Infrared, Visible Light, Ultraviolet, X-ray Or Electrical Energy Applied To Body (e.g., Iontophoresis, Etc.) Patents (Class 604/20)
  • Patent number: 11116530
    Abstract: Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and/or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: September 14, 2021
    Assignee: CALYXO, INC.
    Inventor: Matthew Yurek
  • Patent number: 11116659
    Abstract: Disclosed are devices and methods for body temperature management using a heat transfer catheter carrying a heat transfer fluid to heat or cool a desired, focused portion of a patient's body. In accordance with certain aspects of the invention, the heat transfer catheter may include hollow nodes that have greater rigidity than the remainder of the catheter to aid in placement of the heat transfer catheter within and navigation of the desired portion of the patient's body. Methods of using such heat transfer catheter to effect temperature management of the patient's body are also disclosed.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: September 14, 2021
    Assignee: University of Maryland, Baltimore
    Inventors: Bingren Hu, Chunli Liu
  • Patent number: 11110222
    Abstract: A fluid interface device for delivering fluid to and/or withdrawing fluid from a patient, the device comprises a peripheral base element (2) and a fluid transmission element (4) sealingly connected to the base element and forming a central portion of the device. The fluid transmission element comprises a front platelet (6) with a primary face (8) and a secondary face (10) opposed thereto, the primary face being in contact with a patient's body fluid region (12) when the device is implanted in the patient, the fluid transmission element further comprising a counterplate (14) sealingly stacked against the secondary face of the front platelet and forming a buffer volume (16) therebetween. The front platelet comprises at least one array of microchannels (18) defining a fluid passage between the buffer volume and the primary face, the microchannels having an opening of 0.2 to 10???. The counterplate has at least one fluid port (20; 20a, 20b) for fluid delivery to and/or fluid withdrawal from the buffer volume.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 7, 2021
    Inventor: Carlo Andretta
  • Patent number: 11107216
    Abstract: A system and method for microscopic image processing. The method includes cleaning leaks shown in images to create cleaned images, each of the images having a neuron signal intensity, wherein the images include at least one neuron channel image and at least one oligodendrocyte channel image, wherein cleaning the images further includes applying a filtering function to each of the images and adjusting the neuron signal intensity of each of the images based on an output of the filtering function; detecting oligodendrocytes in the cleaned images, wherein each detected oligodendrocyte is a region of the images including an object for which the neuron signal intensity is within a range of neuron signal intensities; and identifying high-intensity sub-regions within each detected oligodendrocyte, wherein each high-intensity sub-region includes at least one high-intensity object, wherein each high-intensity object is an object for which the neuron signal intensity is above a threshold.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: August 31, 2021
    Assignee: The Joan and Irwin Jacobs Technion-Cornell Institute
    Inventor: Shahar Barbash
  • Patent number: 11103705
    Abstract: Devices and methods to deliver microcurrent stimulation therapy to the human body, when connected to a micro-stimulation current-generating apparatus. The method of applying microcurrent stimulation therapy to key points around the eye for treatment of problems such as macular degeneration, retinitis pigmentosa, glaucoma, optic neuritis and other eye-related or nerve-related conditions, as well as other diseases, such as Bell's Palsy, requiring localized stimulation to the eyes and/or on other body parts.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: August 31, 2021
    Assignee: i-Lumen Scientific, Inc.
    Inventors: Blair P. Mowery, Marshall T. Masko, John B. Jarding, Gary A. Tapp
  • Patent number: 11090475
    Abstract: A medical treatment system including a treatment chamber, a source of an aqueous mist containing a medication, a source of an oxygen-enriched gas, and a control system adapted to alternately surround a human body part with a mist containing a medication and the oxygen enriched gas, which can be used to treat various skin disorders including infected lesions, bacterial infections such as acne (i.e. Proplanibacterium acnes), fungal infections such as Athelete's foot (i.e. fungal genus Trichophyton), conditions associated with hair loss including alopecia as well as ulcerations and frostbite resulting form poor circulation. A method of treating skin disorders is also disclosed, that includes providing a mist containing a medication and enriched oxygen gas to the site being treated its well as providing oxygen to the patient during treatment.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: August 17, 2021
    Assignee: Vaporox, Inc.
    Inventor: Adrian Pelkus
  • Patent number: 11094571
    Abstract: An apparatus for executing a direct transfer of a semiconductor device die from a first substrate to a second substrate. The apparatus includes a first substrate conveyance mechanism movable in two axes. A micro-adjustment mechanism is coupled with the first substrate conveyance mechanism and is configured to hold the first substrate and to make positional adjustments on a scale smaller than positional adjustments caused by the first substrate conveyance mechanism. The micro-adjustment mechanism includes a micro-adjustment actuator having a distal end and a first substrate holder frame that is movable via contact with the distal end of the micro-adjustment actuator. A second frame is configured to secure the second substrate such that a transfer surface is disposed facing the semiconductor device die disposed on a surface of the first substrate. A transfer mechanism is configured to press the semiconductor device die into contact with the transfer surface of the substrate.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 17, 2021
    Assignee: Rohinni, LLC
    Inventors: Andrew Huska, Cody Peterson, Justin Wendt, Luke Dupin
  • Patent number: 11076997
    Abstract: A wound dressing that incorporates a number of sensors can be utilized in order to monitor characteristics of a wound as it heals or to identify one or more risk factors or conditions that may precipitate a wound. The wound dressing can include at least one sensor, such as an impedance sensor, that may be restricted from sensing in a direction away from the wound when the wound dressing is positioned in contact with the wound.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 3, 2021
    Assignee: Smith & Nephew PLC
    Inventors: Allan Kenneth Frazer Grugeon Hunt, Felix Clarence Quintanar
  • Patent number: 11077251
    Abstract: A device for delivery of particles into biological tissue includes at least one conduit and a propellant source fluidically coupled to the conduit and configured to deliver a propellant into the conduit. A particle source is configured to release elongated particles into the conduit, the elongated particles having a width, w, a length, l>w. The propellant source and the conduit are configured to propel the elongated particles in a collimated particle stream toward the biological tissue. An alignment mechanism is configured to align a longitudinal axis of the elongated particles to be substantially parallel to a direction of the particle stream in an alignment region of the conduit. The aligned elongated particles are ejected from the conduit and impact the biological tissue.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: August 3, 2021
    Assignee: Palo Alto Research Center Incorporated
    Inventors: David K. Biegelsen, Eugene M. Chow, Armin R. Volkel, Ashish Pattekar, Mandana Veiseh
  • Patent number: 11065441
    Abstract: An implantable medical device assembly includes a mounting structure, an electrode protruding from a surface of the structure, between opposing sides thereof, and tissue-penetrating fixation tines, each extending from a corresponding shoulder of the structure surface, adjacent to the opposing sides. In a relaxed condition, each tine extends away from the surface and then bends toward a proximal end of the structure and back toward the surface. In an extended condition, each tine bends toward a distal end of the structure and extends along the corresponding shoulder. A holding member of a delivery tool has opposing sidewalls defining a cavity, wherein each sidewall includes a rail-like edge that fits in sliding engagement with a corresponding shoulder, to deform a corresponding tine into the extended condition, when an operator passes the assembly into the cavity. Applying a push force, to move the assembly back out form the cavity, releases the tines.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: July 20, 2021
    Assignee: Medtronic, Inc.
    Inventors: Matthew D. Bonner, Raymond W. Usher, Teresa A. Whitman, Jean M. Carver, Kathryn Hilpisch
  • Patent number: 11058874
    Abstract: Provided is an iontophoresis device. An iontophoresis device according to an embodiment of the present invention includes a power supply unit configured to supply power; two electrodes configured to supply current to a user's skin when brought into contact with the skin, thereby allowing an ionic drug or an active ingredient applied to the user's skin to permeate the skin by an electrical repulsive force; and a control unit configured to adjust an output value of a voltage or a current applied to the electrodes according to the user's skin condition, thereby allowing the user to feel a uniform intensity of electrical stimulation.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: July 13, 2021
    Assignee: Amosense Co., Ltd.
    Inventors: Jin Young You, Dong Kun Lee, Sang Dong Jeong, Dong Woo Kim, Yeun Ho Bang
  • Patent number: 11058866
    Abstract: A variety of graphically responsive defibrillation electrode pads are described that can selectively display different images during use. The graphically responsive pads include a base electrode pad structure, at least two graphics, and one or more controllable layers that have multiple states. In some embodiments, the controllable layer incorporates an electrochromic material. In a first (opaque) state, the controllable layer hides the first graphic such that only the second graphic is visible to a user on the back side of the defibrillation electrode pad. When the controllable layer transitions to a second (transparent) state, the first graphic is made visible to thereby cause a composite image that combines the first and second graphics to be visible on the back side of the pad. In some embodiments, the electrochromic layer defaults to the opaque state when no power is applied to the electrochromic layer.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: July 13, 2021
    Assignee: Avive Solutions, Inc.
    Inventor: Gordon Moseley P. Andrews
  • Patent number: 11058596
    Abstract: A device for providing phototherapy. The device has lights that emit irradiance to provide phototherapy. The lights are positionable to emit the irradiance towards a patient. An enclosure is connected to a base and supports the lights. A control module is operatively connected to the lights and controls the irradiance emitted from the lights. A non-transitory memory module is operatively connected to the control module and stores a control program. A plurality of sensors is operatively connected to the control module and are configured to sense a current position of the lights. The control program is configured to receive inputs that include at least the current position of the lights and to provide outputs to the control module based at least in part on the inputs. The control module controls the irradiance emitted from the plurality of lights based at least in part on the outputs.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: July 13, 2021
    Assignee: General Electric Company
    Inventors: Anand Kumar, Jikku Philip, Sirosh Sivasankaran
  • Patent number: 11052240
    Abstract: A medical device for administering a medicament is disclosed that includes a reservoir for storing the medicament, a current driver electrically coupled to an electrode, and an oscillation driver electrically coupled to a vibrational element. The electrode forms multiple channels in fluid communication with the reservoir. A method of administering a medicament is also provided.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: July 6, 2021
    Assignee: HG MEDICAL TECHNOLOGIES LLC
    Inventor: Julian Henley
  • Patent number: 11045553
    Abstract: The present disclosure provides method of making a nanoparticle complex wherein the nanoparticle complex comprises a ligand and a metal cation. The disclosure also provides nanoparticle complexes, methods of treating a disease in a patient utilizing the nanoparticle complexes, methods of identifying a disease in a patient utilizing the nanoparticle complexes, and kits involving the nanoparticle complexes.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: June 29, 2021
    Assignee: AUBURN UNIVERSITY
    Inventors: Feng Li, Wu Chen, Pengyu Chen
  • Patent number: 11045648
    Abstract: Biological cell destruction is achieved through a combination of injection of a substance and application of an electrical field. The substance, such as a cationic polymer, is selected for its electrical characteristics which can add to the transmembrane electric field of a cell when the electrical field is applied. In some examples, electrical field application is performed to encourage spatial concentration of the injected substance favorable to increased transmembrane field strength. The biological cell or cells are destroyed primarily through irreversible electroporation.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: June 29, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Matthew Ryan Dewitt, Bruce R. Forsyth, Hong Cao
  • Patent number: 11040190
    Abstract: Multilayer electrodes, electrode systems, and stimulation systems are disclosed. An electrode may include a conductive layer with a unitary tail, a connector disposed on a distal end of the tail, and a nonconductive top layer disposed along a top portion of the conductive layer. An electrode may include a magnetic lead connector socket, or a receptacle formed by a depression in the conductive layer configured to receive a male connector. An electrode system may include a plurality of conductive zones and a plurality of connectors. A stimulation system may include an electronics layer in electrical contact with a conductive layer via a puncture connection, and may provide an iontophoretic treatment followed by a TENS treatment. Other electrodes, systems and methods are also disclosed.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: June 22, 2021
    Assignee: DJO, LLC
    Inventors: Thomas Jerome Bachinski, Michael Moore, Jay Dave, Joseph Winn
  • Patent number: 11040182
    Abstract: Described are microneedle devices comprising an electron beam crosslinked or photocrosslinked polymer material, and methods of making and using them, such as for drug delivery or sampling biological fluids.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: June 22, 2021
    Assignee: NOVEN PHARMACEUTICALS, INC.
    Inventors: Masayuki Suzuki, Cormac H. Lyons
  • Patent number: 11033723
    Abstract: Transdermal therapeutic systems are described which have at least one electronic component, as well as methods for producing this type of transdermal therapeutic systems.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: June 15, 2021
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Wolfgang Laux, Beatrix Platt, Nico Reum
  • Patent number: 11033317
    Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: June 15, 2021
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Bryan Loomas, Michael D. Laufer, David P. Thompson, Christopher J. Danek, Thomas M. Keast
  • Patent number: 11027017
    Abstract: The invention concerns a method of generating an immune response in a subject, comprising administering to the subject an antigenic molecule, a photosensitizing agent, a checkpoint inhibitor, and irradiating said subject with light of a wavelength effective to activate the photosensitizing agent to generate an immune response. Preferably the method is a method of vaccination. The invention also provides related methods, compositions, cells, uses, products and kits.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: June 8, 2021
    Assignee: PCI Biotech AS
    Inventor: Anders Høgset
  • Patent number: 11027071
    Abstract: An jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: June 8, 2021
    Assignee: Inovio Pharmaceuticals, Inc.
    Inventors: Jay McCoy, Kate Broderick, Stephen Kemmerrer
  • Patent number: 11007364
    Abstract: A stimulator and a method using electrical stimulation of a spinal cord, for providing positive regulation of multiple symptoms other than pain is disclosed. An example method includes positioning a first pair of implantable electrodes to a dura matter in an epidural space proximate to a subject's spinal cord at predetermined locations, positioning a second pair of implantable electrodes to the dura matter in the epidural space proximate to the subject's spinal cord at predetermined locations, and transmitting signals of first and second frequencies through the first and second pairs of implantable electrodes respectively, so that the signals of the first and second frequencies interfere with each other to produce at least one beat signal proximate to the subject's spinal cord. The at least one beat signal has a frequency within a range of more than 250 Hz to about 15,000 Hz.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: May 18, 2021
    Assignee: Meagan Medical, Inc.
    Inventor: William J. Carroll
  • Patent number: 10994122
    Abstract: An electrical stimulation device is provided. According to one embodiment of the present invention, the electrical stimulation device for applying an electrical stimulation to the skin of a user comprises: a patch layer, which is a single patch layer and makes contact with the skin of the user when the electrical stimulation device is worn by or attached to the user; and a plurality of patch segments formed to be spaced apart from each other on the patch layer and transmitting current to the patch layer.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: May 4, 2021
    Assignee: Y-BRAIN INC.
    Inventor: Kiwon Lee
  • Patent number: 10994112
    Abstract: A drug delivery device (100) includes a base (102) having a first region (104) with a drug delivery assembly (106) associated therewith. The drug delivery device also includes an antenna (112) disposed in the first region to radiate an electromagnetic field, the base defining a plane (114) and the antenna disposed in the plane of the base, and an electromagnetic field generator (116) selectively coupled to the antenna.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: May 4, 2021
    Assignee: AMGEN INC.
    Inventors: Stephanie Toy, Mark Ka Lai Lee, Donald Busby, Melissa D. Norton, Jeffrey Chen
  • Patent number: 10988757
    Abstract: Provided is a magnetic nanostructure for detecting and isolating cell-free DNA (cfDNA) that including a cationic polymer and a magnetic-nanoparticle-containing conductive polymer. The magnetic nanostructure for detecting and isolating cfDNA according to the subject matter can significantly improve detection and extraction efficiencies of DNA present in a urine, CSF, blood plasma, or blood sample, and exhibits an enhanced sensitivity. Therefore, it is expected that the magnetic nanostructure for detecting and isolating cfDNA according to the subject matter will be used for extracting DNA for use in a genetic mutation diagnosis service as well as for an early cancer diagnosis and cancer treatment.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: April 27, 2021
    Assignee: GENOPSY CO., LTD.
    Inventors: Youngnam Cho, Eun Sook Lee, HyungJae Lee, Ji-Youn Han, Sang-Hyun Hwang
  • Patent number: 10987062
    Abstract: Methods and systems of catheterization include a flexible catheter adapted for insertion into a heart of a living subject. The catheter has a lumen for passing an electrically conductive fluid therethrough, which is propelled by a peristaltic pump. A fluid reservoir connected to the lumen supplies the fluid to the catheter. Electrocardiogram circuitry is connectable to the subject for monitoring electrical activity in the heart. An electrically conductive cable diverts induced charges in the fluid from the catheter electrodes, for example by shorting to a rotating element in the peristaltic pump.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: April 27, 2021
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: John Hardy Ashton, George Kamin, Jose G. Ramos
  • Patent number: 10980992
    Abstract: Disclosed herein are microneedle devices, kits comprising the microneedle devices, and methods of using the microneedle devices. Specifically, disclosed is a device for transport of a material across a biological barrier of a subject comprising: a plurality of microneedles each having a base end and a tip, with at least one pathway disposed at or between the base end and the tip; a substrate to which the base ends of the microneedles are attached or integrated; and at least one reservoir which is in connection with the base ends of the microneedles array, wherein the reservoir comprises an agent delivery system, wherein the agent delivery system comprises an agent to be transported across the biological barrier, or a means for producing an agent to be transported across the biological barrier, and a means for detecting a physiological signal from the recipient.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 20, 2021
    Assignee: North Carolina State University
    Inventors: Zhen Gu, Yanqi Ye
  • Patent number: 10974065
    Abstract: A system and method for modulating optogenetic vagus neurons in a noninvasive and transcutaneous manner is disclosed. The system and method comprises a two-dimensional array of organic light emitting diodes (OLEDs), a voltage-generating unit, a control unit, and a feedback loop. The array is placed on a subject's outer ear. Because the array is flexible, it can be closely placed on the skin of the outer ear. The array can deliver optical therapy and monitor heart rate variability (HRV) of the subject simultaneously, and the pixels of the array can be individually addressed. The voltage-generating unit generates pulsed voltage to the OLEDs. The control unit is connected to the array and controls the array and therapeutic patterns. The feedback loop uses the HRV to identify the therapeutic patterns.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 13, 2021
    Assignee: ARIZONA BOARD OF REGENTS OF BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Joseph T. Smith, Michael Goryll, Dixie Kullman, Jitendran Muthuswamy, Jennifer Blain Christen
  • Patent number: 10974045
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: April 13, 2021
    Assignees: University of South Florida, Old Dominion University
    Inventors: Mark Jeffery Jaroszeski, Richard Heller
  • Patent number: 10966621
    Abstract: Embodiments include microelectrodes including a flexible shank and a bioabsorbable material surrounding the flexible shank. The flexible shank can include a flexible substrate, a circuit, and a plurality of sensors. Embodiments also include a methods of forming flexible active electrode arrays including depositing a flexible polymer on a substrate. The methods also include forming a plurality of sensors on the flexible polymer and attaching a silicon-based chip to the flexible shank. The methods also include coating the flexible shank in a bioabsorbable material and cutting the shank and a portion of the bioabsorbable material from the substrate.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: April 6, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Shu-Jen Han
  • Patent number: 10969395
    Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: April 6, 2021
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: John A. Rogers, Jungil Choi, Johnathan T. Reeder
  • Patent number: 10953098
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: March 23, 2021
    Assignees: The Regents of the University of California, Alchemical Research Holdings, LLC
    Inventors: Jose Manuel Mejia Oneto, Ziyad F. Al-Rashid
  • Patent number: 10952608
    Abstract: A procedure is performed on at least one section of an ocular component. At least one first electro-magnetic radiation is provided to the section so as to interact with at least one acoustic wave in the ocular component. At least one second electro-magnetic radiation is produced based on the interaction. Multiple portions of the second electromagnetic radiation are received. Each portion was emitted from a different corresponding segment of the section. A visco-elastic modulus of the section is monitored based on the multiple portions during the procedure. Feedback is applied to the procedure based at least in part on the monitored visco-elastic modulus, including at least one of: (1) guiding a trajectory of an incision based on different respective monitored values of visco-elastic modulus for the segments, or (2) determining a number of incisions to be made based on different respective monitored values of visco-elastic modulus for the segments.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 23, 2021
    Assignee: The General Hospital Corporation
    Inventors: Jang Lawrence Hyun Yoo, Dominik Jean Michel Beck, Giuliano Scarcelli, Niaz Karim, Seok-Hyun Yun
  • Patent number: 10946193
    Abstract: A pulse generation system is disclosed. The pulse generation system includes a controller, an output terminal, and a plurality of pulse generator circuits. The controller is configured to cause a driving signal pulse to be transmitted to any selected one or more of the pulse generator circuits, and to cause the driving signal pulse to not be transmitted to any selected one or more other pulse generator circuits. Each of the pulse generator circuits is configured to generate an output voltage pulse at the output terminal in response to the driving signal pulse being transmitted thereto.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: March 16, 2021
    Assignee: PULSE BIOSCIENCES, INC.
    Inventors: Brian G. Athos, Shu Xiao, David J. Danitz, Mark P. Kreis, Darrin R. Uecker
  • Patent number: 10945878
    Abstract: A dual modality system includes a chassis having a receptacle and means to couple the chassis to a desired treatment area of a user's body; a durable energy subsystem coupled to the chassis, arranged and configured to deliver energy to the desired treatment area of a user's body; and a replaceable thermal subsystem arranged and configured for removable placement in the receptacle of the chassis, arranged and configured to deliver thermal energy.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 16, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Austin Deng, Laura Higgins, Alexandru Paunescu, Ryan Walsh
  • Patent number: 10932945
    Abstract: A dual modality system includes a flexible chassis including a durable energy subsystem and a replaceable thermal subsystem. The durable energy subsystem has a plurality of energy emitters disposed in an emission region of the chassis having a length and a width, wherein the emission region length and emission region width are both substantially greater than an emission region depth. The replaceable thermal subsystem has a thermal source affixed to flexible web having an adhesive surface and at least one structure arranged and configured to couple the thermal subsystem to a chassis comprising a durable energy subsystem in a configuration wherein the thermal source is substantially superposed over the emission region of the chassis.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 2, 2021
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Austin Deng, Laura Higgins, Alexandru Paunescu, Ryan Walsh
  • Patent number: 10931472
    Abstract: Embodiments of the invention provide a system for adapting a pool pump for wireless communication. In some embodiments, a system for adapting a pool pump with a serial communication port for communication with a user via a remote server, an internet connection, and internet enabled device is provided, the system comprising: a wireless gateway device connected to a router; and a wireless adapter connected to the serial communication port, comprising: a gateway node; a transceiver; and a processor programmed to: establish a wireless connection with the wireless gateway; receive a first message from the pool pump; cause the gateway node to modify the first message; cause the first modified message to be transmitted to the remote server via the wireless gateway; receive a second message from the remote server; modify the second message for output to the pool pump; and transmit the second modified message to the pool pump.
    Type: Grant
    Filed: January 15, 2019
    Date of Patent: February 23, 2021
    Assignee: PENTAIR WATER POOL AND SPA, INC.
    Inventors: Hassan Khalid, Micheal Pasche, Brian Broga, Robert Westphal, Brian Boothe
  • Patent number: 10918725
    Abstract: An ophthalmic composition is provided that includes rebamipide and a method for preparing the same. The ophthalmic composition of maintains its transparency for a long time even in a physiologically neutral to weakly basic pH range that does not injure the cornea and conjunctiva of a patient suffering from dry eye and has improved stability so as not to be re-dispersed.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 16, 2021
    Assignee: SAMJIN PHARMACEUTICAL CO., LTD.
    Inventors: Eui-Hwan Cho, Sung-Ju Choi, Sung-Woo Lee, Hee-Jong Shin, Min-Hyo Ki, Mee-Hwa Choi, Dong-Ha Lee
  • Patent number: 10905870
    Abstract: The present invention relates to electroporation (EP) devices that are able to generate an electroporation causing electrical field at the mucosal layer, and preferably in a tolerable manner. Further, it includes the generation of a protective immune response, cellular and/or humoral, using the oral EP device along with a genetic construct that encodes an immunogenic sequence.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: February 2, 2021
    Assignee: Inovio Pharmaceuticals, Inc.
    Inventors: Stephen V. Kemmerrer, Kate Broderick, Jay McCoy
  • Patent number: 10888847
    Abstract: The present disclosure relates to a UV- and visible-light photocatalytic titanium dioxide composite material. In particular, the disclosure relates to a 5 photocatalytic titanium oxide composite material for the decomposition of airborne pollutants.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: January 12, 2021
    Assignee: Envision SQ Inc.
    Inventors: Scott Shayko, Cheng Lu, Xin Qiu
  • Patent number: 10874123
    Abstract: A method and a system for producing a change in a medium. The method places in a vicinity of the medium an energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The energy modulation agent has a normal predominant emission of radiation in a first wavelength range outside of a second wavelength range (WR2) known to produce the change, but under exposure to the applied initiation energy produces the change. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 29, 2020
    Assignee: IMMUNOLIGHT, LLC
    Inventors: Frederic A. Bourke, Jr., Zakaryae Fathi, Harold Walder, Wayne F. Beyer, Jr.
  • Patent number: 10874856
    Abstract: A device treats a region of the body of a patient having a cutaneous ulcer, including: a hydrogel, hydrocolloid, hydrocellular or hydrofiber primary dressing, impregnated with treprostinil, that can be shaped to the contours of the region to be treated, a so-called “active” electrode in contact with the primary dressing, a so-called “passive” electrode at a distance from the active electrode, a DC generator, the terminals of which are connected to the electrodes, the cathode and the anode respectively forming the active electrode and the passive electrode for iontophoresis, so as to cause treprostinil to migrate by cathodal iontophoresis into the region to be treated.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: December 29, 2020
    Assignees: Centre Hospitalier Universitaire Grenoble, Hopital Nord, Universite Joseph Fourier—Grenoble 1
    Inventors: Jean-Luc Cracowski, Matthieu Roustit, Sophie Blaise
  • Patent number: 10866484
    Abstract: A cleansing lighting device includes a laser light source configured to emit light in the visible light spectrum or in the infrared light spectrum. The cleansing lighting device also includes a light frequency up-converter to convert longer wavelength light from the laser light source to shorter wavelength light. The converted light has a dominant wavelength in the portion of the ultraviolet range at or below 380 nm, suitable for the cleansing application. An example cleansing lighting device may also include an optical element, such as a beam shaping lens or a variable optical beam deflector, to distribute the resulting ultraviolet light from the up-converter for the cleansing application. Such a cleansing lighting device may be a standalone device, although the device or individual components for light-based cleansing may be incorporated in a luminaire, for example, together with an artificial light source adapted to general illumination.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: December 15, 2020
    Assignee: ABL IP HOLDING LLC
    Inventors: Guan-Bo Lin, David P. Ramer, Yan Rodriguez, Sean P. White
  • Patent number: 10842979
    Abstract: An intelligent bioelectric module for use with a drug delivery system has a case and a set of at least two electrodes in electrical communication with a detection surface of the case. The case is configured so that, in use, the detection surface comes into electrical communication with (i) a second surface of the delivery system when a first surface of the delivery system has been put into contact with a tissue surface of a human or animal subject or (ii) the tissue surface that is adjacent to a portion contacted by the first surface of the delivery system or (iii) both the second surface and the tissue surface.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: November 24, 2020
    Assignee: Bioelectric Devices, Inc.
    Inventors: Michael Motion, Michel M. Maharbiz, Russell Potts
  • Patent number: 10835311
    Abstract: An electroporation apparatus and the method of using same are provided. The apparatus allows for the ablation of an area of tissue of arbitrary volume. The apparatus includes a plurality of conductive electrodes attached to a base plate and electrically connected to a pulse generator to allow individual electrical actuation of the electrodes. In use, the electrodes are inserted into an area of tissue to be ablated, such that the electrodes are in a first position. Predetermined ones of the electrodes are then activated to ablate tissue surrounding the activated electrodes, while leaving other ones of the electrodes un-activated. The electrodes are then moved to a second position which is different than the first position, and predetermined ones of the electrodes are then activated to ablate tissue surrounding the activated electrodes, while leaving other ones of the electrodes un-activated.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: November 17, 2020
    Assignee: Northwestern University
    Inventors: Alan V. Sahakian, Yearnchee C. Wang
  • Patent number: 10835629
    Abstract: A device for generating singlet oxygen is provided. The device has elongated posts extending from a surface, the lateral sides of which have particles with a sensitizer that converts triplet oxygen to single oxygen upon exposure to light. An optical fiber conveys light to the sensitizer and a gas supply tube conveys oxygen to the sensitizer. The device is configured to keep the sensitizer from contacting external fluids, such as saliva.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: November 17, 2020
    Assignee: Research Foundation of the City University of New York
    Inventors: Alan M. Lyons, Alexander Greer, QianFeng Xu
  • Patent number: 10835743
    Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: November 17, 2020
    Assignee: Vomaris Innovations, Inc.
    Inventors: Michael Nagel, Mary Maijer, Wendell King, Jeffry Skiba
  • Patent number: 10821296
    Abstract: Systems and methods for treating neuropathic pain by using a photobiomodulation device in a handheld manner. A robotic arm is attached to a light emitting device and controlled, using a visual display, to automatically position the light emitting device over areas to be treated on the patient's body. The automated light delivery process allows a patient to treat large portions of her body in a handsfree manner.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: November 3, 2020
    Inventors: Nadia Ansari, Kamran Ansari
  • Patent number: 10814129
    Abstract: A method and system for delivering a molecule to a specific area of a tissue by controlling temperature and impedance is presented. The method is generally comprised of applying heat to a biological structure, such as cells or tissues, to heat the biological structure to a preset temperature after which at least one electroporation pulse is administered to the biological structure. Impedance is measured as a feedback control mechanism after each pulse and pulse parameters are adjusted accordingly until desired impedance is reached. The system generally comprises an electroporation system capable of generating at least one pulse, measuring impedance and measuring temperature.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: October 27, 2020
    Assignees: University of South Florida, Old Dominion University
    Inventors: Mark Jeffery Jaroszeski, Richard Heller