Abstract: The assembly comprises: a stand for hanging a container of a main liquid, a spike, to be introduced into the container of main liquid, a multi-inlet connector with inlet tubings, to be connected to containers of additional liquids and to the container of main liquid through the spike, and an outlet tubing to be connected to a luer syringe to be introduced into a patient. The length of the spike inlet tubing of the connector has a length determined for, during use of the assembly with a container of main liquid, keeping the connector hung up on the stand through the spike and the container of main liquid. Thanks to the invention, the problem of the tubing traffic is solved.

Abstract: In some embodiments, a catheter device may include a catheter including a proximal end and a distal end. The catheter device may further include a connector coupled to the proximal end of the catheter. The connector may include a base having a recess configured to receive the distal end of the catheter and may include a hinged portion configured to couple to the base to clamp the catheter within the recess.

Abstract: Disclosed are various embodiments for an anti-reflux enema bag having a pulley restrictor that acts as a waterflow restrictor, where the enema bag is leakproof, easy-to-clean, and provides a steady flow of solution. An enema bag system includes an enema bag, a nozzle comprising a nozzle outlet, and an anti-reflux coupler positioned between the enema bag and the nozzle through which the solution passes from the enema bag to the nozzle outlet. The anti-reflux coupler comprises an inlet for receiving at least a portion of the solution from the enema bag; an outlet for expelling the solution into the nozzle; and a check valve configured to prevent reflux of the solution from the nozzle. The enema bag system further comprises a pulley restrictor configured to selectively control a speed at which the solution is introduced into the nozzle and expelled from the nozzle outlet.

Abstract: A proportional pinch valve for controlling the pressure of a fluid in a continuous flow system comprises an anvil for pinching a length of a tubing in the continuous flow system, and a drive mechanism including a displacement element for moving the anvil towards the tubing. The anvil is indirectly coupled to the displacement element via an elastic spring element. The elastic spring element provides a defined play (i.e. elasticity) for the anvil at least as long as the tubing is not fully pinched so that displacement of the anvil is force-controlled by the elastic spring element. A method of controlling the pressure of a fluid in a continuous flow system makes use of such a proportional pinch valve.

Abstract: A catheter assembly or other elongate tubular device for use in establishing vascular or other access within the body of a patient is disclosed. The catheter assembly is equipped with one or more sensors that enable monitoring of one or more physiological aspects of the patient or physical aspect of the catheter assembly itself when the catheter assembly is disposed within the patient. Such aspects include central venous pressure, body temperature, ECG heart signals, oxygen levels, ultrasound data, glucose, etc. The catheter assembly includes the ability to wirelessly transmit or otherwise forward data relating to the detected physiological parameters to another location, such as a patient electronic medical record, smartphone or other mobile device, nurse station, etc. Catheter assemblies configured to detect the frequency of catheter flushing, flushing quality, etc., are also disclosed.

Abstract: Systems and methods for automatic flow termination for fluid delivery, including a housing configured for coupling a fluid delivery tube to a needle configured for subcutaneous delivery of fluid within a tissue of a patient and a spring-loaded activation mechanism having a first orientation corresponding to a condition where the housing is disposed substantially adjacent to the tissue and the needle lodged within the tissue and a second orientation corresponding to a condition where the housing is disposed away from the tissue or the needle being dislodged from the tissue. A flow termination mechanism is coupled to the activation mechanism and having an open configuration allowing flow from the fluid delivery tube to the needle when the activation mechanism is in the first orientation and a closed configuration substantially terminating flow from the fluid delivery tube to the needle when the activation mechanism is in the second orientation.

Abstract: An artificial heart and lung apparatus includes a roller pump; a blood removal line; a first blood transfer line; a blood removal rate sensor; a control unit that performs the linked control of the roller pump in correspondence with a blood removal rate; and a blood transfer rate adjustment unit that instructs the roller pump to transfer a blood transfer rate. The blood transfer rate adjustment unit includes an operation amount input unit to which an operation amount from an arbitrary circumferential position can be input, and which outputs a pulse signal according to the input operation amount. A counter adds and subtracts pulse signals output from the operation amount input unit, and outputs a resultant as blood transfer rate adjustment data. The counter performs a counting operation with respect to the circumferential position of the operation amount input unit when blood transfer control transitions to the normal control.

Abstract: An exemplary pharmaceutical compounding system and device for mixing materials from at least two distinct material sources can include a transfer set and junction structure that has a junction body, a first inlet port located at a first portion of the junction body, a second inlet port located at a second portion of the junction body, and an outlet port located at a third portion of the junction body. A mixing chamber can be located between the outlet port and both the first inlet port and second inlet port, the mixing chamber configured to mix fluid received from both the first inlet port and second inlet port and to deliver the fluid to the outlet port. An attachment structure can be located on the junction body and configured to attach the junction structure to the housing of the compounding device.

Abstract: An intravenous delivery system may operate by gravity feed, and may have a liquid source containing a liquid, a drip unit that receives the liquid from the liquid source, and tubing that receives the liquid from the drip unit for delivery to a patient. A flow rate sensor may be used to measure a flow rate of liquid through the intravenous delivery system, and may generate a flow rate signal indicative of the flow rate. A controller may receive the signal, and may compare the flow rate with a desired flow rate. If the flow rate is more or less than the desired flow rate, the controller may transmit a control signal to a flow rate regulator. The flow rate regulator may receive the control signal and, in response, modify the flow rate to bring the flow rate closer to the desired flow rate.

Abstract: A blood bag system includes a clamp installed in a flexible first tube. The clamp includes: a base section having a protrusion section, an opening/closing section having a pressing protrusion section that presses a side surface of the first tube, and a bent section that connects the base section and opening/closing section. The base section is provided with a pair of cutout sections opened to a side surface where the first tube can be inserted by interposing the protrusion section. The clamp is configured such that a portion of the first tube where the clamp is installed is bent while the clamp is released.

Abstract: Systems and methods for automatic flow termination for fluid delivery, including a housing configured for coupling a fluid delivery tube to a needle configured for subcutaneous delivery of fluid within a tissue of a patient and a spring-loaded activation mechanism having a first orientation corresponding to a condition where the housing is disposed substantially adjacent to the tissue and the needle lodged within the tissue and a second orientation corresponding to a condition where the housing is disposed away from the tissue or the needle being dislodged from the tissue. A flow termination mechanism is coupled to the activation mechanism and having an open configuration allowing flow from the fluid delivery tube to the needle when the activation mechanism is in the first orientation and a closed configuration substantially terminating flow from the fluid delivery tube to the needle when the activation mechanism is in the second orientation.

Abstract: A method of cannulating vasculature includes inserting the vasculature through a first clamping surface of a cannula and rotating a second clamping surface of the cannula around the first clamping surface to move from an open position towards a closed position. Additionally, the method includes securing the vasculature between the first clamping surface and the second clamping surface.

Abstract: The present invention relates to a device for connecting at least one external functional device to an arrangement, wherein the device includes at least one first contact portion and at least one second contact portion for receiving the external functional device between the first contact portion and the second contact portion, and at least the first contact portion or the second contact portion is movable. It further relates to a method for connecting at least one external functional device to an arrangement by using the device of the present invention, as well as an arrangement which includes at least one device of the present invention.

Abstract: A cannula has a longitudinal base member having a first clamping end and a longitudinal arm member pivotally attached to the longitudinal base member and having a second clamping end, the cannula being in a closed position when the first and second clamping ends are brought together. A first clamp member is located at the first clamping end and has a first passage. A second clamp member is rotatably attached to the arm member at the second clamping end and has a second passage. The first and second passages form a combined passage when the clamp is in the closed position. The cannula may have a first locking member positioned on the arm member and a second locking member positioned on the base member. The first and second locking members interact with each other to lock the cannula in the closed position.

Abstract: A clamp for selectively compressing a portion of tubing, such as an extension leg of a PICC or other catheter, is disclosed. The clamp is able to be opened or closed with a thumb and finger of a single hand of a user and is slidably attached to the tubing so as to enable its placement as desired along the tube. In one embodiment, the tubing clamp comprises a body including first and second body portions hingedly connected to one another in a clamshell configuration, a latch for releasably latching the first and second body portions together, and at least two tube compression members. The tube compression members cooperate to compress and occlude a portion of tubing passing through the tubing clamp when the first and second body portions are latched to one another.

Abstract: The invention concerns a tube pump comprising a cradle (1) with a cavity (11) suitable for the accommodation of a tube clamp (2). It further concerns a tube clamp (2) for a flexible tube, the tube clamp being suitable for accommodation in a tube pump, the tube clamp having a mobile part and an immobile part (20) designed to penetrate at least partly into a housing (11) realized in the tube pump. The invention also concerns a perfusion set. Finally, the invention concerns a system comprising a tube pump and a tube clamp. In order to provide a system comprising a tube pump and a tube clamp with improved operation safety, the tube pump has a cavity (11) with at least one protrusion (14) and the tube clamp (2) has means (21) for snapping attachment of the tube clamp behind the protrusion (14).

Abstract: A medical tube clamp wherein first and second plate parts including, on opposing surfaces, compressive protrusions for closing a medical tube are provided with a pair of side walls on both sides projecting from one toward an other of the plate parts, and are also provided with a central guide protrusion projecting from the other toward the one of the plate parts. Both sides of a tip portion of the central guide protrusion make sloping guide surfaces projecting toward a center. When the plate parts are displaced relative to each other so as to become closer, lateral displacement of them is corrected by a slide of the pair of side walls and the sloping guide surfaces, and the central guide protrusion is inserted between the pair of side walls.

Abstract: A flow control clamp having a first member and a second member movable from a first open position to a second irreversibly closed position wherein flow through a tube associated with the clamp is irreversibly prevented and cannot be restored. Systems and methods using such clamps are also disclosed.

Abstract: An infusion pump is provided with a slide clamp mechanism having a clamp member for closing or opening an infusion tube and a valve mechanism for pressing the infusion tube to stop flow of a solution in the infusion tube and has a structure where an interlocking mechanism for interlocking the slide clamp mechanism with the valve mechanism only by manipulation of a handle is disposed. During a series of manipulations of the handle, the infusion tube is always closed by one or both of the slide clamp and valves 14A and 14B, so that free flow of a solution in the infusion tube 40 can be entirely prevented.

Abstract: A delivery tube is inhibited from unintended withdrawal from an infusion pump which has an internal occlusion clamp that clamps the delivery tube to prevent the free flow of fluid through the tube, by overlapping a blocking lip from a compression edge of the occlusion clamp with a restraint surface of an anvil against which the tubing is compressed and by overlapping a blocking projection from the restraint surface with the compression edge. Inhibition is also achieved by positioning an obstruction protrusion adjacent to the compression edge and the blocking lip to resist the application of exterior physical force to force the occlusion clamp from an occluding position to a non-occluding position.

Abstract: An improved safety occluder and method of use provides an occluder for an infusion set having a first, occluding position, a second, non-occluding position which returns to the first, occluding position when the occluder's plunger is released, and a third, non-occluding position which retains the plunger in a configuration which allows fluid flow through the infusion set. The occluder may also include a locking mechanism to prevent accidental movement of the plunger out of the first, occluding position.

Abstract: A system by which resource information relating to an insertable medical device, such as an intravascular catheter, can be identified by its source so as to be accessed by a practitioner, caregiver, or patient, is disclosed. In particular, a resource information key is included at a predetermined key location on or proximate to the medical device, wherein the key indicates the source of the resource information. In one example embodiment, therefore, an insertable medical device for establishing intravascular access to a patient, such as a peripherally inserted central catheter (“PICC”), is disclosed and comprises: an internal portion, and a portion external to the patient that includes a resource information key indicating a website where a user can acquire resource information relating to the medical device. In other embodiments indicia are provided as quick response (“QR”) codes, and as various markings to indicate compatibility of the medical device with ethanol.

Abstract: An embodiment of the present invention comprises an adapter configured to divide a single input tubular line into multiple tubular lines used in infusion therapies, which has a manifold at one end that comprises a single input port (e.g., female luer, male luer, barbed tubular pole, or straight tubular port) to which a fluidic source may be connected, multiple output ports (e.g., female tubing ports or barbed tubular poles) to which output infusion tubular lines may be connected, a flow disburser feature to ensure even distribution of fluidic flow within the adapter, recessed slots in the sides of the adapter to clamp the output infusion tubular lines without the need for external clamps, and identifying markings on the outside of the adapter to uniquely identify each of the output tubular lines. The adapter may also incorporate an embedded flow restrictor or filter, eliminating the need for external components and their associated connectors.

Abstract: An occluder, and methods for occlusion, that employs first and second opposed occluding members associated with each other, a tube contacting member connected to, or comprising at least a portion of, at least one of the first and second occluding members, and a force actuator constructed and positioned to apply a force to at least one of the first and second occluding members. Application of the force by the force actuator may cause the tube contacting member to move between a tube occluding and an open position. A release member may be configured and positioned to enable an operator to manually move the tube contacting member from the tube occluding position to the open position even with no force applied to the occluding member by the force actuator. In one embodiment, the force actuator may apply a force sufficient to bend both the first and second occluding members, so that upon application of the force by the force actuator (such as an air bladder), the first and second occluding members (e.g.

Abstract: A device and method to constrict or occlude the lumen of a flexible tube may include an occluder under the influence of an elastic force, such as a spring force, that can compress a portion of the wall of the flexible tube. The occluder can be under the influence of the elastic force, but prevented from occluding the tube by a stop. The stop can be connected to a tube gripping feature, so that a pulling force on the tube near the gripping feature can disengage the stop from the occluder, releasing the occluder to compress the tube. In some embodiments, the pulling force applied to the tube causes movement of the gripping feature by taking up slack in a portion of the tube held in the device. In other embodiments, the pulling force applied to the tube causes the tube to stretch elastically near the gripping feature, causing the gripping feature to move, and disengaging the stop from the occluder.

Abstract: Skin port connectors for use as part of a percutaneous gastrostomy tube assembly and methods for connecting such a device to such an assembly are disclosed.

Abstract: Embodiments described herein generally relate to an apparatus and methods for preventing the recontamination of a pathogen-reduced fluid by pathogens trapped in one or more ports of an inactivation fluid container. Through the use of a slidable clamp positioned in an area of the container immediately adjacent to a port to be isolated, the port may be sealed to prevent any liquid product from entering the port and associated tubing when liquid product is added to the container. The slidable clamp includes a slot, in which the distal end of the slot has a larger width than the proximal end of the slot. The width of the slot at the narrowest, most proximal portion allows for a fluid-tight seal to be created when the slidable clamp is slid into the closed position with respect to the port to be isolated.

Abstract: An anti-free-flow mechanism includes an occluder mechanism which is disposed along a segment of tubing and a mounting structure. The occluder mechanism is normally in a biased closed position, but may be moved into an open position by placement in the mounting structure. However, unless force is applied to keep the occluder mechanism in the mounting structure, the occluder will move relative to the mounting structure and return to the first, closed position.

Abstract: A hemodialysis catheter assembly with a flexible catheter lead that can control blood flow at a hemodialysis access site even under high blood pressures encountered at such sites. Flexible tubing extends through the hollow interior of a housing having opposite, open ends. The assembly includes components to alternately occlude or not occlude the lumen of the flexible tubing. In a first embodiment, spring clips press against the tubing, but insertion of a hollow sleeve into the lumen thereof retracts the clips and provides a flow path. In a second embodiment, a pinch bar can be manually moved into and out of engagement with the flexible tubing to occlude or open a flow path. In a third embodiment, the housing has a screw cap. A spring-loaded pinch bar presses against, and occludes the lumen of, the collapsible tubing when the screw cap is screwed into a threaded cutout in the housing, and provides a flow path through the tubing when the screw cap is removed.

Abstract: An infusion tracker comprising a base and a cover configured to be assembled onto the base. The infusion tracker further comprises a memory tag, attached to one of the base and the cover and configured to store data and operable to wirelessly release stored data in a format readable by a processor-controlled device or to activate an application software. The infusion tracker is further configured to enclose a portion of an infusion line between two ends of the portion, the portion being enclosed substantially between the base and the cover.

Abstract: A medical tubing clamp includes a first member, a second member, and a hinge connecting the first and second members to form a body. The second member has a first and second wall portion extending distally toward the first member, and a shelf extending between and connecting the first and second wall portions. The first and second wall portions and the shelf define a recess. The hinge allows the first and second members to move relative to one another to transition the clamp between an open mode and a closed mode. The first member is located within the recess and supported by the shelf when in the closed mode. The hinge has a first opening configured to receive the tubing. The clamp also has a tubing closure member that deforms the tubing to prevent fluid flow through the tubing when in the closed mode.

Abstract: A retainer comprises a first member and a second member. The first member can define at least a portion of a channel. The channel can have a longitudinal axis and be configured to receive at least a portion of a medical article. The second member can be moveable with respect to the first member, between locked and unlocked positions. The second member can contact the portion of the medical article received by the channel at least when in the locked position so as to inhibit longitudinal movement of the medical article relative to the retainer.

Abstract: A method and apparatus are disclosed for a stabilization device for maintaining a position of a medical device relative to a body surface of a patient. The stabilization device comprises a support portion that defines a groove for receiving the medical device. The groove is structured to allow for positioning of the medical device at a plurality of angles relative to the body surface of the patient. The groove has opposing wall portions for securing the medical device.

Abstract: The invention relates to an infusion tube clamp for being inserted in an infusion pump comprising a base member having an infusion pump receiving area, a first clamping leg, and a second clamping leg for squeezing an infusion tube, wherein the two clamping legs are swivel-connected to each other at a first infusion tube clamp end. The infusion tube clamp also includes a click device for safely positioning the two clamping legs in more than one position relative to each other.

Abstract: An anti-free-flow mechanism includes an occluder mechanism which is disposed along a segment of tubing and a mounting structure. The occluder mechanism is normally in a biased closed position, but may be moved into an open position by placement in the mounting structure. However, unless force is applied to keep the occluder mechanism in the mounting structure, the occluder will move relative to the mounting structure and return to the first, closed position.

Abstract: The present invention generally relates to occluders and, in particular, to occluders for use in medical infusion systems. In one aspect, the occluder contains one or more tubes through which fluid can flow, and the occluder can be automatically controlled to allow or at least partially prevent fluid flow. In some cases, the occluder may be constructed and arranged to fail (e.g., due to loss of power) in a “closed” position, i.e., a position that at least partially prevents fluid flow. In addition, in one embodiment, the occluder may be manually overridden, even when in a failed state, by a user. For instance, in the event of a power failure, a user may be able to manually override the occluder to remove tubing from the occluder. Such occluders may find use, for example, in medical devices such as hemodialysis machines, medical infusion pumps, plasmapheresis devices, and the like.

Abstract: Disclosed is a cannula including a first clamping portion, a second clamping portion and a force applying portion configured to apply at least two different clamping forces across the first clamping portion and the second clamping portion when the cannula is in a closed state. The first clamping portion includes a first gear, the second clamping portion includes a second gear, and the first gear and the second gear are in meshing engagement.

Abstract: The present invention relates to a linear flow regulating apparatus for intravenous infusion, and more particularly, to a flow regulating apparatus which is used in an infusion set for intravenous infusion to regulate the flow rate of a solution injected into a body. To eliminate the difficulties caused by the nonlinearity of conventional flow regulating apparatuses, which regulate flow rates by pressing a solution flow tube to adjust the flow passage area, the linear flow regulating apparatus has a control unit to be put in or taken out along the width of a flow channel unit through which the solution flows when the height and length of the flow channel unit are fixed, and is capable of linearly regulating the flow rate by varying the flow passage area of the flow channel unit by adjusting the width of a flow channel unit.

Abstract: A medical clamp having a semi-circular front engagement portion with reciprocal transverse grooves formed in the opposing clamp surface. The semi-circular engagement portion allows for easy alignment, safe operation and completely eliminates the possibility of misalignment and unintentional release.

Abstract: A bowel management system includes a waste collection catheter having at least two distinct sections. The first section is patient proximal when disposed in the patient's rectum and has durometer hardness in the range of about 50A to about 90A. The second catheter section is connected to the first section and has durometer hardness in the range of about 5A to about 49A. A selectively collapsible, substantially spherical retention balloon is attached coaxially and exterior of the first catheter section such that the proximal-most end of the retention balloon is coincident to the proximal-most end of the first section of the waste collection catheter, the substantially spherical retention balloon having an inflated size so as to be sufficiently large enough to retain the patient proximal end of the catheter in the patient's rectum without being so large as to trigger a defecatory response in the patient.

Abstract: Positive displacement fluid lock ports for use in combination with an indwelling catheter and a syringe during a flushing/locking procedure are provided. The fluid lock port includes a housing having a distal and a proximal end; a resilient conduit supported within the housing, wherein the conduit defines a lumen therethrough; and at least one biasing member supported in the housing and being operatively associatable with the resilient conduit. The at least one biasing member has a first condition restrained from deforming the resilient conduit and a second condition operatively engaged with the resilient conduit to at least partially occlude the lumen of the resilient conduit.

Abstract: A variable hemostasis valve is disclosed that may be used during medical procedures to prevent blood loss while permitting the percutaneous introduction, operation, and removal of medical instruments. A flexible tubular seal element is disclosed that is disposed within the variable hemostasis valve to provide a fluid-tight, adjustable seal. After insertion of a medical instrument into the valve through at least a portion of the flexible tubular seal element, a proximal portion of the valve housing may be rotated to cause the tension of the flexible tubular seal element to increase over the inserted medical instrument and engage the valve in a closed position. The proximal portion of the valve housing may then be rotated in an opposite direction to release the seal and return the tubular seal element to a relaxed lumen open position.

Abstract: The illustrative embodiments described herein are directed to apparatuses, systems, and methods for managing liquid flow associated with a tissue site that involves using reduced pressure to control fluid flow. In one instance, an apparatus includes a first valve and a second valve in fluid communication with a reduced-pressure source. The valves are movable between an open position and a closed position and are operable to change flow status (open to closed or vice versa) based on a presence of reduced pressure. At least one of the first valve or the second valve is in the closed position to obstruct a flow of a liquid while the other is in the open position. The apparatus also includes a reservoir fluidly coupled to the first valve and the second valve. Other systems, methods, and apparatuses are presented.

Abstract: A disposable infusion device comprises a base arranged to adhere to a patient's skin, a cannula arranged to extend from the base to beneath the patient's skin to deliver a liquid medicament to the patient, and a source arranged to provide the cannula with a liquid medicament. The source includes a compressible tube that pumps the liquid medicament to the cannula.

Abstract: Bypass elements for medical valves and methods of using the same are disclosed. Embodiments of the invention include an insert having a tip that is adapted to displace a valve element without penetrating it, and a lumen that fluidly communicates with a lumen of a valve housing distal to the valve element when the bypass element is engaged. Bypass elements are used, in certain embodiments, to facilitate fluid pressure and ECG signal measurements through implanted medical devices including catheters.

Abstract: Disclosed is an infusion flow regulator, in which a reference point is set within a manipulating range of a manipulation unit for regulating a flow rate in the infusion flow regulator, so that a manipulating point of the manipulation unit can be tuned with reference to the ratio of a flow rate measured at the reference point in relation to a prescribed injection flow rate, whereby the flow rate can be quickly and accurately tuned to the prescribed flow rate. The disclosure also includes an infusion flow regulating set including the infusion flow regulator, and an infusion flow regulating method using the same.

Abstract: A feeding tube extension may be used to extend the length of a feeding tube. The feeding tube extension may comprise an extension tube and a connector configured to be inserted into a feeding port of the feeding tube. So the flow of fluids is not unduly restricted, an inner diameter of the extension tube and a diameter of a connector lumen may be selected to be a predetermined size relative to the a diameter of a feeding tube lumen. A feeding syringe interface may facilitate use of a feeding syringe with the extension tube. Various mechanisms may be used to seal the extension tube when feeding is complete. A right-angle bolster and catheter securing device may be configured to secure the feeding tube so that it does not kink or move and cause irritation.

Abstract: A valve apparatus for a medical injection system includes a pinching member and at least one spring-loaded anvil. A tubing line of the injection system may be positioned between the pinching member and the anvil, such that when the pinching member is moved into a pinching position adjacent to the anvil, for example, by rotation of a shaft to which the member is coupled, the pinching member compresses the tubing line against the spring-loaded anvil. The pinching member is preferably rotatable about an auxiliary axis, which is eccentric, or offset from a central axis of the shaft. A spring member of the spring-loaded anvil is preferably pre-loaded. In certain applications, the pinching member, when moved into the pinching position, applies a pinching force of greater than approximately 45 pounds, for example, to prevent flow through the tubing line at an injection pressure of up to approximately 1200 psi.

Abstract: A system and method for automatically delivering an infusate to a patient is disclosed. The system includes an infusion set and an infusion device. A signaling component disposed on an infusion set component identifies an administration protocol for the infusion set. A detection device operatively connected to the infusion device detects the signaling component and identifies the administration protocol. The infusion device is then configured to operate according to the administration protocol.

Abstract: The present disclosure relates to clamps for controlling the flow of liquid through a fluid circuit. More particularly, the present disclosure relates to flow control clamps that can be substantially irreversibly secured in a closed position, thereby preventing reopening of the flow path of the tube and providing a sterile closure.