Injection Or Aspiration Device Having Plural Body Entering Conduits Patents (Class 604/173)
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Patent number: 12233229Abstract: The present invention relates to a perforated plate microstructure module, and more particularly, to a perforated plate microstructure module which can be used to deliver a drug into the skin.Type: GrantFiled: February 23, 2021Date of Patent: February 25, 2025Assignees: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, JUVIC INC.Inventors: Hyung Il Jung, Hui Suk Yang, Hyeon Jun Kim
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Patent number: 12233156Abstract: The present invention aims to manufacture a microneedle device capable of carrying and administering a larger amount of biologically active substance per one microneedle. One aspect of the present invention is a method of manufacturing a microneedle device comprising coating microneedles with a coating liquid, wherein the coating liquid comprises a biologically active substance and a sulfated polysaccharide. The microneedle device manufactured by such a method comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprises a biologically active substance and a sulfated polysaccharide.Type: GrantFiled: June 20, 2019Date of Patent: February 25, 2025Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Ryota Hori, Shinpei Nishimura
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Patent number: 12220550Abstract: Provided is a device for transdermal delivery of drugs. The device includes a separable substrate and is loaded with dual drugs based on an interpenetrating polymer network hydrogel. Also provided are methods of making and using the transdermal delivery device.Type: GrantFiled: November 12, 2021Date of Patent: February 11, 2025Assignee: BUDDHIST TZU CHI MEDICAL FOUNDATIONInventors: Yu-Shuan Chen, Hsieh-Chih Tsai, Chang-Yi Lee, Haile Fentahun Darge, Shinn-Zong Lin, Tzyy-Wen Chiou, Chia-Yu Chang
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Patent number: 12214150Abstract: The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.Type: GrantFiled: May 15, 2020Date of Patent: February 4, 2025Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Emrullah Korkmaz
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Patent number: 12208224Abstract: Embodiments of the present invention provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue. In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion, or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and/or energy are effective to injure or damage tissue, nerves, and nerve endings in order to relieve disease symptoms.Type: GrantFiled: September 2, 2020Date of Patent: January 28, 2025Assignee: Neurotronic, Inc.Inventors: Lixiao Wang, John J. Chen, Yongxing Zhang
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Patent number: 12186516Abstract: The present disclosure relates to a method for producing microneedle arrays in a mold, including a plurality of receptacles that taper from an upper base surface to a lower tip surface, where a first component is fed into at least two receptacles through a feed opening that is spaced apart from the base surface, where the receptacles are filled with an additional component from above the feed opening, where the fillings of at least said two receptacles, which fillings are formed of at least the first component and the additional component, are connected to one another above the base surfaces, and where after the first component and the additional component have solidified, the microneedle array comprising the fillings that have solidified to form needles is removed from the mold.Type: GrantFiled: December 4, 2019Date of Patent: January 7, 2025Assignee: LTS Lohmann Therapie-Systeme AGInventors: Michael Kulik, Andreas Hennig
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Patent number: 12171969Abstract: The present invention relates to a dissolvable microneedle comprising needles made of a water-soluble material assembled on one side of a base, which is a sheet material having liquid-permeable cavities, wherein the needles being assembled to the base such that bottom portion of the needles is directly connected to the base, the connection of the bottom portion of the needle s to the base forming through a structure in which the bottom portion of the needles penetrates into the base (102), occupying some or all cavities of the base. The dissolvable microneedle with the structure according to the present invention is convenient to use as the penetrating structure that connects the needle s to the base can be dissolved quickly and efficiently; therefore, the base can be removed from the top skin without the needles embedded within the skin being pulled out.Type: GrantFiled: August 20, 2019Date of Patent: December 24, 2024Assignee: Mineed Technology Company LimitedInventors: Supason Wanichwecharungruang, Teeranut Rutwaree, Titiporn Sansureerungsikul, Pravit Asawanonda, Wijit Banlunara
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Patent number: 12150671Abstract: Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.Type: GrantFiled: December 20, 2019Date of Patent: November 26, 2024Assignee: Cytrellis Biosystems, Inc.Inventors: Alec Ginggen, Douglas Levinson, David Stone
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Patent number: 12144887Abstract: A method may include providing a syringe device having (a) a single needle, (b) a first syringe comprising saline with microbubbles, (c) a second syringe comprising a therapeutic compound, and (d) a connector coupling the single needle to the first syringe and to the second syringe. The method may further include guiding the single needle to an injection site of a patient; injecting, with the first syringe, a quantity of saline with microbubbles; confirming a desired position of the single needle, with ultrasound imaging, by identifying the microbubbles in the quantity of saline relative to a tip of the single needle and further relative to one or more anatomical landmarks visible with the ultrasound imaging; and injecting, with the second syringe, the therapeutic compound at the injection site.Type: GrantFiled: January 4, 2022Date of Patent: November 19, 2024Assignee: Agitated Solutions Inc.Inventors: Morgan Evans, Kenneth Trauner
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Patent number: 12138415Abstract: A method for delivering a bioactive agent to the cardiovascular system is described. The method delivers the agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. For instance, little or none of the bioactive agent will be sequestered in lymph tissue and prevented from circulation in the cardiovascular system. The method includes utilization of a transdermal delivery device including microneedles with structures fabricated on a surface of the microneedles to form a nanotopography. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes.Type: GrantFiled: August 13, 2020Date of Patent: November 12, 2024Assignee: VIVASOR, INC.Inventor: Russell F. Ross
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Patent number: 12138405Abstract: Disclosed herein are rapidly insertable central catheters (“RICCs”), RICC assemblies, and methods thereof. For example, a RICC can include a catheter tube, a suture wing disposed over a medial portion of the catheter tube, a hub coupled to a proximal portion of the catheter tube, and a number of extension legs extending from the hub. The catheter tube can include a first section in a distal portion of the catheter tube and a second section proximal of the first section. The suture wing can include a projection opposite a patient-facing side of the suture wing and a needle through hole through the projection. The needle through hole can be configured to accept a needle therethrough for insertion of the needle into a primary lumen of the catheter tube, which passes through a catheter-tube through hole through the suture wing. A method of the RICC can include using the RICC.Type: GrantFiled: December 17, 2021Date of Patent: November 12, 2024Assignee: Bard Access Systems, Inc.Inventors: Bryan Haymond, Glade H. Howell
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Patent number: 12090260Abstract: A drainage or infusion catheter and methods of use are disclosed. In one embodiment, the catheter includes a tube body having a proximal end and a distal end, and a plurality of ports arranged along the tube body from the distal end to the proximal end. The distal end of the tube body is configured to deform around itself into a substantially spiral shape so as to cover at least one of the plurality of ports located near the proximal end of the tube body. In another embodiment, a flap is configured to erupt from apertures arranged in the tube and extend outwardly around the tube body so as to cover at least one of the plurality of ports located near the proximal end of the tube body.Type: GrantFiled: April 4, 2022Date of Patent: September 17, 2024Assignee: Duke UniversityInventor: Muath Bishawi
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Patent number: 12078811Abstract: A head mounted device includes a base gasket and a custom gasket rim that is selectively connectable to and disconnectable from the base gasket. The custom gasket rim is configured to intervene between the base gasket and a face of a user.Type: GrantFiled: February 14, 2023Date of Patent: September 3, 2024Assignee: Microsoft Technology Licensing, LLCInventors: Jouya Jadidian, Gabriele D'Amone
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Patent number: 12036378Abstract: A transdermal drug delivery patch according to an exemplary embodiment of the present invention includes: a flexible base layer; and a plurality of microneedle disposed at one surface of the base layer. Each of the plurality of microneedles includes a biodegradable polymer and a drug and has an empty space inside. Each of the plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a part between two protrusions adjacent along the circumferential direction among the plurality of protrusions is concave.Type: GrantFiled: May 18, 2018Date of Patent: July 16, 2024Assignees: POSTECH ACADEMY-INDUSTRY FOUNDATION, SHILLA INDUSTRIAL CO., LTD.Inventors: Geunbae Lim, Jungho Lee, Byoungsun Choi, Hyeonsu Woo
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Patent number: 11986613Abstract: The present invention relates generally to devices comprising one or more microstructures that are used to relieve, treat or prevent pain. The devices are designed such that they are inserted into the superficial layers of the skin to achieve pain relief. The devices are designed such that the microstructures are able to grasp and secure to the skin. The devices may consist of microstructures in arrays that are attached to a backing to enable the devices to adhere to the skin. Also provided are wound closure systems that comprise one or more microstructure devices along with other components, such as protective covers and therapeutics. A variety of packaging specifications are disclosed, as is a dispenser apparatus configured to enable simple one-handed application of the devices. Methods described herein provide for treatment of pain.Type: GrantFiled: February 19, 2021Date of Patent: May 21, 2024Assignee: KitoTech Medical, Inc.Inventors: Robert Arman Audell, Ronald J. Berenson, Cheuk Yin Paul Leung
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Patent number: 11980408Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.Type: GrantFiled: September 5, 2019Date of Patent: May 14, 2024Assignee: Ablative Solutions, Inc.Inventors: David R. Fischell, Tim A. Fischell, Robert Ryan Ragland, Darrin James Kent, Andy Edward Denison, Eric Thomas Johnson, Jeff Alan Burke, Christopher Scott Hayden
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Patent number: 11964113Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.Type: GrantFiled: April 16, 2021Date of Patent: April 23, 2024Assignee: Ablative Solutions, Inc.Inventors: David R. Fischell, Tim A. Fischell
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Patent number: 11918782Abstract: Method and system for providing an integrated analyte monitoring system and on-body patch pump with multiple cannulas and a sensor combination is provided.Type: GrantFiled: January 21, 2019Date of Patent: March 5, 2024Assignee: Abbott Diabetes Care Inc.Inventor: R. Curtis Jennewine
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Patent number: 11895988Abstract: Systems and methods of using an animal wellness notification system to determine the wellness of an animal, the systems and methods comprising: attaching an animal wellness notification system component to an animal, monitoring the temperature of the animal to determine if the animal's temperature remains outside a selected temperature range for a selected time duration, and providing notice if the animal's temperature remained outside the selected temperature range for the selected time duration.Type: GrantFiled: October 9, 2020Date of Patent: February 13, 2024Assignee: FEVERTAGS LLCInventors: John M. Greer, Richard Arelin Crider, Jr., Alvin C. Fults
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Patent number: 11883622Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.Type: GrantFiled: February 18, 2021Date of Patent: January 30, 2024Assignee: SORRENTO THERAPEUTICS, INC.Inventors: Russell F. Ross, Luke Hagan, Alexander Malkin, Derek Hatchett, Jacob Marks, Thomas Lutzow
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Patent number: 11849968Abstract: An invention for connecting an extracorporeal circulation apparatus 35 to the patients' circulatory system 26B for providing extracorporeal blood circulation through a plurality of transfixions 44 in a tissue 25 space apart by a distance, comprising: a holder 10; and the plurality of ducts 14 connected to said holder 10; wherein said holder 10 is adapted to connect to the extracorporeal circulation apparatus 35; wherein at least one of said plurality of ducts 14 is adapted to connect to the patients' circulatory system 26B; wherein said holder 10 and said plurality of ducts 14 includes blood passageways 3. The invention including an internal connection 33 including a proximal portion 33A and a distal portion 33B; wherein said distal portion 33B is adapted to connect to the patients' circulatory system 26B; wherein said proximal portion 33A is connectable to said ducts 14. The methods are provided.Type: GrantFiled: June 27, 2019Date of Patent: December 26, 2023Assignee: Luiz Lanat Pedreira de Cerqueira FilhoInventor: Luiz Lanat Pedreira De Cerqueira Filho
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Patent number: 11819655Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.Type: GrantFiled: December 8, 2021Date of Patent: November 21, 2023Assignee: SOFTHALE NVInventors: Frank Bartels, Jürgen Rawert
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Patent number: 11813218Abstract: Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.Type: GrantFiled: April 9, 2021Date of Patent: November 14, 2023Assignee: The General Hospital CorporationInventors: Richard R. Anderson, Mathew Avram, Fernanda H. Sakamoto, Wikunda Limpiangkanan, William A. Farinelli
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Patent number: 11812933Abstract: An improved endoscopic tool easily and efficiently obtains samples of multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope.Type: GrantFiled: April 19, 2021Date of Patent: November 14, 2023Assignee: Interscope, Inc.Inventor: Cosme Furlong
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Patent number: 11808713Abstract: An ion-jet electron-entangled pathogens analyzer imprinted on a test strip resembles the functionality of a scanning tunneling microscope as a hand-held device, to quickly detect pathogens in water and food products on their bioelectrical signature. The use of such a device does not require special training or preparation. The test strip consists of an integrated circuit which gets energized and communicates over a weak alternating electric field provided by a matchbox-sized base station, which also contains a trained machine learning module of bioelectrical pathogen signatures. The base station connects wirelessly to smart devices or networks for further processing or recording the measurement results in a blockchain. The base station can be worn as a smartwatch or attached to processing machines, transportation vehicles, warehouses, shelves and grocery stores.Type: GrantFiled: July 30, 2021Date of Patent: November 7, 2023Assignee: EPIC SEMICONDUCTORS INCInventors: Wolfgang Richter, Faranak Zadeh
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Patent number: 11793981Abstract: Described is a microneedle device, preferably a controlled release device, for delivery of liothyronine (LT3 or salt thereof) to a patient with hypothyroidism and/or who is not pregnant. The microneedle device contains LT3 or salt thereof in an effective amount to maintain normal, stable levels, in the serum, of free and/or total T3. The microneedle device includes at least two components: multi-dimensional array of microneedle(s) and a substrate to which the base of the microneedle(s) are secured or integrated. The microneedles contain LT3 or salt thereof as well as a biodegradable and/or biodissolvable polymer, such as polyvinyl pyrrolidone for controlled release of LT3 or salt thereof. Also described are methods of making and using the microneedle device.Type: GrantFiled: May 21, 2021Date of Patent: October 24, 2023Assignee: EQUILIBRATE THERAPEUTICS, LLCInventor: Elizabeth A. McAninch
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Patent number: 11793982Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.Type: GrantFiled: June 10, 2021Date of Patent: October 24, 2023Assignees: Purdue Research Foundation, Industry-University Cooperation Foundation Hanyang UniversityInventors: Chi Hwan Lee, Yoon Yeo, Dong Rip Kim
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Patent number: 11772305Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor. The plate precursor comprises a substrate having a larger area than the pedestal in a plan view on a side opposite to a surface of the pedestal on which the protruding pattern is disposed. An edge portion where a side surface of the pedestal and the substrate are in contact with each other has a through-hole penetrating the substrate along the side surface of the pedestal.Type: GrantFiled: October 26, 2022Date of Patent: October 3, 2023Assignee: FUJIFILM CorporationInventors: Aya Mochizuki, Satoshi Chai, Toshihiro Usa, Kozue Ikeda
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Patent number: 11759248Abstract: Disclosed is a medical handpiece having a high frequency heating function. The medical handpiece includes: a needle unit including a needle holder installed outside a distal portion of a handpiece body portion and needles configured to protrude forward from the needle holder; a high-frequency generator configured to apply a high-frequency current to the needle to generate heat when the distal end of the needle is inserted into the epidermal layer; a drug delivery unit installed to deliver a drug to the needle; and a skin expansion member including a guide main body installed to protrude outward of the handpiece body portion and a pair of rotational expansion plates configured to expand a skin in both directions while rotating about a hinge shaft on both sides of a distal portion of the guide main body.Type: GrantFiled: February 5, 2021Date of Patent: September 19, 2023Assignee: AGNES MEDICAL CO., LTD.Inventor: Gunyoung Ahn
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Patent number: 11690989Abstract: Provided is an inexpensive microneedle array with little dimensional error that can control, with high precision, the amount of a predetermined component to be introduced to the inner part of the skin, and a production method for this microneedle array. A foundation that is insoluble or sparingly soluble in inner part of the skin is overlaid on a mold. A plurality of frustum-shaped protrusions, which are insoluble or sparingly soluble in the raw material liquid, provided on a first main surface of the foundation are fit into a plurality of cone-shaped recesses. The raw material liquid in the plurality of cone-shaped recesses dries and, as a result, a plurality of microneedles, which are dissolvable in the inner part of the skin, are fixed to tip surfaces of the plurality of frustum-shaped protrusions.Type: GrantFiled: November 27, 2018Date of Patent: July 4, 2023Assignee: Nissha Co., Ltd.Inventors: Hiroyuki Nagai, Kensaku Akita, Masateru Chiyama
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Patent number: 11672964Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.Type: GrantFiled: July 29, 2020Date of Patent: June 13, 2023Assignee: University of Pittsburgh—Of the Commonwealth System of Higher EducationInventors: Louis D. Falo, Jr., Geza Erdos
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Patent number: 11648382Abstract: A microneedle structure, a manufacturing method therefor, and a manufacturing apparatus therefor are presented. The microneedle structure manufacturing method according to one embodiment of the present invention comprises the steps of: a) injecting, into a lower mold comprising a microneedle intaglio, a polymer solution containing a biocompatible polymer; and b) coupling a shape control mold, which comprises a protrusion, to the lower mold such that one end of the protrusion of the shape control mold is impregnated with the biocompatible polymer solution injected into the microneedle intaglio.Type: GrantFiled: July 6, 2018Date of Patent: May 16, 2023Assignee: KOREA INSTITUTE OF MACHINERY & MATERIALSInventors: Sunghwan Chang, Jung Yup Kim, Jaegu Kim, Yeong-Eun Yoo
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Patent number: 11596778Abstract: The present disclosure relates to an insertion type drug injection device capable of being inserted into a body for injecting a drug into a skin, including: a main body having an open insert part and formed in a tubular shape having a hollow space therein, a needle assembly formed in the insert part, provided with a plurality of needles, and including a pneumatic port and a drug injection port, and a drug injection pipe inserted into the main body and connected to a drug injection port of the needle assembly, and an air flowing pipe connected to the pneumatic port.Type: GrantFiled: April 23, 2020Date of Patent: March 7, 2023Assignee: HUONS MEDICAL CO., LTD.Inventor: Sung Tae Yoon
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Patent number: 11597122Abstract: Provided are a manufacturing method of a plate precursor having a plurality of needle-like protrusions and a manufacturing method of a microneedle array, which make it possible to manufacture a plate precursor within a short period of time. A manufacturing method of a plate precursor having a needle-like protrusion includes: a preparation step of preparing a cutting tool including at least one blade conforming to an external shape of the needle-like protrusion, and a base material; and a cutting step of cutting the base material by rotating the cutting tool about a tool axis of the cutting tool and revolving the cutting tool around an axis of the needle-like protrusion to be formed on the base material to form the needle-like protrusion having a shape conforming to a shape of the cutting tool.Type: GrantFiled: October 3, 2019Date of Patent: March 7, 2023Assignee: FUJIFILM CorporationInventors: Ricardo Itiro Ori, Hiroki Yanagawa, Kozue Ikeda
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Patent number: 11571517Abstract: An injector includes an injector housing, an activation button assembly translatable from an unactuated position to an actuated position and a cartridge door movably mounted to the injector housing between an open position and a closed position. A deflectable interference member has a resting position configured to limit an insertion depth of a cartridge into an interior channel of the cartridge door to a sealed position, wherein the cartridge piercing needle does not fully penetrate a pierceable septum of the cartridge. Movement of the activation button assembly from the unactuated position to the actuated position thereof, in the closed position of the cartridge door, deflects the interference element out of the resting position thereof, thereby enabling further advancement of the cartridge into the interior channel of the cartridge door to an unsealed position, wherein the cartridge piercing needle fully penetrates the pierceable septum.Type: GrantFiled: August 2, 2018Date of Patent: February 7, 2023Assignee: West Pharma. Services IL, Ltd.Inventors: Yossi Bar-El, Gil Yigal, Reuven Y. Filman
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Patent number: 11571859Abstract: A method of forming a chemical delivery device with an active chemical includes generating halftoned image data using a stochastic halftone screen and with reference to a concentration parameter for the active chemical. The method also includes ejecting a chemical carrier including the active chemical into a portion of a plurality of cavities formed in the chemical delivery device based on the halftoned image data to produce the chemical delivery device with a concentration of the active chemical corresponding to the concentration parameter.Type: GrantFiled: October 17, 2018Date of Patent: February 7, 2023Assignee: Xerox CorporationInventor: Patricia J. Donaldson
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Patent number: 11534943Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.Type: GrantFiled: March 3, 2020Date of Patent: December 27, 2022Assignee: FUJIFILM CorporationInventors: Aya Mochizuki, Satoshi Chai, Toshihiro Usa, Kozue Ikeda
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Patent number: 11439323Abstract: A smart patch and a method for fabricating the same are provided. The smart patch includes: a substrate, a detecting component arranged on the substrate, and a reminding component connected with the detecting component, wherein the detecting component is configured to detect a stretch degree of the substrate; and the reminding component is configured to transmit a reminding signal when the stretch degree of the substrate, detected by the detecting component, meets a preset condition.Type: GrantFiled: January 4, 2019Date of Patent: September 13, 2022Assignee: Beijing BOE Technology Development Co., Ltd.Inventor: Kairan Liu
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Patent number: 11419816Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.Type: GrantFiled: February 10, 2020Date of Patent: August 23, 2022Assignee: Corium, Inc.Inventors: Parminder Singh, Danir Bayramov, Guohua Chen, Robert Wade Worsham
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Patent number: 11395878Abstract: Provided herein are an injection device and a method of injecting a patient. The injection device includes a base portion including a body section and a control section, at least one bracket secured to the body section, an articulation element secured to the control section, and a pusher plate coupled to the articulation element, wherein the articulation element moves the pusher plate with respect to the base portion. The method includes positioning at least two syringes in the injection device, placing an injection end of the injection device in contact with an injection site on the patient, and activating the articulation element, wherein activating the articulation element moves the pusher plate towards the at least two syringes, depressing a plunger and dispensing a fluid from the at least two syringes.Type: GrantFiled: March 15, 2019Date of Patent: July 26, 2022Inventor: Daphne Lodge
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Patent number: 11382841Abstract: The present invention relates to a method of manufacturing a microstructure, including: (a) forming a solid on a substrate; (b) fluidizing the solid by adding a solvent thereto; and (c) shaping the fluidized solid, and a microstructure manufactured using the method.Type: GrantFiled: July 13, 2016Date of Patent: July 12, 2022Assignee: JUVIC INC.Inventors: Hyung Il Jung, Hui Suk Yang
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Patent number: 11344332Abstract: An apparatus for removing blackheads and providing skin care treatments comprising a funnel body that comprises a compartment, a first opening and a second opening that are bended about 45 degrees from an axial axis. The first opening further comprises a vacuum tip that is detachable and the second opening further comprises a massage metal plate. The apparatus further comprises a vacuum pump, a CPU, and a PCB. The vacuum tip further comprises a vacuum filter. The funnel body further comprises a smart switch disposed on the outside wall thereof. The apparatus further comprises a lithium battery. The funnel body further comprises vent pores. The apparatus further comprises a status light made of LED.Type: GrantFiled: March 7, 2019Date of Patent: May 31, 2022Inventor: Raymond Hsu
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Patent number: 11344710Abstract: The purpose of the present invention is to provide a microneedle array and a microneedle manufacturing method, which improves medical solution delivery efficiency and facilitates manufacturing. The microneedle array is provided with a first divisional element, a second divisional element to be bonded to the first divisional element, a longitudinal passage formed between the first divisional element and the second divisional element bonded to each other; and a horizontal hole, having an orifice on a lateral side and formed in a direction parallel to a bonding surface of the first divisional element with the second divisional element, and communicating to the longitudinal passage.Type: GrantFiled: March 29, 2018Date of Patent: May 31, 2022Assignee: ASTI CORPORATIONInventors: Noriyuki Ogai, Masahiro Takigawa
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Patent number: 11285257Abstract: An attachable needle assembly (2) is disclosed for use on a medication delivery pen (4). The needle assembly (2) includes a housing (8) enclosing a hub (12) that is configured to engage the medication delivery pen (4), a plurality of needles (18) configured to pierce a reservoir septum (6) of the medication delivery pen (4), a selection ring insert (30) that rotates and identifies which needle (24) of the plurality of needles (18) is to be selected, and a selection ring (36) that applies a force to expose the selected needle (24). When the housing (8) is in a first position, the plurality of needles (18) is not exposed, and when the housing (8) is in a second position, one of the plurality of needles (24) is exposed for medicament delivery.Type: GrantFiled: March 31, 2017Date of Patent: March 29, 2022Assignee: Becton, Dickinson and CompanyInventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
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Patent number: 11224734Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body which has an interior for receiving a liquid, wherein the valve body has a liquid inlet and an opposite liquid outlet which both open into the interior, wherein the interior accommodates a large number of micro channels which extend in a connection direction between the liquid inlet and the liquid outlet. A corresponding device for administering a liquid medicament is also described.Type: GrantFiled: September 14, 2017Date of Patent: January 18, 2022Assignee: SOFTHALE NVInventors: Frank Bartels, Jürgen Rawert
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Patent number: 11185672Abstract: A needling device may be used for needling of a subject's skin, and a drug applicator device may be used for applying a drug to a subject's skin. For example, a needling device may be applied to a subject's skin for hair growth applications, or may be used for wrinkle, scar, or tattoo removal. A drug applicator device may be used for multiple drug application purposes such as applying a hair growth compound to the skin of a subject.Type: GrantFiled: September 27, 2016Date of Patent: November 30, 2021Inventors: David C. Tharp, Scott Kellogg, Daniel DeRuntz, Jason Robinson, Greg Wolos, Alex Staudt, David Chastain, Daniel P. Smith, Justin David Morse, Anthony Vincent Dibella, Joseph Gordon, Nathan Rollins
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Patent number: 11179554Abstract: A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.Type: GrantFiled: April 17, 2017Date of Patent: November 23, 2021Assignee: SORRENTO THERAPEUTICS, INC.Inventors: Andrew T. Baker, Russell F. Ross, Elizabeth Deibler Gadsby, Luke Hagan
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Patent number: 11167119Abstract: The purpose of the present application is to provide a microneedle patch applicator and a microneedle patch applicator housing, whereby perpendicular penetration properties of the needle into skin are enhanced. A microneedle patch applicator housing has a flat peripheral base part configured from a single sheet or film, and a protruding part which is surrounded by the peripheral base part and bulges perpendicularly upward toward a top surface from a bottom surface with respect to the peripheral base part. A bottom-surface portion of the protruding part constitutes part of a microneedle patch support surface. The protruding part is provided with a plurality of recessed fold parts, and the recessed fold parts have recess bottoms oriented in the direction away from a center part of the protruding part.Type: GrantFiled: December 20, 2016Date of Patent: November 9, 2021Assignee: MEDRX CO., LTD.Inventors: Katsunori Kobayashi, Hidetoshi Hamamoto
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Patent number: 11141576Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.Type: GrantFiled: December 15, 2017Date of Patent: October 12, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takuya Tajima, Naoki Yamamoto, Seiji Tokumoto
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Patent number: 11129974Abstract: The present invention provides a fine hollow protruding tool (1) having a basal member (2) and a fine hollow protrusions (3) project from the basal member (2). The fine hollow protrusions (3) each has an opening portion (3h) on a tip side thereof and an interior in which an interior space linked to the opening portion (3h) is formed. In any vertical cross-section passing through an apex of the fine hollow protrusion (3), a wall thickness (T1) in an apex-side region (TB) on the apex side is thinner than a wall thickness (T2) in a lower-side region (BP) that is closer to the basal member (2) than the apex-side region (TB) is, and a gap (M1c) between inner walls (31) in the apex-side region (TB) is smaller than a gap (M2c) between the inner walls (31) in the lower-side region (BP). A base portion (34) of the fine hollow protrusion (3) projecting from the basal member (2) has a curvature.Type: GrantFiled: March 30, 2017Date of Patent: September 28, 2021Assignee: KAO CORPORATIONInventors: Satoshi Ueno, Takatoshi Niitsu, Hideo Kobayashi