Infrared, Visible Light, Ultraviolet, X-ray Or Electrical Energy Applied To Body (e.g., Iontophoresis, Etc.) Patents (Class 604/20)
  • Patent number: 10780267
    Abstract: The present invention relates to apparatus for topical application of material for cosmetic purposes (10). The apparatus for topical application of material (10) comprises measurement apparatus configured to measure a property of skin of a human or animal subject and actuating apparatus configured to change a permeability of the skin of the human or animal subject in dependence on the measured property of the skin. The apparatus for topical application of material (10) further comprises application apparatus configured to apply material for cosmetic purposes to the skin whilst substantially no iontophoretic current flows through the skin and after the permeability of the skin has been changed.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: September 22, 2020
    Assignee: UNIVERSITY OF STRATHCLYDE
    Inventors: David Heath, Barry Hochfield
  • Patent number: 10780266
    Abstract: Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: September 22, 2020
    Assignee: InCube Labs, LLC
    Inventors: Mir Imran, Mir Hashim, Glen McLaughlin, Huma Arastu, Rekha Vaidyanathan, Joel Harris, Radhika Korupolu, Andrew Mangogna, Chang Ong, Sanjay Patel, Lu Wang, Timothy Williams
  • Patent number: 10773098
    Abstract: The invention provides a therapy method for glioblastoma multiforme (GBM). The therapy method uses a low-dose radiation to realize GBM tumor cell-targeted radiotherapy via sequentially administration of radiation enhancer-incorporated nanocarriers, 5-aminolevulinic acid, therapeutic ultrasound and therapeutic radiation.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: September 15, 2020
    Assignee: National Yang-Ming University
    Inventors: Tse-Ying Liu, Ming-Hong Chen
  • Patent number: 10765857
    Abstract: A cutaneous electrode device intended for being connected to an electrical pulse generator including a planar body and an electrically insulating material on which at least one electrode, at least one means for connecting to the electrical pulse generator and at least one conductive element electrically connecting said electrode to said connection means are formed. The at least one electrode ends at an inner surface of the body and the at least one connection means ends at an outer surface of the body. The body also has at least one projecting portion that is mechanically connecting an electrode and a connection.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: September 8, 2020
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Nicolas Karst, Simon Perraud
  • Patent number: 10765632
    Abstract: The present invention relates to a pharmaceutical composition comprising the combination of (i) at least one biocompatible nanoparticle and (ii) at least one carrier comprising at least one pharmaceutical compound, to be administered to a subject in need of such a pharmaceutical compound, wherein the combination of the at least one biocompatible nanoparticle and of the at least one carrier comprising the pharmaceutical compound(s) potentiates the compound(s) of interest effectiveness in therapy, prophylaxis or diagnosis. The invention also relates to such a composition for use for administering the pharmaceutical compound(s) in a subject in need thereof, wherein the at least one biocompatible nanoparticle and the at least one carrier comprising the at least one pharmaceutical compound are to be administered separately in a subject in need of said pharmaceutical compound, typically between more than 5 minutes and about 72 hours one from each other.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: September 8, 2020
    Assignee: CURADIGM SAS
    Inventors: Matthieu Germain, Marie-Edith Meyre, Agnes Pottier, Laurent Levy
  • Patent number: 10765768
    Abstract: An ultraviolet irradiation system includes a medical device having a central lumen, an optical fiber having a longitudinal length, and an ultraviolet wave generator, wherein ultraviolet waves generated by the wave generator are dispersed along the longitudinal length of the optical fiber to disinfect the central lumen of the medical device.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: September 8, 2020
    Assignee: TELEFLEX MEDICAL INCORPORATED
    Inventors: John C. Victor, David Troy Rowe
  • Patent number: 10758722
    Abstract: Apparatus is provided that includes a parenchymal electrode, configured to be implanted in brain parenchyma of a subject identified as at risk of or suffering from a synucleinopathy; and a cerebrospinal fluid (CSF) electrode, configured to be implanted in a CSF-filled space of a brain of the subject, the CSF-filled space selected from the group consisting of: a ventricular system and a subarachnoid space. Control circuitry is configured to drive the parenchymal and the CSF electrodes to clear alpha-synuclein (aSyn) from the brain parenchyma into the CSF-filled space of the brain. Other embodiments are also described.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: September 1, 2020
    Assignee: RAINBOW MEDICAL LTD.
    Inventors: Yossi Gross, Alex Tendler, Gideon Fostick
  • Patent number: 10758118
    Abstract: In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: September 1, 2020
    Assignee: IRIDEX Corporation
    Inventors: Howard Chen, David Buzawa
  • Patent number: 10756621
    Abstract: A voltage regulator provides an output voltage and an output current. The output voltage decreases with an increase of the output current when the output current is lower than a current breaking point, and the output voltage is maintained when the output current reaches the current breaking point.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: August 25, 2020
    Assignee: Chengdu Monolithic Power Systems Co., Ltd.
    Inventors: Binci Xu, Yongliang Wang, Tao Zhao, Lijie Jiang
  • Patent number: 10753974
    Abstract: The present disclosure relates to articles (and the manufacture thereof) that use electrical energy to heat a material to form an inhalable substance, the articles being sufficiently compact to be considered “hand-held” devices. In certain embodiments, the articles can particularly be characterized as smoking articles. The smoking article can be adapted to detect the status of a cartridge portion of the smoking article. The smoking article includes a control body portion having a control body engagement end, wherein the control body portion houses a control component and a power source therein. The article further includes a cartridge body portion that has a cartridge body engagement end configured to removably engage the control body engagement end of the control body portion. The cartridge body portion houses a consumable arrangement and a heating connection operably engaged therewith comprising at least one heating element and a fusible link.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: August 25, 2020
    Assignee: RAI Strategic Holdings, Inc.
    Inventors: Charles Jacob Novak, III, Frederic Philippe Ampolini, Allen Michael East, Raymond C. Henry, William Robert Collett
  • Patent number: 10729533
    Abstract: An apparatus is configured to be implanted within a biological structure. The apparatus includes a plurality of magnetic elements, an absorbable component, and a non-absorbable component. The plurality of magnetic elements are configured to transition the biological structure between an occluded state and an opened state. The plurality of magnetic elements are biased to encourage the biological structure toward the occluded state. The absorbable component includes a therapeutic substance. The absorbable component is configured to temporarily couple the plurality of magnetic elements with the biological structure when the apparatus is initially implanted within the biological structure.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: August 4, 2020
    Assignee: Ethicon LLC
    Inventors: Frederick E. Shelton, IV, Timothy S. Bedard
  • Patent number: 10722160
    Abstract: A non-invasive epidermal electrochemical sensor device includes an adhesive membrane; a flexible or stretchable substrate disposed over the adhesive membrane; and an anodic electrode assembly disposed over the flexible or stretchable substrate including an iontophoretic electrode. The device includes a cathodic electrode assembly disposed adjacent to the anodic electrode assembly over the flexible or stretchable substrate and includes an iontophoretic electrode. Either the cathodic electrode assembly or the anodic electrode assembly also includes a sensing electrode that includes a working electrode and at least one of a counter electrode or a reference electrode. The iontophoretic electrode in either the anodic electrode assembly or the cathodic electrode assembly that includes the sensing electrode is disposed on the substrate to at least partially encompass the working electrode and the at least one of the counter electrode or the reference electrode.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: July 28, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Joseph Wang, Amay Jairaj Bandodkar, Patrick Mercier
  • Patent number: 10716503
    Abstract: Systems, methods, sensors, and software for providing enhanced measurement and detection of patient pain response are provided herein. In a first example, a measurement system is provided that includes a capacitive system configured to measure a capacitance signal of tissue of the patient using a capacitive sensor applied to the tissue of the patient. The measurement system also includes a patient monitor configured to measure an electrical signal representing brain activity of the patient using a brain activity sensor applied to the tissue of the patient. The measurement system also includes a processing system configured to determine pain metrics based at least on the capacitance signal and the electrical signal, and determine a pain response of the patient based at least on the pain metrics and pain calibration information for the patient.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: July 21, 2020
    Assignee: Covidien LP
    Inventors: Paul S. Addison, James N. Watson, Eric Morland
  • Patent number: 10709491
    Abstract: Systems, methods and computer-accessible mediums can be provided that can establish particular parameters for electric pulses based on a characteristic(s) of the tissue(s), and control an application of the electric pulses to tissue(s) for a plurality of automatically controlled and separated time periods to ablate the tissue(s) through mediation of membrane potential and through inducing the cells through a plurality of charge-discharge cycles such that an electroporation of a majority of the tissue(s) is prevented or reduced.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: July 14, 2020
    Assignee: MEMORIAL SLOAN-KETTERING CANCER CENTER
    Inventors: Govindarajan Srimathveeravalli, Stephen Barnett Solomon
  • Patent number: 10695562
    Abstract: A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: June 30, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Joseph DeSimone, Mary Napier, Jonathan Pillai, James Byrne, Lukas Miller Roush, Jen Jen Yeh, Matt Parrott
  • Patent number: 10695442
    Abstract: A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged PEG, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol. The nanoparticles are coated with polyethylene glycol at a density that imparts a near neutral charge and optimizes rapid diffusion through the brain parenchyma. Methods of treating a disease or disorder of the brain including administering a therapeutically effective amount of nanoparticles densely coated with polyethylene glycol are also provided.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: June 30, 2020
    Assignee: The Johns Hopkins University
    Inventors: Justin Hanes, Jung Soo Suk, Panagiotis Mastorakos, Graeme Woodworth, Clark Zhang
  • Patent number: 10695561
    Abstract: Embodiments of the invention provide patch assemblies for iontophoretic transdermal delivery of therapeutic agents. An embodiment provides a patch assembly comprising a conformable patch for delivery of the agent and having a tissue contacting side including an adhesive. The housing has a bottom surface for engaging a non-tissue contacting side of the patch, a current source such as a battery and a controller for controlling the delivery of the agent. The housing has sufficient flexibility such that when it is engaged with the patch to form the patch assembly and the patch is adhered to a target site on the patient's skin, the assembly has sufficient flexibility to deform with movement of the patient's skin to remain sufficiently adhered to the skin over an extended period of time to transdermally deliver a desired dose of the agent.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: June 30, 2020
    Assignee: InCube Labs, LLC
    Inventor: Mir A. Imran
  • Patent number: 10660510
    Abstract: Disclosed herein a liposuction cannula that comprises a tube with a front end at which there is provided at least one suction opening, and with a back end intended to be connected to a source of vacuum; in the tube there being defined at least one longitudinal flow conduit for the aspirated material; and an imaging apparatus capable of supplying first signals or data allowing the generation of a visual representation of the environment in close proximity to the front end of the tube of the cannula down to a first depth or distance, and second signals or data allowing the generation of a visual representation of the environment around the front end of the tube of the cannula down to a second depth or distance, greater than the said first depth or distance.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: May 26, 2020
    Inventor: Corrado Campisi
  • Patent number: 10631726
    Abstract: In a corneal measurement system, an optical element focuses an excitation light to an area of corneal tissue at a selected depth. In response, a fluorescing agent applied to the cornea generates a fluorescence emission. An aperture of a pinhole structure selectively transmits the fluorescence emission from the area of corneal tissue at the selected depth. A detector captures the selected fluorescence emission transmitted by the aperture and communicates information relating to a measurement of the selected fluorescence emission captured by the detector. A controller receives the information from the detector and determines a measurement of the fluorescing agent in the area of corneal tissue at the selected depth. The system may include a scan mechanism that causes the optical element to scan the cornea at a plurality of depths, and the controller may determine a measurement of the fluorescing agent in the cornea as a function of depth.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: April 28, 2020
    Assignee: Avedro, Inc.
    Inventors: Desmond Christopher Adler, Jun Zhang, Mikhail Z. Smirnov, Marc D. Friedman, David Usher, Grace Elizabeth Lytle, David C. Iannetta
  • Patent number: 10632195
    Abstract: A pharmaceutical device for electric-field assisted administration of Tapentadol and/or of a physiologically acceptable salt thereof, the device comprising at least one pair of electrodes consisting of an active electrode and a counter electrode (1a and 2a and/or 1b and 2b), optionally at least one additional electrode as an auxiliary electrode, at least one drug reservoir (3) containing at least a portion of the Tapentadol and/or a physiologically acceptable salt thereof, and means (4) for applying the device to skin (5).
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: April 28, 2020
    Assignee: GRUENENTHAL GMBH
    Inventors: Ingo Friedrich, Martin Mikyna, Sandra Gedat, Richard Guy
  • Patent number: 10617774
    Abstract: A light emitting cover which inactivates microorganisms for covering a high touch surface is disclosed. The light emitting cover includes a body having an interior configured to cover at least a portion of the high touch surface and an exterior surface configured to be disinfected. At least an exterior portion of the body is transparent or translucent. A light emitter operably is coupled to the body for emitting a light through the exterior surface. The light exiting the exterior surface has at least a portion thereof having a wavelength in a range of 380 to 420 nanometers to disinfect the exterior surface.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: April 14, 2020
    Assignee: Vital Vio, Inc.
    Inventors: Cori Winslow, Colleen Costello, Nicholas Jones, Robert Barron, William Grambo, Jorel Lalicki
  • Patent number: 10582994
    Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer The implant may include a tissue graft. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, thereby avoiding need for rehydrating steps that are required for dehydrated or cryopreserved implants. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: March 10, 2020
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
  • Patent number: 10576220
    Abstract: A medication delivering injector having electrical sensor pads in communication with a microcontroller such that contact with the patient's skin and the angle at which the injector is held against the skin and the steadiness with which the injector is being held can be ascertained. A haptic vibrator and audio speaker produce a vibration which is variable in pitch in such a manner that biofeedback is provided to the injector user as to the pressure, angle and steadiness with which they are holding the injector. Multiplexed onto the electrical sensor pads, is a TENS (Transcutaneous Electrical Nerve Stimulation) generator which is operational (at the user's choice) just before and during the injection to interrupt or quench the pain of tissue perforation often accompanied with needle injections.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: March 3, 2020
    Assignee: IntelliPen Inc
    Inventor: Charles K. Armes
  • Patent number: 10569101
    Abstract: A portable irradiation device is disclosed including: a hollow squeezing part operable to squeeze air therein out; a sucker having a first end opening portion and a second end opening portion, the first end opening portion being hermetically connected with the squeezing part, the second end opening portion being attachable to a human body by means of a difference in air pressure between inside and outside the sucker; and a blue light irradiation unit located in a space surrounded by the squeezing part, the sucker, or the squeezing part and the sucker. Also disclosed is a method for manufacturing a portable irradiation device.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: February 25, 2020
    Assignees: BOE TECHNOLOGY GROUP CO., LTD., BOE OPTICAL SCIENCE AND TECHNOLOGY CO., LTD.
    Inventor: Jiefei Wu
  • Patent number: 10561838
    Abstract: An iontophoresis system includes a preloaded reservoir containing one or more doses of a therapeutic agent. As a result, the therapeutic agent does not have to be loaded into the reservoir prior to use. In such a system, the preloaded reservoir is generally disposable. Various components of the iontophoresis system can be combined with the reservoir in a disposable cartridge that is selectively connectable to other, reusable components of the iontophoresis system. In addition, the entire iontophoresis system can be formed from one or more disposable, one-time-use modules.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: February 18, 2020
    Assignee: P Tech, LLC
    Inventors: Peter M. Bonutti, Justin E. Beyers, Tonya M. Bierman
  • Patent number: 10556106
    Abstract: Embodiments of the invention provide methods for the transdermal delivery of therapeutic agents for the treatment of addictive cravings e.g., nicotine compounds for the treatment of nicotine cravings from tobacco use. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: February 11, 2020
    Assignee: INCUBE LABS, LLC
    Inventors: Mir A. Imran, Talat Imran, Mir Hashim
  • Patent number: 10555754
    Abstract: Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: February 11, 2020
    Assignee: Cytrellis Biosystems, Inc.
    Inventors: Alec Ginggen, Douglas Levinson, David Stone
  • Patent number: 10549021
    Abstract: A pump having at least a fluid pump chamber (11) and a first driver chamber (12) separated from the fluid pump chamber (11) by an elastic wall (13, 13-1, 13-2) is described with the first driver chamber (12) expanding after a chemical reaction between fuel and oxidant and driving through deformation of the elastic wall fluid out of the fluid pump chamber (11), with the main parts of the pump being made of an elastic material to be used for example as a body implant.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: February 4, 2020
    Assignee: ETH Zurich
    Inventors: Wendelin Jan Stark, Christoph Schumacher, Roland Fuhrer, Michael Loepfe
  • Patent number: 10538848
    Abstract: The invention concerns a method for controlling at least one gas bubble produced in a localised manner in a medium (3?) allowing the movement of said at least one gas bubble, characterised in that it comprises a step consisting of generating at least one ultrasound burst towards said at least one gas bubble, said at least one burst being emitted for a burst duration at least partially covering a duration during which said gas is effectively being produced.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: January 21, 2020
    Assignees: Centre National de la Recherche Scientifique, Ecole Centrale de Marseille, Universite d'Aix Marseille
    Inventors: Younes Achaoui, Serge Mensah, Zoubida Hammadi, Roger Claude Marcel Morin, Eric Debieu, Cédric Alain François Marie Payan
  • Patent number: 10529930
    Abstract: Compounds of formula (1) that have functional substituents in a specific spatial arrangement, and electronic devices that include a compound of formula (1), and to the preparation of compounds of formula (1).
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: January 7, 2020
    Assignee: Merck Patent GmbH
    Inventors: Amir Hossain Parham, Irina Martynova, Anja Jatsch, Thomas Eberle, Jonas Valentin Kroeber, Christof Pflumm
  • Patent number: 10525255
    Abstract: In an embodiment, an electrical stimulation system can include one or more of an electrode assembly including one or more electrodes and an electronics subsystem. In some variations, each of the one or more electrodes can include a hydrophilic layer and a conductive layer. In some variations, the electronics subsystem can include one or more of a control module, power module, and a stimulus generator. In some variations, the electrical stimulation can further include one or more of an electrical attachment system, mechanical attachment system, head apparel assembly, flexible housing, and/or any other suitable component. The electrical stimulation system functions to apply electrical stimulation but can additionally or alternatively function to measure/and or record one or more biosignals from a user.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: January 7, 2020
    Assignee: Halo Neuro, Inc.
    Inventors: Brett Wingeier, Ian Shain, Colin Davis, Victoria Hammett, Mardis Bagley, Phnam Bagley
  • Patent number: 10525156
    Abstract: A gastro-intestinal (GI) scope device for use in the disinfection of a patient's colon including a gastro-intestinal (GI) scope having an insertion tube and a universal cord, an ultraviolet (UV) light assembly, and a UV light sleeve assembly, wherein the UV light assembly includes a power source, a UV light box operatively connected to the power source, and a UV light source operatively connected to the UV light box, wherein the UV light source is located within an interior of the insertion tube and the UV light sleeve assembly is located on an end of the insertion tube in order to disinfect a patient's colon.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: January 7, 2020
    Inventor: Phong Duy Bui
  • Patent number: 10519226
    Abstract: The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a VEGF neutralizing prodrug, which comprises a VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: December 31, 2019
    Assignee: Ascendis Pharma Opthalmology Division A/S
    Inventors: Harald Rau, Thomas Knappe, Burkhardt Laufer, Romy Reimann, Samuel Weisbrod, Kennett Sprogøe, Nicola Bisek, Sebastian Stark, Tobias Voigt
  • Patent number: 10498234
    Abstract: A voltage regulator has a switching circuit and a control circuit. The switching circuit provides an output voltage and an output current. The control circuit provides a switching control signal to the switching circuit to adjust the output voltage, such that the output voltage decreases with a first slope as the output current increases when the output current is less than a first current level, the output voltage decreases with a second slope as the output current increases when the output current is larger than the first current level and is less than a second current level, and the output voltage decreases with a third slope as the output current increases when the output current is larger than the second current level.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 3, 2019
    Assignee: Monolithic Power Systems, Inc.
    Inventors: Chao Liu, Daocheng Huang, Lijie Jiang, Wangmiao Hu, Jinghai Zhou
  • Patent number: 10492716
    Abstract: Various collection devices, systems and methods relating to the use of devices with open microfluidic channels disposed within a housing defining a lumen. These devices make use of microneedles passed through apertures to induce fluid flow into microfluidic channel networks for collection and analysis. The device can be actuated via button when placed on the skin of a patient to collect a fluid sample, such as a blood draw.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: December 3, 2019
    Assignee: Tasso, Inc.
    Inventors: Erwin Berthier, Ben Casavant, Ben Moga
  • Patent number: 10485967
    Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: November 26, 2019
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Mohammad Sameti, Ronald Hackbarth, Klaus Schumann, Christoph Schmitz
  • Patent number: 10478333
    Abstract: The invention concerns an ocular iontophoresis device for delivering at least one active substance to an eyeball, comprising: a wall defining a tubular-shaped body delimitating laterally a reservoir configured for receiving the active substance(s), the wall comprising a circular distal end configured for being positioned on an ocular surface of the eyeball and surrounding the cornea and a part of the sclera of the eyeball, a first electrode configured to be positioned in front of the sclera, said first electrode being configured for delivering a first current density to the active substance(s) of the reservoir, the first electrode defining an annular-shaped first surface that is arranged in a peripheral part of the reservoir, a second electrode configured to be positioned in front of the cornea, said second electrode being configured for delivering a second current density to the active substance(s) of the reservoir, the second electrode defining a disk-shaped second surface that is arranged in a central part
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: November 19, 2019
    Assignee: OPIA TECHNOLOGIES
    Inventor: Pierre Roy
  • Patent number: 10478610
    Abstract: The present invention is directed to a method and apparatus for an electrotherapeutic system including a first and second electrode. Each electrode includes a respective resistance wherein during operation of the electrotherapeutic system, an electrochemical reaction involving one or both of the electrodes varies the respective resistance of at least one of the electrodes.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: November 19, 2019
    Assignee: Encore Medical Asset Corporation
    Inventors: Jon E. Beck, Robert F. Hause, Jr.
  • Patent number: 10471249
    Abstract: A device for increasing a concentration of at least one analyte in an advective flow of biofluid includes an agent for enhancing a paracellular permeability of an epithelial tissue; and an iontophoresis electrode and a counter electrode, which are adapted to increase the concentration of said analyte in the advective flow of the biofluid. A method of sensing an analyte in a biofluid includes increasing a paracellular permeability of an epithelial tissue layer; and inducing electro-osmotic flow by reverse iontophoresis to increase a concentration of said analyte in an advective flow of the biofluid, wherein said advective flow is driven by at least one of saliva generation, sweat generation, or reverse iontophoresis.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 12, 2019
    Assignee: University of Cincinnati
    Inventors: Jason Charles Heikenfeld, Andrew Jajack, Michael Charles Brothers
  • Patent number: 10456567
    Abstract: A dermal device for skincare therapy is provided including: a fluid circuit including a fluid pump and a reservoir; and a dermal interface configured to contact a user's skin, the dermal interface including at least one electrode and part of the fluid circuit having at least one perforation, wherein the at least one electrode is configured to deliver an energy pulse to the contacted skin, wherein the reservoir is configured to hold at least one topical, wherein the fluid pump is configured to pump the at least one topical through the fluid circuit and extrude the at least one topical through the dermal interface.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: October 29, 2019
    Assignee: L'OREAL
    Inventor: John Streeter
  • Patent number: 10449297
    Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: October 22, 2019
    Assignee: Palo Alto Research Center Incorporated
    Inventors: David K. Biegelsen, Eugene M. Chow, Armin R. Volkel, Ashish Pattekar, Mandana Veiseh
  • Patent number: 10413671
    Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: September 17, 2019
    Assignee: Portal Instruments, Inc.
    Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
  • Patent number: 10384051
    Abstract: The present application relates to a device for the electroporation of bacterial cells in or on a surface of the Stratum corneum layer of a person's skin. It comprises electrodes positionable in the vicinity of said surface; a generator to supply a voltage to the electrodes to generate an electrical field having a strength in the order of 25 to 35 KV/cm at said surface of the Stratum corneum layer to inactivate bacterial cells in or on said surface. The electrodes are configured so that the strength of the electrical field reduces as a function of the depth of penetration into the skin from 25 to 35 KV/cm at said surface to 3 KV/cm or less at a depth of penetration that does not exceed 15 microns.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: August 20, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Eduard Gerard Marie Pelssers, Mark Thomas Johnson, Johannes Hendrikus Maria Spruit, David Halter, Roland Cornelis Martinus Vulders, Robby Petrus Cornelis Van Dreumel, Marco Baragona
  • Patent number: 10383957
    Abstract: The potential use of a PMMA encapsulated near-infrared fluorescent dye includes endoscopic tattooing of intestinal neoplasms, location visualization of non-palpable breast lesions, and, but not limited to, location/visualization of soft tissue lesions in difficult anatomic regions. Commercially available fluorescent imaging systems, both open and laparoscopic, would be used in conjunction to fluoresce these marked tissues, augmenting the surgeon's ability to intraoperatively locate the correct lesion to resect.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: August 20, 2019
    Inventor: Anthony H. de Haas
  • Patent number: 10383687
    Abstract: The present invention relates to a system (100) for combined ablation and ultrasound imaging of associated tissue (40), which is particularly useful for use in an ablation process. The system comprises an interventional device (20) with an ultrasound transducer and an ablation unit. During an ablation process, the interventional device (20) can be applied for both ablation and imaging of the tissue (40) subject to the ablation. A controlling unit (CTRL) is further comprised within the system, and arranged to calculate a predictor value based on one or more signals from the ultrasound transducer, where the predictor value relates to a risk of impending tissue damage due to a rapid release of bubble energy. According to a specific embodiment, a primary signal is sent if the predictor value exceeds a threshold value, so that proper measures can be taken.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: August 20, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Godefridus Antonius Harks, Szabolcs Deladi, Jan Frederik Suijver, Maya Ella Barley, Edwin Gerardus Johannus Maria Bongers
  • Patent number: 10376600
    Abstract: A method for early stage pathology detection, location, imaging, evaluation, and treatment of cells and/or extracellular vesicles in the circulation.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: August 13, 2019
    Inventor: Gholam A. Peyman
  • Patent number: 10376366
    Abstract: A medical implant system for implantation in a patient to treat erectile dysfunction includes a first fluid path, an inflatable penile prosthesis cylinder, an electric pump, and implant controller, and an implantable power supply. The inflatable penile prosthesis cylinder is in fluid communication with the first fluid path and is configured for implantation in a corpus cavernosum of a patient. The electric pump is in fluid communication with the first fluid path. The implant controller is electrically coupled to the pump and is configured to activate the pump to drive a flow of fluid through the first fluid path and into the cylinder. The implantable power supply provides electrical power to the pump.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: August 13, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Shay Moshe Vaingast, Charles C. Kuyava
  • Patent number: 10350189
    Abstract: Described herein is a method for treating a central nervous system disorder, said method comprising steps of first transnasally administering to or immediately adjacent the sphenopalatine ganglion a first pharmaceutical agent that effectively enhances permeability of the blood-brain barrier; and thereafter administering a second pharmaceutical agent with known efficacious value for action upon central nervous system tissue. The central nervous system disorder may be related directly to the brain or to other central nervous system tissues and cells.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: July 16, 2019
    Inventor: Tian Xia
  • Patent number: 10342973
    Abstract: A therapeutic electron transfer device including a half-cell and an ionically conductive path for ion transfer between an organism and the half-cell. The half-cell includes an electrically conductive electrode, an active material in contact with the electrode, and an electrically conductive path for electron transfer between the organism and the electrode. The active material includes an oxidizing agent or a reducing agent, such that electron transfer occurs spontaneously from or to the organism, respectively. A kit includes therapeutic electron transfer device and instructions for use. Two therapeutic electron transfer devices may be used simultaneously or alternately to provide electrons to an organism, withdraw electrons from an organism, or both.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: July 9, 2019
    Assignee: KURAL CORP.
    Inventors: Jason Avent, Shahryar Michael Kiamanesh
  • Patent number: 10335422
    Abstract: Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the promotion of skin regeneration. Also provided herein are methods for promoting skin regeneration and wound healing.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: July 2, 2019
    Assignee: International Stem Cell Corporation
    Inventors: Rodolfo Gonzalez, Maxim Poustovoitov, Russell A. Kern