Injection Or Aspiration Device Having Plural Body Entering Conduits Patents (Class 604/173)
  • Patent number: 10751484
    Abstract: A needle injection array can comprise a plurality of needles that are fluidly interconnected via a fluid manifold. The fluid manifold can be configured to direct fluid from a syringe to arrive at tips of the needles approximately simultaneously. The fluid manifold also be configured to provide approximately equal dosage or fluid volume through each of the needles to an injection site.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 25, 2020
    Assignee: Allergan Industrie, SAS
    Inventor: Bastien Mandaroux
  • Patent number: 10737081
    Abstract: The present invention relates to a painless and patchless shooting microstructure, and a microstructure shooting device. According to the present invention, it is possible to inject a microstructure into the skin within the time of less than one second, and the inconvenience of waiting for the decomposition of a microstructure and removing a patch are completely overcome. A patch-type conventional technology has a problem wherein it is difficult to be applied to a region having hair, but the present invention completely overcomes this problem. According to the present invention, it is possible to precisely control the permeation depth of a microstructure into the skin by controlling discharge power.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 11, 2020
    Assignee: JUVIC INC.
    Inventors: Hyung Il Jung, Shayan Fakhraeli Lahiji
  • Patent number: 10716924
    Abstract: Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: July 21, 2020
    Assignee: SRGI HOLDINGS, LLC
    Inventor: Edward Knowlton
  • Patent number: 10688242
    Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: June 23, 2020
    Assignee: AngioDynamics, Inc.
    Inventors: Bradley D. Chartrand, Raymond Lareau, Daniel Buehner, Tobin Kovoor, Brian Nentwick
  • Patent number: 10667830
    Abstract: Device for safely and precisely causing micro-injuries to the dermis to stimulate collagen production a skim remodeling. Specifically, needles on the device pierce the epidermis and basal cell layer into the dermis. The device incorporates safety features for the operator to be able to operate the device with one hand while keeping the other had free during procedures. Additionally, the device incorporates single use safety controls to help prevent cross contamination between patients.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: June 2, 2020
    Assignee: BELLUS MEDICAL, LLC
    Inventors: Joseph Proctor, Tanzeel Ur Rahman, Ronald J Hegler, David J Lapeus, James Mullner
  • Patent number: 10639823
    Abstract: A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus of a microneedle-array manufacturing apparatus is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus can align the relative position of the droplet-delivery apparatus and a mold such that the droplets from the droplet-delivery apparatus are caused to land in each of the recessed parts. The droplet-delivery apparatus delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 5, 2020
    Assignees: NISSHA PRINTING CO., LTD., BIOSERENTACH CO., LTD.
    Inventors: Shinya Yamada, Masateru Chiyama, Kensaku Akita, Takako Ueno, Yuko Ide, Sachi Nagai, Osanobu Akao, Ichiro Ono, Kanji Takada
  • Patent number: 10632065
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 28, 2020
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., ASKA PHARMACEUTICAL CO., LTD.
    Inventors: Shinpei Nishimura, Seiji Tokumoto, Takeshi Ito, Hajime Asada
  • Patent number: 10553502
    Abstract: A system and method for performing a wet etching process is disclosed. The system includes multiple processing stations accessible by a transfer device, including a measuring station to optically measure the thickness of a wafer before and after each etching steps in the process. The system also includes a controller to analyze the thickness measurements in view of a target wafer profile and generate an etch recipe, dynamically and in real time, for each etching step. In addition, the process controller can cause a single wafer wet etching station to etch the wafer according to the generated etching recipes. In addition, the system can, based on the pre and post-etch thickness measurements and target etch profile, generate and/or refine the etch recipes.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: February 4, 2020
    Assignee: VEECO PRECISION SURFACE PROCESSING LLC
    Inventors: Laura Mauer, John Taddei, John Clark, Elena Lawrence, Eric Kurt Zwirnmann, David A. Goldberg, Jonathan Yutkowitz
  • Patent number: 10471245
    Abstract: A method of manufacturing a needle-shaped body includes forming a needle-shaped body precursor such that the needle-shaped body precursor has a base portion and a needle-shaped portion on the base portion, and that the needle-shaped portion has a portion which contacts the base portion and has a form of a polygon, producing a needle-shaped body original plate by forming a curved surface portion in at least a portion of an apex portion of the polygon in a junction portion at a boundary between the base portion and the needle-shaped portion, producing a resin plate by transfer molding with the needle-shaped body original plate such that the resin plate has a concave pattern corresponding to the needle-shaped portion and the curved surface portion, and producing a needle-shaped body by transfer molding with the resin plate such that the needle-shaped body has a transferred needle-shaped portion and a transferred curved surface portion.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: November 12, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventor: Daizo Uemura
  • Patent number: 10463608
    Abstract: A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: November 5, 2019
    Assignee: THE CORPORATION OF MERCER UNIVERSITY
    Inventor: Martin J. D'Souza
  • Patent number: 10456569
    Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 29, 2019
    Assignee: FUJIFILM Corporation
    Inventor: Satoshi Wakamatsu
  • Patent number: 10441532
    Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 15, 2019
    Assignee: FUJIFILM Corporation
    Inventor: Satoshi Wakamatsu
  • Patent number: 10384045
    Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Parminder Singh
  • Patent number: 10293149
    Abstract: A multi-site injection system includes a plurality of medicament delivering needles/microprotrusions, a needle/microprotrusion support, a supply of medicament, and a mechanism for providing the medicament to the plurality of needles/microprotrusions in order to effect delivery into a stratum corneum of a user.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 21, 2019
    Assignee: Allergan, Inc.
    Inventors: Steven D. Kimmell, Scott J. Gerondale
  • Patent number: 10293088
    Abstract: Systems and methods are provided for moving fluids from a patient to a canister and lowering or eliminating the bio-burden of the canister. In one instance, a method for removing fluids from a patient includes using reduced pressure to remove fluids from a patient, delivering the fluids into a reduced-pressure conduit and into a fluid reservoir, exposing the fluids removed from the patient to a UV light source to kill pathogens to create disposable fluids, and disposing of the disposable fluids. Other systems, devices, and methods are presented.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 21, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson
  • Patent number: 10285718
    Abstract: A catheter system includes a shaft main body having a rotation axis lumen including a rotation central axis, a revolving lumen that revolves around the rotation axis lumen when the shaft main body is rotated about the rotation central axis, a side-by-side portion in which at least a portion of the rotation axis lumen and at least a portion of revolving lumen exist in side-by-side relationship, and a branch part at which the revolving lumen branches off from the side-by-side portion on a distal side relative to the branch part. The revolving lumen on the distal side relative to the branch part is formed of a distal shaft which has a proximal-side bending portion that bends in such a direction as to become farther away from the rotation axis lumen in radial direction and an opening that communicates with the revolving lumen.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: May 14, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Yuuki Masubuchi
  • Patent number: 10130379
    Abstract: Embodiments of the invention include a multi-lumen catheter for extracting or aspirating a blood clot or thrombus from arterial or veinous sites. Other embodiments are also included herein.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 20, 2018
    Assignee: NorMedix, Inc.
    Inventors: Jeffrey M. Welch, Karl V. Ganske, Gregg Stuart Sutton
  • Patent number: 10098834
    Abstract: The present invention provides methods and kits for preventing, treating or delaying various cardiovascular diseases or disorders especially heart failure by extended release of neuregulin to a mammal. Moreover, the extended release of neuregulin is administered by subcutaneous infusion with a pump.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 16, 2018
    Assignee: Zensun (Shanghai) Science & Technology, Co., Ltd.
    Inventor: Mingdong Zhou
  • Patent number: 10086183
    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 2, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shunsuke Arami, Shinpei Nishimura, Seiji Tokumoto, Makoto Ogura
  • Patent number: 10085943
    Abstract: Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 2, 2018
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Po-Jung Chen, Mao-Chi Weng, Mei-Hui Wang, Chien-Chung Hsia
  • Patent number: 10076354
    Abstract: Systems, instruments or devices, and methods or procedures are described in which a scalpet array is applied to a target site with the use of a pattern. The scalpet array comprises scalpets positioned on a device. Skin pixels are incised at the target site via application of a load through the scalpet array. A recipient site is prepared by positioning the pattern at the recipient site and applying the scalpet array to generate skin defects. The incised skin pixels are applied at the skin defects of the recipient site.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: September 18, 2018
    Assignee: SRGI HOLDINGS, LLC
    Inventor: Edward Knowlton
  • Patent number: 9993423
    Abstract: The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same. The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 12, 2018
    Assignee: COSMED PHARMACEUTICAL CO., LTD.
    Inventors: Ying-shu Quan, Fumio Kamiyama
  • Patent number: 9974935
    Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 22, 2018
    Assignee: MEDRX CO., LTD.
    Inventors: Kiyotsuna Toyohara, Taishi Tanaka, Kazuteru Kohno, Takashi Oda, Koichi Masaoka, Katsunori Kobayashi, Masaki Ishibashi, Hidetoshi Hamamoto
  • Patent number: 9968766
    Abstract: To provide a transdermal absorption sheet with which control of a dissolution rate and suppression of drug diffusion can be achieved, and a method of manufacturing the transdermal absorption sheet. A transdermal absorption sheet 100 is provided with a sheet portion 116, a plurality of frustum portions 114 that is disposed on the sheet portion 116, and needle portions 112 that are disposed on the frustum portions 114, each of the plurality of needle portions 112 includes a first layer 120 containing a drug and a second layer 122 not containing a drug, and at least one of the plurality of needle portions 112 contains an air bubble 124.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 15, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Satoshi Wakamatsu, Koki Kabata
  • Patent number: 9801920
    Abstract: The present invention relates to an antimicrobial composition derived from a natural substance. Since the composition effectively suppresses Filobasidium, an organism that has been newly identified as causing dandruff, the present invention can effectively prevent and/or treat seborrhoeic dermatitis and dandruff. Also, since the antimicrobial composition of the present invention includes a natural substance as an active ingredient, little consumer aversion will result. Also, it is expected that the antimicrobial composition of the present invention can be used for developing an antidandruff agent having a reduced content of materials which are typically used as antidandruff agents and the safety of which is questionable.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: October 31, 2017
    Assignee: Chung-Ang Univ Industry-Academic Coop. Foundation
    Inventors: Won Yong Kim, Sang Gue Park, Hee Kuk Park
  • Patent number: 9795774
    Abstract: A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: October 24, 2017
    Assignees: BIOSERENTACH CO., LTD., LABO JUVERSA CO., LTD.
    Inventors: Kanji Takada, Ichiro Ono
  • Patent number: 9731104
    Abstract: A dual reservoir access port includes a base having proximal and distal fluid reservoirs. The fluid reservoirs each comprise a bottom and a side wall. A dual prong outlet stem projects from a distal end of the base and comprises a first prong and a second prong. A first fluid channel extends through the first prong to the distal reservoir, and a second fluid channel extends through the second prong to the proximal fluid reservoir. A puncture shield is disposed between at least a portion of the second fluid channel and the bottom of the distal fluid reservoir. A needle-penetrable septum is disposed atop of each of the fluid reservoirs. A cap is placed over and around the port base compressing and sealing the septa against the base. A locking collar may be placed over a dual lumen catheter to lock the catheter to the dual prong outlet stem.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: August 15, 2017
    Assignee: Medical Components, Inc.
    Inventors: Christopher Linden, Raymond Bizup, Cristian M. Ciuciu
  • Patent number: 9717861
    Abstract: A syringe (211) includes a syringe body (217) for receiving and administering a medicament. A needle (215) is received by the syringe body (217). A needle adjusting member (221) is movably disposed on the syringe body (217) between first and second positions. When the needle adjusting member (221) is in the first position, the needle (215) has a first length adapted to draw medicament into the syringe body (217). When the needle adjusting member (221) is in the second position, the needle (215) has a second length for injecting the medicament.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 1, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Robert Banik, James Bates
  • Patent number: 9717451
    Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: August 1, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
  • Patent number: 9707339
    Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: July 18, 2017
    Inventors: Bradley D. Chartrand, Raymond Lareau, Daniel Buehner, Tobin Kovoor, Brian F. Nentwick
  • Patent number: 9687640
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Patent number: 9681860
    Abstract: The present invention relates to a halo spray tip atomizer device primarily suited for the application of the fibrin glues. The device offers way to transition seamlessly between a static delivery device and an atomization device. The device is also so configured as to limit possible clogging.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: June 20, 2017
    Inventor: Dennis L Steffen
  • Patent number: 9649281
    Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 16, 2017
    Assignee: FUJIFILM Corporation
    Inventors: Junya Yoshida, Seiji Kasahara, Takayoshi Oyamada, Yanlong Che
  • Patent number: 9636490
    Abstract: A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 ?m and satisfying the expression H/D?5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: May 2, 2017
    Assignee: MEDRX CO., LTD.
    Inventors: Koichi Masaoka, Keizo Ikari, Takashi Oda, Katsunori Kobayashi, Hidetoshi Hamamoto, Masaki Ishibashi, Kiyotsuna Toyohara
  • Patent number: 9603795
    Abstract: A composite for preparing a transdermal delivery device and a method for synthesizing the composite thereof comprising at least one polymer and at least one macrocyclic molecule, wherein the at least one polymer and the at least one macrocyclic molecule are adapted to form a complex.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: March 28, 2017
    Assignee: City University of Hong Kong
    Inventors: Wei Chen, Xianfeng Chen
  • Patent number: 9566216
    Abstract: A bone cement formulation comprising: (a) magnetic calcium phosphate nanoparticles present in an amount of 5.0-95 wt. % and having a largest linear dimension of 150 nm to 50 microns; (b) polymerizable acrylate monomer present in an amount of 5.0-95 wt. %; and (c) polyacrylate polymer present in an amount of 0-80 wt. % and having a largest linear dimension from 5.0 to 500 microns. Upon exposure to an alternating magnetic field the formulation is heated which results in polymerization of the acrylate monomer component. The formulation may also be polymerized via the use of chain polymerization initiators.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 14, 2017
    Assignee: SOUTHWEST RESEARCH INSTITUTE
    Inventors: Xingguo Cheng, Daniel P. Nicolella, Todd L. Bredbenner
  • Patent number: 9561355
    Abstract: There is described a method for making an array of micro-needles, comprising the steps of: depositing a plurality of drops of a liquid substance comprising a polymer on a surface of a starting substrate; positioning a pyroelectric substrate at a certain distance from the starting substrate in such a way that the drops deposited are positioned between said surface of the starting substrate and a surface of the pyroelectric substrate; varying the temperature of the pyroelectric substrate or a part thereof to induce on said surface of the pyroelectric substrate a charge density such that starting from the drops deposited, under the effect of an electrodynamic force, respective cones are formed having a tip facing towards the pyroelectric substrate; determining a consolidation of the cones, to form said micro-needles, preventing the tip of said cones from contacting said surfaces of the pyroelectric substrate.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: February 7, 2017
    Assignees: CONSIGLIO NAZIONALE DELLE RICERCHE, FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
    Inventors: Pietro Ferraro, Sara Coppola, Andrea Finizio, Simonetta Grilli, Veronica Vespini, Paolo Antonio Netti, Raffaele Vecchione, Eliana Esposito
  • Patent number: 9492647
    Abstract: A microneedle array applicator is configured to apply a microneedle array in cosmetic and medical applications. The microneedle array applicator has a holding apparatus configured to define detachable holding of a microneedle array comprising a planar substrate. The microneedle array applicator also has a drive mechanism for driving the microneedle array in a first direction perpendicular to the planar substrate and in a second direction parallel to the planar substrate. A method for applying a microneedle array includes the microneedle array applicator enabling safe breaking off of the microneedles, optionally laden with an active ingredient, in the skin.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 15, 2016
    Assignee: Robert Bosch GmbH
    Inventors: Michael Stumber, Martina Daub
  • Patent number: 9474847
    Abstract: A microenvironment of a biological body is controlled, and more particularly, is measured, changed, and monitored with respect to temperature, pH level, moisture and other tissue parameters of a region of the body while, optionally, administering a therapeutic agent to that region.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: October 25, 2016
    Assignee: P Tech, LLC
    Inventors: Peter M. Bonutti, Justin E. Beyers
  • Patent number: 9381336
    Abstract: The application relates to a device for repeated puncturing of the skin, with a housing, a drive device, which is accommodated in the housing and configured to provide a driving force, a coupling mechanism, which is accommodated in the housing, and a piercing device, which via the coupling mechanism driving force for a repetitive piercing movement is coupled to the piercing device, and the piercing device includes a base having a thereto formed distal active area, over which a plurality of spaced piercing elements are distributed, and where the base with the thereto formed distal active surface is mounted relative to the housing can be tilted. Furthermore, the application relates to a piercing module for a device for repeated puncturing of the skin.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: July 5, 2016
    Assignee: MT.DERM GMBH
    Inventor: Christian Reinhold Jarling
  • Patent number: 9192750
    Abstract: Methods and devices for administration of substances into at least two compartments of skin for systemic absorption and improved pharmacokinetics, based on biphasic or bimodel kinetic profiling.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: November 24, 2015
    Assignee: Becton, Dickinson and Company
    Inventors: Ronald J. Pettis, Noel Harvey, Barry Ginsberg
  • Patent number: 9144450
    Abstract: The present description relates to fluid sealant compositions that increase in viscosity upon administration to a subject, to medical procedures employing such compositions, to methods for administering such compositions, and to products containing such compositions including medical devices, medical device components and kits, among other aspects.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: September 29, 2015
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Kevin L. Newell, Christopher Oskin
  • Patent number: 9044582
    Abstract: An apparatus for transdermal fluid delivery includes a handle and a tip, having a skin applying surface, being driven to move by a driving unit. A fluid delivery structure has an aperture formed at the skin applying surface and a vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip. A flow of fluid is delivered onto the skin applying surface through the fluid delivery structure to interact with the abrading elements and the electrodes before the fluid is returned and collected, so that three different skin treatments of abrasive peeling, electrical stimulation, and liquid infusion are achieved in one single structure for improving a skin structure.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: June 2, 2015
    Inventors: Franklin J. Chang, Henry Ping Chang
  • Publication number: 20150141956
    Abstract: An injection device for injecting a medicant into a plurality of tissue sites in a patient for a selected treatment is constructed and arranged such that the number of tissue sites is the total number for the selected treatment thereby requiring a single positioning step. The injection device includes a body having a syringe and a control linkage, the syringe including a plurality of barrels, and a cooperating plunger array including a plurality of plungers. Each barrel receives a corresponding plunger. The injection device further includes a plurality of injection needles connected to the syringe wherein one injection needle is connected to each barrel, a multi-lumen tip, a shaft connected to the multi-lumen tip and extending between said multi-lumen tip and said body. The control linkage is connected to each needle so as to move each needle between a deployed injection position and a retracted position.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Grant T. Hoffman, Robert Eells, Wen Hong Neoh, Jeffry S. Melsheimer
  • Publication number: 20150141924
    Abstract: A novel array of hollow silica glass microneedles is provided. The array is prepared from a silica dispersion. A novel apparatus is provided comprising a negative mold component having tapered openings therein and a positive mold component having positive elements that are received within the tapered openings of the negative mold component. An assembly is prepared of the negative mold component and the positive mold component, with an aqueous silica dispersion received within the space between the outer surface of the positive elements and the inner surface of the openings. The assembly is heated to remove air and water vapors from the silica dispersion, then the assembly is further heated to sinter the remaining silica to silica glass. The sintered silica glass when removed from the mold components is in the form of an array of microneedles.
    Type: Application
    Filed: May 10, 2013
    Publication date: May 21, 2015
    Inventor: Robert M. Pricone
  • Publication number: 20150141776
    Abstract: A subcutaneous access device has a skin attachment plate coated with an adhesive layer. The skin attachment plate is moveably linked by a retraction mechanism to a needle support with fixedly positioned needles. In the ready-to-use position the skin attachment plate is spaced away from the needle support and covers the fixedly positioned needles. Subcutaneous insertion of the needles is effected by attachment of the skin attachment plate with the adhesive layer to the skin and releasing the retraction mechanism, thus triggering the pulling of the attached skin with high velocity against the tip of the needles.
    Type: Application
    Filed: April 8, 2013
    Publication date: May 21, 2015
    Inventors: Paul Hadváry, Hansjörg Tschirky
  • Publication number: 20150141954
    Abstract: A device for inserting at least one hollow needle for the injection or withdrawal of a solution into/from a tissue, said device comprising a casing (1), a plunger (2) movably mounted inside the casing, and propulsion means (3 and 4) suitable for driving the plunger towards the distal end (1a) of the device by applying a force F1(t). The propulsion means and/or the plunger comprise retaining means (3a) for joining the propulsion means and the plunger while the latter is moving, said retaining means releasing the plunger from the propulsion means when a force F2(t) is exerted in the opposite direction to F1(t). Pressure means hold the needle in the tissue and allow a controlled withdrawal of the plunger at least while the solution is being injected.
    Type: Application
    Filed: May 8, 2013
    Publication date: May 21, 2015
    Inventors: Jérôme Da Ros, Frédéric Neftel
  • Publication number: 20150133866
    Abstract: An operation tool includes a mechanism sequentially moving the injector in a space of an outer cylinder among an initial position in which needles of a main body of the device are retracted inside the space, a first position in which the needles protrude to the outside by a first distance, and a second position in which needles protrude to the outside by a second distance shorter than the first distance. Fluid flows from the injector through the needles in the second position. The mechanism has a unit forcing the injector toward the initial position by a magnetic force, first and second stoppers which can be selectively extended/retracted with respect to the outer peripheral wall of the outer cylinder, and an engaging portion which is selectively engaged with these stoppers on the outer peripheral wall of the injector and selectively arranging the injector in the above three positions.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 14, 2015
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Tomoya SUMIDA, Yumiko IKEDA, Masaki KONO
  • Patent number: 9028463
    Abstract: The present invention provides a method for enhancing the immunogenicity using a microneedle device capable of enhancing the immunogenicity of an influenza vaccine. According to the method for enhancing the immunogenicity using the present microneedle device, a microneedle device having microneedles made of polylactic acid, coated with an influenza vaccine composed of an antigen having type A strain (H1N1), type A strain (H3N2), and type B strain as active ingredients is brought into direct contact with the skin so as to transcutaneously administer the aforementioned influenza vaccine. After the transcutaneous administration, lauryl alcohol is applied to the site of the skin where the microneedle device has been brought into direct contact.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: May 12, 2015
    Assignees: Hisamitsu Pharmaceutical Co., Inc., The Chemo-Sero-Therapeutic Research Institute
    Inventors: Chikateru Nozaki, Kazuyoshi Kaminaka, Junichi Matsuda, Takaaki Terahara, Tetsuji Kuwahara, Seiji Tokumoto
  • Publication number: 20150126937
    Abstract: The present invention relates to a self-injection mechanism that causes a solution (2) having predetermined efficacy to permeate the skin (1) for skin improvement and beauty treatment. The present invention includes: an accommodation unit (10) having a space (11) therein for accommodating the solution (2), an inlet (12) which sucks only air at one end, and an outlet (15) which is open so that the solution (2) is discharged at the other end; a pumping unit (20) coupled to the outlet (15) of the accommodation unit (10) so as to be in communication with the same, having an airless pump (21) which discharges the solution (2) by an up and down movement at the center; and an injection unit (30) coupled with the airless pump (21) of the pumping unit (20) so as to be in communication with the same, causing the solution (2) which is discharged by the up and down movement to permeate the skin (1).
    Type: Application
    Filed: January 24, 2013
    Publication date: May 7, 2015
    Inventor: Ji Young Chang