049
    Abstract: A system and method for estimating the current delivered to a patient during voltage-regulated electrical stimulation therapy by an implantable medical device includes calculating a total charge delivered and a peak current delivered and the time at which the peak current was delivered using a proxy for the current delivered to the patient and a component such as a current controlled oscillator, the output of which is proportional to the current proxy together with memory for storing values relating to the output proportional to the current proxy. The stored values also may be used to construct a waveform approximating the current delivered to the patient during a therapy of voltage-regulated stimulation. The system and method may be implemented in an active implantable medical device such as an implantable neurostimulator.
    Type: Grant
    Filed: August 1, 2016
    Date of Patent: March 7, 2017
    Assignee: NeuroPace, Inc.
    Inventor: Stephen T. Archer
  • Patent number: 9555263
    Abstract: An apparatus for supporting a brachytherapy includes at least one radiation device, at least one dose measuring device, and a processing unit. The at least one dose measuring device is configured to be introduced into a target area of an object under treatment which includes at least one target object and that is designed to measure radioactive radiation originating from the at least one radiation device, which is introduced into the target area of the object under treatment, and to provide the measured values by way of a device for transmission to the processing unit.
    Type: Grant
    Filed: August 20, 2013
    Date of Patent: January 31, 2017
    Assignee: SIEMENS HEALTHCARE GmbH
    Inventors: David Groke, Michael Wiets
  • Patent number: 9420995
    Abstract: A robotic system for flexible needle steering under ultrasound imaging. A robot is used to steer the needle along a predetermined curved trajectory by maneuvering the needle base. The needle tip position is detected by an ultrasound sensor and the tracking error of the needle tip from a predetermined needle path is input to a controller which solves the inverse kinematic based on the needle position, and the needle and tissue properties. The control algorithm uses a novel method to detect the elastic properties of the tissue by analyzing tissue motion at the region in front of the needle tip. The inverse kinematic solution may be performed on a model of the needle as a flexible beam having laterally connected virtual springs to simulate lateral forces exerted by the tissue elasticity. The system is able to direct the needle to a target within the tissue while circumventing forbidden regions.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: August 23, 2016
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Zipi Neubach, Moshe Shoham
  • Patent number: 9421396
    Abstract: Brachytherapy delivery devices and buttress elements are described herein, along with methods of assembling the brachytherapy devices and the buttress elements for co-delivery of the brachytherapy delivery devices and buttress elements are described herein.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: August 23, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Stephen D. Cassivi
  • Patent number: 9351691
    Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostcs, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: May 31, 2016
    Assignee: Hampton University
    Inventors: Cynthia E. Keppel, Paul Gueye, Christopher Sinesi
  • Patent number: 9333022
    Abstract: A tool for extracting a pin from a substrate comprises a first lever arm with a body part having a cavity in which the free end of a pin can be received, and a second lever arm which can pivot relative to the first lever arm. A jaw component is provided within the body part which can be actuated from an unlocked position in which a pin within the jaw component can slide freely past the jaw component, and a locked position in which the pin is gripped by engagement of the jaw component with the side wall of the pin, and a support is provided which can slide relative to the body part, in a direction towards the substrate from which the pin is to be extracted. Initial movement of the first lever arm relative to the second lever arm causes the jaw component to be actuated from its unlocked position to its locked position so that an inserted pin is gripped by the jaw component.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: May 10, 2016
    Assignee: DEPUY INTERNATIONAL LIMITED
    Inventors: William Graves, Iain Alexander McMillan, Ray Randle
  • Patent number: 9248311
    Abstract: A flexible, multi-lumen brachytherapy device includes a plurality of loose lumens extend through a hub towards a single point of attachment at a distal rigid section. Because the lumens are attached at only a single distal location, the lumens are free to move axially and rotatably, thereby increasing the overall flexibility of the device to thereby decrease intermittent device movement while increasing patient comfort. A novel keyed stylet can be selectively inserted to increase the rigidity of the device as needed. The ability to dynamically modify the rigidity of the brachytherapy device provides a comprehensive brachytherapy solution that satisfies concerns of the patient, the surgeon and the radiologists.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: February 2, 2016
    Assignee: Hologic, Inc.
    Inventor: John Damarati
  • Patent number: 9233259
    Abstract: Applicators for HDR brachytherapy for topical skin treatment which employ multiple channels for radioisotope sources, oriented by the applicator generally parallel to each other and to a desired treatment area skin surface. These applicators provide good radiation exposure uniformity. Filtration of undesirable low energy radiation may be employed using an attached filter element. The applicators are particularly adapted for the treatment of squamous and basal cell skin cancers or other skin lesions. The applicators may provide two or more source guides in various sizes and shapes are described.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: January 12, 2016
    Inventor: Hesham E. Gayar
  • Patent number: 9042964
    Abstract: Embodiments include a fiducial deployment system and method for use thereof. A fiducial may include one or more protuberances configured to engage one or more slots in a needle of the system. The needle may be configured to deliver a plurality of fiducials to a target location in serial fashion, one at a time. In certain embodiments, echogenic placement of fiducials may present certain advantages.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: May 26, 2015
    Assignee: Cook Medical Technologies LLC
    Inventors: Richard W. Ducharme, Vihar C. Surti
  • Patent number: 9028390
    Abstract: An apparatus and method for in vivo and ex vivo control, detection and measurement of radiation in therapy, diagnostics, and related applications accomplished through scintillating fiber detection. One example includes scintillating fibers placed along a delivery guide such as a catheter for measuring applied radiation levels during radiotherapy treatments, sensing locations of a radiation source, or providing feedback of sensed radiation. Another option is to place the fibers into a positioning device such as a balloon, or otherwise in the field of the radiation delivery. The scintillating fibers provide light output levels correlating to the levels of radiation striking the fibers and comparative measurement between fibers can be used for more extensive dose mapping. Adjustments to a radiation treatment may be made as needed based on actual and measured applied dosages as determined by the fiber detectors. Characteristics of a radiation source may also be measured using scintillating materials.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: May 12, 2015
    Assignee: Hampton University
    Inventors: Cynthia E. Keppel, Paul Gueye, Christopher Sinesi
  • Publication number: 20150119628
    Abstract: The invention relates to a brachytherapy apparatus (1) for applying a brachytherapy to a living object. The brachytherapy apparatus comprises a planning unit (14) for determining a placing plan defining placing positions and placing times for one or several radiation sources within the living object and close to a target region. The placing plan is determined such that the placing times are within a treatment time window determined by a treatment time window determination unit (13), wherein within the treatment time window a change of a spatial parameter of the living object caused by swelling is minimized. An adverse influence on the brachytherapy due to swelling can thereby be minimized, which improves the quality of the brachytherapy.
    Type: Application
    Filed: May 3, 2013
    Publication date: April 30, 2015
    Inventors: Shyam Bharat, Christopher Stephen Hall, Cynthia Ming-Fu Kung, Jochen Kruecker
  • Publication number: 20150105606
    Abstract: The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm.
    Type: Application
    Filed: April 23, 2014
    Publication date: April 16, 2015
    Inventors: Johann Kindlein, Dimos Baltas, Georgios Sakas, Frans Kuipers, Hans Martin Schot
  • Patent number: 8974364
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: March 10, 2015
    Assignee: GammaTile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 8944984
    Abstract: There is provided herein a brachytherapy delivery system for the internal delivery and positioning of therapeutic agent, most particularly, a discrete radiation emitting particulate, within or in proximity to a vertebral or other bony tumor. The system comprises an elongated bone cannula having a proximal and a distal end, the distal end being suitable for disposition within bone. The bone cannula further comprises a bore disposed longitudinally therethrough suitable to axially and slidably receive an elongated and cannulated therapy delivery apparatus through which the therapeutic agent is delivered.
    Type: Grant
    Filed: March 11, 2009
    Date of Patent: February 3, 2015
    Inventors: Kevin Armstrong, Thomas Chen
  • Patent number: 8939881
    Abstract: A device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present invention relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 27, 2015
    Assignee: Gammatile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas