Injection Or Aspiration Device Having Plural Body Entering Conduits Patents (Class 604/173)
  • Patent number: 11071833
    Abstract: An attachable needle assembly (2) for use on a medication delivery pen (4), the needle assembly (2) comprising a housing (10) enclosing a spike housing (8) configured to (a) engage the medication delivery pen (4), and (b) pierce a reservoir septum (6) of the medication delivery pen (4), a communication septum (72, 76) of the needle assembly (2) defining a septum chamber (80, 82), the septum chamber (80, 82) being in fluid communication with the spike housing (8), a plurality of needles (18) disposed in the communication septum (72, 76), a selection ring insert (30) that rotates and identifies a needle (24) of the plurality of needles (18), and a selection ring (36) exposes the selected needle (24) and moves the selected needle (24) into fluid communication with the septum chamber (80, 82), wherein when the housing (10) is in a first position, the plurality of needles (18) is not exposed, and when the housing (10) is in a second position, one of the plurality of needles (24) is in fluid communication with the
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: July 27, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
  • Patent number: 11052231
    Abstract: Devices and methods for using and manufacturing microstructure arrays having at least a detachable distal area are described.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 6, 2021
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Ashutosh Shastry, Robert Wade Worsham, Parminder Singh
  • Patent number: 11045417
    Abstract: To provide a composition of a coating liquid for microneedle which is optimal for coating a microneedle with a medicinal ingredient. The coating liquid for microneedle of the present invention is an aqueous solution containing, as essential components of a base, a water-soluble polysaccharide, a monosaccharide and/or a disaccharide and a surfactant, characterized in that a ratio of the water-soluble polysaccharide to the base is 2 to 60 mass %, and the hardness after being dried is 10 N or more. The coating liquid for microneedle may further contain a water-soluble polyalcohol, and preferably a monosaccharide and/or a disaccharide is 30 to 95 mass %, a surfactant is 0.05 to 5 mass %, and a water-soluble polyalcohol is 10 mass % or less in the base. As the water-soluble polysaccharide, hydroxypropyl cellulose, hyaluronic acid, or carboxymethyl cellulose is preferable.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: June 29, 2021
    Assignee: COSMED PHARMACEUTICAL CO., LTD.
    Inventors: Ying-shu Quan, Mio Saito, Shouta Kitaoka, Fumio Kamiyama
  • Patent number: 11020540
    Abstract: An attachable needle assembly (2) for use on a medication delivery pen (4), the needle assembly (2) comprising a spike housing (8) that is configured to engage the medication delivery pen (4) and pierce a reservoir septum (6) of the medication delivery pen (4), a needle assembly housing (22) secured to the spike housing (8), the needle assembly housing (22) enclosing a septum (40) with a cavity (42) that is in continuous fluid communication with the spike housing (8), and a plurality of needles (44) configured to pierce the needle assembly septum (40), wherein when the needle assembly housing (22) is in a first position, the plurality of needles (44) are disengaged from the needle assembly septum (40), and when the needle assembly housing (22) is in a second position, one of the plurality of needles (46) enters into fluid communication with the septum cavity (42) and is exposed for medicament delivery.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: June 1, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
  • Patent number: 11007312
    Abstract: An attachable needle assembly (2) used on a medication delivery pen (4), the needle assembly (2) comprising a spike (9) configured to pierce a vial, reservoir or cartridge septum of the pen (4), a needle guide (12) configured to mate with the pen (4), the needle guide (12) enclosing a septum (22) of the needle assembly (2) defining a septum chamber (31), the septum chamber (31) being in fluid communication with the spike (9), a plurality of needles (34) disposed in the septum (22) of the needle assembly (2), a sterility barrier (60) enclosing each of the plurality of needles (34), each of a plurality of sterility barriers (60) having a peel tab (70), each of a plurality of peel tabs (70) being wrapped around the needle guide (12), wherein when one of the plurality of needles (40) is drawn from the needle guide (12) from a first position to a second position, the needle (40) fluidly communicates with the septum chamber (31), and the sterility barrier (60) and the peel tab (70) of the needle (40) are removed.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 18, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon, Daniel Yasevac, Chris Campbell
  • Patent number: 11007282
    Abstract: This invention describes compositions comprising indocyanine green and poly(N-vinylpyrrolidone) and methods of making the same as well as applications thereof for diagnostic and therapeutic uses. One of those applications is the structural and functional assessment of the lymphatic system by fluorescence imaging.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: May 18, 2021
    Assignee: DICRONIS SAGL
    Inventors: Jean-Christophe Leroux, Michael Detmar, Davide Brambilla, Steven Proulx
  • Patent number: 11007358
    Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: May 18, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoki Yamamoto, Seiji Tokumoto
  • Patent number: 11007313
    Abstract: An attachable needle assembly (2) used on a medication delivery pen (4), the needle assembly (2) comprising a communication needle (10) configured to pierce a reservoir septum of the medication delivery pen (4), a spike housing (8) surrounding the communication needle (10) and configured to engage the medication delivery pen (4), a selector ring (16), including a selector opening (18), enclosing a septum (22, 30) of the needle assembly (2) defining a septum chamber (28, 29) that is in fluid communication with the communication needle (10), a plurality of needles (34) disposed in the septum (22, 30) of the needle assembly (2), and a peel tab (60) enclosing each of the plurality of needles (34), wherein the selector opening (18) is aligned with a selected peel tab (60) corresponding to a selected needle (40), the selected peel tab (60) is drawn out of the selector ring (16) and moves the selected needle (40) from a first position to a second position, and the selected needle (40) enters into fluid communication
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: May 18, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
  • Patent number: 10987502
    Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: April 27, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Ryusuke Fudoji, Naoki Yamamoto
  • Patent number: 10980936
    Abstract: An attachable needle assembly (102) for use on a medication delivery pen (104), the needle assembly (102) comprising a housing (1 10) enclosing a hub (106) having a communication needle (108) configured to engage the medication delivery pen (104) and pierce a reservoir septum of the medication delivery pen (104), a communication septum (172, 176) of the needle assembly (102) defining a septum chamber (180, 182) that is in fluid communication with the communication needle (108), a plurality of needles (118) disposed in the communication septum (172, 176), a follower ring (130) that determines which needle (124) of the plurality of needles (118) is to be selected, and a snap ring (136) that exposes the selected needle (124) and moves the selected needle (124) in fluid communication with the septum chamber (180, 182), wherein when the housing (110) is in a first position, the plurality of needles (118) is not exposed, and when the housing (110) is in a second position, the selected needle (124) is in fluid commu
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: April 20, 2021
    Assignee: Becton, Dickinson and Company
    Inventors: Sudarsan Srinivasan, Cole Constantineau, Michel Bruehwiler, Tyson Montidoro, Jeffrey Chagnon
  • Patent number: 10980991
    Abstract: Disclosed is a microneedle for dental material delivery, the microneedle including a needle body portion; an active ingredient coating portion configured to coat the surface of the needle body portion, and including an active ingredient transferred to the skin tissue within a mouth; and a base portion configured to couple with the needle body portion, and to bend along a skin shape within the mouth, wherein the base portion includes at least one of polyethylene (PE), polypropylene (PP), polytetrafluoroethylene (PTFE), polymethylmethacrylate (PMMA), ethylene vinyl acetate (EVA), polycaprolactone (PCL), polyurethane (PU), polyethylene terephthalate (PET), polyethylene glycol (PEG), polyvinyl alcohol (PVA), poly lactide (PLA), poly lactic-co-glycolic acid (PLGA), and polyglycolide (PGA).
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 20, 2021
    Assignee: B&L BIOTECH, INC.
    Inventors: In Whan Lee, Gil Hwan Sung, Seung Ki Baek, In Jeong Choi
  • Patent number: 10967164
    Abstract: Discloses is a method of manufacturing a micro-needle. The method includes a step of preparing a medicinal solution, a step of forming a plurality of tips with the medicinal solution, and a step of forming a cavity in each of the tips. In accordance with such a configuration, a micro-needle in which cavities are formed is provided, whereby it is possible to administer a fixed amount of medicine in a short time.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 6, 2021
    Assignee: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jung Hwan Park, Ji Yeon Kim, Jee Hyun Park, Won Jun Lee
  • Patent number: 10946180
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: March 16, 2021
    Assignee: Corium, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Patent number: 10946181
    Abstract: A plurality of projections in a transdermal administration device each include a columnar portion extending from a first surface of a substrate, and a tapered portion extending from a top of the columnar portion. A maximum angle of an apex of the tapered portion viewed in a direction parallel with the first surface is in a range of 10° or more and 30° or less, a ratio of a length from a proximal end to a distal end of the tapered portion to a length from a proximal end to a distal end of the projection as viewed in a direction perpendicular to the first surface is in a range of 0.45 or more and 0.75 or less, and a pitch (distance between centers of closest projections), viewed in a direction perpendicular to the first surface is in a range of 50 ?m or more and 350 ?m or less.
    Type: Grant
    Filed: August 13, 2018
    Date of Patent: March 16, 2021
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventor: Hiroyuki Kato
  • Patent number: 10893885
    Abstract: A multi-needle assembly for cosmetic procedure includes a main body having an inner space extending from one end to another, a reciprocating member provided in the main body, a needle member placed into the reciprocating member and having a plurality of needles that enter or exit through the one end of the main body, a guide suction into or from which the plurality of needles enter or exit, and length adjusting grooves for moving the reciprocating member in a forward and backward direction.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: January 19, 2021
    Assignee: PANACE CO., LTD.
    Inventor: Sung Tae Yoon
  • Patent number: 10869832
    Abstract: A substance delivery device comprises a substrate, a plurality of dissolvable supporting structures and a plurality of carriers. The substrate attaches to a tissue. The dissolvable supporting structures are disposed on the substrate. The carriers are disposed on the dissolvable supporting structures and encapsulating substances. The present invention further provides a substance delivery method. The substance delivery device and the substance delivery method of present invention is advantageous for providing sustained release effect and rising the applicability of transdermal or transmucosal delivery techniques.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: December 22, 2020
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Mei-Chin Chen, Zih-Yao Lin, Chia-Sui Chen
  • Patent number: 10751484
    Abstract: A needle injection array can comprise a plurality of needles that are fluidly interconnected via a fluid manifold. The fluid manifold can be configured to direct fluid from a syringe to arrive at tips of the needles approximately simultaneously. The fluid manifold also be configured to provide approximately equal dosage or fluid volume through each of the needles to an injection site.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: August 25, 2020
    Assignee: Allergan Industrie, SAS
    Inventor: Bastien Mandaroux
  • Patent number: 10737081
    Abstract: The present invention relates to a painless and patchless shooting microstructure, and a microstructure shooting device. According to the present invention, it is possible to inject a microstructure into the skin within the time of less than one second, and the inconvenience of waiting for the decomposition of a microstructure and removing a patch are completely overcome. A patch-type conventional technology has a problem wherein it is difficult to be applied to a region having hair, but the present invention completely overcomes this problem. According to the present invention, it is possible to precisely control the permeation depth of a microstructure into the skin by controlling discharge power.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: August 11, 2020
    Assignee: JUVIC INC.
    Inventors: Hyung Il Jung, Shayan Fakhraeli Lahiji
  • Patent number: 10716924
    Abstract: Systems, instruments, and methods for minimally invasive procedures including one or more of fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal are described. Embodiments include instrumentation comprising a scalpet assembly coupled to a carrier, and the scalpet assembly includes a scalpet array. The scalpet array includes one or more scalpets configured for fractional resection, fractional lipectomy, fractional skin grafting, fractional scar revision, and/or fractional tattoo removal. The system includes a vacuum component coupled to the scalpet assembly and configured to evacuate tissue from the a site. The carrier is configured to control application of a rotational force and/or a vacuum force to the scalpet assembly.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: July 21, 2020
    Assignee: SRGI HOLDINGS, LLC
    Inventor: Edward Knowlton
  • Patent number: 10688242
    Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: June 23, 2020
    Assignee: AngioDynamics, Inc.
    Inventors: Bradley D. Chartrand, Raymond Lareau, Daniel Buehner, Tobin Kovoor, Brian Nentwick
  • Patent number: 10667830
    Abstract: Device for safely and precisely causing micro-injuries to the dermis to stimulate collagen production a skim remodeling. Specifically, needles on the device pierce the epidermis and basal cell layer into the dermis. The device incorporates safety features for the operator to be able to operate the device with one hand while keeping the other had free during procedures. Additionally, the device incorporates single use safety controls to help prevent cross contamination between patients.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: June 2, 2020
    Assignee: BELLUS MEDICAL, LLC
    Inventors: Joseph Proctor, Tanzeel Ur Rahman, Ronald J Hegler, David J Lapeus, James Mullner
  • Patent number: 10639823
    Abstract: A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus of a microneedle-array manufacturing apparatus is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus can align the relative position of the droplet-delivery apparatus and a mold such that the droplets from the droplet-delivery apparatus are caused to land in each of the recessed parts. The droplet-delivery apparatus delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 5, 2020
    Assignees: NISSHA PRINTING CO., LTD., BIOSERENTACH CO., LTD.
    Inventors: Shinya Yamada, Masateru Chiyama, Kensaku Akita, Takako Ueno, Yuko Ide, Sachi Nagai, Osanobu Akao, Ichiro Ono, Kanji Takada
  • Patent number: 10632065
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 28, 2020
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., ASKA PHARMACEUTICAL CO., LTD.
    Inventors: Shinpei Nishimura, Seiji Tokumoto, Takeshi Ito, Hajime Asada
  • Patent number: 10553502
    Abstract: A system and method for performing a wet etching process is disclosed. The system includes multiple processing stations accessible by a transfer device, including a measuring station to optically measure the thickness of a wafer before and after each etching steps in the process. The system also includes a controller to analyze the thickness measurements in view of a target wafer profile and generate an etch recipe, dynamically and in real time, for each etching step. In addition, the process controller can cause a single wafer wet etching station to etch the wafer according to the generated etching recipes. In addition, the system can, based on the pre and post-etch thickness measurements and target etch profile, generate and/or refine the etch recipes.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: February 4, 2020
    Assignee: VEECO PRECISION SURFACE PROCESSING LLC
    Inventors: Laura Mauer, John Taddei, John Clark, Elena Lawrence, Eric Kurt Zwirnmann, David A. Goldberg, Jonathan Yutkowitz
  • Patent number: 10471245
    Abstract: A method of manufacturing a needle-shaped body includes forming a needle-shaped body precursor such that the needle-shaped body precursor has a base portion and a needle-shaped portion on the base portion, and that the needle-shaped portion has a portion which contacts the base portion and has a form of a polygon, producing a needle-shaped body original plate by forming a curved surface portion in at least a portion of an apex portion of the polygon in a junction portion at a boundary between the base portion and the needle-shaped portion, producing a resin plate by transfer molding with the needle-shaped body original plate such that the resin plate has a concave pattern corresponding to the needle-shaped portion and the curved surface portion, and producing a needle-shaped body by transfer molding with the resin plate such that the needle-shaped body has a transferred needle-shaped portion and a transferred curved surface portion.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: November 12, 2019
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventor: Daizo Uemura
  • Patent number: 10463608
    Abstract: A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: November 5, 2019
    Assignee: THE CORPORATION OF MERCER UNIVERSITY
    Inventor: Martin J. D'Souza
  • Patent number: 10456569
    Abstract: The method of producing a transdermal absorption sheet includes, in this order, a filtration step of carrying out sterile filtration on a base liquid, a base liquid feeding step of feeding the base liquid to a surface of a mold having needle-like recessed portions, tip ends of which are filled with a drug solution, while leaving a space between the drug solution and the base liquid, a drying step of drying the drug solution and the base liquid, and a peeling-off step of peeling off a formed transdermal absorption sheet in which an average concentration of solid contents of the base liquid in the drying step is increased by 5% by weight or more from an average concentration in the base liquid feeding step, and then in a state in which the average concentration is 75% by weight or less, the base liquid is moved into the needle-like recessed portions.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 29, 2019
    Assignee: FUJIFILM Corporation
    Inventor: Satoshi Wakamatsu
  • Patent number: 10441532
    Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions on a mold having the needle-like recessed portions with a polymer solution; drying the filled polymer solution to form a polymer layer; and peeling off the polymer layer, wherein, in drying the polymer solution, low rate drying conditions are set in a concentration range in which an average solid content concentration of the polymer solution is 70 wt % to 80 wt %. When a constant drying rate of water is used as an index, in the concentration range in which the average solid content concentration of the polymer solution is 70 wt % to 80 wt %, and the constant drying rate is lower than a maximum value of a constant drying rate under a drying condition where the average solid content concentration of the polymer solution is less than 70 wt % and more than 80 wt %.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 15, 2019
    Assignee: FUJIFILM Corporation
    Inventor: Satoshi Wakamatsu
  • Patent number: 10384045
    Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic macromolecule and a stabilizing excipient. Described herein are microstructures having a proximal and distal layer, wherein the distal layer which contains the therapeutic molecule does not rely on the presence of a structure-forming polymer to impart the mechanical strength necessary to penetrate the skin. Methods of forming the array, and methods of using the array are contemplated.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: August 20, 2019
    Assignee: Corium, Inc.
    Inventors: Zhongli Ding, Guohua Chen, Parminder Singh
  • Patent number: 10293088
    Abstract: Systems and methods are provided for moving fluids from a patient to a canister and lowering or eliminating the bio-burden of the canister. In one instance, a method for removing fluids from a patient includes using reduced pressure to remove fluids from a patient, delivering the fluids into a reduced-pressure conduit and into a fluid reservoir, exposing the fluids removed from the patient to a UV light source to kill pathogens to create disposable fluids, and disposing of the disposable fluids. Other systems, devices, and methods are presented.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 21, 2019
    Assignee: KCI Licensing, Inc.
    Inventors: Christopher Brian Locke, Timothy Mark Robinson
  • Patent number: 10293149
    Abstract: A multi-site injection system includes a plurality of medicament delivering needles/microprotrusions, a needle/microprotrusion support, a supply of medicament, and a mechanism for providing the medicament to the plurality of needles/microprotrusions in order to effect delivery into a stratum corneum of a user.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 21, 2019
    Assignee: Allergan, Inc.
    Inventors: Steven D. Kimmell, Scott J. Gerondale
  • Patent number: 10285718
    Abstract: A catheter system includes a shaft main body having a rotation axis lumen including a rotation central axis, a revolving lumen that revolves around the rotation axis lumen when the shaft main body is rotated about the rotation central axis, a side-by-side portion in which at least a portion of the rotation axis lumen and at least a portion of revolving lumen exist in side-by-side relationship, and a branch part at which the revolving lumen branches off from the side-by-side portion on a distal side relative to the branch part. The revolving lumen on the distal side relative to the branch part is formed of a distal shaft which has a proximal-side bending portion that bends in such a direction as to become farther away from the rotation axis lumen in radial direction and an opening that communicates with the revolving lumen.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: May 14, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Yuuki Masubuchi
  • Patent number: 10130379
    Abstract: Embodiments of the invention include a multi-lumen catheter for extracting or aspirating a blood clot or thrombus from arterial or veinous sites. Other embodiments are also included herein.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 20, 2018
    Assignee: NorMedix, Inc.
    Inventors: Jeffrey M. Welch, Karl V. Ganske, Gregg Stuart Sutton
  • Patent number: 10098834
    Abstract: The present invention provides methods and kits for preventing, treating or delaying various cardiovascular diseases or disorders especially heart failure by extended release of neuregulin to a mammal. Moreover, the extended release of neuregulin is administered by subcutaneous infusion with a pump.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: October 16, 2018
    Assignee: Zensun (Shanghai) Science & Technology, Co., Ltd.
    Inventor: Mingdong Zhou
  • Patent number: 10085943
    Abstract: Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 2, 2018
    Assignee: INSTITUTE OF NUCLEAR ENERGY RESEARCH, ATOMIC ENERGY COUNCIL, EXECUTIVE YUAN, R.O.C.
    Inventors: Po-Jung Chen, Mao-Chi Weng, Mei-Hui Wang, Chien-Chung Hsia
  • Patent number: 10086183
    Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: October 2, 2018
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shunsuke Arami, Shinpei Nishimura, Seiji Tokumoto, Makoto Ogura
  • Patent number: 10076354
    Abstract: Systems, instruments or devices, and methods or procedures are described in which a scalpet array is applied to a target site with the use of a pattern. The scalpet array comprises scalpets positioned on a device. Skin pixels are incised at the target site via application of a load through the scalpet array. A recipient site is prepared by positioning the pattern at the recipient site and applying the scalpet array to generate skin defects. The incised skin pixels are applied at the skin defects of the recipient site.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: September 18, 2018
    Assignee: SRGI HOLDINGS, LLC
    Inventor: Edward Knowlton
  • Patent number: 9993423
    Abstract: The present invention provides a microneedle array which holds a drug only in the microneedle portions, and a method of manufacturing the same. The microneedle array 2A which holds the drug only on the tips of the microneedles can be manufactured by the microneedle deposition method, i.e. a) the microneedle array 2 is prepared using an water-soluble polymer as a base material; b) a drug solution 1 to be applied to the tips of the microneedle array 2 is prepared; and c) the tips of the microneedle array 2 are contacted with the drug solution 1 for a short time. When the drug solution 1 is a water solution, the biodegradable polymer is of water-soluble, and in addition to the drug, the biodegradable polymer is dissolved in the solution at high concentration, the applied drug is integrated with the microneedle so that only the drug does not fall away during insertion.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: June 12, 2018
    Assignee: COSMED PHARMACEUTICAL CO., LTD.
    Inventors: Ying-shu Quan, Fumio Kamiyama
  • Patent number: 9974935
    Abstract: The present invention relates to a microneedle and a microneedle array. More specifically, it relates to a microneedle and a microneedle array capable of injecting a drug into the surface layer or horny layer of the skin easily, safely and efficiently.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 22, 2018
    Assignee: MEDRX CO., LTD.
    Inventors: Kiyotsuna Toyohara, Taishi Tanaka, Kazuteru Kohno, Takashi Oda, Koichi Masaoka, Katsunori Kobayashi, Masaki Ishibashi, Hidetoshi Hamamoto
  • Patent number: 9968766
    Abstract: To provide a transdermal absorption sheet with which control of a dissolution rate and suppression of drug diffusion can be achieved, and a method of manufacturing the transdermal absorption sheet. A transdermal absorption sheet 100 is provided with a sheet portion 116, a plurality of frustum portions 114 that is disposed on the sheet portion 116, and needle portions 112 that are disposed on the frustum portions 114, each of the plurality of needle portions 112 includes a first layer 120 containing a drug and a second layer 122 not containing a drug, and at least one of the plurality of needle portions 112 contains an air bubble 124.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: May 15, 2018
    Assignee: FUJIFILM Corporation
    Inventors: Satoshi Wakamatsu, Koki Kabata
  • Patent number: 9801920
    Abstract: The present invention relates to an antimicrobial composition derived from a natural substance. Since the composition effectively suppresses Filobasidium, an organism that has been newly identified as causing dandruff, the present invention can effectively prevent and/or treat seborrhoeic dermatitis and dandruff. Also, since the antimicrobial composition of the present invention includes a natural substance as an active ingredient, little consumer aversion will result. Also, it is expected that the antimicrobial composition of the present invention can be used for developing an antidandruff agent having a reduced content of materials which are typically used as antidandruff agents and the safety of which is questionable.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: October 31, 2017
    Assignee: Chung-Ang Univ Industry-Academic Coop. Foundation
    Inventors: Won Yong Kim, Sang Gue Park, Hee Kuk Park
  • Patent number: 9795774
    Abstract: A problem to be solved of the present invention is to provide a drug formulation and a method of administering an active ingredient which allow the active ingredient to be delivered evenly into the site of action in the skin with high efficiency while ensuring stability of the active ingredient over a long time, and which are easily handled and are less stressful for patients. Mean for solving the problem is a microneedle assembly formulation for skin treatment comprising a platform and a plurality of conical or pyramidal microneedles formed on the platform containing a base composed of a bio-soluble and thread-forming polymer substance and an objective substance retained in the base, wherein the objective substance is a substance effective for prevention or treatment of skin senescence, or treatment of skin scar.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: October 24, 2017
    Assignees: BIOSERENTACH CO., LTD., LABO JUVERSA CO., LTD.
    Inventors: Kanji Takada, Ichiro Ono
  • Patent number: 9731104
    Abstract: A dual reservoir access port includes a base having proximal and distal fluid reservoirs. The fluid reservoirs each comprise a bottom and a side wall. A dual prong outlet stem projects from a distal end of the base and comprises a first prong and a second prong. A first fluid channel extends through the first prong to the distal reservoir, and a second fluid channel extends through the second prong to the proximal fluid reservoir. A puncture shield is disposed between at least a portion of the second fluid channel and the bottom of the distal fluid reservoir. A needle-penetrable septum is disposed atop of each of the fluid reservoirs. A cap is placed over and around the port base compressing and sealing the septa against the base. A locking collar may be placed over a dual lumen catheter to lock the catheter to the dual prong outlet stem.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: August 15, 2017
    Assignee: Medical Components, Inc.
    Inventors: Christopher Linden, Raymond Bizup, Cristian M. Ciuciu
  • Patent number: 9717861
    Abstract: A syringe (211) includes a syringe body (217) for receiving and administering a medicament. A needle (215) is received by the syringe body (217). A needle adjusting member (221) is movably disposed on the syringe body (217) between first and second positions. When the needle adjusting member (221) is in the first position, the needle (215) has a first length adapted to draw medicament into the syringe body (217). When the needle adjusting member (221) is in the second position, the needle (215) has a second length for injecting the medicament.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: August 1, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Robert Banik, James Bates
  • Patent number: 9717451
    Abstract: A device includes a plurality of skin penetrating devices for delivering or withdrawing a substance through the skin of a patient. The device has a support formed with a top and bottom end and a plurality of channels extending axially through the support. A plurality of the skin penetrating members is positioned in the channels with a tip extending from the bottom end of the support. A coupling member is attached to the support for coupling with a fluid supply and directing the fluid to the skin penetrating members. The skin penetrating members have a length of about 100 microns to about 2000 microns and are about 30 to 50 gauge.
    Type: Grant
    Filed: April 10, 2012
    Date of Patent: August 1, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: James Down, Noel G. Harvey, Frank E. Martin, Ronald J. Pettis, Alexander G. Lastovich
  • Patent number: 9707339
    Abstract: Devices and methods for obtaining high flow rates in a port catheter system, and devices and methods for using a high flow rate port catheter system are disclosed. In one embodiment, a reservoir is dedicated for aspiration and a separate reservoir is dedicated for infusion. Fluid flow channels associated with aspiration are larger than the fluid flow channels associated with infusion. The catheter connected to the port can have an offset tip configuration. Methods for accessing the port are also disclosed.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: July 18, 2017
    Inventors: Bradley D. Chartrand, Raymond Lareau, Daniel Buehner, Tobin Kovoor, Brian F. Nentwick
  • Patent number: 9687640
    Abstract: An applicator for a microprojection array is described. In one embodiment, the applicator comprises an energy-storing element. Application of force causes the compressed energy-storing element to extend or transition from first and second configurations, releasing stored energy to deploy a holding member in the application which is configured to hold an array of microprojections. In another embodiment, the applicator comprises an energy storing element with two stable configurations, a first stable configuration and second stable configuration. Application of force causes the energy-storing element to transition from the higher energy first stable configuration to the lower energy second stable configuration, releasing the difference in energies of the two states to deploy a holding member in the application which is configured to hold an array of microprojections.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: June 27, 2017
    Assignee: Corium International, Inc.
    Inventors: Joseph C. Trautman, Douglas Joseph Scott Bourne, Anthony Le, Robert Wade Worsham, Parminder Singh
  • Patent number: 9681860
    Abstract: The present invention relates to a halo spray tip atomizer device primarily suited for the application of the fibrin glues. The device offers way to transition seamlessly between a static delivery device and an atomization device. The device is also so configured as to limit possible clogging.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: June 20, 2017
    Inventor: Dennis L Steffen
  • Patent number: 9649281
    Abstract: A transdermal absorption sheet and a manufacturing method for the transdermal absorption sheet includes a laminating step of forming a multilayer film with a viscosity difference by forming, on a support, a lower layer containing a first transdermal absorption material and an upper layer containing a drug and a second transdermal absorption material and having a lower viscosity than the lower layer, a filling step of filling needle-like recessed portions corresponding to inverted needle-like protruding portions with a solution of the transdermal absorption material by pressing a mold in which the needle-like recessed portions are arranged in a two-dimensional array, against a surface of the multilayer film supported by the support to allow the multilayer film to flow, a solidifying step of solidifying the multilayer film with the mold pressed against the surface of the multilayer film, and a peeling-off step of peeling the solidified multilayer film from the mold.
    Type: Grant
    Filed: May 12, 2015
    Date of Patent: May 16, 2017
    Assignee: FUJIFILM Corporation
    Inventors: Junya Yoshida, Seiji Kasahara, Takayoshi Oyamada, Yanlong Che
  • Patent number: 9636490
    Abstract: A microneedle and a microneedle array, which have both aspects of safety and easiness to use and can administer a predetermined dose of a medical agent without causing a pain by smoothly running into the skin surface layer of a patient, includes a frustum and a forward end portion thereon, the forward end portion having a forward end apex angle in the range of 15 to 60° and a forward end diameter in the range of 1 to 20 ?m and satisfying the expression H/D?5, where H is a total height of the microneedle, and D is a diameter of a bottom surface of the frustum).
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: May 2, 2017
    Assignee: MEDRX CO., LTD.
    Inventors: Koichi Masaoka, Keizo Ikari, Takashi Oda, Katsunori Kobayashi, Hidetoshi Hamamoto, Masaki Ishibashi, Kiyotsuna Toyohara