Infrared, Visible Light, Ultraviolet, X-ray Or Electrical Energy Applied To Body (e.g., Iontophoresis, Etc.) Patents (Class 604/20)
  • Patent number: 11452638
    Abstract: Ultra-short pulsed laser radiation is applied to a patient's eye to create a row of bubbles oriented perpendicular to the axis of vision. The row of bubbles leads to a region of the eye to be ablated. In a second step, a femtosecond laser beam guided through the row of bubbles converts it to a channel perpendicular to the axis of vision. In a third step, a femtosecond laser beam is guided through the channel to ablate a portion of the eye. Using a femtosecond laser with intensity in the range of 1011-1015 W/cm2 for the second and third steps facilitates multi-photon ablation that is practically devoid of eye tissue heating. Creating bubbles in the first step increases the speed of channel creation and channel diameter uniformity, thereby increasing the precision of the subsequent multi-photon ablation.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: September 27, 2022
    Inventor: Nicholas S. Siegele
  • Patent number: 11452798
    Abstract: A method of treating a lesion in a gastrointestinal tract and an injectate system are provided. The method includes injecting a crosslinkable gel into a first tissue layer, the crosslinkable gel increasing a volume of the first tissue layer. The method also includes providing a crosslinker and resecting a portion of a first tissue layer having the increased volume away from a second tissue layer creating an exposed region in a remaining portion of the first layer and leaving a portion of the gel covering at least a portion of the exposed region. The injectate system includes a crosslinkable gel and a crosslinker where the crosslinkable gel and the crosslinker form a crosslinked gel having a compressive modulus of about 10-500 kPa.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: September 27, 2022
    Assignee: Cook Medical Technologies LLC
    Inventors: John C. Sigmon, Jr., Shaun D. Gittard, Gregory J. Hardy, Christopher A. Carruthers, Darin G. Schaeffer
  • Patent number: 11446495
    Abstract: According to some aspects, a device is presented herein that is configured to be located underneath an eyelid and worn by a user for treating dry eye. The device includes a first surface configured to face a portion of a sclera of the eye, and a second surface configured to face an eyelid and to be completely covered by the eyelid. In some embodiments, the device further includes a plurality of stimulation electrodes proximal to the first surface, wherein the plurality of stimulation electrodes is configured to stimulate the sclera. The device further includes an energy storage element coupled to the plurality of stimulation electrodes. The energy storage element is configured to supply power to the plurality of stimulation electrodes. The device further includes a processor configured to control a supply of energy from the energy storage element to the plurality of stimulation electrodes to stimulate the sclera.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: September 20, 2022
    Assignee: TWENTY TWENTY THERAPEUTICS LLC
    Inventors: Dimitri Azar, Fred Shungneng Lee, Timothy Stowe
  • Patent number: 11446492
    Abstract: An electrical stimulation apparatus includes a generator of sequential electrical pulses having predetermined values of parameters that include pulse amplitude, and duration and frequency of the pulses, the generator having one or more separate stimulation channels that independently deliver the pulse sequences to body areas. An electrode for each channel transmits the stimulation pulses and is applied outside the patient's skin at a predetermined region and with a predetermined position relative to the position of another electrode associated to another channel. One or more electrodes are borne by a flexible support element, fastenable in a position related to body anatomy, and are distributed on an extension of the support element according to a predetermined design, together with the pulse generator connected to the one or more electrodes or with two or more pulse generators connected to different electrodes also supported by the support element.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: September 20, 2022
    Inventors: Franco Bertora, Michele Palermo
  • Patent number: 11439807
    Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: September 13, 2022
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Mohammad Sameti, Ronald Hackbarth, Klaus Schumann, Christoph Schmitz
  • Patent number: 11433231
    Abstract: Described is a low voltage, pulsed electrical stimulation device for controlling expression of sonic hedgehog (“Shh”), a useful protein, by tissues. Also described are methods of enhancing expression of sonic hedgehog in cells, particularly a method of stimulating the expression and/or release of Shh in a cell having a gene encoding Shh, wherein the method includes applying a bioelectric signal of less than 50 Hz (e.g., 5 Hz, 10 Hz, or 20 Hz) at a pulse width duration of, e.g., 1 ms, to the cell (e.g., directly, indirectly, or wirelessly), and wherein the amount of Shh expression enhanced by this bioelectric signal is greater than that seen with a prior art bioelectric muscle stimulation or bioelectric muscle contraction alone as may be determined by, e.g., by an analysis of the upregulation of mRNA level/GAPDH fold gene expression in the cell.
    Type: Grant
    Filed: April 13, 2020
    Date of Patent: September 6, 2022
    Assignee: LEONHARDT VENTURES LLC
    Inventor: Howard J. Leonhardt
  • Patent number: 11420049
    Abstract: Embodiments herein relate to a medical device for treating a cancerous tumor, including an electric field generating circuit configured to generate one or more electric fields at or near a site of the cancerous tumor and control circuitry in communication with the electric field generating circuit. The medical device includes one or more supply wires in electrical communication with the electric field generating circuit and one or more supply electrodes. The supply electrodes are configured to deliver an electric field at or near the site of the cancerous tumor. The medical device can include one or more sensing wires in electrical communication with the control circuitry and one or more sensing electrodes. The sensing electrodes can be configured to measure an impedance of the cancerous tumor at at least two different electric field strengths. Other embodiments are also included herein.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: August 23, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Brian L. Schmidt, Benjamin Keith Stein, Keith R. Maile, William J. Linder, Ron A. Balczewski, Sarah Melissa Gruba, Tucker James Nelson, Aleksandra Kharam
  • Patent number: 11413441
    Abstract: Embodiments of the present disclosure provide a preparation delivery assembly including: a first substrate, a second substrate, and at least two needles of different lengths, each of which is a hollow needle having a hollow structure; wherein two side walls are provided between the first substrate and the second substrate to define a first chamber for containing a preparation by the first substrate, the second substrate, and the two side walls; at least one first channel that is in communication with the first chamber is provided in the second substrate in a direction substantially perpendicular to the second substrate; and the needles are arranged on a surface of the second substrate distal to the first substrate, and each of the needles is in communication with the first chamber through the at least one first channel to deliver the preparation.
    Type: Grant
    Filed: March 26, 2020
    Date of Patent: August 16, 2022
    Assignees: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Yongchun Lu, Hui Li, Pan Li, Chunping Long
  • Patent number: 11395916
    Abstract: Tumor treating fields (TTFields) can be delivered to a subject's body at higher field strengths by switching off one or more electrode elements that are overheating without switching off other electrode elements that are not overheating. This may be accomplished using a plurality of temperature sensors, with each of the temperature sensors positioned to sense the temperature at a respective electrode element; and a plurality of electrically controlled switches, each of which is wired to switch the current to an individual electrode element on or off. A controller input signals from the temperature sensors to determine the temperature at each of the electrode elements, and controls the state of the control input of each of the electrically controlled switches to selectively switch off the current or adjusted the duty cycle at any electrode element that is overheating.
    Type: Grant
    Filed: November 18, 2019
    Date of Patent: July 26, 2022
    Assignee: Novocure GmbH
    Inventors: Yoram Wasserman, Michael Krinitsky, Sergey Kirilov, Michael Shtotland, Victor Kaikov
  • Patent number: 11389369
    Abstract: A neuromodulation such as ultrasound therapy having a cuff and transducer to removably position on a penis of a patient in order to treat premature ejaculation. The transducer stimulates a dorsal nerve of the penis in order to stimulate or inhibit the nerve pathway between the penis and the brain in order to delay ejaculation until the user or their partner desires to have an ejaculation occur.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: July 19, 2022
    Inventors: Jeffrey Bennett, William Rissmann
  • Patent number: 11389628
    Abstract: A balloon catheter including a catheter shaft and an inflatable balloon secured to a distal end region of the catheter shaft. The inflatable balloon has a generally conical shape in a fully inflated configuration having a proximal conical portion that tapers away from the central longitudinal axis in a distal direction from a proximal waist of the balloon and a distal conical portion that tapers toward the central longitudinal axis in a distal direction toward a distal waist of the balloon, with a radially outermost extent of the balloon located between the proximal conical portion and the distal conical portion. The proximal conical portion, the distal conical portion and/or the radially outermost extent of the balloon has an elliptical cross-section taken in a plane perpendicular to the central longitudinal axis of the catheter shaft.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: July 19, 2022
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventor: Steven M. Spencer
  • Patent number: 11393570
    Abstract: Methods and systems are provided for tracking and guiding a patient's clinically directed medication usage. Medicaments are placed in secure passive packaging that must be unlocked to enable dispensing of a dose or a set of doses. This packaging is designed to be difficult to open manually, and instead is designed to dispense only when used in combination with an unlocking device. The unlocking device is a separate device containing electronics, mechatronics or both, to unlock and dispense from the packaging and to track and guide usage. Together, the secure container and the unlocking device track medication usage, deter an excessive rate of patient usage, and deter unauthorized access to medication.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: July 19, 2022
    Assignee: MedicaSafe, Inc.
    Inventors: Matthew J. Ervin, Aziz O. Nawrozie, Jason P. Wright, Malcolm V. Dell
  • Patent number: 11389642
    Abstract: The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 19, 2022
    Assignees: Cardiac Pacemakers, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Samuel J. Asirvatham, Suraj Kapa, Sarah M. Gruba, Douglas D. Pagoria, James P. Rohl, Chance M. Witt, Ammar M. Killu, Niyada Naksuk
  • Patent number: 11382631
    Abstract: An example assembly for use with a vacuum system and an esophageal positioning device esophageal positioning device includes an introducer, in which the esophageal positioning device includes a first segment and a second segment. The second segment is pivotally connected to the first segment. A gap portion of an outer tube of the introducer is defined along a longitudinal axis between a tube tip of the introducer and the distal end of the second segment of the esophageal positioning device when the esophageal positioning device is disposed within the introducer. The gap portion defines one or more radial vacuum holes.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: July 12, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Emile Daoud, William Fuller
  • Patent number: 11376423
    Abstract: Presented herein are techniques that enable electroporation of the cells of a recipient of a tissue-stimulating prostheses while the tissue-stimulating prosthesis is implanted in the recipient. Tissue-stimulating prostheses in accordance with embodiments presented herein are configured such that the stimulation electronics (e.g., current sources and integrated circuit) of the prosthesis are not exposed to the high voltages used in electroporation.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: July 5, 2022
    Assignee: Cochlear Limited
    Inventors: Torsten Lehmann, Paul Michael Carter, John Michael Heasman
  • Patent number: 11369776
    Abstract: A balloon catheter that includes an elongated main body extending in an axial direction and a balloon connected to the distal portion of the elongated main body. The balloon includes an interior and is inflatable and deflatable. The balloon catheter also includes a plurality of elongate bodies extending radially away from the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug. The elongate bodies each possess an independent longitudinal axis. Each of the elongate bodies includes a base portion at the proximal end of the elongate body. A plurality of elongate body proximal portions extend radially inwardly from the base portion of each of the elongate bodies toward the interior of the balloon. The elongate body proximal portions are continuous extensions of the crystal of the water-insoluble drug.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: June 28, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Katsumi Morimoto, Yasuo Kurosaki, Katsunori Ebata
  • Patent number: 11357971
    Abstract: A device for transport of ions and/or charged molecules between a source and a target electrolyte, comprising: a first electrode provided at or in said source electrolyte, and a second electrode provided at or in said target electrolyte; and wherein said first and second electrodes provides an electrical control of an ion flow, and further comprising means for limiting an electronic current between said source and said target electrodes, such that at least after a voltage is applied a potential difference between said source and target electrodes is maintained, which effects ion transport from said source to said target electrode; wherein the device further comprises an ion- and/or permselective polyelectrolyte for transport ions and/or charged molecules via electrophoresis and functions as an ion-selective membrane; and wherein said polyelectrolyte comprises a cross-linked hyperbranched polymer.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 14, 2022
    Assignee: OBOE IPR AB
    Inventors: Roger Gabrielsson, Mats Sandberg, Magnus Berggren, Daniel Simon, David J. Poxson, Tobias Freddie Abrahamsson
  • Patent number: 11358861
    Abstract: A method for encapsulating a sensing and/or actuator device, comprises the steps of providing a sensing and/or actuator device having a demarcation structure thereon. The sensing and/or actuator device comprises at least a substrate and a sensing and/or actuator element on the substrate. The demarcation structure contacts the substrate and defines an enclosed area of the substrate. The enclosed area comprises at least the sensing and/or actuator element. The method also comprises providing an encapsulation material outside the enclosed area, so the sensing and/or actuator element is left uncovered by the encapsulation material. The demarcation structure further comprises a capping structure overlaying the sensing and/or actuator element.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: June 14, 2022
    Assignee: INDIGO DIABETES NV
    Inventors: Juan Sebastian Ordonez Orellana, Pieter Espeel
  • Patent number: 11357607
    Abstract: A dental irrigation device for heating a solution and mixing solutes within the solution. The present invention utilizes an oscillator and inductive coil to heat and/or mix the solution. A pump then delivers the heated and mixed pressurized solution from a basin ultimately into a dispenser.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: June 14, 2022
    Inventor: Mark E. Goodson
  • Patent number: 11357574
    Abstract: The invention relates to a surgical instrument with an instrument handle, an instrument shank connected to the instrument handle, an instrument tip with a work point, which instrument tip is connected to the instrument shank, and a first locator arranged on the instrument handle or the instrument shank. During a use of the surgical instrument, the instrument shank can be deflected, e.g. on account of transverse forces, at least between the first locator and the work point. A second locator is arranged at a distance from the first locator and, by comparison with the latter, closer to the work point, wherein the second locator is designed to detect five degrees of freedom.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: June 14, 2022
    Assignee: Intersect ENT International GmbH
    Inventors: Timo Krüger, Dirk Mucha
  • Patent number: 11351347
    Abstract: This invention relates to a device and method for the vacuum-assisted delivery of drugs through an intact surface membrane of an organ.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 7, 2022
    Assignee: Vacu-Site Medical, Inc.
    Inventors: David Myung, Edward E. Manche, Donald J. Eaton, Anthony J. Abbate
  • Patent number: 11338135
    Abstract: Embodiments herein relate to medical device systems including electric field shaping elements for use in treating cancerous tumors within a bodily tissue. In an embodiment, a medical device system for treating a cancerous tumor is described. The medical device system can include one or more electric field generating electrodes and an electric field shaping element configured to be implanted along with the one or more electric field generating electrodes. The electric field shaping element can be made from a material that alters the spatial area of tissue exposed to the electric field. Other embodiments are also included herein.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: May 24, 2022
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Brian L. Schmidt, Jacob M. Ludwig, Benjamin J. Haasl, Michael J. Kane
  • Patent number: 11331478
    Abstract: An iontophoresis system for positioning against skin of a subject is disclosed. The iontophoresis system can comprise at least one vessel having a solvent therein. An anode apparatus can couple to the at least one vessel. The anode apparatus can comprise a first reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a first electrode positioned above the first reservoir. A cathode apparatus can couple to the at least one vessel. The cathode apparatus can comprise a second reservoir configured to receive the solvent from the at least one vessel so that, when received into the first reservoir, the solvent makes contact with the skin of the subject, and a second electrode positioned above the second reservoir.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: May 17, 2022
    Assignee: United States Government as Represented by the Department of Veterans Affairs
    Inventors: Anton Sabiev, William Bauman, Mark Korsten
  • Patent number: 11324552
    Abstract: A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: May 10, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Jerome M. Felsenstein, James L. Hedrick, James J. Wynne, Donna S. Zupanski-Nielsen
  • Patent number: 11318307
    Abstract: A device for delivery of TENS current or electrostimulation has a first skin contact electrode mounted on a first non-conductive fingertip base and having at least one contact area for current-bearing contact with skin and a connection to a TENS current source and has a second skin contact electrode, mounted on a non-conductive fingertip base that is the same as the first non-conductive fingertip base or is a second non-conductive fingertip base and having at least one contact area for current-bearing contact with skin and a connection to TENS current source. A control and power unit that supplies TENS current to flow through skin contacting and positioned between the first and second electrodes, and enables selecting the level of the current or energy supplied.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: May 3, 2022
    Assignee: NSE Products, Inc.
    Inventors: Dale G. Kern, Richard R. Best, Toan Doan
  • Patent number: 11312999
    Abstract: A set of genes for the molecular classifying of medulloblastoma is disclosed, including the following 24 genes: EPHA7 gene, OTX2 gene, ROBO1 gene, TTR gene, LGR5 gene, IGF2BP3 gene, TBR1 gene, ZFPM2 gene, TRDC gene, TRAC gene, PEX5L gene, NKD1 gene, RALYL gene, GABRA5 gene, GAD1 gene, TNC gene, KCNA1 gene, EOMES gene, MAB21L2 gene, WIF1 gene, DKK2 gene, PDLIM3 gene, IMPG2 gene, and KHDRBS2 gene. In addition, the present invention also discloses the use of the genome in the preparation of a kit and a gene chip for the molecular classifying of medulloblastoma. After validation, the present invention can accurately differentiate medulloblastoma WNT subgroup, SHE subgroup, Group3 subgroup, and Group4 subgroup, and has important clinical significance for the precise treatment of patients due to the objective results, high accuracy, and short experimental period.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 26, 2022
    Assignee: HANGZHOU CANHELP GENOMICS TECHNOLOGY CO. LTD.
    Inventors: Qinghua Xu, Chengshu Chen, Yifeng Sun, Jinying Chen, Qifeng Wang, Kaibin Song
  • Patent number: 11311715
    Abstract: The disclosure provides a self-powered sheet which is configured to absorb a liquid content and to be applied on a human skin. The self-powered sheet includes a base layer and a plurality of electrically conductive inks. The base layer is configured to absorb the liquid content and adapted to be applied on the human skin. The base layer has a contact surface. The electrically conductive inks are disposed on the contact surface of the base layer. Each of the electrically conductive inks has a plurality of first electrodes and a plurality of second electrodes. When each of the first electrodes and each of the second electrodes are soaked in the liquid content, an electrical potential difference between one of the plurality of first electrodes and one of the plurality of second electrodes generates a current in the human skin.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: April 26, 2022
    Assignee: CYMMETRIK ENTERPRISE CO., LTD.
    Inventors: Wen-An Lin, Che-Ling Chang
  • Patent number: 11311630
    Abstract: Embodiments of the present disclosure provide for magnetic particle conjugates, methods of making the magnetic particle conjugates, methods of using magnetic particle conjugates, micelles (also referred to as a “magnetic composite nanocarrier” (MCNC)), methods of making micelles, methods of using micelles, and the like.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: April 26, 2022
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Carlos Rinaldi, Sun Hao, Brent S. Sumerlin
  • Patent number: 11311233
    Abstract: A sensing and treatment device includes an array of metal nanorod electrodes formed on a substrate, the array including first electrodes for sensing, and second electrodes for electrical pulsation. A data processing system is configured to monitor a parameter using the first electrodes and to activate the electrical pulsation in the second electrodes in accordance with a reading of the parameter.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: April 26, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Hariklia Deligianni, Bruce B. Doris, Steven J. Holmes, Emily R. Kinser, Qinghuang Lin, Roy R. Yu
  • Patent number: 11305116
    Abstract: An electrical stimulation apparatus is provided. The electrical stimulation apparatus includes an electrode module receiving current for applying electrical stimulation to a skin of a user from a current providing part, a plurality of monitoring electrodes positioned spaced apart from each other on the electrode module, the current flows from the electrode module to the plurality of monitoring electrodes, and a current monitoring part monitoring the current flowing to each of the plurality of monitoring electrodes.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: April 19, 2022
    Assignee: Y-BRAIN INC.
    Inventors: Ki Won Lee, Jong Min Jang, Byung Gik Kim
  • Patent number: 11298263
    Abstract: A method of mitigating the development of myopia, includes measuring elasticity of collagen of an eye; identifying an eye for which the elasticity measured is above a preselected threshold; selectively applying a collagen cross-linking reagent proximate collagen of a sclera of a posterior pole portion of the eye for which the elasticity measured is above the preselected threshold; and irradiating at least the posterior pole portion of the eye with radiation of an appropriate wavelength to initiate covalent bonding and cross-linking of the collagen for which the elasticity measured is above the preselected threshold.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: April 12, 2022
    Inventor: Jack T. Holladay
  • Patent number: 11291827
    Abstract: An electroporation device having a battery pack including a plurality of battery cells and at least one lead in electrical communication with a circuit board. The battery pack including a safety switch and a controller for selectively placing the battery cells in electrical communication with the one lead. Where the controller is in operable communication with the safety switch such that when the controller detects one or more operating conditions the controller instructs the safety switch to electrically isolate the lead from the battery cells. The battery pack also includes a manual switch, and where activation of the switch causes the controller to instruct the safety switch to electrically isolate the lead from the battery cells.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: April 5, 2022
    Assignee: Inovio Pharmaceuticals. Inc.
    Inventors: Beat Stadelmann, Stephen Kemmerrer
  • Patent number: 11285335
    Abstract: A wavelength specific photo-modulation treatment device and method are disclosed which provide specific wavelength colors from a group of four different electromagnet colors arranged in a repeating scalable matrix array. The device includes a control system connected to the array for driving the devices in two different modes and three different color combinations.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: March 29, 2022
    Assignee: Biohacked, Inc.
    Inventors: David Asprey, Timothy K. Brodesser, Haiping Zeng
  • Patent number: 11273295
    Abstract: An implantable device for delivering a therapeutic agent to treat an ear of a patient includes a body having a distal end region and a proximal end region. The body defines, at least in part, a reservoir configured to contain the therapeutic agent. The device includes a shaft attached to the distal end region of the body and a lumen extending through the shaft having at least one inlet at a proximal end region in fluid communication with the reservoir and at least one outlet at a distal end region. Upon implantation of the body in a region of the ear, a length of the shaft is sufficient to extend from the body to at least the round window membrane of the ear. The device is configured to deliver the therapeutic agent to the ear from the reservoir via passive diffusion. Related devices and methods are described.
    Type: Grant
    Filed: April 18, 2019
    Date of Patent: March 15, 2022
    Assignee: SPIRAL THERAPEUTICS, INC.
    Inventors: Kevin W. Sacherman, Signe Erickson, Hugo Peris, Eugene de Juan, Jr.
  • Patent number: 11266832
    Abstract: An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The active molecule delivery system includes a first electrode, a plurality of microcells, and a porous conductive layer. The microcells are filled with a medium including active molecules.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: March 8, 2022
    Assignee: E INK CALIFORNIA, LLC
    Inventor: Lei Liu
  • Patent number: 11259869
    Abstract: Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: March 1, 2022
    Assignee: Farapulse, Inc.
    Inventor: Steven R. Mickelsen
  • Patent number: 11260128
    Abstract: The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two treatment modalities to synergistically treat primary and secondary tumor cells in a subject. The first element of the method comprises administering a therapeutically effective amount of a plasmonics-active metal nanoparticle to a subject comprising a primary cancer and a distant metastatic site, wherein the nanoparticle concentrates at the primary cancer. The method further comprises exposing the subject to photon radiation at the site of the primary cancer. The second element of the disclosed method comprises administering a therapeutically effective amount of an immune checkpoint modulator to the subject. The synergistic combination provides a rapid, safe, and effective treatment of local and distant lesions, better than each modality alone.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: March 1, 2022
    Assignee: Duke University
    Inventors: Tuan Vo-Dinh, Brant A. Inman, Paolo Maccarini, Greg Palmer, Yang Liu, Douglas Weitzel
  • Patent number: 11246646
    Abstract: A surgical instrument includes a hand piece having a fixed branch and a displaceable branch for actuating a first tool and/or second tool, a guide device in which a force transmission device is arranged to be displaceable longitudinally and/or rotationally, the force transmission device coupled, on the proximal side, to the fixed branch and/or displaceable branch and coupled, on the distal side, to the first tool and/or second tool, and a connection device on which the guide device can be coupled to the hand piece in an insertable and detachable manner by a coupling simultaneously providing a holding force for holding the guide device in the connection device, a bipolar electrical contact on the distal side of the hand piece for parts of the instrument requiring energy, and degrees of freedom for longitudinal and/or rotational movement of the guide device and/or force transmission device.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: February 15, 2022
    Assignee: AESCULAP AG
    Inventor: Tina Schwarz
  • Patent number: 11246977
    Abstract: A fluid delivery system (1) includes a reservoir (7) for storing a fluid, a pumping chamber (8) and an actuator (20). The pumping chamber (8) has a volume, an inlet valve (48) providing selective fluid communication between the pumping chamber volume and the reservoir, an outlet valve (49), and a membrane (47) the displacement of which changes the pumping chamber volume. The actuator (20) moves a drive member (21) in reciprocating motion. The actuator (20) is disposed in a housing (9) having an aperture (36) from which the drive member projects. The reservoir (7) and the pumping chamber (8) are arranged in a cartridge (3) removably attachable to the housing. When the cartridge (3) is attached to the housing (9) the drive member (20) is operatively coupled to the pumping chamber membrane (47). The fluid delivery system may be applied to an infusion system for the infusion of a liquid therapeutic product, such as insulin.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: February 15, 2022
    Assignee: ViCentra B.V.
    Inventors: Tim Oakes, Joseph Cefai
  • Patent number: 11241374
    Abstract: The present invention provides compositions, methods and kits for treating skin, which combine administration of glucosamine hydrochloride and red light having a peak wavelength of about 600 nm to about 750 nm, near infrared light having a peak wavelength of about 750 nm to about 1000 nm, or both.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: February 8, 2022
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Michelle Chen, Ali Fassih, Jennifer M. Li, Wen-Hwa Li, Liliam A. Moreira, Ramine Parsa, Michael D. Southall
  • Patent number: 11229779
    Abstract: A method for skin ligament injection incorporates the benefits of regenerative medicine to provide more natural and longer lasting results in the revitalization of a patient's face. The method includes a first phase in which through the use of aspiration tubes with reduced diameter, small aspiration holes and controlled aspiration pressure with aspiration in a superficial plane of the skin, a user collects tissue rich in stein cells with waste of fibrotic tissue. A second phase includes the sterile manipulation and washing of fat to collect only the tissue containing the stein cells arranged around vascular structures and growth factors collected inside organelles called exosomes. Lastly, a third and final phase includes injecting the obtained product into the skin of a patient.
    Type: Grant
    Filed: August 12, 2020
    Date of Patent: January 25, 2022
    Inventor: Enrico Guarino
  • Patent number: 11229610
    Abstract: The present disclosure relates to compositions methods of use and methods of manufacturing, hydrous hydrogel compositions useful as topical oral analgesics including cannabinoids and menthol where the menthol component can be a stabilized menthol composition comprising menthol and at least one menthol stabilizer compound including undecylenic acid methyl ester, undecylenic acid or a salt of undecylenic acid.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: January 25, 2022
    Inventors: Babak Ghalili, Emma Ghalili
  • Patent number: 11219930
    Abstract: The present invention provides a new filter cleaning method that has cleaning performance superior to that of ultrasonic cleaning. The method for cleaning a filter of the present invention includes the steps of: generating a shock wave; and bringing the shock wave into contact with a filter to which a filler adhered, wherein in the shock wave contacting step, a pressure applied to the filter by the shock wave is 0.07 MPa or more.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: January 11, 2022
    Assignees: Nagase Filter Co, Ltd., National University Corporation Kumamoto University
    Inventors: Toshiki Eguchi, Masayoshi Shimo, Hideki Hayashi, Kazuyuki Hokamoto, Shigeru Tanaka
  • Patent number: 11219598
    Abstract: An object of the present invention is to provide a sustained drug release system useful for treating eye diseases. There is provided a device for sustained release of an ophthalmic drug, comprising a drug enclosing part and an intraocular retention gas enclosing part adjacent to the drug enclosing part, the enclosing parts being provided in a hollow container having at least one opening part, wherein the drug enclosing part is isolated from the opening part by the intervention of the intraocular retention gas enclosing part.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 11, 2022
    Assignee: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY
    Inventor: Tsutomu Yasukawa
  • Patent number: 11207131
    Abstract: Devices, systems, and methods for reverse irrigation of an ablation or treatment site. In one embodiment, a reverse irrigation device comprises at least one ablation electrode and at least one reverse irrigation port, the at least one reverse irrigation port being located at at least one of immediately proximate the at least one ablation electrode and on the at least one ablation electrode, the at least one reverse irrigation port being configured to be in fluid communication with a fluid removal component. A medical system may include an ablation system and a reverse irrigation system that are configured to operate synchronously such that the reverse irrigation system is activated to remove fluid from the ablation site during a period of time during which the ablation system is activated to deliver ablation energy through the at least one ablation electrode to the ablation site.
    Type: Grant
    Filed: July 17, 2017
    Date of Patent: December 28, 2021
    Assignee: Medtronic, Inc.
    Inventors: Brian T. Howard, Steven V. Ramberg
  • Patent number: 11202696
    Abstract: A dental irrigation device for heating a solution and mixing solutes within the solution. The present invention utilizes an oscillator and inductive coil to heat and/or mix the solution. A pump then delivers the heated and mixed pressurized solution from a basin ultimately into a dispenser.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: December 21, 2021
    Inventor: Mark E Goodson
  • Patent number: 11185689
    Abstract: A skin treatment device includes a substrate and a plurality of discrete galvanic couples provided on the substrate, each discrete galvanic couple including a first conductive electrode that is an anode and a second conductive electrode that is a cathode, wherein the anode of each galvanic couple includes a first metal and the cathode of each discrete galvanic couple includes a second metal, different from the first metal, the first and second metal having a different standard potential.
    Type: Grant
    Filed: June 8, 2017
    Date of Patent: November 30, 2021
    Assignee: FEELIGREEN SA
    Inventors: Abdelwahhab Yakoub, Christophe Bianchi
  • Patent number: 11185626
    Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: November 30, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Carl Magnus Schoellhammer, Carlo Giovanni Traverso, Avraham Schroeder, Baris Polat, Daniel Blankschtein, Robert S. Langer, William Brugge
  • Patent number: 11185674
    Abstract: Medical devices comprising applicators that present a microneedle array and a separate electroporation array configured to simultaneously contact a tissue surface, a fluidic system connected to the microneedle array, and an electronic system connected to the electroporation array, for the coordinated delivery of a fluid biologic and electroporation energy to a tissue.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: November 30, 2021
    Assignee: Northwestern University
    Inventor: Rishi Arora
  • Patent number: 11160977
    Abstract: This application discloses an improved approach for delivering Tumor Treating Fields (TTFields) at a therapeutically effective strength to the infratentorial regions of the brain. A first set of electrode elements is positioned on top of the head and a second set of electrode elements is positioned on the back of the neck. Third and fourth sets of electrode elements are positioned on the lower back right and the lower back left portions of the scalp, respectively. Applying an AC voltage between the first and second sets of electrode elements generates a generally vertical field in the infratentorial regions of the brain; and applying an AC voltage between the third and fourth sets of electrode elements generates a generally horizontal field in those regions.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: November 2, 2021
    Assignee: Novocure GmbH
    Inventors: Ariel Naveh, Shay Levi, Zeev Bomzon, Eilon Kirson