Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop iii which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: Heat transfer catheter apparatus and methods of making and using the same are disclosed wherein fluid connection means is provided between the distal portions of two adjacent, thin walled, high strength fluid lumens to define a closed loop fluid circulation system capable of controlled delivery of thermal energy to or withdrawal of thermal energy from remote internal body locations.

Abstract: Implantable tube, for heating by conduction a heat transfer fluid for injection into all or part of a human or animal tissue, is provided with a wall having distal, median and proximal parts and comprising connecting elements for direct or indirect connection of the distal part to a fluid reservoir, and two means for connection to the terminals of an electric power supply, for incoming and outgoing current in the wall. The tube has a resistance less than 0.01? in its median and proximal parts, and a resistance of between 0.2 and 2 ? in its distal part. The median and proximal parts are connected electrically in series to the distal part; the tube having no additional electrical resistance.

Abstract: A catheter for treatment of chronic total occlusions includes an occlusion breach device, a catheter body made of a temperature-dependent softening, shape-memory, thermoplastic polymer having a first flexible state and a second stiff state. The catheter body has a heat transfer conduit and a conduit for slidably receiving the breach device. A heat-transferring device selectively changes a temperature of the heat transfer conduit to, thereby, change stiffness of the catheter body between the two states. To treat a CTO with the catheter, it is warmed above the glass-transition temperature and below the melting-temperature to make the catheter flexible. The catheter has a shape when inserted at the occlusion site and is cooled to, thereby, stiffen. Breaching of the occlusion is assisted with the stiff catheter. The catheter is removed by warming the polymer. Also provided is a method for manufacturing such a selectively stiffening catheter.

Abstract: Medical devices using fluid or cooling fluids having one or more bimaterial valves positioned at each point of flow control to control the flow of a fluid in response to temperature changes. In particular, devices for ablating tissue having multiple ablation elements or cells include one or more bimaterial valves positioned within or near the ablation cells. The bimaterial valves respond to temperature changes by adjusting the flow rate of a fluid through the valve.

Abstract: A fluid warming cassette for use in a fluid warming system includes a first sheet, a second sheet and a flexible spacer having a serpentine opening. At least one of the first and second sheets is a flexible plastic sheet. The spacer is positioned between the first and second sheets and the first and second sheets are joined together over the spacer to form a fluid container having a fluid channel. The fluid container includes a fluid channel with inlet and outlet ports in fluid communication with the fluid channel. The fluid warming cassette is capable of operating under negative pressure without collapse of the fluid channel in the cassette.

Abstract: A system and method for injecting a fluid into a patient is disclosed. In some embodiments, the system comprises a plurality of sensors that measure a characteristic of the fluid, a first temperature regulator that biases the fluid temperature to a desired temperature range, a second temperature regulator that refines the temperature of the fluid, and logic coupled to the first and second temperature regulators and configured to dynamically adjust the first and second temperature regulators based, at least in part, on feedback from the plurality of sensors.

Abstract: A system for dispensing irrigation fluids, including a hand operated dispensing unit connected through a continuous length of multi-tube conduit to a mobile reservoir cart. The dispensing unit is constructed of disposable materials. The conduit system is uninterrupted to provide a sealed delivery of the irrigating fluids to the dispensing unit. Flow control is through a trigger mechanism on the handheld unit, as well as a plurality of individual on/off valves. A variety of nozzles are provided including devices for flushing and/or debriding. The reservoir unit includes disposable containers for the variety of irrigation fluids that are positioned in place and connected to the tubing conduit that extends to the handheld unit. A fluid heating unit may optionally be incorporated. Rotary tube pumps provide a nearly continuous flow of fluid and are capable of continuous operation even with back pressure due to flow stoppage at the handheld unit.

Abstract: A pump system simply and selectably controls the temperature, flow rate flow volume, and flow pressure of a fluid being infused into a patient's body. The pump system a includes a central controller and user inputs that allow for simple selection and efficient operation of the pump system, which includes manually or automatically priming the pump system to remove air, selectably controlling and rapidly adjusting the flow rate over a wide range, selectably and safely controlling the pump system temperature controls, and selectably controlling the flow pressure during delivery. The pump system includes a pump housing with a central controller and a cartridge with infusion tubing removably coupled to the pump housing.

Abstract: An ophthalmic injection system is disclosed. The system has a dispensing member, a plunger, an actuation chamber, a lock mechanism, a lock stop, a port, a source of pressurized gas, and a shaft. The lock mechanism travels in the actuation chamber in an axial direction toward and away from a distal end of the dispensing member. The lock stop is located on the inner surface of the actuation chamber. The lock stop is engageable with the lock mechanism such that when the lock mechanism travels in the axial direction toward the distal end of the dispensing member to a first position located on a distal side of the lock stop, the lock mechanism cannot travel in a reverse direction away from the distal end of the dispensing member to a location on a proximal side of the lock stop.

Abstract: Intravascular closed loop heat exchange catheters are used to manage temperature in burn patients.

Abstract: Devices and systems are describe for treating intraluminal locations such as in a patient's lung. The device has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide. The device also has an outer surface formed of heat resistant material. High temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and distal to the location. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the shaft to prevent proximal flow of the high temperature vapor upon discharge from the device.

Abstract: A method is disclosed for delivering a quantity of a substance into an eye. By applying compressed gas into an actuation chamber, a separating member connected to a lock mechanism and a plunger is displaced. The plunger displaces the quantity of the substance from a dispensing member and into an eye. The plunger is retained in an extended position so that the quantity of the substance is not retracted back into the dispensing member when the dispensing member is removed from the eye.

Abstract: A catheter system and method are provided for delivering a substance, such as medication, to body tissue. The catheter system includes a medication delivery tube and at least one heat transfer fluid passage that at least partially surrounds the medication delivery tube. The catheter system may be used to deliver temperature-sensitive substances, such as, for example thermo-sensitive polymers, to living tissue.

Abstract: An ophthalmic injection device has a dispensing chamber housing, a plunger, an actuator for driving the plunger, a temperature control device, and a temperature release mechanism. The dispensing chamber housing has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering the temperature of the substance in the dispensing chamber. The temperature release mechanism is in a locked position when the substance is outside the proper temperature range and an unlocked position when the substance is in the proper temperature range.

Abstract: A fluid warming device for warming medical fluids, such as intravenously administered blood or saline solutions, is provided. The fluid warming device includes a conduit at least partially formed from a material with positive temperature coefficient properties. A supply of blood or other fluids may pass through the device and be heated to temperatures appropriate for administration to a patient.

Abstract: A method for exchanging heat with a patient's spinal column incident to spinal surgery or to relieve a patient for a hypoxia condition of the spine. A closed loop heat exchange catheter is percutaneously advanced into the retroperitoneal space of the patient or into the vasculature, and then heat exchange fluid is circulated through the catheter to cool the spinal column.

Abstract: An installation for delivering calories to all or part of human or animal cell tissue via a liquid comprises: a heating unit heating the liquid; an injection unit injecting the liquid into the heating unit; a dispenser for dispensing the heated liquid; and a transporter for transporting the liquid from the heating unit to the dispenser. The installation allows the heated liquid to be dispensed from the dispensing means in a pulsed operation.

Abstract: An elastic tube (40) is connected to the base end portion of a catheter main body (1) having a balloon (2) at its top end portion. When the elastic tube (40) is set at a vibrator device (RP), the end portion side of the elastic tube, projecting outside, works as a margin volume part (40A). A roller (53) of the vibrator device (RP) can have a shut-off state where the elastic tube (40) is pressed and completely closed, and a communication state where the elastic tube cannot be pressed. When the roller (53) is rotated in a predetermined direction with the inside of a route from the balloon (2) up to the elastic tube (40) filled up with a liquid for heating, the liquid in the elastic tube (40) is pressed toward the margin volume part (40A) in the shut-off state, while in the communication state, the pressurized heating liquid in the margin volume part (40A) flows backward to the balloon (2) side. Repeating the pressurizing and the backward flow vibrates the heating liquid in the balloon (2).

Abstract: Devices and methods to cool a target tissue region inside the body are described. Fluid cooled below normal body temperature and blood at a normal body temperature are provided to the tissue region in proportions to cool the tissue region. A system for controlling the temperature of the target tissue region is disclosed. The system includes a catheter and a control system that controls the amount of cool fluid and blood provided to the tissue region. A catheter for providing cool fluid to the tissue region is also provided. The catheter includes a temperature sensor that extends to a location distal to the distal end of the catheter to sense the temperature of the tissue region.

Abstract: Cooling apparatus (and method) for reducing the risk of, and/or alleviating, male infertility, particularly in a heated environment, includes: a pouch to enclose the scrotal area of the male user; a thermoelectric cooling device to be worn by the male user at a distance from the pouch; and a fluid pump also to be worn by the male user for pumping a cooling fluid from the cold side of the thermoelectric cooling device to the pouch, and a cooling fluid over the hot side of the thermoelectric cooling device to dissipate the heat generated therein to the atmosphere. The thermoelectric cooling device and pump are incorporated in a waistband to be worn around the waist of the male user.

Abstract: The temperature control means (5c, 5c) of an elastic heating profile (1), which heat and/or cool a medical instrument inserted into a cavity (3) of the heating profile (1), are provided in bores (4a, 4b, 4c, . . . ) having a bore diameter (110, 110?) which is smaller than the outer diameter (120, 120?) of the temperature control means (5c, 5e) to be inserted into the bores (4a, 4b, 4c, . . . ). A positive and/or non-positive connection between the heating profile (1) and the received temperature control means ensures good thermal contact. The production costs for an operable heating profile or temperature control means are also reduced.

Abstract: A fluid warming cassette useful in a system for warming parenteral fluids is provided. The cassette comprises a thermally conductive, flexible fluid container with a fluid channel. Rails are disposed in the fluid container near its periphery, and a stiffener is disposed in the fluid container, between the rails, near an end of the cassette. Together, the rails and stiffener impart structural rigidity to the fluid container. The fluid container, rails and stiffener are joined into an integrated structure useful as a fluid warming cassette. One or more of the rails has a multilateral shape to key the cassette for insertion into a fluid warming unit.

Abstract: A tube for exchanging heat between inside fluid and outside fluid includes a uniform cross-section portion. The outside fluid flows in an outside passage meanderingly extending in an outside fluid flowing direction. The uniform cross-section portion is disposed at least at each end of the tube longitudinal direction, and has an inside passage and a joint. The inside passage is constructed with a first inner face and a second inner face, which are spaced from each other, and the inside fluid flows through the inside passage. The joint is constructed with the first inner face and the second inner face, which are connected to each other to increase a pressure-resistant strength.

Abstract: A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.

Abstract: Various present invention devices enable adherence to requirements for medical items. A medical item of the present invention includes a monitoring or data recording device to monitor and/or record medical solution conditions. The device may further include indicators to indicate compliance of the medical solution with prescribed requirements (e.g., manufacturer, medical standard or regulation, etc.). The medical item may alternatively include a barcode or transponder to uniquely identify the medical item to a thermal treatment system measuring and storing conditions in a central database. The present invention further includes various thermal treatment systems that monitor medical items for prescribed requirements and display the monitored parameters to medical personnel. In addition, the present invention may place time stamp information on medical items to enable determination by medical personnel of compliance with prescribed requirements.

Abstract: A device for heating or cooling medical fluids to be administered to a patient is disclosed. The device comprises a hollow, cylindrical heat/cold exchanging body having external grooves for receiving flexible tubing, the body comprising conductive material for transferring heat or cold from the medical fluid flowing to the patient. A method of using the device is also disclosed.

Abstract: The present invention relates to a portable apparatus for warming biocompatible fluids for use in the treatment of injured patients. The present invention may be used to warm intravenous fluids for trauma resuscitation or to warm air from a ventilator circuit. The portable nature of the present invention makes it highly suitable for field applications, such as a forward surgical hospital near a combat zone.

Abstract: A catheter system for controlling the body temperature of a patient by modifying the temperature of blood flowing within a blood vessel of the patient. The catheter system comprises a catheter body having a heat exchange region in contact with the blood; and a mechanism for moving the heat exchange surface, thereby increasing heat exchange between the heat exchange surface and blood flowing past the heat exchange surface. Various methods of moving the heat exchange surface are disclosed.

Abstract: This invention prevents the danger of falling of body temperature by making the blood temperature similar to the body temperature in the injection of Ringer's solution fluid or blood transfusion, and also alleviates the patient's pain and improves the speed at which Ringer's solution fluid or blood enters the body. The warming device is much cheaper than previously released products, and small and light in weight, and allows blood or solution fluids to flow most effectively by allowing sufficient time for heat transfer as a pack type. The operation is convenient and sanitary in its single usage only. The inventive purpose has the methods of utilizing the temperature sensor in adjusting temperature by utilizing them PTC heating element's resistance specialty against the temperature as well as temperature sensor.

Abstract: This invention is based on combining dual heating means to warm the infused blood or other fluids to a normal body temperature and to compensate for any heat loss from the intravenous line. The infusate is directly heated to a normothermic temperature inside the apparatus as it flows in a plastic pouch having a winding shape passage. A particular object of the present invention is to provide a new and improved intravenous line heat exchanger to further warm the infusate at high flow rates, or to compensate for any heat loss to the environment at low or stagnant flow rates. The present invention provides a closed circuit heating fluid for the intravenous heat exchanger. The heated fluid used to warm the infusate in the intravenous line is maintained in a clean and isolated circuit. Either dray or wet fluids are used to warm the infusate in the intravenous line heat exchanger. The wet warming fluid is supplied in a disposable pouch fitted inside a warming chamber and integrated with the intravenous line.

Abstract: Catheters for treating body fluids, particularly blood, include one or more tubes through which a working fluid is circulated. The fluid characteristics, e.g., temperature or drug content, interact with the body fluid by transfer through the tube walls. For enhancing the efficiency of such transfer, energy is added to the body fluid where it contacts the tube outer surfaces for reducing the thickness of thermal and concentration boundary layers at the tube surfaces. The energy adding is accomplished by causing pulsations in the walls of the tubes, or in the dimensions of a balloon parallel to the tubes, by means of pressure pulsations in the fluids circulated through the tubes and/or the balloon. Systems are disclosed for providing and controlling the circulation of various fluids and drugs through the catheter.

Abstract: An improved surgical console for use with a handheld tissue fragmentation device includes portable base having an upper portion. An adjustable display head is mounted to the upper portion of the base. The display head provides rotational and translational adjustment relative to the base. An aspiration system is coupled to the fragmentation device for aspirating fluid and tissue fragmented by the fragmentation device from a surgical site. An irrigation system is also coupled to the fragmentation device for supplying irrigating fluid to the surgical site for suspending tissue fragmented by the fragmentation device. A power system is coupled to the fragmentation device for energizing a transducer of the fragmentation device for fragmenting tissue.

Abstract: A method for providing a therapeutic effect to a treatment site within a patient's vasculature comprises positioning a catheter at the treatment site. The catheter includes a heating element and a fluid delivery lumen that is coupled to an exit port within a distal region of the catheter. The method further comprises passing the therapeutic compound through the delivery lumen and the exit port at a flow rate. The heated therapeutic compound is provided to the treatment site. The method further comprises exposing at least a portion of the treatment site and at least a portion of the delivered heated therapeutic compound to ultrasonic energy generated by the ultrasound radiating member.

Abstract: A catheter for injecting a thermally sensitive gelation material to remote sites within a patient's body by maintaining the thermally sensitive gelation material in a liquid state until it is delivered to a target area within the body.

Abstract: A catheter having a heat transfer device at or near its distal end, wherein the heat transfer device is layered or coated onto or into the catheter wall is described. The heat transfer device is preferably a flexible film having one or more electrical resistor flow paths thereon or therethrough, or is disposed directly onto the catheter wall by a deposition process. The heat transfer device may alternatively be formed by a length of the catheter wall being formed wholly, substantially of partly from doped material able to act as a heat transfer device upon application of power therethrough. The heat transfer device is preferably powered by one or more metal wires co-extruded within the catheter body.

Abstract: The invention relates to balloon catheters (1) and methods of treatment for exerting internal pressure on surrounding tissue of a mammalian duct or cavity in a section thereof having a substantially circular cylindrical configuration. The elongate rigid distal section and the intermediate section of the catheter contain a central tube (3), whose distal part is provided with at least one outlet (23) for medium within the balloon, and whose intermediate part is surrounded by an axially displaceable tube (4), onto whose distal end the proximal end of the balloon is attached. The balloon has an envelope which is constituted by at least one substantially gas- and liquid-impermeable and elastic internal layer and an external layer of limited radial expansion, said expansion being substantially independent of the axial length of said balloon. The balloon may he encompassed by a radially expandible stent (40), or can be equipped with means for supplementing treatment using pressure with heat treatment.

Abstract: An in-line fluid heater for heating fluid, such as dialysis fluid for use in dialysis therapy is provided. The fluid heater is a dual heater having a primary infrared heater and a secondary plate heater. A controller is operatively connected to the infrared heater and to the plate heater and operates one or both of the infrared heater and the plate heater to maintain a temperature of the fluid.

Abstract: Stabilizing an object in the body of a patient involves the injection of a lower critical solution temperature (LCST) material or other flowable material into the body of the patient so that the material contacts the object. The LCST material or other flowable material then forms a gel in the body such that the object is contained at least partially within the gel and thereby stabilized by the gel such that the object can then be easily fragmented within the body and/or retrieved from the body.

Abstract: A fluid circuit for circulating coolant in a closed loop between an intravascular catheter and a heat exchange system includes a buffer IV bag in fluid flow series with the catheter between the catheter and a pump that pumps the coolant to the heat exchange system. A conventional IV bag is connected by means of a spike and tube to the buffer bag.

Abstract: A device for warming fluids being administered intravenously to a patient. The heating assembly comprising a warming pouch is wrapped and secured around a tube through which fluid is intravenously provided to the patient.

Abstract: A temperature sensing device measures the temperature of a fluid at selected locations along an IV fluid line. The device is secured to a selected portion of the IV line and includes a temperature sensor for measuring fluid flowing within that line. The device is coupled to a temperature display device to display the measured temperature. The temperature sensing device may include: a housing with a lower cover to engage the line and a temperature sensor; a holder movable along the line and including a temperature sensor; a housing with a lower member including a tip to pierce and measure temperature of fluid within the line; a resilient member with a spiral configuration and a tip to pierce and measure temperature of fluid within the line; a ‘T’-type fitting including a temperature sensor; or a ‘Y’-type fitting including a temperature sensor in the form of a needle.

Abstract: A balloon catheter is used in a closed-loop heat exchange system for manipulating the temperature of a patient. The balloon catheter is positioned in the stomach of the patient, and then expanded with a heat exchange fluid delivered through a lumen formed in the shaft of the catheter. The balloon catheter comes into contact with the wall of the stomach, and the stomach substantially conforms around the expanded balloon catheter. The heat exchange fluid is allowed to flow continuously into and out of the balloon catheter. Heat is exchanged between the balloon catheter and the stomach so as to controllably alter the temperature of at least a portion of the patient. Anti-shivering mechanisms and automatic control based on temperature feedback from the patient may be used in connection with the heat exchange system.

Abstract: A central nervous system (CNS) catheter assembly adapted for use as a ventriculostomy catheter and a spinal catheter includes a catheter body defining at least one lumen therethrough having a drug delivery branch and a monitoring/sensing branch. The drug delivery branch and the monitoring/sensing second branch are in fluid communication with the lumen. Openings are disposed in fluid communication with the lumen and being located at proximal ends of the drug delivery branch and the monitoring/sensing branch. Another opening is disposed at a distal end of the main body. The assembly further includes a component such as an intracranial pressure/osmotic pressure monitoring system, a fluid drainage system, an attachable introduction aid, a patient surface attachment aid, a micromanipulator and a comprehensive intracranial pressure evaluation and relief system. The assembly optionally includes a filter assembly containing a proton exchange membrane.

Abstract: A method and apparatus are disclosed for liquefying target tissue within a body and aspirating the same while leaving non-target tissue intact. A biocompatible fluid is heated and contacted with target tissue so that the target tissue is melted while non-target tissue remains intact. As the target tissue is being melted it is also aspirated from the body.

Abstract: A fluid warming cassette with a stiffening frame structure and a key mechanism is provided to support a parenteral fluid container. The fluid container is desirably thin to minimize heat exchange inefficiencies. The frame structure permits the thin fluid container to be inserted into the narrow space between fixed position warming plates of a warming unit. The frame structure has a quadrilateral shape with sides and ends. The fluid container is attached, at its periphery to the sides and ends of the frame structure, within the quadrilateral shape. The key mechanism prevents the cassette from being inserted upside down or backwards in a warming unit. Part of the frame structure may be formed into a handle to assist in both the insertion and removal of the cassette from a warming unit.

Abstract: A catheter introduces electrodes in a vein for a minimally invasive treatment of venous insufficiency by the application of energy to cause selective heating of the vein. The catheter is positioned within the vein to be treated, and the electrodes on the catheter are moved toward one side of the vein. RF energy is applied in a directional manner from the electrodes at the working end of the catheter to cause localized heating and corresponding shrinkage of the adjacent venous tissue, which may include commissures, leaflets and ostia. Fluoroscopy or ultrasound may be used to detect shrinkage of the vein. After treating one section of the vein, the catheter can be repositioned to place the electrodes to treat different sections of the vein until all desired venous valves are repaired and rendered functionally competent.

Abstract: An apparatus for performing hypothermia of the body of a patient, or of a selected organ, while delivering a medicament to a selected blood vessel. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in a selected artery. A chilled fluid is pumped through an inner supply conduit of the catheter to cool a flexible heat transfer element in the distal tip of the catheter. The heat transfer element cools the blood flowing through the artery distal to the tip of the catheter. The medicament, such as a vaso-dilator, is delivered either separately or mixed with the chilled fluid, through a very small exit port in or near the heat transfer element.

Abstract: A method of cooling an organ. A portion of a body fluid bathing an organ is withdrawn while a cool fluid is infused. A separate portion of the body fluid can be cooled during the withdrawing. A volume of up to about 5% of the body fluid can be withdrawn. A catheter is provided with a cooling mechanism to contact and cool the body fluid. The catheter can have an inlet port to withdraw body fluid and an outlet port to allow infusion of a cool fluid. Additionally, an organ cooling pump assembly is provided including a pump and a catheter.

Abstract: A self-contained portable unit for heating physiological fluids is disclosed. A heat exchanger is disposable to ensure sterility, and the hot exchanger is attached to a heating system by inserting it between opposed fluid connection elements. One of the fluid connection elements is movable to permit the heat exchanger to be installed and removed easily by inserting one end of the heat exchanger in one of the fluid connection units and moving the other fluid connection unit into contact with an opposite end of the heat exchanges. The heating fluid is heated by an electric heating element and is circulated by an electric pump.