Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall.

Abstract: Method and system for providing an integrated analyte monitoring system and on-body patch pump with multiple cannulas and a sensor combination is provided.

Abstract: Systems and methods of using an animal wellness notification system to determine the wellness of an animal, the systems and methods comprising: attaching an animal wellness notification system component to an animal, monitoring the temperature of the animal to determine if the animal's temperature remains outside a selected temperature range for a selected time duration, and providing notice if the animal's temperature remained outside the selected temperature range for the selected time duration.

Abstract: A transdermal drug delivery device is disclosed that may comprise a housing including an upper housing portion and a lower housing portion. The lower housing portion may define a bottom surface including skin attachment means for releasably attaching the lower housing portion to skin of a user. The upper housing portion may at least partially surround a central region of the device. The device may also include a microneedle assembly and a reservoir disposed within the central region. The reservoir may be in fluid communication with the microneedle assembly. Additionally, the device may include a pushing element disposed above the microneedle assembly within the central region. The pushing element may be configured to provide a continuous bilateral force having a downward component transmitted through the microneedle assembly and an upward component transmitted through the skin attachment means.

Abstract: An invention for connecting an extracorporeal circulation apparatus 35 to the patients' circulatory system 26B for providing extracorporeal blood circulation through a plurality of transfixions 44 in a tissue 25 space apart by a distance, comprising: a holder 10; and the plurality of ducts 14 connected to said holder 10; wherein said holder 10 is adapted to connect to the extracorporeal circulation apparatus 35; wherein at least one of said plurality of ducts 14 is adapted to connect to the patients' circulatory system 26B; wherein said holder 10 and said plurality of ducts 14 includes blood passageways 3. The invention including an internal connection 33 including a proximal portion 33A and a distal portion 33B; wherein said distal portion 33B is adapted to connect to the patients' circulatory system 26B; wherein said proximal portion 33A is connectable to said ducts 14. The methods are provided.

Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body (1) which has an interior (2) for receiving a liquid (20), wherein the valve body (1) has a liquid inlet (3) and an opposite liquid outlet (4) which both open into the interior (2), wherein the interior (2) accommodates a large number of micro channels (5) which extend in connection direction (x) between the liquid inlet (3) and the liquid outlet (4). A corresponding device for administering a liquid medicament is also described.

Abstract: An improved endoscopic tool easily and efficiently obtains samples of multiple polyps from a patient by debriding one or more polyps and retrieving the debrided polyps without having to alternate between using a separate cutting tool and a separate sample retrieving tool and may be used with an endoscope.

Abstract: Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to the treated region of skin as the damage heals to facilitate hole closure, and provide enhanced and/or directional shrinkage of the treated skin area.

Abstract: An ion-jet electron-entangled pathogens analyzer imprinted on a test strip resembles the functionality of a scanning tunneling microscope as a hand-held device, to quickly detect pathogens in water and food products on their bioelectrical signature. The use of such a device does not require special training or preparation. The test strip consists of an integrated circuit which gets energized and communicates over a weak alternating electric field provided by a matchbox-sized base station, which also contains a trained machine learning module of bioelectrical pathogen signatures. The base station connects wirelessly to smart devices or networks for further processing or recording the measurement results in a blockchain. The base station can be worn as a smartwatch or attached to processing machines, transportation vehicles, warehouses, shelves and grocery stores.

Abstract: Described is a microneedle device, preferably a controlled release device, for delivery of liothyronine (LT3 or salt thereof) to a patient with hypothyroidism and/or who is not pregnant. The microneedle device contains LT3 or salt thereof in an effective amount to maintain normal, stable levels, in the serum, of free and/or total T3. The microneedle device includes at least two components: multi-dimensional array of microneedle(s) and a substrate to which the base of the microneedle(s) are secured or integrated. The microneedles contain LT3 or salt thereof as well as a biodegradable and/or biodissolvable polymer, such as polyvinyl pyrrolidone for controlled release of LT3 or salt thereof. Also described are methods of making and using the microneedle device.

Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.

Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor. The plate precursor comprises a substrate having a larger area than the pedestal in a plan view on a side opposite to a surface of the pedestal on which the protruding pattern is disposed. An edge portion where a side surface of the pedestal and the substrate are in contact with each other has a through-hole penetrating the substrate along the side surface of the pedestal.

Abstract: Disclosed is a medical handpiece having a high frequency heating function. The medical handpiece includes: a needle unit including a needle holder installed outside a distal portion of a handpiece body portion and needles configured to protrude forward from the needle holder; a high-frequency generator configured to apply a high-frequency current to the needle to generate heat when the distal end of the needle is inserted into the epidermal layer; a drug delivery unit installed to deliver a drug to the needle; and a skin expansion member including a guide main body installed to protrude outward of the handpiece body portion and a pair of rotational expansion plates configured to expand a skin in both directions while rotating about a hinge shaft on both sides of a distal portion of the guide main body.

Abstract: Provided is an inexpensive microneedle array with little dimensional error that can control, with high precision, the amount of a predetermined component to be introduced to the inner part of the skin, and a production method for this microneedle array. A foundation that is insoluble or sparingly soluble in inner part of the skin is overlaid on a mold. A plurality of frustum-shaped protrusions, which are insoluble or sparingly soluble in the raw material liquid, provided on a first main surface of the foundation are fit into a plurality of cone-shaped recesses. The raw material liquid in the plurality of cone-shaped recesses dries and, as a result, a plurality of microneedles, which are dissolvable in the inner part of the skin, are fixed to tip surfaces of the plurality of frustum-shaped protrusions.

Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

Abstract: A microneedle structure, a manufacturing method therefor, and a manufacturing apparatus therefor are presented. The microneedle structure manufacturing method according to one embodiment of the present invention comprises the steps of: a) injecting, into a lower mold comprising a microneedle intaglio, a polymer solution containing a biocompatible polymer; and b) coupling a shape control mold, which comprises a protrusion, to the lower mold such that one end of the protrusion of the shape control mold is impregnated with the biocompatible polymer solution injected into the microneedle intaglio.

Abstract: The present disclosure relates to an insertion type drug injection device capable of being inserted into a body for injecting a drug into a skin, including: a main body having an open insert part and formed in a tubular shape having a hollow space therein, a needle assembly formed in the insert part, provided with a plurality of needles, and including a pneumatic port and a drug injection port, and a drug injection pipe inserted into the main body and connected to a drug injection port of the needle assembly, and an air flowing pipe connected to the pneumatic port.

Abstract: Provided are a manufacturing method of a plate precursor having a plurality of needle-like protrusions and a manufacturing method of a microneedle array, which make it possible to manufacture a plate precursor within a short period of time. A manufacturing method of a plate precursor having a needle-like protrusion includes: a preparation step of preparing a cutting tool including at least one blade conforming to an external shape of the needle-like protrusion, and a base material; and a cutting step of cutting the base material by rotating the cutting tool about a tool axis of the cutting tool and revolving the cutting tool around an axis of the needle-like protrusion to be formed on the base material to form the needle-like protrusion having a shape conforming to a shape of the cutting tool.

Abstract: An injector includes an injector housing, an activation button assembly translatable from an unactuated position to an actuated position and a cartridge door movably mounted to the injector housing between an open position and a closed position. A deflectable interference member has a resting position configured to limit an insertion depth of a cartridge into an interior channel of the cartridge door to a sealed position, wherein the cartridge piercing needle does not fully penetrate a pierceable septum of the cartridge. Movement of the activation button assembly from the unactuated position to the actuated position thereof, in the closed position of the cartridge door, deflects the interference element out of the resting position thereof, thereby enabling further advancement of the cartridge into the interior channel of the cartridge door to an unsealed position, wherein the cartridge piercing needle fully penetrates the pierceable septum.

Abstract: A method of forming a chemical delivery device with an active chemical includes generating halftoned image data using a stochastic halftone screen and with reference to a concentration parameter for the active chemical. The method also includes ejecting a chemical carrier including the active chemical into a portion of a plurality of cavities formed in the chemical delivery device based on the halftoned image data to produce the chemical delivery device with a concentration of the active chemical corresponding to the concentration parameter.

Abstract: A production method of a mold having a recessed pattern includes: a plate precursor preparation step of preparing a plate precursor having a pedestal on which a protruding pattern is disposed; a resin plate preparation step of preparing a thermoplastic resin plate having a recessed step portion; and a resin plate precursor production step of producing a thermoplastic resin plate precursor, the resin plate precursor production step including a positioning step of positioning the protruding pattern of the plate precursor and a center position of the recessed step portion, and a recessed pattern forming step of forming a recessed pattern having an inverted shape of the protruding pattern on the thermoplastic resin plate by pressing the protruding pattern of the heated plate precursor and the pedestal against the recessed step portion, thereafter cooling the plate precursor, and separating the plate precursor from the thermoplastic resin plate.

Abstract: A smart patch and a method for fabricating the same are provided. The smart patch includes: a substrate, a detecting component arranged on the substrate, and a reminding component connected with the detecting component, wherein the detecting component is configured to detect a stretch degree of the substrate; and the reminding component is configured to transmit a reminding signal when the stretch degree of the substrate, detected by the detecting component, meets a preset condition.

Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Abstract: Provided herein are an injection device and a method of injecting a patient. The injection device includes a base portion including a body section and a control section, at least one bracket secured to the body section, an articulation element secured to the control section, and a pusher plate coupled to the articulation element, wherein the articulation element moves the pusher plate with respect to the base portion. The method includes positioning at least two syringes in the injection device, placing an injection end of the injection device in contact with an injection site on the patient, and activating the articulation element, wherein activating the articulation element moves the pusher plate towards the at least two syringes, depressing a plunger and dispensing a fluid from the at least two syringes.

Abstract: The present invention relates to a method of manufacturing a microstructure, including: (a) forming a solid on a substrate; (b) fluidizing the solid by adding a solvent thereto; and (c) shaping the fluidized solid, and a microstructure manufactured using the method.

Abstract: An apparatus for removing blackheads and providing skin care treatments comprising a funnel body that comprises a compartment, a first opening and a second opening that are bended about 45 degrees from an axial axis. The first opening further comprises a vacuum tip that is detachable and the second opening further comprises a massage metal plate. The apparatus further comprises a vacuum pump, a CPU, and a PCB. The vacuum tip further comprises a vacuum filter. The funnel body further comprises a smart switch disposed on the outside wall thereof. The apparatus further comprises a lithium battery. The funnel body further comprises vent pores. The apparatus further comprises a status light made of LED.

Abstract: The purpose of the present invention is to provide a microneedle array and a microneedle manufacturing method, which improves medical solution delivery efficiency and facilitates manufacturing. The microneedle array is provided with a first divisional element, a second divisional element to be bonded to the first divisional element, a longitudinal passage formed between the first divisional element and the second divisional element bonded to each other; and a horizontal hole, having an orifice on a lateral side and formed in a direction parallel to a bonding surface of the first divisional element with the second divisional element, and communicating to the longitudinal passage.

Abstract: An attachable needle assembly (2) is disclosed for use on a medication delivery pen (4). The needle assembly (2) includes a housing (8) enclosing a hub (12) that is configured to engage the medication delivery pen (4), a plurality of needles (18) configured to pierce a reservoir septum (6) of the medication delivery pen (4), a selection ring insert (30) that rotates and identifies which needle (24) of the plurality of needles (18) is to be selected, and a selection ring (36) that applies a force to expose the selected needle (24). When the housing (8) is in a first position, the plurality of needles (18) is not exposed, and when the housing (8) is in a second position, one of the plurality of needles (24) is exposed for medicament delivery.

Abstract: The invention relates to a valve, in particular for a device for administering a liquid medicament, with a valve body which has an interior for receiving a liquid, wherein the valve body has a liquid inlet and an opposite liquid outlet which both open into the interior, wherein the interior accommodates a large number of micro channels which extend in a connection direction between the liquid inlet and the liquid outlet. A corresponding device for administering a liquid medicament is also described.

Abstract: A needling device may be used for needling of a subject's skin, and a drug applicator device may be used for applying a drug to a subject's skin. For example, a needling device may be applied to a subject's skin for hair growth applications, or may be used for wrinkle, scar, or tattoo removal. A drug applicator device may be used for multiple drug application purposes such as applying a hair growth compound to the skin of a subject.

Abstract: A uniformity control membrane can be securely engaged against an upstream side of a microneedle array and configured so that resistance to flow through the uniformity control membrane is substantially greater than the resistance to flow through the microneedle array. These differences in flow resistance can facilitate uniform administration of a liquid formulation into the patient's skin across a broad area and at a relatively low pressure, such as by way of capillary action. The administration of the liquid formulation into the patient's skin across the broad area can result from the liquid formulation being administered by way of at least a majority of the microneedles of the microneedle array.

Abstract: The purpose of the present application is to provide a microneedle patch applicator and a microneedle patch applicator housing, whereby perpendicular penetration properties of the needle into skin are enhanced. A microneedle patch applicator housing has a flat peripheral base part configured from a single sheet or film, and a protruding part which is surrounded by the peripheral base part and bulges perpendicularly upward toward a top surface from a bottom surface with respect to the peripheral base part. A bottom-surface portion of the protruding part constitutes part of a microneedle patch support surface. The protruding part is provided with a plurality of recessed fold parts, and the recessed fold parts have recess bottoms oriented in the direction away from a center part of the protruding part.

Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.

Abstract: The present invention provides a fine hollow protruding tool (1) having a basal member (2) and a fine hollow protrusions (3) project from the basal member (2). The fine hollow protrusions (3) each has an opening portion (3h) on a tip side thereof and an interior in which an interior space linked to the opening portion (3h) is formed. In any vertical cross-section passing through an apex of the fine hollow protrusion (3), a wall thickness (T1) in an apex-side region (TB) on the apex side is thinner than a wall thickness (T2) in a lower-side region (BP) that is closer to the basal member (2) than the apex-side region (TB) is, and a gap (M1c) between inner walls (31) in the apex-side region (TB) is smaller than a gap (M2c) between the inner walls (31) in the lower-side region (BP). A base portion (34) of the fine hollow protrusion (3) projecting from the basal member (2) has a curvature.

Abstract: An attachable needle assembly (2) for use on a medication delivery pen (4), the needle assembly (2) comprising a housing (10) enclosing a spike housing (8) configured to (a) engage the medication delivery pen (4), and (b) pierce a reservoir septum (6) of the medication delivery pen (4), a communication septum (72, 76) of the needle assembly (2) defining a septum chamber (80, 82), the septum chamber (80, 82) being in fluid communication with the spike housing (8), a plurality of needles (18) disposed in the communication septum (72, 76), a selection ring insert (30) that rotates and identifies a needle (24) of the plurality of needles (18), and a selection ring (36) exposes the selected needle (24) and moves the selected needle (24) into fluid communication with the septum chamber (80, 82), wherein when the housing (10) is in a first position, the plurality of needles (18) is not exposed, and when the housing (10) is in a second position, one of the plurality of needles (24) is in fluid communication with the

Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.

Abstract: To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient. The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass %, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass %, a surfactant is 0.05 to 5 mass %, and a water-soluble polyalcohol is 10 mass % or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.

Abstract: An attachable needle assembly (2) for use on a medication delivery pen (4), the needle assembly (2) comprising a spike housing (8) that is configured to engage the medication delivery pen (4) and pierce a reservoir septum (6) of the medication delivery pen (4), a needle assembly housing (22) secured to the spike housing (8), the needle assembly housing (22) enclosing a septum (40) with a cavity (42) that is in continuous fluid communication with the spike housing (8), and a plurality of needles (44) configured to pierce the needle assembly septum (40), wherein when the needle assembly housing (22) is in a first position, the plurality of needles (44) are disengaged from the needle assembly septum (40), and when the needle assembly housing (22) is in a second position, one of the plurality of needles (46) enters into fluid communication with the septum cavity (42) and is exposed for medicament delivery.

Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.

Abstract: An attachable needle assembly (2) used on a medication delivery pen (4), the needle assembly (2) comprising a spike (9) configured to pierce a vial, reservoir or cartridge septum of the pen (4), a needle guide (12) configured to mate with the pen (4), the needle guide (12) enclosing a septum (22) of the needle assembly (2) defining a septum chamber (31), the septum chamber (31) being in fluid communication with the spike (9), a plurality of needles (34) disposed in the septum (22) of the needle assembly (2), a sterility barrier (60) enclosing each of the plurality of needles (34), each of a plurality of sterility barriers (60) having a peel tab (70), each of a plurality of peel tabs (70) being wrapped around the needle guide (12), wherein when one of the plurality of needles (40) is drawn from the needle guide (12) from a first position to a second position, the needle (40) fluidly communicates with the septum chamber (31), and the sterility barrier (60) and the peel tab (70) of the needle (40) are removed.

Abstract: This invention describes compositions comprising indocyanine green and poly(N-vinylpyrrolidone) and methods of making the same as well as applications thereof for diagnostic and therapeutic uses. One of those applications is the structural and functional assessment of the lymphatic system by fluorescence imaging.

Abstract: An attachable needle assembly (2) used on a medication delivery pen (4), the needle assembly (2) comprising a communication needle (10) configured to pierce a reservoir septum of the medication delivery pen (4), a spike housing (8) surrounding the communication needle (10) and configured to engage the medication delivery pen (4), a selector ring (16), including a selector opening (18), enclosing a septum (22, 30) of the needle assembly (2) defining a septum chamber (28, 29) that is in fluid communication with the communication needle (10), a plurality of needles (34) disposed in the septum (22, 30) of the needle assembly (2), and a peel tab (60) enclosing each of the plurality of needles (34), wherein the selector opening (18) is aligned with a selected peel tab (60) corresponding to a selected needle (40), the selected peel tab (60) is drawn out of the selector ring (16) and moves the selected needle (40) from a first position to a second position, and the selected needle (40) enters into fluid communication

Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.

Abstract: Disclosed is a microneedle for dental material delivery, the microneedle including a needle body portion; an active ingredient coating portion configured to coat the surface of the needle body portion, and including an active ingredient transferred to the skin tissue within a mouth; and a base portion configured to couple with the needle body portion, and to bend along a skin shape within the mouth, wherein the base portion includes at least one of polyethylene (PE), polypropylene (PP), polytetrafluoroethylene (PTFE), polymethylmethacrylate (PMMA), ethylene vinyl acetate (EVA), polycaprolactone (PCL), polyurethane (PU), polyethylene terephthalate (PET), polyethylene glycol (PEG), polyvinyl alcohol (PVA), poly lactide (PLA), poly lactic-co-glycolic acid (PLGA), and polyglycolide (PGA).

Abstract: An attachable needle assembly (102) for use on a medication delivery pen (104), the needle assembly (102) comprising a housing (1 10) enclosing a hub (106) having a communication needle (108) configured to engage the medication delivery pen (104) and pierce a reservoir septum of the medication delivery pen (104), a communication septum (172, 176) of the needle assembly (102) defining a septum chamber (180, 182) that is in fluid communication with the communication needle (108), a plurality of needles (118) disposed in the communication septum (172, 176), a follower ring (130) that determines which needle (124) of the plurality of needles (118) is to be selected, and a snap ring (136) that exposes the selected needle (124) and moves the selected needle (124) in fluid communication with the septum chamber (180, 182), wherein when the housing (110) is in a first position, the plurality of needles (118) is not exposed, and when the housing (110) is in a second position, the selected needle (124) is in fluid commu

Abstract: Discloses is a method of manufacturing a micro-needle. The method includes a step of preparing a medicinal solution, a step of forming a plurality of tips with the medicinal solution, and a step of forming a cavity in each of the tips. In accordance with such a configuration, a micro-needle in which cavities are formed is provided, whereby it is possible to administer a fixed amount of medicine in a short time.

Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.

Abstract: A plurality of projections in a transdermal administration device each include a columnar portion extending from a first surface of a substrate, and a tapered portion extending from a top of the columnar portion. A maximum angle of an apex of the tapered portion viewed in a direction parallel with the first surface is in a range of 10° or more and 30° or less, a ratio of a length from a proximal end to a distal end of the tapered portion to a length from a proximal end to a distal end of the projection as viewed in a direction perpendicular to the first surface is in a range of 0.45 or more and 0.75 or less, and a pitch (distance between centers of closest projections), viewed in a direction perpendicular to the first surface is in a range of 50 ?m or more and 350 ?m or less.

Abstract: A multi-needle assembly for cosmetic procedure includes a main body having an inner space extending from one end to another, a reciprocating member provided in the main body, a needle member placed into the reciprocating member and having a plurality of needles that enter or exit through the one end of the main body, a guide suction into or from which the plurality of needles enter or exit, and length adjusting grooves for moving the reciprocating member in a forward and backward direction.

Abstract: A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques.