Seeds Patents (Class 600/8)
  • Patent number: 10714224
    Abstract: The invention provides a method of preparing irradiation targets for radioisotope production in instrumentation tubes of a nuclear power reactor, the method comprising the steps of: providing a powder consisting of an oxide of a rare earth metal having a purity of greater than 99% and, optionally, an organic binder; pelletizing the powder and optionally the organic binder to form a substantially spherical green body having a diameter of from between 1 to 10 mm; and sintering the spherical green body in solid phase at a temperature of at least 70 percent of a solidus temperature of the rare earth metal oxide powder and for a time sufficient to form a round sintered rare earth metal oxide target having a sintered density of at least 80 percent of the theoretical density.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: July 14, 2020
    Assignee: FRAMATOME GMBH
    Inventors: Beatrice Schuster, Wolfgang Schmid
  • Patent number: 10589126
    Abstract: The invention provides a method for locating radioactive material implanted in a living body, the method having the steps of implanting a stent into the body, the stent containing the radioactive material; imaging the body to determine a first position of the stent relative to remote points on the body; determining a second position of the stent at a second time later than the time of the implanting step; and measuring the distance between said first position and said second position. Also provided is a system for determining movement of a radiation source implanted in a living body, the device having a radiographic film overlaying a region of the body so as to oppose the radiation source, whereby the film is positioned relative to a reference point on the body; a grid disposed between the film and the body; and a radio-opaque substrate overlaying the film.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: March 17, 2020
    Inventor: Arnold M. Herskovic
  • Patent number: 10548996
    Abstract: Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be conjugated to a high molecular weight molecule, which may be encapsulated in a microparticle, where the microparticle is then dispersed within a hydrogel. The radioactive hydrogel may prevent leakage of the radioisotope to provide radiotherapy to a surgical margin while minimizing damage to surrounding normal tissue.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 4, 2020
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Abdel Kareem Azab, Pilar de la Puente, Feda Azab
  • Patent number: 10441689
    Abstract: A method for manufacturing a bioactive implant including the steps of (a) forming a mixture of an bioactive agent and a setting agent capable of transitioning from a flowable state to a rigid state; (b) converting the mixture into a flowable state; and (c) transitioning the mixture into a solid state in a shape of the implant.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: October 15, 2019
    Assignee: Louisiana Tech Research Corporation
    Inventors: Jeffery Adam Weisman, Connor Nicholson, David Mills
  • Patent number: 10293553
    Abstract: A surgical buttress for use in a surgical stapling apparatus is provided. The surgical buttress includes an elongate rectangular body portion defining a width; a nose portion integrally formed with and extending from a distal end of the body portion, the nose portion defining a width that is less than the width of the body portion; a neck portion integrally formed with and extending from a distal end of the nose portion, the neck portion defining a width; a head portion integrally formed with and connected to a distal end of the neck portion, the head portion defining a width; and a tail portion integrally formed with and extending from a proximal end of the body portion, the tail portion defining a width that is less that the width of the body portion. The surgical buttress is formed from a material having filaments. The surgical buttress include radioactive material.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: May 21, 2019
    Assignee: Covidien LP
    Inventors: David Racenet, Gerald Hodgkinson, William Powers
  • Patent number: 10213581
    Abstract: Various devices, systems, and methodologies are disclosed for delivering a chemical agent to tissue, e.g., for delivering an anti-restenotic agent to tissue comprising a wall of a blood vessel. In one embodiment of the disclosure, a delivery member is disclosed comprising a body that includes a plurality of discrete, separable sections, wherein each section includes a housing defining an internal cavity, and a penetrating member that extends from the housing.
    Type: Grant
    Filed: January 24, 2014
    Date of Patent: February 26, 2019
    Assignee: Covidien LP
    Inventors: Thomas McPeak, William Whealon
  • Patent number: 10071173
    Abstract: Composition in the form of a shaped device, for use as a fiducial marker in tissues in the animal body, in radiotherapy and/or radiosurgery, characterized in that it comprises:—a core consisting of a colloidal dispersion of metal nanoparticles and/or oxides or metal salts having X-ray-contrast properties, where said nanoparticles are stabilized with surfactants, polymers or capping agents in a liquid vehicle, and—a polymeric casing that encapsulates the core, said device having a minimum size of not less than 500 microns and a maximum size not greater than 3000 microns.
    Type: Grant
    Filed: April 5, 2016
    Date of Patent: September 11, 2018
    Assignee: FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA
    Inventors: Gabriele Maiorano, Elisa Mele, Athanasia Athanasiou, Pier Paolo Pompa
  • Patent number: 9943273
    Abstract: A method of preparing a radioactive material to serve as a radiation source for an intra-lumen imaging capsule, including, receiving a radioactive substance having grains in powder form, forming a solid pellet wherein the grains of the radioactive substance are dispersed homogenously in the pellet and surrounded by less dense materials having lower radiation absorption.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: April 17, 2018
    Assignee: CHECK-CAP LTD.
    Inventors: Yoav Kimchy, Salah Hasoon
  • Patent number: 9895549
    Abstract: Disclosed herein are methods of delivering drugs to a subject in a controlled release fashion by administering a magneto-electric nanoparticle having ionic bonds to a drug then applying a magnetic field to weaken the ionic bonds and release the drug.
    Type: Grant
    Filed: November 6, 2013
    Date of Patent: February 20, 2018
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Sakhrat Khizroev, Madhavan P. N. Nair, Ping Liang, Carolyn Runowicz, Rakesh Guduru
  • Patent number: 9895556
    Abstract: A system and method include a shape sensing enabled device (116) having at least one optical fiber (118). A source positioning module (124) is configured to receive optical signals from the at least one optical fiber within a structure and interpret the optical signals to provide motion information of treatment sources within the device. A dose determination module (130) is configured to provide one or more temporal bins representing a total treatment time. For each temporal bin, the dose determination module is configured to determine a dose received by a target area to be treated using the motion information of the treatment sources. The dose determination module is further configured to combine the dose received by the target area for each of the one or more temporal bins to determine a total dose received by the target area.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: February 20, 2018
    Assignee: Koninklijke Philips N.V.
    Inventor: Shyam Bharat
  • Patent number: 9788408
    Abstract: The invention relates to nuclear technology, and to irradiation targets and their preparation. One embodiment of the present invention includes a method for preparation of a target containing intermetallic composition of antimony Ti—Sb, Al—Sb, Cu—Sb, or Ni—Sb in order to produce radionuclides (e.g., tin—117m) with a beam of accelerated particles. The intermetallic compounds of antimony can be welded by means of diffusion welding to a copper backing cooled during irradiation on the beam of accelerated particles. Another target can be encapsulated into a shell made of metallic niobium, stainless steel, nickel or titanium cooled outside by water during irradiation. Titanium shell can be plated outside by nickel to avoid interaction with the cooling water.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: October 10, 2017
    Inventors: Boris L. Zhuikov, Nicolai A. Konyakhin, Vladimir M. Kokhanyuk, Suresh C. Srivastava
  • Patent number: 9682246
    Abstract: A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: June 20, 2017
    Assignee: The University of Toledo
    Inventors: E. Ishmael Parsai, John J. Feldmeier
  • Patent number: 9545525
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: May 4, 2015
    Date of Patent: January 17, 2017
    Assignee: GammaTile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 9198989
    Abstract: Methods are described for treating a target tissue with a radioisotope. Some methods include determining a distance between a target tissue and a surface of a matrix material to be positioned adjacent the target tissue and, based on the determined distance, determining an activity to be mixed with the matrix material to obtain a desired activity concentration. Some methods further include mixing the radioisotope with the matrix material. In some embodiments, the matrix material is a bone cement, and the target tissue is a tumor in a bone. The radioisotope may be a beta-emitting radioisotope mixed in the cement at a concentration to form a radioactive cement.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: December 1, 2015
    Assignee: The Regents of the University of California
    Inventors: Joyce H. Keyak, Tadashi Kaneko, Harry B. Skinner, Varun Sehgal
  • Publication number: 20150148669
    Abstract: The present invention relates to an implantable medical appliance with means of migration prevention, which is either coated with a biocompatible polymer or coated with a biocompatible adhesive, or injected with a biocompatible adhesive after the insertion of the implantable medical appliance into a living body, or equipped with a foldable anchor. The implantable medical appliance of the present invention characterized by the means equipped on the surface of the same to prevent intratissue migration can be effectively used for such implantable medical appliance as a sealed source used for brachytherapy, a fiducial marker used for increasing accuracy of IGRT, a clip for surgical operation, and a transponder for the generation of radio frequency, etc, since the migration of the medical appliance is prevented after the insertion.
    Type: Application
    Filed: December 22, 2014
    Publication date: May 28, 2015
    Inventors: Sung-Joon YE, Young Bin Choy, Hyun Seok Lee, Sung Yoon Choi, Won Seok Lee
  • Patent number: 9022915
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: May 5, 2015
    Assignee: GammaTile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Publication number: 20150065784
    Abstract: An applicator device is provided including a connecting unit. The connecting unit includes a first connector coupled to a first colpostat and a second connector coupled to a second colpostat. The first connector includes a first contact portion and a body portion, the first contact portion being immovably fixed to the body portion. The second connector includes a second contact portion and a third contact portion, the second contact portion being configured to contact and pivotally engage the first contact portion. The first connector further includes a fourth contact portion configured to contact the third contact portion. The second contact portion and the third contact portion are disposed between the first contact portion and the fourth contact portion, and the first contact portion are disposed in closer proximity to a point of delivery of a radiation source than the second, third, or fourth contact portions.
    Type: Application
    Filed: July 17, 2014
    Publication date: March 5, 2015
    Inventors: Spencer J. Fillmore, Christopher M. Lee
  • Publication number: 20150057487
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Publication number: 20150031935
    Abstract: An instrument used for brachytherapy delivery in the treatment of cancer by radiation therapy including a handle having first and second handle actuators; an end effector; and an instrument shaft that connects the handle with the end effector. The end effector has first and second adjacent disposed staple cartridges that each retain a set of staples. The first mechanism is for holding standard staples in a first array, and dispensing the standard staples under control of the corresponding first handle actuator. The second mechanism is for holding radioactive source staples in a second array, and dispensing said radioactive source staples under control of the corresponding second handle actuator. The actuating device is removably attachable to an actuator arm on a proximal end. A staple applicator cartridge holder is attached to the actuator arm on a distal end. The staple applicator cartridge is mountable in the holder and having a plurality of slots for mounting of radioactive source staples therein.
    Type: Application
    Filed: May 9, 2012
    Publication date: January 29, 2015
    Inventors: David E. Wazer, Thomas A. DiPetrillo, John J. Munro, Matthew Hollows, Kevin Schehr, Krissie K. Zambrano
  • Patent number: 8939881
    Abstract: A device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present invention relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: January 27, 2015
    Assignee: Gammatile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Publication number: 20140377336
    Abstract: The use of dianhydrogalactitol provides a novel therapeutic modality for the treatment of glioblastoma multiforme and medulloblastoma. Dianhydrogalactitol acts as an alkylating agent on DNA that creates N7 methylation. Dianhydrogalactitol is effective in suppressing the growth of cancer stem cells and is active against tumors that are refractory to temozolomide; the drug acts independently of the MGMT repair mechanism.
    Type: Application
    Filed: January 22, 2013
    Publication date: December 25, 2014
    Inventors: Dennis Brown, Jeffrey Bacha, Sandra Dunn
  • Publication number: 20140378739
    Abstract: Devices and techniques for permanent application of radioactive sources in the field of brachytherapy are described. In an embodiment, an implantable device for radiation therapy of pathological tissues directed toward the administration of radiation to tissue adjacent a cavity wall or surgical excision. The device may include an insertable member, such as a substantially cylindrical member, having at least two ends, a central section positioned between the ends, and a fixation element to retain the implantable device implanted in tissue at a desired position. The device may further include a radioactive source at least partially positioned within the insertable member and that is disposed to deliver radiation to a desired area.
    Type: Application
    Filed: June 18, 2014
    Publication date: December 25, 2014
    Inventors: John J. Munro, III, Matthew R. Hollows
  • Patent number: 8915834
    Abstract: A spacer for use in brachytherapy, and radiotherapy, is formed of an encapsulating material in a generally cylindrical or elongated shape. Regions are formed within the spacer and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or other substances to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: December 23, 2014
    Assignee: Eckert & Ziegler Bebig S.A.
    Inventors: Gary A. Lamoureux, Warren Johnston, Lino Costantini
  • Publication number: 20140357977
    Abstract: In order to increase the accuracy and speed of catheter reconstruction in surgical procedures such as an HDR prostate implant procedure, an automatic tracking system is provided preferably using an electromagnetic tracking device. The system uses a transmitter with a sensor used for catheter position. Due to substantial interference in the electromagnetic field from the surgical table, implant stepper/stabilizer etc, a calibration algorithm using a scattered data interpolation scheme is implemented to correct tracking location errors. The invention includes methods and systems used to carry out the methods.
    Type: Application
    Filed: May 9, 2012
    Publication date: December 4, 2014
    Applicant: William Beaumont Hospital
    Inventor: Jun Zhou
  • Publication number: 20140350325
    Abstract: An afterloading device for effectuating a brachytherapy treatment, comprising a first elongated flexible transport element, arranged to maneuver a radiation source between a storage position inside the afterloading device and a treatment position outside the afterloading device, the afterloading device further comprising a second elongated flexible transport element, having at least one transducer, the second transport element being arranged to move the at least one transducer between a first transducer position and a second transducer position.
    Type: Application
    Filed: May 21, 2014
    Publication date: November 27, 2014
    Applicant: Nucletron Operations B.V.
    Inventors: Adriaan VAN APPELDOORN, Jeroen SCHUURMAN, Martin VAN BEEK, Finn SOLLEN, Johan HENNING, Arie Luite VISSCHER
  • Publication number: 20140350326
    Abstract: A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Darrell R. Fisher, You Han Bae, Zhonggao Gao
  • Publication number: 20140343348
    Abstract: Methods and devices for diagnosing, monitoring, and/or treating tissue through an opening or port through an airway wall. A passageway is created extending from the airway to the target tissue. The passageway provides local access to the target tissue for treatment instruments and for delivering agents.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 20, 2014
    Applicant: BRONCUS MEDICAL INC.
    Inventors: Gary S. KAPLAN, Michael D. LAUFER, Thomas M. KEAST, Cary COLE, Henky WIBOWO, Edmund J. ROSCHAK
  • Patent number: 8878464
    Abstract: A laser accelerator driven electronic brachytherapy system, device, and method for particle based treatment of a tumor or other human diseases and conditions.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: November 4, 2014
    Assignees: Varian Medical Systems Inc., The Regents of the University of California
    Inventors: James E. Clayton, Paul A. Lovoi, Wim Leemans
  • Patent number: 8876684
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: November 4, 2014
    Assignee: Gammatile LLC
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Publication number: 20140323795
    Abstract: A brachytherapy needle holder includes a needle card holding one or more brachytherapy needles preloaded with one or more brachytherapy seeds, wherein the needle holder includes a scored needle card shield that may be bent at the score so that the needle card may stand up on its own, providing one-handed access. A brachytherapy needle holder includes a needle card holding one or more brachytherapy needles preloaded with one or more brachytherapy seeds, wherein the needle holder further includes a needle card shield that provides one or more of rigidity and shielding from radiation for one or more of a physician and other medical personnel.
    Type: Application
    Filed: April 28, 2014
    Publication date: October 30, 2014
    Applicant: Bard Brachytherapy, Inc.
    Inventors: Christopher D. Drobnik, John Spittle, Mike Krachon, Russ Riescher
  • Publication number: 20140316187
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Publication number: 20140303423
    Abstract: The invention provides for a medical apparatus (200, 300, 400) comprising: a magnetic resonance imaging system (202), a display (270), a processor (228), and a memory (234) for storing instructions for the processor. The instructions causes the processor to receive a brachytherapy treatment plan (240), acquire (100) planning magnetic resonance data (244), calculate (102) a catheter placement positions (246, 900, 902) and a catheter control commands (248) the brachytherapy catheters.
    Type: Application
    Filed: September 25, 2012
    Publication date: October 9, 2014
    Applicant: KONINKLIJKE PHILIPS N.V.
    Inventors: Thomas Erik Amthor, Falk Uhlemann, Sascha Krueger, Steffen Weiss, Ronaldus Frederik Johannes Holthuizen, Daniel Wirtz, Peter Kokenm
  • Publication number: 20140296612
    Abstract: A lightweight, portable, interchangeable and effective overlay plate that will increase the efficiency of brachytherapy radiation treatment and reduce the duration of the radiation exposure during the radioactive seed insertion and positioning in brachytherapy. The overlay plate has a limited number of apertures specific to the treatment of a particular patient and is attached to the matrix used to position and guide the needles with the radioactive seeds. The apertures of the overlay plate may further be truncated-cone-shaped, with the narrow ends aligned with corresponding apertures in the matrix and the flared ends facing the user. The overlay plate minimizes the radiation exposure as much as reasonably possible because any amount of radiation exposure carries a risk to the exposed individual, and the overlay plate may also be manufactured from radiation-protective material to further minimize the radiation exposure.
    Type: Application
    Filed: July 12, 2013
    Publication date: October 2, 2014
    Inventor: David Schwartz
  • Publication number: 20140296611
    Abstract: A lightweight, portable, interchangeable and effective shield that will protect from radiation during the radioactive seed insertion and positioning in brachytherapy. The shield is attached to the matrix used to position and guide the needles with the radioactive seeds. The shield minimizes the radiation exposure as much as reasonably possible because any amount of radiation exposure carries a risk to the exposed individual.
    Type: Application
    Filed: April 30, 2013
    Publication date: October 2, 2014
    Inventor: David Schwartz
  • Publication number: 20140275715
    Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Inventors: David Brachman, Peter Nakaji, Heyoung McBride, Emad Youssef, Theresa Thomas
  • Patent number: 8834340
    Abstract: A radioactive seed and method for making a radioactive seed with selective magnetic imaging characteristics are provided. The seed includes a housing which may include a metal shell for at least partially enclosing a radioactive material. The shell encloses a rod having a nickel layer with a phosphorous content, wherein the phosphorous content includes a level of phosphorous sufficient, when the seed is implanted in tissue, to provide a magnetic resonance image of the seed while substantially eliminating gross artifacts in the magnetic resonance image.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: September 16, 2014
    Assignee: C. R. Bard, Inc.
    Inventors: Christopher D. Drobnik, Michael W. Drobnik
  • Patent number: 8827884
    Abstract: An oncology therapy method comprises implanting a radioactive seed (10, 20, 30, 40, 50) in an oncology subject (S). In some embodiments the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a biodegradable host (14, 24, 25, 44) configured to biodegrade over a therapy time period when implanted in the oncology subject. In some embodiments the radioactive seed is implanted in soft tissue of an oncology subject (S), and the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a host material (14, 24, 25, 44) having softness comparable with or softer than the soft tissue into which the radioactive seed is implanted.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: September 9, 2014
    Assignee: Koninklijke Philips N.V.
    Inventors: Carolina Ribbing, Michael Overdick
  • Publication number: 20140249406
    Abstract: Compensator-based brachytherapy (CBT) for treatment of cancerous tumors or other pathologic tissues. CBT permits, in one aspect, increased dosage conformity for non-radially symmetric tumors by utilizing a device that can shield radiation emanated from an electronic brachytherapy (BT) source or non-electronic BT source. The device can comprise, in one aspect, a radiation compensator having a treated surface that comprises a position-dependent thickness based at least on a radiation therapy plan specific to a patient and geometry of a patient region to be treated. In an additional or alternative aspect, the device can comprise a source of radiation movably inserted into an enclosure coupled to the radiation compensator. As part of CBT, in one implementation, the radiation source can reside at a plurality of locations within the radiator compensator during a respective plurality of dwell times based on the radiation therapy plan.
    Type: Application
    Filed: November 5, 2013
    Publication date: September 4, 2014
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Ryan Flynn, Yusung Kim, Xing Li, Kee-Ho Yuen
  • Patent number: 8821364
    Abstract: A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: September 2, 2014
    Assignees: Battelle Memorial Institute, University of Utah Research Foundation
    Inventors: Darrell R. Fisher, You Han Bae, Zhonggao Gao
  • Patent number: 8795146
    Abstract: A brachytherapy implant includes a plurality of protrusions to reduce a tendency of the implant to migrate and rotate within a patient's body after implantation. Embodiments of the present invention are directed to spacers that resist migration and rotation. This abstract is not intended to be a complete description of the invention.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: August 5, 2014
    Assignee: Eckert & Ziegler Bebig S.A.
    Inventors: Gary A. Lamoureux, James Matons, Warren W. Johnston, Matthew Bouffard, Warren Rice
  • Patent number: 8798716
    Abstract: In part, the invention relates to fiduciary markers suitable for affixing to a patient that are detectable with respect an imaging modality such as MRI and methods of making the same. The markers include a paramagnetic material disposed therein that generates a distinguishable signal relative to a patient or other biological sample of interest during an imaging data collection session. Further, the markers demonstrate desirable signal to noise ratios across two or more MRI data collection procedures in one embodiment. The length of the markers is also adjustable by, for example, cutting or tearing a substrate upon which a substantially fluid-free region straddles a specified separation position on the substrate.
    Type: Grant
    Filed: November 3, 2011
    Date of Patent: August 5, 2014
    Assignee: Solstice Corporation
    Inventors: Danforth S. DeSena, Peter Caravan
  • Patent number: 8790235
    Abstract: A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: July 29, 2014
    Assignee: Eckert & Ziegler Debig S.A.
    Inventors: Gary A. Lamoureux, James Matons, Warren Johnston, Matthew Bouffard, Warren Rice
  • Publication number: 20140206926
    Abstract: Methods and systems are disclosed for radiation therapy treatment planning. In one embodiment, a radiation therapy treatment planning method is disclosed for adjusting a dose distribution of a target anatomical portion. The method includes displaying an image of an implanted volume and a set of catheters displayed as implanted in the anatomical portion. The method also includes determining to adjust the dose distribution to the implanted volume for delivering via the catheters. The method also includes receiving, at a processor, a selection of a dose distribution parameter affecting the strength of the dose distribution and adjusting, based on the received parameter, a dwell weight of the radiation dose at each dose position in the set of catheters, wherein the adjusted dwell weight adjusts the dose distribution relative to a center region of the implanted volume for moving the distribution to or from an outer circumference of the target anatomical portion.
    Type: Application
    Filed: January 18, 2013
    Publication date: July 24, 2014
    Inventor: Robert van der LAARSE
  • Patent number: 8771162
    Abstract: A spacer for use in brachytherapy, and radiotherapy, is formed of an encapsulating material in a generally cylindrical or elongated shape. Regions are formed within the spacer and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or any other substances to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: July 8, 2014
    Assignee: Eckert & Ziegler Bebig S. A.
    Inventors: Gary A. Lamoureux, Warren Johnston, Lino Costantini
  • Publication number: 20140179979
    Abstract: The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.
    Type: Application
    Filed: June 21, 2012
    Publication date: June 26, 2014
    Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDA
    Inventors: Steven E. Finkelstein, Matthew C. Biagioli, Mayer N. Fishman
  • Patent number: 8702579
    Abstract: A needle holder device for treating the prostate, involving a series of steps of inserting a needle into the prostate, has a rectal probe for ultrasonic 3D imaging and a computer for processing the image acquired by the probe and for computing the position of the needle relative to the prostate. The computer is controlled so as to periodically output information on the movement of the prostate after each of the insertion steps in order to validate the insertion parameters relative to a treatment schedule and, if need be, modifying the insertion parameters relative to the schedule in the event the movement is greater than a threshold value.
    Type: Grant
    Filed: August 27, 2010
    Date of Patent: April 22, 2014
    Assignees: Koelis, Universite Joseph Fournier
    Inventors: Michael Bauman, Nikolai Hungr, Antoine Leroy, Jocelyne Troccaz, Vincent Daanen
  • Patent number: 8696540
    Abstract: According to one general aspect there is a needle package apparatus that comprises a top portion and a bottom portion; a plurality of needle slots exact distance apart that allows to place a plurality of needles that contain radioactive seeds; a cylindrical coil that is inserted to the plurality of needle slots to hold said plurality of needles, wherein said cylindrical coil prevents the leakage of the radiation from the radioactive seeds; a set of hinges located at the end of said needle package within the outer most said plurality of needle slots; wherein the hinges can be bend to change the angle of said top portion of said needle package by a medical personnel to create a stand; and a single end enclosure located at the distal end of said cylindrical coil to provide an enclosed cylinder.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: April 15, 2014
    Assignee: Best Medical International, Inc.
    Inventors: Rohit Mehta, Rashmi Amin
  • Patent number: 8641592
    Abstract: A method and device for image guided dynamic radiation treatment of prostate cancer and other pelvic lesions including: 1) a unique fan geometry of radiation sources; 2) a special collimation method and apparatus to sculpt the radiation borders; 3) an integrated three-dimensional imager and a special tissue interface imaging system to locate and track critical boundaries in real-time; 4) a dynamic patient support system, which is shared by the said imager and the irradiation system; and 5) motorized custom shielding filters to further protect neighboring normal tissues such as the kidneys and femoral heads. The fan geometry utilizes a plural number of radiation sources arranged specifically for irradiating tumors in the human pelvis while not harming critical structures, and the collimation sculpts the radiation borders using motorized shields for different sensitive structures.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: February 4, 2014
    Inventor: Xinsheng Yu
  • Publication number: 20140018607
    Abstract: A method for generating a treatment plan for therapy comprising obtaining image data representing a tissue, determining a therapy dose map comprising dose values for a plurality of dose points based on the image data, forming a desired dose value vector comprising the dose values for the plurality of dose points, determining a one or more potential therapy locations based on the image data, determining a therapy dose map equation for each of the plurality of dose points based on the one or more potential therapy locations, forming a matrix based on the therapy dose map equations for the each dose points, determining an inverse of the matrix and determining the treatment plan by multiplying the desired dose value vector by the inverse of the matrix.
    Type: Application
    Filed: December 17, 2012
    Publication date: January 16, 2014
    Applicant: HOLOGIC, INC.
    Inventor: HOLOGIC, INC.
  • Publication number: 20130338423
    Abstract: A device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present invention relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.
    Type: Application
    Filed: April 30, 2012
    Publication date: December 19, 2013
    Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas