Abstract: Described is a guide device for intraocular injection comprising a base plate having an inner surface and an outer surface, a handle formed on the outer surface, and a hole formed in the base plate and extending through the inner and outer surfaces. The inner surface is adapted to contact an eye ball.

Abstract: A wire protector to cover an exposed portion of a device inserted into an organism comprises a removable backing layer removably joined to an attachment layer, and a transparent covering layer. The wire protector has a first end and a protector strip, the first end including a site wall and a connector wall, the site wall defining an insertion site therein, the site wall further comprising one or more prongs, the prongs facing the insertion site, the protector strip comprising one or more strip walls, such that when the backing layer is removed from the attachment layer, first end is positioned over the device insertion site, the protector strip is positioned over the exposed portion of the device, the protector device covers the exposed device portion. The wire protector stabilizes and protects needle localization wires used in breast biopsies, and can be used for other implanted devices. Also disclosed is a method for covering such exposed portion of such inserted device.

Abstract: Described is a system and associated materials and methods for delivering a fluid to a subject's skin, e.g., for tattoo removal. In one embodiment, the fluid is provided in a continuous flow by associating the fluid with a pump. In another embodiment, a disposable template is provided that allows for precise and ideal placement of eschar-inducing material fluid for, for example, tattoo removal.

Abstract: A system includes (i) a needle for insertion into a port of an implantable infusion device, and (ii) a receiver apparatus having a port location signal receiver module capable of receiving a signal from the implantable infusion device regarding spatial orientation of the port. The system further includes a processor operably coupled to the receiver apparatus and capable of determining the orientation of the needle relative to the port based on the received signal. The system also includes a display operably coupled to the processor. The processor is configured to cause the display to graphically render trajectory of the needle relative to the port. The port is graphically rendered as a target structure having a reference area. The needle is graphically rendered as an object moveable relative to the target structure. Occupation of the reference area by the object indicates trajectory alignment of the port and the needle.

Abstract: Wearable injection guides and manufacture and use thereof are described, which include: a rigid material formed to substantially conform in shape to a topography of a body region of an individual, the rigid material substantially impenetrable to an injection needle, and the rigid material including one or more injection needle access regions arranged in a treatment pattern.

Abstract: Wearable injection guides and manufacture and use thereof are described, which include: a rigid needle-penetrable material having an inner surface and an outer surface, the inner surface having form-fitting contours substantially conforming to a topography of a body region of an individual and the outer surface including one or more fiducials indication of at least one treatment parameter.

Abstract: Injection devices for delivering pharmaceutical compositions into the eye are described. Some devices include a resistance component for controllably deploying an injection needle through the eye wall. The resistance component may be disposed on the injector device, or on a portion of the injection device housing, or on a drug reservoir. Some devices may be removably attached to a drug reservoir, for example, through a luer connector. Other devices may comprise internal luer seal for securely connecting a drug conduit of the device to the luer cavity of a drug reservoir. Yet other devices may comprise a priming-enabling element to facilitate the drug priming of a shielded needle. Related methods and systems comprising the devices are also described.

Abstract: An assembly for identifying a power injectable vascular access port, including a vascular access port and an identification feature. The port is structured for power injection and includes a housing and a septum together defining a reservoir. A radiographic feature incorporated into the port is perceivable via x-ray following subcutaneous implantation, the radiographic feature identifying the port as suitable for flowing fluid at a fluid flow rate of at least 1 mL/sec therethrough. A structural feature of the port is perceivable via palpation following subcutaneous implantation, the structural feature identifying the port as suitable for accommodating a pressure within the reservoir of at least 35 psi. The identification feature is separated from the port and confirms that the port is both suitable for flowing fluid at a rate of at least 1 mL/sec therethrough and suitable for accommodating a pressure within the reservoir of at least 35 psi.

Abstract: A template for locating a proper place for inserting a needle. The template has two reference indicators that are placed on a person's body and an elongated body, with incremental markings on each side of the elongated body, that moves relative to the two reference indicators. The incremental markings on each side of the elongated body can be scaled differently. One reference indicator is placed over the clavicle and the other is placed over the nipple on the same lateral side. The elongated body is moved until the reference indicators are each lined up with equivalent incremental markings on each half of the elongated body. When the reference indicators are lined up with matching incremental markings, a fixed target, positioned between the two sets of incremental markings, will indicate a proper location for inserting a pneumothorax relief needle.

Abstract: Devices and methods for gastrointestinal bypass are described. A gastrointestinal bypass device includes a gastrointestinal cuff and a gastrointestinal sleeve. The cuff may be configured to be attached in the esophagus, and may be sufficiently flexible to expand and collapse to conform with the inside of the esophagus to allow the esophagus to function substantially normally. The sleeve is configured to be coupled to the cuff, and may be made of a material that is floppy or flaccid but does not substantially expand radially.

Abstract: A support tool for a supply assembly delivers a functional fluid to an implantable medical device. The supply assembly defines a supply axis. The support tool includes a support member defining an opening. The opening has a support axis, and the opening is configured to receive the supply assembly. The support member includes a three dimensionally contoured nesting surface that conforms to a corresponding three dimensionally contoured surface of the supply assembly. The corresponding surface of the supply assembly nests against the nesting surface to support the supply assembly such that the supply axis remains substantially fixed relative to and aligned with the support axis.

Abstract: An injection site marking method and apparatus includes a base member having a continuous side wall defining an open top, an open bottom, and an interior area. The open bottom is configured to attach selectively to a serum vial. A liquid retention member is positioned in the interior area and configured to hold a colorized viscous liquid. A cap having a continuous side wall defining an open bottom and interior area is connected to the base member such that the liquid retention member is unexposed. The cap includes a top wall defining an aperture. In use, a syringe may be inserted through the aperture, through the liquid retention member, and into a serum vial so as to withdraw serum and such that the syringe reservoir nose contacts the viscous liquid. The needle is injected into a user's skin until the syringe reservoir nose contacts the skin with the colorant.

Abstract: In various embodiments, a needle is employed in refilling drug-delivery devices.

Abstract: Assemblies for identifying a power injectable vascular access port are described. One assembly includes a vascular access port, a first identifiable feature, a second identifiable feature, and a third identifiable feature. The first identifiable feature is incorporated into the access port and identifies the access port as suitable for flowing fluid at a fluid flow rate of at least 1 milliliter per second through the access port. The second identifiable feature is incorporated into the access port and identifies the access port as suitable for accommodating a pressure within the cavity of at least 35 psi. The third identifiable feature is separated from the access port and confirms that the implanted access port is both suitable for flowing fluid at a rate of at least 1 milliliter per second through the access port and for accommodating a pressure within the cavity of at least 35 psi.

Abstract: A system for administering pain-free injections includes an electric current source having at least two electrodes attached adjacent an injection site, the electric current source producing a variable numbness pattern and providing a frame of reference for identifying a plurality of sub-areas of the injection site; and a probe applied to the plurality of sub-areas of the injection site for pain-response testing, wherein one or more areas of numbness in the variable numbness pattern are identifiable according to the plurality of sub-areas of the injection site. A fence may be removably applied to the injection site and provide a frame of reference for identifying a plurality of sub-areas of the injection site, and may aid in identifying one or more areas of numbness in the variable numbness pattern. The fence may be removably applied to the injection site via a belt or manual pressure.

Abstract: A needle apparatus for aligning a needle with a port of an implantable infusion device includes a needle anchoring portion configured to axially fix the apparatus relative to a needle to be inserted into the port. The needle apparatus further includes a port locating portion fixable relative to the needle anchoring portion. The port locating portion includes a port location signal receiver module for receiving a signal from an implantable infusion device regarding the location of the port of the infusion device.

Abstract: A biopsy marker delivery device includes a cannula, a grip supported adjacent the proximal end of the cannula, and at least one marker disposed within the internal lumen of the cannula. The cannula includes a distal tip closing the distal end of the cannula and a side marker exit port disposed proximally of the distal end of the cannula. The side marker exit port includes a first portion and a second portion extending proximally from the first portion. The first portion has a larger width than the second portion.

Abstract: This device is a compressible chamber designed to inject a liquid medication through a plurality of needles. It is a self-contained, rapidly deployed device that replaces a classic syringe. It consists of a shallow chamber that is closed on one end and sealed on the other with a sliding elastomeric seal. A rigid ring slides up into the chamber that has multiple small double-ended needles mounted through the periphery of the ring perpendicularly so as to be able to perforate the seal of the chamber with the proximal end and simultaneously penetrate the subcutaneous tissues with the distal end thus allowing medication to flow from the chamber into the tissues when pressure is applied to the top of the chamber. The needles are also imbedded in, or juxtapose to a ring of compressible dye-containing material that serves to conceal the needles and provide demarcation of the area injected.

Abstract: The present invention relates to a compression device for stimulating the efflux of a body fluid from a body part. The device has a compression unit with a pressure-application region made of a deformable material, the region being formed to generate a repulsive force between the body part and the compression unit. The repulsive force passes through a force maximum then decreases to serve as an indication that the body part is guided sufficiently firmly and far enough onto the compression unit.

Abstract: A vascular access device is provided with a needle assembly, a catheter assembly configured to slidably receive the needle assembly, and a light emitting assembly configured to couple to the needle assembly. The light emitting assembly and the needle assembly cooperate to shine a beam of light down the bore of the needle to assist with aligning the needle with a penetration site on target tissue. Systems and methods associated with these devices are also disclosed.

Abstract: A device for successively injecting material at predetermined distances between successive injections to body tissue along a desired path of skin surface includes an injector sub-assembly having a needle configured for injecting the material into body tissue, and a displacement sub-assembly configured to facilitate precise displacement of the needle or of the device along the path between successive injections.

Abstract: Assemblies for identifying a power injectable vascular access port are described. One assembly includes a vascular access port, a first identifiable feature, a second identifiable feature, and a third identifiable feature. The first identifiable feature is incorporated into the access port and identifies the access port as suitable for flowing fluid at a fluid flow rate of at least 1 milliliter per second through the access port. The second identifiable feature is incorporated into the access port and identifies the access port as suitable for accommodating a pressure within the cavity of at least 35 psi. The third identifiable feature is separated from the access port and confirms that the implanted access port is both suitable for flowing fluid at a rate of at least 1 milliliter per second through the access port and for accommodating a pressure within the cavity of at least 35 psi.

Abstract: A support tool for a supply assembly delivers a functional fluid to an implantable medical device. The supply assembly defines a supply axis. The support tool includes a support member defining an opening. The opening has a support axis, and the opening is configured to receive the supply assembly. The support member includes a three dimensionally contoured nesting surface that conforms to a corresponding three dimensionally contoured surface of the supply assembly. The corresponding surface of the supply assembly nests against the nesting surface to support the supply assembly such that the supply axis remains substantially fixed relative to and aligned with the support axis.

Abstract: An injection site marking method and apparatus includes a base member having a continuous side wall defining an open top, an open bottom, and an interior area. The open bottom is configured to attach selectively to a serum vial. A liquid retention member is positioned in the interior area and configured to hold a colorized viscous liquid. A cap having a continuous side wall defining an open bottom and interior area is connected to the base member such that the liquid retention member is unexposed. The cap includes a top wall defining an aperture. In use, a syringe may be inserted through the aperture, through the liquid retention member, and into a serum vial so as to withdraw serum and such that the syringe reservoir nose contacts the viscous liquid. The needle is injected into a user's skin until the syringe reservoir nose contacts the skin with the colorant.

Abstract: The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus.

Abstract: The present invention provides the materials and methods related to marking the injection site on a patient's skin. Specifically, the present invention provides the materials and methods for applying a medical marking tattoo containing at least one injecting targeting site, injecting a medical substance into the area of the injection target site, and marking the injecting targeting site using a tattoo activation element. The present invention also provides the materials and methods for a medical marking apparatus that can be used to perform the methods of the present invention to mark the injection site on a patient's skin.

Abstract: The present disclosure is directed to an injector device for delivering an ophthalmic solution to a cornea of an eye. The device may include a base configured to contact part of the eye, and a needle connected to the base, wherein needle may deliver the ophthalmic solution to the cornea.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: Described is a system and associated materials and methods for delivering a fluid to a subject's skin, e.g., for tattoo removal. In one embodiment, the fluid is provided in a continuous flow by associating the fluid with a pump. In another embodiment, a disposable template is provided that allows for precise and ideal placement of eschar-inducing material fluid for, for example, tattoo removal.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes an enclosure including one or more sensors, a controller, and one or more applicators configured to surround one or more joints of articulating bone of a mammalian subject, wherein the one or more sensors are configured to detect one or more physiological conditions of the one or more joints of the mammalian subject, and the controller, configured to communicate with the one or more sensors, is configured to activate the one or more applicators, and wherein the one or more applicators are configured to inject one or more medicaments to one or more joint tissues of the mammalian subject.

Abstract: A peripherally inserted central venous catheter having a position indicator is used in a method of detecting movement of a catheter tip within a patient's superior vena cava. The PICC comprises a catheter having a proximal end with distance marks at measured intervals, an anchor wing system secured to the catheter's proximal end, at least one extension leg secured to the anchor wing system and the position indicator attached to the extension leg. The position indicator has an area for marking a distance signifying an initial external length of catheter which extends from the point the catheter enters the patient to the point it is attached to the anchor wing and/or marking an initial full length or the internal length of catheter which is fully within the patient. Any movement of the catheter's tip is detected by comparing the current external distance mark with the initial external distance mark.

Abstract: Apparatus are disclosed for intraosseous fluid infusion or aspiration of bone marrow of a subject. Particular apparatus include a bone portal (bone-penetrating member) comprising axially-aligned distal and proximal sections. The proximal section extends in a distal direction from a proximate end of the bone portal and the distal section extends in the distal direction from the proximate section to a distal end of the bone portal. The bone portal also comprises a fluid-transport bore extending between a proximal opening in the proximal section and a distal opening in the distal section. At least a portion of the distal section has a cross-sectional area, perimeter, diameter and/or dimension greater than that of the proximal section.

Abstract: A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more microjet applicators supported by the one or more substrates and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.

Abstract: One embodiment having features of the invention is directed to a guide block for an MRI device which has a block body with a proximal face, a distal face, and four parallel passageways extending between the two faces. The first passageway is centrally disposed, the second passageway is disposed vertical or horizontal to the first, the third passageway is located diagonal to the first and has a longitudinal opening in fluid communication with the first passageway, and the fourth passageway is diagonal to the first and in an opposite side of the body from the third passageway. In an alternative embodiment the guide block has at least one passageway that is not parallel to the longitudinal axis.

Abstract: Apparatuses and methods for performing and aiding venipuncture. The apparatuses of the present invention provide the medical practitioner with an improved tool for performing venipuncture methods. The apparatus preferably includes a handle that is connected to a plurality of tines that run roughly parallel to one another. During use, the tines of the apparatus are pressed against the skin of the patient such that they sit astride the vein to be accessed. The distance between the various tines of the present apparatuses varies so as to be able to accommodate a variety of vein widths. The apparatuses of the present invention may have tines at either one or both ends of the body of the apparatus. The apparatuses of the present invention may be used with a variety of vein accentuating devices, such as those that employ light to accentuate the vein to be punctured.

Abstract: A device for use during an intravitreal injection procedure, the device including: a main body portion with a handle at one end for holding the device; and, a contact portion at the other end for contacting the surface of an eye; wherein the contact portion includes a distance indicator for indicating a pre-determined distance from a reference point on the eye.

Abstract: A delivery device including a roller rotatably mounted on an axle, a reservoir, and at least one hollow needle positioned in the roller are in fluid communication with the reservoir, wherein as the roller rotates about the axle, contents of the reservoir pass through the at least one hollow needle.

Abstract: A system is set forth for detection of catheter location for intravenous access, comprising a catheter having a light source for illuminating a needle tip thereof; and an infrared detector and image projector for simultaneously detecting image vasculature and the location of the needle tip below the surface of the skin and in response projecting an image onto the skin to reveal the location of the needle tip relative to the vasculature.

Abstract: A stabilizing apparatus for stabilizing the position of a needle when penetrating the skin of a patient, the apparatus has a frame structure with a base for placement against the skin in the vicinity of an intended needle entry point. A flexible diaphragm is supported by the frame structure and is spaced apart from the base of the frame structure to be disposed at a position away from the skin. The flexible diaphragm is configured to releasably grip the shaft of the needle at a distance from the needle entry point.

Abstract: The present invention relates to the use of syringes for medicinal liquid injections into mammals, particularly humans, with the syringe bearing a marker ink to mark injection site with marker ink. The disclosed embodiments address re-injecting a medical liquid into the skin at the same location as previous injections. The practice of re-injecting medical liquids into the same location can result in indentions, hard lumps, or thickening of the skin, or lipohyperplasia. It can further cause medications such as insulin, to be inefficiently absorbed. Rotating injection sites within arms, thighs, stomach or buttock usually prevents or reduces this problem. A marker is used on the portion of the syringe that touches the skin of a recipient and causes ink or powder to be transferred to the skin of the recipient to mark an injection site for a desired length of time.

Abstract: A Guide for injecting insulin in the abdomen, thigh or arm according to dimension including a wrap-around band and a series of spaced apertures along its length, with the openings of the apertures being sized to receive an insulin dispensing pin of a filled syringe, and with a reminder indicating at which site an injection was last made so as to reduce the possibility of scar tissue or abscess development for senior citizens, especially, forgetting where the most recent injection was made.

Abstract: Apparatus for administering certain nerve blocks includes a sheath constructed from a flexible ultrasound echogenic material, a more rigid introducer/dilator for introducing the sheath into the patient, and an ultrasound echogenic catheter for inserting through the sheath once the distal end of the sheath is in place adjacent the nerve(s) to be blocked and the introducer/dilator has been withdrawn. The catheter has provisions at its proximal end for connecting to a source of local anesthetic. Methods for use of this apparatus are also described.

Abstract: A guide for administering an injection including a guide body contoured for a human mandible; and at least one needle indexing guide on the guide body for the insertion of a needle there through, the guide use to provide a predictable and repeatable way of administering an injection to block a nerve.

Abstract: A puncture device includes a first base plate; a second base plate; a base plate connection part having flexibility and connecting the first base plate and the second base plate in a horizontal direction; an adhesive means provided to surfaces in a same direction of the first base plate and the second base plate; and a puncture needle moving means provided in the first base plate and movably supporting a puncture needle. The puncture needle is supported away from a surface of the adhesive means a given distance and movable substantially in parallel to the surface of the adhesive means.

Abstract: Embodiments of the present invention comprise a guidance system and method for providing an angular orientation of a medical device. The system and method may utilize a fluid-filled portion with a position indicator that floats in the fluid contained within the fluid-filled portion. The guidance system may be coupled to the medical device so that when the angular orientation of the guidance system is varied, the position indicator moves within the fluid-filled portion. The position of the position indicator is designated by angle gradations on the outer portion of the fluid-filled portion.

Abstract: An intravitreal injection system for administering a pharmacological agent formulation to an intravitreal compartment of an eye, comprising (i) an injection member coupled to, or comprising, an internal formulation chamber that is adapted to receive and contain the pharmacological agent formulation therein, (ii) a needle having a first end that is in communication with a formulation chamber and a second injection end, and (iii) a movable platform for positioning the system on the eye, guiding the needle, and limiting the penetration depth of the needle into the eye.

Abstract: The present disclosure is directed to a device for locating a fistula. The device can include a first tine and a second tine each having a distal end and a proximal end with the first tine spaced a distance from the second tine sufficient for allowing a section of a fistula to fit therebetween. A compression member can be placed adjacent to the first tine and the second tine such that the compression member externally compresses and temporarily occludes a fistula thereby increasing blood pressure in a section of a fistula located between the first tine and the second tine.

Abstract: A capsule medical apparatus includes a living tissue drawing portion in which a space for drawing the living tissue into a body of the capsule medical apparatus is formed; a movable unit that includes an engaging unit, which can be engaged with the living tissue of the subject, and that moves on a surface of the body of the capsule medical apparatus and in the living tissue drawing portion; an injection needle that has an ejection port for a drug and that protrudes such that the ejection port is positioned in the living tissue drawing portion; and an injection needle driver that drives the injection needle such that the injection needle protrudes.

Abstract: Systems and methods for orienting a medical instrument relative to at least a portion of a medical device include a first tilt detector associated with the medical instrument and a second tilt detector associated with the medical device. The first tilt detector may be within an orientation device that is coupled to or separate from the medical instrument. The tilt detectors generate signals that may be used to determine the relative orientation between at least a portion of the medical device and medical instrument. For example, in some embodiments, the signals may be used to determine whether the orientations of the portion of the medical device and the medical instrument substantially match.

Abstract: Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.