Abstract: A defibrillation assembly energizable through pad removal is provided. The defibrillation assembly includes an electromechanical component; an energy storage element that supplies power to the electromechanical component; circuitry configured to generate a defibrillation waveform, wherein the circuitry is isolated from the energy storage element by the electromechanical component; and electrode pads through which the defibrillation waveform is delivered to a patient, wherein a removal of at least one of the electrode pads from an initial position to a further position causes the power to flow to the circuitry through the electro-mechanical component.

Abstract: A container, a toothbrush, or a device including at least one sacrificial electrode. In one aspect, the container may include a body adapted to contain an oral care solution and a cap selectively removable from the body. The cap may include a cavity configured to contain a fluid, a first electrode comprising a sacrificial metal, a second electrode spaced from the first electrode, and an electrical connection electrically connecting the first electrode and the second electrode to a power source. Activation of the power source may generate an electric field between the first and second electrodes, thereby causing the sacrificial metal of the first electrode to release ions into the fluid in the cavity of the cap.

Abstract: The present invention provides a method of inhibiting the growth of proliferating cells or viruses in living tissue, the method comprising: applying mid-level frequency AC current electromagnetic signals to the living tissue with a transducer comprising a magnetically conductive material passing through a conduction ring energized by an electrical signal to create the mid-level frequency AC current electromagnetic signals within the living tissue; wherein the mid-level frequency AC current electromagnetic signals have a frequency in the range of about 50 kHz to about 300 kHz and are produced with an AC voltage generator; and circulating fluid in the living tissue provide a secondary coil for the transmission of the mid-level frequency AC current electromagnetic signals.

Abstract: A medical device comprising a multilayer printed circuit board (PCB) comprising a heating element on an inner layer of the PCB; a single cell electrical power source to power the heating element; and a chamber adapted to contain a liquid, at least part of said chamber being defined by a thermally conductive material configured to provide a thermal transfer interface between the chamber and the PCB.

Abstract: A method for treating a medical condition in a patient in need thereof is provided. The method includes applying light to the patient thereby stimulating the immune system of the patient, wherein the applying includes irradiating substantially the entire body of the patient with high intensity blue light having a wavelength, intensity, and duration configured to provide immune system stimulation sufficient to treat the medical condition, the stimulation including increasing the population of T-cells in the patient's bloodstream to treat the medical condition. Also included is a method for activating T cells in a subject in need thereof.

Abstract: Dermatological systems and methods for providing a therapeutic laser treatment of tissue having poor chromophore selectivity using a laser source having a grating element to provide laser light having reduced linewidth. In some embodiments, the linewidth is reduced by at least half compared to the linewidth that would be provided in a system without the grating filter element. The linewidth may be reduced in some cases to 500 GHz or less, 300 GHz or less, or 200 Hz or less.

Abstract: A mask instrument includes a flexible mask and a controller. The flexible mask includes a first flexible layer, a second flexible layer, a plurality of functional layers located between the first flexible layer and the second flexible layer, and a plurality of electrodes electrically connected with the plurality of functional layers. The flexible mask is electrically coupled with the controller via the plurality of electrodes. The second flexible layer comprises at least one hole at a position corresponding to the plurality functional layers, and at least one portion of the plurality of functional layer is exposed out of the second flexible layer from the at least one hole. A method for using the mask instrument is further provided.

Abstract: A fluid interface device for delivering fluid to and/or withdrawing fluid from a patient, the device comprises a peripheral base element (2) and a fluid transmission element (4) sealingly connected to the base element and forming a central portion of the device. The fluid transmission element comprises a front platelet (6) with a primary face (8) and a secondary face (10) opposed thereto, the primary face being in contact with a patient's body fluid region (12) when the device is implanted in the patient, the fluid transmission element further comprising a counterplate (14) sealingly stacked against the secondary face of the front platelet and forming a buffer volume (16) therebetween. The front platelet comprises at least one array of microchannels (18) defining a fluid passage between the buffer volume and the primary face, the microchannels having an opening of 0.2 to 10 ?m. The counterplate has at least one fluid port (20; 20a, 20b) for fluid delivery to and/or fluid withdrawal from the buffer volume.

Abstract: An apparatus for use with an access port implanted in a living body includes an adhesive flange and a base coupler on the adhesive flange, the base coupler including an opening and an attachment configuration to attach and detach with a plurality of components including a locator assembly for locating the access port.

Abstract: A carrier device and methods of use are described. The device and methods are directed toward implanting in biological tissue and for releasing a medical payload or functional material in biological tissue according to a remote magnetic trigger. The carrier device has a cavity with an opening through an external surface of the device. The carrier device includes at least one moveable, magnetic element sensitive to a magnetic field gradient. When a magnetic field gradient, rotating magnetic field, or uniform magnetic field, or a combination of thereof is applied to the tissue, the moveable magnetic element provides release of the medical payload or functional material through the cavity opening. In some embodiments, payload release can be started, stopped, and restarted at a later time or place. In addition to payload release, devices of this invention are equipped with a propelling element, the propelling element is responsive to external stimuli that enables propulsion and navigation of the device.

Abstract: The invention is directed to a light source device comprising a light emitting element for emitting a blue light having a wavelength ranging from 435 to 500 nm, the light source device being configured to provide the blue light to at least one cell at a transmitted fluence ranging from 0.01 to 18. J/cm2 to promote or induce growth and proliferation of the cell and wherein the light emitting element has a power density ranging from 0.05 to 30 mW/cm2. The invention is also directed to a light source assembly comprising a product adapted to be in contact with the skin or a wound and a light source device connected to the product for providing blue light to at least one skin cell, preferably of the wound.

Abstract: An electronic device includes: a processing unit; and a plurality of interfaces configured to transmit commands to the processing unit. The processing unit invalidates the commands from the interfaces other than the interface from which the command first received by the processing unit after start-up is transmitted. The processing unit has a plurality of modes, and invalidates the commands other than the command that is valid for the selected mode. The plurality of interfaces include a user interface configured to detect an operation of a user and a communication interface configured to communicate with an external device.

Abstract: Provided is an electrotherapy device suitably used in electroporation method, and specifically configured to inject medicine and the like into deep inside of the body. The electrotherapy device has an outer shaft having a lumen and extending in a distal-proximal direction; an inner shaft disposed in the lumen of the outer shaft; a needle tube fixed to the inner shaft; and at least one linear conductor having at least one electrode needle fixed to the inner shaft and having at least one conductive line connected to a proximal part of the electrode needle, the needle tube and the electrode needle configured to project or retract from a distal part of the outer shaft.

Abstract: According to an embodiment of the present disclosure, a light outputting device for skin care includes a care module including at least one or more care light sources and a care module substrate on which the at least one or more care light sources are mounted; a housing configured to surround the care module; a care body including the care module and the housing; and a length adjustment part connected to both ends of the care body, wherein the housing and the care module substrate are formed to have a first curvature in a first direction and a second curvature in a second direction, and wherein at least one of the first curvature and the second curvature is variable within a predetermined range.

Abstract: A completely de-energizable defibrillator is provided, allowing the electrical components of the defibrillator to be electrically unbiased while the defibrillator is not in use. The de-energizing of the defibrillator can be accomplished by separating the battery from the rest of the defibrillator circuitry with an electromechanical component, such as a power switch like a magnetically-triggered reed switch or a mechanically-triggered switch. The de-energizing of the defibrillator can also be accomplished by including in the defibrillator a removable piece of insulating material between the battery and the circuitry. The de-energizing of the defibrillator can also be accomplished by a change in configuration or position of the moveable components of the AED. The preparation of the defibrillator for use triggers the circuitry to become energized.

Abstract: A dry mouth hydrating device includes a generally U-shaped tray having a base and two parallel arms extending from the base; a cavity defined within the tray providing a reservoir for the placement of a liquid; a first aperture defined in the base of the tray, in communication with the cavity; and tubing provided between the first aperture and the cavity for allowing the liquid to flow out of the cavity at a desired rate. The tray is adapted to surround the upper teeth of the wearer and to be retained within the oral cavity along the dental arch between the lips and gums. Once positioned on the upper teeth of the wearer, liquid can drip from the cavity over the tongue of a user wearing the device for treating or preventing xerostomia. A second, resealable aperture may be defined in communication with the cavity to allow the cavity to be refilled.

Abstract: A laser needle treatment system according to the present invention comprises: an optical cable connected to a laser generator and providing a laser generated by the laser generator; a hand piece in which a plurality of lenses for amplifying or extending the laser provided from the optical cable are installed; and a needle unit connected to the bottom of the hand piece to receive a laser through the hand piece and pass through the skin surface so as to directly emit the laser intradermally to an operation area, wherein the hand piece comprises: a focus lens to which the laser provided from the optical cable is incident; a convex lens for extending or amplifying a laser emitted from the focus lens; a collimator lens for emitting the laser emitted from the convex lens to be parallel to a proceeding direction; and an optical lens part connected to the needle unit and including a plurality of optical lenses Installed therein to extend or amplify a laser emitted from the collimator lens and transmit the same to the

Abstract: A method for removing bodily fluid includes drawing bodily fluid that has accumulated in excess, converting the drawn fluid from bulk liquid form to aerosol form, and disposing of the aerosol via evaporation of liquid droplets and absorption and/or diffusion of vapor. Conversion from bulk liquid to aerosol may include collecting the bulk liquid fluid in a reservoir, conveying the bulk liquid bodily fluid to an atomizer, converting the bulk liquid fluid into an aerosol having ultrafine droplets, and ejecting the aerosol into a subcutaneous space for disposal via evaporation of liquid droplets and absorption and/or diffusion of vapors. The method may be performed with a subcutaneous atomizer that may be controlled locally or by an external transmitter for effecting a conversion and mist rate to keep pace with the accumulation of excess bodily fluid.

Abstract: Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided.

Abstract: Presented herein are dissolution barriers for use with tissue-stimulating prostheses. As described further below, a tissue-stimulating prosthesis comprises a stimulating assembly including an elongate insulating carrier member and a plurality of electrode contacts disposed along the carrier member. A continuous dissolution barrier is disposed on the surface of the stimulating assembly so as to substantially encapsulate/enclose the plurality of electrode contacts and the carrier member. The continuous dissolution barrier is configured to inhibit in situ dissolution of the plurality of electrode contacts.

Abstract: The disclosure relates generally to methods for treating or slowing progression of a tumor, a neurodegenerative disease or a cognitive impairment, and for improving cognition, comprising administration of light therapy. The disclosure also relates to methods for activating oral stem cells, comprising administration of light therapy. Further provided herein are methods for improving cognition, comprising administering to the oral cavity of a subject in need thereof an effective amount of light. Additionally provided herein are methods for treating autism or Asperger's syndrome, comprising administering to the oral cavity of a subject in need thereof an effective amount of light.

Abstract: Described herein are devices, systems and methods for delivering therapeutic compositions to plants. Specifically exemplified herein is a device comprising a plurality of microneedles for creating pores in an effective area of a target plant and then applying a second device loaded with the therapeutic composition. The microneedle device is designed to impart pores that allow for access of the therapeutic composition to the plant vascular system including phloem.

Abstract: The present invention relates to a treatment apparatus and a method of controlling the same. There are provided a treatment apparatus, including a handpiece, an RF generator generating RF energy, an insertion unit configured to advance and retract toward one direction of the handpiece, selectively inserted into a tissue, and electrically connected to the RF generator to transfer the RF energy to the inside of the tissue, and a substance storage unit receiving a therapeutic substance therein and detachably installed on one side of the handpiece to transfer the substance to the inside of the tissue by the advancing operation of the insertion unit and a method of controlling the same.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to gel-phase inks suitable for extrusion-based 3D printing and methods of making the same, as well as anisotropic hydrogels printed from the same. In another aspect, the disclosure relates to linear contractile elements constructed from the anisotropic hydrogels and 3D structures with programmed morphologies and motions comprising the linear contractile elements. In still another aspect, the disclosure relates to a process for preparing soft materials and a method to create 3D structures starting from the gel-phase inks disclosed herein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: An ultrasonic electromechanical system for an ultrasonic surgical instrument may include an ultrasonic blade, a clamp arm disposed opposite the ultrasonic blade, an ultrasonic transducer configured to oscillate the ultrasonic blade in response to a drive signal, and a control circuit coupled to the ultrasonic transducer. The control circuit can be configured to determine a temperature of the ultrasonic blade, increase an amount of power of the drive signal when the temperature of the ultrasonic blade is less than a first predetermined value, and decrease the amount of power of the drive signal when the temperature of the ultrasonic blade is greater than a second predetermined value. The second predetermined value may be greater than the first predetermined value. An ultrasonic generator connectable to the ultrasonic electromechanical system may include the control circuit.

Abstract: A disclosed antimicrobial medical device includes a fluid transfer device configured to couple between a patient and a fluid reservoir, a fluid pathway extending through the fluid transfer device, a first electrode coupled to the fluid transfer device, and a second electrode coupled to the fluid transfer device and spaced apart from the first electrode. The first electrode includes a first conductive material and the second electrode includes a second conductive material different from the first conductive material. The second electrode is configured to form a galvanic cell with the first electrode.

Abstract: A device for electroporating cells of a mammalian mucosal membrane includes a housing, an electrode microneedle plate, a voltage return electrode coupled to the housing, and an energy source. The energy source is configured to generate and deliver through the electrode microneedle plate and the voltage return electrode at least one pulse of electrical energy having an electric potential sufficient to electroporate the cells. The electrode microneedle plate is configured to provide an even distribution of a pharmaceutical formulation from the housing and to the mucosal membrane. The electrode microneedle plate includes a plurality of microneedles that are configured to contact the mucosal membrane, deliver the pharmaceutical formulation to a specific depth, and deliver the at least one pulse of ergy to the cells.

Abstract: PROTECTED NEEDLE WITH HIGH ULTRASOUND VISIBILITY FOR PERFORMING ULTRASOUND-GUIDED PERCUTANEOUS ELECTROLYSIS OR NEUROMODULATION TECHNIQUES, consisting of a dry puncture or acupuncture needle formed by a conductive metallic grip (2), coupled to the handle that connects it to the device that generates the electric current to be applied, and a body (3), also conductive and metallic, in the form of a cylindrical, thin and long rod, of variable length among 30, 40, 50, 60, 75 and 100 mm, with the blunt tip (4), where the body (3), and preferably also the grip (2), are both made of galvanized steel with high ultrasound visibility and in that, in addition, said body (3) is provided with a biocompatible electrically insulating protection layer (5) such as a Teflon coating, which covers practically its entire length, except for a working segment (6) of variable length (I) before the blunt tip (4).

Abstract: A garment is manufactured by printing an ink including at least five percent of a ceramic by weight onto a first side of a fabric portion to provide a fabric with a ceramic print, the ceramic print covering at least ten percent and less than ninety percent of the inside of the fabric portion, and incorporating the fabric with the ceramic print into a garment with the first side of the fabric portion on an inside of the garment such that the ceramic print is exposed on the inside of the garment. In addition, a garment includes a fabric panel having an inner, user-facing side and an outer side opposite the inner side, and a discontinuous printed layer disposed on the inner side of the fabric panel, the printed layer including a heat retaining material and a binder, where the heat retaining material is present in an amount effective to provide heat retention properties to the fabric panel.

Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.

Abstract: Antimicrobial dressings for prevention and mitigation of biofilm and bacterial infection by an applied electric current are provided. Methods of making the dressings and methods of applying an electric current to promote the wound healing process are also disclosed.

Abstract: An inhaler includes an atomizing unit including a piezoelectric element substrate having a first IDT including a pair of interlocking comb-shaped electrodes. The atomizing unit is configured to atomize liquid by a surface acoustic wave generated by applying a high-frequency voltage to the pair of interlocking comb-shaped electrodes, and a controller is configured to monitor a resonant frequency of the pair of interlocking comb-shaped electrodes and apply a voltage to the pair of interlocking comb-shaped electrodes at a frequency determined based on the monitored resonant frequency.

Abstract: A high-density microneedle of the present disclosure includes: a sheet portion attached to skin; a substrate portion arranged on the sheet portion; and a plurality of insertion pieces arranged on the substrate portion, wherein the substrate portion is arranged on the sheet portion while having a plurality of layers formed therein.

Abstract: The invention refers to an antimicrobial, exfoliating and seboregulating hydrosoluble composition comprising a combination of diallyl disulphide modified oxide (DDMO) and alpha hydroxyethanoic acid (glycolic acid), which acts removing bacteria affecting the skin including those caused by acne, said composition also provides deep cleansing, exfoliating action, reduces epidermal cohesion facilitating cellular change, preventing the occurrence of several forms of acne in the skin and additionally producing seboregulating effects by avoiding blockage of sebaceous glands.

Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. Included is a method of treating tissue with electrical energy, the method comprising: delivering electrical energy to tissue using one or more electroporation devices comprising one or more electrodes; and cooling the tissue, surrounding tissue, one or more of the electrodes, or one or more of the electroporation devices to minimize heating. In embodiments, the invention can be used to treat solid tumors, such as brain tumors, and in some embodiments, exemplary methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors.

Abstract: A light-based dental treatment system includes a handle generator having a generator housing and at least one light element configured to generate therapeutic light. The handle generator includes an alignment collet having a light passage extending along a movable interior collet profile. At least one delivery shaft assembly is selectively coupled with the handle generator. The at least one delivery shaft assembly includes a delivery shaft having proximal and distal shaft profile and a proximal light port. A distal light port of the delivery shaft is configured to deliver therapeutic light from the delivery shaft to a treatment location. The interior collet profile of the alignment collet is configured to grasp the delivery shaft and align the proximal light port with the at least one light element.

Abstract: A method for providing electrical current treatment by an apparatus having a first electrode, a second electrode, and a processor is provided. The method includes delivering an electric current through an object in contact with the first electrode and the second electrode; controlling, by the processor, the electric current delivered by the first electrode and the second electrode to have a specific waveform; and providing a notification at a predetermined time to notify a user to move the apparatus.

Abstract: A blood processing apparatus including a blood supply unit, a centrifuge, a light irradiation unit, a filtering device, and a blood collection unit, which is characterized in that blood is introduced into the centrifuge and centrifuged, the centrifuged blood is passed through a transparent tube provided in the light irradiation unit while being irradiated with light applied, from the outside of the transparent tube, by a light irradiation device configured to include an infrared lamp with a wavelength of 830±5 nm, a red light-emitting diode (LED) lamp with a wavelength of 635±6 nm, a blue LED lamp with a wavelength of 420±5 nm, a green LED lamp with a wavelength of 530±5 nm, a yellow LED lamp with a wavelength of 585±5 nm, and ultraviolet (UV) lamps, and the blood irradiated with the light is filtered using the filtering device and collected in the blood collection unit.

Abstract: There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.

Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body at higher field strengths by switching off one or more electrode elements that are overheating without switching off other electrode elements that are not overheating. This may be accomplished using a plurality of temperature sensors, with each of the temperature sensors positioned to sense the temperature at a respective electrode element; and a plurality of electrically controlled switches, each of which is wired to switch the current to an individual electrode element on or off. A controller input signals from the temperature sensors to determine the temperature at each of the electrode elements, and controls the state of the control input of each of the electrically controlled switches to selectively switch off the current or adjusted the duty cycle at any electrode element that is overheating.

Abstract: A method and apparatus using high voltage and low amperage to control and reduce pain by applying an electrical stimulus to a patient. A generator module selectively generates a desired electrical stimulus to the patient via leads in electrical connection with the outputs of the generator module and connected to respective electrodes for attaching to at least one anatomical feature of a body of the patient, to administer the electrical stimulus. Duration, voltage and current circuits are included in the generator module for selectively establishing duration, voltage and current of the electrical stimulus. Respective duration, voltage and current slide switches manually adjust the respective duration, voltage and current circuits between a low level and a high level. A scale indicates the levels of duration, voltage and current such that low levels are indicated at a bottom of the scale and high levels are indicated at a top of the scale.

Abstract: A device for killing blood-borne pathogens, and a method of using the device to effectively remove the blood-borne pathogens from a body of a human or an animal is claimed. The device comprises a wire that is inserted into a bloodstream of a patient, which releases metallic ions which effectively kill the pathogens. There are several embodiments, each of which has a combination of covered and uncovered portions of the wire. The wire is electrically connected to both a source of power and a power supply with a printed circuit board or a controller/software, which controls an intensity and a duration of a treatment.

Abstract: A combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller. Each of the modules includes: a power line; a ground line; a multiplexer having a plurality of identified input channels, at least a subset of the input channels being selectively connected to one of the power and ground lines; a first digital logic line configured to select the input channels; a voltage reference line having a first resistor in line with an output of the multiplexer; a branch line connected to the voltage reference line having a normally closed switch thereon to connect the branch line to the ground line, the switch being opened with connection to a further module. The master controller selects, in sequence, the same identified input channels across all of the modules with measuring a reference voltage thereacross.

Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode.

Abstract: Embodiments of the invention relate to a resin composition, in particular suitable for printing, a kit comprising components of the resin composition, printing methods, a polymer obtained by the printing methods, an article comprising or formed from the polymer, uses thereof, and a composition. The resin composition comprises at least one compound C1 having at least one terminal alkyne functional group; at least one compound C2 having at least two thiol functional groups; at least one compound C3 having at least one carbon-carbon double bond; at least one photoinitiator; and at least one stabilizer.

Abstract: Disclosed soluble PD-1 (sPD-1) proteins and nucleic acids, and therapeutic compositions comprising sPD-1 proteins and nucleic acids, for enhancing immunity of a subject against coronavirus infection. Disclosed are soluble PD-1 fusion proteins that include a soluble PD-1 protein fragment and an antigenic protein fragment, preferably where the antigenic protein fragment comprises a coronavirus protein fragment. In some forms, the coronavirus protein fragment is derived from a coronavirus receptor binding domain (RBD) or a coronavirus nucleoprotein (N). In some forms, the sPD-1 proteins, nucleic acids, and compositions are formulated as a vaccine composition. Also disclosed are methods for treating a subject at risk of or suffering a coronavirus infection.

Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.

Abstract: A method and apparatus are disclosed for providing forward fluid delivery through an electrosurgical device, while avoiding coring when energy is delivered to the electrosurgical device. The device has a distal face defining an opening, with the distal face including at least one cutting portion and at least one non-cutting portion. An embodiment of the electrosurgical device for puncturing tissue includes an elongate member defining a lumen for fluid; a distal portion including an electrode and the distal face which defines at least one aperture. The portion of the at least one cutting portion defines a leading portion partially surrounding a circumference of the at least one aperture wherein the outer diameter of the at least one of the distal portion of the electrosurgical device or the electrode decreases towards a distal tip of the electrosurgical device.

Abstract: Provided is a microneedle patch which is easily to be applied on a skin surface. One or more holes are provided inside a protective sheet of the microneedle patch, and one or more cutting lines running from an outer edge of the protective sheet toward the holes are also provided. The cutting lines may be symmetrically arranged on both sides of the hole. Providing an incision on the outer edge of the cutting lines of the protective release sheet facilitates cutting along the cutting lines. In the use of the microneedle patch, both sides of the cutting line of the protective release sheet are held and torn so as to bring out a microneedle array adhesive sheet and apply it on a skin. Then the microneedle array surface is slightly compressed, thereby the microneedle is inserted into the stratum corneum.

Abstract: In one aspect, the disclosure relates to drug delivery devices for the ionophoretic delivery of a therapeutic agent(s) to the eye. In some aspects, the disclosed ionophoretic ocular delivery device is configured for delivery of a therapeutic agent to the anterior portion of the eye. In various aspects, the present disclosure provides methods for treatment of an ophthalmological disorder, disease, or clinical condition by delivering a therapeutic agent(s) to the eye using a disclosed ionophoretic ocular delivery device. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.