Abstract: The present invention relates to a matrix material comprising a pharmaceutical composition such as a matrix material with a pharmaceutical composition printed on the surface. In one embodiment the pharmaceutical composition comprises thrombin. The invention further describes a method for making the matrix material with a pharmaceutical composition printed on the surface. In one specific embodiment the invention also relates to the use of said matrix material for promotion of hemostasis and/or wound healing. The invention also relates to a kit-of-parts comprising a matrix with a pharmaceutical composition and a container with a peelable lid.

Abstract: An adhesive for medical patches or for transdermal therapeutic systems which contains a component or a combination of at least two components, such as (a) polyvinyl alcohols, (b) cellulose derivatives, (c) polyethers, (d) acid anhydrides and their acids and salts, as well as (e) non-pressure-sensitive adhesive polyacrylates. The adhesive has a tackiness which is activated and/or increased by contact with moisture or by absorption of moisture.

Abstract: Two “U-Shaped” or “V-Shaped” or slit plasters/adhesive tape to be placed opposite one another over a pad placed around the extruding object from the skin to completely surround the extruding object and adhere the pad securely at the exit site. The pad is placed around the extruding object at the exit site. The adhesive tape is adhered to affix the pad to the skin so that the extruding member reaches the bottom of the “U” or the “V” or the slit as closely as possible. The adhesive tape is placed opposite the tape to affix the rest of the pad to the skin, so that the extruding member touches the bottom of the “U” or the “V” or the slit of this adhesive as closely as possible.

Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.

Abstract: An adhesive composition including an adhesive component and an enzyme inhibiting component for use in ostomy and wound care applications. The enzyme inhibitors are derived from tubers, such as potatoes. In ostomy, the adhesive composition helps to secure the collection bag or pouch to the skin. In wound care application, the adhesive composition secures the wound dressing to the skin. The adhesive composition also may be used to couple two or more ostomy or wound care components together.

Abstract: Methods for producing biocompatible compositions are provided. The biocompatible compositions include an isocyanate-functional polyurethane prepolymer in combination with a foam control agent. The foam control agent decreases the formation of bubbles and/or foam in the biocompatible composition, thereby enhancing the physical properties of the biocompatible composition. The presence of the foam control agent does not compromise the strength of the biocompatible composition. The compositions prepared by the methods of the present disclosure may be used as adhesives or sealants for medical/surgical uses.

Abstract: A medical dressing comprising a backing layer and a self-supporting substrate. The backing layers form a perimeter around the self supporting substrate and hold the self supporting substrate in place on a wound.

Abstract: A bandage for covering an affected area of the skin is provided. The bandage including: a first bandage having an adhesive for adhering to the skin and an opening for exposing the affected area; a second bandage for covering the opening; and a releasable attachment system for releasably securing the second bandage to the first bandage to cover the opening. Also provided is a swab including: a tubular body having a conduit and a breakable wall portion disposed in the conduit; a fluid disposed in the conduit; and a cotton swab disposed at an end of the tubular body; wherein bending of the tubular body breaks the breakable wall portion allowing the fluid to flow into the cotton swab. Still further provided is a cotton product including: a cotton body; and a breakable capsule disposed in the body, the breakable capsule having a cavity filled with a fluid.

Abstract: Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.

Abstract: A medical dressing comprising absorbent polyurethane foam wherein the foam comprises an antimicrobial agent, which can be released from the foam by the action of water. The antimicrobial agent is also used as a control of the resilience of the foam. The antimicrobial agent can be poly(hexamethylene biguanide)hydrochloride, also named PHMB or polyhexanide.

Abstract: An apparatus for promoting the healing of a wound includes a pressure-sensitive adhesive disposed around a periphery of the wound, and a membrane layer in positioned over the wound with a lower surface in contact with the pressure-sensitive adhesive to form a substantially fluid-tight seal to define reservoir over the wound in which a negative pressure may be maintained. In fluid communication with the reservoir is a vacuum source suitable for providing an appropriate negative pressure to the reservoir to stimulate healing of the wound. A resilient member is placed over an upper surface of the membrane layer, and a compression member is configured to apply a compressive force to the resilient member. The resilient member distributes the compressive force to the membrane layer to reinforce the fluid tight-seal.

Abstract: A variety of article and systems including wound care systems, methods for making the wound care systems, bactericidal, and methods for treating wounds using these systems are disclosed. The wound care systems may include a first material comprising one or more fibers or porous media. The one or more fibers or porous media may be coated with a second material that is capable of inhibiting the growth of bacteria and killing the bacteria to render the wound care system sterile, increasing the absorbency of the first material, or both upon exposure to light. The first material may be cotton, or any suitable fibrous material, the second material may be TiO2, and the light may be UV or visible light. A variety of methods including ALD may be used to coat the first material.

Abstract: A chitosan biomaterial is frozen in aqueous solution to form a frozen chitosan structure from which water is removed by a prescribed freeze-drying process to form a sponge-like chitosan structure having a thickness and a density. The sponge-like chitosan structure is compressed by application of heat and pressure to reduce the thickness and increase the density of the sponge-like chitosan structure to form a densified chitosan structure. The densified chitosan structure is further preconditioned by heating the densified chitosan structure according to prescribed conditions to form a wound dressing. The wound dressing possesses an adhesion strength and resistance to dissolution in high blood flow bleeding situations.

Abstract: A biological wound dressing is made by a method that includes the steps of providing a natural animal tissue that has a substrate, crosslinking and fixing the substrate, minimizing the antigens from the substrate, and incorporating an active layer in the substrate.

Abstract: To provide a patch containing fentanyl for mucous membrane of the oral cavity (oral transmucosal fentanyl), which rapidly increases the serum concentration of the drug, is easy in handling and is superior in safety. The patch can be prepared by laminating on one side of a drug layer which contains fentanyl or its salt as an active ingredient, methyl vinyl ether-maleic anhydride copolymer as an adhesive, and at least one substance selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose and hydroxyethylcellulose as a thickener, a support layer hardly soluble or insoluble in water, and a backing in this order.

Abstract: A wound dressing includes one or more layers containing a first anti-microbial agent and/or at least one zinc-containing agent.

Abstract: The present invention is directed to a compression bandage for the treatment of pain and inflammation, comprising a support substrate and an interpenetrating network of PVA disposed within the support substrate. The bandage provides cooling and delivery of therapeutic compounds. The bandage comprises an open cell foam matrix carrying an incorporated PVA hydrogel and optionally at least one additional therapeutic agent.

Abstract: An apparatus for cleansing and promoting tissue growth in wounds, in which irrigant fluid optionally containing cell nutrients and/or other physiologically active material from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing, a biodegradable scaffold in contact with the wound bed and a means for fluid cleansing and back to the dressing. The apparatus has means for supplying thermal energy to the fluid in the wound. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The dressing and a method of treatment using the apparatus.

Abstract: Disclosed are device for promoting the clotting of blood comprising a clay material and a release agent. In some embodiments, the clay material is disposed within a substrate and the release agent is disposed within a mesh. The release agent can be configured to make direct contact with a bleeding wound when the device is in particle form and the clay material can promote hemostasis.

Abstract: An adhesive skin protector that filters sunlight harmful to skin lesions. The protector includes at least one adhesive layer adapted to adhere to an area of skin having a skin lesion; and at least one filter layer attached to said adhesive layer, the at least one filter layer being adapted to filter sunlight harmful to the skin lesion.

Abstract: This invention involves fabric-supported chitosan modified temperature responsive PNIPAAm/PU hydrogel and the use thereof in preparation of facial mask. The merit of this invention is the hydrogel formed can reversibly swell and deswell near body temperature; the incorporation of PU can suppress the syneresis of PNIPAAm at an elevated temperature; Grafting of PNIPAAm and PU onto the surface of cellulose fabrics can enhance the mechanical strength of hydrogel; Coupling of chitosan to the surface of hydrogel can not only improve the handle and skin affinity, but also render the facial mask antibacterial; The hydrogel is capable of loading a variety of nutrients (or other functional components), which can release at body temperature; the hydrogel facial mask can be reusable with repeated rinsing.

Abstract: A multi-component dressing (100) for treating wounds of the human or animal body, using a reduced pressure, comprising a wound-covering element (4) for mounting the dressing (100) at the surface of the skin and the mucous membrane having at least one connecting site (5) through which material in the wound space (10) can be evacuated. The multi-component dressing has super-absorbing polymers, the absorbed wound secretions remaining bound to polymers in the wound space until the latter are removed from the wound space and the polymers, due to their binding capacity, supporting reciprocal synergies with the sub-atmospheric pressures. Wound exudate, promoted by the reduced pressure, is also stored and controlled by polymerized granulates.

Abstract: A wound treatment device comprising a water-impermeable envelope having at least one aperture. The envelope contains a therapeutic substance. The at least one aperture in the envelope is blocked by a material that breaks down in the presence of one or more active components of wound fluid thereby permitting the therapeutic substance to contact the wound fluid. Preferably, the aperture is blocked by a material that is a substrate for an enzyme present in would fluid, such as a protease.

Abstract: The invention provides a wound dressing comprising a layered material comprising a hydrophilic foam layer formed from a first polyurethane and a hydrogel layer formed from a second polyurethane, wherein the hydrogel layer is laminated to the hydrophilic foam layer.

Abstract: A patient-friendly medical device is provided for removal of excess fluids from body tissue and is particularly useful to treat soft tissue inflammation, damage, edema and/or lymphedema. The comfortable medical device comprises a composite multilayered assembly that provides a gradient pressure compression device to compress body tissue of a patient in a controlled and graduated manner. The composite multilayered assembly can have an inner and/or outer layer to enhance uniform distribution of compression about the affected portion of the patient and can have flexible intermediate layers with elastomeric components such as foamed chips, foamed pieces, and/or chopped foam that can have a different density and/or size and/or shape to form channels (canals) therebetween to enhance flow of excess fluids from the body tissue of the patient. The channels or canals can create zones of gradient pressure to help move excess fluid from the tissue of the affected portion of the body of the patient.

Abstract: Hydrocolloid-containing pressure-sensitive adhesive compositions for medical use are disclosed which contain networks of fibrillated polymeric fibers that have surface areas of at least 4 square meters per gram and which have superior properties of low cold flow and high cohesive strength.

Abstract: A biocompatible wound dressing comprised of a pad for insertion substantially into a wound site and a wound drape for sealing enclosure of the foam pad at the wound site. The pad, comprised of a foam or other like material having relatively few open cells in contact with the areas upon which cell growth is to be encouraged so as to avoid unwanted adhesions, but having sufficiently numerous open cells so that drainage and negative pressure therapy may continue unimpaired, is placed in fluid communication with a vacuum source for promotion of fluid drainage, as known in the art. The pad is further comprised of an ultra-low density fused-fibrous ceramic, or a bioabsorbable branched polymer, or cell growth enhancing matrix or scaffolding.

Abstract: For application of active substances to a wound surface a porous padding (12) is provided upon the wound (10), which is sealingly covered over with a foil (14). A fluid active substance is introduced into the padding (12) via a supply line (22) and is then suctioned out of the padding (12) via a removal line (26). Closure mechanisms (32, 34) control the introduction of the active substance and the suctioning off of the active substance in the manner, that the active substance after being introduced remains for a predetermined dwell time in the padding (12), before it is suctioned off. After the suctioning off the vacuum in the padding (12) is maintained for a certain time period, before renewed introduction of the active substance. The opening of the closure mechanisms (32, 34) are temporally controlled to occur slowly.

Abstract: Provided herein are protective laminate devices comprising a biocompatible non-adherent substance and a fast-setting adhesive and methods of use. Also provided is a dispenser for an adhesive tape. The protective laminate devices and methods may be used for wound closure.

Abstract: A method for stimulating new tissue growth is provided in which a limb is introduced into an interior portion of an outer cover. A porous component is applied to at least a portion of the limb within the outer cover. An opening through which the limb was introduced is sealed, and a negative pressure is applied to the interior portion to stimulate new tissue growth.

Abstract: An apparatus for cleansing wounds with means for stressing the wound bed and optionally tissue surrounding the wound, in which irrigant fluid from a reservoir connected to a conformable wound dressing and wound exudate from the dressing are recirculated by a device for moving fluid through a flow path which passes through the dressing and a means for fluid cleansing and back to the dressing. The cleansing means (which may be a single-phase, e.g. micro-filtration, system or a two-phase, e.g. dialytic system) removes materials deleterious to wound healing, and the cleansed fluid, still containing materials that are beneficial in promoting wound healing, is returned to the wound bed. The means for stressing the wound bed and optionally tissue surrounding the wound promotes wound healing. The dressing and a method of treatment using the apparatus.

Abstract: A wound dressing includes one or more layers containing a first anti-microbial agent and at least one of: a chelating agent, and a second anti-microbial agent.

Abstract: A stretchable bandage comprises a knitted fabric comprising a plurality of yarns (b), (c) of a first inelastic material, e.g. viscose knitted together with yarns (a}, (d), of a second elastically extensible material (e.g. elastane). As shown, the yarns may be knitted from a pair of yarns, one viscose (c) and one elastane (d) fed together and occupying a common yarn path, and separated from the next such pair of yarns by a viscose yarn (b) and an elastane yarn (a) fed separately as single yarns.

Abstract: A wound treatment-dressing is shown which includes a dressing body formed from a medically inert, moisture permeable, urethane open-cell foam which is hydrophilic in nature. The foam body has a foam matrix of interconnected foam cells with cell walls which have incorporated therein a combination of inorganic antimicrobials as active agents, the active agents being incorporated into the foam matrix both topically on a foam cell surface and integrally within the foam cell wall. The antimicrobials are manufactured in a selected particle size range which improves predictability and performance of the wound dressing.

Abstract: A tissue treatment device has a flexible treatment portion that includes one or more parts and holes arranged in an openwork. A treatment area is defined in the openwork. The treatment portion is deployed such that the treatment area is positioned over tissue to be treated. The openwork minimizes contact between the tissue treatment device and the tissue being treated. A flexible cover is secured against the flexible treatment portion to close the holes and form a treatment volume in the openwork. The minimal contact between the tissue treatment device and the tissue being treated promotes a desired clinical objective.

Abstract: A wound dressing comprising: a therapeutic agent selected from the group consisting of antimicrobial substances, pain relieving substances, protease inhibitors, and mixtures thereof; and a barrier layer for initially separating the therapeutic agent from a wound fluid in use, wherein the barrier layer comprises a substrate for an enzyme selected from the group consisting of proteases, kallikrein and tissue-plasminogen activator. Preferably the substrate comprises a substrate for elastase or a collagenase. The barrier layer breaks down in infected or chronic wounds, thereby releasing the therapeutic substance selectively into such wounds.

Abstract: Methods for improved treatment of wounds on a patient. Method includes locally administering a healing composition to the skin wound such that the healing of the skin wound is enhanced. The healing composition includes from about 5 mg to about 40 mg lidocaine hydrochloride per gram of the healing composition, from about 250 units to about 2000 units polymyxin B sulfate per gram of the healing composition, and from about 10 units to about 100 units bacitracin zinc per gram of the healing composition.

Abstract: An apparatus for promoting the clotting of blood and controlling bleeding comprises a receptacle for retaining molecular sieve material in particulate form therein. A pad for controlling bleeding comprises a mesh structure and a rigid or semi-rigid support attached to the mesh structure to facilitate the application of pressure to the pad and the wound. A bandage applicable to a bleeding wound comprises a mesh structure and a flexible substrate attached to the mesh structure, the substrate being a cloth or plastic member that may be adhesively attached to cover a wound. In any embodiment, at least a portion of the receptacle or mesh structure is defined by a mesh having openings therein, and at least a portion of the particulate molecular sieve material is in direct contact with blood.

Abstract: A flexible dressing for direct application to a wound for absorbing exudates. The dressing comprises an alginate fiber sheet having honey fully impregnated through the fiber sheet such that the dressing has moist surfaces, and on application to the wound, the dressing becomes gel-like as exudate is absorbed.

Abstract: The invention relates to a formulation for preparing an antimicrobial lubricious hydrophilic coating, which formulation comprises a hydrophilic polymer; an initiator; particles comprising metallic silver (i.e. Ag°); and a carrier liquid. The invention further relates to an article comprising a hydrophilic coating on a surface wherein the coating comprises a cured hydrophilic polymer and particles comprising metallic silver.

Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.

Abstract: This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial effect.

Abstract: A method of treating a wound may include introducing a wound compress into the wound and compressing it into the wound. The wound compress may include a sealed, fenestrated pouch, and particles inside the pouch, each particle having a smallest linear dimension larger than the largest linear dimension of the pouch fenestrations.

Abstract: An integrated wound dressing system and method including a bandage and a self-contained receptacle that stores treatment material for the care and treatment of wounds. The treatment material is easily accessible and can be removed from the receptacle through an exit. The treatment material can then be used to control bleeding and/or clean the wound before dressing. The bandage may include a layer of plastic that acts as an occlusion barrier to reduce heat loss and maintain moisture levels at the wound site. The occlusion barrier also acts to prevent the passage of air into or out of the wound site. The bandage also includes fasteners that act to prevent unintentional unraveling and to secure the bandage during final packaging. These fasteners help facilitate the wrapping of amputations, stumps, and extremities. The integrated wound dressing system provides an all-in-one system for treating and dressing wounds and reduces the time required to do so.

Abstract: A multi-layer reduced pressure delivery apparatus is provided for applying reduced pressure tissue treatment to a tissue site. The multi-layer apparatus includes a tissue contact layer, a release layer, and a manifold layer. The tissue contact layer includes a scaffold adapted to contact the tissue site, the release layer includes a hydrogel-forming material and a plurality of flow channels, and the manifold layer includes a distribution manifold. The release layer is positioned between the tissue contact layer and the manifold layer to allow easy release of the manifold layer from the tissue contact layer following the administration of reduced pressure tissue treatment.

Abstract: Novel silver-triclosan salts are provided which have antimicrobial properties and may be used as pharmaceutical compositions or to treat articles such as medical devices, packaging materials, and textiles.

Abstract: A monolithic device for transdermal administration of an active pharmaceutical ingredient which is selected from propargylamines and rivastigmine and is liquid at 25° C., has an adhesive matrix layer which includes the active ingredient in an acrylic polymer pressure sensitive adhesive without cross-linker agent containing a metal atom, the adhesive having a shear value of between 1.5 and 15 hours, and further includes a non-volatile coadjuvant selected from squalene and triethylcitrate present in the layer in an amount of 1 to 15 wt %. The combination provides good release of the drug in use, reduces loss of the drug during a drying step in manufacture, reduces chemical interaction of the layer with the drug and achieves low level of skin irritation.

Abstract: The present invention discloses a medical device selected from a group consisting of medical devices, implants wound dressings, comprises at least one insoluble proton sink or source (PSS). The medical device is provided useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises, inter alia, (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment.

Abstract: A disposable bandage for covering a wound area of a skin surface includes a self adhesive first fastener portion and a second fastener portion, a dome having a generally rectilinear shape and constructed from a thin rigid material, the dome being coupled to the first fastener portion along one edge and coupled to the second fastener portion along a second edge. The dome includes pleats that extend across the dome shape from the top edge to the bottom edge of the dome. A gasket is formed of a stretchable material and extends around the underside of the dome. The gasket is held in contact with the skin surface.

Abstract: Fibrous articles having fibers coated with one or more polyelectrolyte layers are disclosed. Methods of making and using the fibrous articles are also disclosed.